[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f3ad37ix2wzm04":5},{"data":4},[],{"data":6,"error":10},{"id":7,"documentId":8,"slug":9,"name":9,"proprietary_name":10,"non_proprietary_name":10,"is_proprietary":10,"active_ingredient":10,"administration_route":10,"available_strength":10,"dosage_form":10,"dose_schedule":10,"drug_unit":10,"is_available_generically":10,"mechanism_of_action":10,"overdosage":10,"warning":10,"species":11,"citations":12,"dose_schedules":23,"available_strengths":133,"label_statements":182,"drug_classes":284,"specialties":290,"medical_conditions":291,"animal_species":302},1857,"aeu2i2yvxizaj0vi2u38rwtz","dinoprost",null,[],[13,19],{"source":14,"licence":15,"source_url":16,"harvested_by":17,"retrieved_at":18},"FDA Green Book","US public domain","https:\u002F\u002Fanimaldrugsatfda.fda.gov\u002Fadafda\u002Fapp\u002Fsearch\u002Fpublic\u002FingredientsInformationExcel\u002FSection2ActiveIngredients","load-reference-corpus.cjs","2026-09-07",{"source":20,"licence":21,"source_url":22,"harvested_by":17,"retrieved_at":18},"UK VMD PID","OGL v3.0","https:\u002F\u002Fwww.vmd.defra.gov.uk\u002Fproductinformationdatabase\u002Fdownloads\u002Fvmd_productinformationdatabase.xlsx",[24,30,34,37,40,44,48,52,56,60,65,70,73,78,82,85,88,92,95,98,105,108,112,116,120,125,129],{"id":25,"dose_text":26,"species":27,"administration_route":28,"limitation":10,"source_label":29},13696,"ProstaMate is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 5 mL ProstaMate (25 mg dinoprost) intramuscularly either once or twice at a 10 to 12 day interval. With the single injection, cattle should be bred at the usual time relative to estrus. With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of ProstaMate. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days.","Cattle (beef cows, beef heifers, and replacement dairy heifers)","Intramuscular","ProstaMate®",{"id":31,"dose_text":32,"species":33,"administration_route":28,"limitation":10,"source_label":29},13697,"Administer 2 to 4 mL gonadorelin injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework:\nAdminister the first dose of gonadorelin injection (2-4 mL) at Day 0\nAdminister ProstaMate® (25 mg dinoprost, as dinoprost tromethamine) by intramuscular injection 6-8 days after the first dose of gonadorelin injection.\nAdminister a second dose of gonadorelin injection (2-4 mL) 30 to 72 hours after the ProstaMate® injection.\nPerform FTAI 0 to 24 hours after the second dose of gonadorelin injection, or inseminate cows on detected estrus using standard herd practices.","Cattle (lactating dairy cows)",{"id":35,"dose_text":36,"species":33,"administration_route":28,"limitation":10,"source_label":29},13698,"Administer one EAZI-BREED™ CIDR® Cattle Insert per animal and remove 7 days later (for example if administered on a Monday remove the following Monday).\nAdminister 5 mL ProstaMate® at the time of removal of the EAZI-BREED™ CIDR® Cattle Insert.\nObserve animals for signs of estrus on Days 2 to 5 after removal of the EAZI-BREED™ CIDR® Cattle Insert and inseminate animals found in estrus following normal herd practices.",{"id":38,"dose_text":39,"species":33,"administration_route":28,"limitation":10,"source_label":29},13699,"Inject a dose of 5 mL ProstaMate (25 mg dinoprost) intramuscularly. Breed cows as they are detected in estrus. If estrus has not been observed by 80 hours after injection, breed at 80 hours. If the cow returns to estrus, breed at the usual time relative to estrus.",{"id":41,"dose_text":42,"species":43,"administration_route":28,"limitation":10,"source_label":29},13700,"Inject a dose of 5 mL ProstaMate (25 mg dinoprost) intramuscularly.","Cattle (beef cows, dairy cows, beef heifers and replacement dairy heifers)",{"id":45,"dose_text":46,"species":47,"administration_route":28,"limitation":10,"source_label":29},13701,"ProstaMate® is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Inject a dose of 25 mg dinoprost (5 mL) intramuscularly. Cattle that abort will abort within 35 days of injection.","Cattle (beef cows, beef heifers and replacement dairy heifers)",{"id":49,"dose_text":50,"species":51,"administration_route":28,"limitation":10,"source_label":29},13702,"Administer one EAZI-BREED™ CIDR® Cattle Insert per animal for 7 days (for example, if administered on a Monday remove on the following Monday).\nInject 5 mL ProstaMate (equivalent to 5 mg\u002FmL dinoprost) 1 day prior to EAZI-BREED™ CIDR® Cattle Insert removal, on Day 6 of the 7 day administration period.\nObserve animals for signs of estrus on Days 1 to 3 after removal of the EAZI-BREED™ CIDR® Cattle Insert and inseminate animals about 12 hours after onset of estrus.","Cattle (beef cows, replacement beef and dairy heifers)",{"id":53,"dose_text":54,"species":55,"administration_route":28,"limitation":10,"source_label":29},13703,"For intramuscular use for parturition induction in swine. ProstaMate is indicated for parturition induction in swine when injected within 3 days of normal predicted farrowing. The response to treatment varies by individual animals with a mean interval from administration of 2 mL ProstaMate (10 mg dinoprost) to parturition of approximately 30 hours. This can be employed to control the time of arrowing in sows and gilts in late gestation.","Swine (gilts and sows)",{"id":57,"dose_text":58,"species":59,"administration_route":28,"limitation":10,"source_label":29},13704,"Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2 