vitamin e

Cattle (weanling calves)

For the prevention and treatment of selenium-tocopherol deficiency syndrome.

Discontinue use 30 days before treated cattle are slaughtered for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Velenium™

Cattle (breeding beef cows)

For the prevention and treatment of selenium-tocopherol deficiency syndrome.

Discontinue use 30 days before treated cattle are slaughtered for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Velenium™

Cattle (Calves)

For prevention and treatment of white muscle disease (selenium-tocopherol deficiency syndrome).

Anaphylactoid reactions, some of which have been fatal, have been reported in animals administered BO-SE Injection.

BO-SE

Cattle (Breeding Beef Cattle)

MU-SE (selenium, vitamin E) is recommended for the prevention and treatment of STD syndrome.

Do not use in adult dairy cattle. Premature births and abortions have been reported in dairy cattle injected with this product during the third trimester of pregnancy.

Mu-Se

Cattle (Weanling Calves)

MU-SE (selenium, vitamin E) is recommended for the prevention and treatment of STD syndrome.

Do not use in adult dairy cattle. Premature births and abortions have been reported in dairy cattle injected with this product during the third trimester of pregnancy.

Mu-Se

Swine (Weanling Pigs)

As an aid in the prevention and treatment of diseases associated with Selenium-Tocopherol deficiency, such as hepatic necrosis, mulberry heart disease, and white muscle disease.

Anaphylactoid reactions, some of which have been fatal, have been reported in animals administered BO-SE Injection. Not for use in newborn pigs.

BO-SE

Swine (Sows)

As an aid in the prevention and treatment of diseases associated with Selenium-Tocopherol deficiency, such as hepatic necrosis, mulberry heart disease, and white muscle disease.

Anaphylactoid reactions, some of which have been fatal, have been reported in animals administered BO-SE Injection.

BO-SE

Sheep (Lambs- 2 weeks of age and older)

For prevention and treatment of white muscle disease (selenium-tocopherol deficiency syndrome).

Anaphylactoid reactions, some of which have been fatal, have been reported in animals administered BO-SE Injection.

BO-SE

Sheep (Ewes)

For prevention and treatment of white muscle disease (selenium-tocopherol deficiency syndrome).

Anaphylactoid reactions, some of which have been fatal, have been reported in animals administered BO-SE Injection.

BO-SE

The drug is intended for use as an aid in alleviating and controlling inflammation, pain and lameness associated with certain arthropathies in dogs.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Seletoc® Injection

As an aid in alleviating and controlling inflammation, pain, and lameness associated with certain arthropathies in dogs.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Seletoc® Minicaps and Caps

The drug is intended for use for the prevention and treatment of selenium-tocopherol deficiency syndrome in horses.

E-SE

INDICATIONS BO-SE (selenium, vitamin E) is recommended for the prevention and treatment of white muscle disease (Selenium-Tocopherol Deficiency) syndrome in calves, lambs, and ewes. Clinical signs are: stiffness and lameness, diarrhea and unthriftiness, pulmonary distress and/or cardiac arrest. In sows and weanling pigs, as an aid in the prevention and treatment of diseases associated with Selenium-Toco pherol deficiency, such as hepatic necrosis, mulberry heart disease, and white muscle disease. Where known deficiencies of selenium and/or vitamin E exist, it is advisable, from the prevention and control standpoint, to inject the sow during the last week of pregnancy.

BO-SE® (SELENIUM, VITAMIN E) Injection

INDICATIONS MU-SE (selenium, vitamin E) is recommended for the prevention and treatment of STD syndrome in weanling calves and breeding beef cattle. Clinical signs are: stiffness and lameness; chronic, persistent diarrhea; unthriftiness; abortions and/or weak premature calves.

MU-SE® (SELENIUM, VITAMIN E) Injection

INDICATIONS E-SE Injection is recommended for the control of the following clinical signs when associated with myositis (Selenium-Tocopherol Deficiency) syndrome: rapid respiration, profuse sweating, muscle spasms and stiffness, elevated SGOT.

