DOSE AND ADMINISTRATION
100 mL: Use within 28 days of first puncture and puncture a maximum of 19 times. If using a needle larger than 16 gauge, discard any product remaining in the vial immediately after use.
250 mL: Use within 28 days of first puncture and puncture a maximum of 30 times. If more than 30 punctures are anticipated, the use of multi-dosing equipment is recommended. Puncture a maximum of 5 times with a dosage delivery device no larger than 4 gauge. Any product remaining beyond these parameters should be discarded.
Horse: The recommended dose for musculoskeletal disorders is 0.5 mg per pound (1 mL/100 lbs) of body weight once daily. Treatment may be given by intravenous or intramuscular injection and repeated for up to 5 days. Studies show onset of activity is within 2 hours. Peak response occurs between 12 and 16 hours and duration of activity is 24-36 hours.
The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg per pound of body weight. Intravenous administration is recommended for prompt relief. Clinical studies show pain is alleviated in less than 15 minutes in many cases. Treatment may be repeated when signs of colic recur. During clinical studies approximately 10% of the horses required one or two additional treatments. The cause of colic should be determined and treated with concomitant therapy.
Cattle: The recommended dose for control of pyrexia associated with bovine respiratory disease and endotoxemia and control of inflammation in endotoxemia is 1.1 to 2.2 mg/kg (0.5 to 1.0 mg/lb; 1 to 2 mL per 100 lbs) of body weight given by slow intravenous administration either once a day as a single dose or divided into two doses administered at 12-hour intervals for up to 3 days. The total daily dose should not exceed 2.2 mg/kg (1.0 mg/lb) of body weight. Avoid rapid intravenous administration of the drug.
The recommended dose for acute bovine mastitis is 2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) of body weight given once by intravenous administration.
INTRAVENOUS, INTRAMUSCULAR
FDA application 200-387
DOSE AND ADMINISTRATION
Use within 28 days of first puncture and puncture a maximum of 30 times. If more than 30 punctures are anticipated, the use of multi-dosing equipment is recommended. Puncture a maximum of 5 times with a dosage delivery device no larger than 4 gauge. Any product remaining beyond these parameters should be discarded.
Horse: The recommended dose for musculoskeletal disorders is 0.5 mg per pound (1 mL/100 lbs) of body weight once daily. Treatment may be given by intravenous or intramuscular injection and repeated for up to 5 days. Studies show onset of activity is within 2 hours. Peak response occurs between 12 and 16 hours and duration of activity is 24-36 hours.
The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg per pound of body weight. Intravenous administration is recommended for prompt relief. Clinical studies show pain is alleviated in less than 15 minutes in many cases. Treatment may be repeated when signs of colic recur. During clinical studies approximately 10% of the horses required one or two additional treatments. The cause of colic should be determined and treated with concomitant therapy.
Cattle: The recommended dose for control of pyrexia associated with bovine respiratory disease and endotoxemia and control of inflammation in endotoxemia is 1.1 to 2.2 mg/kg (0.5 to 1.0 mg/lb; 1 to 2 mL per 100 lbs) of body weight given by slow intravenous administration either once a day as a single dose or divided into two doses administered at 12-hour intervals for up to 3 days. The total daily dose should not exceed 2.2 mg/kg (1.0 mg/lb) body weight. Avoid rapid intravenous administration of the drug.
The recommended dose for acute bovine mastitis is 2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) of body weight given once by intravenous administration.
INTRAMUSCULAR, INTRAVENOUS
FDA application 200-387
USE WITHIN 28 DAYS OF FIRST PUNCTURE AND PUNCTURE A MAXIMUM OF 10 TIMES FOR 100 ML FILL, 25 TIMES FOR 250 ML FILL AND 50 TIMES FOR 500 ML FILL. WHEN USING A DRAW-OFF SPIKE, DISCARD ANY PRODUCT REMAINING IN THE VIAL IMMEDIATELY AFTER USE.
