Danofloxacin

Cattle (Excluding Veal Calves)

For the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica and Pasteurella multocida and for the control of BRD in beef cattle at high risk of developing BRD associated with Mannheimia haemolytica and Pasteurella multocida.

Advocin™ Sterile Injectable Solution

Cattle (Excluding Veal Calves)

For the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica and Pasteurella multocida

Advocin™ Sterile Injectable Solution

For the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica and Pasteurella multocida in beef cattle and for the control of BRD in beef cattle at high risk of developing BRD associated with Mannheimia haemolytica and Pasteurella multocida.

ADVOCIN™(danofloxacin injection)

For use in animals only. Keep out of reach of children. Avoid contact with eyes. In case of contact, immediately flush eyes with copious amounts of water for 15 minutes. In case of dermal contact, wash skin with soap and water. Consult a physician if irritation persists following ocular or dermal exposures. Individuals with a history of hypersensitivity to quinolones should avoid this product. In humans, there is a risk of user photosensitization within a few hours after excessive exposure to quinolones. If excessive accidental exposure occurs, avoid direct sunlight. To report adverse reactions or to obtain a copy of the Safety Data Sheet (SDS), call 1-888-963-8471.

ADVOCIN™(danofloxacin injection)

Animals intended for human consumption must not be slaughtered within 4 days from the last treatment. Do not use in cattle intended for dairy production. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

ADVOCIN™(danofloxacin injection)

A hypersensitivity reaction was noted in 2 healthy calves treated with ADVOCIN in a laboratory study. In one location of a multi-site field trial, one out of the 41 calves treated with 6 mg/kg q 48 hours showed lameness on Day 6 only. In this same field trial location one of 38 calves treated with 8 mg/kg once became lame 4 days after treatment and remained lame on the last day of the study (Day 10). Another calf in the same treatment group developed lameness on the last day of the study.

ADVOCIN™(danofloxacin injection)

Cattle (Excluding Veal Calves)

Administer subcutaneously at 6 mg/kg of body weight (1.5 mL/100 lb) with this treatment repeated once approximately 48 hours following the first injection. Administered dose volume should not exceed 15 mL per injection site.

Subcutaneous

Advocin™ Sterile Injectable Solution

Cattle (Excluding Veal Calves)

Administer subcutaneously at 8 mg/kg of body weight (2 mL/100 lb) as a one-time injection. Administered dose volume should not exceed 15 mL per injection site.

Subcutaneous

Advocin™ Sterile Injectable Solution

Care should be taken to dose accurately. Administered dose volume should not exceed 15 mL per injection site. Single-Dose Therapy (BRD Treatment and Control in Cattle at High Risk): Administer subcutaneously at 8 mg/kg of body weight (2 mL/100 lb) as a one-time injection. Multi-Day Therapy (BRD Treatment): Administer subcutaneously at 6 mg/kg of body weight (1.5 mL/100 lb) with this treatment repeated once approximately 48 hours following the first injection. ADVOCIN Dosage and Treatment Schedule Dose Volume (mL) Cattle Weight (lb) 6 mg/kg, given twice, 48 hours apart (treatment) 8 mg/kg given once (treatment and control in cattle at high risk) 50 0.75 1 100 1.5 2 150 2.25 3 200 3 4 250 3.75 5 300 4.5 6 400 6 8 500 7.5 10 600 9 12 700 10.5 14 800 12 16Administered dose volume should not exceed 15 mL per injection site. 900 13.5 18 1000 15 20 * Administered dose volume should not exceed 15 mL per injection site.

SUBCUTANEOUS

ADVOCIN™(danofloxacin injection)