[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f3piyjv8xn8xh1":5},{"data":4},[],{"data":6,"error":10},{"id":7,"documentId":8,"slug":9,"name":9,"proprietary_name":10,"non_proprietary_name":10,"is_proprietary":10,"active_ingredient":10,"administration_route":10,"available_strength":10,"dosage_form":10,"dose_schedule":10,"drug_unit":10,"is_available_generically":10,"mechanism_of_action":10,"overdosage":10,"warning":10,"species":11,"citations":12,"dose_schedules":19,"available_strengths":50,"label_statements":66,"drug_classes":96,"specialties":107,"medical_conditions":108,"animal_species":114},1630,"os01su5kbg4lm7w02rgqblrl","amikacin",null,[],[13],{"source":14,"licence":15,"source_url":16,"harvested_by":17,"retrieved_at":18},"FDA Green Book","US public domain","https:\u002F\u002Fanimaldrugsatfda.fda.gov\u002Fadafda\u002Fapp\u002Fsearch\u002Fpublic\u002FingredientsInformationExcel\u002FSection2ActiveIngredients","load-reference-corpus.cjs","2026-09-07",[20,27,33,40,45],{"id":21,"dose_text":22,"species":23,"administration_route":24,"limitation":25,"source_label":26},11172,"5 milligrams per pound of body weight twice daily. The drug is administered intramuscularly or subcutaneously.","Dogs","Intramuscular, Subcutaneous","Treat dogs with skin and soft tissue infections for a minimum of 7 days and those with genitourinary infections for 78 to 21 days or until culture is negative and asymptomatic. If no response is observed after 3 days of treatment, therapy should be discontinued and the case reevaluated. Maximum duration of therapy should not exceed 30 days. Systemic aminoglycoside therapy is contraindicated in dogs with seriously impaired renal function. Not for use in breeding dogs as reproductive studies have not been conducted. Use with extreme caution in dogs in which hearing acuity is required for functioning. Federal law restricts this drug to use by or on the order of a licensed veterinarian.","Amikacin Sulfate Injection",{"id":28,"dose_text":29,"species":23,"administration_route":30,"limitation":31,"source_label":32},11173,"5 milligrams per pound of body weight twice daily.","Intramuscular, Intrauterine, Subcutaneous","The drug is administered intramuscularly or subcutaneously. Treat dogs with skin and soft tissue infections for a minimum of 7 days and those with genitourinary infections for 78 to 21 days or until culture is negative and asymptomatic. If no response is observed after 3 days of treatment, therapy should be discontinued and the case reevaluated. Maximum duration of therapy should not exceed 30 days. Systemic aminoglycoside therapy is contraindicated in dogs with seriously impaired renal function. Not for use in breeding dogs as reproductive studies have not been conducted. Use with extreme caution in dogs in which hearing acuity is required for functioning. Federal law restricts this drug to use by or on the order of a licensed veterinarian.","Amiglyde-V",{"id":34,"dose_text":35,"species":36,"administration_route":37,"limitation":38,"source_label":39},11174,"2 grams (8 milliliters) diluted with 200 milliliters of sterile physiological saline per day for 3 consecutive days.","Horses","Intrauterine","Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.","AmiMax™ E Solution",{"id":41,"dose_text":42,"species":43,"administration_route":30,"limitation":44,"source_label":32},11175,"Two grams (8 milliliters) diluted with 200 milliliters of sterile physiological saline per day for 3 consecutive days.","Horses (mares)","For intrauterine infusion in the horse only. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.",{"id":46,"dose_text":47,"species":10,"administration_route":48,"limitation":10,"source_label":49},11176,"For treatment of uterine infections in mares, 2 grams\n(8 mL) of AMIGLYDE-V, mixed with 200 mL 0.9% Sodium chloride injection, USP and aseptically infused\ninto the uterus daily for three consecutive days, has been found to be the most efficacious dosage.","INTRAUTERINE","Amiglyde-V® (amikacin sulfate injection)Veterinary SolutionEquivalent to 250 mg amikacin per mL",[51,55,58,61,63],{"id":52,"strength_text":53,"dosage_form":54,"proprietary_name":26,"species":23,"source_label":26},9807,"Each milliliter of sterile aqueous solution contains 50 milligrams of amikacin (as the sulfate).","Liquid (Solution)",{"id":56,"strength_text":57,"dosage_form":54,"proprietary_name":39,"species":36,"source_label":39},9808,"Each milliliter of sterile aqueous solution contains 