The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.
Do not apply to irritated skin.
Remove the applicator from the outer pouch using scissors or fold along diagonal line to expose nick; tear back at nick. As specified in the following table, administer the entire contents of the Midamox for Dogs (imidacloprid and moxidectin) applicator that correctly corresponds with the body weight of the dog.
* Dogs over 110 lbs. should be treated with the appropriate combination of Midamox for Dogs applicators.
Dog (lbs.)
Midamox for Dogs
Volume (mL)
Imidacloprid (mg)
Moxidectin (mg)
3–9
Midamox 9
0.4
40
10
9.1–20
Midamox 20
1.0
100
25
20.1–55
Midamox 55
2.5
250
62.5
55.1–88
Midamox 88
4.0
400
100
88.1–110*
Midamox 110
5.0
500
125
Hold the applicator upright.
Tap the narrow part of the applicator to ensure the contents remain within the main body of the applicator.
Twist or snap back the tip.
The dog should be standing for application. Part the hair on the back of the dog between the shoulder blades until the skin is visible. For dogs weighing 20 lbs. or less, place the tip of the applicator on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. For dogs weighing more than 20 lbs., place the tip of the applicator on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Do not apply an amount of solution at any one location that could run off the side of the dog.
Do not let this product get in your dog's mouth or eyes. Do not allow the dog to lick any of the application sites for 30 minutes. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites.
(See WARNINGS.) Contact with eyes can lead to eye irritation and corneal ulceration. If contact with eyes occurs, hold the dog's eyelids open, flush thoroughly with water, and contact your veterinarian.
Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. This is temporary and does not affect the safety and effectiveness of the product.
Shampooing 90 minutes after treatment does not reduce the effectiveness of Midamox for Dogs in the prevention of heartworm disease. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Midamox for Dogs in the treatment of flea infestations. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas.
Heartworm Prevention: For prevention of heartworm disease, Midamox for Dogs should be administered at one-month intervals. Midamox for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. If a dose is missed and a 30-day interval between doses is exceeded, administer Midamox for Dogs immediately and resume the monthly dosing schedule. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Midamox for Dogs should be given within one month of the last dose of the former medication.
Treatment of Circulating Microfilaria: For the treatment of circulating D. immitis microfilaria in heartworm-positive dogs, Midamox for Dogs should be administered at one-month intervals. Treatment with an approved adulticide therapy is recommended because Midamox for Dogs is not effective for the treatment of adult D. immitis.
(See PRECAUTIONS.)
TOPICAL
Midamox® for Dogs(imidacloprid + moxidectin)Topical Solution
The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.
Do not apply to irritated skin.
Do not let this product get in your dog’s mouth or eyes.
Do not allow the dog to lick any of the application sites for 30 minutes.
In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites.
(See WARNINGS.)
Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. This is temporary and does not affect the safety and effectiveness of the product.
Shampooing 90 minutes after treatment does not reduce the effectiveness of PARASEDGE™ Multi for Dogs in the prevention of heartworm disease. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of PARASEDGE™ Multi for Dogs in the treatment of flea infestations. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas.
Heartworm Prevention: For prevention of heartworm disease, PARASEDGE™ Multi for Dogs should be administered at one-month intervals. PARASEDGE™ Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. If a dose is missed and a 30-day interval between doses is exceeded, administer PARASEDGE™ Multi for Dogs immediately and resume the monthly dosing schedule. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with PARASEDGE™ Multi for Dogs should be given within one month of the last dose of the former medication.
Treatment of Circulating Microfilaria: For the treatment of circulating D. immitis microfilaria in heartworm-positive dogs, PARASEDGE™ Multi for Dogs should be administered at one-month intervals. Treatment with an approved adulticide therapy is recommended because PARASEDGE™ Multi for Dogs is not effective for the treatment of adult D. immitis.
(See PRECAUTIONS.)
Flea Treatment: For the treatment of flea infestations, PARASEDGE™ Multi for Dogs should be administered at one-month intervals. If the dog is already infested with fleas when the first dose of PARASEDGE™ Multi for Dogs is administered, adult fleas on the dog will be killed. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. Dogs treated with imidacloprid, including those with pre-existing flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the dog.
