نيكاربازين

Chickens (broilers)

To aid in preventing outbreaks of cecal (Eimeria tenella) and intestinal (E. acervulina, E. maxima, E. necatrix, and E. brunetti) coccidiosis in broiler chickens and for increased rate of weight gain and improved feed efficiency.

Feed continuously as sole ration from the time chicks are placed on the litter until past the time when coccidiosis is ordinarily a hazard. Do not use as a treatment for coccidiosis. Do not use in flushing mashes. Do not feed to laying hens. Withdraw 4 days prior to slaughter.

BMD® / Nicarmix 25®

Chickens (broilers)

Aid in preventing outbreaks of cecal (Eimeria tenella) and intestinal (E. acervulina, E. maxima, E. necatrix and E. brunetti) coccidiosis; for increased rate of weight gain.

Feed continuously as sole ration from the time chicks are placed on the litter until past the time when coccidiosis is ordinarily a hazard. Do not use as a treatment for coccidiosis. Do not use in flushing mashes. Do not feed to laying hens. Withdraw 4 days before slaughter.

Lincomix® / Nicarmix 25®

Chickens (broilers)

For the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati, and E. maxima.

Maxiban™ 72

Broiler Chickens

For the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati; and as an aid in the prevention of necrotic enteritis caused or complicated by Clostridium spp. or other organisms susceptible to bacitracin methylene disalicylate

Feed as the sole ration.Do not allow adult turkeys, horses or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Nicarbazin medicated broilers may show reduced heat tolerance if exposed to high temperature and high humidity. Provide adequate drinking water and ventilation during these periods. For broiler chickens only. Do not feed to laying chickens. Not for use in feeds for breeder chickens.

BMD® / Maxiban®

Broiler Chickens

For the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati, and for increased rate of weight gain, improved feed efficiency, and improved pigmentation in broiler chickens.

Feed continuously as sole ration. Withdraw 5 days before slaughter. Do not allow turkeys, horses or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Do not feed to laying hens. Use as sole source of organic arsenic.

3-Nitro® / BMD® / Maxiban®

Broiler Chickens

As an aid in preventing outbreaks of cecal (Eimeria tenella) and intestinal (E. acervulina, E. maxima, E. necatrix, and E. brunetti) coccidiosis, and for increased rate of weight gain and improved feed efficiency in broiler chickens.

Do not feed to laying hens in production. Do not use as a treatment for outbreaks of coccidiosis. Broiler chickens fed nicarbazin may show reduced heat tolerance when exposed to high temperature and high humidity to which they have not been accustomed and under severe conditions, fatalities may result. An ample supply of drinking water and adequate ventilation will improve the birds’ tolerance of heat.

Nicarb® / Baciferm®

Broiler Chickens

For the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunette, and E. mivati, and for increased rate of weight gain and improved feed efficiency.

Feed continuously as the sole ration. For broiler chickens only. Nicarbazin medicated broiler chickens may show reduced heat tolerance when exposed to high temperature and high ambient humidity. Provide adequate drinking water and ventilation during these periods. Do not allow adult turkeys, horses, or other equines access to formulations containing narasin. Ingestion of narasin by these animals has been fatal. Do not feed to laying hens. Withdraw 5 days before slaughter.

Flavomycin® / Maxiban®

As an aid in preventing outbreaks of cecal (Eimeria tenella) and intestinal (E. acervulina, E. maxima, E. necatrix, and E. brunetti) coccidiosis, and for increased rate of weight gain, improved feed efficiency, and improved pigmentation.

Feed continuously as sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard; do not use as a treatment for outbreaks of coccidiosis. As a sole source of organic arsenic; drug overdose or lack of water may result in leg weakness. Do not use in flushing mashes. Do not feed to chickens producing eggs for human consumption.

Nicarbazin® plus PENICILLIN G PROCAINE plus 3-Nitro®

Aid in preventing outbreaks of cecal (Eimeria tenella) and intestinal (E. acervulina, E. maxima, E. necatrix and E. brunetti) coccidiosis.

Feed continuously as sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard. Do not use as a treatment for coccidiosis. Do not use in flushing mashes. Do not feed to laying hens. Withdraw 4 days before slaughter.

