[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f2u3r0t8vr1no5":5},{"data":4},[],{"data":6,"error":10},{"id":7,"documentId":8,"slug":9,"name":9,"proprietary_name":10,"non_proprietary_name":10,"is_proprietary":10,"active_ingredient":10,"administration_route":10,"available_strength":10,"dosage_form":10,"dose_schedule":10,"drug_unit":10,"is_available_generically":10,"mechanism_of_action":10,"overdosage":10,"warning":10,"species":11,"citations":12,"dose_schedules":27,"available_strengths":396,"label_statements":635,"drug_classes":1036,"specialties":1037,"medical_conditions":1038,"animal_species":1039},1787,"klur8ugr2hps8urff0xqazx4","pyrantel",null,[],[13,19,23],{"source":14,"licence":15,"source_url":16,"harvested_by":17,"retrieved_at":18},"EMA centrally authorised medicines","EMA reuse with attribution","https:\u002F\u002Fwww.ema.europa.eu\u002Fen\u002Fdocuments\u002Freport\u002Fmedicines-output-medicines-report_en.xlsx","load-reference-corpus.cjs","2026-09-07",{"source":20,"licence":21,"source_url":22,"harvested_by":17,"retrieved_at":18},"FDA Green Book","US public domain","https:\u002F\u002Fanimaldrugsatfda.fda.gov\u002Fadafda\u002Fapp\u002Fsearch\u002Fpublic\u002FingredientsInformationExcel\u002FSection2ActiveIngredients",{"source":24,"licence":25,"source_url":26,"harvested_by":17,"retrieved_at":18},"UK VMD PID","OGL v3.0","https:\u002F\u002Fwww.vmd.defra.gov.uk\u002Fproductinformationdatabase\u002Fdownloads\u002Fvmd_productinformationdatabase.xlsx",[28,34,39,44,50,56,61,66,72,77,81,86,91,95,99,103,108,113,119,122,128,132,136,140,145,150,155,160,164,169,174,179,184,186,190,195,200,204,210,214,218,222,226,230,234,238,242,246,251,254,260,265,270,274,277,281,285,289,293,297,300,303,307,311,315,319,323,327,331,334,338,341,345,350,354,357,361,365,369,372,376,380,384,388,392],{"id":29,"dose_text":30,"species":31,"administration_route":32,"limitation":10,"source_label":33},12931,"PyrantelCare™ (pyrantel tartrate) Type A Medicated Article is to be administered on a continuous basis either as a top-dress or mixed in the horse’s daily grain ration at the rate of 1.2 mg\u002Flb (2.64 mg\u002Fkg) of body weight daily. The duration of administration is for the period during which the horse is at risk of exposure to internal parasites. Foals may be treated at such time when consistent intake of grain mix is occurring. This is generally between 2 to 3 months of age. PyrantelCare™ (pyrantel tartrate) Type A Medicated Article may be used in mares at any stage of pregnancy or lactation. Stallion fertility is not affected by the use of PyrantelCare™ (pyrantel tartrate) Type A Medicated Article.","Horses","Oral","PyrantelCare®",{"id":35,"dose_text":36,"species":31,"administration_route":32,"limitation":37,"source_label":38},12932,"It is administered as a single dose at 12.5 milligrams of pyrantel tartrate per 2.2 pounds of body weight mixed with the usual grain ration.","It is recommended that severely debilitated animals not be treated with this drug. Do not use in horses intended for food.","Strongid®",{"id":40,"dose_text":41,"species":31,"administration_route":32,"limitation":42,"source_label":43},12933,"1.2 milligrams per pound (2.64 milligrams per kilogram) of body weight.","Administer either as a top-dress (not to exceed 20,000 grams per ton) or mixed in the horse's daily grain ration (not to exceed 1,200 grams per ton) during the time that the animal is at risk of exposure to internal parasites. Not for use in horses intended for food. Consult your veterinarian before using in severely debilitated animals and for assistance in the diagnosis, treatment, and control of parasitism. Consult veterinarian before using in severely debilitated animals. Do not mix in Type B or Type C medicated feeds containing bentonite.","Continuex™",{"id":45,"dose_text":46,"species":47,"administration_route":32,"limitation":48,"source_label":49},12934,"Equivalent of 3 milligrams pyrantel base per pound of body weight.","Horses (ponies)","Administered as a single dose mixed with the usual grain ration, or by stomach tube, or by dose syringe. Not for use in horses and ponies to be slaughtered for food purposes. When the drug is for administration by stomach tube, it shall be labeled: \"Federal law restricts this drug to use by or on the order of a licensed veterinarian.” When the drug is not for administration by stomach tube, it shall be labeled: “Consult your veterinarian for in the diagnosis, control, and treatment of parasitism.”","Anthelban V",{"id":51,"dose_text":52,"species":53,"administration_route":32,"limitation":54,"source_label":55},12935,"Administer in the animal's feed bowl as a single dose by itself or mixed in a small quantity of food.","Dogs (and puppies)","Additional treatment may be required and should be confirmed by examination within 2 to 4 weeks. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.","Evict®",{"id":57,"dose_text":58,"species":53,"administration_route":32,"limitation":59,"source_label":60},12936,"Equivalent of 2.27 milligrams of pyrantel base per pound of body weight.","Administer in the animal's feed bowl as a single dose by itself or mixed in a small quantity of food. Additional treatment may be required and should be confirmed by examination within 2 to 4 weeks. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.","Pyrantel Pamoate Suspension",{"id":62,"dose_text":63,"species":64,"administration_route":32,"limitation":65,"source_label":60},12937,"Equivalent to 2.27 milligrams of pyrantel base per pound of body weight.","Dogs (puppies, adults, and in lactating bitches after whelping)","Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.",{"id":67,"dose_text":68,"species":69,"administration_route":32,"limitation":70,"source_label":71},12938,"Administer orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg\u002Flb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg\u002Flb), and 5 mg of praziquantel per kg (2.27 mg\u002Flb) of body weight, as follows:\n6.0 to 12 pounds- one tablet containing 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel\n12.1 to 25 pounds- one tablet containing 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel\n25.1 to 50 pounds- one tablet containing 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel\n50.1 to 100 one tablet containing 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel","Dogs","Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.","IVERHART MAX® Chew",{"id":73,"dose_text":74,"species":69,"administration_route":32,"limitation":75,"source_label":76},12939,"A minimum of 6 micrograms of ivermectin and 5 milligrams of pyrantel (as pamoate salt) per kilogram (2.72 micrograms and 2.27 milligrams per pound) of body weight.\nup to 25 pounds: 68 micrograms ivermectin and 57 milligrams pyrantel pamoate\n26 to 50 pounds: 136 micrograms ivermectin and 114 milligrams pyrantel pamoate\n51 to 100 pounds: 272 micrograms ivermectin and 227 milligrams pyrantel pamoate","Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian.","Tri-Heart Plus Chewable Tablets",{"id":78,"dose_text":79,"species":69,"administration_route":32,"limitation":10,"source_label":80},12940,"Administer orally once a month at the minimum dose of 1.14 mg\u002Flb (2.5 mg\u002Fkg) afoxolaner, 5.45 mcg\u002Flb (12 mcg\u002Fkg) moxidectin, and 2.27 mg\u002Flb (5.0 mg\u002Fkg) pyrantel (as pamoate salt). For heartworm disease prevention, give once monthly for at least six months after last exposure to mosquitoes.","NexGard® PLUS",{"id":82,"dose_text":83,"species":69,"administration_route":32,"limitation":84,"source_label":85},12941,"Provides at least 2.27 milligrams of pyrantel base per pound of body weight for dogs weighing more than 5 pounds, and at least 4.54 milligrams of pyrantel base per pound body weight for dogs weighing 5 pounds or less.","Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Retreatment of adult dogs may be necessary at monthly intervals as determined by laboratory fecal examination. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.","Pyrantel Pamoate Chewable Tablets",{"id":87,"dose_text":88,"species":69,"administration_route":32,"limitation":89,"source_label":90},12942,"For dogs weighing over 5 pounds, use at least 2.27 milligrams of pyrantel base per pound of body weight. For dogs weighing 5 pounds or less, use at least 4.54 milligrams of pyrantel base per pound of body weight.","Administer orally directly or in a small amount of food. To prevent reinfection of T. canis in puppies, lactating bitches after whelping, and adult dogs; treat puppies 2, 3, 4, 6, 8, and 10 weeks of age; treat lactating bitches 2 to 3 weeks after whelping; routinely treat adult dogs monthly. Do not withhold food prior to or after treatment. The presence of these parasites should be confirmed by laboratory fecal examination. A followup fecal examination should be conducted 2 to 4 weeks after first treatment regimen to determine the need for re-treatment. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.","Dog Wormer Tablets",{"id":92,"dose_text":93,"species":69,"administration_route":32,"limitation":10,"source_label":94},12943,"Administer orally once a month, at the minimum dosage of 9 mg\u002Flb (20 mg\u002Fkg) lotilaner, 0.009 mg\u002Flb (0.02 mg\u002Fkg) moxidectin, 2.28 mg\u002Flb (5 mg\u002Fkg) praziquantel, and 2.28 mg\u002Flb (5 mg\u002Fkg) pyrantel (as pamoate salt).","Credelio Quattro™",{"id":96,"dose_text":97,"species":69,"administration_route":32,"limitation":10,"source_label":98},12944,"SimparicaTRIO® is given orally, once a month, at the recommended minimum dose of 0.54 mg\u002Flb (1.2 mg\u002Fkg) sarolaner, 0.011 mg\u002Flb (24 µg\u002Fkg) moxidectin, and 2.27 mg\u002Flb (5 mg\u002Fkg) pyrantel (as pamoate salt).","Simparica TRIO®",{"id":100,"dose_text":101,"species":69,"administration_route":32,"limitation":75,"source_label":102},12945,"Administer a minimum of 6 micrograms of ivermectin and 5 mg of pyrantel per kilogram (2.72 micrograms and 2.27 mg per pound) of body weight monthly.","Iverhart™ Plus Flavored Chewables",{"id":104,"dose_text":105,"species":106,"administration_route":32,"limitation":10,"source_label":107},12946,"Administer as single dose by depositing paste on dorsum of the tongue using the dose syringe. Equivalent of 3 milligrams pyrantel base per pound of body weight.","Horses and ponies","Exodus™ Paste",{"id":109,"dose_text":110,"species":106,"administration_route":32,"limitation":111,"source_label":112},12947,"Equivalent of 3 milligrams pyrantel base per pound of body weight","Not for use in horses and ponies to be slaughtered for food purposes.","Primex®",{"id":114,"dose_text":115,"species":116,"administration_route":32,"limitation":117,"source_label":118},12948,"Administer a minimum dose of 5 milligrams\npraziquantel and 5 milligrams pyrantel pamoate per kilogram body weight (2.27 milligrams praziquantel and 2.27 milligrams pyrantel pamoate per pound body weight) according to the dosing tables on labeling.","Dogs (Puppies and Small Dogs 6.0-25 Lbs)","Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.Do not de-worm a dog or puppy that is sick. Consult a veterinarian for diagnosis of the illness. VIRBANTEL® Flavored Chewables are safe for use in puppies 12 weeks or older and adult dogs. Safety in breeding dogs and pregnant bitches has not been tested.","Virbantel®",{"id":120,"dose_text":115,"species":121,"administration_route":32,"limitation":117,"source_label":118},12949,"Dogs (Medium and Large Dogs- Greater than 25 Lbs)",{"id":123,"dose_text":124,"species":125,"administration_route":32,"limitation":126,"source_label":127},12950,"Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg\u002Flb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg\u002Flb) and 5 mg of praziquantel per kg (2.27 mg\u002Flb) of body weight.\n(One table monthly containing 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel)","Dogs (12.1 - 25 Lbs)","For oral use in dogs only.\nIVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets.\nFederal law restricts this drug to use by or on the order of a licensed veterinarian.","IVERHART MAX®",{"id":129,"dose_text":130,"species":131,"administration_route":32,"limitation":126,"source_label":127},12951,"Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg\u002Flb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg\u002Flb) and 5 mg of praziquantel per kg (2.27 mg\u002Flb) of body weight.\n(One tablet monthly containing 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel)","Dogs (6.0 - 12 Lbs)",{"id":133,"dose_text":134,"species":135,"administration_route":32,"limitation":126,"source_label":127},12952,"Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg\u002Flb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg\u002Flb) and 5 mg of praziquantel per kg (2.27 mg\u002Flb) of body weight.\n(One tablet monthly containing 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel)","Dogs (50.1 - 100 Lbs)",{"id":137,"dose_text":138,"species":139,"administration_route":32,"limitation":126,"source_label":127},12953,"Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg\u002Flb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg\u002Flb) and 5 mg of praziquantel per kg (2.27 mg\u002Flb) of body weight.\n(One tablet monthly containing 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel)","Dogs (25.1 - 50 Lbs)",{"id":141,"dose_text":63,"species":142,"administration_route":32,"limitation":143,"source_label":144},12954,"Dogs (puppies, adults, lactating bitches after whelping)","Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism","Liqui-Vict 2X™",{"id":146,"dose_text":147,"species":148,"administration_route":32,"limitation":149,"source_label":55},12955,"Equivalent to 2.27 or 4.54 milligrams of pyrantel base per pound of body weight.","Dogs (adults, puppies, and lactating bitches)","Administer to puppies at 2,3,4,6,8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.\nFor use of 2.27 and 4.54 milligrams per milliliter product. See No. 023851 for use of 4.54 milligrams per milliliter product",{"id":151,"dose_text":152,"species":153,"administration_route":32,"limitation":10,"source_label":154},12956,"200 grams lincomycin (as lincomycin hydrochloride agricultural grade) and 96 grams (0.0106 percent) pyrantel tartrate per ton of Type C medicated feed. Feed as the sole ration for 21 days. Do not\nmix in feeds containing bentonite.","Swine","LINCOMIX® and Banminth®",{"id":156,"dose_text":157,"species":153,"administration_route":32,"limitation":158,"source_label":159},12957,"Pyrantel tartrate at 96 grams (0.0106 percent) per ton of feed plus carbadox at 50 grams (0.0055 percent) per ton of feed.","Do not feed to swine weighing over 75 pounds. Do not feed within 10 weeks of slaughter. Consult a veterinarian before feeding to severely debilitated animals. Feed continuously as sole ration. Do not use in Type C feeds containing less than 15 percent crude protein. Consult veterinarian before using in severely debilitated animals. Do not mix in Type B or Type C medicated feeds containing bentonite.","Banminth® \u002F Mecadox®",{"id":161,"dose_text":162,"species":153,"administration_route":32,"limitation":163,"source_label":154},12958,"40 or 100 grams lincomycin hydrochloride and 800 grams (0.0881 percent) pyrantel tartrate per ton of Type C medicated feed","Feed as a single therapeutic treatment. Feed at a rate of 1 lb of feed per 40 lb of body weight for animals up to 200 lb, and 5 lb of feed per head for animals over 200 lb. Not to be fed to swine that weigh more than 250 pounds. Do not mix in feeds containing bentonite. Occasionally, swine fed lincomycin may within the first two days after the onset of treatment develop diarrhea and\u002For swelling of the anus. On rare occasions, some pigs may show reddening of the skin and irritable behavior. These conditions have been self-correcting within five to eight days without discontinuing the lincomycin treatment. The effects of lincomycin on swine reproductive performance, pregnancy, and lactation have not been determined. Do not allow rabbits, hamsters, guinea pigs, horses, or ruminants access to feeds containing lincomycin. Ingestion by these species may result in severe gastrointestinal effects. Withdraw 24 hours prior to slaughter.",{"id":165,"dose_text":166,"species":153,"administration_route":32,"limitation":167,"source_label":168},12959,"96 grams (0.0106 percent) pyrantel tartrate and 40 or 100 grams tylosin per ton of Type C medicated feed.","Feed 40 or 100 g of tylosin per ton of complete feed continuously as the sole ration for 2 to 6 weeks after treatment with tylosin in drinking water (250 mg tylosin per gallon) for 3 to 10 days. Do not use in any finished feed (supplement, concentrate or complete feed) containing bentonite. Withdraw 24 hours prior to slaughter.","Tylan™ and Banminth®",{"id":170,"dose_text":171,"species":153,"administration_route":32,"limitation":172,"source_label":173},12960,"96 grams (0.0106 percent) grams per ton of feed.","Feed for 3 days as the sole ration in a Type C feed. Withdraw 24 hours prior to slaughter. Consult veterinarian before using in severely debilitated animals. Do not mix in Type B or Type C medicated feeds containing bentonite.","Super Swine Wormer B-9 19.2 Banm.",{"id":175,"dose_text":176,"species":153,"administration_route":32,"limitation":177,"source_label":178},12961,"800 grams (0.0881 percent) per ton of feed.","As sole ration for a single therapeutic treatment in Type C feed. Feed at the rate of 1 pound of feed per 40 pound of body weight for animals up to 200 pounds, and 5 pounds of feed per head for animals 200 pounds or over. Withdraw 24 hours prior to slaughter. Consult veterinarian before using in severely debilitated animals. Do not mix in Type B or Type C medicated feeds containing bentonite.","Ban-D-Wormer II Banminth®",{"id":180,"dose_text":181,"species":153,"administration_route":32,"limitation":182,"source_label":183},12962,"96 grams (0.0106 percent).","Feed continuously as the sole ration in a Type C feed. Withdraw 24 hours prior to slaughter. Consult veterinarian before using in severely debilitated animals. Do not mix in Type B or Type C medicated feeds containing bentonite.","Swine Wormer-BN Banminth®",{"id":185,"dose_text":153,"species":153,"administration_route":32,"limitation":182,"source_label":173},12963,{"id":187,"dose_text":36,"species":188,"administration_route":32,"limitation":37,"source_label":189},12964,"Horses and Ponies","Banminth®",{"id":191,"dose_text":36,"species":192,"administration_route":32,"limitation":193,"source_label":194},12965,"Horses (and ponies)","It is recommended that severely debilitated animals not be treated with this drug. Do not use in horses or colts intended for food.","Purina® Horse & Colt Wormer",{"id":196,"dose_text":46,"species":192,"administration_route":197,"limitation":198,"source_label":199},12966,"Oral, Nasogastric","Administered as a single dose mixed with the usual grain ration, or by stomach tube, or by dose syringe. Not for use in horses and ponies to be slaughtered for food purposes. When the drug is for administration by stomach tube, it shall be labeled: \"Federal law restricts this drug to use by or on the order of a licensed veterinarian.'' When the drug is not for administration by stomach tube, it shall be labeled: ``Consult your veterinarian for in the diagnosis, control, and treatment of parasitism.''","Strongid® T",{"id":201,"dose_text":63,"species":202,"administration_route":32,"limitation":65,"source_label":203},12967,"Dogs (puppies, adult dogs, and lactating bitches after whelping)","Primex® Canine",{"id":205,"dose_text":206,"species":207,"administration_route":32,"limitation":208,"source_label":209},12968,"0.5 Tablet No.1","Dogs: Weighing 2 to 4 pounds (0.9 to 1.8 kilograms)","Do not use in pregnant animals. Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian","Drontal™ Plus",{"id":211,"dose_text":212,"species":213,"administration_route":32,"limitation":208,"source_label":209},12969,"1 tablet No.1","Dogs: Weighing 5 to 7 pounds (2.3 to 3.2 kilograms):",{"id":215,"dose_text":216,"species":217,"administration_route":32,"limitation":208,"source_label":209},12970,"1.5 tablet No.1","Dogs: Weighing 8 to 12 pounds (3.6 to 5.4 kilograms)",{"id":219,"dose_text":220,"species":221,"administration_route":32,"limitation":208,"source_label":209},12971,"2 tablets No.1","Dogs: Weighing 13 to 18 pounds (5.9 to 8.2 kilograms)",{"id":223,"dose_text":224,"species":225,"administration_route":32,"limitation":208,"source_label":209},12972,"2.5 tablets No.1","Dogs: Weighing 19 to 25 pounds (8.6 to 11.4 kilograms)",{"id":227,"dose_text":228,"species":229,"administration_route":32,"limitation":208,"source_label":209},12973,"1 tablet No.2","Dogs: Weighing 26 to 30 pounds (11.8 to 13.6 kilograms)",{"id":231,"dose_text":232,"species":233,"administration_route":32,"limitation":208,"source_label":209},12974,"1.5 tablets No.2","Dogs: Weighing 31 to 44 pounds (14.1 to 20.0 kilograms)",{"id":235,"dose_text":236,"species":237,"administration_route":32,"limitation":208,"source_label":209},12975,"2.0 tablets No.2 or 1.0 Tablet No. 3","Dogs: Weighing 45 to 60 pounds (20.4 to 27.2 kilograms)",{"id":239,"dose_text":240,"species":241,"administration_route":32,"limitation":208,"source_label":209},12976,"1.5 tablets No. 3","Dogs: Weighing 61 to 90 pounds (27.7 to 40.9 kilograms)",{"id":243,"dose_text":244,"species":245,"administration_route":32,"limitation":208,"source_label":209},12977,"2 tablets No. 3","Dogs: Weighing 91 to 120 pounds (41.3 to 54.5 kilograms)",{"id":247,"dose_text":206,"species":248,"administration_route":32,"limitation":249,"source_label":250},12978,"Dogs: Weighing 2 to 4 pounds","Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age.\nFasting is neither necessary nor recommended.\nConsult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.\nConsult your veterinarian before administering the tablets to weak or debilitated animals.\nDo not deworm a dog or puppy that is sick.\nConsult your veterinarian for diagnosis of the illness and appropriate care.","Quad Dewormer",{"id":252,"dose_text":212,"species":253,"administration_route":32,"limitation":249,"source_label":250},12979,"Dogs: Weighing 5 to 7 pounds",{"id":255,"dose_text":256,"species":257,"administration_route":32,"limitation":258,"source_label":259},12980,"Administer a minimum dose of 2.27 mg praziquantel and 9.2 pyrantel pamoate per pound of bodyweight according to the dosing tables on labeling.","Cats and Kittens (Greater Than 2 Months of Age Or At Least 2 Lbs)","May be given directly by mouth or in a small amount of food. Do not withhold food prior to or after treatment. If reinfection occurs, treatment may be repeated. Consult your veterinarian before giving to sick or pregnant animals. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Not for use in kittens less than 2 months of age or weighing less than 2.0 pounds.","Drontal™ Tablets",{"id":261,"dose_text":262,"species":10,"administration_route":263,"limitation":10,"source_label":264},12981,"As a single therapeutic treatment in complete feed; feed at the rate 1 lb of feed per 40 lb of body weight for animals up to 200 lb. For animals 200 lb or over, feed 5 lb of feed per head. Quantity of medicated feed required to treat pigs of various body weight is shown below:\nPig Weight (lb)\n20\n40\n60\n80\n100\n200 and over\nQuantity of Feed per Pig\n1\u002F2 lb\n1 lb\n1 1\u002F2 lb\n2 lb\n2 1\u002F2 lb\n5 lb\nFast pigs overnight for optimum results. Pigs will generally consume this quantity of medicated feed within a few hours time after which regular feeding should be resumed. Better worming is achieved when pigs are separated by size into different lots or pens for treatment. Water should be made available to animals during fasting and treatment periods.\nComplete Swine Feeds Containing 0.0106% (96 g\u002Ft) Pyrantel Tartrate\nAmount of Banminth 48\nper Ton of Complete Feed\nResultant Use Level of Pyrantel Tartrate in Complete Feed\nIndications for Use\nDirections for Use\n2 lb\n0.0106%\n(96 g\u002Ft)\nAid in the prevention of migration and establishment of large roundworm (A. suum) infections; aid in the prevention of establishment of nodular worm (Oesophagostomum) infections in swine.\nFeed continuously as the sole ration\n2 lb\n0.0106%\n(96 g\u002Ft)\nFor the removal and control of large roundworm (Ascaris suum) infections in swine.†\nFeed for 3 days as the sole ration.\nSwine Protein Supplements for Further Dilution to Feed Containing 0.0106% (96 g\u002Ft) Pyrantel Tartrate\nAmount of Banminth 48\nper Ton of Protein Supplement*\nIndications for Use\nDirections\nTo calculate the amount of Banminth 48 per ton of protein supplement, divide 4000 by the quantity (lb) of protein supplement that will be mixed with grain(s) to produce a ton of complete feed, that is:\n4000 ÷ X = lb of Banminth 48 per ton of protein supplement.\nwhere X = quantity (lb) of protein supplement that will be mixed with grain(s) to produce a ton of complete feed.\nExample Calculation: Directions for use of the protein supplement require that 500 lb are to be mixed with grain(s) to produce a ton of complete feed.\n4000 ÷ 500 = 8 lb of Banminth 48 per\nton of protein supplement.\nAid in the prevention of migration and establishment of large roundworm (A. suum)infections; aid in the prevention of establishment of nodular worm (Oesophagostomum) infections in swine.\nPrepare a complete feed by mixing proper quantities of protein supplement with grain(s). If pelleted, grind pellets before or during mixing. The resultant complete feed contains 0.0106% (96 g\u002Ft) pyrantel tartrate and is to be fed continuously as the sole ration.\nFor the removal and control of large roundworm (A. suum) infections in swine.†\nPrepare a complete feed by mixing proper quantities of protein supplement with grain(s). If pelleted, grind pellets before or during mixing. The resultant complete feed contains 0.0106% (96 g\u002Ft) pyrantel tartrate and is to be fed for 3 days as the sole ration.\nSwine Protein Supplements for Further Dilution to Feed Containing 0.0881% (800 g\u002Ft) Pyrantel Tartrate\nAmount of Banminth 48\nper Ton of Protein Supplement*\nIndications for Use\nDirections for Use\nTo calculate the amount of Banminth 48 per ton of protein supplement, divide 33,333 by the quantity (lb) of protein supplement that will be mixed with grain(s) to produce a ton of complete feed, that is:\n33,333 ÷ X = lb of Banminth 48 per ton of protein supplement.\nwhere X = quantity (lb) of protein supplement that will be mixed with grain(s) to produce a ton of complete feed.\nExample Calculation: Directions for use of the protein supplement require that 333 lb are to be mixed with grain(s) to produce a ton of complete feed.\n33,333 ÷ 333 = 100 lb of Banminth 48 per ton of protein supplement.\nFor the removal and control of large roundworm (A. suum)and nodular worm (Oesophagostomum) infections in swine.†\nPrepare a complete feed by mixing the proper quantities of protein supplement with grain(s). If pelleted, grind pellets before or during mixing. The resultant complete feed contains 0.0881% (800 g\u002Ft) pyrantel tartrate and is to be fed as sole ration for a single therapeutic treatment at the rate of 1 lb of feed per 40 lb of body weight for animals up to 200 lb. For animals 200 lb or over, feed 5 lb of feed per head. Fast pigs overnight for optimum results. Pigs will generally consume this quantity of medicated feed within a few hours time, after which regular feeding should be resumed. Better worming is achieved when pigs are separated by size into different lots or pens for treatment. Water should be made available to animals during fasting and treatment periods.\n* To find grams of pyrantel tartrate, multiply lb of Banminth by 48.\n† Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.","ORAL","Banminth®48 (pyrantel tartrate) TYPE A MEDICATED ARTICLE",{"id":266,"dose_text":267,"species":10,"administration_route":268,"limitation":10,"source_label":269},12982,"DOSAGE: IVERHART PLUS® (ivermectin\u002Fpyrantel) Flavored Chewables should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg\u002Flb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg\u002Flb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of roundworms and hookworms is as follows:\nDog Weight\nFlavored Chewable Per Month\nIvermectin Content\nPyrantel Content\nColor Coding on Carton\n0-25 lbs\n1\n68 mcg\n57 mg\nBlue\n26-50 lbs\n1\n136 mcg\n114 mg\nGreen\n51-100 lbs\n1\n272 mcg\n227 mg\nBrown\nIVERHART PLUS Flavored Chewables are recommended for dogs 6 weeks of age and older. For dogs over 100 lbs use the appropriate combination of these flavored chewables.\nADMINISTRATION: Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light.\nBecause most dogs find IVERHART PLUS Flavored Chewables palatable, the product can be ordered to the dog by hand. To avoid the risk of choking or intestinal obstruction, the chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing (see PRECAUTIONS and POST-APPROVAL EXPERIENCE). Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Alternatively, it may be added intact to a small amount of dog food to encourage chewing, but care should be taken to ensure that the dog consumes the complete dose at one time.\nTreated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.\nIVERHART PLUS Flavored Chewables should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dogs first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dogs last exposure to mosquitoes.\nWhen replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of IVERHART PLUS Flavored Chewables must be given within a month (30 days) of the last dose of the former medication.\nIf the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the flavored chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with IVERHART PLUS Flavored Chewables and resumption of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms.\nMonthly treatment with IVERHART PLUS Flavored Chewables also provides effective treatment and control of roundworms (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.","oral","IVERHART PLUS® (ivermectin\u002Fpyrantel) Flavored Chewables",{"id":271,"dose_text":272,"species":10,"administration_route":263,"limitation":10,"source_label":273},12983,"Credelio Quattro\u002FCredelio Quattro-CA1 is given orally at the minimum dosage of 9 mg\u002Flb (20 mg\u002Fkg) lotilaner, 0.009 mg\u002Flb (0.02 mg\u002Fkg) moxidectin, 2.28 mg\u002Flb (5 mg\u002Fkg) praziquantel, and 2.28 mg\u002Flb (5 mg\u002Fkg) pyrantel (as pamoate salt). Credelio Quattro\u002FCredelio Quattro-CA1 must be administered with food (see\nClinical Pharmacology\n). Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If vomiting occurs within an hour after administration, readminister a new dose of Credelio Quattro\u002FCredelio Quattro-CA1.\nCredelio Quattro:\nCredelio Quattro is given once a month. If a dose is missed, give Credelio Quattro immediately and resume a monthly dosing schedule.\nDosing Schedule:\n*As pamoate salt\nBody Weight (lbs)\nTablets to Administer\nLotilaner\nper Tablet (mg)\nMoxidectin\nper Tablet (mg)\nPraziquantel\nper Tablet (mg)\nPyrantel*\nper Tablet (mg)\n3.3 – 6\n1\n56.25\n0.056\n14.25\n14.25\n6.1 – 12\n1\n112.5\n0.113\n28.5\n28.5\n12.1 – 25\n1\n225\n0.225\n57\n57\n25.1 – 50\n1\n450\n0.45\n114\n114\n50.1 – 100\n1\n900\n0.9\n228\n228\n> 100\nAdminister the appropriate combination of tablets\nHeartworm Prevention\nCredelio Quattro should be administered year-round at monthly intervals or at least within 1 month of the animal’s first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog’s last seasonal exposure. If a dose is missed, give Credelio Quattro immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, Credelio Quattro should be given within 1 month of the last dose of the former medication.\nIntestinal Nematode and Cestode Treatment and Control\nCredelio Quattro should be administered as a single dose for the treatment of roundworm, hookworm, and tapeworm infections. Monthly use of Credelio Quattro will control any subsequent infections. Dogs may be exposed to and can become infected with gastrointestinal worms throughout the year, regardless of season or climate. Clients should be advised of appropriate measures to prevent reinfection of their dog with intestinal parasites.\nFlea Treatment and Prevention\nTreatment with Credelio Quattro should be administered year-round at monthly intervals or started at least 1 month before fleas become active. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.\nTick Treatment and Control\nTreatment with Credelio Quattro can begin at any time of the year. Credelio Quattro should be administered year-round at monthly intervals or started at least 1 month before ticks become active.\nCredelio Quattro-CA1:\nNew World Screwworm (NWS) Myiasis Treatment\nA single dose of Credelio Quattro-CA1 is reasonably expected to treat C. hominivorax present at the time of treatment. Re-infestation with C. hominivorax may occur sooner than one month. Treatment should be used in conjunction with the mechanical removal of larvae (live and dead) remaining in the wound after treatment (see\nPRECAUTIONS\n).","Credelio Quattro™ CredelioQuattro™-CA1(lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets)",{"id":275,"dose_text":276,"species":10,"administration_route":263,"limitation":10,"source_label":98},12984,"SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg\u002Flb (1.2 mg\u002Fkg) sarolaner, 0.011 mg\u002Flb (24 μg\u002Fkg) moxidectin, and 2.27 mg\u002Flb (5 mg\u002Fkg) pyrantel (as pamoate salt).\nDosage Schedule\nBody Weight\n(lbs)\nSarolaner per\nTablet\n(mg)\nMoxidectin\nper Tablet\n(mg)\nPyrantel\nper\nTablet\n(mg)\nNumber\nof Tablets\nAdministered\n2.8 to 5.5\n3\n0.06\n12.5\nOne\n5.6 to 11.0\n6\n0.12\n25\nOne\n11.1 to 22.0\n12\n0.24\n50\nOne\n22.1 to 44.0\n24\n0.48\n100\nOne\n44.1 to 88.0\n48\n0.96\n200\nOne\n88.1 to 132.0\n72\n1.44\n300\nOne\n>132.0\nAdminister the appropriate combination of tablets\nSIMPARICA TRIO can be offered to the dog with or without food.\nCare should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing.\nHeartworm Prevention:\nSIMPARICA TRIO should be administered at monthly intervals year‑round or at least within one month of the animal’s first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog’s last seasonal exposure. If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, SIMPARICA TRIO should be given within one month of the last dose of the former medication.\nFlea Treatment and Prevention:\nTreatment with SIMPARICA TRIO may begin at any time of the year. SIMPARICA TRIO should be administered year‑round at monthly intervals or started at least one month before fleas become active.\nTo minimize the likelihood of flea re‑infestation, it is important to treat all dogs and cats within a household with a flea control product.\nTapeworm Prevention:\nTreatment with SIMPARICA TRIO may begin at any time of the year. SIMPARICA TRIO should be administered year-round at monthly intervals or started at least one month before fleas become active.\nSIMPARICA TRIO will only prevent D. caninum infections by killing the fleas on the treated dog. Dogs may also become infected with D. caninum by ingesting fleas from untreated animals, it is therefore recommended that all pets in a household are treated for fleas.\nTick Treatment and Control:\nTreatment with SIMPARICA TRIO can begin at any time of the year. SIMPARICA TRIO should be administered year‑round at monthly intervals or started at least one month before ticks become active.\nIntestinal Nematode Treatment and Control:\nFor the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections, SIMPARICA TRIO should be administered once as a single dose. Monthly use of SIMPARICA TRIO will control any subsequent infections.",{"id":278,"dose_text":279,"species":10,"administration_route":263,"limitation":10,"source_label":280},12985,"DOSAGE: Tri-Heart® Plus should be administered orally at monthly intervals at the\nrecommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg\u002Flb) and 5 mg of pyrantel (as\npamoate salt) per kg (2.27 mg\u002Flb) of body weight. The recommended dosing schedule for prevention of canine\nheartworm disease and for the treatment and control of roundworms and hookworms is as follows:\nDog Weight\nChewable Tablets\nper Month\nIvermectin\nContent\nPyrantel\nContent\nColor Coding on\nBlister Card and Carton\nUp to 25 lbs.\n1\n68 mcg\n57 mg\nBlue\n26 to 50 lbs.\n1\n136 mcg\n114 mg\nGreen\n51 to 100 lbs.\n1\n272 mcg\n227 mg\nBrown\nTri-Heart® Plus is recommended for dogs 6 weeks of\nage and older. For dogs over 100 lbs, use the appropriate combination of these tablets.\nADMINISTRATION: Remove only one chewable tablet at a time from the blister card.\nBecause most dogs find Tri-Heart® Plus palatable, the product can be\noffered to the dog by hand. Alternatively, it may be added intact to a small amount of dry food\nor placed in the back of the dog’s mouth for forced swallowing.\nCare should be taken that the dog consumes the complete dose, and treated animals should\nbe observed for a few minutes after administration to ensure that part of the dose is not lost\nor rejected. If it is suspected that any of the dose has been lost, redosing is recommended.\nTri-Heart® Plus should be given at monthly intervals during the period of the\nyear when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active.