E-SE® (SELENIUM, VITAMIN E) Injection

FOR VETERINARY USE ONLY

BO-SE® (SELENIUM, VITAMIN E) Injection

PHARMACOLOGY It has been demonstrated that selenium and tocopherol exert physiological effects and that these effects are intertwined with sulfur metabolism. Additionally, tocopherol appears to have a significant role in the oxidation process, thus suggesting an interrelationship between selenium and tocopherol in overcoming sulfur-induced depletion and restoring normal metabolism. Although oral ingestion of adequate amounts of selenium and tocopherol would seemingly restore normal metabolism, it is apparent that the presence of sulfur and, perhaps, other factors interfere during the digestive process with proper utilization of selenium and tocopherol. When selenium and tocopherol are injected, they bypass the digestive process and exert their full metabolic effects promptly on cell metabolism. Anti-inflammatory action has been demonstrated by selenium-tocopherol in the Selye Pouch Technique and experimentally induced polyarthritis study in rats.

E-SE® (SELENIUM, VITAMIN E) Injection

CONTRAINDICATION Do not use in adult dairy cattle. Premature births and abortions have been reported in dairy cattle injected with this product during the third trimester of pregnancy.

MU-SE® (SELENIUM, VITAMIN E) Injection

CONTRAINDICATIONS DO NOT USE IN PREGNANT EWES. Deaths and abortions have been reported in pregnant ewes injected with this product.

BO-SE® (SELENIUM, VITAMIN E) Injection

WARNINGS Anaphylactoid reactions, some of which have been fatal, have been reported in horses administered E-SE Injection. Signs include excitement, sweating, trembling, ataxia, respiratory distress, and cardiac dysfunction. These reactions have been reported as associated both with intravenous and intramuscular injections. It is presently unknown whether the mode of application affects the frequency of such reactions. However, reactions associated with intramuscular injections have been reported to manifest more slowly and hence may give more time to institute treatment for anaphylaxis, such as epinephrine and/or corticosteroid injection. Medications which have been reported to cause major adverse reactions in horses should be avoided when E-SE is administered, unless the condition of the animal requires such use. Not to be used in horses intended for food.

E-SE® (SELENIUM, VITAMIN E) Injection

WARNINGS Anaphylactoid reactions, some of which have been fatal, have been reported in animals administered BO-SE Injection. Signs include excitement, sweating, trembling, ataxia, respiratory distress, and cardiac dysfunction. Selenium- Vitamin E preparations can be toxic when improperly administered.

BO-SE® (SELENIUM, VITAMIN E) Injection

WARNINGS Anaphylactoid reactions, some of which have been fatal, have been reported in cattle administered the MU-SE product. Signs include excitement, sweating, trembling, ataxia, respiratory distress, and cardiac dysfunction.

MU-SE® (SELENIUM, VITAMIN E) Injection

Residue Warnings: Discontinue use 30 days before the treated calves are slaughtered for human consumption. Discontinue use 14 days before the treated lambs, ewes, sows, and pigs are slaughtered for human consumption.

BO-SE® (SELENIUM, VITAMIN E) Injection

FOR USE ON ANIMALS ONLY

Soothex

ADVERSE REACTIONS Reactions, including acute respiratory distress, frothing from the nose and mouth, bloating, severe depression, abortions, and deaths have occurred in pregnant ewes. Do not use product with phase separation or turbidity.

BO-SE® (SELENIUM, VITAMIN E) Injection

Cattle (weanling calves)

1 milliliter per 200 pounds of body weight in weanling calves. For subcutaneous or intramuscular use.

Subcutaneous, Intramuscular

Discontinue use 30 days before treated cattle are slaughtered for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Velenium™

Cattle (breeding beef cows)

1 milliliter per 200 pounds of body weight during the middle third of gestation, and 30 days before calving in breeding beef cows. For subcutaneous or intramuscular use.

Subcutaneous, Intramuscular

Discontinue use 30 days before treated cattle are slaughtered for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Velenium™

Cattle (Calves)

2.5-3.75 mL per 100 lbs of body weight depending on the severity of the condition and geographical area

Intramuscular, Subcutaneous

Anaphylactoid reactions, some of which have been fatal, have been reported in animals administered BO-SE Injection.

BO-SE

Cattle (Breeding Beef Cattle)

1 mL per 200 pounds of body weight during the middle third of pregnancy, and 30 days before calving.

Intramuscular, Subcutaneous

Do not use in adult dairy cattle. Premature births and abortions have been reported in dairy cattle injected with this product during the third trimester of pregnancy.

Mu-Se

Cattle (Weanling Calves)

1 mL per 200 pounds of body weight.