Horse:
The recommended dose for musculoskeletal disorders is 0.5 mg per pound (1 mL/100 lbs) of body weight once daily. Treatment may be given by intravenous or intramuscular injection and repeated for up to 5 days. Studies show onset of activity is within 2 hours. Peak response occurs between 12 and 16 hours and duration of activity is 24-36 hours.
The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg per pound of body weight. Intravenous administration is recommended for prompt relief. Clinical studies show pain is alleviated in less than 15 minutes in many cases. Treatment may be repeated when signs of colic recur. During clinical studies approximately 10% of the horses required one or two additional treatments. The cause of colic should be determined and treated with concomitant therapy.
Cattle: The recommended dose for control of pyrexia associated with bovine respiratory disease and endotoxemia and control of inflammation in endotoxemia, is 1.1 to 2.2 mg/kg (0.5 to 1 mg/lb; 1 to 2 mL per 100 lbs) of body weight given by slow intravenous administration either once a day as a single dose or divided into two doses administered at 12-hour intervals for up to 3 days. The total daily dose should not exceed 2.2 mg/kg (1.0 mg/lb) of body weight. Avoid rapid intravenous administration of the drug.
The recommended dose for acute bovine mastitis is 2.2 mg/kg (1 mg/lb; 2 ml per 100 lbs) of body weight given once by intravenous administration.
INTRAVENOUS, INTRAMUSCULAR
FDA application 200-781
Dose and Administration
Horse:
The recommended dose for musculoskeletal disorders is 0.5 mg per pound (1
mL/100 lbs) of body weight once daily. Treatment may be given by intravenous or intramuscular
injection and repeated for up to 5 days. Studies show onset of activity is within 2 hours. Peak
response occurs between 12 and 16 hours. Peak response occurs between 12 and 16 hours and
duration of activity is 24-36 hours.
The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg per pound
of body weight. Intravenous administration is recommended for prompt relief. Clinical studies
show pain is alleviated in less than 15 minutes in many cases. Treatment may be repeated when
signs of colic recur. During clinical studies approximately 10% of the horses required one or
two additional treatments. The cause of colic should be determined and treated with
concomitant therapy.
Cattle:
The recommended dose for control of pyrexia associated with bovine respiratory
disease and endotoxemia and control of inflammation in endotoxemia is 1.1 to 2.2 mg/kg
(0.5 to 1 mg/lb;1 to 2 mL per 100 lbs) of body weight given by slow intravenous administration
either once a day as a single dose or divided into two doses administered at 12-hour intervals for
up to 3 days. The total daily dose should not exceed 2.2 mg/kg (1.0 mg/lb) of body weight.
Avoid rapid intravenous administration of the drug.
The recommended dose for acute bovine mastitis is 2.2 mg/kg (1.0 mg/lb; 2 mL per 100 lbs) of body
weight given once by intravenous administration.
INTRAVENOUS, INTRAMUSCULAR
FDA application 200-061
DOSAGE AND ADMINISTRATION: The recommended dose of flunixin meglumine is 0.5 mg per lb of body weight once daily. The VetaMeg Equine Paste syringe, calibrated in twelve 250-lb weight increments, delivers 125 mg of flunixin for each 250 lbs (see dosage table). One syringe will treat a 1000-lb horse once daily for 3 days, or three 1000-lb horses one time.
DOSAGE TABLE
Syringe Mark*
Horse Weight (lbs)
VetaMeg™ Equine Paste Delevered (g)
mg Flunixin Delivered
0
---
---
---
250
250
2.5
125
500
500
5.0
250
750
750
7.5
375
1000
1000
10.0
500
* Use dial edge nearest syringe barrel to mark dose.
The paste is orally administered by inserting the nozzle of the syringe through the interdental space, and depositing the required amount of paste on the back of the tongue by depressing the plunger.
Treatment may be given initially by intravenous or intramuscular injection of VetaMeg Injectable Solution, followed by VetaMeg Equine Paste on Days 2 to 5. Flunixin meglumine treatment should not exceed 5 consecutive days.
