tiamulin

For the control of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin and for treatment of swine bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis sensitive to chlortetracycline and treatment of bacterial pneumonia caused by Pasteurella multocida sensitive to chlortetracycline.

Feed continuously as sole ration for 14 days. Use asonly source of chlortetracycline. Use as sole source of tiamulin. Do not feed to animals other than swine. The effects of tiamulin on swine reproductive performance, pregnancy and lactation have not been determined. Swine being treated with tiamulin should not have access to feeds containing polyether ionophores (e.g., lasalocid, monensin, narasin, salinomycin, and semduramycin) as adverse reactions may occur. If signs of toxicity occur, discontinue use of medicated feed. Withdraw medicated feed 2 days before slaughter.

Denagard® plus CTC

For the treatment of swine bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis sensitive to chlortetracycline and treatment of bacterial pneumonia caused by Pasteurella multocida sensitive to chlortetracycline.

Denagard® and Deracin®

For the treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin.

Prepare fresh water daily. Use as only source of drinking water. Do not allow consumption of feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin, and semduramicin) as adverse reactions may occur. The effects of tiamulin on swine reproductive performance, pregnancy, and lactation have not been determined.

Denagard™ 12.5%

For control of porcine proliferative enteropathies (ileitis) associated with Lawsonia intracellularis.

Feed continuously as the sole ration for not less than 10 days.

Denagard™ 80% Coated

For the treatment of swine pneumonia due to Actinobacillus pleuropneumoniae susceptible to tiamulin.

Prepare fresh water daily. Use as only source of drinking water. Do not allow consumption of feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin, and semduramicin) as adverse reactions may occur. The effects of tiamulin on swine reproductive performance, pregnancy, and lactation have not been determined.

Denagard™ 12.5%

For treatment of swine dysentery associated with Treponema hyodysenteriae susceptible to tiamulin.

Use for 5 consecutive days. Withdraw 3 days before slaughter. Prepare fresh water daily. Not for use in swine over 250 pounds body weight. Use as only source of drinking water.

TiaGard™

For treatment of swine dysentery associated with Brachyspira hyodysenteriae.

Use for 5 consecutive days. Withdraw medication 3 days before slaughter. Prepare fresh water daily. Not for use in swine over 250 pounds body weight. Use as only source of drinking water. Do not allow consumption of feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, or salinomycin) as adverse reactions may occur.

Tiagard™

Directions for using Vetmulin In medicated proportioners: One liter of Vetmulin Liquid Concentrate mixed with water to make 4.3 gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 227 mg of tiamulin hydrogen fumarate per gallon to 550 gallons of drinking water for treatment of swine dysentery. Three liters of Vetmulin Liquid Concentrate mixed with water to make 4.3 gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 681 mg tiamulin hydrogen fumarate per gallon to a total of 550 gallons of drinking water for treatment of swine pneumonia. In barrels or tanks: One liter (1000 mL) of Vetmulin Liquid Concentrate will medicate 550 gallons of drinking water at 227 mg per gallon for treatment of swine dysentery or 183 gallons at 681 mg per gallon for treatment of swine pneumonia. Measure Vetmulin Liquid Concentrate carefully, pour into the proper amount of water and thoroughly mix. The concentration of tiamulin hydrogen fumarate in the stock solution and in the drinking water delivered must be adjusted to compensate for variation in water consumption by pigs due to body weight, environmental and other factors. It is important that the pigs receive the proper drug dose of 3.5 mg of tiamulin hydrogen fumarate per pound of body weight daily for 5 consecutive days for treatment of swine dysentery or a dose of 10.5 mg per pound body weight daily for 5 consecutive days for treatment of swine pneumonia. Attention: If no response to treatment is obtained within 5 days re-establish the diagnosis. Failure of response may be related to the presence of non-susceptible organisms of other complicating disease conditions. Because of the tendency for the disease to recur on premises with a history of swine dysentery or with swine pneumonia, a control program should be implemented after treatment. Drugs are not substitutes for proper sanitary measures or good management, but should be used in conjunction with such practices.

