[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$fqj7u5ip3b3sg":5},{"data":4},[],{"data":6,"error":11},{"id":7,"documentId":8,"slug":9,"name":10,"medical_code":11,"short_description":12,"alternate_name":11,"disambiguating_description":11,"citations":13,"drugs":32,"specialties":38,"cover":11},837,"vdes6doa5y811s068r8xw3qr","adrenergic-alpha2-agonists","Adrenergic alpha2-Agonists",null,"Alpha-2 adrenoceptors are G protein-coupled catecholamine receptors that activate the Gi\u002Fo pathway: they inhibit adenylyl cyclase, stimulate ERK1\u002F2 and suppress voltage-gated calcium channels, and presynaptically they mediate feedback inhibition of noradrenaline release from sympathetic and central nerve terminals. Drugs in this class activate that receptor. The FDA-approved veterinary label for dexmedetomidine describes it as a potent non-narcotic alpha-2 adrenoceptor agonist which produces sedation and analgesia, dose dependent in depth and duration, with an initial vasopressor response followed by a compensatory marked decrease in heart rate. A drug belongs here because it activates an alpha-2 receptor; that does not exclude alpha-1 activity, and MED-RT files dexmedetomidine under the alpha-1 agonist class as well.",[14,20,24,28],{"claims":15,"source":16,"licence":17,"source_url":18,"retrieved_at":19},"Gi\u002Fo coupling, adenylyl cyclase inhibition, ERK1\u002F2 stimulation, voltage-gated calcium channel suppression, presynaptic feedback inhibition of neurotransmitter release from noradrenergic terminals.","UniProtKB P08913","not stated on source page","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FP08913.json","2026-09-19",{"claims":21,"source":22,"licence":17,"source_url":23,"retrieved_at":19},"'Dexmedetomidine is a potent non-narcotic alpha 2 -adrenoceptor agonist which produces sedation and analgesia. These effects are dose dependent in depth and duration.' plus the initial vasopressor response with compensatory marked decrease in heart rate.","DailyMed SPL - Dexmedesed (dexmedetomidine hydrochloride) injection, Dechra Veterinary Products","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002Fservices\u002Fv2\u002Fspls\u002F6656444b-c4d8-48de-9548-fa61f2039d78.xml",{"claims":25,"source":26,"licence":17,"source_url":27,"retrieved_at":19},"Class membership: dexmedetomidine, clonidine, brimonidine, apraclonidine, guanfacine, guanabenz, lofexidine, tizanidine, xylometazoline.","RxNav RxClass class members (MED-RT), classId N0000009918","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000009918&relaSource=MEDRT&rela=has_MoA",{"claims":29,"source":30,"licence":17,"source_url":31,"retrieved_at":19},"Dexmedetomidine is also a has_MoA member of Adrenergic alpha1-Agonists - the receipt that the alpha-2 \u002F alpha-1 exclusion is false.","RxNav RxClass class members (MED-RT), classId N0000009917","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000009917&relaSource=MEDRT&rela=has_MoA",[33],{"id":34,"documentId":35,"slug":36,"name":37,"active_ingredient":37,"dosage_form":11,"administration_route":11},1591,"gk94wic9fe34oucxnh978yjm","dexmedetomidine","Dexmedetomidine",[]]