\nThe initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes.\nThe final dose must be given within a month (30 days) after the dog’s last exposure\nto mosquitoes.\nWhen replacing another heartworm preventive product in a heartworm disease preventive\nprogram, the first dose of Tri-Heart® Plus must be given within a month (30\ndays) of the last dose of the former medication.\nIf the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be\nreduced. Therefore, for optimal performance, the chewable tablet must be given once a\nmonth on or about the same day of the month. If treatment is delayed, whether by a few days\nor many, immediate treatment with Tri-Heart® Plus and resumption of the\nrecommended dosing regimen minimizes the opportunity for the development of adult\nheartworms.\nMonthly treatment with Tri-Heart® Plus also provides effective treatment\nand control of roundworms (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala,\nA. braziliense). Clients should be advised of measures to be taken to prevent reinfection with\nintestinal parasites.","Tri-Heart Plus (Ivermectin and Pyrantel)",{"id":282,"dose_text":283,"species":10,"administration_route":263,"limitation":10,"source_label":284},12986,"IVERHART MAX Chew should be administered orally at monthly intervals and the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg\u002F lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg\u002Flb), and 5 mg of praziquantel per kg (2.27 mg\u002Flb) of body weight, as follows:\nDosing Schedule\nDog Weight\nPounds\nChew\nper\nMonth\nChew\nSize\nIvermectin\nContent\nPyrantel\nPamoate\nContent\nPraziquantel\nContent\n6.0 to 12\n1\nToy\n34 mcg\n28.5 mg\n28.5 mg\n12.1 to 25\n1\nSmall\n68 mcg\n57 mg\n57 mg\n25.1 to 50\n1\nMedium\n136 mcg\n114 mg\n114 mg\n50.1 to 100\n1\nLarge\n272 mcg\n228 mg\n228 mg\nIVERHART MAX Chew is recommended for dogs 8 weeks of age or older. For dogs over 100 lbs, use the appropriate combination of these chews. Remove only one dose at a time from the packaging. Return the remaining chew(s) to their box to protect from light. The chew can be offered to the dog by hand or added, intact, to a small amount of dog food. Care should be taken to ensure that the dog consumes the complete dose. The treated dog should be observed for a few minutes after administration to confirm that none of the dose has been lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.\nIVERHART MAX Chew should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes.\nWhen replacing another heartworm preventative product in a heartworm disease prevention program, the first dose of IVERHART MAX Chew must be given within a month (30 days) after the last dose of the former medication. A heartworm test should be performed prior to and 6 months after switching heartworm preventative products.\nIf the interval between doses exceeds a month (30 days), the effectiveness of ivermectin can be reduced. Therefore, for optimal performance, the chew must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with IVERHART MAX Chew and resumption of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms.","IVERHART MAX® Chew (ivermectin\u002Fpyrantel pamoate\u002Fpraziquantel)",{"id":286,"dose_text":287,"species":10,"administration_route":268,"limitation":10,"source_label":288},12987,"Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find VetriShield Plus™ Flavored Chewables palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.\nCare should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended. VetriShield Plus™ Flavored Chewables should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes.\nThe final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes. When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of VetriShield Plus™ Flavored Chewables must be given within a month (30 days) of the last dose of the former medication.\nIf the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the flavored chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with VetriShield Plus™ Flavored Chewables and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.\nMonthly treatment with VetriShield Plus™ Flavored Chewables also provides effective treatment and control of roundworms (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.","VetriShield Plus (ivermectin\u002Fpyrantel pamoate) Flavored Chewables",{"id":290,"dose_text":291,"species":10,"administration_route":263,"limitation":10,"source_label":292},12988,"Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light.\nBecause most dogs find HEARTGARD® PLUS palatable, the product can be offered to the dog by hand. To avoid the risk of choking or intestinal obstruction, the chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing (see Precautions and Post-Approval Experience). Alternatively, it may be added intact to a small amount of dog food to encourage chewing, but care should be taken to ensure that the dog consumes the complete dose at one time.\nTreated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.\nHEARTGARD® PLUS should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes.\nWhen replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of HEARTGARD® PLUS must be given within a month (30 days) of the last dose of the former medication.\nIf the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD® PLUS and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.\nMonthly treatment with HEARTGARD® PLUS also provides effective treatment and control of roundworms (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.","HEARTGARD® PLUS (ivermectin\u002Fpyrantel)",{"id":294,"dose_text":295,"species":10,"administration_route":263,"limitation":10,"source_label":296},12989,"DOSAGE AND TREATMENT:\nExodus® (pyrantel pamoate) Paste is to be administered as a single oral dose of 3 mg pyrantel base per lb of body weight. The syringe has 4 weight mark increments. Each weight mark indicates the recommended dose for 300 lb of body weight.\nDOSAGE\nBody Weight Range\nVolume\nmg Pyrantel Base\nup to 300 lb\n¼ syringe\n900 mg\n301 – 600 lb\n½ syringe\n1800 mg\n601 - 900 lb\n¾ syringe\n2700 mg\n901 - 1200 lb\n1 full syringe\n3600 mg\nNote: Position ring-gauge over appropriate mark on plunger. Each mL contains 171 mg of pyrantel base as pyrantel pamoate.\nDo not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.\nFor maximum control of parasitism, it is recommended that foals (2-8 months of age) be dosed every 4 weeks. To minimize the potential source of infection that the mare may pose to the foal, the mare should be treated 1 month prior to anticipated foaling date by retreatment 10 days to 2 weeks after birth of foal. Horses and ponies over 8 months of age should be routinely dosed every 6 weeks.\nIt is recommended that severely debilitated animals not be treated with this preparation.\nADMINISTRATION:\nAfter removing the cap, the paste should be deposited on the dorsum of the tongue. Introduce the nozzle end of the syringe at the corner of the mouth. Direct the syringe backwards and depress the plunger to deposit the paste onto the tongue. Given in this manner, it is unlikely that rejection of the paste will occur. Raising the horse’s head sometimes assists in the swallowing process. When only part of the paste has been used, replace the cap on the syringe nozzle.\nEFFICACY:\nCritical (worm count) studies in horses demonstrated that pyrantel pamoate administered at the recommended dosage was efficacious against mature infections of Strongylus vulgaris (>90%), S. edentatus (69%), S. equinus (>90%), Oxyuris equi (81%), Parascaris equorum (>90%), and small strongyles (>90%).","FDA application 200-350",{"id":298,"dose_text":299,"species":10,"administration_route":263,"limitation":10,"source_label":296},12990,"DOSAGE AND TREATMENT:\nExodus® Multi-Dose (pyrantel pamoate) Paste is to be administered as a single oral dose of 3 mg pyrantel base per lb of body weight. The syringe has 8 weight mark increments. Each weight mark indicates the recommended dose for 300 lb of body weight. One-half syringe treats a 1200 lb horse.\nDOSAGE\nBody Weight Range\nVolume\nmg Pyrantel Base\nup to 300 lb\n1\u002F8 syringe\n900 mg\n301 - 600 lb\n1\u002F4 syringe\n1800 mg\n601 - 900 lb\n3\u002F8 syringe\n2700 mg\n901 - 1200lb\n1\u002F2 syringe\n3600 mg\nNote: Position ring-gauge over appropriate mark on plunger. Each mL contains 171 mg pyrantel base as pyrantel pamoate.\nDo not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.\nFor maximum control of parasitism, it is recommended that foals (2-8 months of age) be dosed every 4 weeks. To minimize the potential source of infection that the mare may pose to the foal, the mare should be treated 1 month prior to anticipated foaling date followed by retreatment 10 days to 2 weeks after birth of foal. Horses and ponies over 8 months of age should be routinely dosed every 6 weeks.\nADMINISTRATION:\nAfter removing the cap, the paste should be deposited on the dorsum of the tongue. Introduce the nozzle end of the syringe at the corner of the mouth. Direct the syringe backwards and depress the plunger to deposit the paste onto the tongue. Given in this manner, it is unlikely that rejection of the paste will occur. Raising the horse's head sometimes assists in the swallowing process. When only part of the paste has been used, replace the cap on the syringe nozzle.\nEFFICACY:\nCritical (worm count) studies in horses demonstrated that pyrantel pamoate paste administered at the recommended dosage was efficacious against mature infections of Strongylus vulgaris (>90%), S. edentatus (69%), S. equinus (>90%), Oxyuris equi (81%), Parascaris equorum (>90%), and small strongyles (>90%).",{"id":301,"dose_text":302,"species":10,"administration_route":263,"limitation":10,"source_label":296},12991,"DOSAGE AND TREATMENT:\nEquistrength® Paste (pyrantel pamoate) is to be administered as a single oral dose of 3 mg pyrantel base per lb of body weight. The syringe has four weight mark increments. Each weight mark indicates the recommended dose for 300 lb of body weight.\nDOSAGE\nBody Weight Range\nVolume\nmg Pyrantel Base\nup to 300 lb\n1\u002F4 syringe\n900 mg\n301 - 600 lb\n1\u002F2 syringe\n1800 mg\n601 - 900 lb\n3\u002F4 syringe\n2700 mg\n901 - 1200 lb\n1 full syringe\n3600 mg\nNote: Position ring-gauge over appropriate mark on plunger. Each mL contains 171 mg of pyrantel base as pyrantel pamoate.\nDo not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.\nFor maximum control of parasitism, it is recommended that foals (2-8 months of age) be dosed every 4 weeks. To minimize the potential source of infection that the mare may pose to the foal, the mare should be treated 1 month prior to anticipated foaling date followed by re-treatment 10 days to 2 weeks after birth of foal. Horses and ponies over 8 months of age should be routinely dosed every 6 weeks.\nADMINISTRATION:\nAfter removing the cap, the paste should be deposited on the dorsum of the tongue. Introduce the nozzle end of the syringe at the corner of the mouth. Direct the syringe backwards and depress the plunger to deposit the paste onto the tongue. Given in this manner, it is unlikely that rejection of the paste will occur. Raising the horse's head sometimes assists in the swallowing process. When only part of the paste has been used, replace the cap on the syringe nozzle.",{"id":304,"dose_text":305,"species":10,"administration_route":263,"limitation":10,"source_label":306},12992,"Strongid is to be administered on a continuous basis either as a top-dress or mixed in the horse’s daily grain ration at the rate of 1.2 mg\u002Flb (2.64 mg\u002Fkg) of body weight daily. The duration of administration is for the period during which the horse is at risk of exposure to internal parasites.\nFoals may be treated at such time when consistent intake of grain mix is occurring. This is generally between 2 and 3 months of age.\nStrongid may be used in mares at any stage of pregnancy or lactation. Stallion fertility is not affected by the use of Strongid.\nDo not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.\nTypical Mixing Directions to Deliver 1.2 mg\u002Flb (2.64 mg\u002Fkg)\nlb of Medicated Grain Mix per 100 lb of Body Weight\nlb of Strongid 48\nlb of Nonmedicated Feed\nResulting Concentration (g\u002Fton)\n2.00\n2.5\n1997.5\n120\n1.5\n3.3\n1996.7\n160\n0.50\n10.0\n1990.0\n480\n0.20\n25.0\n1975.0\n1200\nlb of Medicated Top-Dress per 100 lb of Body Weight\nlb of Strongid 48\nlb of Nonmedicated Feed\nResulting Concentration (g\u002Fton)\n0.04\n125.0\n1875.0\n6000\n0.025\n200.0\n1800.0\n9600\n0.02\n250.0\n1750.0\n12000\n0.0125\n400.0\n1600.0\n19200","Strongid® 48",{"id":308,"dose_text":309,"species":10,"administration_route":263,"limitation":10,"source_label":310},12993,"Strongid Paste is to be administered as a single oral dose of 3 mg pyrantel base per lb of body weight. The syringe has 4 weight mark increments. Each weight mark indicates the recommended dose for 300 lb of body weight.\nDosage\nBody Weight Range\nVolume\nmg Pyrantel Base\nup to 300 lb\n1\u002F4 syringe (5 mL)\n900 mg\n301-600 lb\n1\u002F2 syringe (10mL)\n1800 mg\n601-900 lb\n3\u002F4 syringe (15 mL)\n2700 mg\n901-1200 lb\n1 full syringe (20 mL)\n3600 mg\nNote: Position screw-gauge over appropriate mark on plunger. Each mL contains 180 mg of pyrantel base as pyrantel pamoate.\nDo not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.\nFor maximum control of parasitism, it is recommended that foals (2–8 months of age) be dosed every 4 weeks. To minimize the potential source of infection that the mare may pose to the foal, the mare should be treated 1 month prior to anticipated foaling date followed by retreatment 10 days to 2 weeks after birth of foal. Horses and ponies over 8 months of age should be routinely dosed every 6 weeks.","Strongid® (pyrantel pamoate) paste",{"id":312,"dose_text":313,"species":10,"administration_route":263,"limitation":10,"source_label":314},12994,"For maximum control and prevention of reinfestation, it is recommended that puppies be treated at 2, 3, 4, 6, 8 and 10 weeks of age. Lactating bitches should be treated 2-3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals to prevent T. canis reinfestation. Administer one full teaspoonful (5 mL) for each 10 lbs. of body weight. For the removal of large roundworms (ascarids) and hookworms. Administer one full teaspoonful (5 mL) for each 10 lbs. of body weight. It is not necessary to withhold food prior to treatment. Dogs usually find this wormer very palatable and will lick the dose from the bowl willingly. If there is a reluctance to accept the dose, mix in a small quantity of dog food to encourage consumption. The presence of large roundworms (ascarids) and hookworms should be confirmed by lab fecal examination. It is recommended that dogs maintained under conditions of constant exposure to worm infestation should have a followup fecal exam within 2 to 4 weeks after first treatment.","Liquid Wormer 2X",{"id":316,"dose_text":317,"species":10,"administration_route":263,"limitation":10,"source_label":318},12995,"Administer one full teaspoon (5 mL) for each 10 pounds of body weight (2.27 mg base per lb. of body weight). Although most dogs have been observed to find this formulation very palatable and willingly consume it undiluted, it may be necessary to mix a small quantity of formulation in the dog's normal ration to encourage consumption. Fasting prior to and after treatment is not necessary.\nFor maximum control and prevention of reinfestation, it is recommended that puppies be treated at 2, 3, 4, 6, 8 and 10 weeks of age. Lactating bitches should be treated 2-3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals to prevent T. canis reinfestation.\nCAUTION: THIS PRODUCT IS A SUSPENSION AND AS SUCH WILL SEPARATE. TO ENSURE UNIFORM RESUSPENSION AND TO ACHIEVE PROPER DOSAGE, IT IS EXTREMELY IMPORTANT THAT THE PRODUCT BE SHAKEN THOROUGHLY BEFORE EVERY USE.","Sentry HC Worm X DSFor Dogs(pyrantel pamoate)",{"id":320,"dose_text":321,"species":10,"administration_route":263,"limitation":10,"source_label":322},12996,"IMPORTANT: SHAKE WELL BEFORE USING\nDOSAGE AND ADMINISTRATION: Administer 1 teaspoon (5 mL) for each 10 lb of body weight. It is not necessary to withhold food prior to or after treatment. Dogs usually find this dewormer very palatable and will lick the dose from the bowl willingly. If there is reluctance to accept the\ndose, mix in a small quantity of dog food to encourage consumption. It is recommended that dogs maintained under conditions of constant exposure to worm infestation should have a follow-up fecal exam within 2-4 weeks after treatment. For maximum control and prevention of reinfestation, it is recommended that puppies be treated at 2, 3, 4, 6, 8, and 10 weeks of age. Lactating bitches should be treated 2-3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals to prevent T. canis reinfestation.","FDA application 200-007",{"id":324,"dose_text":325,"species":10,"administration_route":263,"limitation":10,"source_label":326},12997,"DOSAGE AND ADMINISTRATION:\nDog Worm Tabs Chewable Tablets for Dogs may be given directly in the mouth or offered in a small amount of food. You should weigh your dog to make sure you are using the right size and number of tablets. Administer to dogs and puppies* only as follows:\n*NOT FOR USE IN PUPPIES LESS THAN 3 WEEKS OF AGE OR DOGS WEIGHING LESS THAN 2 LBS.\nDog Worm Tabs\nChewable Tablets for Dogs\nDosage Charts\nfor Puppies and Small Dogs*\n(2 - 25 lbs.)\nBody Wt.\n(lbs.)\nNo. of\nTablets\n2 - 4\n0.5\n5 - 7\n1.0\n8 - 12\n1.5\n13 - 18\n2.0\n19 - 25\n2.5\nfor Medium Dogs\n(26 - 60 lbs.)\nBody Wt.\n(lbs.)\nNo. of\nTablets\n26 - 30\n1.0\n31 - 44\n1.5\n45 - 60\n2.0\nfor Large Dogs\n(45 lbs. and greater)\nBody Wt.\n(lbs.)\nNo. of\nTablets\n45 - 60\n1.0\n61 - 90\n1.5\n91 - 120\n2.0\nFASTING IS NEITHER NECESSARY NOR RECOMMENDED.","FDA application 141-007",{"id":328,"dose_text":329,"species":10,"administration_route":263,"limitation":10,"source_label":330},12998,"Quad Dewormer Chewable Tablets for Dogs may be given directly in the mouth or offered in a small amount of food. You should weigh your dog to make sure you are using the right size and number of tablets. Administer to dogs and puppies* only as follows:\nQuad Dewormer Chewable Tablets for Dogs Dosage Charts\n*NOT FOR USE IN PUPPIES LESS THAN 3 WEEKS OF AGE OR DOGS WEIGHING LESS THAN 2 LBS.\nfor Puppies and Small Dogs*\n(2 - 25 lbs.)\nBody Wt.\n(lbs.)\nNo. of\nTablets\n2 - 4\n0.5\n5 - 7\n1.0\n8 - 12\n1.5\n13 - 18\n2.0\n19 - 25\n2.5\nfor Medium Dogs\n(26 - 60 lbs.)\nBody Wt.\n(lbs.)\nNo. of\nTablets\n26 - 30\n1.0\n31 - 44\n1.5\n45 - 60\n2.0\nfor Large Dogs\n(45 lbs. and greater)\nBody Wt.