Vetmulin® 12.5%(tiamulin hydrogen fumarate)

Directions for preparing Vetmulin medicated solutions Determine the amount of Vetmulin Liquid Concentrate needed to medicate the desired volume of drinking water at the proper concentration. Carefully measure out this amount, add it to the water and stir to thoroughly mix. 1. Prepare fresh medicated drinking water every day for the 5 day treatment period. 2. Water medicated with Vetmulin should be the only source of drinking water during the treatment period. *3. Increase or decrease dilution rate as required to obtain proper daily drug dose. Number of pigs this bottle will treat for ONE day based on water consumption per pig One Liter Net tiamulin hydrogen fumarate content: 125,000 mg Diseases to be treated: Swine Dysentery Swine Pneumonia Daily tiamulin hydrogen fumarate required per pound body weight: 3.5 mg 10.5 mg Required treatment duration: 5 days 5 days Pig Wt, lb Water Intake, gal # of Pigs # of Pigs 20 0.3 - 0.5 1,786 595 45 0.4 - 1.1 794 265 75 0.7 - 1.5 476 159 125 1.0 - 2.0 286 95 180 1.2 - 3.0 198 66 Suggested final dilution of: 1 bottle (1 Liter) 550 gal 183 gal 3 bottles (3 Liters) 1650 gal 550 gal 1/2 bottle (0.5 Liters) 275 gal 92 gal Tiamulin hydrogen fumarate concentration per gallon at suggested final dilution* 227 mg 681 mg (60 ppm) (180 ppm)

Vetmulin® 12.5%(tiamulin hydrogen fumarate)

One Liter Liquid Concentrate Indications: Treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae and swine pneumonia due to Actinobacillus pleuropneumoniae, susceptible to tiamulin. Use Directions: Do not use undiluted. This bottle contains 125,000 mg tiamulin hydrogen fumarate for use in preparing medicated drinking water for swine. See package insert for complete directions; read completely. Five Liter Liquid Concentrate Indications: Denagard (tiamulin hydrogen fumarate), when administered in the drinking water for five consecutive days, is an effective antibiotic for the treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin at a dose level of 3.5 mg tiamulin hydrogen fumarate per pound of body weight daily and for treatment of swine pneumonia due to Actinobacillus pleuropneumoniae susceptible to tiamulin when given at 10.5 mg tiamulin hydrogen fumarate per pound of body weight daily. Use Directions: Do not use undiluted. This bottle contains 625,000 mg tiamulin hydrogen fumarate for use in preparing medicated drinking water for swine. See package insert for complete directions; read completely.

Denagard™ 12.5% (tiamulin hydrogen fumarate)

Determine the amount of TiaGard 12.5% Liquid Concentrate needed to medicate the desired volume of drinking water at the proper concentration. Carefully measure out this amount, add it to the water and stir to thoroughly mix. 1. Prepare fresh medicated drinking water every day for the 5 day treatment period. 2. Water medicated with TiaGard 12.5% should be the only source of drinking water during the treatment period. *3. Increase or decrease dilution rate as required to obtain proper daily drug dose. Number of pigs this bottle will treat for ONE day based on water consumption per pig One Liter Net tiamulin hydrogen fumarate content: 125,000 mg Diseases to be treated: Swine Dysentery Swine Pneumonia Daily tiamulin hydrogen fumarate required per pound body weight: 3.5 mg 10.5 mg Required treatment duration: 5 days 5 days Pig Wt, lb Water Intake, gal # of pigs # of pigs 20 0.3 - 0.5 1,786 595 45 0.4 - 1.1 794 265 75 0.7 - 1.5 476 159 125 1.0 - 2.0 286 95 180 1.2 - 3.0 198 66 Suggested final dilution of: 1 bottle (1 Liter) 550 gal 183 gal 3 bottles (3 Liters) 1650 gal 550 gal 1/2 bottle (0.5 Liters) 275 gal 92 gal Tiamulin hydrogen fumarate concentration per gallon at suggested final dilution* 227 mg 681 mg (60 ppm) (180 ppm)

