Levothyroxine

For replacement therapy for diminished thyroid function in dogs.

For oral use in dogs only. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Thyro-Tabs® Canine

For use in horses and ponies for correction of conditions associated with low circulating thyroid hormone (hypothyroidism).

Thyrozine Powder

INDICATION: For replacement therapy for diminished thyroid function in dogs.

Thyro-Tabs® Canine (levothyroxine sodium tablets), USP

CLINICAL PHARMACOLOGY: Levothyroxine sodium has poor oral bioavailability in dogs (10-20%) with peak serum TT4 concentrations within 4 to 6 hours (fasted state). Administration of levothyroxine sodium with food reduces oral bioavailability.5 In most dogs, the estimated half-life is approximately 10-14 hours. Levothyroxine sodium is excreted in the feces.

Thyro-Tabs® Canine (levothyroxine sodium tablets), USP

CONTRAINDICATIONS: Do not use in dogs with thyrotoxicosis or uncorrected adrenal insufficiency.

Thyro-Tabs® Canine (levothyroxine sodium tablets), USP

Administer with caution to animals with clinically significant heart disease, hypertension or other complications for which a sharply increased metabolic rate might prove hazardous. Use in pregnant mares has not been evaluated.

Thyrozine Powder

USER SAFETY WARNINGS: Not for use in humans. Keep out of reach of children. In the event of accidental ingestion, seek medical advice immediately and show the product label to the physician. Wash hands after handling.

Thyro-Tabs® Canine (levothyroxine sodium tablets), USP

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Thyro-Tabs® Canine (levothyroxine sodium tablets), USP

WARNINGS:

Thyro-Tabs® Canine (levothyroxine sodium tablets), USP

ADVERSE REACTIONS:

Thyro-Tabs® Canine (levothyroxine sodium tablets), USP

Administer by mouth 0.1 mg/10 pounds of body weight (0.022 mg/kilogram) as a single dose every 24 hours or as a divided dose every 12 hours.

Oral

For oral use in dogs only. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Thyro-Tabs® Canine

The initial dose is 0.1 mg/10 lb (0.01 mg/lb, 0.022 mg/kg) body weight twice daily.

Oral

ThyroKare™

DOSAGE AND ADMINISTRATION: The initial total daily dose is 0.1 mg/10 pounds (0.01 mg/lb; 0.022 mg/kg) body weight as a single dose every 24 hours or as a divided dose every 12 hours. The dose may then be adjusted by monitoring the serum total thyroxine (TT4) concentrations 4 to 6 hours post-tablet administration, along with clinical response, of the dog every 4 to 8 weeks until an adequate maintenance dose is established. To minimize day-to-day variations in serum TT4 concentrations (see CLINICAL PHARMACOLOGY), owners should consistently administer Thyro-Tabs Canine either with or without food. When switching from another levothyroxine sodium formulation to Thyro-Tabs Canine, monitor serum TT4 concentrations and clinical response due to potential differences in recommended starting doses and potential differences in bioavailability.

ORAL

Thyro-Tabs® Canine (levothyroxine sodium tablets), USP

Doses should be individualized and animals should be monitored daily for clinical signs of hyperthyroidism or hypersensitivity. Suggested initial doses are 1–10 mg levothyroxine sodium (T4)/100 lb. body weight (2–20 mg/100 kg) once per day or in divided doses. Response to the administration of Thyrozine Powder should be evaluated clinically every week until an adequate maintenance dose is established. In most horses, this is usually in the range of 35 to 100 mg total daily dose of T4 (1–3 level tablespoonfuls Thyrozine Powder).

ORAL

Thyrozine Powder