Treatment and Control of Intestinal Nematode Infections:
For the treatment and control of intestinal hookworm infections caused by Ancylostoma caninum and Uncinaria stenocephala (adults, immature
adults and fourth stage larvae) and roundworm infections caused by Toxocara canis (adults and fourth stage larvae), and Toxascaris leonina (adults), and whipworm infections caused by Trichuris vulpis (adults), PARASEDGE™ Multi for Dogs should be administered once as a single topical dose.
Treatment and Control of Sarcoptic Mange: For the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis, PARASEDGE™ Multi for Dogs should be administered as a single topical dose. A second monthly dose may be administered if necessary.
TOPICAL
PARASEDGE™ Multi for Dogs(imidacloprid + moxidectin) Topical Solution
The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.
Do not apply to irritated skin.
As specified in the following table, administer the entire contents of the PARASEDGE™ Multi for Cats (10% imidacloprid + 1% moxidectin) tube that correctly corresponds with the body weight of the cat.
Do not get this product in the cat’s mouth or eyes or allow the cat to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming. In households with multiple pets, keep animals separated to prevent licking of the application site.
Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some cats. This is temporary and does not affect the safety and effectiveness of the product.
Heartworm Prevention: For prevention of heartworm disease, PARASEDGE™ Multi for Cats should be administered at one-month intervals. PARASEDGE™ Multi for Cats may be administered year-around or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. If a dose is missed and a 30-day interval between doses is exceeded, administer PARASEDGE™ Multi for Cats immediately and resume the monthly dosing schedule. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with PARASEDGE™ Multi for Cats should be given within one month of the last dose of the former medication. At the discretion of the veterinarian, cats older than 6 months of age may be tested to determine the presence of existing heartworm infection before treatment with PARASEDGE™ Multi for Cats (See ADVERSE REACTIONS Post-Approval Experience).
Flea Treatment: For the treatment of flea infestations, PARASEDGE™ Multi for Cats should be administered at one-month intervals. If the cat is already infested with fleas when the first dose of PARASEDGE™ Multi for Cats is administered, adult fleas on the cat will be killed. However, re-infestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. Cats treated with imidacloprid, including those with pre-existing flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the cat.
Ear Mite Treatment: For the treatment of ear mites (Otodectes cynotis), PARASEDGE™ Multi for Cats should be administered once as a single topical dose. Monthly use of PARASEDGE™ Multi for Cats will control any subsequent ear mite infestations.
Intestinal Nematode Treatment: For the treatment and control of intestinal hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara cati (adults and fourth stage larvae), PARASEDGE™ Multi for Cats should be administered once as a single topical dose.
TOPICAL
PARASEDGE™ Multi for Cats(imidacloprid + moxidectin)Topical Solution
Credelio Quattro/Credelio Quattro-CA1 is given orally at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Credelio Quattro/Credelio Quattro-CA1 must be administered with food (see
Clinical Pharmacology
). Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If vomiting occurs within an hour after administration, readminister a new dose of Credelio Quattro/Credelio Quattro-CA1.
Credelio Quattro:
Credelio Quattro is given once a month. If a dose is missed, give Credelio Quattro immediately and resume a monthly dosing schedule.
Dosing Schedule:
*As pamoate salt
Body Weight (lbs)
Tablets to Administer
Lotilaner
per Tablet (mg)
Moxidectin
per Tablet (mg)
Praziquantel
per Tablet (mg)
Pyrantel*
per Tablet (mg)
3.3 – 6
1
56.25
0.056
14.25
14.25
6.1 – 12
1
112.5
0.113
28.5
28.5
12.1 – 25
1
225
0.225
57
57
25.1 – 50
1
450
0.45
114
114
50.1 – 100
1
900
0.9
228
228
> 100
Administer the appropriate combination of tablets
Heartworm Prevention
Credelio Quattro should be administered year-round at monthly intervals or at least within 1 month of the animal’s first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog’s last seasonal exposure. If a dose is missed, give Credelio Quattro immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, Credelio Quattro should be given within 1 month of the last dose of the former medication.
Intestinal Nematode and Cestode Treatment and Control
Credelio Quattro should be administered as a single dose for the treatment of roundworm, hookworm, and tapeworm infections. Monthly use of Credelio Quattro will control any subsequent infections. Dogs may be exposed to and can become infected with gastrointestinal worms throughout the year, regardless of season or climate. Clients should be advised of appropriate measures to prevent reinfection of their dog with intestinal parasites.