TiaGard® 12.5%(tiamulin hydrogen fumarate)

Triamulox, when administered in the drinking water for five consecutive days, is an effective antibiotic for the treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin at a dose level of 3.5 mg tiamulin hydrogen fumarate per pound of body weight daily and for treatment of swine pneumonia due to Actinobacillus pleuropneumoniae susceptible to tiamulin when given at 10.5 mg tiamulin hydrogen fumarate per pound of body weight daily. Contraindications: Swine being treated with Triamulox should not have access to feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin and semduramicin) as adverse reactions may occur.

TriamuloxLiquid Concentrate

Indications: Vetmulin (tiamulin hydrogen fumarate), when administered in the drinking water for five consecutive days, is an effective antibiotic for the treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin at a dose level of 3.5 mg tiamulin hydrogen fumarate per pound of body weight daily and for treatment of swine pneumonia due to Actinobacillus pleuropneumoniae susceptible to tiamulin when given at 10.5 mg tiamulin hydrogen fumarate per pound of body weight daily.

Vetmulin® 12.5%(tiamulin hydrogen fumarate)

For treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to Tiamulin; For control of porcine proliferative enteropathies (ileitis) associated with Lawsonia intracellularis; For control of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to Tiamulin.

Net Weight: 55 lb (25 kg) Denagard™ 80%

Indications: Treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae and swine pneumonia due to Actinobacillus pleuropneumoniae, susceptible to tiamulin.

Vetmulin® 12.5%(tiamulin hydrogen fumarate)

Contraindications: Swine being treated with Vetmulin (tiamulin hydrogen fumarate) should not have access to feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin and semduramicin) as adverse reactions may occur.

Vetmulin® 12.5%(tiamulin hydrogen fumarate)

Swine being treated with TiaGard 12.5% (tiamulin hydrgen fumarate) should not have access to feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin and semduramicin) as adverse reactions may occur.

TiaGard® 12.5%(tiamulin hydrogen fumarate)

Keep out of reach of children. Avoid contact with skin. Direct contact with skin or mucous membranes may cause irritation. Residue Warning: Withdraw medicated water 3 days before slaughter after treatment at 3.5 mg per pound and 7 days before slaughter following treatment at 10.5 mg per pound body weight. Caution: For use in drinking water of swine only - Not for use in humans. Prepare fresh medicated water daily. Use as the only source of drinking water for 5 days. The effects of tiamulin on swine reproductive performance, pregnancy and lactation have not been determined. Adverse Reactions: Overdoses of Triamulox have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. If signs of toxicity occur, discontinue use of medicated water and replace with clean, fresh water. In rare cases, redness of the skin primarily over the ham and underline has been observed during medication. If these signs appear, discontinue use of this drug. Provide ample clean drinking water. Thoroughly rinse (hose down) the housing to remove urine and feces from animal contact surfaces or move the animals to clean pens. If the condition persists, consult your veterinarian. Studies to evaluate the safety of the water soluble form of tiamulin in breeding swine have not been done.

TriamuloxLiquid Concentrate

Denagard 10 Type B Medicated Swine Feed label contains residue information for use in swine. Keep out of reach of children. lrritating to eyes and respiratory system. May cause sensitization by inhalation and skin contact. Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing and gloves. Caution: Do not feed undiluted. Do not use in feeds for animals other than swine. The effects of tiamulin on swine reproductive performance, pregnancy and lactation have not been determined. Swine being treated with Denagard (tiamulin) should not have access to feeds containing polyether ionophores (e.g., lasalocid, monensin, narasin, salinomycin and semduramicin) as adverse reactions may occur. If signs of toxicity occur, discontinue use.

