[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f3vibeikny617v":5},{"data":4},[],{"data":6,"error":11},{"id":7,"documentId":8,"slug":9,"name":10,"medical_code":11,"short_description":12,"alternate_name":11,"disambiguating_description":11,"citations":13,"drugs":28,"specialties":33,"cover":11},831,"eqca5wv7zhbzgo09wdvxa3ox","histamine-receptor-antagonists","Histamine Receptor Antagonists",null,"This is the parent class for drugs said to block a histamine receptor of any subtype. Histamine acts through distinct G protein-coupled receptors with different clinical meaning: through H1 it contracts smooth muscle, increases capillary permeability and mediates central neurotransmission regulating circadian rhythms, emotional and locomotor activities and cognitive functions; through H2, predominantly in the gastric mucosa, it couples to Gs, raises cyclic AMP and drives parietal-cell hydrochloric acid secretion. The subtype blocked decides whether a drug is used as an antihistamine or as a gastric acid suppressant, so prefer the specific H1 or H2 class wherever the subtype is known. Note that the cited parent class is broader than its own name: among its 157 members are benztropine, hyoscyamine, scopolamine and methantheline, whose primary action is antimuscarinic, and pitolisant, an H3 inverse agonist rather than a plain antagonist.",[14,20,24],{"claims":15,"source":16,"licence":17,"source_url":18,"retrieved_at":19},"smooth-muscle contraction; increased capillary permeability; central neurotransmission regulating circadian rhythms, emotional and locomotor activities and cognitive functions","UniProt Histamine H1 receptor (P35367)","not stated on source page","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FP35367.json","2026-09-19",{"claims":21,"source":22,"licence":17,"source_url":23,"retrieved_at":19},"predominant gastric mucosal expression; Gs coupling, cAMP rise and parietal-cell hydrochloric acid secretion; antagonists are effective therapy for acid peptic disorders","UniProt Histamine H2 receptor (P25021)","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FP25021.json",{"claims":25,"source":26,"licence":17,"source_url":27,"retrieved_at":19},"the 157 members, which include benztropine, hyoscyamine, scopolamine, methantheline and pitolisant alongside the H1 and H2 antagonists","RxClass \u002F MED-RT class members, Histamine Receptor Antagonists (N0000000207)","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000000207&relaSource=MEDRT",[29],{"id":30,"documentId":31,"slug":32,"name":32,"active_ingredient":11,"dosage_form":11,"administration_route":11},1690,"yp2ogqwtw7q624wcjfxrdwn7","doxylamine",[]]