[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$feb7rvo9h0qjt":5},{"data":4},[],{"data":6,"error":11},{"id":7,"documentId":8,"slug":9,"name":10,"medical_code":11,"short_description":12,"alternate_name":11,"disambiguating_description":11,"citations":13,"drugs":32,"specialties":59,"cover":11},843,"fz5q3kb0a89c3m4grewa9a76","ergosterol-synthesis-inhibitors","Ergosterol Synthesis Inhibitors",null,"Ergosterol is the major sterol of the fungal membrane, and fungi build it through a late pathway whose reactions occur mainly in the endoplasmic reticulum membrane. Two enzymes of that pathway are drug targets: squalene epoxidase (ERG1), which catalyses the epoxidation of squalene to 2,3-epoxysqualene and is potently inhibited by the allylamines naftifine and SF 86-327 (terbinafine), and lanosterol 14-alpha-demethylase (ERG11, also known as CYP51), which catalyses the three-step oxidative removal of the 14-alpha-methyl group of lanosterol and eburicol and is inhibited by the azoles clotrimazole, miconazole, fluconazole and ketoconazole. Drugs acting at either enzyme stop ergosterol synthesis at that step. The class as MED-RT populates it is wider than its name: alongside the azoles and allylamines it holds the polyenes amphotericin B, nystatin and natamycin, which inhibit no enzyme of the pathway - the FDA-approved label for nystatin states that it acts by binding to sterols in the cell membrane of susceptible Candida species, with a resultant change in membrane permeability allowing leakage of intracellular components. For the polyene members the class name is a misnomer: they bind the ergosterol that has already been made.",[14,20,24,28],{"claims":15,"source":16,"licence":17,"source_url":18,"retrieved_at":19},"Candida albicans ERG1: 'Erg1 catalyzes the epoxidation of squalene into 2,3-epoxysqualene'; part of the third (late) module of ergosterol biosynthesis, occurring mainly in the ER membrane; 'The allylamine antimycotic agents naftifine and SF 86-327 are potent inhibitors'.","UniProtKB Q92206","not stated on source page","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FQ92206.json","2026-09-19",{"claims":21,"source":22,"licence":17,"source_url":23,"retrieved_at":19},"Candida albicans ERG11 (CYP51): sterol 14-alpha-demethylase catalysing 'the three-step oxidative removal of the 14alpha-methyl group (C-32)' of lanosterol and eburicol; ergosterol as the major sterol component of fungal membranes; catalytic activity inhibited by clotrimazole, miconazole, fluconazole, ketoconazole and other azoles.","UniProtKB P10613","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FP10613.json",{"claims":25,"source":26,"licence":17,"source_url":27,"retrieved_at":19},"'Nystatin acts by binding to sterols in the cell membrane of susceptible Candida species with a resultant change in membrane permeability allowing leakage of intracellular components.'","DailyMed SPL - Nystatin tablets, Preferred Pharmaceuticals","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002Fservices\u002Fv2\u002Fspls\u002F197e3046-3e58-4246-b260-f3995dce41a1.xml",{"claims":29,"source":30,"licence":17,"source_url":31,"retrieved_at":19},"Class membership: amphotericin B, natamycin and nystatin alongside the azoles (bifonazole, butoconazole, efinaconazole, itraconazole, ketoconazole, luliconazole, miconazole, oxiconazole, posaconazole, sertaconazole) and the allylamines butenafine, naftifine and terbinafine.","RxNav RxClass class members (MED-RT), classId N0000009957","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000009957&relaSource=MEDRT&rela=has_MoA",[33,37,41,45,49,54],{"id":34,"documentId":35,"slug":36,"name":36,"active_ingredient":11,"dosage_form":11,"administration_route":11},1748,"q9p0rfen34ydxqjuvp57cei2","miconazole",{"id":38,"documentId":39,"slug":40,"name":40,"active_ingredient":11,"dosage_form":11,"administration_route":11},1760,"uuqfvvb8r6vav0tbl4bv7ote","nystatin",{"id":42,"documentId":43,"slug":44,"name":44,"active_ingredient":11,"dosage_form":11,"administration_route":11},1775,"o22gwz6m14whtuiym53q8xt9","posaconazole",{"id":46,"documentId":47,"slug":48,"name":48,"active_ingredient":11,"dosage_form":11,"administration_route":11},1816,"gkaogu2pd8fvqp7k6t5f9vm8","terbinafine",{"id":50,"documentId":51,"slug":52,"name":53,"active_ingredient":53,"dosage_form":11,"administration_route":11},1582,"lajk1pbqxkppno24055pu4al","itraconazole","Itraconazole",{"id":55,"documentId":56,"slug":57,"name":58,"active_ingredient":58,"dosage_form":11,"administration_route":11},1581,"qbx84ldo1uoc46l9sj7m129b","ketoconazole","Ketoconazole",[]]