Flea Treatment and Prevention
Treatment with Credelio Quattro should be administered year-round at monthly intervals or started at least 1 month before fleas become active. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.
Tick Treatment and Control
Treatment with Credelio Quattro can begin at any time of the year. Credelio Quattro should be administered year-round at monthly intervals or started at least 1 month before ticks become active.
Credelio Quattro-CA1:
New World Screwworm (NWS) Myiasis Treatment
A single dose of Credelio Quattro-CA1 is reasonably expected to treat C. hominivorax present at the time of treatment. Re-infestation with C. hominivorax may occur sooner than one month. Treatment should be used in conjunction with the mechanical removal of larvae (live and dead) remaining in the wound after treatment (see
PRECAUTIONS
).
ORAL
Credelio Quattro™ CredelioQuattro™-CA1(lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets)
The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.
Do not apply to irritated skin.
1.Remove one dose applicator tube from the package. As specified in the following table, administer the entire contents of the Advantage Multi for Dogs tube that correctly corresponds with the body weight of the dog.
* Dogs over 110 lbs. should be treated with the appropriate combination of Advantage Multi for Dogs tubes.
Dog (lbs.)
Advantage
Multi For Dogs
Volume (mL)
Imidacloprid (mg)
Moxidectin (mg)
3–9
Advantage Multi 9
0.4
40
10
9.1–20
Advantage Multi 20
1.0
100
25
20.1–55
Advantage Multi 55
2.5
250
62.5
55.1–88
Advantage Multi 88
4.0
400
100
88.1–110*
Advantage Multi 110
5.0
500
125
2.While holding the tube in an upright position, remove the cap from the tube.
3.Turn the cap over and push the other end of cap onto the tip of the tube.
4.Twist the cap to break the seal and then remove cap from the tube.
5.The dog should be standing for application. Part the hair on the back of the dog between the shoulder blades until the skin is visible. For dogs weighing 20 lbs. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Do not apply an amount of solution at any one location that could run off the side of the dog.
Do not let this product get in your dog's mouth or eyes. Do not allow the dog to lick any of the application sites for 30 minutes. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites. (See WARNINGS.) Contact with eyes can lead to eye irritation and corneal ulceration. If contact with eyes occurs, hold the dog’s eyelids open, flush thoroughly with water, and contact your veterinarian.
Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. This is temporary and does not affect the safety and effectiveness of the product.
Shampooing 90 minutes after treatment does not reduce the effectiveness of Advantage Multi for Dogs in the prevention of heartworm disease. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Advantage Multi for Dogs in the treatment of flea infestations. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas.
TOPICAL
Elanco TM advantage multi™ for dogs (imidacloprid+moxidectin) Topical Solution
The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration. Do not apply to irritated skin.
Remove the applicator from the outer pouch using scissors or fold along diagonal line to expose nick; tear back at nick. As specified in the following table, administer the entire contents of the Midamox for Dogs (imidacloprid and moxidectin) applicator that correctly corresponds with the body weight of the dog.
* Dogs over 110 lbs. should be treated with the appropriate combination of Midamox for Dogs applicators.
Dog (lbs.)
Midamox for Dogs
Volume (mL)
Imidacloprid (mg)
Moxidectin (mg)
3–9
Midamox 9
0.4
40
10
9.1–20
Midamox 20
1.0
100
25
20.1–55
Midamox 55
2.5
250
62.5
55.1–88
Midamox 88
4.0
400
100
88.1–110*
Midamox 110
5.0
500
125
Hold the applicator upright.
Tap the narrow part of the applicator to ensure the contents remain within the main body of the applicator.
Twist or snap back the tip.
The dog should be standing for application. Part the hair on the back of the dog between the shoulder blades until the skin is visible. For dogs weighing 20 lbs. or less, place the tip of the applicator on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. For dogs weighing more than 20 lbs., place the tip of the applicator on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Do not apply an amount of solution at any one location that could run off the side of the dog.
Do not let this product get in your dog's mouth or eyes. Do not allow the dog to lick any of the application sites for 30 minutes. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites.
(See WARNINGS.) Contact with eyes can lead to eye irritation and corneal ulceration. If contact with eyes occurs, hold the dog's eyelids open, flush thoroughly with water, and contact your veterinarian.
Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. This is temporary and does not affect the safety and effectiveness of the product.