\n(lbs.)\nNo. of\nTablets\n45 - 60\n1.0\n61 - 90\n1.5\n91 - 120\n2.0\nFASTING IS NEITHER NECESSARY NOR RECOMMENDED.","Elanco™ Quad Dewormer (praziquantel\u002Fpyrantel pamoate\u002Ffebantel)",{"id":332,"dose_text":333,"species":10,"administration_route":268,"limitation":10,"source_label":288},12999,"VetriShield Plus™ (ivermectin\u002Fpyrantel) Flavored Chewables should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg\u002Flb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg\u002Flb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of roundworms and hookworms is as follows:\nDog Weight\nFlavored Chewable Per Month\nIvermectin Content\nPyrantel Content\nUp to 25 lbs\n1\n68 mcg\n57 mg\n26 to 50 lbs\n1\n136 mcg\n114 mg\n51 to 100 lbs\n1\n272 mcg\n227 mg\nVetriShield Plus™ Flavored Chewables are recommended for dogs 6 weeks of age and older. For dogs over 100 lbs use the appropriate combination of these Flavored Chewables.",{"id":335,"dose_text":336,"species":10,"administration_route":263,"limitation":10,"source_label":337},13000,"Each flavored chewable contains 30 mg of pyrantel pamoate and 30 mg of praziquantel. The dose for each drug is 2.27 mg per pound of body weight (5 mg\u002Fkg). Please refer to the following dosing table for help finding the right dose for your dog.\n7 Way De-Wormer Flavored Chewables Dosing Table\n• You should weigh your dog to make sure you are giving the right dose.\n• 7 Way De-Wormer Flavored Chewables are palatable if offered by hand. If your dog does not voluntarily eat the chewable, you can hide the chewable in a small amount of food or place it in the back of the dog's mouth for forced swallowing.\n• Make sure that the dog eats the complete dose.\n• Watch your dog for a few minutes after dosing to make sure the chewable is not rejected.","7 Way De-Wormer (pyrantel pamoate\u002Fpraziquantel) Flavored Chewables",{"id":339,"dose_text":340,"species":10,"administration_route":263,"limitation":10,"source_label":292},13001,"HEARTGARD® PLUS should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg\u002Flb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg\u002Flb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of roundworms and hookworms is as follows:\nHEARTGARD® PLUS is recommended for dogs 6 weeks of age and older.\nFor dogs over 100 lbs use the appropriate combination of these chewables.\nDog Weight\nChewables Per Month\nIvermectin Content\nPyrantel Content\nColor Coding on Foil Backing and Carton\n0 - 25 lbs\n1\n68 mcg\n57 mg\nBlue\n26 - 50 lbs\n1\n136 mcg\n114 mg\nGreen\n51 - 100 lbs\n1\n272 mcg\n227 mg\nBrown",{"id":342,"dose_text":343,"species":10,"administration_route":263,"limitation":10,"source_label":344},13002,"Each flavored chewable contains 114 mg of pyrantel pamoate and 114 mg of praziquantel. The dose for each drug is 2.27 mg per pound of body weight (5 mg\u002Fkg). Please refer to the following dosing table for help finding the right dose for your dog.\nVIRBANTEL Flavored Chewables Dosing Table\nYou should weigh your dog to make sure you are giving the right dose.\nVIRBANTEL Flavored Chewables are palatable if offered by hand. If your dog does not voluntarily eat the chewable, you can hide the chewable in a small amount of food or place it in the back of the dog's mouth for forced swallowing.\nMake sure that the dog eats the complete dose.\nWatch your dog for a few minutes after dosing to make sure the chewable is not rejected.","Virbantel® Flavored Chewables",{"id":346,"dose_text":347,"species":10,"administration_route":32,"limitation":348,"source_label":349},13003,"22.7 mg tablet in puppies and small dogs\nFor the removal of large roundworms (Ascarids) and hookworms, give 1 tablet for each 10 lb of body weight. Dosage is designed to provide at least 2.27 mg per pound body weight for dogs weighing over 5 lb, and at least 4.54 mg per pound of body weight for dogs weighing 5 lb or less. For dogs weighing more than 10 lb, tablets may be broken in half to provide ½ tablet for each additional 5 lb of body weight.\n113.5 mg tablet in large dogs\nFor the removal of large roundworms (Ascarids) and hookworms in adult dogs or young dogs weighing more than 25 lb, administer tablets according to the weight of the animal.","Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Retreatment of adult dogs may be necessary at monthly intervals as determined by laboratory fecal examinations. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism","WormX®",{"id":351,"dose_text":352,"species":10,"administration_route":263,"limitation":10,"source_label":353},13004,"DOSAGE AND ADMINISTRATION:\nTo ensure proper dosage, weigh the cat prior to treatment.\nAdminister as a single oral dose according to the following table.\nDOSAGE TABLE:\nBody Weight: 2–3 lbs\nNumber of Tablets: 0.5 tablet\nBody Weight: 4–8 lbs\nNumber of Tablets: 1.0 tablet\nBody Weight: 9–12 lbs\nNumber of Tablets: 1.5 tablets\nBody Weight: 13–16 lbs\nNumber of Tablets: 2.0 tablets\nNot for use in kittens less than 2 months of age or weighing less\nthan 2 lbs.\nDIRECTIONS FOR USE:\nTablets may be given directly by mouth or offered in a small amount\nof food.\nDo not withhold food from the cat prior to or after treatment.","OZIPCO Fenbendazole CAT DEWORMER",{"id":355,"dose_text":356,"species":10,"administration_route":263,"limitation":10,"source_label":310},13005,"After removing the cap, the paste should be deposited on the dorsum of the tongue. Introduce the nozzle end of the syringe at the corner of the mouth. Direct the syringe backwards and depress the plunger to deposit the paste onto the tongue. Given in this manner, it is unlikely that rejection of the paste will occur. Raising the horse's head sometimes assists in the swallowing process. When only part of the paste has been used, replace the cap on the syringe nozzle.",{"id":358,"dose_text":359,"species":10,"administration_route":263,"limitation":10,"source_label":360},13006,"To assure proper dosage, weigh the cat prior to treatment. Select the number of whole or partial tablets needed for the cat from the following table.\n*NOT FOR USE IN KITTENS LESS THAN TWO MONTHS OF AGE OR WEIGHING LESS THAN 2 LBS.\nBody Weight*\n(lbs.)\nNumber of\nTablets\n2 – 3\n½\n4 – 8\n1\n9 – 12\n1 ½\n13 – 16\n2\nDrontal Tablets may be given directly by mouth or offered in a small amount of food. Do not withhold food from the cat prior to or after treatment.","Elanco™ Drontal™(praziquantel\u002Fpyrantel pamoate)Tablets Broad Spectrum Dewormer For Cats And Kittens",{"id":362,"dose_text":363,"species":10,"administration_route":263,"limitation":10,"source_label":364},13007,"Administer the product once as specified in the following table or as suggested by your veterinarian.\nBody Weight (lbs.)\nNO. of tablets\n2-3\n0.5\n4-8\n1.0\n9-12\n1.5\n13-16\n2.0\nGive orally or mixed with food. Offer a dosage as a single treatment or as recommended.\nDewormer tablets may be given directly by mouth or offered in a small amount of food. Do not withhold food from the cat prior to or after treatment.","Broad Spectrum Cat & Dog Dewormer (praziquantel \u002F pyrantel pamoate) tablets",{"id":366,"dose_text":367,"species":10,"administration_route":263,"limitation":10,"source_label":368},13008,"• Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.\n• Do not de-worm a dog or puppy that is sick. Consult a veterinarian for diagnosis of the illness.\n• 7 Way De-Wormer Flavored Chewables are safe for use in puppies 12 weeks or older and adult dogs. Safety in breeding dogs and pregnant bitches has not been tested.","FDA application 141-261",{"id":370,"dose_text":371,"species":10,"administration_route":263,"limitation":10,"source_label":264},13009,"Complete Swine Feeds Containing 0.0106% (96 g\u002Ft) Pyrantel Tartrate\nAmount of Banminth 48\nper Ton of Complete Feed\nResultant Use Level of PyranteTartrate in Complete Feed\nIndications for Use\n16.67 lb\n0.0881%\n(800g\u002Ft)\nFor the removal and control of large roundworm (A. suum) and nodular worm (Oesophagostomum)infections in swine.†",{"id":373,"dose_text":374,"species":10,"administration_route":263,"limitation":10,"source_label":375},13010,"NexGard® PLUS is given orally once a month at the minimum dosage of 1.14 mg\u002Flb (2.5 mg\u002Fkg) afoxolaner, 5.45 mcg\u002Flb (12 mcg\u002Fkg) moxidectin, and 2.27 mg\u002Flb (5.0 mg\u002Fkg) pyrantel (as pamoate salt).\nFor heartworm disease prevention, give once monthly for at least six months after last exposure to mosquitoes (see Effectiveness).","NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets)",{"id":377,"dose_text":378,"species":10,"administration_route":263,"limitation":10,"source_label":379},13011,"To assure proper dosage, weigh the cat prior to treatment. Select the number of whole or partial tablets needed for the cat from the following table.\nTablets may be given directly by mouth or offered in a small amount of food. Do not withhold food from the cat prior to or after treatment.","FDA application 141-008",{"id":381,"dose_text":382,"species":10,"administration_route":263,"limitation":10,"source_label":383},13012,"Give orally or in food ONCE a day for 3 consecutive days. Recommended to treat every 3-4 months.\nDosage Chart:\nDog\u002FCat Weight\nDose\n5 lbs\n1 ml\n10 lbs\n2 ml\n20 lbs\n4 ml\n30 lbs\n6 ml\n40 lbs\n8 ml\nOver 40lbs\nuse combination to obtain dose.\nShake well before use.","GiarCidia Zap-Wormer",{"id":385,"dose_text":386,"species":10,"administration_route":32,"limitation":10,"source_label":387},13013,"Shake well before use. Give 1 mL per 5 lbs body weight. Administer orally, or in food once per day for 3 consecutive days.\nDOSAGE CHART:\nUp to 5 lbs: 1 mL\n10 lbs: 2 mL\n20 lbs: 4 mL\n30 lbs: 6 mL\n40 lbs: 8 mL\n*over 40 lbs, dose at 1 mL per 5 lbs body weight","Vetr FenTel (5% fenbendazole, 2.5% pyrantel suspension)",{"id":389,"dose_text":390,"species":10,"administration_route":263,"limitation":10,"source_label":391},13014,"Administer 1 teaspoon (5 mL) for each 5 lb of body weight. To assure proper dosage, weigh animal prior to treatment. It is not necessary to withhold food prior to treatment.","RFD®",{"id":393,"dose_text":394,"species":10,"administration_route":263,"limitation":10,"source_label":395},13015,"Each mL of Pyrantel Pamoate Oral Suspension contains the equivalent of 50 mg of Pyrantel Base (as Pyrantel Pamoate).","PyraMax Pyrantel Pamoate Suspension (50 mg\u002FmL pyrantel base)",[397,401,405,408,410,414,417,420,422,425,427,431,433,436,438,440,442,445,447,449,451,455,460,463,467,469,471,476,478,481,484,486,489,493,495,497,499,501,503,505,507,509,511,513,515,518,522,526,530,533,536,539,542,544,547,550,553,556,559,561,565,568,571,575,578,581,583,585,588,591,595,598,601,604,607,611,614,617,620,623,626,629,632],{"id":398,"strength_text":399,"dosage_form":400,"proprietary_name":33,"species":31,"source_label":33},11210,"Type A medicated articles: 48 grams per pound.","Top Dressing In Feed",{"id":402,"strength_text":403,"dosage_form":404,"proprietary_name":49,"species":47,"source_label":49},11211,"Pyrantel pamoate suspension contains pyrantel pamoate equivalent to 50 milligrams of pyrantel base per milliliter.","Liquid (Suspension)",{"id":406,"strength_text":407,"dosage_form":404,"proprietary_name":60,"species":53,"source_label":60},11212,"Pyrantel pamoate suspension contains pyrantel pamoate equivalent to 2.27 or 4.54 milligrams of pyrantel base per milliliter.",{"id":409,"strength_text":407,"dosage_form":404,"proprietary_name":60,"species":64,"source_label":60},11213,{"id":411,"strength_text":412,"dosage_form":413,"proprietary_name":76,"species":69,"source_label":76},11214,"Each chewable tablet contains either 68 micrograms of ivermectin and 57 milligrams of pyrantel (as pamoate salt), or 136 micrograms ivermectin and 114 milligrams pyrantel, or 272 micrograms and 227 milligrams, respectively.","Tablet (Chewable)",{"id":415,"strength_text":416,"dosage_form":413,"proprietary_name":85,"species":69,"source_label":85},11215,"Each tablet contains pyrantel pamoate equivalent to 22.7 or 113.5 milligrams pyrantel base.",{"id":418,"strength_text":419,"dosage_form":400,"proprietary_name":43,"species":31,"source_label":43},11216,"Type A medicated articles containing pyrantel tartrate 48 grams per pound.",{"id":421,"strength_text":403,"dosage_form":404,"proprietary_name":112,"species":106,"source_label":112},11217,{"id":423,"strength_text":424,"dosage_form":413,"proprietary_name":118,"species":116,"source_label":118},11218,"Each chewable tablet contains: 30 mg praziquantel and 30 mg pyrantel pamoate (For Small Dogs and Puppies) or 114 mg praziquantel and 114 mg pyrantel pamoate (For Medium and Large Dogs).",{"id":426,"strength_text":424,"dosage_form":413,"proprietary_name":118,"species":121,"source_label":118},11219,{"id":428,"strength_text":424,"dosage_form":429,"proprietary_name":430,"species":121,"source_label":430},11220,"Chewable Tablets","Worm X Plus®",{"id":432,"strength_text":424,"dosage_form":429,"proprietary_name":430,"species":116,"source_label":430},11221,{"id":434,"strength_text":435,"dosage_form":413,"proprietary_name":127,"species":125,"source_label":127},11222,"Each chewable tablet contains:\n(1) 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel;\n(2) 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel;\n(3) 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel; or\n(4) 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel.",{"id":437,"strength_text":435,"dosage_form":413,"proprietary_name":127,"species":131,"source_label":127},11223,{"id":439,"strength_text":435,"dosage_form":413,"proprietary_name":127,"species":135,"source_label":127},11224,{"id":441,"strength_text":435,"dosage_form":413,"proprietary_name":127,"species":139,"source_label":127},11225,{"id":443,"strength_text":444,"dosage_form":404,"proprietary_name":144,"species":53,"source_label":144},11226,"Pyrantel pamoate suspension contains pyrantel pamoate equivalent to 4.54 milligrams of pyrantel base per milliliter.",{"id":446,"strength_text":444,"dosage_form":404,"proprietary_name":144,"species":142,"source_label":144},11227,{"id":448,"strength_text":407,"dosage_form":404,"proprietary_name":55,"species":53,"source_label":55},11228,{"id":450,"strength_text":407,"dosage_form":404,"proprietary_name":55,"species":148,"source_label":55},11229,{"id":452,"strength_text":453,"dosage_form":454,"proprietary_name":178,"species":153,"source_label":178},11230,"Type A medicated articles containing pyrantel tartrate 9.6 and 19.2 grams per pound","Medicated Feed",{"id":456,"strength_text":457,"dosage_form":458,"proprietary_name":459,"species":153,"source_label":459},11231,"Type A medicated articles containing pyrantel tartrate 19.2 and 48 grams per pound.","Type A Medicated Article","CHECK-R-TON ™ BM",{"id":461,"strength_text":462,"dosage_form":400,"proprietary_name":189,"species":188,"source_label":189},11232,"Pyrantel tartrate pellets colt and horse wormer contains 1.25 percent pyrantel tartrate.",{"id":464,"strength_text":465,"dosage_form":458,"proprietary_name":466,"species":153,"source_label":466},11233,"Type A medicated article containing pyrantel tartrate 48 grams per pound.","BANMINTH® 48",{"id":468,"strength_text":403,"dosage_form":404,"proprietary_name":199,"species":192,"source_label":199},11234,{"id":470,"strength_text":462,"dosage_form":400,"proprietary_name":194,"species":192,"source_label":194},11235,{"id":472,"strength_text":473,"dosage_form":474,"proprietary_name":475,"species":192,"source_label":475},11236,"Each milliliter of paste contains 226 milligrams of pyrantel base (as pyrantel pamoate).","Paste","Pyrantel Pamoate Paste",{"id":477,"strength_text":412,"dosage_form":413,"proprietary_name":102,"species":69,"source_label":102},11237,{"id":479,"strength_text":480,"dosage_form":474,"proprietary_name":107,"species":106,"source_label":107},11238,"Each milliliter of paste contains 171 milligrams of pyrantel base (as pyrantel pamoate).",{"id":482,"strength_text":407,"dosage_form":404,"proprietary_name":483,"species":53,"source_label":483},11239,"Primex® 2-X",{"id":485,"strength_text":407,"dosage_form":404,"proprietary_name":203,"species":202,"source_label":203},11240,{"id":487,"strength_text":403,"dosage_form":404,"proprietary_name":488,"species":192,"source_label":488},11241,"Primex™ Equine",{"id":490,"strength_text":491,"dosage_form":492,"proprietary_name":209,"species":207,"source_label":209},11242,"Each tablet contains either:\n1) 22.7 milligrams praziquantel, 22.7 milligrams pyrantel base, and 113.4 milligrams febantel\n2) 68 milligrams praziquantel, 68 milligrams pyrantel base, and 340.2 milligrams febantel\nor\n3) 136 milligrams praziquantel, 136 milligrams pyrantel base, and 680.4 milligrams febantel","Tablet",{"id":494,"strength_text":491,"dosage_form":492,"proprietary_name":209,"species":213,"source_label":209},11243,{"id":496,"strength_text":491,"dosage_form":492,"proprietary_name":209,"species":217,"source_label":209},11244,{"id":498,"strength_text":491,"dosage_form":492,"proprietary_name":209,"species":221,"source_label":209},11245,{"id":500,"strength_text":491,"dosage_form":492,"proprietary_name":209,"species":225,"source_label":209},11246,{"id":502,"strength_text":491,"dosage_form":492,"proprietary_name":209,"species":229,"source_label":209},11247,{"id":504,"strength_text":491,"dosage_form":492,"proprietary_name":209,"species":233,"source_label":209},11248,{"id":506,"strength_text":491,"dosage_form":492,"proprietary_name":209,"species":237,"source_label":209},11249,{"id":508,"strength_text":491,"dosage_form":492,"proprietary_name":209,"species":241,"source_label":209},11250,{"id":510,"strength_text":491,"dosage_form":492,"proprietary_name":209,"species":245,"source_label":209},11251,{"id":512,"strength_text":491,"dosage_form":492,"proprietary_name":250,"species":248,"source_label":250},11252,{"id":514,"strength_text":491,"dosage_form":492,"proprietary_name":250,"species":253,"source_label":250},11253,{"id":516,"strength_text":517,"dosage_form":492,"proprietary_name":259,"species":257,"source_label":259},11254,"Each tablet contains 18.2 mg praziquantel and 72.6 mg pyrantel base as pyrantel pamoate.",{"id":519,"strength_text":520,"dosage_form":454,"proprietary_name":521,"species":153,"source_label":521},11255,"Type A medicated articles containing pyrantel tartrate 19.2 grams per pound","BN Wormer-19.2 Banminth® Premix",{"id":523,"strength_text":524,"dosage_form":454,"proprietary_name":525,"species":153,"source_label":525},11256,"Type A medicated articles containing pyrantel tartrate 9.6 grams per pound. Consult veterinarian before using in severely debilitated animals. Do not mix in Type B or Type C medicated feeds containing bentonite.","Custom Ban Wormer 