mL ProstaMate.","Horses (mares)",{"id":61,"dose_text":62,"species":59,"administration_route":28,"limitation":63,"source_label":64},13705,"Equivalent of 1 milligram of dinoprost per 100 pounds of body weight. For use once as a single intramuscular injection.","Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Women of child-bearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water. Use of this product in excess of the approved dose may result in drug residues. Do not administer intravenously; this may potentiate adverse reactions.","Prostin F2 Alpha® Sterile Solution",{"id":66,"dose_text":67,"species":68,"administration_route":28,"limitation":10,"source_label":69},13706,"LUTALYSE Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly either once or twice at a 10 to 12 day interval. With the single injection, cattle should be bred at the usual time relative to estrus. With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days.","Beef Cows, Beef Heifers and Replacement Dairy Heifers","Lutalyse® Injection",{"id":71,"dose_text":72,"species":68,"administration_route":28,"limitation":10,"source_label":69},13707,"Inject a dose of 25 mg dinoprost (5 mL) intramuscularly during the first 100 days of gestation. Cattle that abort will abort within 35 days of injection.",{"id":74,"dose_text":75,"species":10,"administration_route":76,"limitation":10,"source_label":77},13708,"As with any multi-dose vial, practice aseptic techniques in withdrawing each dose to decrease the possibility of post- injection bacterial infections. Adequately clean and disinfect the vial stopper prior to entry with a sterile needle and syringe. Use only sterile needles, and use each needle only once. No vial stopper should be entered more than 20 times.\n1. For Estrus Synchronization in Beef Cows, Beef Heifers and Replacement Dairy Heifers. LUTALYSE HighCon Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) intramuscularly or subcutaneously either once or twice at a 10 to 12 day interval. With the single injection, cattle should be bred at the usual time relative to estrus. With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE HighCon Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days.\n2. For Unobserved (Silent) Estrus in Lactating Dairy Cows with a Corpus Luteum. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection. Breed cows as they are detected in estrus. If estrus has not been observed by 80 hours after injection, breed at 80 hours. If the cow returns to estrus, breed at the usual breed at the usual time relative to estrus.\n3. For Treatment of Pyometra (chronic endometritis) in Cattle. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection.\n4. For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers. LUTALYSE HighCon Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection. Cattle that abort will abort within 35 days of injection.\n5. For use with FACTREL® (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: Administer 2 to 4 mL FACTREL Injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework:\n• Administer the first dose of FACTREL Injection (2-4 mL) at Day 0\n• Administer a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection 6-8 days after the first dose of FACTREL Injection.\n• Administer a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE HighCon Injection.\n• Perform FTAI 0 to 24 hours after the second dose of FACTREL Injection, or inseminate cows on detected estrus using standard herd practices.\nBelow are three examples of treatment regimens for the dosage regimen framework described immediately above:\nExample 1\nExample 2\nExample 3\nDay 0 (Monday)\n1st Factrel\n1st Factrel\n1st Factrel\nDay 7 (the following Monday)\nLUTALYSE\nHighCon\nLUTALYSE\nHighCon\nLUTALYSE\nHighCon\nDay 9 (Wednesday)\n2nd Factrel\n+ FTAI at 48 hours\nafter\nLUTALYSE\nHighCon\n2nd Factrel\nat 48 hours\nafter\nLUTALYSE\nHighCon\n2nd Factrel\nat 56 hours\nafter\nLUTALYSE\nHighCon\nDay 10 (Thursday)\nFTAI\n24 hours\nafter 2nd FACTREL\nFTAI\n18 hours\nafter 2nd FACTREL\n6. For use with EAZI-BREED™ CIDR® (progesterone intravaginal insert) Cattle Insert for Synchronization of Estrus in Lactating Dairy Cows:\n• Administer one EAZI-BREED CIDR Cattle Insert per animal and remove 7 days later (for example if administered on a Monday remove the following Monday).\n• Administer a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular subcutaneous injection at the time of removal of the EAZI-BREED CIDR Cattle Insert.\n• Observe animals for signs of estrus on Days 2 to 5 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals found in estrus following normal herd practices.\n7. For use with EAZI-BREED™ CIDR® (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers:\n• Administer one EAZI-BREED CIDR Cattle Insert per animal for 7 days (for example, if administered on a Monday remove on the following Monday).\n• Administer a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection 1 day prior to EAZI-BREED CIDR Cattle Insert removal, on Day 6 of the 7 day administration period.\n• Observe animals for signs of estrus on Days 1 to 3 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals about 12 hours after onset of estrus.","INTRAMUSCULAR","Lutalyse® HighCon",{"id":79,"dose_text":80,"species":10,"administration_route":76,"limitation":10,"source_label":81},13709,"DOSAGE AND ADMINISTRATION\nAs with any multi-dose vial, practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. Adequately clean and disinfect the vial stopper prior to entry with a sterile needle and syringe. Use only sterile needles, and use each needle only once.