fluocinolone acetonide

The drug is indicated for the relief of pruritus and inflammation associated with certain superficial acute and chronic dermatoses in dogs. It is used in the treatment of allergic and acute moist dermatitis and for the relief of superficial inflammation caused by chemical and physical abrasions and burns.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Synalar® Cream Veterinary

The drug is used in the relief of pruritus and inflammation associated with superficial acute and chronic dermatoses in dogs. It is used in the treatment of such conditions as allergic and acute moist dermatoses and nonspecific dermatoses in dogs. It is used in the treatment of wound infections in dogs.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Neo-synalar Cream

The drug is used in dogs for the relief of impaction commonly present in apparently normal anal sacs for the reversal of inflammatory changes associated with abnormal anal sacs, and to counteract the offensive odor of anal sac secretions.

For use only by or on the order of a licensed veterinarian.

Synsac Solution

The drug is indicated for the relief of pruritus and inflammation associated with otitis externa and certain superficial acute and chronic dermatoses in the dog.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Synalar® Solution Veterinary

The drug is used in dogs for the relief of pruritis and inflammation associated with acute and chronic otitis.

Synotic® Otic Solution

The drug is indicated for the relief of pruritus and inflammation associated with acute otitis externa and certain superficial acute and chronic dermatoses in the cat.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Synalar® Solution Veterinary

It is used in the treatment of wound infections in cats.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Neo-synalar Cream

SYNOTIC Otic Solution Veterinary is indicated for the relief of pruritus and inflammation associated with acute and chronic otitis in the dog.

Synotic® Otic Solution

Fluocinolone acetonide is chemically related to prednisolone and possesses marked anti-inflammatory properties when applied topically. It has been shown to have over 100 times the anti-inflammatory activity of hydrocortisone. Fluocinolone acetonide decreases edema, inflammation, erythema, infiltration and pruritus with its associated scratching and excoriation. Following topical application of fluocinolone acetonide, especially at elevated dosage levels, systemic effects such as some adrenal suppression and weight loss have been observed. These effects, however, have been demonstrated to be reversible. It has been demonstrated in the human, by both in vivo and in vitro methods, that DMSO enhances the percutaneous absorption of various compounds including steroids, vasoconstrictors, antiperspirants and dyes, as well as an anthelmintic (thiabendazole) and a skin antiseptic (hexachlorophene) (1,2,3,4,5). It was also shown in immature female rats that both estrogens and corticoids applied topically in DMSO exerted some of their usual biological effects (6,7).

Synotic® Otic Solution

Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Additionally, corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Corticosteroids administered to dogs during pregnancy have also resulted in other congenital anomalies, including deformed forelegs, phocomelia and anasarca. .

Synotic® Otic Solution

The recommended dose of SYNOTIC Otic Solution Veterinary is 4 to 6 drops (0.2 mL) per ear administered twice daily into the ear canal for a maximum period of 14 days. The total dosage used should not exceed 17 mL. It is recommended that the affected ear canal be cleansed by some appropriate method prior to the instillation of the solution. Following instillation, gentle external massage of the ear canal may aid in promoting an even distribution of the medication. Care should be taken to avoid contact of the medication with the dog’s eyes. Contact of the bare hand with the medication should also be avoided. Hearing loss has been reported in a small number of dogs after use. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue use of Synotic® immediately and flush the ear canal thoroughly with a nonototoxic solution.

Topical

Synotic® Otic Solution

It is administered by instillation of 1 to 2 milliliters into each anal sac following expression of anal sac contents. It may be necessary to repeat treatment at 60-day intervals to maintain an odor-free state. The total dosage used should not exceed 2 milliliters per anal sac per treatment.

Topical

For use only by or on the order of a licensed veterinarian.

Synsac Solution

A small amount of solution is applied to the affected area 2 or 3 times daily.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Synalar® Solution Veterinary

A small amount is applied to the infected area two or three times daily.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Neo-synalar Cream

A small amount of solution is applied to the affected area 2 or 3 times daily.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Synalar® Solution Veterinary

A small amount is applied to the infected area two or three times daily.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Neo-synalar Cream

The recommended dose of SYNOTIC Otic Solution Veterinary is 4 to 6 drops (0.2 mL) per ear administered twice daily into the ear canal for a maximum period of 14 days. The total dosage used should not exceed 17 mL. It is recommended that the affected ear canal be cleansed by some appropriate method prior to the instillation of the solution. Following instillation, gentle external massage of the ear canal may aid in promoting an even distribution of the medication. Care should be taken to avoid contact of the medication with the dog’s eyes. Contact of the bare hand with the medication should also be avoided. Hearing loss has been reported in a small number of dogs after use. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue use of Synotic immediately and flush the ear canal thoroughly with a nonototoxic solution.

AURICULAR (OTIC)

Synotic® Otic Solution