[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f1fwf9fdez8oh3":5},{"data":4},[],{"data":6,"error":18},{"id":7,"documentId":8,"slug":9,"title":10,"associated_anatomy":11,"differential_diagnosis":12,"epidemiology":13,"expected_prognosis":14,"pathophysiology":15,"primary_prevention":16,"sign_or_symptom":17,"medical_code":18,"species":19,"citations":24,"is_zoonotic":18,"reservoir":18,"drugs":47,"medical_tests":48,"clinical_signs":49,"animal_species":50},128,"ztqfotu3wp30psx3f6n5qgf2","colibacillosis","Colibacillosis","Air sacs, lungs, pericardium, liver capsule, yolk sac, oviduct, peritoneum, skin, joints and bone, blood; small intestine in calves","In poultry, coligranuloma lesions resemble leukosis tumours, and colisepticaemia is often compounded by viral or Mycoplasma infection that must be identified. In calves, rotavirus, coronavirus and Cryptosporidium parvum cause similar diarrhoea, but usually at 1-3 weeks of age, whereas K99 E. coli typically strikes in the first four days of life.","Avian colibacillosis affects chickens, turkeys, ducks and other birds and is a leading cause of poultry losses worldwide. It often follows infectious bronchitis, Newcastle disease, avian influenza or Mycoplasma infection, or poor housing: ammonia damages airway cilia and inhaled faecal dust is a confirmed route. Contaminated feed, water and eggs spread it, and vertical transmission from breeders is documented. Resistance to almost all antibiotic classes, including colistin and carbapenems, has been reported, and some APEC share virulence genes with human extraintestinal E. coli, raising possible zoonotic concern. In calves, K99 E. coli is one of the four most important causes of neonatal diarrhoea worldwide, typically at 1-4 days old.","Poultry mortality reaches up to 20% overall and up to 53.5% in young chicks; coligranuloma spreading through a flock can kill up to 75%. Antimicrobial resistance often makes treatment fail. Neonatal calf diarrhoea has a case fatality risk of about 4.9%.","Colibacillosis is disease caused by pathogenic Escherichia coli. In poultry the agent is avian pathogenic E. coli (APEC), an extraintestinal pathotype that can live harmlessly in the gut and airways and invades through damaged tracheal or intestinal lining when birds are stressed. Fimbrial adhesins (type 1, P and S), siderophore iron-uptake systems, and protective capsule, outer membrane proteins and lipopolysaccharide let it resist complement and phagocytes and spread through the blood, causing airsacculitis, perihepatitis, pericarditis and septicaemia. In newborn calves, E. coli carrying the K99 (F5) adhesin attaches to the intestinal mucosa and produces enterotoxin, leading to watery diarrhoea, dehydration and electrolyte imbalance.","Poultry: good litter and ventilation to limit ammonia and dust, clean chlorinated water, egg fumigation soon after laying, control of predisposing infections, commercial live or inactivated vaccines. Calves: colostrum management and dam vaccination.","In poultry: rising mortality, weight loss and falling egg production, with fibrinous airsacculitis, pericarditis and perihepatitis at necropsy. Other forms include yolk-sac infection with chick deaths, salpingitis and peritonitis in hens, cellulitis, swollen head syndrome, arthritis and osteomyelitis, and coligranulomas in liver, duodenum, caecum and mesentery. In calves aged 1-4 days: watery diarrhoea with dehydration, acidosis and electrolyte imbalance; calves that are depressed, anorexic and febrile often have E. coli septicaemia.",null,[20,21,22,23],"Chickens","Turkeys","Ducks","Cattle",[25,32,37,42],{"claims":26,"source":27,"licence":28,"source_url":29,"harvested_by":30,"retrieved_at":31},"pathophysiology (APEC virulence factors, routes), epidemiology (hosts, predisposing infections, resistance, zoonotic potential), sign_or_symptom (disease forms), expected_prognosis (20%, 53.5%), primary_prevention (vaccines, litter and air quality)","Pathogens (2021): Avian Pathogenic Escherichia coli (APEC): An Overview of Virulence and Pathogenesis Factors, Zoonotic Potential, and Control Strategies, Kathayat et al. (via Europe PMC, PMC8069529)","Creative Commons Attribution (CC BY) 4.0","https:\u002F\u002Fwww.ebi.ac.uk\u002Feuropepmc\u002Fwebservices\u002Frest\u002FPMC8069529\u002FfullTextXML","load-reference-corpus.cjs","2026-09-17",{"claims":33,"source":34,"licence":35,"source_url":36,"harvested_by":30,"retrieved_at":31},"epidemiology (ammonia, faecal dust, eggs, vertical transmission), sign_or_symptom (salpingitis, coligranuloma), differential_diagnosis (leukosis-like lesions), expected_prognosis (coligranuloma up to 75%), primary_prevention (ventilation, chlorination, egg fumigation)","Veterinary World (2024): Avian pathogenic Escherichia coli: Epidemiology, virulence and pathogenesis, diagnosis, pathophysiology, transmission, vaccination, and control, Khairullah et al.","Creative Commons Attribution 4.0 International License","https:\u002F\u002Fwww.veterinaryworld.org\u002FVol.17\u002FDecember-2024\u002F6.pdf",{"claims":38,"source":39,"licence":40,"source_url":41,"harvested_by":30,"retrieved_at":31},"epidemiology and differential_diagnosis (four enteropathogens and their ages), sign_or_symptom (calves, septicaemia), expected_prognosis (4.9%), primary_prevention (colostrum, dam vaccination)","Acta Veterinaria Scandinavica (2014): Advances in prevention and therapy of neonatal dairy calf diarrhoea, Meganck et al. (via Europe PMC, PMC4246539)","Creative Commons Attribution License (CC BY 4.0)","https:\u002F\u002Fwww.ebi.ac.uk\u002Feuropepmc\u002Fwebservices\u002Frest\u002FPMC4246539\u002FfullTextXML",{"claims":43,"source":44,"licence":45,"source_url":46,"harvested_by":30,"retrieved_at":31},"pathophysiology (K99 adhesion to mucosa, enterotoxin, watery diarrhoea, dehydration, electrolyte imbalance)","The Veterinary Quarterly (2026): Microbiota-bile acid-host axis dysregulation drives enteropathogenesis in Escherichia coli K99-induced neonatal calf diarrhea (via Europe PMC, PMC12862847)","CC BY-NC 4.0","https:\u002F\u002Fwww.ebi.ac.uk\u002Feuropepmc\u002Fwebservices\u002Frest\u002FPMC12862847\u002FfullTextXML",[],[],[],[51,55,60,65],{"id":52,"documentId":53,"slug":54,"name_en":23,"name_ar":18},777,"h9lqv8yrfatdtq0hbnxk1jug","cattle",{"id":56,"documentId":57,"slug":58,"name_en":59,"name_ar":18},1403,"dgben1yiycmxxdqxeyusr75f","duck","Duck",{"id":61,"documentId":62,"slug":63,"name_en":64,"name_ar":18},1427,"nxuraoydsn1ul47omwk4ofrt","chicken","Chicken",{"id":66,"documentId":67,"slug":68,"name_en":69,"name_ar":18},1430,"ksk50vgfsax1lvsijnx29stb","turkey","Turkey"]