Nicarmix 25®

Chickens (Broilers)

As an aid in preventing outbreaks of cecal (Eimeria tenella) and intestinal (E. acervulina, E. maxima, E. necatrix, and E. brunetti) coccidiosis and as an aid in prevention of necrotic enteritis caused or complicated by Clostridium spp. or other organisms susceptible to bacitracin methylenedisalicylate in broiler chickens.

Feed as the sole ration from the time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard. Do not use as a treatment for coccidiosis. Do not use in flushing mashes. If losses exceed 0.5 percent in a 2-day period, obtain an accurate diagnosis and follow the instructions of your veterinarian or poultry pathologist. Broiler chickens fed feed medicated with nicarbazin may show reduced heat tolerance when exposed to high temperature and high humidity to which they have not been accustomed and under severe conditions, fatalities may result. An ample supply of drinking water and adequate ventilation will improve the birds’ tolerance of heat.

Nicarb® and BMD®

Chickens (Broilers)

As an aid in preventing outbreaks of cecal (Eimeria tenella) and intestinal (E. acervulina, E. maxima, E. necatrix and E. brunetti) coccidiosis and for increased rate of weight gain and improved feed efficiency in broiler chickens.

Feed as the sole ration from the time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard. Do not use as a treatment for coccidiosis. Do not use in flushing mashes. If losses exceed 0.5 percent in a 2-day period, obtain an accurate diagnosis and follow the instructions of your veterinarian or poultry pathologist. Broiler chickens fed feed medicated with nicarbazin may show reduced heat tolerance when exposed to high temperature and high humidity to which they have not been accustomed and under severe conditions, fatalities may result. An ample supply of drinking water and adequate ventilation will improve the birds’ tolerance of heat.

Nicarb® and BMD®

Broiler chickens

For the prevention of mortality caused by necrotic enteritis associated with Clostridium perfringens; and for the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati, and E. maxima in broiler chickens.

Feed as the sole ration for 21 consecutive days. Feed to chickens that are at risk of developing, but not yet showing clinical signs of, necrotic enteritis associated with Clostridium perfringens in broiler chickens. To assure responsible antimicrobial drug use in broiler chickens, treatment administration must begin on or before 18 days of age. The safety of avilamycin has not been established in chickens intended for breeding purposes. Avilamycin has not been demonstrated to be effective in broiler chickens showing clinical signs of necrotic enteritis prior to the start of medication. Nicarbazin medicated broilers may show reduced heat tolerance if exposed to high temperature and high humidity. Provide adequate drinking water and ventilation during these periods. Do not allow adult turkeys, horses or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Do not feed to laying hens. Narasin and nicarbazin may only be sourced from Maxiban™, NADA #138-952, which provides these drugs at a 1:1 ratio.

Inteprity™ and Maxiban™

Broiler chickens

For prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin and for the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati, and E. maxima in broiler chickens.

Stafac® and Maxiban™

Broiler chickens

For increased rate of weight gain and improved feed efficiency, and for the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati, and E. maxima in broiler chickens.

Pennitracin MD® and Maxiban™

Mézclese completamente las siguientes cantidades de Maxiban 72 en una tonelada de alimento completo para proporcionar de 27 a 45 g/tonelada corta (30 a 50 g/Ton Métrica), tanto de narasina como de nicarbazina. La dosis debe ajustarse de acuerdo con la gravedad del desafío por coccidias, el cual varía según las condiciones ambientales y de manejo. Se debe realizar una premezcla de Maxiban 72 en 15-20 lb de alimento antes de incorporar al total de alimento terminado. Narasina + Nicarbazina (Gramos por Tonelada) Maxiban 72 (Libras por tonelada en el alimento medicado tipo C) 27 Narasina and 27 Nicarbazina 0.75 36 Narasina and 36 Nicarbazina 1.00 45 Narasina and 45 Nicarbazina 1.25 Ejemplo de alimento medicado tipo B: Cantidad de artículo medicado tipo A necesaria para fabricar una tonelada de alimento medicado tipo B. La concentración máxima permitida para el alimento medicado tipo B es de 11,350 g/ton cada una de narasina y nicarbazina. Libras de Maxiban 72 a añadir por tonelada para preparer alimento medicado de tipo B Concentración resultante de narasina y nicarbazina en el alimento medicado tipo B g/ton (para cada medicamento) g/lb (para cada medicamento) 27.56 992.2 0.50 55.12 1,984.3 0.99 110.24 3,968.6 1.98