\nUse within 3 months of first puncture and puncture a maximum of 20 times with a needle or 5 times with a dosage delivery device. When using a draw-off spike or needle with bore diameter larger than 4.90 mm, discard any product remaining in the vial immediately after use.","ProstaMate™(dinoprost tromethamine)Sterile Solution",{"id":83,"dose_text":84,"species":10,"administration_route":76,"limitation":10,"source_label":69},13710,"As with any multi-dose vial, practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. Adequately clean and disinfect the vial stopper prior to entry with a sterile needle and syringe. Use only sterile needles, and use each needle only once.\nNo vial stopper should be entered more than 20 times. For this reason, the 100 mL bottle should only be used for cattle. The 30 mL bottle may be used for cattle, swine, or mares.",{"id":86,"dose_text":87,"species":10,"administration_route":28,"limitation":10,"source_label":69},13711,"Administer one EAZI-BREED CIDR Cattle Insert per animal for 7 days (for example, if administered on a Monday remove on the following Monday).\nInject 5 mL LUTALYSE Injection (equivalent to 5 mg\u002FmL dinoprost) 1 day prior to EAZI-BREED CIDR Cattle Insert removal, on Day 6 of the 7 day administration period.\nObserve animals for signs of estrus on Days 1 to 3 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals about 12 hours after onset of estrus.",{"id":89,"dose_text":90,"species":91,"administration_route":28,"limitation":10,"source_label":69},13712,"Administer 2 to 4 mL FACTREL Injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework:\nAdminister the first dose of FACTREL Injection (2-4 mL) at Day 0\nAdminister LUTALYSE (25 mg dinoprost, as dinoprost tromethamine) Injection by intramuscular injection 6-8 days after the first dose of FACTREL Injection.\nAdminister a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE injection.\nPerform FTAI 0 to 24 hours after the second dose of FACTREL Injection, or inseminate cows on detected estrus using standard herd practices.","Lactating Dairy Cows",{"id":93,"dose_text":94,"species":91,"administration_route":28,"limitation":10,"source_label":69},13713,"Administer one EAZI-BREED CIDR Cattle Insert per animal and remove 7 days later (for example if administered on a Monday remove the following Monday).\nAdminister 5 mL LUTALYSE Injection at the time of removal of the EAZI-BREED CIDR Cattle Insert.\nObserve animals for signs of estrus on Days 2 to 5 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals found in estrus following normal herd practices.",{"id":96,"dose_text":97,"species":91,"administration_route":28,"limitation":10,"source_label":69},13714,"Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly. Breed cows as they are detected in estrus. If estrus has not been observed by 80 hours after injection, breed at 80 hours. If the cow returns to estrus, breed at the usual time relative to estrus.",{"id":99,"dose_text":100,"species":101,"administration_route":102,"limitation":103,"source_label":104},13715,"Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection.","Cattle","Intramuscular, Subcutaneous","Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and\u002For bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water.","LUTALYSE® HighCon Injection",{"id":106,"dose_text":107,"species":101,"administration_route":28,"limitation":10,"source_label":69},13716,"Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly.",{"id":109,"dose_text":110,"species":111,"administration_route":28,"limitation":10,"source_label":69},13717,"Inject intramuscularly within 3 days of normal predicted farrowing. The response to treatment varies by individual animals with a mean interval from administration of 2 mL LUTALYSE Injection (10 mg dinoprost) to parturition of approximately 30 hours. This can be employed to control the time of farrowing in sows and gilts in late gestation. Do not administer to sows and\u002For gilts prior to 3 day of normal predicted farrowing as an increased number of stillbirths and postnatal mortality may result.","Swine (sows and gilts)",{"id":113,"dose_text":114,"species":115,"administration_route":28,"limitation":10,"source_label":69},13718,"Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2 mL LUTALYSE Injection. This luteolytic effect can be utilized to control the timing of estrus in estrous cycling and clinically anestrous mares that have a corpus luteum","Horse (mares)",{"id":117,"dose_text":100,"species":118,"administration_route":102,"limitation":119,"source_label":104},13719,"Cattle (Suckled Beef Cows, Replacement Beef and Dairy Heifers)","Administer one EAZI-BREED CIDR Cattle Insert per animal for 7 days (for example, if administered on a Monday remove on the following Monday). Administer a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection 1 day prior to EAZI-BREED CIDR Cattle Insert removal, on Day 6 of the 7 Day administration period. Observe animals for signs of estrus on Days 1 to 3 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals about 12 hours after onset of estrus. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, or persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and\u002For bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water.",{"id":121,"dose_text":122,"species":123,"administration_route":102,"limitation":124,"source_label":104},13720,"Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) intramuscularly or subcutaneously either once or twice at a 10 to 12 day interval.","Cattle (Beef Cows, Beef Heifers, Replacement Dairy Heifers)","LUTALYSE HighCon Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. With the single injection, cattle should be bred at the usual time relative to estrus. With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE HighCon Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and\u002For bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water.",{"id":126,"dose_text":127,"species":123,"administration_route":102,"limitation":128,"source_label":104},13721,"Inject a dose of 25 mg (2 mL) by intramuscular or subcutaneous injection.","LUTALYSE HighCon Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Cattle that abort will abort within 35 days of injection. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, or persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and\u002For bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water.",{"id":130,"dose_text":100,"species":131,"administration_route":102,"limitation":132,"source_label":104},13722,"Cattle (Lactating Dairy Cows)","Administer one EAZI-BREED CIDR Cattle Insert per animal and remove 7 days later (for example, if administered on a Monday remove the following Monday). Administer a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection at the time of removal of the EAZI-BREED CIDR Cattle Insert. Observe animals for signs of estrus on Days 2 to 5 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals found in estrus following normal herd practices. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, or persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and\u002For bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water.",[134,138,140,142,144,146,148,150,153,155,157,159,161,163,167,170,172,174,176,179],{"id":135,"strength_text":136,"dosage_form":137,"proprietary_name":29,"species":27,"source_label":29},11908,"5 mg dinoprost\u002FmL as dinoprost tromethamine","Injectable Solution",{"id":139,"strength_text":136,"dosage_form":137,"proprietary_name":29,"species":33,"source_label":29},11909,{"id":141,"strength_text":136,"dosage_form":137,"proprietary_name":29,"species":43,"source_label":29},11910,{"id":143,"strength_text":136,"dosage_form":137,"proprietary_name":29,"species":47,"source_label":29},11911,{"id":145,"strength_text":136,"dosage_form":137,"proprietary_name":29,"species":51,"source_label":29},11912,{"id":147,"strength_text":136,"dosage_form":137,"proprietary_name":29,"species":55,"source_label":29},11913,{"id":149,"strength_text":136,"dosage_form":137,"proprietary_name":29,"species":59,"source_label":29},11914,{"id":151,"strength_text":152,"dosage_form":137,"proprietary_name":69,"species":68,"source_label":69},11915,"Each milliliter of sterile solution contains the equivalent of 5 milligrams of dinoprost.",{"id":154,"strength_text":152,"dosage_form":137,"proprietary_name":69,"species":10,"source_label":69},11916,{"id":156,"strength_text":152,"dosage_form":137,"proprietary_name":69,"species":91,"source_label":69},11917,{"id":158,"strength_text":152,"dosage_form":137,"proprietary_name":69,"species":101,"source_label":69},11918,{"id":160,"strength_text":152,"dosage_form":137,"proprietary_name":69,"species":111,"source_label":69},11919,{"id":162,"strength_text":152,"dosage_form":137,"proprietary_name":69,"species":115,"source_label":69},11920,{"id":164,"strength_text":165,"dosage_form":166,"proprietary_name":64,"species":59,"source_label":64},11921,"522.690 Dinoprost tromethamine sterile solution.\nSpecifications:\nEach milliliter of sterile solution contains the equivalent of 5 milligrams of dinoprost.\nConditions of use:\nHorses (mares)\nAmount:\nEquivalent of 1 milligram of dinoprost per 100 pounds of body weight. For use once as a single intramuscular injection.\nIndications:\nFor its luteolytic effect to control timing of estrus in estrus cycling mares and in clinically anestrous mares that have a corpus luteum.\nLimitations:\nNot for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Women of child-bearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water. Use of this","Liquid (Solution)",{"id":168,"strength_text":169,"dosage_form":137,"proprietary_name":104,"species":118,"source_label":104},11922,"12.5 mg dinoprost\u002FmL as dinoprost tromethamine",{"id":171,"strength_text":169,"dosage_form":137,"proprietary_name":104,"species":123,"source_label":104},11923,{"id":173,"strength_text":169,"dosage_form":137,"proprietary_name":104,"species":101,"source_label":104},11924,{"id":175,"strength_text":169,"dosage_form":137,"proprietary_name":104,"species":131,"source_label":104},11925,{"id":177,"strength_text":178,"dosage_form":10,"proprietary_name":10,"species":10,"source_label":77},11926,"12.5 mg \u002F 1 mL",{"id":180,"strength_text":181,"dosage_form":10,"proprietary_name":10,"species":10,"source_label":69},11927,"5 mg \u002F 1 mL",[183,187,190,193,196,199,202,205,208,211,214,217,220,223,226,229,232,235,237,240,243,246,248,250,254,257,260,264,267,270,274,277,281],{"id":184,"kind":185,"statement":186,"species":27,"limitation":10,"source_label":29},20091,"indication","For estrus synchronization in beef cows, beef heifers