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For the treatment of Giardia duodenalis infection in dogs.

AYRADIA™

Diagnostic Chart Gill and Skin Flukes: Very common fish parasites. Can be found on the gills, scales or skin. Not visible without the aid of magnification. Symptoms may include: darkening of skin, clamped fins, excess mucous. Fish may also swim erratically or become emaciated. Hole-in-the-Head Disease: Symptoms include pitting and erosion of skin and muscle tissue around the face and side of body. Many infected fish exhibit poor appetite, weight loss and nervousness. Wasting Disease: Fish parasites transmitted fromn fish to fish cause emaciation, anemia and lethargy.Tissue damage leading to subsequent ulceration of the gastrointestinal tract. Excess mucus and white stringy feces are often produced as a result of parasitic invasion. Swollen Abdomen: Fish infected with tapeworms (cestodes), often have an extended or swollen abdomen. Internal area of attachment results in damaged tissue. Fish normally show signs of reduction ingrowth and general malaise. Treatment Tips Quarantine aquarium. Remove any dead fish immediately. Do not remove or add any live fish to the infected aquarium. Parasitic infections are highly contagious and can spread to other aquariums by nets, algae scrapers and wet hands. To speed up the life cycle of parasites and shorten treatment period, raise water temperature to 82 F (28 C). To aid osmoreregulation and ease stress of infected fish, add 1 tablespoon of API AQUARIUM SALT for each 5 gallons (19 L) of aquarium water, or 1 -1/4 cup for each 100 gallons (378 L). This medication may be used in combination with API antibacterial medications, including API MELAFIX, to help prevent scondary bacterial infection.

Drug Label

Diagnostic Chart Gill and Skin Flukes: Very common fish parasite. Can be found on the gills, scales or skin. Not visible without the aid of magnification. Symptoms may include: darkening of skin, clamped fins, excess mucous. Fish may also swim erratically or become emaciated. Hole-in-the-Head Disease: Symptoms include pitting and erosion of skin and muscle tissue around the face and side of body. Many infected fish exhibit poor appetite, weight loss and nervousness. Wasting Disease: Fish parasites transmitted from fish to fish cause emaciation, anemia and lethargy. Tissue damage leading to subsequent ulceration of the gastrointestinal tract. Excess mucus and white stringy feces are often produced as a result of parasitic invasion. Swollen Abdomen: Fish infected with tapeworms (cestodes), often have an extended or swollen abdomen. Internal areas of attachment results in damaged tissue. Fish normally show signs of reduction in growth and general malaise.

Drug Label

Common Symptoms of Parasitic Diseases. ICK: Small white spots may cover the entire body; fish may rub or scratch against bottom PROTOZOAN VLVET: Tiny yellowish spots loss of color, rubbing or scratching on bottom EXTERNAL PARASITES: Extra mucous, visible spots or worms, rapid breathing, flashing, scratching or rubbing on rocks

MetroCleanse

MetroPlex™ is an effective and safe treatment for several protozoan and anaerobic bacterial diseases of fish (Cryptocaryon, Hexamita, Ichthyophthirius). It does not adversely affect the filter bed and is easily removed with carbon. There is little danger of overdosing.

Metroplex™

AYRADIA oral suspension is indicated for the treatment of Giardia duodenalis infection in dogs.

AYRADIA (metronidazole oral suspension) for dogs

Mechanism of Action Metronidazole is a nitroimidazole compound known to exert antiprotozoal and antibacterial activity. Metronidazole has antiprotozoal activity against Giardia duodenalis. The mechanism of action for its antiprotozoal activity is not well understood but it acts primarily against the trophozoite forms of the parasites resulting in a decrease in cyst shedding. Metronidazole is reduced as it enters the susceptible target cell where it interacts with bacterial or protozoal DNA, causing a loss of helical structure and strand breakage in the DNA. This breakage leads to the inhibition of nucleic acid synthesis and therefore causes death of the bacterial or protozoal cell.

AYRADIA (metronidazole oral suspension) for dogs

The use of this drug is contraindicated in animals with a history of a hypersensitivity to nitroimidazole compounds, including metronidazole.

AYRADIA (metronidazole oral suspension) for dogs

User Safety Warnings Keep out of reach of children. Not for use in humans. Metronidazole has been found to cause cancer in laboratory animals; however, there is inadequate evidence of carcinogenicity in humans. People with known sensitivity to metronidazole or other nitroimidazole derivatives should avoid contact with AYRADIA oral suspension. This product is not a dermal or eye irritant but is a skin sensitizer which can potentially cause allergic contact dermatitis. Wash hands after use. Avoid contact with skin. In case of skin contact, wash the affected area thoroughly. Persons who come in contact with the dog’s saliva during the first five minutes after administration should wash their hands. If the drug has been applied to dog food, the dog food should be kept away from children until after the dog has finished eating. Avoid accidental ingestion. In case of accidental ingestion, seek medical advice immediately. Animal Safety Warnings Federal law prohibits the extra-label use of this drug in food-producing animals. Keep AYRADIA oral suspension in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.

