[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f324ggv8fj71a7":5},{"data":4},[],{"data":6,"error":11},{"id":7,"documentId":8,"slug":9,"name":10,"medical_code":11,"short_description":12,"alternate_name":11,"disambiguating_description":11,"citations":13,"drugs":28,"specialties":33,"cover":11},806,"x7n8gr0e4m7lex4kvru6nx6p","serotonin-5ht-3-antagonists","Serotonin 5HT-3 Antagonists",null,"The 5-HT3 receptor is unlike the other serotonin receptors: it is not G protein-coupled but a serotonin-gated, cation-selective ion channel, assembled as a homopentamer or as a heteropentamer with HTR3B, C, D or E, and when activated it causes fast, depolarising responses in neurons. Drugs in this class antagonise that channel. The ondansetron label sets out where that matters: 5-HT3 receptors are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema, and released serotonin may stimulate the vagal afferents through the 5-HT3 receptors and initiate the vomiting reflex; the label adds that it is not certain whether the antiemetic action is mediated centrally, peripherally or at both sites. The class is not uniformly antiemetic - alongside dolasetron, granisetron, ondansetron and palonosetron the cited list also holds trazodone, mirtazapine and vortioxetine, whose principal indications are not antiemetic.",[14,20,24],{"claims":15,"source":16,"licence":17,"source_url":18,"retrieved_at":19},"alternative name 'Serotonin-gated ion channel receptor'; forms serotonin-activated cation-selective channel complexes which when activated cause fast, depolarizing responses in neurons; forms homopentameric as well as heteropentameric complexes with HTR3B, HTR3C, HTR3D or HTR3E","UniProt 5-hydroxytryptamine receptor 3A (P46098)","not stated on source page","https:\u002F\u002Frest.uniprot.org\u002Funiprotkb\u002FP46098.json","2026-09-19",{"claims":21,"source":22,"licence":17,"source_url":23,"retrieved_at":19},"ondansetron is a selective 5-HT3 receptor antagonist; 5-HT3 receptors are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema; it is not certain whether the antiemetic action is mediated centrally, peripherally or at both sites; released serotonin may stimulate the vagal afferents through the 5-HT3 receptors and initiate the vomiting reflex","DailyMed SPL, Ondansetron hydrochloride film-coated tablets, RemedyRepack","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=960e2104-18c3-4cfa-abf6-f1b30c452918",{"claims":25,"source":26,"licence":17,"source_url":27,"retrieved_at":19},"the 15 members: dolasetron, granisetron, ondansetron, palonosetron, trazodone, mirtazapine and vortioxetine salts","RxClass \u002F MED-RT class members, Serotonin 5HT-3 Antagonists (N0000000090)","https:\u002F\u002Frxnav.nlm.nih.gov\u002FREST\u002Frxclass\u002FclassMembers.json?classId=N0000000090&relaSource=MEDRT",[29],{"id":30,"documentId":31,"slug":32,"name":32,"active_ingredient":11,"dosage_form":11,"administration_route":11},1749,"nvqc2wmngstm1al3n380cc08","mirtazapine",[]]