[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f1ef7xeg1n66ks":5},{"data":4},[],{"data":6,"error":11},{"id":7,"documentId":8,"slug":9,"name":10,"medical_code":11,"short_description":12,"alternate_name":11,"disambiguating_description":11,"citations":13,"drugs":25,"specialties":31,"cover":11},906,"qmxymc5qdhb4g25g4m4wynzp","cytochrome-p450-17a1-inhibitors","Cytochrome P450 17A1 Inhibitors",null,"CYP17A1 is the steroid 17-alpha-hydroxylase\u002F17,20-lyase, a cytochrome P450 of corticoid and androgen biosynthesis: it 17-alpha-hydroxylates C21 steroids, a step common to both pathways, and then performs the acyl-carbon cleavage that androgen synthesis additionally requires. Drugs in this class block that enzyme, so androgen and cortisol precursor supply falls. Unlike the drug-metabolising CYP classes, membership here is about suppressing steroid synthesis rather than about drug interactions.",[14,20],{"source":15,"licence":16,"source_url":17,"harvested_by":18,"retrieved_at":19},"RxClass (NLM)","US public domain","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002Fclass\u002FbyId.json?classId=N0000182632","load-reference-corpus.cjs","2026-09-13",{"source":21,"licence":22,"source_url":23,"harvested_by":18,"retrieved_at":24},"UniProt Knowledgebase entry P05093 (Steroid 17-alpha-hydroxylase\u002F17,20 lyase)","CC BY 4.0 (UniProt Consortium)","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FP05093.json","2026-09-16",[26],{"id":27,"documentId":28,"slug":29,"name":30,"active_ingredient":30,"dosage_form":11,"administration_route":11},1581,"qbx84ldo1uoc46l9sj7m129b","ketoconazole","Ketoconazole",[]]