[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f1wazt767z48aj":5},{"data":4},[],{"data":6,"error":11},{"id":7,"documentId":8,"slug":9,"name":10,"medical_code":11,"short_description":12,"alternate_name":11,"disambiguating_description":11,"citations":13,"drugs":32,"specialties":37,"cover":11},805,"o7qckvsm1rqc4syge2dngqs0","angiotensin-2-receptor-antagonists","Angiotensin 2 Receptor Antagonists",null,"Angiotensin II acts on the type-1 angiotensin II receptor (AT1), a G protein-coupled receptor that couples to Gq, activates phospholipase C and raises cytosolic calcium; it is a key regulator of blood pressure and of sodium retention by the kidney. Drugs in this class occupy that receptor without activating it: the FDA-approved label for telmisartan states that it blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in tissues such as vascular smooth muscle and the adrenal gland, so that its action is independent of the pathways for angiotensin II synthesis. The FDA-approved veterinary label for telmisartan oral solution calls it a selective AT1 receptor blocker with no relevant affinity for other receptors, indicated for the control of systemic hypertension in cats. A drug belongs here because it blocks the receptor, as distinct from an ACE inhibitor, which blocks the enzyme that makes the peptide; the class is the sartans, which UniProt records as strong inhibitors of this receptor.",[14,20,24,28],{"claims":15,"source":16,"licence":17,"source_url":18,"retrieved_at":19},"AT1 as receptor for angiotensin II, key regulator of blood pressure and sodium retention by the kidney; Gq coupling, phospholipase C activation, rise in cytosolic calcium; strong inhibition by losartan, candesartan, valsartan, irbesartan, telmisartan, eprosartan, olmesartan and azilsartan.","UniProtKB P30556","not stated on source page","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FP30556.json","2026-09-19",{"claims":21,"source":22,"licence":17,"source_url":23,"retrieved_at":19},"'Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT 1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis.'","DailyMed SPL - Telmisartan and hydrochlorothiazide tablets, AVKARE","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002Fservices\u002Fv2\u002Fspls\u002F1b303136-dccd-178b-e063-6394a90a35f8.xml",{"claims":25,"source":26,"licence":17,"source_url":27,"retrieved_at":19},"'Telmisartan is a selective angiotensin II subtype AT1 receptor blocker, with no relevant affinity for other receptors in general receptor-binding assays'; 'SEMINTRA is indicated for the control of systemic hypertension in cats.'","DailyMed SPL - SEMINTRA (telmisartan) oral solution, Boehringer Ingelheim Animal Health USA","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002Fservices\u002Fv2\u002Fspls\u002Ff436a826-9f5b-4269-b4ec-97d5522eaca6.xml",{"claims":29,"source":30,"licence":17,"source_url":31,"retrieved_at":19},"Class membership: azilsartan, candesartan, eprosartan, irbesartan, losartan, olmesartan, sparsentan, telmisartan, valsartan.","RxNav RxClass class members (MED-RT), classId N0000000070","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000000070&relaSource=MEDRT&rela=has_MoA",[33],{"id":34,"documentId":35,"slug":36,"name":36,"active_ingredient":11,"dosage_form":11,"administration_route":11},1815,"v8fsvevh1j96bwobu250mfqa","telmisartan",[]]