Shampooing 90 minutes after treatment does not reduce the effectiveness of Midamox for Dogs in the prevention of heartworm disease. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Midamox for Dogs in the treatment of flea infestations. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas.
TOPICAL
VETone ® Midamox ® for Dogs (imidacloprid + moxidectin)
SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 μg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt).
Dosage Schedule
Body Weight
(lbs)
Sarolaner per
Tablet
(mg)
Moxidectin
per Tablet
(mg)
Pyrantel
per
Tablet
(mg)
Number
of Tablets
Administered
2.8 to 5.5
3
0.06
12.5
One
5.6 to 11.0
6
0.12
25
One
11.1 to 22.0
12
0.24
50
One
22.1 to 44.0
24
0.48
100
One
44.1 to 88.0
48
0.96
200
One
88.1 to 132.0
72
1.44
300
One
>132.0
Administer the appropriate combination of tablets
SIMPARICA TRIO can be offered to the dog with or without food.
Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing.
Heartworm Prevention:
SIMPARICA TRIO should be administered at monthly intervals year‑round or at least within one month of the animal’s first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog’s last seasonal exposure. If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, SIMPARICA TRIO should be given within one month of the last dose of the former medication.
Flea Treatment and Prevention:
Treatment with SIMPARICA TRIO may begin at any time of the year. SIMPARICA TRIO should be administered year‑round at monthly intervals or started at least one month before fleas become active.
To minimize the likelihood of flea re‑infestation, it is important to treat all dogs and cats within a household with a flea control product.
Tapeworm Prevention:
Treatment with SIMPARICA TRIO may begin at any time of the year. SIMPARICA TRIO should be administered year-round at monthly intervals or started at least one month before fleas become active.
SIMPARICA TRIO will only prevent D. caninum infections by killing the fleas on the treated dog. Dogs may also become infected with D. caninum by ingesting fleas from untreated animals, it is therefore recommended that all pets in a household are treated for fleas.
Tick Treatment and Control:
Treatment with SIMPARICA TRIO can begin at any time of the year. SIMPARICA TRIO should be administered year‑round at monthly intervals or started at least one month before ticks become active.
Intestinal Nematode Treatment and Control:
For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections, SIMPARICA TRIO should be administered once as a single dose. Monthly use of SIMPARICA TRIO will control any subsequent infections.
ORAL
Simparica TRIO®
The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.
Do not apply to irritated skin.
1. Remove one dose applicator tube from the package. As specified in the following table, administer the entire contents of the IMOXI™ Topical Solution for Dogs tube that correctly corresponds with the body weight of the dog.
Dog (lbs.)
Volume (mL)
Imidacloprid (mg)
Moxidectin (mg)
3–9
0.4
40
10
9.1–20
1.0
100
25
20.1–55
2.5
250
62.5
55.1–88
4.0
400
100
88.1–110 Dogs over 110 lbs. should be treated with the appropriate combination of IMOXI™ Topical Solution for Dogs tubes.
5.0
500
125
2. While holding the Twist•N•Go™ tube in an upright position, twist the dispensing cap clockwise about ½ turn to break the tube's seal. Remove the cap from the tube.
3. The dog should be standing for application. Position the dispensing tip on the dog's back between the shoulder blades. The dispensing tip of the tube can be used to part the dog's hair until the skin is visible.
4. For dogs weighing 20 lbs. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Do not apply an amount of solution at any one location that could run off the side of the dog.
Do not let this product get in your dog's mouth or eyes. Do not allow the dog to lick any of the application sites for 30 minutes. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites.
(See WARNINGS) Contact with eyes can lead to eye irritation and corneal ulceration. If contact with eyes occurs, hold the dog's eyelids open, flush thoroughly with water, and contact your veterinarian.
Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. This is temporary and does not affect the safety and effectiveness of the product.
Shampooing 90 minutes after treatment does not reduce the effectiveness of IMOXI™ Topical Solution for Dogs in the prevention of heartworm disease. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of IMOXI™ Topical Solution for Dogs in the treatment of flea infestations. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas.
TOPICAL
IMOXI™ Topical Solution for Dogs (imidacloprid + moxidectin)
The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.
Do not apply to irritated skin.
Remove one dose applicator tube from the package. As specified in the following table, administer the entire contents of the Barrier for Dogs (imidacloprid + moxidectin) tube that correctly corresponds with the body weight of the dog.