Net Weight: 55 lb (25 kg) Denagard™ 80%

Use Directions: Do not use undiluted. This bottle contains 125,000 mg tiamulin hydrogen fumarate for use in preparing medicated drinking water for swine. See package insert for complete directions; read completely.

Vetmulin® 12.5%(tiamulin hydrogen fumarate)

Prepare fresh medicated water daily. Use as the only source of drinking water for 5 days. The effects of tiamulin on swine reproductive performance, pregnancy and lactation have not been determined.

TiaGard® 12.5%(tiamulin hydrogen fumarate)

Residue Warnings: Withdraw medicated water 3 days before slaughter after treatment at 3.5 mg per pound body weight and 7 days before slaughter after treatment at 10.5 mg per pound body weight.

Vetmulin® 12.5%(tiamulin hydrogen fumarate)

Withdraw medicated water 3 days before slaughter after treatment at 3.5 mg per pound and 7 days before slaughter following treatment at 10.5 mg per pound body weight.

TiaGard® 12.5%(tiamulin hydrogen fumarate)

Warning: Keep out of reach of children. Avoid direct contact with the skin. Direct contact with skin or mucous membranes may cause irritation.

Vetmulin® 12.5%(tiamulin hydrogen fumarate)

Adverse Reactions: Overdoses of 12.5% tiamulin hydrogen fumarate have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. If signs of toxicity occur, discontinue use of medicated water and replace with clean, fresh water. In rare cases, redness of the skin primarily over the ham and underline has been observed during medication. If these signs appear, discontinue use of this drug. Provide ample clean drinking water. Thoroughly rinse (hose down) the housing to remove urine and feces from animal contact surfaces or move the animals to clean pens. If the condition persists, consult your veterinarian. Studies to evaluate the safety of the water soluble form of tiamulin in breeding swine have not been done.

Vetmulin® 12.5%(tiamulin hydrogen fumarate)

Overdoses of Denagard have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. If signs of toxicity occur, discontinue use of medicated water and replace with clean, fresh water. In rare cases, redness of the skin primarily over the ham and underline has been observed during medication. If these signs appear, discontinue use of this drug. Provide ample clean drinking water. Thoroughly rinse (hose down) the housing to remove urine and feces from animal contact surfaces or move the animals to clean pens. If the condition persists, consult your veterinarian. Studies to evaluate the safety of the water soluble form of tiamulin in breeding swine have not been done.

Denagard™ 12.5% (tiamulin hydrogen fumarate)

To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet, contact Huvepharma Inc. at 1-877-994-4883 or www.huvepharma.us. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/ reportanimalae.

Vetmulin® 12.5%(tiamulin hydrogen fumarate)

35 grams of tiamulin (as tiamulin hydrogen fumarate), plus the equivalent of approximately 400 grams of chlortetracycline hydrochloride varying with body weight and feed consumption to provide 10 milligrams of chlortetracycline per pound of body weight daily

Oral

Feed continuously as sole ration for 14 days as only source of chlortetracycline. As chlortetracycline calcium complex, Type A medicated articles containing the equivalent of 50 to 100 grams per pound of chlortetracycline hydrochloride. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Pennchlor™ / Denagard®

35 grams of tiamulin hydrogen fumarate and approximately 400 grams chlortetracycline (varying with body weight and feed consumption to provide 10 milligrams of chlortetracycline per pound of body weight daily) per ton of Type C medicated feed.

Oral

Feed continuously as sole ration for 14 days. Use asonly source of chlortetracycline. Use as sole source of tiamulin. Do not feed to animals other than swine. The effects of tiamulin on swine reproductive performance, pregnancy and lactation have not been determined. Swine being treated with tiamulin should not have access to feeds containing polyether ionophores (e.g., lasalocid, monensin, narasin, salinomycin, and semduramycin) as adverse reactions may occur. If signs of toxicity occur, discontinue use of medicated feed. Withdraw medicated feed 2 days before slaughter.