9.6",{"id":527,"strength_text":528,"dosage_form":454,"proprietary_name":529,"species":153,"source_label":529},11257,"Type A medicated articles containing pyrantel tartrate 9.6 and 19.2 grams per pound.","INI Swine Ban-Wormer B-9 19.2 BA.",{"id":531,"strength_text":528,"dosage_form":454,"proprietary_name":532,"species":153,"source_label":532},11258,"Worm-Ban 10",{"id":534,"strength_text":528,"dosage_form":454,"proprietary_name":535,"species":153,"source_label":535},11259,"Q.T. Ban-Tech",{"id":537,"strength_text":528,"dosage_form":454,"proprietary_name":538,"species":153,"source_label":538},11260,"Ban-A-Worm Py. Tartrate",{"id":540,"strength_text":541,"dosage_form":458,"proprietary_name":168,"species":153,"source_label":168},11261,"Type A medicated articles containing pyrantel tartrate 9.6, 19.2, and 80 grams per pound. Type A medicated articles containing 10, 40, or 100 grams per pound tylosin phosphate.",{"id":543,"strength_text":453,"dosage_form":454,"proprietary_name":173,"species":153,"source_label":173},11262,{"id":545,"strength_text":416,"dosage_form":413,"proprietary_name":546,"species":69,"source_label":546},11263,"Adams™",{"id":548,"strength_text":412,"dosage_form":413,"proprietary_name":549,"species":69,"source_label":549},11264,"Heartgard® Plus",{"id":551,"strength_text":552,"dosage_form":492,"proprietary_name":90,"species":69,"source_label":90},11265,"Each tablet contains pyrantel pamoate equivalent to 22.7, 45.4, or 113.5 milligrams of pyrantel base.",{"id":554,"strength_text":555,"dosage_form":458,"proprietary_name":154,"species":153,"source_label":154},11266,"Type A medicated articles containing 20 or 50 grams per pound lincomycin as lincomycin hydrochloride. Type A medicated articles containing 9.6, 19.2, 48, or 80 grams per pound pyrantel tartrate.",{"id":557,"strength_text":407,"dosage_form":404,"proprietary_name":558,"species":53,"source_label":558},11267,"Nemex",{"id":560,"strength_text":407,"dosage_form":404,"proprietary_name":558,"species":202,"source_label":558},11268,{"id":562,"strength_text":563,"dosage_form":474,"proprietary_name":564,"species":192,"source_label":564},11269,"Each milliliter of paste contains 180 milligrams of pyrantel base (as pyrantel pamoate).","Banminth®-P Paste",{"id":566,"strength_text":453,"dosage_form":454,"proprietary_name":567,"species":153,"source_label":567},11270,"Ban-A-Worm II",{"id":569,"strength_text":528,"dosage_form":454,"proprietary_name":570,"species":153,"source_label":570},11271,"Swine Guard-BN Banminth® Premix",{"id":572,"strength_text":573,"dosage_form":574,"proprietary_name":349,"species":10,"source_label":349},11272,"Each tablet contains pyrantel pamoate equivalent to 22.7 mg or 113.5 mg pyrantel base","Flavored Tablets",{"id":576,"strength_text":453,"dosage_form":454,"proprietary_name":577,"species":153,"source_label":577},11273,"Cadco-BN-10 Banminth® Premix",{"id":579,"strength_text":453,"dosage_form":454,"proprietary_name":580,"species":153,"source_label":580},11274,"Pyrantel Tartrate Ton Pack",{"id":582,"strength_text":419,"dosage_form":400,"proprietary_name":306,"species":31,"source_label":306},11275,{"id":584,"strength_text":528,"dosage_form":454,"proprietary_name":183,"species":153,"source_label":183},11276,{"id":586,"strength_text":528,"dosage_form":454,"proprietary_name":587,"species":153,"source_label":587},11277,"Banminth® Intermediate Premix",{"id":589,"strength_text":528,"dosage_form":454,"proprietary_name":590,"species":153,"source_label":590},11278,"Swine Guard-BN",{"id":592,"strength_text":593,"dosage_form":594,"proprietary_name":154,"species":153,"source_label":154},11279,"Type A medicated articles containing 20 or 50 grams per pound lincomycin as lincomycin hydrochloride agricultural grade.","Type A medicated articles for use in the manufacture of Type B and Type C medicated feeds",{"id":596,"strength_text":597,"dosage_form":429,"proprietary_name":71,"species":69,"source_label":71},11280,"Each chewable tablet contains either: 1) 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel; 2) 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel; 3) 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel; or 4) 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel.",{"id":599,"strength_text":600,"dosage_form":429,"proprietary_name":98,"species":69,"source_label":98},11281,"Each chewable tablet contains either: 3.0 mg sarolaner \u002F 0.06 mg moxidectin \u002F 12.5 mg pyrantel (as pamoate salt), 6.0 mg sarolaner \u002F 0.12 mg moxidectin \u002F 25.0 mg pyrantel (as pamoate salt), 12.0 mg sarolaner \u002F 0.24 mg moxidectin \u002F 50.0 mg pyrantel (as pamoate salt), 24.0 mg sarolaner \u002F 0.48 mg moxidectin \u002F 100 mg pyrantel (as pamoate salt), 48.0 mg sarolaner \u002F 0.96 mg moxidectin \u002F 200 mg pyrantel (as pamoate salt) or 72.0 mg sarolaner \u002F 1.44 mg moxidectin \u002F 300 mg pyrantel (as pamoate salt)",{"id":602,"strength_text":603,"dosage_form":429,"proprietary_name":80,"species":69,"source_label":80},11282,"Each chewable tablet contains 9.375 mg afoxolaner, 45 mcg moxidectin, and 18.75 mg pyrantel; 18.75 mg afoxolaner, 90 mcg moxidectin, and 37.5 mg pyrantel; 37.5 mg afoxolaner, 180 mcg moxidectin, and 75 mg pyrantel; 75 mg afoxolaner, 360 mcg moxidectin, and 150 mg pyrantel; or 150 mg afoxolaner, 720 mcg moxidectin, and 300 mg pyrantel.",{"id":605,"strength_text":606,"dosage_form":429,"proprietary_name":94,"species":69,"source_label":94},11283,"56.25 mg lotilaner, 0.056 mg moxidectin, 14.25 mg praziquantel, and 14.25 mg pyrantel; 112.5 mg lotilaner, 0.113 mg moxidectin, 28.5 mg praziquantel, and 28.5 mg pyrantel; 225 mg lotilaner, 0.225 mg moxidectin, 57 mg praziquantel, and 57 mg pyrantel; 450 mg lotilaner, 0.45 mg moxidectin, 114 mg praziquantel, and 114 mg pyrantel; 900 mg lotilaner, 0.9 mg moxidectin, 228 mg praziquantel, and 228 mg pyrantel",{"id":608,"strength_text":609,"dosage_form":429,"proprietary_name":610,"species":69,"source_label":610},11284,"Each chewable tablet contains: 56.25 mg lotilaner, 0.056 mg moxidectin, 14.25 mg praziquantel, and 14.25 mg pyrantel* 112.5 mg lotilaner, 0.113 mg moxidectin, 28.5 mg praziquantel, and 28.5 mg pyrantel* 225 mg lotilaner, 0.225 mg moxidectin, 57 mg praziquantel, and 57 mg pyrantel* 450 mg lotilaner, 0.45 mg moxidectin, 114 mg praziquantel, and 114 mg pyrantel* 900 mg lotilaner, 0.9 mg moxidectin, 228 mg praziquantel, and 228 mg pyrantel* *As pamoate salt","Credelio Quattro™-CA1",{"id":612,"strength_text":613,"dosage_form":10,"proprietary_name":10,"species":10,"source_label":314},11285,"4.54 mg \u002F 1 mL",{"id":615,"strength_text":616,"dosage_form":10,"proprietary_name":10,"species":10,"source_label":391},11286,"2.27 mg \u002F 1 mL",{"id":618,"strength_text":619,"dosage_form":10,"proprietary_name":10,"species":10,"source_label":306},11287,"105.8 g \u002F 1 kg",{"id":621,"strength_text":622,"dosage_form":10,"proprietary_name":10,"species":10,"source_label":296},11288,"7.2 g \u002F 47.2 g",{"id":624,"strength_text":625,"dosage_form":10,"proprietary_name":10,"species":10,"source_label":296},11289,"3.6 g \u002F 23.6 g",{"id":627,"strength_text":628,"dosage_form":10,"proprietary_name":10,"species":10,"source_label":310},11290,"180 mg \u002F 1 mL",{"id":630,"strength_text":631,"dosage_form":10,"proprietary_name":10,"species":10,"source_label":264},11291,"48 g \u002F 0.45 kg",{"id":633,"strength_text":634,"dosage_form":10,"proprietary_name":10,"species":10,"source_label":395},11292,"50 mg \u002F 1 mL",[636,640,643,646,649,652,654,657,660,663,666,669,672,676,679,682,685,688,691,694,697,699,702,704,706,708,711,713,716,719,722,726,730,733,736,740,743,746,748,751,754,758,760,763,765,768,770,772,774,776,778,780,782,784,786,788,790,792,794,796,798,800,802,805,808,811,814,817,820,823,826,829,833,836,839,843,846,849,852,855,859,862,865,868,872,875,878,881,884,888,891,894,897,901,904,907,910,913,916,919,922,925,928,931,934,937,940,944,947,950,953,956,959,962,965,968,971,974,978,981,984,987,990,993,996,999,1002,1005,1008,1011,1014,1017,1020,1023,1026,1030,1033],{"id":637,"kind":638,"statement":639,"species":31,"limitation":10,"source_label":33},18924,"indication","For the prevention of Strongylus vulgaris larval infestation in horses; For control of the following parasites in horses: LARGE STRONGYLES (adults) - S. vulgaris, S. edentatus; SMALL STRONGYLES (adults and fourth-stage larvae) - Cyathostomum spp., Cylicocyclus spp., Cylicostephanus spp., Cylicodontophorus spp., Poteriostomum spp., Triodontophorus spp.; PINWORMS (adults and fourth-stage larvae) - Oxyuris equi; ASCARIDS (adults and fourth-stage larvae) - Parascaris equorum",{"id":641,"kind":638,"statement":642,"species":31,"limitation":42,"source_label":43},18925,"Prevention of Strongylus vulgaris larval infections; control of adult large strongyles (S. vulgaris, S. edentatus); adult and 4th stage larvae small strongyles (Cyathostomum species, Cylicocyclus species., Cylicostephanus species, Cylicodontophorus species, Poteriostomum species); Triodontophorus species; adult and 4th stage larvae pinworms (Oxyuris equi) and adult and 4th stage larvae ascarids (Parascaris equorum).",{"id":644,"kind":638,"statement":645,"species":31,"limitation":37,"source_label":38},18926,"For the removal and control of infections from the following mature parasites: Large strongyles (Strongylus vulgaris, Strongylus edentatus, Strongylus equinus), small strongyles, pinworms (Oxyuris equi) and large roundworms (Parascaris).",{"id":647,"kind":638,"statement":648,"species":47,"limitation":48,"source_label":49},18927,"For the removal and control of infections from the following mature parasites: Large strongyles (Strongylus vulgaris Strongylus edentatus, Strongylus equinus), small strongyles pinworms (Oxyuris), and large roundworms (Parascaris).",{"id":650,"kind":638,"statement":651,"species":53,"limitation":59,"source_label":60},18928,"For the removal of large roundworms (Toxocara canis and Toxascarias leonina) and hookworms (Ancylostoma caninum and Uncinaria stenocephala).",{"id":653,"kind":638,"statement":58,"species":53,"limitation":59,"source_label":558},18929,{"id":655,"kind":638,"statement":656,"species":64,"limitation":65,"source_label":60},18930,"To prevent reinfections of Toxocara canis.",{"id":658,"kind":638,"statement":659,"species":69,"limitation":10,"source_label":98},18931,"Simparica TRIO® is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections. Simparica TRIO® kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated dog, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. Simparica TR O® is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.",{"id":661,"kind":638,"statement":662,"species":69,"limitation":10,"source_label":94},18932,"Credelio Quattro™ is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (fourth stage larvae, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus) infections. Credelio Quattro™ kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma Americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater. Credelio Quattro™ is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.",{"id":664,"kind":638,"statement":665,"species":69,"limitation":10,"source_label":80},18933,"For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of adult hookworm (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala) and roundworm (Toxocara canis and Toxascaris leonina) infections. Kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of Ixodes scapularis (blacklegged tick), Rhipicephalus sanguineus (brown dog tick), Dermacentor variabilis (American dog tick), Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), and Haemaphysalis longicornis (longhorned tick) infestations for one month in dogs and puppies eight weeks of age and older, weighing four pounds of body weight or greater. For the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.",{"id":667,"kind":638,"statement":668,"species":69,"limitation":70,"source_label":71},18934,"For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense), and tapeworms (Dipylidium caninum, Taenia pisiformis).",{"id":670,"kind":638,"statement":671,"species":69,"limitation":75,"source_label":102},18935,"To prevent canine heartworm disease by eliminating the tissue larval stages of Dirofilaria immitis for up to a month (30 days) after infection and treatment and control of adult ascarids Toxocara canis and Toxascaris leonina, and adult hookworms Ancylostoma caninum, A. braziliense, and Uncinaria stenocephala.",{"id":673,"kind":638,"statement":674,"species":69,"limitation":675,"source_label":549},18936,"To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection. For the treatment and control of ascarids (Toxocara canis, Toxascaris leonine), and hookworms (Ancylostoma caninum, A braziliense, and Uncinaria stenocephala).","Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus.",{"id":677,"kind":638,"statement":678,"species":69,"limitation":75,"source_label":76},18937,"Ivermectin: to prevent canine heartworm diseases by eliminating the tissue larval stage of Dirofilaria immitis for a month (30 days) after infection. Pyrantel pamoate: for the treatment and control of adult Toxocara canis, Toxascaris leonina, Ancylostoma caninum, A braziliense, and Uncinaria stenocephala.",{"id":680,"kind":638,"statement":681,"species":69,"limitation":84,"source_label":85},18938,"For removal of ascarids (Toxocara canis; Toxascaris leonina), and hookworms (Ancylostoma caninum; Uncinaria stenocephala) in dogs and puppies. To prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping.",{"id":683,"kind":638,"statement":684,"species":69,"limitation":10,"source_label":610},18939,"For the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.",{"id":686,"kind":638,"statement":687,"species":69,"limitation":89,"source_label":90},18940,"For removal and control of large roundworms (ascarids) (Toxocara canis and Toxascaris leonina), and hookworms (Ancylostoma caninum and Uncinaria stenocephala).",{"id":689,"kind":638,"statement":690,"species":106,"limitation":10,"source_label":107},18941,"For removal and control of infections from the following mature parasites: large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); small strongyles; pinworms (Oxyuris equi); and large roundworms (Parascaris equorum).",{"id":692,"kind":638,"statement":693,"species":106,"limitation":111,"source_label":112},18942,"For the removal and control of mature infections of large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); pinworms (Oxyuris equi); large roundworms (Parascaris\nequorum); and small strongyles.",{"id":695,"kind":638,"statement":696,"species":116,"limitation":117,"source_label":118},18943,"For the treatment and control of roundworms (Toxocara canis and Toxascaris leonine), hookworms (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala), and tapeworms (Dipylidium caninum and Taenia pisiformis) in dogs and puppies.",{"id":698,"kind":638,"statement":696,"species":121,"limitation":117,"source_label":118},18944,{"id":700,"kind":638,"statement":701,"species":125,"limitation":126,"source_label":127},18945,"Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonine), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and tapeworm (Dipylidium caninum, Taenia pisiformis) infections.",{"id":703,"kind":638,"statement":701,"species":131,"limitation":126,"source_label":127},18946,{"id":705,"kind":638,"statement":701,"species":135,"limitation":126,"source_label":127},18947,{"id":707,"kind":638,"statement":701,"species":139,"limitation":126,"source_label":127},18948,{"id":709,"kind":638,"statement":710,"species":142,"limitation":143,"source_label":144},18949,"To prevent reinfections of Toxocara canis",{"id":712,"kind":638,"statement":656,"species":148,"limitation":149,"source_label":55},18950,{"id":714,"kind":638,"statement":715,"species":153,"limitation":158,"source_label":159},18951,"For control of swine dysentery (vibrionic dysentery, bloody scours or hemorrhagic dysentery); control of bacterial swine enteritis (salmonellosis or necrotic enteritis caused by Salmonella choleraesuis); aid in the prevention of migration and establishment of large roundworm (Ascaris suum) infections; aid in the prevention of establishment of nodular worm (Oesophagostomum) infections.",{"id":717,"kind":638,"statement":718,"species":153,"limitation":10,"source_label":154},18952,"For reduction in the severity of the effects of respiratory disease associated with Mycoplasma hyopneumoniae; to aid in the prevention of migration and establishment of large roundworm (Ascaris suum) infections; to aid in the prevention of establishment of nodular worm (Oesophagostomum spp.) infections in swine.",{"id":720,"kind":638,"statement":721,"species":153,"limitation":167,"source_label":168},18953,"For treatment and control of swine dysentery (vibrionic); immediately after medicating with tylosin in drinking water; aid in the prevention of migration and establishment of large roundworm (Ascaris suum) infections; and as an aid in the prevention of establishment of nodular worm (Oesophagostomum) infections.",{"id":723,"kind":638,"statement":724,"species":153,"limitation":725,"source_label":168},18954,"For prevention of swine dysentery (vibrionic); aid in the prevention of migration and establishment of large roundworms (Ascaris suum) infections; and as an aid in the prevention of establishment of nodular worm (Oesophagostomum) infections.","Feed continuously as the sole ration until market weight. This feed is for use following the feeding of 100 g per ton tylosin for at least 3 weeks. Do not use in any finished feed (supplement, concentrate or complete feed) containing bentonite. Withdraw 24 hours prior to slaughter.",{"id":727,"kind":638,"statement":728,"species":153,"limitation":729,"source_label":154},18955,"For treatment and\u002For control of swine dysentery; aid in the prevention of migration and establishment of large roundworm (Ascaris suum) infections; aid in the prevention of establishment of nodular worm (Oesophagostomum spp.) infections.","For treatment of swine dysentery, feed 100 grams of lincomycin and 96 grams of pyrantel tartrate per ton of complete feed for three weeks or until clinical signs of the disease (watery, mucoid, or bloody stools) disappear. Once clinical signs have disappeared, control swine dysentery by following with 40 grams of lincomycin and 96 grams of pyrantel tartrate per ton of complete feed as the sole ration. Not to be fed to swine that weigh more than 250 pounds. Do not mix in feeds containing bentonite. Occasionally, swine fed lincomycin may within the first two days after the onset of treatment develop diarrhea and\u002For swelling of the anus. On rare occasions, some pigs may show reddening of the skin and irritable behavior. These