FDA application 138-952

As an aid in preventing outbreaks of cecal (Eimeria tenella) and intestinal (E. acervulina, E. maxima, E. necatrix,and E. brunetti) coccidiosis in chickens.

Nicarb® 25% (Nicarbazin) TYPE A MEDICATED ARTICLE WITH MICROTRACER®

Administre continuamente como ración única.

FDA application 138-952

Período de retiro: no se requiere ningún período de retiro. Advertencia de seguridad para el usuario: Deberá usarse ropa protectora, guantes impermeables y mascarilla antipolvo al mezclar o manipular el producto. Los operadores deberán lavarse cuidadosamente con agua y jabón después de manejar el producto. Si se produce contacto accidental con los ojos, lavar inmediatamente con agua abundante. No usar en seres humanos. ¿Tiene preguntas o comentarios? Para obtener asistencia técnica o informar efectos secundarios, comuníquese con Elanco US Inc. al 1-800-428-4441. Para obtener información adicional sobre la notificación de efectos secundarios de medicamentos en animales, comuníquese con la Administración de Alimentos y Medicamentos (Food and Drug Administration, FDA) al 1-888-FDA-VETS o en http://www.fda.gov/reportanimalae.

FDA application 138-952

Withdrawal Period: No withdrawal period is required. User Safety Warning: When mixing and handling Maxiban 72, use protective clothing, impervious gloves, and a dust mask. Operators should wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. Not for human use. Questions/Comments? For technical assistance or to report side effects, contact Elanco US Inc. at 1-800-428-4441. For additional information about reporting side effects for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae.

FDA application 138-952

Do not feed to laying chickens. Do not use as a treatment for outbreaks of coccidiosis. Do not use in flushing mashes. If losses exceed 0.5 percent in a 2-day period, obtain an accurate diagnosis and follow the instructions of your veterinarian or poultry pathologist. Broilers fed feed medicated with NICARB 25% may show reduced heat tolerance when exposed to high temperature and high humidity to which they have not been accustomed and under severe conditions, fatalities may result. An ample supply of drinking water and adequate ventilation will improve the birds’ tolerance of heat.

Nicarb® 25% (Nicarbazin) TYPE A MEDICATED ARTICLE WITH MICROTRACER®

Withdraw 4 days before slaughter when used at levels ≤ 0.0125%. Withdraw 5 days before slaughter when used at levels >0.0125% Keep this and all drugs out of the reach of children. NOT FOR HUMAN USE RESTRICTED DRUG (CALIFORNIA) – USE ONLY AS DIRECTED

Nicarb® 25% (Nicarbazin) TYPE A MEDICATED ARTICLE WITH MICROTRACER®

Chickens (broilers)

Nicarbazin 113.5 g/ton (0.0125 percent) in combination with bacitracin zinc (30 g/ton). Feed continuously as the sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard.

Oral

Do not feed to laying hens in production. Do not use as a treatment for outbreaks of coccidiosis.

Albac® 50 plus Nicarb®

Chickens (broilers)

Narasin 27 to 45 grams per ton of feed, plus nicarbazin, 27 to 45 grams per ton of feed in a 1:1 ratio in the Type B and C medicated feeds Feed continuously as the sole ration. Do not feed to laying hens.

Oral

Maxiban™ 72

Chickens (broilers)

113.5 (0.0125 percent) grams nicarbazin per ton of feed in combination with roxarsone 22.7 (0.0025 percent) grams per ton of feed, plus lincomycin, 2 (0.0004 percent) grams per ton of feed.

Oral

Feed continuously as sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard. As sole source of organic arsenic. Do not use a treatment for coccidiosis. Do not use in flushing mashes. Do not feed to laying hens. Withdraw 5 days before slaughter.