Denagard® plus CTC

Administer in drinking water for five consecutive days at a dose level of 10.5 mg tiamulin hydrogen fumarate per pound body weight daily.

Oral, in drinking water

BimaGard™ 12.5%

Administer 10.5 mg tiamulin hydrogen fumarate per pound of body weight daily in drinking water for five consecutive days.

Oral, in drinking water

TiaGard™ 12.5%

Approximately 400g/ton of Deracin® in finished Type C medicated feed. Feed continuously as the sole ration for 14 days.

Oral

Denagard® and Deracin®

Administer 10.5 milligrams of tiamulin per pound of body weight daily in drinking water for 5 consecutive days.

Oral

Prepare fresh water daily. Use as only source of drinking water. Do not allow consumption of feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin, and semduramicin) as adverse reactions may occur. The effects of tiamulin on swine reproductive performance, pregnancy, and lactation have not been determined.

Denagard™ 12.5%

35g/ton of Denagard® in finished Type C medicated feed. Feed continuously as the sole ration for 14 days.

Oral

Denagard® and Deracin®

10.5 milligrams of tiamulin per pound of body weight for 5 days.

Oral

Use for 5 consecutive days. Withdraw 7 days before slaughter. Prepare fresh water daily. Not for use in swine over 250 pounds body weight. Use as only source of drinking water. Do not allow consumption of feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, or salinomycin) as adverse reactions may occur.

TiaGard™

3.5 milligrams of tiamulin per pound of body weight daily.

Oral

Use for 5 consecutive days. Withdraw medication 3 days before slaughter. Prepare fresh water daily. Not for use in swine over 250 pounds body weight. Use as only source of drinking water. Do not allow consumption of feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, or salinomycin) as adverse reactions may occur.

Tiagard™

200 g tiamulin/ton of feed

Oral

Feed continuously as sole ration for 14 consecutive days.

