[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f2ucwkp5os2e29":5},{"data":4},[],{"data":6,"error":11},{"id":7,"documentId":8,"slug":9,"name":10,"medical_code":11,"short_description":12,"alternate_name":11,"disambiguating_description":11,"citations":13,"drugs":28,"specialties":38,"cover":11},839,"g4y7fgmsn10wrfwd8l4coaye","adrenergic-alpha2-antagonists","Adrenergic alpha2-Antagonists",null,"Alpha-2 adrenoceptors inhibit adenylyl cyclase through Gi\u002Fo, suppress voltage-gated calcium channels and damp presynaptic noradrenaline release. Drugs in this class occupy the receptor without activating it and so lift that inhibition. The FDA-approved veterinary label for atipamezole describes it as a potent alpha-2 antagonist which selectively and competitively inhibits alpha-2 adrenergic receptors, the result in the dog being rapid recovery from the sedative and analgesic effects produced by dexmedetomidine or medetomidine. A drug belongs here because it blocks an alpha-2 receptor, which is why atipamezole, the reversal agent for those two sedatives, sits in this class. As MED-RT populates it the class holds only four ingredients - atipamezole, celiprolol, mianserin and mirtazapine - and atipamezole is the only reversal agent among them.",[14,20,24],{"claims":15,"source":16,"licence":17,"source_url":18,"retrieved_at":19},"Gi\u002Fo coupling, adenylyl cyclase inhibition, voltage-gated calcium channel suppression, presynaptic feedback inhibition of noradrenaline release.","UniProtKB P08913","not stated on source page","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FP08913.json","2026-09-19",{"claims":21,"source":22,"licence":17,"source_url":23,"retrieved_at":19},"'Atipamezole is a potent alpha 2 -antagonist which selectively and competitively inhibits alpha 2 -adrenergic receptors. The result of atipamezole administration in the dog is the rapid recovery from the sedative and analgesic effects produced by the alpha 2 -adrenergic agonists dexmedetomidine or medetomidine.'","DailyMed SPL - Revertased (atipamezole hydrochloride) sterile injectable solution, Aspen Veterinary Resources","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002Fservices\u002Fv2\u002Fspls\u002F51410acc-da0c-4831-9e4e-01cb98c7b933.xml",{"claims":25,"source":26,"licence":17,"source_url":27,"retrieved_at":19},"Class membership: atipamezole, celiprolol, mianserin, mirtazapine - four ingredients, salts aside.","RxNav RxClass class members (MED-RT), classId N0000009920","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000009920&relaSource=MEDRT&rela=has_MoA",[29,33],{"id":30,"documentId":31,"slug":32,"name":32,"active_ingredient":11,"dosage_form":11,"administration_route":11},1749,"nvqc2wmngstm1al3n380cc08","mirtazapine",{"id":34,"documentId":35,"slug":36,"name":37,"active_ingredient":37,"dosage_form":11,"administration_route":11},1592,"i7izum1m03kpjiy5uef6fqh1","atipamezole","Atipamezole",[]]