and replacement dairy heifers.",{"id":188,"kind":185,"statement":189,"species":33,"limitation":10,"source_label":29},20092,"For use with gonadorelin injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows.",{"id":191,"kind":185,"statement":192,"species":33,"limitation":10,"source_label":29},20093,"For use with EAZI-BREED™ CIDR® (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in lactating dairy cows.",{"id":194,"kind":185,"statement":195,"species":33,"limitation":10,"source_label":29},20094,"For unobserved (silent) estrus in lactating dairy cows with a corpus luteum.",{"id":197,"kind":185,"statement":198,"species":43,"limitation":10,"source_label":29},20095,"For treatment of pyometra (chronic endometritis) in cattle.",{"id":200,"kind":185,"statement":201,"species":47,"limitation":10,"source_label":29},20096,"For abortion in beef cows, beef heifers and replacement dairy heifers.",{"id":203,"kind":185,"statement":204,"species":51,"limitation":10,"source_label":29},20097,"For use with EAZI-BREED™ CIDR® (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers.",{"id":206,"kind":185,"statement":207,"species":55,"limitation":10,"source_label":29},20098,"For parturition induction in swine.",{"id":209,"kind":185,"statement":210,"species":59,"limitation":10,"source_label":29},20099,"For controlling the timing of estrus in estrous cycling mares and for difficult-to-breed mares (clinically anestrous mares that have a corpus luteum).",{"id":212,"kind":185,"statement":213,"species":59,"limitation":63,"source_label":64},20100,"For its luteolytic effect to control timing of estrus in estrus cycling mares and in clinically anestrous mares that have a corpus luteum.",{"id":215,"kind":185,"statement":216,"species":68,"limitation":10,"source_label":69},20101,"For estrus synchronization in beef cows, beef heifers and replacement dairy heifers",{"id":218,"kind":185,"statement":219,"species":68,"limitation":10,"source_label":69},20102,"For abortion in beef cows, beef heifers and replacement dairy heifers",{"id":221,"kind":185,"statement":222,"species":10,"limitation":10,"source_label":77},20103,"LUTALYSE HighCon Injection is indicated as a luteolytic agent. LUTALYSE HighCon Injection is effective only in those cattle having a corpus luteum, i.e., those which ovulated at least five days prior to treatment.\n• For estrus synchronization in beef cows, beef heifers and replacement dairy heifers\n• For unobserved (silent) estrus in lactating dairy cows with a corpus luteum\n• For treatment of pyometra (chronic endometritis) in cattle\n• For abortion in beef cows, beef heifers and replacement dairy heifers\n• For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows\n• For use with EAZI-BREED™ CIDR® (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in lactating dairy cows\n• For use with EAZI-BREED™ CIDR® (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers",{"id":224,"kind":185,"statement":225,"species":10,"limitation":10,"source_label":69},20104,"For use with EAZI-BREED™ CIDR® (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers",{"id":227,"kind":185,"statement":228,"species":91,"limitation":10,"source_label":69},20105,"For use with FACTREL® (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows",{"id":230,"kind":185,"statement":231,"species":91,"limitation":10,"source_label":69},20106,"For use with EAZI-BREED™ CIDR® (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in lactating dairy cows",{"id":233,"kind":185,"statement":234,"species":91,"limitation":10,"source_label":69},20107,"For unobserved (silent) estrus in lactating dairy cows with a corpus luteum",{"id":236,"kind":185,"statement":198,"species":101,"limitation":103,"source_label":104},20108,{"id":238,"kind":185,"statement":239,"species":111,"limitation":10,"source_label":69},20109,"For parturition induction in swine",{"id":241,"kind":185,"statement":242,"species":115,"limitation":10,"source_label":69},20110,"For controlling the timing of estrus in estrous cycling mares.\nFor difficult-to-breed mares (clinically anestrous mares that have a corpus luteum).",{"id":244,"kind":185,"statement":245,"species":118,"limitation":119,"source_label":104},20111,"For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers.",{"id":247,"kind":185,"statement":186,"species":123,"limitation":124,"source_label":104},20112,{"id":249,"kind":185,"statement":201,"species":123,"limitation":128,"source_label":104},20113,{"id":251,"kind":185,"statement":252,"species":131,"limitation":253,"source_label":104},20114,"For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows.","Administer 2 to 4 mL FACTREL Injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework:Administer the first dose of FACTREL Injection (2 – 4 mL) at Day 0Administer a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection 6 – 8 days after the first dose of FACTREL Injection.Administer a second dose of FACTREL Injection (2 – 4 mL) 30 to 72 hours after LUTALYSE HighCon InjectionPerform FTAI 0 to 24 hours after the second dose of FACTREL Injection, or inseminate cows on detected estrus using standard herd practices.Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, or persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and\u002For bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water.",{"id":255,"kind":185,"statement":256,"species":131,"limitation":132,"source_label":104},20115,"For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in lactating dairy cows.",{"id":258,"kind":185,"statement":195,"species":131,"limitation":259,"source_label":104},20116,"Breed cows as they are detected in estrus. If estrus has not been observed by 80 hours after injection, breed at 80 hours. If the cow returns to estrus, breed at the usual time relative to estrus. