Androgen Receptor Agonists

The androgen receptor is a ligand-activated steroid hormone receptor that acts as a transcription factor: bound by its steroid it works at androgen response elements on target genes, with coactivators and corepressors - ZBTB7A recruiting NCOR1 and NCOR2, for instance - tuning the response, and so regulates proliferation and differentiation in androgen-responsive tissue. Drugs in this class activate it, reproducing the effects of endogenous androgens. A drug belongs here because it is an agonist at the androgen receptor; as MED-RT populates the class that covers testosterone and its esters, the anabolic steroids stanozolol, oxandrolone, oxymetholone, methandrostenolone, methyltestosterone and nandrolone, and danazol.