[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$frawb41hj3dj9":5},{"data":4},[],{"data":6,"error":11},{"id":7,"documentId":8,"slug":9,"name":10,"medical_code":11,"short_description":12,"alternate_name":11,"disambiguating_description":11,"citations":13,"drugs":28,"specialties":33,"cover":11},913,"koqzf0328nlcqy95tz7qpi7q","cytochrome-p450-2c8-inducers","Cytochrome P450 2C8 Inducers",null,"CYP2C8 is a cytochrome P450 monooxygenase that oxidises fatty acids, steroid hormones and vitamins, inserting one atom of molecular oxygen into the substrate and reducing the second to water with two electrons supplied by NADPH through cytochrome P450 reductase. Drugs in this class induce it - UniProt records CYP2C8 as induced by phenobarbital - so a co-administered substrate of the pathway is cleared faster and its exposure falls. FDA grades that consequence and defines an inducer by it: strong and moderate index inducers decrease the AUC of sensitive substrates of a given metabolic pathway by at least 80 percent and by 50 to under 80 percent respectively. A drug belongs here because its recorded effect on CYP2C8 is induction, not inhibition; as MED-RT populates the class, its one member is nilotinib.",[14,20,24],{"claims":15,"source":16,"licence":17,"source_url":18,"retrieved_at":19},"CYP2C8 substrates (fatty acids, steroid hormones and vitamins) and the monooxygenase mechanism - one oxygen atom inserted into the substrate, the second reduced to water, two electrons from NADPH via cytochrome P450 reductase; INDUCTION: CYP2C8 as induced by phenobarbital.","UniProtKB P10632","not stated on source page","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FP10632.json","2026-09-19",{"claims":21,"source":22,"licence":17,"source_url":23,"retrieved_at":19},"'Strong and moderate index inducers are drugs that decrease the AUC of sensitive substrates of a given metabolic pathway by >=80 percent and >=50 to \u003C80 percent, respectively.' - the FDA definition of an inducer, stated as a fall in substrate exposure.","FDA, Drug Development and Drug Interactions | Table of Substrates, Inhibitors and Inducers","https:\u002F\u002Fwww.fda.gov\u002Fdrugs\u002Fdrug-interactions-labeling\u002Fdrug-development-and-drug-interactions-table-substrates-inhibitors-and-inducers",{"claims":25,"source":26,"licence":17,"source_url":27,"retrieved_at":19},"Class membership: nilotinib.","RxNav RxClass class members (MED-RT), classId N0000187063","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000187063&relaSource=MEDRT&rela=has_MoA",[29],{"id":30,"documentId":31,"slug":32,"name":32,"active_ingredient":11,"dosage_form":11,"administration_route":11},1769,"axusfveu24u0fdfhtc89rtbm","phenytoin",[]]