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and\u002For bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water.",{"id":261,"kind":262,"statement":263,"species":10,"limitation":10,"source_label":81},20117,"warning","WARNINGS AND PRECAUTIONS\nUser Safety: Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and\u002For bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water.\nContact Information: To report adverse reactions call Bimeda, Inc. at 1-888-524-6332.\nResidue Warnings: No milk discard or preslaughter drug withdrawal period is required for labeled uses in cattle. No preslaughter drug withdrawal period is required for labeled uses in swine. Use of this product in excess of the approved dose may result in drug residues. Do not use in horses intended for human consumption.\nAnimal Safety Warnings: Severe localized clostridial infections associated with injection of ProstaMate have been reported. In rare instances, such infections have resulted in death.\nAggressive antibiotic therapy should be employed at the first sign of infection at the injection site whether localized or diffuse. Do not administer intravenously (IV) as this route may potentiate adverse reactions. Non-steroidal anti-inflammatory drugs may inhibit prostaglandin synthesis; therefore this class of drugs should not be administered concurrently. Do not administer to pregnant cattle, unless abortion is desired. Cattle administered a progestin would be expected to have a reduced response to ProstaMate. Do not administer to sows and\u002For gilts prior to 3 days of normal predicted farrowing as an increased number of stillbirths and postnatal mortality may result. In mares, ProstaMate is ineffective when administered prior to day-5 after ovulation.\nMare pregnancy status should be determined prior to treatment since dinoprost tromethamine injection has been reported to induce abortion and parturition when sufficient doses were administered. Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract.",{"id":265,"kind":262,"statement":266,"species":10,"limitation":10,"source_label":69},20118,"User Safety: Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and\u002For bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water.\nResidue Warnings: No milk discard or preslaughter drug withdrawal period is required for labeled uses in cattle. No preslaughter drug withdrawal period is required for labeled uses in swine. Use of this product in excess of the approved dose may result in drug residues. Do not use in horses intended for human consumption.\nAnimal Safety Warnings: Severe localized clostridial infections associated with injection of LUTALYSE Injection have been reported. In rare instances, such infections have resulted in death.\nAggressive antibiotic therapy should be employed at the first sign of infection at the injection site whether localized or diffuse. Do not administer intravenously (IV) as this route may potentiate adverse reactions. Non-steroidal anti-inflammatory drugs may inhibit prostaglandin synthesis; therefore this class of drugs should not be administered concurrently. Do not administer to pregnant cattle, unless abortion is desired. Cattle administered a progestin would be expected to have a reduced response to LUTALYSE Injection. Do not administer to sows and\u002For gilts prior to 3 days of normal predicted farrowing as an increased number of stillbirths and postnatal mortality may result. In mares, LUTALYSE Injection is ineffective when administered prior to day-5 after ovulation.\nMare pregnancy status should be determined prior to treatment since LUTALYSE Injection has been reported to induce abortion and parturition when sufficient doses were administered. Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract.",{"id":268,"kind":262,"statement":269,"species":10,"limitation":10,"source_label":77},20119,"User Safety: Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and\u002For bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water.\nResidue Warnings: No milk discard or preslaughter drug withdrawal period is required for labeled uses in cattle. Use of this product in excess of the approved dose may result in drug residues.\nAnimal Safety Warnings: Severe localized clostridial infections associated with injection of LUTALYSE Injection have been reported. In rare instances, such infections have resulted in death. Aggressive antibiotic therapy should be employed at the first sign of infection at the injection site whether localized or diffuse. Do not administer intravenously (IV) as this route may potentiate adverse reactions. Nonsteroidal anti-inflammatory drugs may inhibit prostaglandin synthesis; therefore this class of drugs should not be administered concurrently. Do not administer to pregnant cattle, unless abortion is desired. Cattle administered a progestin would be expected to have a reduced response to LUTALYSE Injection.",{"id":271,"kind":272,"statement":273,"species":10,"limitation":10,"source_label":81},20120,"adverse_reaction","ADVERSE REACTIONS\nCattle: Limited salivation has been reported in some instances.