* Dogs over 110 lbs. should be treated with the appropriate combination of Barrier for Dogs tubes.
Dog (lbs.)
Volume (mL)
Imidacloprid (mg)
Moxidectin (mg)
3–9
0.4
40
10
9.1–20
1.0
100
25
20.1–55
2.5
250
62.5
55.1–88
4.0
400
100
88.1–110*
5.0
500
125
While holding the tube in an upright position, twist the cap to break the seal and apply. The cap will remain on the tube.
3. The dog should be standing for application. Part the hair on the back of the dog between the shoulder blades until the skin is visible. For dogs weighing 20 lbs. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Do not apply an amount of solution at any one location that could run off the side of the dog.
Do not let this product get in your dog's mouth or eyes. Do not allow the dog to lick any of the application sites for 30 minutes. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites. (See WARNINGS.)
Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. This is temporary and does not affect the safety and effectiveness of the product.
Shampooing 90 minutes after treatment does not reduce the effectiveness of Barrier for Dogs in the prevention of heartworm disease.
Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Barrier for Dogs in the treatment of flea infestations. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas.
TOPICAL
Barrier® for Dogs(imidacloprid+moxidectin)Topical Solution
Bravecto Plus should be administered topically as a single dose every 2 months according to the Dosage Schedule below to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin.
For prevention of heartworm disease, Bravecto Plus should be administered at 2-month intervals. Bravecto Plus may be administered year-round without interruption or at a minimum should be administered at 2-month intervals beginning at the cat's first seasonal exposure to mosquitoes and continuing until the cat's last seasonal exposure to mosquitoes. If a dose is missed and a 2-month interval between doses is exceeded, administer Bravecto Plus immediately and resume the dosing every 2 months.
When replacing a monthly heartworm preventative product, the first dose of Bravecto Plus should be given within one month of the last dose of the former medication.
Dosing Schedule:
Body Weight Ranges (lb)
Fluralaner content
(mg/tube)
Moxidectin content
(mg/tube)
Tubes Administered
2.6 – 6.2
112.5
5.6
One
>6.2 – 13.8
250
12.5
One
>13.8 – 27.5Cats over 27.5 lb should be administered the appropriate combination of tubes.
500
25
One
A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Bravecto Plus topically to cats prior to first use.
Step 1: Immediately before use, open the pouch and remove the tube. Put on gloves. Hold the tube at the crimped end with the cap in an upright position (tip up). The cap should be rotated clockwise or counter clockwise one full turn. The cap is designed to stay on the tube for dosing and should not be removed. The tube is open and ready for application when a breaking of the seal is felt.
Step 2: The cat should be standing or lying with its back horizontal during application. Part the fur at the administration site. Place the tube tip vertically against the skin at the base of the skull of the cat.
Step 3: Squeeze the tube and gently apply the entire contents of Bravecto Plus directly to the skin at the base of the skull of the cat. Avoid applying an excessive amount of solution that could cause some of the solution to run and drip off of the cat. If a second spot is needed to avoid run off, then apply the second spot slightly behind the first spot.
Greasy, oily, or wet appearance may occur at the application site in some cats.
TOPICAL
BRAVECTO® PLUS (fluralaner and moxidectin topical solution) for Cats
Dosage: MoxiSolv Pour-On (moxidectin) is a ready-to-use topical formulation intended for direct application to the hair and skin in a narrow strip extending along the top of the back from the withers to the tailhead (see Figure 1). Due to the angular topline characteristic of most dairy breeds, it is recommended that all pour on products be applied slowly to dairy cows. Apply to healthy skin avoiding any mange scabs, skin lesions, mud or manure. Treated cattle can be easily recognized by the characteristic purple color, which will remain for a short period of time after treatment. The recommended rate of administration is 1 mL for each 22 lb (10 kg) body weight which provides 0.5 mg moxidectin for each 2.2 lb (0.5 mg/kg) body weight. The table below will assist in the calculation of the appropriate volume of pour-on which must be applied based on the weight of animal being treated.
Figure 1. Where to Apply MoxiSolv Pour-On
Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.
Use Conditions: Varying weather conditions, including rainfall, do not affect the efficacy of MoxiSolv Pour-On.
