chloramphenicol

Oral treatment of bacterial pulmonary infections, bacterial infections of the urinary tract, bacterial enteritis, and bacterial infections associated with canine distemper caused by susceptible organisms.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Chloromycetin Tablets 100 mg

Treatment of bacterial pulmonary infections, infections of the urinary tract, enteritis, and infections associated with canine distemper that are caused by organisms susceptible to chloramphenicol.

Not for use in animals that are raised for food production. Must not be used in meat, egg, or milk-producing animals. The length of time that residues persist in milk or tissues has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Chloromycetin Palmitate Oral Suspension

Oral treatment of bacterial gastroenteritis associated with bacterial diarrhea, bacterial pulmonary infections, and bacterial infections of the urinary tract caused by susceptible organisms.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Viceton® Tablets

Treatment of infections of the respiratory tract, the urinary tract, and enteritis and tonsillitis caused by organisms susceptible to chloramphenicol.

Not for use in animals raised for food production. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Tevcocin

Treatment of bacterial conjunctivitis and ocular inflammation caused by organisms susceptible to chloramphenicol.

For use only by or on the order of a licensed veterinarian.

Chlorasone Ophthalmic Ointment

Treatment of bacterial conjunctivitis caused by pathogens susceptible to chloramphenicol.

Continue treatment for 48 hours (2 days) after the eye appears normal. If improvement is not noted in a few days a change of therapy should be considered. When infection is suspected as the cause of a disease process, especially in purulent or catarrhal conjunctivitis, attempts should be made to determine through susceptibility testing, which antibiotics will be effective prior to applying ophthalmic preparations. This chloramphenicol product must not be used in animals producing meat, eggs or milk. The length of time that residues persist in milk or tissues has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Chloromycetin Ophthalmic Ointment

Treatment of bacterial conjunctivitis and ocular inflammation caused by organisms susceptible to chloramphenicol.

For use only by or on the order of a licensed veterinarian.

Chlorasone Ophthalmic Ointment

Treatment of bacterial conjunctivitis caused by pathogens susceptible to chloramphenicol.

Continue treatment for 48 hours (2 days) after the eye appears normal. Therapy for cats should not exceed 7 days. Prolonged use in cats may produce blood dyscrasias. If improvement is not noted in a few days a change of therapy should be considered. When infection is suspected as the cause of a disease process, especially in purulent or catarrhal conjunctivitis, attempts should be made to determine through susceptibility testing, which antibiotics will be effective prior to applying ophthalmic preparations. This chloramphenicol product must not be used in animals producing meat, eggs or milk. The length of time that residues persist in milk or tissues has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Chloromycetin Ophthalmic Ointment

INDICATIONS: Chloramphenicol Tablets are recommended for oral treatment of the following conditions in dogs: Bacterial pulmonary infections caused by susceptible microorganisms such as: Staphylococcus aureus, Streptococcus pyogenes and Brucella bronchiseptica. Infections of the urinary tract caused by susceptible microorganisms such as: Escherichia coli, Proteus vulgaris, Corynebacterium renale, Streptococcus spp., and hemolytic Staphylococcus. Enteritis caused by susceptible microorganisms such as: E. coli, Proteus spp., Salmonella spp., and Pseudomonas spp. Infections associated with canine distemper caused by susceptible microorganisms such as: B. bronchiseptica, E. coli, P. aeruginosa, Proteus spp., Shigella spp. and Neisseria catarrhalis. Additional adjunctive therapy should be used when indicated. Most susceptible infectious disease organisms will respond to chloramphenicol therapy in three to five days when the recommended dosage regimen is followed. If no response to chloramphenicol therapy is obtained in three to five days, discontinue its use and review the diagnosis. Also, a change of therapy should be considered. Laboratory tests should be conducted including in vitro culturing and susceptibility tests on samples collected prior to treatment.

FDA application 055-059

CONTRAINDICATIONS: Because of potential antagonism, chloramphenicol should not be administered simultaneously with penicillin or streptomycin.

FDA application 055-059

HAZARDS AND PRECAUTIONS: This antibiotic contains a chemical structure (nitrobenzene group) that is characteristic of a group of drugs long known to depress hematopoietic activity of the bone marrow (54). In vitro-tissue culture studies using canine bone marrow cells have demonstrated that extremely high concentrations of chloramphenicol inhibit both uptake of iron by the nucleated red cells and incorporation of iron into heme (55). Chloramphenicol products should not be administered in conjunction with or two hours prior to the induction of general anesthesia with pentobarbitol because of prolonged recovery time. Chloramphenicol products should not be administered to dogs maintained for breeding purposes. Some experiments indicate that chloramphenicol causes, in experimental animals, particularly females, significant disorders in morphology as well as in function of the gonads.

