[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f3m95j07a6nr5q":5},{"data":4},[],{"data":6,"error":10},{"id":7,"documentId":8,"slug":9,"name":9,"proprietary_name":10,"non_proprietary_name":10,"is_proprietary":10,"active_ingredient":10,"administration_route":10,"available_strength":10,"dosage_form":10,"dose_schedule":10,"drug_unit":10,"is_available_generically":10,"mechanism_of_action":10,"overdosage":10,"warning":10,"species":11,"citations":12,"dose_schedules":19,"available_strengths":41,"label_statements":57,"drug_classes":76,"specialties":82,"medical_conditions":83,"animal_species":84},1836,"md94zhyapy1jt1ct6k447cfb","trimeprazine",null,[],[13],{"source":14,"licence":15,"source_url":16,"harvested_by":17,"retrieved_at":18},"FDA Green Book","US public domain","https:\u002F\u002Fanimaldrugsatfda.fda.gov\u002Fadafda\u002Fapp\u002Fsearch\u002Fpublic\u002FingredientsInformationExcel\u002FSection2ActiveIngredients","load-reference-corpus.cjs","2026-09-07",[20,27,32,36],{"id":21,"dose_text":22,"species":23,"administration_route":24,"limitation":25,"source_label":26},13512,"The drug is administered orally at an initial dosage level of 1\u002F2 tablet twice daily to dogs weighing up to 10 pounds, one tablet twice daily to dogs weighing 11 to 20 pounds, two tablets twice daily to dogs weighing 21 to 40 pounds, and three tablets twice daily to dogs weighing over 40 pounds. After 4 days, the dosage is reduced to approximately 1\u002F2 the initial dosage or to an amount just sufficient to maintain remission of symptoms. Dosages in individual cases may vary and should be adjusted until proper response is obtained.","Dogs","Oral","Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.","Temaril-P® Tablets",{"id":28,"dose_text":29,"species":23,"administration_route":24,"limitation":30,"source_label":31},13513,"Up to 10 pounds body weight- 1 capsule orally once daily. 11 to 20 pounds body weight- 2 capsules orally once daily. 21 to 40 pounds body weight- 4 capsules orally once daily. Over 40 pounds body weight- 6 capsules orally once daily.","After 4 days, reduce dosage to one-half the initial dose or to an amount sufficient to maintain remission of symptoms. Dosages in individual cases may vary and should be adjusted until proper response is obtained. Do not use the drug in cases of viral infections involving corneal ulceration or dendritic ulceration of the cornea. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.","Temaril-P® Spansule Capsule No. 1",{"id":33,"dose_text":34,"species":23,"administration_route":24,"limitation":30,"source_label":35},13514,"11 to 20 pounds body weight- 1 capsule orally once daily. 21 to 40 pounds body weight- 2 capsules orally once daily. Over 40 pounds body weight- 3 capsules orally once daily.","Temaril-P® Spansule Capsule No. 2",{"id":37,"dose_text":38,"species":10,"administration_route":39,"limitation":10,"source_label":40},13515,"The same dosage schedule may be followed for both antipruritic and antitussive therapy.\nWeight of Dog\nInitial Dosage\nUp to 10 lb\n1\u002F2 tablet, twice daily\n11–20 lb\n1 tablet, twice daily\n21–40 lb\n2 tablets, twice daily\nOver 40 lb\n3 tablets, twice daily\nAfter 4 days, reduce dosage to 1\u002F2 of the initial dose or to an amount just sufficient to maintain remission of symptoms. Individual animal response will vary and dosage should be adjusted until proper response is obtained.\nStore at 20° to 25°C (68° to 77°F), excursions permitted to 40°C (104°F). Protect from light.","ORAL","Cortamine PTM (trimeprazine with prednisolone) Tablets",[42,46,49,53],{"id":43,"strength_text":44,"dosage_form":45,"proprietary_name":31,"species":23,"source_label":31},11776,"Each capsule contains 3.75 milligrams of trimeprazine in sustained released form (as the tartrate) and 1 milligram of prednisolone.","Capsule",{"id":47,"strength_text":48,"dosage_form":45,"proprietary_name":35,"species":23,"source_label":35},11777,"Each capsule contains 7.5 milligrams of trimeprazine in sustained release form (as the tartrate) and 2 milligrams of prednisolone.",{"id":50,"strength_text":51,"dosage_form":52,"proprietary_name":26,"species":23,"source_label":26},11778,"Each tablet contains 5 milligrams trimeprazine tartrate and 2 milligrams prednisolone.","Tablet",{"id":54,"strength_text":55,"dosage_form":52,"proprietary_name":56,"species":23,"source_label":56},11779,"Each tablet contains 5 mg trimeprazine as trimeprazine tartrate and 2 mg prednisolone.","Trimeprazine with Prednisolone",[58,62,65,68,71],{"id":59,"kind":60,"statement":61,"species":23,"limitation":10,"source_label":56},19813,"indication","Antipruritic: Trimeprazine with Prednisolone is recommended for the relief of itching regardless of cause. Its usefulness has been demonstrated for the relief of itching and the reduction of inflammation commonly associated with most skin disorders of dogs such as the eczema caused by internal disorders, otitis, and dermatitis (allergic, parasitic, pustular, and nonspecific). It often relieves pruritis which does not respond to other therapy.