Cytochrome P450 2C19 Inducers

CYP2C19 is a cytochrome P450 monooxygenase that oxidises polyunsaturated fatty acids, inserting one atom of molecular oxygen into the substrate and reducing the second to water with two electrons supplied by NADPH through cytochrome P450 reductase. Drugs in this class induce it - UniProt records that this P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides and carcinogens - so a co-administered substrate of the pathway is cleared faster and its exposure falls. FDA grades that consequence and defines an inducer by it: strong and moderate index inducers decrease the AUC of sensitive substrates of a given metabolic pathway by at least 80 percent and by 50 to under 80 percent respectively. A drug belongs here because its recorded effect on CYP2C19 is induction, not inhibition; as MED-RT populates the class, its one member is mavacamten.