AYRADIA (metronidazole oral suspension) for dogs

KEEP OUT OF THE REACH OF CHILDREN. For aquarium use only. Not for human consumption or for the treatment of fish intended for human consumption. Avoid contact with skin and eyes. May cause irritation. ! WARNING: This product can expose you to chemicals including Metronidazole, which is known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Drug Label

THIS PRODUCT IS INTENDED FOR THE EXCLUSIVE USE WITH ORNAMENTAL ORGANISMS INDICATED AND IS NOT INTENDED FOR USE WITH OTHER ANIMALS, HUMANS, OR FISH FOR HUMAN CONSUMPTION

MetroCleanse

This product contains chemicals, including Metronidazole, which is known to the State of California to cause cancer.

MetroCleanse

For use in ornamental aquariums only. Not for human consumption.

Metroplex™

In a clinical field effectiveness and safety study, 120 dogs were treated with AYRADIA oral suspension and 60 dogs were treated with a vehicle control. The most frequently reported adverse reactions were diarrhea (6.7% treated, 5% vehicle) and vomiting (4.2% treated, 3.3% vehicle). One dog treated with AYRADIA oral suspension was reported to have hyperactivity while being treated. The safety of AYRADIA oral suspension was also evaluated in a masked, active-controlled, multi-site field study, to evaluate the effectiveness of AYRADIA oral suspension for the treatment of Giardia spp. in dogs. Enrollment included 180 client-owned dogs diagnosed with Giardia spp. infection; 91 dogs were treated with AYRADIA oral suspension at 25 mg/kg twice daily for 5 consecutive days and 89 were treated with an active control. The dogs were 7.8 weeks to 13.4 years old, various pure or mixed breeds, and intact or neutered male dogs or intact or spayed female dogs. The most frequently reported adverse reactions in dogs treated with AYRADIA oral suspension were vomiting (14.3%) and diarrhea (3.3%). Other less frequently reported (<1.2%) adverse reactions included hypersalivation, abdominal pain, polydipsia and polyuria, anorexia, otitis externa, and lethargy. Contact Information To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Virbac AH, Inc. at 1-800-338-3659 or us.virbac.com. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae

AYRADIA (metronidazole oral suspension) for dogs

25 mg/kg (11.3 mg/lb) of body weight, using the supplied syringe, twice daily for five consecutive days

Oral

AYRADIA™

Shake vigorously before use. AYRADIA oral suspension is administered orally at a dose of 25 mg/kg (11.3 mg/lb) of body weight, using the supplied syringe, twice daily for five consecutive days. Each line on the included dosing syringe represents 0.1 mL of oral suspension. For dogs weighing more than 15 kg (33 lb), the total dose volume will be divided over multiple syringe draws because the dosing syringe only holds up to 3 mL. Alternatively, a standard luer lock syringe that holds more than 3 mL can also be used. The flavored suspension can be administered directly into the mouth or in a small amount of food (see Instructions for Using the Dispensing System and Preparing a Dose of AYRADIA oral suspension on reverse side).

ORAL

AYRADIA (metronidazole oral suspension) for dogs

Broadcast Instructions: Remove all invertebrates prior to dosing if using broadcast method. Use 1 packet of MetroCleanse mixed per tablespoon of normal food (adding some water if food is dry). Feed medicated food mix daily until symptoms disappear or up to three weeks. Refrigerate or freeze leftover mix between dosing/feeding. No adjustment of filtration needed when used with food. MetroCleanse can easily be removed from system by adding carbon. MetroCleanse is effective against internal and external infections regardless of dosing method.

EXTRACORPOREAL

MetroCleanse

Directions for Use: For best results, remove activated carbon or filter cartridge from filter and continue aeration. For each 20 gallons (75 L) of water add 1 scoop (1 tsp.). For larger systems, for each 240 gallons (908 L) of water add 12 scoops (4 Tbsp.). or for each 960 gallons (3,634 L) of water add one cup. Repeat dose after 48 hours. Wait another 48 hours then change 25% of the aquarium water and add API BIO CHEM ZORB, fresh activated carbon or replace filter cartridge. Will not discolor water. Safe for use with live plants

TOPICAL

Drug Label

Directions for Use: For best results, remove activated carbon or filter cartridge from filter and continue aeration. For each 10 gallons (38 L) of water, empty one packet directly into aquarium. Repeat dose after 48 hours. Wait another 48 hours then change 25% of the aquarium water and add fresh activated carbon or replace filter cartridge. This package treats up to 100 gallons. Two doses required for full course of treatment. Will not discolor water Safe for use with live plants.

TOPICAL

Drug Label

DIRECTIONS: Use 1-2 measures (included) for every 40 L (10 US gallons). Repeat every 2 days for up to 3 weeks or until symptoms disappear. Turn off UV, ozone, and chemical filtration. To feed, blend 1 measure with about 1 tablespoon of frozen food paste. To minimize loss during feeding use with Focus™. To enhance palatability use with GarlicGuard™ or Entice™. Food may be refrozen.

ORAL

Metroplex™