Doxycycline

Dogs (Over 1 Year)

DOXIROBE Gel is indicated for the treatment and control of periodontal disease in dogs.

Do not use in dogs less than 1-year old. Use of tetracyclines during tooth development has been associated with permanent discoloration of teeth. Do not use in pregnant bitches. Use in breeding dogs has not been evaluated. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Doxirobe™ Gel

Diagnostic Chart Fin and Tail Rot: Fins appear ragged and split. In severe cases, fins and tail are almost completely eroded. Secondary fungal infections, observed as white, "cottony" growth, commonly occur. Bacterial Gill Disease: Fish may breathe heavily and show bright red gills. Fish may sit at bottom of aquarium or near the water's surface. However, visual diagnosis is often difficult. Hemorrhagic Septicemia: A bacterial infection of the bloodstream. Fish may show blood streaks on the body and fins, bleeding (red patches) and localized swelling. Open Red Sores: A bacterial infection that causes open red sores on body. Infection can range from very small ulcers to deep skin lesions. Coloring can range from reddish or gray ulcers to very dark areas associated with necrotic (dying) tissue. Body Slime and Eye Cloud: Eyes develop a white haze and/or protrude from the head. Slimy patches appear on the body. Fish may scratch on objects and exhibit rapid breathing. Infection may cause abmormal osmotic funstion resulting in fluid accumulation to the eyes and/or body.

Drug Label

DOXIROBE Gel is indicated for the treatment and control of periodontal disease in dogs. Periodontal pocket probing depths ≥ 4 mm are evidence of disease that may be responsive to treatment with DOXIROBE Gel. In clinical trials, use of the product resulted in attachment level gains, periodontal pocket depth reductions and improved gingival health. Noticeable improvements in these parameters should be evident within 2-4 weeks following treatment. The response in individual animals is dependent on the severity of the condition and rigor of adjunctive therapy. This product is not intended for use in oronasal fistulas, periapical abscesses, or severely compromised teeth.

Doxirobe® Gel

KEEP OUT OF THE REACH OF CHILDREN. For aquarium use only. Not for human consumption or for the treatment of fish intended for human consumption. Avoid contact with skin and eyes. May cause irritation. ! WARNING: This product can expose you to chemicals including Silica, crystalline, which is known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Drug Label

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Doxirobe® Gel

Dogs (Over 1 Year)

Apply subgingivally to periodontal pocket(s) of affected teeth.

Subgingival

Do not use in dogs less than 1-year old. Use of tetracyclines during tooth development has been associated with permanent discoloration of teeth. Do not use in pregnant bitches. Use in breeding dogs has not been evaluated. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Doxirobe™ Gel

Teeth should be cleaned and scaled prior to application of the product. If required, root planing and debridement of affected sites should be performed. The product is applied with the animal under sedation or anesthesia. Use as many units as required to fill the periodontal pockets of affected teeth. Picture 1 Each pouch contains 2 syringes and a blunt cannula. Syringe A contains the polymer delivery system and Syringe B contains doxycycline. Lock the syringes together. Picture 2 Beginning with Syringe A, use the plungers of Syringes A and B to exchange the material between the syringes approximately 100 times to achieve a consistent mixture. Picture 3 Fully deliver the mixture into Syringe A, separate the syringes, and lock the supplied blunt cannula onto Syringe A. The cannula may be bent to the desired angle. Picture 4 Gently place the cannula 1-2 mm below the gingival margin of an affected tooth. Express a small amount of the mixture into each periodontal pocket 4 mm or deeper. Ensure that the pockets are filled approximately to the gingival margin. Picture 5 The formulation will begin to solidify immediately upon application; however, lavage with a few drops of water or saline will facilitate the process. Allow approximately 30-60 seconds for the polymer to harden before beginning to press it into the pocket Picture 6 The exposed surface of the product may be pressed into the pocket with the edge of a wax spatula or the back of a curette. Pressure may be applied to the gingival margin to avoid dislodging the polymer inadvertently. As the product is biodegradable, removal at a subsequent visit is not required. Treatment and control of periodontal disease requires a comprehensive program of routine scaling and cleaning, home care and dental hygiene (e.g., brushing, rinses or the use of chewing devices) in addition to application of this product. Severe cases may require surgical intervention. Reconstituted product not used on the day of mixing should be stored in the resealable foil pouch at room temperature (15-25°C or 59-77°F) and used within 3 days of reconstitution. Ten additional exchanges between syringes should be performed if reconstituted product has been stored.

PERIODONTAL

Doxirobe® Gel

Directions for Use: For best results, remove activated carbon or filter cartridge from filter and continue aeration. For each 10 gallons (38 L) of water, empty one packet directly into aquarium. Repeat dose after 24 hours. Wait another 24 hours then change 25% of the aquarium water. Repeat this treatment for a second time, for a total of 4 doses. Then make a final 25% water change and add fresh activated carbon or replace filter cartridge. Treatment may be repeated, if necessary. Note: This medication will cause a slight discoloration of water which can be removed with API BIO-CHEM ZORB or activated carbon This package treats up to 100 gallons. Four doses required for full course of treatment.

TOPICAL

Drug Label