[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"notifications-list":3,"$f3oc5sh01dwbka":5},{"data":4},[],{"data":6,"error":18},{"id":7,"documentId":8,"slug":9,"title":10,"associated_anatomy":11,"differential_diagnosis":12,"epidemiology":13,"expected_prognosis":14,"pathophysiology":15,"primary_prevention":16,"sign_or_symptom":17,"medical_code":18,"species":19,"citations":25,"is_zoonotic":18,"reservoir":18,"drugs":38,"medical_tests":39,"clinical_signs":40,"animal_species":41},203,"awrb4lxyjro88tuar0xybqsj","infectious-bursal-disease-gumboro-disease","Infectious bursal disease (Gumboro disease)","Bursa of Fabricius, immune system (B lymphocytes), skeletal muscle (breast and thigh), proventriculus, kidneys, cloaca","Newcastle disease, chicken infectious anaemia and nephropathogenic infectious bronchitis also cause sudden deaths with haemorrhages or kidney lesions in young chickens; early bursal swelling and haemorrhage point to Gumboro. Marek's disease, inclusion body hepatitis, aflatoxicosis, stress and recent IBD vaccination can also alter the bursa. Normal bursal involution occurs gradually from about 6 weeks to sexual maturity.","Chickens, turkeys, ducks, guinea fowl, pheasants and ostriches can be infected, but only chickens develop disease, usually when younger than 10 weeks and most severely at 3 to 6 weeks; infection before 3 weeks is usually subclinical but immunosuppressive. Serotype 2 infects turkeys, ducks and chickens without signs. Very virulent serotype 1 strains are common worldwide, and antigenic variants exist. The virus is highly contagious, passes in faeces and moves between houses on fomites; it is very stable in the environment and hard to remove from premises, so infection spreads quickly through a flock. It has no reported zoonotic potential.","No treatment exists. Survivors recover within about a week but may stay immunosuppressed. Mortality is under 40% with classical strains and over 60% with very virulent strains (MSD), and is higher in layer breeds than broilers.","Gumboro disease is caused by infectious bursal disease virus, a non-enveloped, double-stranded RNA virus of the genus Avibirnavirus (family Birnaviridae). Serotype 1 replicates in the bursa of Fabricius, where it destroys immature B lymphocytes and depletes the lymphoid tissue. In the acute phase the bursa becomes oedematous and haemorrhagic within about four days and then atrophies. Loss of B cells suppresses antibody responses, severely and for a long time when infection occurs in the first two weeks of life, so birds succumb to secondary infections with organisms that are normally harmless. Acute cases also show haemorrhage in the thigh and breast muscles and proventriculus, with nephritis.","Vaccinate breeders (live then inactivated) so chicks get maternal antibodies; give chicks live vaccine once maternal antibodies wane, or recombinant or immune-complex vaccine in ovo or at hatch; clean and disinfect houses thoroughly.","In acute outbreaks in 3- to 6-week-old chickens, sudden deaths appear alongside severe prostration, incoordination, watery diarrhoea, soiled vent feathers, vent pecking and an inflamed cloaca. Morbidity is typically close to 100%, and survivors recover within about a week. Subclinical infection in younger chicks may show only as bursal atrophy and secondary infections. At necropsy the bursa of Fabricius is swollen, oedematous, with yellowish transudate and haemorrhages early, then shrunken; breast and leg muscles and the proventriculus may be haemorrhagic, and kidneys show nephritis.",null,[20,21,22,23,24],"Chickens","Turkeys","Ducks","Guinea fowl","Ostriches",[26,33],{"claims":27,"source":28,"licence":29,"source_url":30,"harvested_by":31,"retrieved_at":32},"agent, host range, age susceptibility, bursal lymphoid depletion and immunosuppression, lesions, differential diagnosis (ND, CIA, nephropathogenic IBV), very virulent strains worldwide, serotype 2, no zoonotic potential, vaccination strategies","WOAH Terrestrial Manual 2024, Chapter 3.3.12 Infectious bursal disease (Gumboro disease)","(c) WOAH, free to consult","https:\u002F\u002Fwww.woah.org\u002Ffileadmin\u002FHome\u002Feng\u002FHealth_standards\u002Ftahm\u002F3.03.12_IBD.pdf","load-reference-corpus.cjs","2026-09-17",{"claims":34,"source":35,"licence":36,"source_url":37,"harvested_by":31,"retrieved_at":32},"confirms dsRNA agent, B-cell destruction, clinical signs, morbidity, mortality by strain, lesions, differentials (Marek's, inclusion body hepatitis, aflatoxicosis, involution), no treatment, environmental stability, vaccine types","MSD Veterinary Manual - Infectious Bursal Disease in Poultry (confirmation only)","not stated on source page","https:\u002F\u002Fwww.merckvetmanual.com\u002Fpoultry\u002Finfectious-bursal-disease\u002Finfectious-bursal-disease-in-poultry",[],[],[],[42,47,52,57,61],{"id":43,"documentId":44,"slug":45,"name_en":46,"name_ar":18},1403,"dgben1yiycmxxdqxeyusr75f","duck","Duck",{"id":48,"documentId":49,"slug":50,"name_en":51,"name_ar":18},1427,"nxuraoydsn1ul47omwk4ofrt","chicken","Chicken",{"id":53,"documentId":54,"slug":55,"name_en":56,"name_ar":18},1430,"ksk50vgfsax1lvsijnx29stb","turkey","Turkey",{"id":58,"documentId":59,"slug":60,"name_en":23,"name_ar":18},1436,"dyscl3cijv9r5339nag4v16n","guinea-fowl",{"id":62,"documentId":63,"slug":64,"name_en":65,"name_ar":18},1444,"kkeriab9ehvhlgpw8adfpotk","ostrich","Ostrich"]