Administration: MoxiSolv Pour-On is available in two convenient package styles designed for ease of administration and the number of cattle to be treated. Directions for use of each container type follow:
Large Conventional Containers (169 fl oz/5 L Bottles and 338 fl oz/10 L Cubetainer)
These bottles are designed for use with most commercially-available applicators. Simply remove the transient cap and seal and replace with the vented cap. Attach the applicator feeder hose to the vented cap. Invert the container prior to use (5 L containers only). Apply the recommended volume of MoxiSolv Pour-On evenly along the backline of the animal from the withers to the tailhead (see Figure 1).
TOPICAL
FDA application 200-845
The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.
Do not apply to irritated skin.
1. Remove one dose applicator tube from the package. As specified in the following table, administer the entire contents of the Barrier for Cats tube that correctly corresponds with the body weight of the cat.
* Cats over 18 lbs. should be treated with the appropriate combination of Barrier for Cats tubes.
Cat (lbs.)
Volume (mL)
Imidacloprid (mg)
Moxidectin (mg)
2–5
0.23
23
2.3
5.1–9
0.4
40
4
9.1–18*
0.8
80
8
2. While holding the tube in an upright position, twist the cap to break the seal and then apply. The cap will remain on the tube.3.Part the hair on the back of the cat’s neck at the base of the head, until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin. Lift tube away from skin before releasing pressure on tube.
3. Part the hair on the back of the cat’s neck at the base of the head, until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin. Lift tube away from skin before releasing pressure on tube.
Do not get this product in the cat's mouth or eyes or allow the cat to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming. In households with multiple pets, keep animals separated to prevent licking of the application site.
Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some cats. This is temporary and does not affect the safety and effectiveness of the product.
TOPICAL
Barrier® for Cats (imidacloprid+moxidectin) Topical Solution
The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.
Do not apply to irritated skin.
1. Remove the applicator from the outer pouch using scissors or fold along diagonal line to expose nick; tear back at nick. As specified in the following table, administer the entire contents of the Midamox for Cats (imidacloprid and moxidectin) applicator that correctly corresponds with the body weight of the cat.
* Cats over 18 lbs. should be treated with the appropriate combination of Midamox for Cats applicators.
Cat (lbs.)
Midamox for Cats
Volume (mL)
Imidacloprid (mg)
Moxidectin (mg)
2–5
Midamox 5
0.23
23
2.3
5.1–9
Midamox 9
0.4
40
4
9.1–18*
Midamox 18
0.8
80
8
Hold the applicator upright.
Tap the narrow part of the applicator to ensure the contents remain within the main body of the applicator.
Twist or snap back the tip.
Part the hair on the back of the cat's neck at the base of the head in front of the shoulder blades, until the skin is visible. Place the tip of the applicator on the skin and squeeze the applicator several times to empty its contents completely and directly onto the skin in one spot.
Do not get this product in the cat's mouth or eyes or allow the cat to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming. In households with multiple pets, keep animals separated to prevent licking of the application site.
Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some cats. This is temporary and does not affect the safety and effectiveness of the product.
TOPICAL
VETone®Midamox ® for Cats (imidacloprid + moxidectin)
The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.
Do not apply to irritated skin.
1.Remove one dose applicator tube from the package. As specified in the following table, administer the entire contents of the Advantage Multi for Cats tube that correctly corresponds with the body weight of the cat.
* Cats over 18 lbs. should be treated with the appropriate combination of Advantage Multi for Cats tubes.
Cat (lbs.)
Advantage
Multi
For Cats
Volume (mL)
Imidacloprid
(mg)
Moxidectin
(mg)
2–5
Advantage
Multi 5
0.23
23
2.3
5.1–9
Advantage
Multi 9
0.4
40
4
9.1–18*
Advantage
Multi 18
0.8
80
8
2.While holding the tube in an upright position, remove the cap from the tube.
3.Turn the cap over and push the other end of cap onto the tip of the tube.
4.Twist the cap to break the seal and then remove cap from the tube.
5.Part the hair on the back of the cat's neck at the base of the head, until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin. Lift tube away from skin before releasing pressure on tube.
Do not get this product in the cat's mouth or eyes or allow the cat to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming. In households with multiple pets, keep animals separated to prevent licking of the application site.
Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some cats. This is temporary and does not affect the safety and effectiveness of the product.
TOPICAL
Elanco TM advantage multi™ for cats (imidacloprid+moxidectin) Topical Solution
DOSAGE AND ADMINISTRATION:
The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.
Do not apply to irritated skin.