\nAntitussive: Trimeprazine with Prednisolone has been found to be effective therapy and adjunctive therapy in various cough conditions of dogs. Therefore, in addition to its antipruritic action, Trimeprazine with Prednisolone is recommended for the treatment of “kennel cough” or tracheobronchitis, bronchitis including all allergic bronchitis, and infections and coughs of nonspecific origin. (Coughs due to cardiac insufficiency would not be expected to respond to Trimeprazine with Prednisolone therapy).",{"id":63,"kind":60,"statement":64,"species":23,"limitation":25,"source_label":26},19814,"The drug is administered orally to dogs for the relief of itching regardless of cause; reduction of inflammation commonly associated with most skin disorders of dogs such as eczema, caused by internal disorders, otitis, and dermatitis, (allergic, parasitic, pustular, and nonspecific). It is also used in dogs as adjunctive therapy in various cough conditions including treatment of “kennel cough” or tracheobronchitis, bronchitis including allergic bronchitis, infections and coughs of nonspecific origin. The product may also be administered to dogs suffering from acute or chronic bacterial infections provided the infection is controlled by appropriate antibiotic or chemotherapeutic agents.",{"id":66,"kind":60,"statement":67,"species":23,"limitation":30,"source_label":31},19815,"For the relief of itching regardless of cause reduction of inflammation commonly associated with most skin disorders of dogs such as eczema caused by internal disorders, otitis, and dermatitis (allergic, parasitic, pustular and nonspecific). It is also used in dogs as adjunctive therapy in various cough conditions including treatment of \"kennel cough\" or tracheobronchitis, bronchitis including allergic bronchitis, tonsillitis, acute upper respiratory infections, and coughs of nonspecific origin. The product may also be administered to dogs suffering from acute or chronic bacterial infections, provided the infection is controlled by appropriate antibiotic or chemotherapeutic agents.",{"id":69,"kind":60,"statement":70,"species":10,"limitation":10,"source_label":40},19816,"1. Antipruritic: Cortamine P™ (trimeprazine with prednisolone) is recommended for the relief of itching regardless of cause. Its usefulness has been demonstrated for the relief of itching and the reduction of inflammation commonly associated with most skin disorders of dogs such as the eczema caused by internal disorders, otitis, and dermatitis (allergic, parasitic, pustular, and nonspecific). It often relieves pruritus which does not respond to other therapy. With any pruritus treatment, the cause should be determined and corrected; otherwise, signs are likely to recur following discontinuance of therapy.\n2. Antitussive: Cortamine P™ (trimeprazine with prednisolone) has been found to be effective therapy and adjunctive therapy in various cough conditions of dogs. Therefore, in addition to its antipruritic action, Cortamine P™ (trimeprazine with prednisolone) is recommended for the treatment of \"kennel cough\" or tracheobronchitis, bronchitis including all allergic bronchitis, and infections and coughs of nonspecific origin. (Coughs due to cardiac insufficiencies would not be expected to respond to Cortamine P™ (trimeprazine with prednisolone) therapy.) As with any antitussive treatment, the etiology of the cough should be determined and eliminated if possible. Otherwise, symptoms are likely to recur following discontinuance of therapy.\nNote: Cortamine P™ (trimeprazine with prednisolone) may be administered to animals suffering from acute or chronic bacterial infections provided the infection is controlled by appropriate antibiotic or chemotherapeutic agents.",{"id":72,"kind":73,"statement":74,"species":10,"limitation":10,"source_label":75},19817,"warning","Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Additionally, corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Corticosteroids administered to dogs during pregnancy have also resulted in other congenital anomalies, including deformed forelegs, phocomelia, and anasarca. If a vasoconstrictor is needed, norepinephrine should be used in lieu of epinephrine. Phenothiazine derivatives may reverse the usual elevating action of epinephrine causing a further lowering of blood pressure.\nKeep Trimeprazine with Prednisolone Tablets in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.","Trimeprazine with Prednisolone Tablets",[77],{"id":78,"documentId":79,"slug":80,"name":81},828,"f3t3mt2xr4xf5zzj1t19a8lk","histamine-h1-receptor-antagonists","Histamine H1 Receptor Antagonists",[],[],[]]