[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f4sadahekctyb":5},{"data":4},[],{"data":6,"error":10},{"id":7,"documentId":8,"slug":9,"name":9,"proprietary_name":10,"non_proprietary_name":10,"is_proprietary":10,"active_ingredient":10,"administration_route":10,"available_strength":10,"dosage_form":10,"dose_schedule":10,"drug_unit":10,"is_available_generically":10,"mechanism_of_action":10,"overdosage":10,"warning":10,"species":11,"citations":12,"dose_schedules":27,"available_strengths":39,"label_statements":44,"drug_classes":64,"specialties":70,"medical_conditions":71,"animal_species":72},1860,"pvjs3chhbs000wkgrt8xxkpb","esafoxolaner",null,[],[13,19,23],{"source":14,"licence":15,"source_url":16,"harvested_by":17,"retrieved_at":18},"EMA centrally authorised medicines","EMA reuse with attribution","https:\u002F\u002Fwww.ema.europa.eu\u002Fen\u002Fdocuments\u002Freport\u002Fmedicines-output-medicines-report_en.xlsx","load-reference-corpus.cjs","2026-09-07",{"source":20,"licence":21,"source_url":22,"harvested_by":17,"retrieved_at":18},"FDA Green Book","US public domain","https:\u002F\u002Fanimaldrugsatfda.fda.gov\u002Fadafda\u002Fapp\u002Fsearch\u002Fpublic\u002FingredientsInformationExcel\u002FSection2ActiveIngredients",{"source":24,"licence":25,"source_url":26,"harvested_by":17,"retrieved_at":18},"UK VMD PID","OGL v3.0","https:\u002F\u002Fwww.vmd.defra.gov.uk\u002Fproductinformationdatabase\u002Fdownloads\u002Fvmd_productinformationdatabase.xlsx",[28,34],{"id":29,"dose_text":30,"species":31,"administration_route":32,"limitation":10,"source_label":33},13727,"Administer the entire contents of a provided unit applicator topically once a month at a minimum dose of 0.055 mL\u002Flb (0.12 mL\u002Fkg), which delivers a minimum dose of 0.65 mg\u002Flb (1.44 mg\u002Fkg) esafoxolaner, 0.22 mg\u002Flb (0.48 mg\u002Fkg) eprinomectin, and 4.53 mg\u002Flb (9.98 mg\u002Fkg) praziquantel.","Cats","Topical","NexGard® COMBO",{"id":35,"dose_text":36,"species":10,"administration_route":37,"limitation":10,"source_label":38},13728,"NexGard® COMBO is dosed at a minimum of 0.055 mL\u002Flb (0.12 mL\u002Fkg), which delivers a minimum dose of 0.65 mg\u002Flb (1.44 mg\u002Fkg) esafoxolaner, 0.22 mg\u002Flb (0.48 mg\u002Fkg) eprinomectin, and 4.53 mg\u002Flb (9.98 mg\u002Fkg) praziquantel.\nFor heartworm disease prevention, apply once monthly for at least three months after last exposure to mosquitoes (see Effectiveness).\nAdminister the entire contents of a NexGard® COMBO unit applicator topically once a month as specified in the following table:\nDosing Schedule\nCat Weight (lb)\nVolume (mL)\nEsafoxolaner (mg)\nEprinomectin (mg)\nPraziquantel (mg)\n1.8- 5.5\n0.3\n3.6\n1.2\n24.9\n5.6-16.5\n0.9\n10.8\n3.6\n74.7\n16.6-22\n0.3 + 0.9\n14.4\n4.8\n99.6\n22.1-33\n0.9 + 0.9\n21.6\n7.2\n149.4\nA veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying NexGard® COMBO topically to cats and kittens prior to first use.\nKeep product in original packaging until ready to use.\n1.Use scissors to cut the blister along the dotted line.\n2.Then pull the lid away.\n3.Remove the applicator from the package and hold it upright. Pull back the plunger slightly.\n4.Twist and pull off the cap.\n5.Part the hair on the midline of the neck, between the base of the skull and the shoulder blades until the skin is visible. Place the tip of the applicator on the skin and apply the entire contents directly onto the skin in one spot. The product should be applied to dry skin on an area where the cat cannot lick it off. If the weight of the cat requires a second application, apply the contents in the same manner as described above in the same location.\n6.Wash hands after use with soap and water.\nHeartworm Prevention:\nFor the prevention of heartworm disease, NexGard® COMBO should be administered once a month year-round. At a minimum, administration of NexGard® COMBO should start at least 1 month before the cat’s first expected exposure to mosquitoes and monthly thereafter until at least 3 months after the cat’s last seasonal exposure to mosquitoes (see Effectiveness). If a dose is missed and a 30-day interval between doses is exceeded, administer NexGard® COMBO immediately and resume the monthly dosing schedule. Treatment with fewer than 3 monthly doses may not provide complete heartworm prevention. When replacing another monthly heartworm preventive product in a heartworm prevention program, the first treatment with NexGard® COMBO should be given within one month of the last dose of the former medication. At the discretion of the veterinarian, cats older than 6 months of age may be tested to determine the presence of existing heartworm infection before treatment with NexGard® COMBO. Cats already infected with adult heartworms can be given NexGard® COMBO monthly to prevent further infections.\nFlea Treatment and Prevention:\nFor the treatment and prevention of flea infestations, the use of NexGard® COMBO may begin at any time of year. NexGard® COMBO should be administered year-round at monthly intervals or begin at least one month before fleas become active. However, an environmental infestation may persist for a short time after beginning treatment with NexGard® COMBO because of the development of adult fleas from eggs that were laid prior to the initiation of treatment.