1. Remove one dose applicator tube from the package. As specified in the following table, administer the entire contents of the IMOXI™ Topical Solution for Cats tube that correctly corresponds with the body weight of the cat.
Cat (lbs.)
Volume (mL)
Imidacloprid (mg)
Moxidectin (mg)
2-5
0.23
23
2.3
5.1-9
0.4
40
4
9.1-18Cats over 18 lbs. should be treated with the appropriate combination of IMOXI™ Topical Solution for Cats tubes.
0.8
80
8
2. While holding the Twist•N•Go™ tube in an upright position, twist dispensing tip clockwise about ½ turn to break the tube's seal. Remove the cap from the tube.
3. Part the hair on the back of the cat's neck at the base of the head, until the skin is visible.
4. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin. Lift the tube away from the skin before releasing pressure on the tube.
Do not get this product in the cat's mouth or eyes or allow the cat to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming. In households with multiple pets, keep animals separated to prevent licking of the application site.
Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some cats. This is temporary and does not affect the safety and effectiveness of the product.
TOPICAL
IMOXI™ Topical Solution for Cats (imidacloprid + moxidectin)
DOSAGE
The recommended rate of administration for MoxiSolv Injection is 1 mL for each 110 lb (50 kg) body weight to provide 0.2 mg moxidectin/2.2 lb (0.2 mg/kg) body weight. The table below will assist in the calculation of the appropriate volume of injectable which must be administered based on the weight of animal being treated. Be careful not to overdose animals; estimate animal's body weight as closely as possible or weigh animals individually.
Weight (lb)
165
220
330
440
550
660
770
880
990
1100
Weight (kg)
75
100
150
200
250
300
350
400
450
500
Dose (mL)
1.5
2.0
3.0
4.0
5.0
6.0
7.0
8.0
9.0
10.0
Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.
ADMINISTRATION
MoxiSolv Injection should be administered by subcutaneous injection under the loose skin in front of or behind the shoulder (Figure 1). Needles 1/2 to 3/4 inch in length and 16 to 18 gauge are recommended for subcutaneous injections. Use sterile, dry equipment and aseptic procedures when withdrawing and administering MoxiSolv.
Figure 1. Sites for administration of MoxiSolv Injection
SUBCUTANEOUS
FDA application 200-788
The recommended rate of administration for CYDECTIN Injectable is 1 mL for each 110 lb (50 kg) body weight to provide 0.2 mg moxidectin/2.2 lb (0.2 mg/kg) body weight. The table below will assist in the calculation of the appropriate volume of injectable which must be administered based on the weight of animal being treated. Be careful not to overdose animals; estimate animal’s body weight as closely as possible or weigh animals individually.
Weight (lb)
165
220
330
440
550
660
770
880
990
1100
Weight (kg)
75
100
150
200
250
300
350
400
450
500
Dose (mL)
1.5
2.0
3.0
4.0
5.0
6.0
7.0
8.0
9.0
10.0
•Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.
ADMINISTRATION
CYDECTIN Injectable should be administered by subcutaneous injection under the loose skin in front of or behind the shoulder (Figure 1). Needles 1/2 to 3/4 inch in length and 16 to 18 gauge are recommended for subcutaneous injections. Use sterile, dry equipment and aseptic procedures when withdrawing and administering CYDECTIN.
Figure 1. Sites for administration of CYDECTIN Injectable
SUBCUTANEOUS
FDA application 141-220
For ferrets:
The recommended minimum dose for a ferret is 9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.
Heartworm Prevention:
For prevention of heartworm disease, PARASEDGE Multi for Cats should be administered at one-month intervals. PARASEDGE Multi for Cats may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. If a dose is missed and a 30-day interval between doses is exceeded, administer PARASEDGE Multi for Cats immediately and resume the monthly dosing schedule.
Flea Treatment: For the treatment of flea infestations on ferrets, PARASEDGE Multi for Cats should be administered at one-month intervals. If the ferret is already infested with fleas when the first dose of PARASEDGE Multi for Cats is administered, adult fleas on the ferret will be killed. However, re-infestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated.
TOPICAL
PARASEDGE™ Multi for Cats(imidacloprid + moxidectin)Topical Solution
The recommended rate of administration for Durvet Moxidectin Oral Sheep Drench is 1 mL per 11 lb (5 kg) body weight to provide 0.2 mg moxidectin/2.2 lb (0.2 mg/kg) body weight. The table below will assist in the calculation of the appropriate volume of drench in 1.0 mL increments and it must be administered based on the weight of animal being treated.