TOXICITY: No toxic effects were observed in rats given oral flunixin meglumine 2 mg/kg per day for 42 days. Higher doses produced ulceration of the gastrointestinal tract. The emetic dose in dogs is between 150 and 250 mg/kg. Flunixin was well tolerated in monkeys dosed daily with 4 mg/kg for 56 days. No adverse effects occurred in horses dosed orally with 1.0 or 1.5 mg/lb for 5 consecutive days.
ORAL
FDA application 200-581
DOSAGE AND ADMINISTRATION The recommended dose of flunixin is 0.5 mg per lb of body weight once daily. The BANAMINE Paste syringe, calibrated in twelve 250-lb weight increments, delivers 125 mg of flunixin for each 250 lbs (see dosage table). One syringe will treat a 1000-lb horse once daily for 3 days, or three 1000-lb horses one time.
DOSAGE TABLE
Syringe MarkUse dial edge nearest syringe barrel to mark dose.
Horse Weight (lbs)
BANAMINE Paste Delivered (g)
Mg Flunixin Delivered
0
—
—
—
250
250
2.5
125
500
500
5.0
250
750
750
7.5
375
1000
1000
10.0
500
The paste is orally administered by inserting the nozzle of the syringe through the interdental space, and depositing the required amount of paste on the back of the tongue by depressing the plunger.
Treatment may be given initially by intravenous or intramuscular injection of BANAMINE Solution, followed by BANAMINE Granules or BANAMINE Paste on Days 2 to 5. BANAMINE treatment should not exceed 5 consecutive days.
ORAL
Banamine® (flunixin meglumine paste)
DOSAGE AND ADMINISTRATION
The recommended dose for swine is 2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) body weight given by a single intramuscular administration. The injection should be given only in the neck musculature with a maximum of 10 mL per site.
100 mL: Use within 28 days of first puncture and puncture a maximum of 19 times. If using a needle larger than 16 gauge, discard any remaining product in the vial immediately after use.
250 mL: Use within 28 days of first puncture and puncture a maximum of 30 times with a needle or 5 times with a dosage delivery device. If using a needle larger than 4 gauge, discard any remaining product in the vial immediately after use.
Note: Intramuscular injection may cause local tissue irritation and damage. In an injection-site irritation study, the tissue damage did not resolve in all animals by Day 28 post-injection. This may result in trim loss of edible tissue at slaughter.
INTRAMUSCULAR
FDA application 200-489
DOSAGE AND ADMINISTRATION: Apply only once at a dose of 3.3 mg flunixin per kg body weight (1.5 mg/lb; 3 mL per 100 lbs) topically in a narrow strip along the dorsal midline from the withers to the tailhead. Round the dose up to the nearest weight increment on the dosing chamber. If pyrexia, or the pain associated with foot rot persists, the diagnosis should be re-evaluated and alternative therapy considered. Do not treat cattle if the hide is wet or may get wet in the six hours after dosing because effectiveness has not been evaluated under wet hide conditions.
Practice the Administration and Overfill Reduction Instructions a few times to become familiar with operating the package before dosing animals.
If the dosing chamber is overfilled follow the Overfill Reduction Instructions.
A small amount of liquid will remain on the walls of the chamber, but the chamber is calibrated to account for this.
TRANSDERMAL
Banamine® Transdermal(flunixin transdermal solution)
Horse: The recommended dose for musculoskeletal disorders is 0.5 mg per pound (1 mL/100 lbs) of bodyweight once daily. Treatment may be given by intravenous or intramuscular injection and repeated for up to five days. Studies show onset of activity is within 2 hours. Peak response occurs between 12 and 16 hours and duration of activity is 24-36 hours.
The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg per pound of bodyweight. Intravenous administration is recommended for prompt relief. Clinical studies show pain is alleviated in less than 15 minutes in many cases. Treatment may be repeated when signs of colic recur. During clinical studies approximately 10% of the horses required one or two additional treatments. The cause of the colic should be determined and treated with concomitant therapy.