FDA application 055-059

WARNING: NOT FOR USE IN ANIMALS WHICH ARE RAISED FOR FOOD PRODUCTION. CHLORAMPHENICOL PRODUCTS SHOULD NOT BE ADMINISTERED IN CONJUNCTION WITH OR 2 HOURS PRIOR TO THE INDUCTION OF GENERAL ANESTHESIA WITH PENTOBARBITAL BECAUSE OF PROLONGED RECOVERY. CHLORAMPHENICOL SHOULD NOT BE ADMINISTERED TO DOGS MAINTAINED FOR BREEDING PURPOSES. SOME EXPERIMENTS INDICATE THAT CHLORAMPHENICOL CAUSES IN EXPERIMENTAL ANIMALS, PARTICULARLY IN FEMALES, SIGNIFICANT DISORDERS IN MORPHOLOGY AS WELL AS IN FUNCTION OF THE GONADS.

FDA application 055-059

Keep out of reach of children.

FDA application 055-059

ADVERSE REACTIONS: Certain individual dogs may exhibit transient vomiting or diarrhea after an oral dose of 25 mg/lb body weight (49). The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-88-FDA-VETS or online at www.fda.gov/reportanimalae.

FDA application 055-059

Apply every 3 hours around the clock for 48 hours after which night installations may be omitted. Apply 4 to 6 times daily to affected eye for the first 72 hours depending upon the severity of the condition. A small amount of ointment should be placed in the conjunctival sac.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Federal law prohibits the use of this drug in food-producing animals.

Chloricol

5 to 15 milligrams per pound of body weight, intramuscularly or intravenously, every 6 hours. In severe infections, use 4 to 6 hours treatment intervals the first day. If no response is obtained in 3 to 5 days, discontinue use and reevaluate diagnosis.

Intravenous, Intramuscular

Not for use in animals raised for food production. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Mychel-Vet Injection

Apply one or two drops 4 to 6 times a day for the first 72 hours, depending on the severity of the condition. Intervals between applications may be increased after the first 2 days.

Ophthalmic

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Chlorasol

4 to 6 times daily to the affected eye for the first 72 hours depending upon the severity of the condition. Continue treatment for 48 hours after the eye appears normal.

Ophthalmic

For use only by or on the order of a licensed veterinarian.

Chlorasone Ophthalmic Ointment

25 milligrams per pound of body weight every 6 hours. If no response is obtained in 3 to 5 days, discontinue use and reevaluate diagnosis.

Oral

Not for use in animals that are raised for food production. Must not be used in meat, egg, or milk-producing animals. The length of time that residues persist in milk or tissues has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Chloromycetin Palmitate Oral Suspension

Administer 25 mg per pound of body weight by mouth every 6 hours.

Oral

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Federal law prohibits the extralabel use of this drug in food-producing animals.

Mychel-Vet Tabs

25 milligrams per pound of body weight every 6 hours.

Oral

Laboratory tests should be conducted including in vitro culturing and susceptibility tests on samples collected prior to treatment. This product must not be used in meat-, egg-, or milk-producing animals. The length of time that residues persist in milk or tissues has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Chloramphenicol Capsules

Apply every 3 hours around the clock for 48 hours after which night installations may be omitted. Apply 4 to 6 times daily to affected eye for the first 72 hours depending upon the severity of the condition. A small amount of ointment should be placed in the conjunctival sac.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Federal law prohibits the use of this drug in food-producing animals.

Chloricol

Apply one or two drops 4 to 6 times a day for the first 72 hours, depending on the severity of the condition. Intervals between applications may be increased after the first 2 days.

Ophthalmic

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Chlorasol

4 to 6 times daily to the affected eye for the first 72 hours depending upon the severity of the condition. Continue treatment for 48 hours after the eye appears normal.

Ophthalmic

For use only by or on the order of a licensed veterinarian.

Chlorasone Ophthalmic Ointment

DOSAGE AND ADMINISTRATION: Dogs-25 mg/lb body weight every 6 hours for oral administration.

ORAL

FDA application 055-059