Denagard™ 80% Coated

The concentration of tiamulin hydrogen fumarate in the drinking water must be adjusted to compensate for variation in water consumption due to weight or size of the pig, environmental temperature and other factors. It is important that pigs receive the proper drug dose, 3.5 mg tiamulin hydrogen fumarate per pound for swine dysentery or 10.5 mg tiamulin hydrogen fumarate per pound for swine pneumonia, each day for 5 consecutive days. Directions for preparing Denagard medicated solutions Determine the amount of Denagard Liquid Concentrate needed to medicate the desired volume of drinking water at the proper concentration. Carefully measure out this amount, add it to the water and stir to thoroughly mix. 1. Prepare fresh medicated drinking water every day for the 5 day treatment period. 2. Water medicated with Denagard should be the only source of drinking water during the treatment period. *3. Increase or decrease dilution rate as required to obtain proper daily drug dose. Number of pigs this bottle will treat for ONE day based on water consumption per pig One Liter Net tiamulin hydrogen fumarate content: 125,000 mg Diseases to be treated: Swine Dysentery Swine Pneumonia Daily tiamulin hydrogen fumarate required per pound body weight: 3.5 mg 10.5 mg Required treatment duration: 5 days 5 days Pig Wt, lb Water Intake, gal # of Pigs # of Pigs 20 0.3 - 0.5 1,786 595 45 0.4 - 1.1 794 265 75 0.7 - 1.5 476 159 125 1.0 - 2.0 286 95 180 1.2 - 3.0 198 66 Suggested final dilution of: 1 bottle (1 Liter) 550 gal 183 gal 3 bottles (3 Liters) 1650 gal 550 gal ½ bottle (0.5 Liters) 275 gal 92 gal Tiamulin hydrogen fumarate concentration per gallon at suggested final dilution* 227 mg (60 ppm) 681 mg (180 ppm) 1. Prepare fresh medicated drinking water every day for the 5 day treatment period. 2. Water medicated with Denagard should be the only source of drinking water during the treatment period. *3. Increase or decrease dilution rate as required to obtain proper daily drug dose. Number of pigs this bottle will treat for ONE day based on water consumption per pig Five Liters Net tiamulin hydrogen fumarate content: 625,000 mg Diseases to be treated: Swine Dysentery Swine Pneumonia Daily tiamulin hydrogen fumarate required per pound body weight: 3.5 mg 10.5 mg Required treatment duration: 5 days 5 days Pig Wt, lb Water Intake, gal # of Pigs # of Pigs 20 0.3 - 0.5 8,930 2,975 45 0.4 - 1.1 3,970 1,325 75 0.7 - 1.5 2,380 795 125 1.0 - 2.0 1,430 475 180 1.2 - 3.0 990 330 Suggested final dilution of: 1 bottle (5 Liters) 2750 gal 917 gal 3 bottles (15 Liters) 8250 gal 2750 gal ½ bottle (2.5 Liters) 1375 gal 458 gal Tiamulin hydrogen fumarate concentration per gallon at suggested final dilution* 227 mg (60 ppm) 681 mg (180 ppm) Directions for using Denagard In medicated proportioners: One liter of Denagard Liquid Concentrate mixed with water to make 4.3 gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 227 mg of tiamulin hydrogen fumarate per gallon to 550 gallons of drinking water for treatment of swine dysentery. Three liters of Denagard Liquid Concentrate mixed with water to make 4.3 gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 681 mg tiamulin hydrogen fumarate per gallon to a total of 550 gallons of drinking water for treatment of swine pneumonia. In medicated proportioners: Five liters of Denagard Liquid Concentrate mixed with water to make 21.5 gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 227 mg of tiamulin hydrogen fumarate per gallon to 2750 gallons of drinking water for treatment of swine dysentery. Fifteen liters of Denagard Liquid Concentrate mixed with water to make 21.5 gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 681 mg tiamulin hydrogen fumarate per gallon to a total of 2750 gallons of drinking water for treatment of swine pneumonia. In barrels or tanks: One liter (1000 mL) of Denagard Liquid Concentrate will medicate 550 gallons of drinking water at 227 mg per gallon for treatment of swine dysentery or 183 gallons at 681 mg per gallon for treatment of swine pneumonia. Measure Denagard Liquid Concentrate carefully, pour into the proper amount of water and thoroughly mix. The concentration of tiamulin hydrogen fumarate in the stock solution and in the drinking water delivered must be adjusted to compensate for variation in water consumption by pigs due to body weight, environmental and other factors. It is important that the pigs receive the proper drug dose of 3.5 mg of tiamulin hydrogen fumarate per pound of body weight daily for 5 consecutive days for treatment of swine dysentery or a dose of 10.5 mg per pound body weight daily for 5 consecutive days for treatment of swine pneumonia. Attention: If no response to treatment is obtained within 5 days re-establish the diagnosis. Failure of response may be related to the presence of non-susceptible organisms of other complicating disease conditions. Because of the tendency for the disease to recur on premises with a history of swine dysentery or with swine pneumonia, a control program should be implemented after treatment. Drugs are not substitutes for proper sanitary measures or good management, but should be used in conjunction with such practices.

ORAL

Denagard™ 12.5% (tiamulin hydrogen fumarate)