\nTick Treatment and Control:\nFor the treatment and control of infestations with Ixodes scapularis and Amblyomma americanum, the use of NexGard® COMBO may begin at any time of year. NexGard® COMBO should be administered year-round at monthly intervals or begin at least one month before the ticks become active.\nTreatment and Control of Roundworms, Hookworms, and Tapeworms:\nNexGard® COMBO provides treatment and control of roundworms (adult and fourth stage larval Toxocara cati), hookworms (adult and fourth stage larval Ancylostoma tubaeforme; adult Ancylostoma braziliense), and tapeworms (Dipylidium caninum). For the treatment of hookworm, roundworms and tapeworm infections, NexGard® COMBO should be administered once as a single dose. Monthly use of NexGard® COMBO will control any subsequent infections. Cats may be exposed to and can become infected with roundworms, hookworms, and tapeworms throughout the year, regardless of season or climate.","TOPICAL","NexGard® COMBO (esafoxalaner, eprinomectin, and praziquantel topical solution)",[40],{"id":41,"strength_text":42,"dosage_form":43,"proprietary_name":33,"species":31,"source_label":33},11930,"Each mL of topical solution contains 12 mg esafoxolaner, 4 mg eprinomectin, and 83 mg praziquantel.","Topical Solution",[45,49,52,56,60],{"id":46,"kind":47,"statement":48,"species":31,"limitation":10,"source_label":33},20130,"indication","For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (fourth stage larval and adult Toxocara cati), hookworm (fourth stage larval and adult Ancylostoma tubaeforme; adult Ancylostoma braziliense), and tapeworm (Dipylidium caninum) infections. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations and the treatment and control of Ixodes scapularis (black-legged tick) and Amblyomma americanum (lone star tick) infestations for one month in cats and kittens 8 weeks of age and older, and weighing 1.8 lbs or greater.",{"id":50,"kind":47,"statement":51,"species":10,"limitation":10,"source_label":38},20131,"NexGard® COMBO is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (fourth stage larval and adult Toxocara cati), hookworm (fourth stage larval and adult Ancylostoma tubaeforme; adult Ancylostoma\nbraziliense), and tapeworm (Dipylidium caninum) infections. NexGard® COMBO kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations and the treatment and control of Ixodes scapularis (black-legged tick) and Amblyomma americanum (lone star tick) infestations for one month in cats and kittens 8 weeks of age and older, and weighing 1.8 lbs or greater.",{"id":53,"kind":54,"statement":55,"species":10,"limitation":10,"source_label":38},20132,"contraindication","There are no known contraindications for the use of NexGard® COMBO.",{"id":57,"kind":58,"statement":59,"species":10,"limitation":10,"source_label":38},20133,"warning","Not for human use. Keep this and all drugs out of sight and reach of children.\nAvoid direct contact with application site for 4 hours or until visibly dry.\nThis product may act as a mild to moderate eye irritant.\nKeep product in the original packaging until use. Wash hands after product administration. If the product accidentally gets into the eyes, rinse thoroughly with water. If wearing contact lenses, flush the eyes first with water and then remove the lenses and continue to flush thoroughly with water. In case of accidental ingestion, or if skin or eye irritation occurs, contact a poison control center or physician for treatment advice.",{"id":61,"kind":62,"statement":63,"species":10,"limitation":10,"source_label":38},20134,"adverse_reaction","In a field safety and effectiveness study, which included a total of 201 households and 380 treated cats (244 cats treated with NexGard® COMBO, 136 cats treated with an active control), the safety of NexGard® COMBO was evaluated over a 90-day period through in-clinic physical examinations or through reporting of abnormalities by the owner. The most frequently reported reactions in the NexGard® COMBO and active control groups are presented in the following table.\nAdverse Reactions by Treatment Group\nEVENT\nTreatment Group\nNEXGARD® COMBO\nActive Control\nn1\n% (n=244)\nn2\n% (n=136)\nVomiting\n16\n6.56\n8\n5.88\nApplication Site Hair Change\n9\n3.69\n0\n0.00\nAnorexia\n7\n2.87\n4\n2.94\nLethargy\n6\n2.46\n5\n3.68\nBacterial skin infection\n4\n1.64\n1\n0.74\nItching\n4\n1.64\n0\n0.00\nSneezing\n4\n1.64\n5\n3.68\nSkin Peeling\n3\n1.23\n2\n1.47\nDiarrhea\n3\n1.23\n3\n2.21\nEpiphora\n3\n1.23\n1\n0.74\nHypersalivation\n3\n1.23\n0\n0.00\nHyperthermia\n3\n1.23\n0\n0.00\nAlopecia\n2\n0.82\n0\n0.00\nDermal thickening\n2\n0.82\n0\n0.00\nEar Pruritus\n2\n0.82\n1\n0.74\nApplication Site Redness\n2\n0.82\n0\n0.00\nConjunctivitis\n1\n0.41\n1\n0.74\n1Number of cats treated with NexGard® COMBO with the identified abnormality.\n2Number of cats treated with Active Control with the identified abnormality.",[65],{"id":66,"documentId":67,"slug":68,"name":69},977,"dyh598dyyrrkm8qulct4upn1","antiparasitic-products-insecticides-and-repellents","Antiparasitic products, insecticides and repellents",[],[],[]]