[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$fo8jy4fw2czeh":5},{"data":4},[],{"data":6,"error":11},{"id":7,"documentId":8,"slug":9,"name":10,"medical_code":11,"short_description":12,"alternate_name":11,"disambiguating_description":11,"citations":13,"drugs":28,"specialties":33,"cover":11},834,"pc367c5dcrbh1nbm2ffxi0kx","gaba-b-modulators","GABA B Modulators",null,"The GABA-B receptor is a heterodimeric G protein-coupled receptor built from a GABBR1 and a GABBR2 subunit: only GABBR1 appears to bind agonists, while GABBR2 mediates coupling to the G proteins, and signalling inhibits adenylate cyclase, activates potassium channels and inactivates voltage-dependent calcium channels. This class, however, has no verifiable content. UniProt Q9UBS5 carries no activity-regulation record and names no allosteric modulator of the receptor - only (-)-baclofen as an activator and phaclofen as a blocker - and the MED-RT class cited holds a single drug, secobarbital, which is also filed in the GABA-A modulator class N0000000118 and whose modulator action is at GABA-A. Until a drug with documented GABA-B allosteric modulation is placed here, this class should not be used to describe a mechanism.",[14,20,24],{"claims":15,"source":16,"licence":17,"source_url":18,"retrieved_at":19},"receptor architecture and signalling; the absence of any recorded allosteric modulator; activation by (-)-baclofen, block by phaclofen","UniProt Gamma-aminobutyric acid type B receptor subunit 1 (Q9UBS5)","not stated on source page","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FQ9UBS5.json","2026-09-19",{"claims":21,"source":22,"licence":17,"source_url":23,"retrieved_at":19},"the class holds only secobarbital and secobarbital sodium","RxClass \u002F MED-RT class members, GABA B Modulators (N0000000251)","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000000251&relaSource=MEDRT",{"claims":25,"source":26,"licence":17,"source_url":27,"retrieved_at":19},"secobarbital is also a member of the GABA-A modulator class","RxClass \u002F MED-RT class members, GABA A Modulators (N0000000118)","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000000118&relaSource=MEDRT",[29],{"id":30,"documentId":31,"slug":32,"name":32,"active_ingredient":11,"dosage_form":11,"administration_route":11},1794,"e075zsj2u5zoixwxnmq596js","secobarbital",[]]