coumaphos

Chickens (laying)

For control of capillary worm (Capillaria obsignata) and as an aid in control of common round worm (Ascaridia galli) and cecal worm (Heterakis gallinae).

In Type C feed. Administer continuously as the total feed ration for 14 days. When reinfection occurs, treatment may be repeated but not sooner than 3 weeks after the end of the previous treatment. Do not feed to chickens within 10 days of vaccination or other conditions of stress. Treatment of colored breeds of commercial layers should be avoided while in production since these breeds appear to be more sensitive to coumaphos than white breeds. As sole medication; medications in general should be avoided while birds are approaching peak production. Such interruption of normal feeding practices may upset the flock and lower egg production. Diagnosis by competent personnel is essential. Flock condition and production records should be carefully evaluated prior to treatment. Adequate directions and warnings for use must be given and shall include a statement that coumaphos is a cholinesterase inhibitor and that animals being treated with coumaphos should not be exposed during or within a few days before or after treatment to any other cholinesterase-inhibiting drugs, insecticides, pesticides, or chemicals.

Meldane 2

Chickens (replacement pullets)

For control of capillary worm (Capillaria obsignata) and as an aid in control of common round worm (Ascaridia galli) and cecal worm (Heterakis gallinae).

In Type C feed. Administer before the onset of production. Diagnosis by competent personnel is essential. Administer continuously as total feed ration for from 10 to 14 days. Do not feed to chickens under 8 weeks of age nor within 10 days of vaccination or other conditions of stress. If birds are maintained on contaminated litter or exposed to infected birds, a second 10 to 14 day treatment is recommended but not sooner than 3 weeks after the end of the previous treatment. As sole medication. If occurs after production begins, repeat treatment as recommended for laying flocks. Adequate directions and warnings for use must be given and shall include a statement that coumaphos is a cholinesterase inhibitor and that animals being treated with coumaphos should not be exposed during or within a few days before or after treatment to any other cholinesterase-inhibiting drugs, insecticides, pesticides, or chemicals.

Meldane 2

Cattle (beef and dairy)

Control of gastrointestinal roundworms (Haemonchus spp., Ostertagia spp., Cooperia species, Nematodirus spp., Trichostrongylus spp.)

Feed 0.0002 pounds (0.091 gram) per 100 pounds body weight per day for 6 consecutive days in the normal grain ration to which the animals are accustomed but not in rations containing more than 0.1 percent coumapho. Do not feed to animals less than 3 months old. Do not feed to sick animals or animals under stress, such as those just shipped, dehorned, castrated, or weaned within the last 3 weeks. Do not feed in conjunction with oral drenches or with feeds containing phenothiazine. Should conditions warrant repeat treatment at 30-day intervals. Adequate directions and warnings for use must be given and shall include a statement that coumaphos is a cholinesterase inhibitor and that animals being treated with coumaphos should not be exposed during or within a few days before or after treatment to any other cholinesterase-inhibiting drugs, insecticides, pesticides, or chemicals.

Purina® 6 Day Worm-Kill Concentrate

Sulfonamides are contraindicated in animals that are hypersensitive to them and in animals with severe renal or hepatic impairment.