\nSwine: The most frequently observed side effects were erythema and pruritus, slight incoordination, nesting behavior, itching, urination, defecation, abdominal muscle spasms, tail movements, hyperpnea or dyspnea, increased vocalization, salivation, and at the 100 mg (10x) dose only, possible vomiting. These side effects are transitory, lasting from 10 minutes to 3 hours, and were not detrimental to the health of the animal.\nMares: The most frequently observed side effects are sweating and decreased rectal temperature. However, these have been transient in all cases observed and have not been detrimental to the animal.\nOther reactions seen have been increase in heart rate, increase in respiration rate, some abdominal discomfort, locomotor incoordination, and lying down. These effects are usually seen within 15 minutes of injection and disappear within one hour. Mares usually continue to eat during the period of expression of side effects. One anaphylactic reaction of several hundred mares treated with dinoprost tromethamine injection was reported but was not confirmed.\nCONTACT INFORMATIONTo report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS) contact Bimeda, Inc. at 1-888-524-3222. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov\u002Freportanimalae.",{"id":275,"kind":272,"statement":276,"species":10,"limitation":10,"source_label":69},20121,"Cattle: Limited salivation has been reported in some instances.\nSwine: The most frequently observed side effects were erythema and pruritus, slight incoordination, nesting behavior, itching, urination, defecation, abdominal muscle spasms, tail movements, hyperpnea or dyspnea, increased vocalization, salivation, and at the 100 mg (10x) dose only, possible vomiting. These side effects are transitory, lasting from 10 minutes to 3 hours, and were not detrimental to the health of the animal.\nMares: The most frequently observed side effects are sweating and decreased rectal temperature. However, these have been transient in all cases observed and have not been detrimental to the animal.\nOther reactions seen have been increase in heart rate, increase in respiration rate, some abdominal discomfort, locomotor incoordination, and lying down. These effects are usually seen within 15 minutes of injection and disappear within one hour. Mares usually continue to eat during the period of expression of side effects. One anaphylactic reaction of several hundred mares treated with LUTALYSE Injection was reported but was not confirmed.\nCONTACT INFORMATION\nFor a copy of the Safety Data Sheet or to report adverse reactions, call Zoetis Inc. at 1-888-963-8471. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov\u002Freportanimalae.",{"id":278,"kind":279,"statement":280,"species":10,"limitation":10,"source_label":77},20122,"mechanism_of_action","General Biologic Activity: Prostaglandins occur in nearly all mammalian tissues. Prostaglandins, especially PGE’s and PGF’s, have been shown, in certain species, to 1) increase at time of parturition in amniotic fluid, maternal placenta, myometrium, and blood, 2) stimulate myometrial activity, and 3) to induce either abortion or parturition. Prostaglandins, especially PGF2α, have been shown to 1) increase in the uterus and blood to levels similar to levels achieved by exogenous administration which elicited luteolysis, 2) be capable of crossing from the uterine vein to the ovarian artery (sheep), 3) be related to IUD induced luteal regression (sheep), and 4) be capable of regressing the corpus luteum of most mammalian species studied to date. Prostaglandins have been reported to result in release of pituitary tropic hormones. Data suggest prostaglandins, especially PGE’s and PGF’s, may be involved in the process of ovulation and gamete transport. Also PGF2α has been reported to cause increase in blood pressure, bronchoconstriction, and smooth muscle stimulation in certain species.\nMetabolism: A number of metabolism studies have been done in laboratory animals. The metabolism of tritium labeled dinoprost (3H PGF2 alpha) in the rat and in the monkey was similar. Although quantitative differences were observed, qualitatively similar metabolites were produced. A study demonstrated that equimolar doses of 3H PGF2 alpha Tham and 3H PGF2 alpha free acid administered intravenously to rats demonstrated no significant differences in blood concentration of dinoprost. An interesting observation in the above study was that the radioactive dose of 3H PGF2 alpha rapidly distributed in tissues and dissipated in tissues with almost the same curve as it did in the serum. The half-life of dinoprost in bovine blood has been reported to be on the order of minutes. A complete study on the distribution of decline of 3H PGF2 alpha Tham in the tissue of rats was well correlated with thework done in the cow. Cattle serum collected during 24 hours after doses of 0 to 250 mg dinoprost have been assayed by RIA for dinoprost and the 15-keto metabolites. These data support previous reports that dinoprost has a half-life of minutes. Dinoprost is a natural prostaglandin. All systems associated with dinoprost metabolism exist in the body; therefore, no new metabolic, transport, excretory, binding or other systems need be established by the body to metabolize injected dinoprost.