conditions have been self-correcting within five to eight days without discontinuing the lincomycin treatment. The effects of lincomycin on swine reproductive performance, pregnancy, and lactation have not been determined. Do not allow rabbits, hamsters, guinea pigs, horses, or ruminants access to feeds containing lincomycin. Ingestion by these species may result in severe gastrointestinal effects. Withdraw 6 days before slaughter.",{"id":731,"kind":638,"statement":732,"species":153,"limitation":182,"source_label":178},18956,"Aid in the prevention of migration and establishment of large roundworm (Ascaris suum) infections; aid in the prevention of establishment of nodular worm (Oesophagostomum) infections.",{"id":734,"kind":638,"statement":735,"species":153,"limitation":163,"source_label":154},18957,"For treatment and\u002For control of swine dysentery; for removal and control of large roundworm (Ascaris suum) and nodular worm (Oesophagostomum species) infections.",{"id":737,"kind":638,"statement":738,"species":153,"limitation":739,"source_label":154},18958,"For treatment and\u002For control of swine dysentery; for removal and control of large roundworm (Ascaris suum) infections.","Feed for 3 days as the sole ration. Not to be fed to swine that weigh more than 250 pounds. Do not mix in feeds containing bentonite. Occasionally, swine fed lincomycin may within the first two days after the onset of treatment develop diarrhea and\u002For swelling of the anus. On rare occasions, some pigs may show reddening of the skin and irritable behavior. These conditions have been self-correctingwithin five to eight days without discontinuing the lincomycin treatment. The effects of lincomycin on swine reproductive performance, pregnancy, and lactation have not been determined. Do not allow rabbits, hamsters, guinea pigs, horses, or ruminants access to feeds containing lincomycin. Ingestion by these species may result in severe gastrointestinal effects. Withdraw 24 hours prior to slaughter.",{"id":741,"kind":638,"statement":742,"species":153,"limitation":177,"source_label":178},18959,"For the removal and control of large roundworm (Ascaris suum) and nodular worm (Oesophagostomum) infections.",{"id":744,"kind":638,"statement":745,"species":153,"limitation":172,"source_label":535},18960,"For the removal and the control of large roundworms (Ascaris suum) infections",{"id":747,"kind":638,"statement":645,"species":188,"limitation":37,"source_label":189},18961,{"id":749,"kind":638,"statement":750,"species":192,"limitation":193,"source_label":194},18962,"For the removal and control of infections from the following mature parasites: Large strongyles (Strongylus vulgaris, Strongylus edentatus, Strongylus equinus), small strongyles (Trichonema species, Triodontophorus), pinworms (Oxyuris) and large roundworms (Parascaris).",{"id":752,"kind":638,"statement":690,"species":192,"limitation":753,"source_label":475},18963,"Administer as single dose by depositing paste on dorsum of the tongue using the dose syringe. Not for use in horses intended for food. It is recommended that severely debilitated animals not be treated with this preparation. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.",{"id":755,"kind":638,"statement":756,"species":192,"limitation":757,"source_label":475},18964,"For the removal and control of mature infections of tapeworms (Anoplocephala perfoliata).","Administer as single oral dose. Not for use in horses intended for food.",{"id":759,"kind":638,"statement":656,"species":202,"limitation":65,"source_label":203},18965,{"id":761,"kind":638,"statement":762,"species":207,"limitation":208,"source_label":209},18966,"For the removal of tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus); hookworms (Ancylostoma caninum, Uncinaria stenocephala); ascarids (Toxocara canis, Toxascaris leonina); and whipworms (Trichuris vulpis) and for removal and control of tapeworm (Echinococcus multilocularis).",{"id":764,"kind":638,"statement":762,"species":213,"limitation":208,"source_label":209},18967,{"id":766,"kind":638,"statement":767,"species":217,"limitation":249,"source_label":250},18968,"Quad Dewormer (praziquantel\u002Fpyrantel pamoate\u002Ffebrantel) Chewable Tablets for Dogs will remove the common tapeworms, Dipylidium caninum and Taenia pisiformis, remove common hookworms, Ancylostoma caninum and Uncinaria stenocephala, remove common roundworms, Toxocara canis and Toxascaris leonina, and remove whipworms, Trichuris vulpis in dogs.",{"id":769,"kind":638,"statement":762,"species":217,"limitation":208,"source_label":209},18969,{"id":771,"kind":638,"statement":767,"species":221,"limitation":249,"source_label":250},18970,{"id":773,"kind":638,"statement":762,"species":221,"limitation":208,"source_label":209},18971,{"id":775,"kind":638,"statement":767,"species":225,"limitation":249,"source_label":250},18972,{"id":777,"kind":638,"statement":762,"species":225,"limitation":208,"source_label":209},18973,{"id":779,"kind":638,"statement":767,"species":229,"limitation":249,"source_label":250},18974,{"id":781,"kind":638,"statement":762,"species":229,"limitation":208,"source_label":209},18975,{"id":783,"kind":638,"statement":767,"species":233,"limitation":249,"source_label":250},18976,{"id":785,"kind":638,"statement":762,"species":233,"limitation":208,"source_label":209},18977,{"id":787,"kind":638,"statement":767,"species":237,"limitation":249,"source_label":250},18978,{"id":789,"kind":638,"statement":762,"species":237,"limitation":208,"source_label":209},18979,{"id":791,"kind":638,"statement":767,"species":241,"limitation":249,"source_label":250},18980,{"id":793,"kind":638,"statement":762,"species":241,"limitation":208,"source_label":209},18981,{"id":795,"kind":638,"statement":767,"species":245,"limitation":249,"source_label":250},18982,{"id":797,"kind":638,"statement":762,"species":245,"limitation":208,"source_label":209},18983,{"id":799,"kind":638,"statement":767,"species":248,"limitation":249,"source_label":250},18984,{"id":801,"kind":638,"statement":767,"species":253,"limitation":249,"source_label":250},18985,{"id":803,"kind":638,"statement":804,"species":257,"limitation":258,"source_label":259},18986,"For removal of the common parasites of cats and kittens including tapeworms (Dipylidium caninum, Taenia taeniaeformis), hookworms (Ancylostoma tubaeforme), and large roundworms (Toxocara cati).",{"id":806,"kind":638,"statement":807,"species":10,"limitation":10,"source_label":360},18987,"Drontal (praziquantel\u002Fpyrantel pamoate) tablets will remove Tapeworms (Dipylidium caninum, Taenia taeniaeformis), Hookworms (Ancylostoma tubaeforme), and Large Roundworms (Toxocara cati) in cats and kittens.\nThe presence of tapeworms is indicated by the observance of tapeworm segments passed in the cat's feces. Tapeworm segments are white, pinkish-white or yellow-white in color and are similar in size and shape to flattened grains of rice. The segments are most frequently observed lying on a freshly passed stool. Segments may also be found on the hair around the anus of the animal or on the animal's bedding. Cats become infected with tapeworms after eating fleas or small mammals (rabbits, mice) which may be infected with tapeworm larvae.\nHookworms are small whitish or reddish-brown worms less than one inch in length that live in the intestinal tract and feed on blood. Cats can become infected with hookworms by swallowing infected larvae while grooming or when larvae from the environment burrow through the skin. Cats infected with hookworms may have poor physical condition, dull haircoat, and reduced body weight and diarrhea, sometimes with the presence of dark blood.\nLarge roundworms are white or yellow-white strands 2-7 inches in length (similar in size and color to smooth strings of spaghetti) that may be observed in the cat's vomit or feces. Cats become infected with large roundworms by swallowing infective eggs, particularly while grooming, or by ingestion of mice that may be infected with larval stages.\nLarge roundworms and hookworms pass eggs in the feces of the cat that can only be observed with the aid of a microscope.\nThe presence of these parasites should be confirmed through identification of parasite eggs in the feces.\nConsult your veterinarian for assistance in the diagnosis, treatment and control of parasites.\nLarge roundworms and hookworms may be observed in the feces of the cat a day or so after the cat has been treated with Drontal Tablets. The majority of tapeworms, however, are digested and are not found in the feces after treatment.",{"id":809,"kind":638,"statement":810,"species":10,"limitation":10,"source_label":273},18988,"Credelio Quattro is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (fourth stage larvae, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus) infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater. Credelio Quattro is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.\nCredelio Quattro-CA1 is indicated for the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.",{"id":812,"kind":638,"statement":813,"species":10,"limitation":10,"source_label":391},18989,"For the removal of large roundworms (Toxocara canis and Toxascaris leonina) and hookworms (Ancylostoma caninum and Uncinaria stenocephala) in dogs and puppies. The presence of these parasites should be confirmed by laboratory fecal exam. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.\nRFD Liquid Wormer may also be used to prevent reinfestation of T. canis in puppies and adult dogs and in lactating bitches after whelping.\nDogs usually find this dewormer very palatable and will lick the dose from the bowl willingly. If there is reluctance to accept the dose, mix in a small quantity of dog food to encourage consumption. It is recommended that dogs maintained under conditions of constant exposure to worm infestation should have a follow-up fecal exam within 2–4 weeks after first treatment. If your dog looks or acts sick, consult your veterinarian before treatment.\nFor maximum control and prevention of reinfestation, it is recommended that puppies be treated at 2, 3, 4, 6, 8 and 10 weeks of age. Lactating bitches should be treated 2–3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals to prevent T. canis reinfestation.",{"id":815,"kind":638,"statement":816,"species":10,"limitation":10,"source_label":98},18990,"SIMPARICA TRIO is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections. SIMPARICA TRIO kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated dog, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma\nmaculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. SIMPARICA TRIO is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.",{"id":818,"kind":638,"statement":819,"species":10,"limitation":10,"source_label":322},18991,"Pyrid 2x\n(pyrantel pamoate oral suspension)\nCanine Anthelmintic Suspension\nNOT FOR USE IN HUMANS\nDESCRIPTION: Pyrid 2x liquid wormer is a suspension of pyrantel pamoate in a palatable\nbutterscotch flavored vehicle. Each mL contains 4.54 mg of pyrantel base as pyrantel pamoate.\nPyrantel pamoate is a compound belonging to a family classified chemically as tetrahydropyrimidines.\nIt is a yellow, water-insoluble crystalline salt of the tetrahydropyrimidine base and pamoic\nacid containing 34.7% base activity. The chemical structure and name are given below:\nINDICATIONS AND USAGE: Pyrid 2x suspension is a highly palatable formulation intended as a\nsingle treatment for the removal of large roundworms (Toxocara canis and Toxascaris leonina) and\nhookworms (Ancylostoma caninum and Uncinaria stenocephala) in dogs and puppies. The presence\nof these parasites should be confirmed by laboratory fecal exam. Consult your veterinarian for\nassistance in the diagnosis, treatment, and control of parasitism.\nPyrid 2x suspension may also be used to prevent reinfestation of T.canis in puppies and adult dogs\nand in lactating bitches after whelping.",{"id":821,"kind":638,"statement":822,"species":10,"limitation":10,"source_label":375},18992,"NexGard® PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of adult hookworm (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala) and roundworm (Toxocara canis and Toxascaris\nleonina) infections. NexGard® PLUS kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of Ixodes\nscapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), Dermacentor variabilis (American dog tick), Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick) and Haemaphysalis longicornis (longhorned tick) infestations for one month in dogs and puppies eight weeks of age and older, weighing four pounds of body weight or greater. NexGard® PLUS is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.",{"id":824,"kind":638,"statement":825,"species":10,"limitation":10,"source_label":344},18993,"Each flavored chewable contains 30 mg of pyrantel pamoate and 30 mg of praziquantel. The dose for each drug is 2.27 mg per pound of body weight (5 mg\u002Fkg). Please refer to the following dosing table for help finding the right dose for your dog.\nVIRBANTEL® Flavored Chewables Dosing Table\nYou should weigh your dog to make sure you are giving the right dose.\nVIRBANTEL Flavored Chewables are palatable if offered by hand. If your dog does not voluntarily eat the chewable, you can hide the chewable in a small amount of food or place it in the back of the dog's mouth for forced swallowing.\nMake sure that the dog eats the complete dose.\nWatch your dog for a few minutes after dosing to make sure the chewable is not rejected.",{"id":827,"kind":638,"statement":828,"species":10,"limitation":10,"source_label":368},18994,"Each flavored chewable contains 114 mg of pyrantel pamoate and 114 mg of praziquantel. The dose for each drug is 2.27 mg per pound of body weight (5 mg\u002Fkg). Please refer to the following dosing table for help finding the right dose for your dog.\nYou should weigh your dog to make sure you are giving the right dose.\n7 Way De-Wormer Flavored Chewables are palatable if offered by hand. If your dog does not voluntarily eat the chewable, you can hide the chewable in a small amount of food or place in the back of the dog's mouth for forced swallowing.\nMake sure that the dog eats the complete dose.\nWatch your dog for a few minutes after dosing to make sure the chewable is not rejected.",{"id":830,"kind":638,"statement":831,"species":10,"limitation":10,"source_label":832},18995,"Nemex-2 suspension is a highly palatable formulation intended as a single treatment for the removal of large roundworms (Toxocara canis and Toxascaris leonina) and hookworms (Ancylostoma caninum and Uncinaria stenocephala) in dogs and puppies. The presence of these parasites should be confirmed by laboratory fecal exam. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.\nNemex-2 suspension may also be used to prevent reinfestation of T. canis in puppies and adult dogs and in lactating bitches after whelping.","NEMEX®-2",{"id":834,"kind":638,"statement":835,"species":10,"limitation":10,"source_label":318},18996,"WormX DS suspension is a highly palatable formulation intended as a single treatment for the removal of large roundworms (Toxocara canis and Toxacaris leonina), and hookworms (Ancylostoma caninum and Uncinaria stenocephala) in dogs and puppies.\nWormX DS suspension may also be used to prevent reinfestation of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping.\nConsult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.",{"id":837,"kind":638,"statement":838,"species":10,"limitation":10,"source_label":306},18997,"For the prevention of Strongylus vulgaris larval infestation in horses.\nFor control of the following parasites in horses:\nLarge Strongyles (adults): S. vulgaris, S. edentatus\nSmall Strongyles (adults and fourth-stage larvae): Cyathostomum spp., Cylicocyclus spp., Cylicostephanus spp., Cylicodontophorus spp., Poteriostomum spp., Triodontophorus spp.\nPinworms (adults and fourth-stage larvae): Oxyuris equi\nAscarids (adults and fourth-stage larvae): Parascaris equorum",{"id":840,"kind":638,"statement":841,"species":10,"limitation":10,"source_label":842},18998,"Drontal Plus (praziquantel\u002Fpyrantel pamoate\u002Ffebantel) Taste Tabs Broad Spectrum Chewable Anthelmintic Tablets are indicated for removal of Tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and removal and control of Echinococcus multilocularis) and for removal of Hookworms (Ancylostoma caninum, Uncinaria stenocephala), Ascarids (Toxocara canis, Toxascaris leonina), and Whipworms (Trichuris vulpis) in dogs.","Elanco DrontalTM Plus (praziquantel\u002Fpyrantel pamoate\u002Ffebantel) Taste TabsTM Broad Spectrum Chewable Anthelmintic Tablets for Dogs",{"id":844,"kind":638,"statement":845,"species":10,"limitation":10,"source_label":326},18999,"Drontal Plus (praziquantel\u002Fpyrantel pamoate\u002F febantel) Broad Spectrum Anthelmintic Tablets are indicated for removal of Tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and removal and control of Echincoccus multilocularis). For removal of Hookworms (Ancylostoma caninum, Uncinaria stenocephala), Ascarids (Toxocara canis, Toxascaris leonina), and Whipworms (Trichuris vulpis) in dogs.",{"id":847,"kind":638,"statement":848,"species":10,"limitation":10,"source_label":284},19000,"For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma\ncaninum, Uncinaria stenocephala, Ancylostoma braziliense), and tapeworms (Dipylidium caninum, Taenia pisiformis).",{"id":850,"kind":638,"statement":851,"species":10,"limitation":10,"source_label":264},19001,"For the removal and control of large roundworm (Ascaris suum) and nodular worm (Oesophagostomum)infections in swine.\nAid in the prevention of migration and establishment of large roundworm (A. suum) infections; aid in the prevention of establishment of nodular worm (Oesophagostomum)infections in swine.\nFor the removal and control of large roundworm (A. suum)infections in swine.",{"id":853,"kind":638,"statement":854,"species":10,"limitation":10,"source_label":314},19002,"To prevent reinfestation of (Toxocara canis) in puppies and adult dogs and in lactating bitches after whelping.\nFor the removal of large roundworms, (Toxocara canis and Toxascaris leonina) and hookworms, (Ancylostoma caninum and Uncinaria stenocephala) in dogs and puppies.