DailyMed 1e688687-7c0d-449d-8367-163eafe724f3

Not for use in humans. Keep out of reach of children. WARNING: May be fatal if swallowed. May be fatal if inhaled. Harmful if absorbed through skin. Causes moderate eye irritation. Do not breathe dust. Avoid contact with eyes, skin, or clothing. To avoid overexposure, each individual person cannot treat more than 3 large wounds (>2 inches diameter) a day or more than 30 small superficial wounds (≤2 inches diameter) a day (or an equivalent thereof) with Negasunt Powder or any other coumaphos-containing product. Wear all required personal protective equipment (PPE) when handling and applying this product. Only protected handlers may be in the area during application. Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Do not apply in a confined, non-ventilated area. Provide thorough ventilation. Respirator fit testing, medical qualification, and training Using a program that conforms to OSHA's requirements (see 29 CFR Part 1910.134), employers must verify that any handler who uses a respirator is: •fit-tested and fit-checked, •trained, and •examined by a qualified medical practitioner to ensure physical ability to safely wear the style of respirator to be worn. A qualified medical practitioner is a physician or other licensed health care professional who will evaluate the ability of a worker to wear a respirator. The initial evaluation consists of a questionnaire that asks about medical conditions (such as a heart condition) that would be problematic for respirator use. If concerns are identified, then additional evaluations, such as a physical exam, might be necessary. The initial evaluation must be done before respirator use begins. Handlers must be reexamined by a qualified medical practitioner if their health status or respirator style or use conditions change. Upon request by local/state/federal/tribal enforcement personnel, employers must provide documentation demonstrating how they have complied with these requirements. Personal Protective Equipment Applicators and other exposed persons must wear: •coveralls worn over long-sleeve shirt and long pants, •shoes and socks, •protective eyewear, •chemical-resistant gloves made of barrier laminate, butyl rubber (≥ 14 mils), nitrile rubber (≥14 mils), neoprene rubber (>14 mils), natural rubber (≥14 mils), polyethylene, polyvinyl chloride (PVC) (≥14 mils), or Viton (>14 mils), and •a minimum of a NIOSH-approved elastomeric half mask respirator consisting of protection factor (PF) 10 fitted with organic vapor (OV) cartridges and combination R or P filters; OR a NIOSH-approved gas mask with OV canisters; OR a NIOSH-approved powered air purifying respirator with OV cartridges and combination HE filters. Remove PPE immediately if product gets inside. Then wash thoroughly and put on clean clothing. Remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing. Wash hands thoroughly before eating, drinking, chewing gum, using tobacco, or using the toilet. Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry. Discard clothing and other materials heavily contaminated with this product's dust. Do not reuse them. FIRST AID If Swallowed: •Call a poison control center or doctor immediately for treatment advice. •Have the person sip a glass of water if able to swallow. •Do not induce vomiting unless told to do so by the poison control center or doctor. •Do not give anything by mouth to an unconscious person. If Inhaled: •Move person to fresh air. •If person is not breathing, call 911 or an ambulance, then give artificial respiration, preferably mouth-to-mouth, if possible. •Call a poison control center or doctor for further treatment advice. If on skin or clothing: •Take off contaminated clothing. •Rinse skin immediately with plenty of water for 15–20 minutes. •Call a poison control center or doctor for treatment advice. If in eyes: •Hold eye open and rinse slowly and gently with water for 15–20 minutes. •Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. •Call a poison control center or doctor for treatment advice. Contains an organophosphate that inhibits cholinesterase. Have the product container or label with you when calling a poison control center or doctor or going for treatment. If you need immediate medical attention, call the Poison Control Center at 1-800-222-1222 or a doctor. Note To Physician: Atropine sulfate by injection is antidotal. Pralidoxime chloride (2-PAM) is also antidotal and may be administered in conjunction with atropine. Sulfanilamide, the antibiotic in Negasunt Powder, can cause allergic reactions in sensitized individuals, which can include skin rash, hives, and itching. More severe reactions, while rare, can occur, including anaphylactic reactions, blood dyscrasias, severe cutaneous reactions, gastrointestinal reactions, hepatitis and hepatocellular necrosis, central nervous system (CNS) reactions, and toxic nephrosis. At the first sign of hypersensitivity, skin rash or other reactions, the user should discontinue exposure to Negasunt Powder. To obtain Safety Data Sheets (SDS), contact Elanco Product & Veterinary Support at 1-800-428-4441 or visit https://www.elanco.com/us/elanco-safety-data-sheets.

DailyMed 1e688687-7c0d-449d-8367-163eafe724f3

Withdrawal Periods and Residue Warnings Treated animals must not be slaughtered for human consumption within 28 days of the last treatment. A milk discard time has not been established for this product; do not use in animals producing milk for human consumption. A withdrawal period has not been established for this product in pre-ruminating calves; treated calves and calves born to treated cows must not be processed for veal.

