[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f1m6e858ypscxi":5},{"data":4},[],{"data":6,"error":11},{"id":7,"documentId":8,"slug":9,"name":10,"medical_code":11,"short_description":12,"alternate_name":11,"disambiguating_description":11,"citations":13,"drugs":28,"specialties":29,"cover":11},838,"yabnuen64axqyyltnpyrjjiv","adrenergic-alpha1-antagonists","Adrenergic alpha1-Antagonists",null,"Alpha-1 adrenoceptors are G protein-coupled receptors for the catecholamines noradrenaline and adrenaline that signal through the Gq\u002FG11 family: activation stimulates the phosphatidylinositol-calcium second messenger pathway, releasing calcium from intracellular stores and activating protein kinase C, and the receptor acts as a vasopressor in resistance arteries, helping maintain normal arterial blood pressure. Drugs in this class occupy that receptor without activating it, so circulating and neuronally released catecholamines can no longer act through it, and its vasopressor contribution is lost. A drug belongs here because it blocks an alpha-1 receptor; the alpha-1 and alpha-2 antagonist classes are not exclusive, and MED-RT files mirtazapine under both.",[14,20,24],{"claims":15,"source":16,"licence":17,"source_url":18,"retrieved_at":19},"Gq\u002FG11 coupling, phosphatidylinositol-calcium pathway, calcium release from intracellular stores, protein kinase C activation, binding of noradrenaline and adrenaline, vasopressor role in resistance arteries and maintenance of arterial blood pressure.","UniProtKB P35348","not stated on source page","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FP35348.json","2026-09-19",{"claims":21,"source":22,"licence":17,"source_url":23,"retrieved_at":19},"Class membership: 27 ingredients, including mirtazapine, trazodone, alfuzosin, doxazosin, tamsulosin, silodosin and labetalol.","RxNav RxClass class members (MED-RT), classId N0000009919","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000009919&relaSource=MEDRT&rela=has_MoA",{"claims":25,"source":26,"licence":17,"source_url":27,"retrieved_at":19},"Mirtazapine is also a has_MoA member of Adrenergic alpha2-Antagonists - the receipt that the alpha-1 \u002F alpha-2 exclusion is false.","RxNav RxClass class members (MED-RT), classId N0000009920","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000009920&relaSource=MEDRT&rela=has_MoA",[],[]]