\nConsult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.",{"id":856,"kind":638,"statement":857,"species":10,"limitation":10,"source_label":858},19003,"INDICATIONS: For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxoscaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancyclostoma braziliense).","HeartArmor Plus (ivermectin \u002F pyrantel)",{"id":860,"kind":638,"statement":861,"species":10,"limitation":10,"source_label":326},19004,"Dog Worm Tabs (praziquantel\u002F pyrantel pamoate\u002F febantel) Chewable Tablets for Dogs will remove the common tapeworms, Dipylidium caninum and Taenia pisiformis, remove common hookworms, Ancylostoma caninum and Uncinaria stenocephala, remove common roundworms, Toxocara canis and Toxascaris leonina, and remove whipworms, Trichuris vulpis in dogs.",{"id":863,"kind":638,"statement":864,"species":10,"limitation":10,"source_label":296},19005,"INDICATIONS FOR USE:\nFor the removal and control of mature infections of large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); small strongyles; pinworms (Oxyuris equi); and large roundworms (Parascaris equorum) in horses and ponies.\nConsult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.",{"id":866,"kind":638,"statement":867,"species":10,"limitation":348,"source_label":349},19006,"For removal of ascarids (Toxocara canis; Toxascaris leonina), and hookworms (Ancylostoma caninum; Uncinaria stenocephala) in dogs and puppies. To prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping",{"id":869,"kind":638,"statement":870,"species":10,"limitation":10,"source_label":871},19007,"For the treatment and control of:\n• Roundworms (Toxocara canis, Toxascaris leonina)\n• Hookworms (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala)\n• Tapeworms (Dipylidium caninum, Taenia pisiformis)","Triple Wormer® (pyrantel pamoate\u002Fpraziquantel) Flavored Chewables",{"id":873,"kind":638,"statement":874,"species":10,"limitation":10,"source_label":364},19008,"For removal of the common parasites of cats, kittens and dogs including Tapeworms (Dipylidium caninum, Taenia taeniaeformis), Hookworms (Ancylostoma tubaeforme) and Large Roundworms (Toxocara cati).",{"id":876,"kind":638,"statement":877,"species":10,"limitation":10,"source_label":871},19009,"• Tapeworms (Dipylidium caninum, Taenia pisiformis)\n• Roundworms (Toxocara canis, Toxascaris leonina)\n• Hookworms (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala)",{"id":879,"kind":638,"statement":880,"species":10,"limitation":10,"source_label":353},19010,"Praziquantel\u002FPyrantel Pamoate Tablets are a broad-spectrum dewormer\nfor the removal and control of tapeworms, roundworms, and hookworms\nin cats and kittens.",{"id":882,"kind":638,"statement":883,"species":10,"limitation":10,"source_label":395},19011,"For the treatment of pinworms",{"id":885,"kind":886,"statement":887,"species":10,"limitation":10,"source_label":842},19012,"contraindication","DO NOT USE IN PREGNANT ANIMALS. Dogs treated with elevated levels (6 consecutive days with 3 times the labeled dosage rate) of the combination of febantel and praziquantel in early pregnancy demonstrated an increased incidence of abortion and fetal abnormalities.8 The effects of Drontal Plus Anthelmintic Tablets on pregnant animals have not been determined.\nThere are no known contraindications against the use of praziquantel or pyrantel pamoate in dogs.",{"id":889,"kind":886,"statement":890,"species":10,"limitation":10,"source_label":273},19013,"There are no known contraindications for the use of Credelio Quattro\u002FCredelio Quattro-CA1.",{"id":892,"kind":886,"statement":893,"species":10,"limitation":10,"source_label":98},19014,"There are no known contraindications for the use of SIMPARICA TRIO.",{"id":895,"kind":886,"statement":896,"species":10,"limitation":10,"source_label":375},19015,"There are no known contraindications for the use of NexGard® PLUS.",{"id":898,"kind":899,"statement":900,"species":10,"limitation":10,"source_label":375},19016,"warning","Margin of Safety:\nNexGard® PLUS was administered orally at 1, 3, and 5X the maximum exposure doses at approximately 28-day intervals for six treatments to 8-week-old Beagle puppies. Dogs in the control group were sham-dosed. There were no clinically relevant, treatment-related effects on body weights, food consumption, clinical pathology (hematology, coagulation, serum chemistry, and urinalysis), gross pathology, histopathology, organ weights, or ophthalmic examinations. Mild, self-limiting diarrhea (with and without blood) was possibly related to treatment, as there were more incidences in the NexGard® PLUS groups than the control group throughout the study, including within 48 hours after treatment.\nAvermectin-Sensitive Collie Safety:\nNexGard® PLUS was administered orally at 1, 3, and 5X the maximum label dose to MDR1-deficient Collies once on Day 0, with a second administration to the 1X group on Day 28. Dogs in the control group were sham-dosed on Days 0 and 28. No clinical signs of avermectin toxicity were noted in any dog at any time during the study. Vomiting was observed in some dogs in the 3X and 5X groups and resolved without treatment. Diarrhea, with or without blood, was observed in some dogs in all of the NexGard® PLUS groups and resolved without treatment.\nHeartworm-Positive Safety:\nNexGard® PLUS was administered orally at 1X and 3X the maximum exposure doses at approximately 28-day intervals for three treatments to Beagle dogs with adult heartworm infections and circulating microfilariae. Dogs in the control group were sham-dosed. Diarrhea was observed in one dog in the 1X group and in three dogs in the 3X group, and vomiting was observed in two dogs in the 3X group. No signs of avermectin toxicity were observed at any time during the study. There were no clinical signs associated with death of the microfilariae observed in any of the dogs.\nField Safety:\nIn a well-controlled field study, NexGard® PLUS was used concurrently with other medications such as vaccines, antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), anesthetics, sedatives, analgesics, steroids, anthelmintics, antiemetics, and antipruritics. No adverse reactions were associated with the concurrent use of NexGard® PLUS and other medications.",{"id":902,"kind":899,"statement":903,"species":10,"limitation":10,"source_label":296},19017,"WARNINGS\nFor oral animal use only. Do not use in horses intended for human consumption.\nHUMAN WARNINGS:\nKeep out of the reach of children.\nIt is recommended that severely debilitated animals not be treated with this preparation.\nOTHER WARNINGS: Parasite resistance may develop to any dewormer, and has been reported for most classes of dewormers. Treatment with a dewormer used in conjunction with parasite management practices appropriate to the geographic area and the animal(s) to be treated may slow the development of parasite resistance. Fecal examinations or other diagnostic tests and parasite management history should be used to determine if the product is appropriate for the herd prior to the use of any dewormer. Following the use of any dewormer, effectiveness of treatment should be monitored (for example, with the use of a fecal egg count reduction test or another appropriate method). A decrease in a drug's effectiveness over time as calculated by fecal egg count reduction tests may indicate the development of resistance to the dewormer administered. Your parasite management plan should be adjusted accordingly based on regular monitoring.\nTo report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov\u002Freportanimalae.",{"id":905,"kind":899,"statement":906,"species":10,"limitation":10,"source_label":306},19018,"CAUTION: For use in manufacturing of equine feeds only.\nCAUTION: Certain components of animal feeds, including medicated premixes, possess properties that may be a potential health hazard or a source of personal discomfort to certain individuals who are exposed to them. Human exposure should, therefore, be minimized by observing the general industry standards for occupational health and safety.\nPrecautions such as the following should be considered: dust masks or respirators and protective clothing should be worn; dust-arresting equipment and adequate ventilation should be utilized; personal hygiene should be observed; wash before eating or leaving a work site; be alert for signs of allergic reactions—seek prompt medical treatment if such reactions are suspected.",{"id":908,"kind":899,"statement":909,"species":10,"limitation":10,"source_label":871},19019,"Keep this and all medication out of the reach of children. To obtain product information, including a Safety Data Sheet (SDS), call 1-800-821-5570.\nWhen Using This Product:\n• Consult your veterinarian for assistance in the diagnosis, treatment,\nand control of parasitism.\n• Do not de-worm a dog or puppy that is sick. Consult a veterinarian for diagnosis of the illness.\n• Triple Wormer\nFlavored Chewables are safe for use in puppies 12 weeks or older and adult dogs. Safety in breeding dogs and pregnant bitches has not been tested.",{"id":911,"kind":899,"statement":912,"species":10,"limitation":10,"source_label":284},19020,"For use in dogs only. Keep this and all drugs out of reach of children and pets. In safety studies\nwith ivermectin\u002Fpyrantel pamoate\u002Fpraziquantel tablets, testicular hypoplasia was observed in some\ndogs receiving 3 and 5 times the maximum recommended dose monthly for 6 months (see Animal\nSafety).\nIn case of ingestion by humans, clients should be advised to contact a physician immediately.\nPhysicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.",{"id":914,"kind":899,"statement":915,"species":10,"limitation":10,"source_label":395},19021,"Keep this medication in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose\nKeep this and all medications out of reach of children.\nIn case of accidental overdose, seek professional assistance or contact a Poison Control Center immediately.\nIf your pet is pregnant or has liver disease, do not take this product unless directed by a veterinarian.",{"id":917,"kind":899,"statement":918,"species":10,"limitation":10,"source_label":360},19022,"KEEP OUT OF REACH OF CHILDREN.\nConsult your veterinarian before administering to sick or pregnant animals.\nQuestions\u002FComments?\nFor product questions or to report side effects, contact Elanco US Inc. at 1-888-545-5973.\nFor additional information about reporting side effects for animal drugs, contact FDA at 1-888-FDA-VETS or http:\u002F\u002Fwww.fda.gov\u002Freportanimalae",{"id":920,"kind":899,"statement":921,"species":10,"limitation":10,"source_label":273},19023,"Not for use in humans. Keep this and all drugs out of reach of children. Wash hands after handling. If accidentally ingested, seek medical attention immediately.\nKeep Credelio Quattro\u002FCredelio Quattro-CA1 in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.",{"id":923,"kind":899,"statement":924,"species":10,"limitation":10,"source_label":375},19024,"Not for use in humans. Keep this and all drugs out of the reach of children. In case of accidental ingestion, contact a physician for treatment advice.\nKeep NexGard® PLUS in a secure location out of the reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.",{"id":926,"kind":899,"statement":927,"species":10,"limitation":10,"source_label":353},19025,"WARNINGS:\nKeep out of reach of children.\nCAUTIONS:\nDo not use in kittens less than 8 weeks of age or weighing less\nthan 2 lbs.\nUse with caution in sick or debilitated animals.\nConsult your veterinarian before administering to sick or pregnant\nanimals.",{"id":929,"kind":899,"statement":930,"species":10,"limitation":10,"source_label":288},19026,"Keep this and all drugs out of the reach of children.\nIn case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.",{"id":932,"kind":899,"statement":933,"species":10,"limitation":10,"source_label":264},19027,"Withdraw 24 hours prior to slaughter.\nCAUTION: Consult your veterinarian before using in severely debilitated animals.\nDo not mix in feeds containing bentonite.\nNOT FOR HUMAN USE\nRESTRICTED DRUG (CALIFORNIA) – USE ONLY AS DIRECTED",{"id":935,"kind":899,"statement":936,"species":10,"limitation":10,"source_label":296},19028,"WARNINGS\nFor oral animal use only. Do not use in horses intended for human consumption.\nHUMAN WARNINGS:\nKeep out of the reach of children.\nIt is recommended that severely debilitated animals not be treated with this preparation.",{"id":938,"kind":899,"statement":939,"species":10,"limitation":10,"source_label":98},19029,"Not for use in humans. Keep this and all drugs out of reach of children.\nKeep SIMPARICA TRIO in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.",{"id":941,"kind":899,"statement":942,"species":10,"limitation":10,"source_label":943},19030,"For animal use only. Keep out of reach of children.\nConsult a veterinarian before use on sick or pregnant animals.\nNot for use in kittens less than 2 months of age or weighing less than 2 lbs.","LFHYM Broad Spectrum Cat Dewormer (praziquantel\u002Fpyrantel pamoate) tablets",{"id":945,"kind":899,"statement":946,"species":10,"limitation":10,"source_label":364},19031,"*NOT FOR USE IN PUPPIES LESS THAN 2 WEEKS OF AGE OR KITTENS LESS THAN 6 WEEKS OF AGE.\nCAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.",{"id":948,"kind":899,"statement":949,"species":10,"limitation":10,"source_label":310},19032,"Do not use in horses intended for human consumption. Keep out of reach of children.\nIt is recommended that severely debilitated animals not be treated with this preparation.",{"id":951,"kind":899,"statement":952,"species":10,"limitation":10,"source_label":322},19033,"KEEP OUT OF REACH OF CHILDREN. Keep WORM PROTECTOR 2X in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.",{"id":954,"kind":899,"statement":955,"species":10,"limitation":10,"source_label":368},19034,"Keep this and all medication out of the reach of children. To obtain product information, including a Safety Data Sheet (SDS), call call +1 5165860254.",{"id":957,"kind":899,"statement":958,"species":10,"limitation":10,"source_label":387},19035,"Do not administer to puppies and kittens under 2 weeks of age. May be given to pregnant or lactating females. KEEP OUT OF REACH OF CHILDREN.",{"id":960,"kind":899,"statement":961,"species":10,"limitation":10,"source_label":288},19036,"Use product on or before its expiration date.\nDiscard or return unused tablets.",{"id":963,"kind":899,"statement":964,"species":10,"limitation":10,"source_label":306},19037,"Do not use in horses intended for human consumption.",{"id":966,"kind":899,"statement":967,"species":10,"limitation":10,"source_label":330},19038,"KEEP OUT OF REACH OF CHILDREN.\nUSE DIRECTIONS",{"id":969,"kind":899,"statement":970,"species":10,"limitation":10,"source_label":264},19039,"Withdraw 24 hours prior to slaughter.",{"id":972,"kind":899,"statement":973,"species":10,"limitation":10,"source_label":391},19040,"Keep out of reach of children.",{"id":975,"kind":976,"statement":977,"species":10,"limitation":10,"source_label":273},19041,"adverse_reaction","In a field safety and effectiveness study, Credelio Quattro was administered to dogs for the prevention of heartworm disease. The study included a total of 372 dogs treated once monthly for up to 11 treatments (191 treated with Credelio Quattro and 181 treated with an active control). Over the 330-day study period, all observations of potential adverse reactions were recorded.\nAdverse reactions seen during the field study are summarized in the table below.\nDogs with Adverse Reactions in the Field Study\n*Four dogs administered Credelio Quattro and five dogs administered the active control had bloody diarrhea.\nClinical Sign\nCredelio Quattro\nN=191\nNumber (Percentage)\nActive Control\nN=181\nNumber (Percentage)\nDiarrhea, with or without blood*\n21 (11%)\n15 (8.3%)\nVomiting\n18 (9.4%)\n8 (4.4%)\nLethargy\n12 (6.3%)\n1 (0.6%)\nAnorexia\n11 (5.8%)\n5 (2.8%)\nDermatitis\n10 (5.2%)\n8 (4.4%)\nWeight Loss\n6 (3.1%)\n3 (1.7%)\nPruritus (itching)\n3 (1.6%)\n1 (0.6%)\nAlopecia (hair loss)\n2 (1.0%)\n4 (2.2%)\nSeizure\n1 (0.5%)\n4 (2.2%)\nAtaxia\n1 (0.5%)\n1 (0.6%)\nNystagmus\n1 (0.5%)\n0 (0.0%)\nAnisocoria\n1 (0.5%)\n1 (0.6%)\nOne geriatric dog receiving Credelio Quattro experienced two episodes of vomiting, ataxia, and nystagmus, 11 days apart, with the first episode occurring two days after the eighth dose. The dog recovered within 24 hours after the first episode and 1 hour after the second episode and completed the study. One dog receiving Credelio Quattro was observed by the investigator to have anisocoria during scheduled physical examinations one month after the ninth dose and one month after the eleventh dose.\nIn a second U.S. field safety and effectiveness study, Credelio Quattro was administered to 103 dogs with hookworms. Adverse reactions in dogs treated with Credelio Quattro included gastrointestinal signs (diarrhea, emesis) and lethargy.\nIn a U.S. field study, 165 dogs received a combination of lotilaner, moxidectin, and praziquantel, three of the active ingredients at the same doses as in Credelio Quattro, monthly for up to 11 months. Two dogs with no history of seizures experienced seizures during the study. One of the dogs developed cluster seizures and was removed from the study. Ataxia was also observed in one other dog three days after the first dose.\nIn a U.S. field study, one dog administered lotilaner alone, a component of Credelio Quattro, was observed with intermittent head tremors within 1.5 hours of administration of vaccines, an ear cleaning performed by the owner, and its first dose of lotilaner. The head tremors resolved within 24 hours without treatment. The owner elected to withdraw the dog from the study.\nIn an Australian field study, one dog with a history of seizures experienced seizure activity (tremors and glazed eyes) six days after receiving lotilaner alone. The dog recovered without treatment and completed the study. In a U.S. field study, two dogs with a history of seizures received lotilaner alone and experienced no seizures throughout the study.",{"id":979,"kind":976,"statement":980,"species":10,"limitation":10,"source_label":858},19042,"ADVERSE REACTIONS: In clinical field trials with ivermectin\u002Fpyrantel, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses).\nPOST-APPROVAL EXPERIENCE: The following adverse events are based on post-approval adverse drug experience reporting for ivermectin\u002Fpyrantel. Not all adverse events are reported to FDA\u002FCVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data.\nThe following adverse events reported in dogs are listed in decreasing order of reporting frequency:\nvomiting, diarrhea, lethargy, anorexia, seizures, ataxia, muscle tremors, and hypersalivation, pruritus.\nIn some cases, choking or intestinal obstruction has been reported after administration of ivermectin\u002Fpyrantel.