INTRAMUSCULAR, INTRAVENOUS
covetrus® Flunixin Injection(flunixin meglumine injection)50 mg/ml
The recommended dose for swine is 2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) body weight given by a single intramuscular administration. The injection should be given only in the neck musculature with a maximum of 10 mL per site.
USE WITHIN 28 DAYS OF FIRST PUNCTURE AND PUNCTURE A MAXIMUM OF 10 TIMES. WHEN USING A DRAW-OFF SPIKE OR NEEDLE WITH BORE DIAMETER LARGER THAN 18 GAUGE, DISCARD ANY PRODUCT REMAINING IN THE VIAL IMMEDIATELY AFTER USE.
Note: Intramuscular injection may cause local tissue irritation and damage. In an injection-site irritation study, the tissue damage did not resolve in all animals by Day 28 post-injection. This may result in trim loss of edible tissue at slaughter.
INTRAMUSCULAR
Banamine®-S (flunixin meglumine injection)
DOSAGE AND ADMINISTRATION: RESFLOR GOLD® should be administered once by subcutaneous injection at a dose rate of 40 mg florfenicol/kg body weight and 2.2 mg flunixin/kg body weight (6 mL/100 lb). Do not administer more than 10 mL at each site. The injection should be given only in the neck. Injection sites other than the neck have not been evaluated. For the 500 mL vial, do not puncture the stopper more than 20 times.
RESFLOR GOLD® Dosage GuideDo not administer more than 10 mL at each site.
ANIMAL WEIGHT
(lbs)
DOSAGE
(mL)
100
6.0
Recommended Injection Location
200
12.0
300
18.0
400
24.0
500
30.0
600
36.0
700
42.0
800
48.0
900
54.0
1000
60.0
SUBCUTANEOUS
Resflor GOLD®
The recommended dose for swine is 2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) body weight given by a single intramuscular administration. The injection should be given only in the neck musculature with a maximum of 10 mL per site.
Note: Intramuscular injection may cause local tissue irritation and damage. In an injection-site irritation study, the tissue damage did not resolve in all animals by Day 28 post-injection.
This may result in trim loss of edible tissue at slaughter.
INTRAMUSCULAR
Flunixin Injection -S(flunixin meglumine injection)50 mg/mLFor intramuscular use in swine.
nixiFLOR™ should be administered once by subcutaneous injection at a dose rate of 40 mg florfenicol/kg body weight and 2.2 mg flunixin/kg body weight (6 mL/100 lb). Do not administer more than 10 mL at each site. The injection should be given only in the neck. Injection sites other than the neck have not been evaluated. For the 500 mL vial, do not puncture the stopper more than 20 times.
* Do not administer more than 10 mL at each site.
SUBCUTANEOUS
nixiFLOR™(florfenicol and flunixin meglumine)Antimicrobial/Non-Steroidal Anti-Inflammatory Drug
The recommended dose for swine is 2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) body weight given by a single intramuscular administration. The injection should be given only in the neck musculature with a maximum of 10 mL per site
Intramuscular
Not for use in breeding swine. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Flunixin Injection - S
USE WITHIN 28 DAYS OF FIRST PUNCTURE AND PUNCTURE A MAXIMUM OF 10 TIMES. WHEN USING A DRAW-OFF SPIKE OR NEEDLE WITH BORE DIAMETER LARGER THAN 18 GAUGE, DISCARD ANY PRODUCT REMAINING IN THE VIAL IMMEDIATELY AFTER USE.
INTRAVENOUS, INTRAMUSCULAR
Banamine® (flunixin meglumine injection)
0.5 mg per pound of body weight per day for up to 5 days
Oral
For oral use in horses only. Treatment should not exceed 5 consecutive days. The effect of flunixin meglumine on pregnancy has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian
Flunazine®