Intramuscular, Subcutaneous

Do not use in adult dairy cattle. Premature births and abortions have been reported in dairy cattle injected with this product during the third trimester of pregnancy.

Mu-Se

Swine (Weanling Pigs)

1 mL per 40 lbs body weight (minimum, 1 mL).

Intramuscular, Subcutaneous

Anaphylactoid reactions, some of which have been fatal, have been reported in animals administered BO-SE Injection. Not for use in newborn pigs.

BO-SE

Swine (Sows)

1 mL per 40 lbs of body weight.

Intramuscular, Subcutaneous

Anaphylactoid reactions, some of which have been fatal, have been reported in animals administered BO-SE Injection.

BO-SE

Sheep (Lambs- 2 weeks of age and older)

1 mL per 40 lbs body weight (minimum, 1 mL).

Intramuscular, Subcutaneous

Anaphylactoid reactions, some of which have been fatal, have been reported in animals administered BO-SE Injection.

BO-SE

Sheep (Ewes)

2.5 mL per 100 lb body weight.

Intramuscular, Subcutaneous

Anaphylactoid reactions, some of which have been fatal, have been reported in animals administered BO-SE Injection.

BO-SE

The capsules are administered orally with the larger capsules administered at a dosage level of 1 capsule per 20 pounds of body weight to a maximum of 5 capsules with the dosage repeated at 3 day intervals until a satisfactory therapeutic response is observed. A maintenance dosage is then administered consisting of 1 capsule per 40 pounds of body weight, with a minimum of 1 capsule per 40 pounds of body weight, with a minimum of 1 capsule, given every 3 days, or 7 days, or longer, as required to maintain improvement or an asymptomatic condition. For dogs under 20 pounds of body weight, the small capsules are administered orally at a dosage level of 1 per 5 pounds of body weight with a minimum of 1 capsule which dosage is repeated at 3 day intervals until a satisfactory response is observed then a maintenance regimen is initiated with 1 capsule per 10 pounds of body weight, minimum of 1 capsule, every 3 days, or 7 days, or longer as required to maintain continued improvement or an asymptomatic condition.

Oral

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Seletoc® Minicaps and Caps

The drug is administered subcutaneously or intramuscularly in divided doses in 2 or more sites at a dosage level of 1 milliliter per 20 pounds of body weight with a minimum dosage of 1/4 milliliter and a maximum dosage of 5 milliliters. The dosage is repeated at 3 day intervals until a satisfactory therapeutic response is observed. A maintenance regimen is then initiated which consists of 1 milliliter per 40 pounds of body weight with a minimum dosage of 1/4 milliliter which is repeated every 3 days or 7 days or longer, as required to maintain continued improvement or an asymptomatic condition; or the drug may be used in capsule form for oral maintenance therapy.

Intramuscular, Subcutaneous

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Seletoc® Injection

1 milliliter per 100 pounds of body weight and may be repeated at 5 to 10 day intervals.

Intramuscular, Intravenous

E-SE

DOSAGE AND ADMINISTRATION Inject subcutaneously or intramuscularly. Calves: 2.5-3.75 mL per 100 pounds of body weight depending on the severity of the condition and the geographical area. Lambs 2 weeks of age and older: 1 mL per 40 pounds of body weight (minimum, 1 mL). Ewes: 2.5 mL per 100 pounds of body weight. Sows: 1 mL per 40 pounds of body weight. Weanling pigs: 1 mL per 40 pounds of body weight (minimum, 1 mL). Not for use in newborn pigs.

SUBCUTANEOUS, INTRAMUSCULAR

BO-SE® (SELENIUM, VITAMIN E) Injection

DOSAGE AND ADMINISTRATION Administration: slow intravenous injection (see WARNINGS ) or deep intramuscular injections, in divided doses, in two or more sites in the gluteal or cervical muscles. Dosage: 1 mL per 100 pounds of body weight. May be repeated at 5-10 day intervals.

INTRAVENOUS, INTRAMUSCULAR

E-SE® (SELENIUM, VITAMIN E) Injection

DOSAGE AND ADMINISTRATION Inject subcutaneously or intramuscularly. Weanling calves: 1 mL per 200 pounds of body weight. Breeding beef cows: 1 mL per 200 pounds of body weight during the middle third of pregnancy, and 30 days before calving.

SUBCUTANEOUS, INTRAMUSCULAR

MU-SE® (SELENIUM, VITAMIN E) Injection