\nCONTACT INFORMATION: Contact PET’S CHOICE® at 1-866-462-1702 or PetsChoicePharmaceuticals.com. To report suspected adverse drug experiences, contact PET’S CHOICE at 1-866-462-1702. For additional information about reporting adverse drug experiences for animal drugs, contact FDA at 1-888-FDA-VETS or http:\u002F\u002Fwww.fda.gov\u002Freportanimalae. To obtain a Safety Data Sheet(s), contact PET’S CHOICE at 1-866-462-1702 or PetsChoicePharmaceuticals.com.",{"id":982,"kind":976,"statement":983,"species":10,"limitation":10,"source_label":280},19043,"ADVERSE REACTIONS: In clinical field trials with ivermectin\u002Fpyrantel, vomiting or diarrhea\nwithin 24 hours of dosing was observed (1.1% of administered doses).\n​POST-APPROVAL EXPERIENCE:​ The following adverse events are based on post-approval adverse\ndrug experience reporting for ivermectin\u002Fpyrantel. Not all adverse events are reported to FDA\u002FCVM.\nIt is not always possible to reliably estimate the adverse event frequency or establish a causal\nrelationship to product exposure using these data.\nThe following adverse events reported in dogs are listed in decreasing order of reporting frequency:\nVomiting, diarrhea, lethargy, anorexia, seizures, ataxia, muscle tremors, hypersalivation, pruritus.\nIn some cases, choking or intestinal obstruction has been reported after administration of\nivermectin\u002Fpyrantel.\nContact Information: Contact Merck Animal Health at 1-800-224-5318 or www.TriHeartPlus.com.\nTo report suspected adverse drug experiences, contact Merck Animal Health at 1-800-224-5318.\nFor additional information about reporting adverse drug experiences for animal drugs, contact FDA\nat 1-888-FDA-VETS or http:\u002F\u002Fwww.fda.gov\u002Freportanimalae To obtain a Safety Data Sheet(s), contact\nMerck Animal Health at 1-800-224-5318 or www.Tri-HeartPlus.com.",{"id":985,"kind":976,"statement":986,"species":10,"limitation":10,"source_label":284},19044,"In a field study with IVERHART MAX Chew, self-limiting adverse reactions, including vomiting, diarrhea, lethargy, difficulty swallowing, excessive salivation, increased water consumption, and coughing were reported. Self-limiting adverse reactions, including lethargy, limpness, salivation, shaking, diarrhea, decreased appetite, licking lips, and belching were reported between 20 minutes and 72 hours following treatment in a field study with ivermectin\u002Fpyrantel pamoate\u002Fpraziquantel tablets.\nIn field studies with ivermectin\u002Fpyrantel\u002Fpraziquantel pamoate tablets, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported in dogs following the use of ivermectin products: depression\u002Flethargy, vomiting,anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions, and hypersalivation.\nTo report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Virbac AH, Inc. at 1-800-338-3659 or us.virbac.com. For additional information about adverse drug experience reporting for animal drugs, contact the FDA at 1-888-FDA-VETS or www.fda.gov\u002Freportanimalae.",{"id":988,"kind":976,"statement":989,"species":10,"limitation":10,"source_label":98},19045,"In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. The study included a total of 410 dogs treated once monthly for 11 treatments (272 treated with SIMPARICA TRIO and 138 treated with an active control). Over the 330-day study period, all observations of potential adverse reactions were recorded. The most frequent reactions reported in the SIMPARICA TRIO group are presented in the following table.\nTable 1. Dogs with Adverse Reactions\nClinical Sign\nSIMPARICA TRIO\nn = 272\nActive Control\nn = 138\nVomiting\n14.3%\n10.9%\nDiarrhea\n13.2%\n8.0%\nLethargy\n8.5%\n6.5%\nAnorexia\n5.1%\n5.8%\nPolyuria\n3.7%\n3.6%\nHyperactivity\n2.2%\n0.7%\nPolydipsia\n2.2%\n2.9%\nIn a second field safety and effectiveness study, SIMPARICA TRIO was administered to 278 dogs with fleas. Adverse reactions in dogs treated with SIMPARICA TRIO included diarrhea.\nIn a third field safety and effectiveness study, SIMPARICA TRIO was administered to 120 dogs with roundworms. Adverse reactions in dogs treated with SIMPARICA TRIO included diarrhea and vomiting.\nIn one well-controlled laboratory study, one dog had a seizure 16 days after administration of SIMPARICA TRIO.",{"id":991,"kind":976,"statement":992,"species":10,"limitation":10,"source_label":292},19046,"In clinical field trials with HEARTGARD® PLUS, vomiting or diarrhea within 24 hours of dosing was observed (1.1% of administered doses).\nPost-Approval Experience (2022): The following adverse events are based on post-approval adverse drug experience reporting for HEARTGARD® PLUS. Not all adverse events are reported to FDA\u002FCVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data.\nThe following adverse events reported in dogs are listed in decreasing order of reporting frequency:\nVomiting, diarrhea, lethargy, anorexia, seizures, ataxia, muscle tremors, hypersalivation, pruritus.\nIn some cases, choking or intestinal obstruction has been reported after administration of HEARTGARD® PLUS.\nContact Information: To report suspected adverse drug events, for technical assistance, or to obtain a copy of the Safety Data Sheet (SDS), contact Boehringer Ingelheim Animal Health USA Inc. at 1-888-637-4251. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS, or www.fda.gov\u002Freportanimalae.",{"id":994,"kind":976,"statement":995,"species":10,"limitation":10,"source_label":269},19047,"ADVERSE REACTIONS: In clinical trials with ivermectin\u002Fpyrantel, vomiting or diarrhea within 24 hours of dosing was observed (1.1% of administered doses).\nPOST-APPROVAL EXPERIENCE (2022): The following adverse events are based on post-approval adverse drug experience reporting for ivermectin\u002Fpyrantel. Not all adverse events are reported to FDA\u002FCVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data.\nThe following adverse events reported in dogs are listed in decreasing order of reporting frequency:\nVomiting, diarrhea, lethargy, anorexia, seizures, ataxia, muscle tremors, hypersalivation, pruritus. In some cases, choking or intestinal obstruction has been reported after administration of\nivermectin\u002Fpyrantel.\nCONTACT INFORMATION: To report suspected adverse drug events, for technical assistance, or to obtain a copy of the Safety Data Sheet (SDS), contact Virbac AH, Inc. at 1-800-338-3659. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS, or www.fda.gov\u002Freportanimalae.",{"id":997,"kind":976,"statement":998,"species":10,"limitation":10,"source_label":375},19048,"In a field safety and effectiveness study, NexGard® PLUS was administered to dogs for the prevention of heartworm disease. The study included a total of 272 dogs (134 administered NexGard® PLUS and 138 administered active control) treated once monthly for 11 treatments. Over the 330-day study period, all observations of potential adverse reactions were recorded. The most frequent reactions reported in the NexGard® PLUS group are presented in the following table.\nTable 1. Dogs With Adverse Reactions\nClinical Sign\nNexGard® PLUS\nn = 134\nNumber (Percentage)\nActive Control\nn = 138\nNumber (Percentage)\nDiarrhea\n9 (6.7%)\n7 (5.1%)\nVomiting\n6 (4.5%)\n7 (5.1%)\nLethargy\n3 (2.2%)\n5 (3.6%)\nItching\n3 (2.2%)\n3 (2.2%)\nDermatitis\n2 (1.5%)\n1 (0.7%)\nAnorexia\n1 (0.7%)\n4 (2.9%)\nMuscle tremor\n1 (0.7%)\n1 (0.7%)\nOne dog in the NexGard® PLUS group was reported to exhibit muscle tremors along with nausea and depression for one day after the Day 0 treatment. The dog remained in the study and muscle tremors were not reported after any subsequent treatments.",{"id":1000,"kind":976,"statement":1001,"species":10,"limitation":10,"source_label":288},19049,"In clinical trials with ivermectin\u002Fpyrantel, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of ivermectin: Depression\u002Flethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.\nTo report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Virbac AH, Inc at 1-800-338-3659 or us.virbac.com. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http:\u002F\u002Fwww.fda.gov\u002Freportanimalae.",{"id":1003,"kind":976,"statement":1004,"species":10,"limitation":10,"source_label":379},19050,"Post-ApprovPost-Approval Experience: Although not all adverse reactions are reported, based on voluntary post-approval reporting, transient ataxia has been reported following the administration of Drontal Tablets for Cats and Kittens.al Experience: Although not all adverse reactions are reported, based on voluntary post-approval reporting, transient ataxia has been reported following the administration of Drontal Tablets for Cats and Kittens.",{"id":1006,"kind":976,"statement":1007,"species":10,"limitation":10,"source_label":326},19051,"Isolated incident of either vomiting, bloody stool or watery\u002Fprofuse stool have been reported following treatment. If these signs are observed and they persist, consult your veterinarian.\nQuestions? For questions or to report a suspected side effect, call Durvet, Inc. at 1-800-821-5570.\nFor additional information about reporting side effects for animal drugs, contact FDA at 1-888-FDA-VETS or http:\u002F\u002Fwww.fda.gov\u002Freportanimalae.",{"id":1009,"kind":976,"statement":1010,"species":10,"limitation":10,"source_label":322},19052,"Contact Information: To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Huvepharma, Inc. at 1-877-994-4883 or www.huvepharma.us. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http:\u002F\u002Fwww.fda.gov\u002Freportanimalae",{"id":1012,"kind":976,"statement":1013,"species":10,"limitation":10,"source_label":842},19053,"None of the 103 dogs treated with Drontal Plus Anthelmintic Tablets in the clinical field studies exhibited drug-related side effects. Of the 40 dogs treated with Drontal Plus Taste Tabs Tablets in laboratory studies, two dogs exhibited vomiting, one puppy exhibited bloody\u002Fmucoid stool and one puppy exhibited watery\u002Fprofuse stool.",{"id":1015,"kind":976,"statement":1016,"species":10,"limitation":10,"source_label":360},19054,"Post-Approval Experience: Although not all adverse reactions are reported, based on voluntary post-approval reporting, transient ataxia has been reported following the administration of Drontal Tablets for Cats and Kittens.",{"id":1018,"kind":976,"statement":1019,"species":10,"limitation":10,"source_label":330},19055,"Isolated incident of either vomiting, bloody stool or watery\u002Fprofuse stool have been reported following treatment. If these signs are observed and they persist, consult your veterinarian.",{"id":1021,"kind":976,"statement":1022,"species":10,"limitation":10,"source_label":871},19056,"Vomiting, loose stools (with or without blood) and decreased activity following treatment. If you notice these signs, contact a veterinarian.",{"id":1024,"kind":976,"statement":1025,"species":10,"limitation":10,"source_label":326},19057,"None of the 103 dogs treated with Drontal Plus Anthelmintic Tablets in the clinical field studies exhibited drug-related side effects.",{"id":1027,"kind":1028,"statement":1029,"species":10,"limitation":10,"source_label":273},19058,"mechanism_of_action","Mechanism of Action\nCredelio Quattro contains four active pharmaceutical ingredients, lotilaner, moxidectin, praziquantel, and pyrantel (as pamoate salt).\nLotilaner is an ectoparasiticide belonging to the isoxazoline group. Lotilaner inhibits insect and acarine gamma-aminobutyric acid (GABA)-gated chloride channels. This inhibition blocks the transfer of chloride ions across cell membranes, which results in uncontrolled neuromuscular activity leading to death of insects and acarines. The selective toxicity of lotilaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines’ GABA receptors versus mammalian GABA receptors.\nMoxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.\nPraziquantel’s mode of action is not precisely known, but treated tapeworms undergo muscular paralysis accompanied by a rapid influx of calcium ions and the disruption of the tegument.\nPyrantel is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, causing paralysis and death or expulsion of the parasite.\nPharmacokinetics\nDue to reduced drug bioavailability of lotilaner in the fasted state, Credelio Quattro must be administered with a meal or within 30 minutes after feeding.\nFollowing a single oral administration of Credelio Quattro at the minimum labeled dose in the fed state or a single intravenous administration of 5 mg lotilaner, 0.005 mg moxidectin, 1.25 mg praziquantel, and 1.25 mg pyrantel per kg body weight to Beagle dogs (1.5 to 2.5 years old), the mean oral bioavailability for lotilaner, praziquantel, and pyrantel was 93%, 41%, and 31%, respectively. Bioavailability for moxidectin is not reported due to insufficient data to adequately describe the elimination phase following intravenous administration. For Credelio Quattro, the area under the curve from time of dosing to the time of the last measurable concentration (AUClast) was 5970, 1.75, 1.54, and 0.857 mg*h\u002FL for lotilaner, moxidectin, praziquantel, and pyrantel, respectively. Peak concentrations (Cmax) of 9070, 15.3, 390, and 122 ng\u002FmL were reached (Tmax) 10, 4.5, 0.75, and 2.5 h after dosing for lotilaner, moxidectin, praziquantel, and pyrantel, respectively. Mean plasma elimination half‐lives were 806, 634, 3.64, and 4.87 h for lotilaner, moxidectin, praziquantel, and pyrantel, respectively.\nFollowing nine oral administrations of Credelio Quattro at 1X, 3X, and 5X the maximum labeled dose of 40 mg\u002Fkg lotilaner, 0.04 mg\u002Fkg moxidectin, 10 mg\u002Fkg praziquantel, and 10 mg\u002Fkg pyrantel, every 28 days in 8-week-old Beagle dogs, moxidectin and lotilaner area under the curve from time of dosing to the time of the last measurable concentration (AUClast) increased approximately in a less than proportional manner, whereas praziquantel AUClast increased approximately in a more than proportional manner from 1X to 5X after most study doses. Pyrantel AUClast increased approximately in a proportional manner from 1X to 5X observed after first, sixth, and last doses. Within the 1X group, accumulation was observed between Days 0 and 224 with geometric mean accumulation ratios for AUClast of 6.2 and 7.9 for lotilaner and moxidectin, respectively. Concentrations of praziquantel and pyrantel prior to each dose were below the limit of quantification.",{"id":1031,"kind":1028,"statement":1032,"species":10,"limitation":10,"source_label":375},19059,"Mode of Action:\nNexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) contains the three active pharmaceutical ingredients afoxolaner, moxidectin, and pyrantel (as pamoate salt).\nAfoxolaner is a member of the isoxazoline family, shown to bind at a binding site to inhibit insect and acarine ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and postsynaptic transfer of chloride ions across cell membranes. Prolonged afoxolaner-induced hyperexcitation results in uncontrolled activity of the central nervous system and death of insects and acarines. The selective toxicity of afoxolaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines’ GABA receptors versus mammalian GABA receptors.\nMoxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with chloride channel-mediated neurotransmission in susceptible parasites, which results in paralysis and death of the parasite.\nPyrantel is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, causing paralysis and death or expulsion of the parasite.\nPharmacokinetics:\nFollowing a single oral administration of a near-final formulation of NexGard® PLUS (at mean doses of 3.9 mg\u002Fkg afoxolaner, 18.8 mcg\u002Fkg moxidectin, and 7.8 mg\u002Fkg pyrantel pamoate) in fed and fasted Beagle dogs (10 to 21 months of age), afoxolaner and moxidectin were more rapidly absorbed in the fasted state with a time to maximum concentration (Tmax) of 2 to 3 hours. The afoxolaner mean maximum plasma concentrations (Cmax) in the fed and fasted states were 1610 and 2200 ng\u002FmL (CV=33 and 16%) and the moxidectin mean Cmax values were 11.1 and 15.5 ng\u002FmL (CV=39 and 24%), respectively. The area under the curve (AUC) for afoxolaner and moxidectin were similar between fed and fasted states. Post-dose pyrantel plasma concentrations were quantifiable out to 24 hours.\nFollowing six oral administrations of NexGard® PLUS at 1, 3, and 5X the maximum exposure dose of 5 mg\u002Fkg, 24 mcg\u002Fkg, and 10 mg\u002Fkg afoxolaner, moxidectin, and pyrantel pamoate, respectively, every 28 days in 8-week-old Beagle dogs, afoxolaner and moxidectin Tmax ranged from 2 to 6 hours. The observed mean Cmax and AUC at steady state in the 1X dose group were 2230 ng\u002FmL and 19000 days*ng\u002FmL for afoxolaner and 14.8 ng\u002FmL and 55.2 days*ng\u002FmL for moxidectin, respectively. Based on mean Cmin, afoxolaner and moxidectin accumulated by less than 4-fold at steady state. Afoxolaner and moxidectin exposure increased in a dose proportional manner between the 1X and 3X dose groups but was less than dose proportional in the 5X dose group.\nPyrantel pamoate is poorly absorbed into systemic circulation. Pyrantel pamoate is intended to remain in the gastrointestinal tract to allow effective concentrations to be delivered to gastrointestinal nematodes.",{"id":1034,"kind":1028,"statement":1035,"species":10,"limitation":10,"source_label":98},19060,"Following oral administration of SIMPARICA TRIO in Beagle dogs (13 to 15 months of age at the time of initial dosing), sarolaner and moxidectin were rapidly and well-absorbed. Following a single oral dose of SIMPARICA TRIO (sarolaner dose of 1.2 mg\u002Fkg), the sarolaner mean maximum plasma concentration (Cmax) was 523 ng\u002FmL with a mean time to maximum concentration (Tmax) of 3.5 hours and an absolute bioavailability of 88%. At a moxidectin dose of 0.024 mg\u002Fkg, the moxidectin mean Cmax was 13.1 ng\u002FmL with a mean Tmax of 2.4 hours and an absolute bioavailability of 67%.\nFollowing intravenous (IV) dosing of a combination solution of sarolaner and moxidectin, the sarolaner volume of distribution (Vss) was 2.4 L\u002Fkg and systemic clearance (CL) was 6.0 mL\u002Fkg\u002Fhr. For moxidectin the Vss was 7.65 L\u002Fkg and CL was 26.6 mL\u002Fkg\u002Fhr. The terminal half‑lives were similar after oral and IV dosing for both sarolaner (12 days) and moxidectin (11 days). The primary route of elimination of both sarolaner and moxidectin is biliary excretion with minimal metabolism.\nFollowing an oral dose of SIMPARICA TRIO containing 5 mg\u002Fkg pyrantel (as pamoate salt), pyrantel has measurable plasma concentrations, but they are low and highly variable. Pyrantel pamoate is intended to remain in the gastrointestinal tract allowing for delivery of effective concentrations to gastrointestinal nematodes.",[],[],[],[]]