The concentration of tiamulin hydrogen fumarate in the drinking water must be adjusted to compensate for variation in water consumption due to weight or size of the pig, environmental temperature and other factors. It is important that pigs receive the proper drug dose, 3.5 mg tiamulin hydrogen fumarate per pound for swine dysentery or 10.5 mg tiamulin hydrogen fumarate per pound for swine pneumonia, each day for 5 consecutive days. Directions for preparing Triamulox Liquid Concentrate medicated solutions: Determine the amount of Triamulox needed to medicate the desired volume of drinking water at the proper concentration. Carefully measure out this amount, add it to the water and stir to thoroughly mix. Table 2 Triamulox Liquid Concentrate *Note: Increase or decrease dilution rate as required to obtain proper daily drug dose. Directions for using Triamulox Liquid Concentrate in medicated proportioners: One quart of Triamulox mixed with water to make four gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 227 mg of tiamulin hydrogen fumarate per gallon to 512 gallons of drinking water for treatment of swine dysentery. Three quarts of Triamulox mixed with water to make four gallons of stock solution and this stock solution metered at one -fluid ounce per gallon will provide 681 mg tiamulin hydrogen fumarate per gallon to a total of 512 gallons of drinking water for treatment of swine pneumonia. One pint of Triamulox mixed with water to make two gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 227 mg of tiamulin hydrogen fumarate per gallon to 256 gallons of drinking water for treatment of swine dysentery. Use three pints of Triamulox in two gallons of stock solution to be metered at one fluid ounce per gallon to deliver 681 mg per gallon to a total of 256 gallons of drinking water for treatment of swine pneumonia. One-half pint (8 -fluid ounces) of Triamulox diluted with water to make one gallon of stock solution and this stock solution metered at one fluid ounce of drinking water with a medication proportioner will provide 227 mg of tiamulin hydrogen fumarate per gallon to 128 gallons of drinking water for treatment of swine dysentery. Use one and one-half pints of Triamulox per gallon of stock solution to be metered at one fluid ounce per gallon to provide 681 mg per gallon to 128 gallons of drinking water for treatment of swine pneumonia. In barrels or tanks: Three fluid ounces of Triamulox will medicate 48 gallons of drinking water at 227 mg per gallon for treatment of swine dysentery or 16 gallons at 681 mg per gallon for treatment of swine pneumonia. Measure Triamulox carefully, pour into the proper amount of water and thoroughly mix. The concentration of tiamulin hydrogen fumarate in the stock solution and in the drinking water delivered must be adjusted to compensate for variation in water consumption by pigs due to body weight, environmental and other factors. It is important that the pigs receive the proper drug dose of 3.5 mg of tiamulin hydrogen fumarate per pound of body weight daily for 5 consecutive days for treatment of swine dysentery or a dose of 10.5 mg per pound body weight daily for 5 consecutive days for treatment of swine pneumonia. Attention: If no response to treatment is obtained within 5 days re-establish the diagnosis. Failure of response may be related to the presence of non-susceptible organisms of other complicating disease conditions. Because of the tendency for the disease to recur on premises with a history of swine dysentery or with swine pneumonia, a control program should be implemented after treatment. Drugs are not substitutes for proper sanitary measures or good management, but should be used in conjunction with such practices.

ORAL

TriamuloxLiquid Concentrate

Administered in the drinking water for five consecutive days for the treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin at a dose level of 3.5 milligrams tiamulin hydrogen fumarate per pound of body weight daily and for treatment of swine pneumonia due to Actinobacillus pleuropneumoniae susceptible to tiamulin when given at 10.5 milligrams tiamulin hydrogen fumarate per pound of body weight daily.

Oral

Use as only source of drinking water. Prepare fresh medicated water daily. Withdraw medicated water 3 days before slaughter following treatment at 3.5 mg/lb and 7 days before slaughter following treatment at 10.5 mg/lb of body weight. Swine being treated with tiamulin should not have access to feeds containing polyether ionophores (e.g., lasalocid, monensin, narasin, salinomycin, or semduramycin) as adverse reactions may occur. The effects of tiamulin on swine reproductive performance, pregnancy, and lactation have not been determined

Triamulox™

Use Directions: The concentration of tiamulin hydrogen fumarate in the drinking water must be adjusted to compensate for variation in water consumption due to weight or size of the pig, environmental temperature and other factors. It is important that pigs receive the proper drug dose, 3.5 mg tiamulin hydrogen fumarate per pound for swine dysentery or 10.5 mg tiamulin hydrogen fumarate per pound for swine pneumonia, each day for 5 consecutive days.

ORAL

Vetmulin® 12.5%(tiamulin hydrogen fumarate)