3-Nitro® / Lincomix® / Nicarmix 25®

Chickens (broilers)

113.5 (0.0125 percent) grams Nicarbazin per ton of feed in combination with Roxarsone 22.7 (0.0025 percent) grams per ton of feed.

Oral

Feed continuously as sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard. As sole source of organic arsenic. Do not use a treatment for coccidiosis. Do not use in flushing mashes. Do not feed to laying hens. Withdraw 5 days before slaughter.

Nicarbazin Roxarsone Premix

Chickens (broilers)

113.5 (0.0125 percent) grams Nicarbazin per ton of feed in combination with Lincomycin 2 (0.00044 percent) grams per ton of feed.

Oral

Feed continuously as sole ration from the time chicks are placed on the litter until past the time when coccidiosis is ordinarily a hazard. Do not use as a treatment for coccidiosis. Do not use in flushing mashes. Do not feed to laying hens. Withdraw 4 days before slaughter.

Nicarbazin Lincomycin Premix

Chickens (broilers)

Nicarbazin 113.5 grams per ton with bacitracin methlyene disalicylate 30 in grams per ton of feed.

Oral

Feed continuously as sole ration from the time chicks are placed on the litter until past the time when coccidiosis is ordinarily a hazard. Do not use as a treatment for coccidiosis. Do not use in flushing mashes. Do not feed to laying hens. Withdraw 4 days prior to slaughter.

BMD® / Nicarmix 25®

Broiler Chickens

27 to 45 grams Nicarbazin per ton of feed in combination with Narasin, 27 to 45 grams per ton of feed and bacitracin methylene disalicylate, 4 to 50 grams per ton of feed.

Oral

For broiler chickens only. Do not feed to laying hens. Withdraw 5 days before slaughter. Do not allow adult turkeys, horses or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Nicarbazin medicated broilers may show reduced heat tolerance if exposed to high temperature and high humidity. Provide adequate drinking water and ventilation during these periods.

BMD® / Maxiban®

Broiler Chickens

27 to 45 grams Nicarbazin per ton of feed, 50 grams bacitracin methylene disalicylate per ton of feed, and 22.7 to 45.4 grams roxarsone per ton of feed.

Oral

Feed continuously as sole ration. Withdraw 5 days before slaughter. Do not allow turkeys, horses or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Do not feed to laying hens. Use as sole source of organic arsenic.

3-Nitro® / BMD® / Maxiban®

Broiler Chickens

90.8 to 181.6 (0.01 to 0.02 percent) grams nicarbazin per ton of feed with 30 grams bacitracin methylene disalicylate per ton of feed.

Oral

Feed continuously as sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard. Do not use as a treatment for coccidiosis. Do not use in flushing mashes. Do not feed to laying hens.

Nicarbazin / Bacitracin Premix

Broiler Chickens

27 to 45 grams Nicarbazin per ton of feed in combination with Narasin 27 to 45 grams per ton and Lincomycin 2 to 4 grams per ton.

Oral

Feed continuously as sole ration. Withdraw 5 days before slaughter. For broiler chickens only. Not for use in layers, breeders, or turkeys. Do not allow adult turkeys, horses or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Nicarbazin medicated broilers may show reduced heat tolerance if exposed to high temperature and high humidity. Provide adequate drinking water and ventilation during these periods. Do not allow rabbits, hamster, guinea pigs, horses or ruminants access to feeds containing lincomycin. Ingestion by these species may result in severe gastrointestinal effects.

Lincomix® / Maxiban®

Broiler Chickens

113.5 (0.0125 percent) grams nicarbazin per ton of feed in combination with bacitracin zinc 4 - 50 grams per ton of feed.

Oral

Do not feed to laying hens in production. Do not use as a treatment for outbreaks of coccidiosis. Broiler chickens fed nicarbazin may show reduced heat tolerance when exposed to high temperature and high humidity to which they have not been accustomed and under severe conditions, fatalities may result. An ample supply of drinking water and adequate ventilation will improve the birds’ tolerance of heat.

