[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f2r8zkm2512e5p":5},{"data":4},[],{"data":6,"error":11},{"id":7,"documentId":8,"slug":9,"name":10,"medical_code":11,"short_description":12,"alternate_name":11,"disambiguating_description":11,"citations":13,"drugs":25,"specialties":26,"cover":11},836,"sg093cqsm8ycuq12t2vfvm7l","adrenergic-alpha1-agonists","Adrenergic alpha1-Agonists",null,"Alpha-1 adrenoceptors are G protein-coupled receptors for the catecholamines noradrenaline and adrenaline. They signal through the Gq\u002FG11 family, stimulating the phosphatidylinositol-calcium pathway so that calcium is released from intracellular stores and protein kinase C is activated - the sequence that makes vascular smooth muscle contract. Drugs in this class bind and activate an alpha-1 receptor, reproducing that catecholamine effect; a drug belongs here because it switches the receptor on rather than blocking it.",[14,20],{"source":15,"licence":16,"source_url":17,"harvested_by":18,"retrieved_at":19},"RxClass (NLM)","US public domain","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002Fclass\u002FbyId.json?classId=N0000009917","load-reference-corpus.cjs","2026-09-13",{"source":21,"licence":22,"source_url":23,"harvested_by":18,"retrieved_at":24},"UniProt Knowledgebase entry P35348 (Alpha-1A adrenergic receptor)","CC BY 4.0 (UniProt Consortium)","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FP35348.json","2026-09-16",[],[]]