\nRelative Bioavailability Study: The requirement for substantial evidence of effectiveness was fulfilled by a pharmacokinetic study comparing the relative bioavailability of the subcutaneous (SC) administration of 25 mg of LUTALYSE HighCon Injection (12.5 mg dinoprost\u002FmL) to the approved intramuscular (IM) administration of 25 mg of LUTALYSE Injection (5 mg dinoprost\u002FmL). The effectiveness data for LUTALYSE Injection at doses of 25 and 35 mg IM were used to support an adjusted Test\u002FReference (T\u002FR) ratio of 1.4 and 90% Confidence Intervals of 80 - 164% for Cmax and AUC to demonstrate therapeutic equivalence.\nThe pivotal relative bioavailability study was a randomized, non-replicated, three treatment, three period, six sequence crossover study in 24 cows (4 cows per sequence). Each cow received a single dose of 25 mg dinoprost administered as 5 mL of LUTALYSE Injection IM, 5 mL of LUTALYSE Injection SC, or 2 mL of LUTALYSE HighCon SC, with a washout period of 48 hours between doses. Plasma samples were collected at 60 and 10 minutes prior to dose administration, and at 5, 10, 15, 20, 30, 75 minutes, and at 2, 3, 4.5, 6, 7.5, and 12 hours after each dose. Samples were analyzed by UPLC-MS\u002FMS for PGF2α (dinoprost) and PGFm (metabolite) concentrations. PGFm was chosen as the analyte of interest because its concentrations are reflective of exogenously administered dinoprost (after subtraction of endogenous concentrations), and it has a longer half-life and therefore less blood level fluctuations than PGF2α. The results of the relative bioavailability study are summarized in Table 1. The Cmax and AUClast of LUTALYSE HighCon were within the adjusted 90% Confidence Intervals. Therefore, the SC administration of 25 mg of LUTALYSE HighCon was equivalent to the IM administration of 25 mg LUTALYSE Injection.\nTable 1: Relative Bioavailability Results for LUTALYSE HighCon Injection\nParameter\nProduct\u002F\nRoute\nLSMean\nRatio\nT\u002F\nR†\nLower\n90% CI\nUpper\n90% CI\nCmax\n(ng\u002FmL)\nLUTALYSE\nInjection\n(IM)*\n41.26\nLUTALYSE\nInjection\n(SC)*\n50.80\n1.23\n110.99\n136.60\nLUTALYSE\nHighCon\nInjection\n(SC)\n55.12\n1.34\n120.42\n148.20\nAUClast) (hr*ng\u002FmL)\nLUTALYSE\nInjection\n(IM)*\n66.85\nLUTALYSE\nInjection\n(SC)\n67.25\n1.00\n96.26\n105.12\nLUTALYSE\nHighCon Injection\n(SC)\n65.81\n0.98\n94.20\n102.87\nCmax - maximum plasma concentration\nAUClast - the area under the plasma concentration vs. time curve from time of injection to the limit of quantification of the assay\n* Reference product and route of administration\n† Geometric means",{"id":282,"kind":279,"statement":283,"species":10,"limitation":10,"source_label":81},20123,"CLINICAL PHARMACOLOGY\nGeneral Biologic Activity: Prostaglandins occur in nearly all mammalian tissues. Prostaglandins, especially PGE’s and PGF’s, have been shown, in certain species, to 1) increase at time of parturition in amniotic fluid, maternal placenta, myometrium, and blood, 2) stimulate myometrial activity, and 3) to induce either abortion or parturition. Prostaglandins, especially PGF2α, have been shown to 1) increase in the uterus and blood to levels similar to levels achieved by exogenous administration which elicited luteolysis, 2) be capable of crossing from the uterine vein to the ovarian artery (sheep), 3) be related to IUD induced luteal regression (sheep), and 4) be capable of regressing the corpus luteum of most mammalian species studied to date. Prostaglandins have been reported to result in release of pituitary tropic hormones. Data suggest prostaglandins, especially PGE’s and PGF’s, may be involved in the process of ovulation and gamete transport. Also PGF2α has been reported to cause increase in blood pressure, bronchoconstriction, and smooth muscle stimulation in certain species.\nMetabolism: A number of metabolism studies have been done in laboratory animals. The metabolism of tritium labeled dinoprost (3H PGF2 alpha) in the rat and in the monkey was similar.\nAlthough quantitative differences were observed, qualitatively similar metabolites were produced. A study demonstrated that equimolar doses of 3H PGF2 alpha Tham and 3H PGF2 alpha free acid administered intravenously to rats demonstrated no significant differences in blood concentration of dinoprost. An interesting observation in the above study was that the radioactive dose of 3H PGF2 alpha rapidly distributed in tissues and dissipated in tissues with almost the same curve as it did in the serum. The half-life of dinoprost in bovine blood has been reported to be on the order of minutes. A complete study on the distribution of decline of 3H PGF2 alpha Tham in the tissue of rats was well correlated with the work done in the cow. Cattle serum collected during 24 hours after doses of 0 to 250 mg dinoprost have been assayed by RIA for dinoprost and the 15-keto metabolites. These data support previous reports that dinoprost has a halflife of minutes. Dinoprost is a natural prostaglandin. All systems associated with dinoprost metabolism exist in the body; therefore, no new metabolic, transport, excretory, binding or other systems need be established by the body to metabolize injected dinoprost.",[285],{"id":286,"documentId":287,"slug":288,"name":289},1002,"i4lsi2qq6bkxo2hsccutdaac","prostaglandins","Prostaglandins",[],[292,297],{"id":293,"documentId":294,"slug":295,"title":296},117,"zkepjdfc0nn3sk1001mw9024","pyometra","Pyometra",{"id":298,"documentId":299,"slug":300,"title":301},130,"uuncwnduwpl74ffi4sz3o14n","endometritis","Endometritis",[]]