Nicarb® / Baciferm®

Broiler Chickens

113.5 (0.0125 percent) grams Nicarbazin per ton of feed in combination with bambermycins 1 to 2 grams per ton.

Oral

Feed continuously as sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard. Do not use as a treatment for coccidiosis. Do not use in flushing mashes. Do not feed to laying hens. Withdraw 4 days before slaughter

Nicarbazin (NICARB®) plus Bambermycins (FLAVOMYCIN®)

Broiler Chickens

Narasin, 27 to 45 grams per ton; nicarbazin, 27 to 45 grams per ton; and bambermycins, 1 to 2 grams per ton.

Oral

Feed continuously as the sole ration. For broiler chickens only. Nicarbazin medicated broiler chickens may show reduced heat tolerance when exposed to high temperature and high ambient humidity. Provide adequate drinking water and ventilation during these periods. Do not allow adult turkeys, horses, or other equines access to formulations containing narasin. Ingestion of narasin by these animals has been fatal. Do not feed to laying hens. Withdraw 5 days before slaughter.

Flavomycin® / Maxiban®

Broiler Chickens

Narasin: 27-45 g/ton Nicarbazin: 27-45 g/ton Bacitracin methylene disalicylate: 100-200 g/ton

Oral

Feed as the sole ration. To control necrotic enteritis, start this feed at first clinical signs of disease; vary bacitracin dosage based on severity of infection; administer continuously for 5-7 days or as long as clinical signs persist, then reduce bacitracin to prevention level (50 g/ton).Do not allow adult turkeys, horses or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Nicarbazin medicated broilers may show reduced heat tolerance if exposed to high temperature and high humidity. Provide adequate drinking water and ventilation during these periods. For broiler chickens only. Do not feed to laying chickens. Not for use in feeds for breeder chickens. Consult a poultry diagnostic laboratory or pathologist to determine the diagnosis and advice regarding the optimal level of drug.

BMD® / Maxiban®

Broiler Chickens

27 to 45 grams Nicarbazin per ton of feed, and 22.7 to 45.4 grams roxarsone per ton of feed.

Oral

Feed continuously as sole ration. Withdraw 5 days before slaughter. Do not allow turkeys, horses or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Do not feed to laying hens. Use as sole source of organic arsenic.

3-Nitro® / Maxiban®

Nicarbazin 90.8 to 181.6 g/ton, procaine penicillin 2.4 to 50 g/ton, roxarsone 22.7 to 45.4 g/ton

Oral

Feed continuously as sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard; do not use as a treatment for outbreaks of coccidiosis. As a sole source of organic arsenic; drug overdose or lack of water may result in leg weakness. Do not use in flushing mashes. Do not feed to chickens producing eggs for human consumption.

Nicarbazin® plus PENICILLIN G PROCAINE plus 3-Nitro®

Nicarbazin 90.8 to 181.6 g/ton, procaine penicillin 2.4 to 50 g/ton

Oral

Feed continuously as sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard; do not use as a treatment for outbreaks of coccidiosis. Do not use in flushing mashes. Do not feed to chickens producing eggs for human consumption. Discontinue medication 4 d before marketing the birds for human consumption to allow for elimination of the drug from edible tissue.

Nicarbazin® plus PENICILLIN G PROCAINE

90.8-181.6 (0.01-0.02%) grams nicarbazin per ton of feed.

Oral

Feed continuously as sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard. Do not use as a treatment for coccidiosis. Do not use in flushing mashes. Do not feed to laying hens.

Nicarb® 25%

113.5 (0.0125 percent) grams Nicarbazin per ton of feed.

Oral

Feed continuously as sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard. Do not use as a treatment for coccidiosis. Do not use in flushing mashes. Do not feed to laying hens. Withdraw 4 days before slaughter.

Nicarmix 25®

Chickens (Broilers)

90.8 to 181.6 grams nicarbazin per ton of feed with 4 - 50 grams bacitracin methylenedisalicylate per ton of feed.