250 milligrams of amikacin (as the sulfate).",{"id":59,"strength_text":60,"dosage_form":54,"proprietary_name":32,"species":43,"source_label":32},9809,"Each milliliter of sterile aqueous solution contains 50 milligrams or 250 milligrams of amikacin (as the sulfate).",{"id":62,"strength_text":60,"dosage_form":54,"proprietary_name":32,"species":23,"source_label":32},9810,{"id":64,"strength_text":65,"dosage_form":10,"proprietary_name":10,"species":10,"source_label":49},9811,"250 mg \u002F 1 mL",[67,71,74,77,80,84,88,92],{"id":68,"kind":69,"statement":70,"species":23,"limitation":31,"source_label":32},16114,"indication","The drug is used in dogs for treatment of genitourinary tract infections (cystitis) caused by susceptible strains of Escherichia coli and Proteus species and skin and soft tissue infections caused by susceptible strains of Pseudomonas species and E. coli.",{"id":72,"kind":69,"statement":73,"species":36,"limitation":38,"source_label":39},16115,"For treating genital tract infections (endometritis, metritis, and pyometra) in mares caused by susceptible organisms including Escherichia coli, Pseudomonas spp., and Klebsiella spp.",{"id":75,"kind":69,"statement":76,"species":43,"limitation":44,"source_label":32},16116,"For treating genital tract infections (endometritis, metritis, and pyometra) in mares when caused by susceptible organisms including E. coli, Pseudomonas species, and Klebsiella species.",{"id":78,"kind":69,"statement":79,"species":10,"limitation":10,"source_label":49},16117,"AMIGLYDE-V is indicated for the treatment of uterine\ninfections (endometritis, metritis and pyometra) in mares, when caused by susceptible organisms\nincluding Escherichia coli, Pseudomonas sp and Klebsiella sp. The use of AMIGLYDE-V in eliminating\ninfections caused by the above organisms has been shown clinically to improve fertility in infected\nmares.\nWhile nearly all strains of Escherichia coli,\nPseudomonas sp and Klebsiella sp, including those that are resistant to gentamicin, kanamycin or other\naminoglycosides, are susceptible to amikacin at levels achieved following treatment, it is\nrecommended that the invading organism be cultured and its susceptibility demonstrated as a guide\nto therapy. Amikacin susceptibility discs, 30 mcg, should be used for determining in vitro susceptibility.",{"id":81,"kind":82,"statement":83,"species":10,"limitation":10,"source_label":49},16118,"contraindication","There are no known contraindications for the use of\nAMIGLYDE-V in horses other than a history of hypersensitivity to amikacin.",{"id":85,"kind":86,"statement":87,"species":10,"limitation":10,"source_label":49},16119,"warning","Do not use in horses intended for human consumption.\nIn vitro studies have demonstrated that when sperm are exposed to the preservative which is present in the 48 mL\nvials (250 mg\u002FmL) sperm viability is impaired.",{"id":89,"kind":90,"statement":91,"species":10,"limitation":10,"source_label":49},16120,"adverse_reaction","No adverse reactions or other side effects have been reported.",{"id":93,"kind":94,"statement":95,"species":10,"limitation":10,"source_label":49},16121,"mechanism_of_action","Endometrial Tissue Concentrations\nComparisons of amikacin activity in endometrial biopsy tissue following intrauterine infusion with\nthat following intramuscular injection of AMIGLYDE-V in mares demonstrate superior endometrial\ntissue concentrations when the drug is administered by\nthe intrauterine route.\nIntrauterine infusion of 2 grams AMIGLYDE-V daily for three consecutive days in mares results in\npeak concentrations typically exceeding 40 mcg\u002Fg of endometrial biopsy tissue within one hour after\ninfusion. Twenty-four hours after each treatment amikacin activity is still detectable at\nconcentrations averaging 2 to 4 mcg\u002Fg. However, the drug is not appreciably absorbed systemically\nfollowing intrauterine infusion. Endometrial tissue concentrations following intramuscular\ninjection are roughly parallel, but are typically somewhat lower\nthan corresponding serum concentrations of amikacin.",[97,102],{"id":98,"documentId":99,"slug":100,"name":101},757,"sy8j3qgjaw7a59jnlri1afy8","aminoglycosides","Aminoglycosides",{"id":103,"documentId":104,"slug":105,"name":106},858,"n7ytl9aglp193ipwlqngy8hz","aminoglycoside-antibacterial","Aminoglycoside Antibacterial",[],[109],{"id":110,"documentId":111,"slug":112,"title":113},115,"qsinaxvmzakywujz5lx1hjzp","cystitis","Cystitis",[]]