[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f2scqqpp48j0zo":5},{"data":4},[],{"data":6,"error":11},{"id":7,"documentId":8,"slug":9,"name":10,"medical_code":11,"short_description":12,"alternate_name":11,"disambiguating_description":11,"citations":13,"drugs":33,"specialties":44,"cover":11},821,"n8y6y5z022dv4l5dz3nt1iv4","chloride-channel-interactions","Chloride Channel Interactions",null,"This class is named for the target - a chloride channel - and not for the direction of the effect, and its members act at several different channels. Most are GABA-A drugs: the GABA-A receptor is a heteropentameric ligand-gated chloride channel with its GABA sites at the alpha\u002Fbeta subunit interfaces, and chloride influx through it after opening reduces the neuron's ability to generate an action potential. Benzodiazepines, the anaesthetic alphaxalone and pentobarbital act on it as allosteric activators rather than as agonists at the GABA site, while bicuculline is an antagonist. Other members act on epithelial chloride channels - lubiprostone, ivacaftor, lumacaftor, crofelemer, linaclotide. The macrocyclic lactones act at a different channel again: in the Caenorhabditis elegans glutamate-gated chloride channel, glutamate triggers a rapidly reversible current, whereas ivermectin and other avermectins trigger a permanently open channel configuration, with the ivermectin site at the interface of two glc-1 transmembrane domains.",[14,20,24,28],{"claims":15,"source":16,"licence":17,"source_url":18,"retrieved_at":19},"Glutamate-gated chloride channel subunit of C. elegans: glutamate triggers a rapidly reversible current in glc-1\u002Fglc-2 heteromers, while ivermectin and other avermectins trigger a permanently open channel configuration; role in regulation of locomotor behaviour.","UniProtKB G5EBR3","not stated on source page","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FG5EBR3.json","2026-09-19",{"claims":21,"source":22,"licence":17,"source_url":23,"retrieved_at":19},"GABA-A receptor as a heteropentameric ligand-gated chloride channel with GABA sites at alpha\u002Fbeta subunit interfaces; chloride influx reducing the neuron's ability to generate an action potential; allosteric activation by benzodiazepines, alphaxalone and pentobarbital; antagonism by bicuculline.","UniProtKB P14867","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FP14867.json",{"claims":25,"source":26,"licence":17,"source_url":27,"retrieved_at":19},"Class membership: 100 ingredients including alprazolam, diazepam, midazolam, isoflurane, desflurane, etomidate, ethanol, ganaxolone, flumazenil, ivermectin, moxidectin, lubiprostone, ivacaftor, lumacaftor, crofelemer, linaclotide.","RxNav RxClass class members (MED-RT), classId N0000000156","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000000156&relaSource=MEDRT&rela=has_MoA",{"claims":29,"source":30,"licence":31,"source_url":32,"retrieved_at":19},"'Ivermectin's mechanism ... acts on different pLGICs, glutamate-gated chloride channels (GluCls). The ivermectin binding site overlaps with a phospholipid ... binding site at the interface of two glc-1 TMDs.'","Sprague DJ, Marchant JS et al., 'Polypharmacology of anthelmintics at host and parasite ion channels' (Europe PMC PMC12923046)","Creative Commons Attribution License, as stated in the article","https:\u002F\u002Fwww.ebi.ac.uk\u002Feuropepmc\u002Fwebservices\u002Frest\u002FPMC12923046\u002FfullTextXML",[34,39],{"id":35,"documentId":36,"slug":37,"name":38,"active_ingredient":38,"dosage_form":11,"administration_route":11},1609,"f4vc8qvmmko7g8p8td6lr8z0","ivermectin","Ivermectin",{"id":40,"documentId":41,"slug":42,"name":43,"active_ingredient":43,"dosage_form":11,"administration_route":11},1610,"vt5y5l73bvbptwr7sdb4a8oz","moxidectin","Moxidectin",[]]