Oral

Feed as the sole ration from the time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard. Do not use as a treatment for coccidiosis. Do not use in flushing mashes. If losses exceed 0.5 percent in a 2-day period, obtain an accurate diagnosis and follow the instructions of your veterinarian or poultry pathologist. Broiler chickens fed feed medicated with nicarbazin may show reduced heat tolerance when exposed to high temperature and high humidity to which they have not been accustomed and under severe conditions, fatalities may result. An ample supply of drinking water and adequate ventilation will improve the birds’ tolerance of heat.

Nicarb® and BMD®

Broiler chickens

20 g/ton of virginiamycin (as Stafac®) and 54 to 90 g/ton of narasin and nicarbazin (as Maxiban™; 27 to 45 g/ton narasin and 27 to 45 g/ton nicarbazin, in a 1:1 ratio to create 54 to 90 g/ton). Feed as the sole ration.

Oral

Stafac® and Maxiban™

Broiler chickens

4 to 50 g/ton of bacitracin (as feed grade bacitracin methylenedisalicylate provided by Pennitracin MD®) and 27 to 45 g/ton each of narasin and nicarbazin (as Maxiban™)

Oral

Pennitracin MD® and Maxiban™

Broiler chickens

13.6 to 40.9 grams per ton avilamycin, 27 to 45 grams per ton narasin, and 27 to 45 grams nicarbazin per ton of Type C medicated feed.

Oral

Feed as the sole ration for 21 consecutive days. Feed to chickens that are at risk of developing, but not yet showing clinical signs of, necrotic enteritis associated with Clostridium perfringens in broiler chickens. To assure responsible antimicrobial drug use in broiler chickens, treatment administration must begin on or before 18 days of age. The safety of avilamycin has not been established in chickens intended for breeding purposes. Avilamycin has not been demonstrated to be effective in broiler chickens showing clinical signs of necrotic enteritis prior to the start of medication. Nicarbazin medicated broilers may show reduced heat tolerance if exposed to high temperature and high humidity. Provide adequate drinking water and ventilation during these periods. Do not allow adult turkeys, horses or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Do not feed to laying hens. Narasin and nicarbazin may only be sourced from Maxiban™, NADA #138-952, which provides these drugs at a 1:1 ratio.

Inteprity™ and Maxiban™

Thoroughly mix the following amounts of Maxiban 72 in one ton of complete feed to provide from 27 to 45 grams per ton each of narasin and nicarbazin. The dosage should be adjusted to meet the severity of the coccidial challenge, which varies with environmental and management conditions. A preblend of the Maxiban 72 in 15-20 lbs of feed should be made before incorporating into the total amount of finished feed. Narasin and Nicarbazin (Grams Per Ton) Maxiban 72 (Pounds Per Ton of Type C Medicated Feed) 27 Narasin and 27 Nicarbazin 0.75 36 Narasin and 36 Nicarbazin 1.00 45 Narasin and 45 Nicarbazin 1.25 Example of Type B medicated feed – Amounts of Type A medicated article necessary to manufacture one ton of Type B medicated feed. The maximum permitted Type B medicated feed concentration is 11,350 g/ton each of narasin and nicarbazin. Pounds of Maxiban 72 to Add Per Ton to Make a Type B Medicated Feed Resulting Narasin and Nicarbazin Concentration in the Type B Medicated Feed g/ton (for each drug) g/lb (for each drug) 27.56 992.2 0.50 55.12 1,984.3 0.99 110.24 3,968.6 1.98

ORAL

FDA application 138-952

NICARB (nicarbazin) 25% should be thoroughly and evenly mixed in the feed in accordance with current good manufacturing practice for feed. Type C medicated feeds should contain 0.01 – 0.02% nicarbazin. Uniformly mix 0.8 – 1.6 pounds of Nicarb 25% with one of the feed ingredients to make at least 10 pounds of premix before final mixing. Mix the resulting premix with feed to make 1 ton (2000 lb) of finished feed containing 0.01 – 0.02% nicarbazin. SUGGESTED DIRECTIONS FOR FEED TAGS Use Directions Use Nicarbazin Type C medicated feed as the only ration from the time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard.

ORAL

Nicarb® 25% (Nicarbazin) TYPE A MEDICATED ARTICLE WITH MICROTRACER®

Feed continuously as the sole ration.

ORAL

FDA application 138-952