Body Weight
Dose
Body Weight
Dose
Body Weight
Dose
11 lb
5 kg
1 mL
66 lb
30 kg
6 mL
121 lb
55 kg
11 mL
22 lb
10 kg
2 mL
77 lb
35 kg
7 mL
132 lb
60 kg
12 mL
33 lb
15 kg
3 mL
88 lb
40 kg
8 mL
143 lb
65 kg
13 mL
44 lb
20 kg
4 mL
99 lb
45 kg
9 mL
154 lb
70 kg
14 mL
55 lb
25 kg
5 mL
110 lb
50 kg
10 mL
165 lb
75 kg
15 mL
Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.
ORAL
Moxidectin ORAL SHEEP DRENCH™ (moxidectin)
The recommended rate of administration for Tauramox™ Injectable is 1 mL for each 110 lb (50 kg) body weight to provide 0.2 mg moxidectin/2.2 lb (0.2 mg/kg) body weight. The table below will assist in the calculation of the appropriate volume of injectable which must be administered based on the weight of animal being treated. Be careful not to overdose animals; estimate animal's body weight as closely as possible or weigh animals individually.
Weight (lb)
165
220
330
440
550
660
770
880
990
1100
Weight (kg)
75
100
150
200
250
300
350
400
450
500
Dose (mL)
1.5
2.0
3.0
4.0
5.0
6.0
7.0
8.0
9.0
10.0
Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.
SUBCUTANEOUS
Tauramox™(moxidectin)Injectable Solution for Beefand Nonlactating Dairy Cattle
QUEST PLUS Gel is specially formulated as a palatable gel which is easily administered to horses and ponies. QUEST PLUS Gel is packaged in ready-to-use SURE-DIAL® syringes. The syringe is calibrated in 50-pound increments, up to 1500 pounds. This enables the administration of the recommended dose level by choosing a setting consistent with the animal’s weight.
Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineff ective treatment, and encourage the development of parasite resistance.
ORAL
QUEST® PLUS GEL (moxidectin/praziquantel)
QUEST (moxidectin) 2% Equine Oral Gel is specially formulated as a palatable gel which is easily
administered to horses and ponies. QUEST Gel is packaged in ready-to-use SURE-DIAL® syringes. The
syringe is calibrated in 50-pound increments, up to 1500 pounds. This enables the administration of
the recommended dose level of 0.4 mg moxidectin/kg body weight by choosing a setting consistent
with the animal’s weight.
ORAL
QUEST® GEL (moxidectin)
Always provide Client Information Sheet and review with owners before administering ProHeart 12. The owner should be advised to observe their dog for adverse drug events including those described on the sheet. The Client Information Sheet is attached to this package insert and available online at http://www.proheart12.com for reprinting to provide to the owner.
SUBCUTANEOUS
ProHeart® 12 (moxidectin)For Extended-Release Injectable Suspension for Dogs
Durvet Moxidectin Oral Sheep Drench is ready-to-use. Administer 1 mL per 11 lb (1 mL per 5 kg) body weight into the mouth of the sheep, using any standard drenching equipment. Check dose rates and equipment before drenching. Do not overdose. Do not mix with any other products before administration. Avoid contaminating the drench solution.
ORAL
Moxidectin ORAL SHEEP DRENCH™ (moxidectin)
NexGard® PLUS is given orally once a month at the minimum dosage of 1.14 mg/lb (2.5 mg/kg) afoxolaner, 5.45 mcg/lb (12 mcg/kg) moxidectin, and 2.27 mg/lb (5.0 mg/kg) pyrantel (as pamoate salt).
For heartworm disease prevention, give once monthly for at least six months after last exposure to mosquitoes (see Effectiveness).
ORAL
NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets)
Always provide Client Information Sheet and review with owners before administering ProHeart 6. The owner should be advised to observe their dog for adverse drug events including those described on the sheet.
SUBCUTANEOUS
ProHeart® 6 (moxidectin)For Extended-Release Injectable Suspension for Dogs
CYDECTIN Pour-On is available in three convenient package styles designed for ease of administration and the number of cattle to be treated. Directions for use of each container type follow:
TOPICAL
FDA application 141-099