DailyMed 1e688687-7c0d-449d-8367-163eafe724f3

For external use only on animals. Do not apply directly to areas such as waterers, feed troughs, or mangers. Do not contaminate water, feed, troughs, feed handling equipment, or milk or meat handling equipment. Use with caution in very young, weak, or debilitated animals. Overuse may increase the risk of adverse events. In the case of overdose, treat with atropine sulfate or 2-PAM as soon as possible.

DailyMed 1e688687-7c0d-449d-8367-163eafe724f3

Clinical signs in veterinary species associated with organophosphate and carbamate toxicity include frequent urination and defecation, muscle twitching, and watering eyes, followed by salivation, diarrhea, vomiting, and muscle weakness. This can proceed to anorexia, miosis or mydriasis, dyspnea, and bradycardia or tachycardia, and can also include more rapid involuntary muscle twitching and scattered fasciculations, followed by severe weakness and paralysis.

DailyMed 1e688687-7c0d-449d-8367-163eafe724f3

Chickens (laying)

Coumaphos 27.2 grams per ton of feed (0.003 percent).

Oral

In Type C feed. Administer continuously as the total feed ration for 14 days. When reinfection occurs, treatment may be repeated but not sooner than 3 weeks after the end of the previous treatment. Do not feed to chickens within 10 days of vaccination or other conditions of stress. Treatment of colored breeds of commercial layers should be avoided while in production since these breeds appear to be more sensitive to coumaphos than white breeds. As sole medication; medications in general should be avoided while birds are approaching peak production. Such interruption of normal feeding practices may upset the flock and lower egg production. Diagnosis by competent personnel is essential. Flock condition and production records should be carefully evaluated prior to treatment. Adequate directions and warnings for use must be given and shall include a statement that coumaphos is a cholinesterase inhibitor and that animals being treated with coumaphos should not be exposed during or within a few days before or after treatment to any other cholinesterase-inhibiting drugs, insecticides, pesticides, or chemicals.

Meldane 2

Chickens (replacement pullets)

Coumaphos 36.3 grams per ton of feed (0.004 percent).

Oral

In Type C feed. Administer before the onset of production. Diagnosis by competent personnel is essential. Administer continuously as total feed ration for from 10 to 14 days. Do not feed to chickens under 8 weeks of age nor within 10 days of vaccination or other conditions of stress. If birds are maintained on contaminated litter or exposed to infected birds, a second 10 to 14 day treatment is recommended but not sooner than 3 weeks after the end of the previous treatment. As sole medication. If occurs after production begins, repeat treatment as recommended for laying flocks. Adequate directions and warnings for use must be given and shall include a statement that coumaphos is a cholinesterase inhibitor and that animals being treated with coumaphos should not be exposed during or within a few days before or after treatment to any other cholinesterase-inhibiting drugs, insecticides, pesticides, or chemicals.

Meldane 2

Cattle (beef and dairy)

Coumaphos, 0.0002 pound (0.091 gram) per 100 pounds of body weight per day.

Oral

Feed 0.0002 pounds (0.091 gram) per 100 pound body weight per day for 6 consecutive days in the normal grain ration to which the animals are accustomed but not in rations containing more than 0.1 percent coumaphos. Do not feed to animals less than 3 months old. Do not feed to sick animals or animals under stress, such as those just shipped, dehorned, castrated, or weaned within the last 3 weeks. Do not feed in conjunction with oral drenches or with feeds containing phenothiazine. Should conditions warrant repeat treatment at 30-day intervals. Adequate directions and warnings for use must be given and shall include a statement that coumaphos is a cholinesterase inhibitor and that animals being treated with coumaphos should not be exposed during or within a few days before or after treatment to any other cholinesterase-inhibiting drugs, insecticides, pesticides, or chemicals.

Purina® 6 Day Worm-Kill Feed

Apply topically to sufficiently cover the open wound. Application every 2 to 3 days may be needed for larger superficial or deep wounds. Apply until granulation tissue has formed and evidence of healing is apparent.

TOPICAL

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