Gentamicin

For the treatment of otitis externa in dogs caused by susceptible strains of yeast (Malassezia pachydermatis) and bacteria (Pseudomonas spp. [including P. aeruginosa], coagulase- positive staphylococci, Enterococcus faecalis, Proteus mirabilis, and beta-hemolytic streptococci).

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Mometavet®

For the treatment of infections of urinary tract (cystitis, nephritis), respiratory tract (tonsillitis, pneumonia, tracheobronchitis), skin and soft tissue (pyodermatitis, wounds, lacerations, peritonitis).

If response is not noted after 7 days, the antibiotic sensitivity of the infecting organism should be retested. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Gentocin® Solution

For the treatment of otitis externa associated with susceptible strains of yeast (Malassezia pachydermatis) and bacteria (Staphylococcus pseudintermedius and Pseudomonas aeruginosa) in dogs.

Mometamax Single™

For the treatment of acute and chronic canine otitis externa associated with yeast (Malassezia pachydermatis, formerly Pityrosporum canis) and/or bacteria susceptible to gentamicin.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

GBC Ointment™

For the treatment of otitis externa in dogs associated with susceptible strains of yeast Malassezia pachydermatis and bacteria Staphylococcus pseudintermedius).

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For Otic Use in Dogs Only. Do not use in dogs with known tympanic membrane perforation.

Easotic®

For use in the treatment of urinary tract infections (cystitis) caused by Proteus mirabilis, Escherichia coli, and Staphylococcus aureus.

If no improvement is seen after 3 days treatment should be discontinued and the diagnosis reevaluated. Treatment not to exceed 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Gentamicin Sulfate Inj. Sol.

GENTOCIN® Ophthalmic Solution is indicated for topical treatment of conjunctivitis caused by susceptible bacteria in dogs and cats

Gentocin® Ophthalmic Solution

The drug is used in dogs in the treatment of infected superficial lesions caused by bacteria sensitive to gentamicin.

Federal law restricts this drug to use by or on the order of a licensed veterinarian

Gentamicin Sulfate Topical Spray

The drug is used or indicated for canine infected superficial lesions caused by bacteria sensitive to gentamicin.

If hypersensitivity to any of the components occurs, treatment should be discontinued and appropriate therapy instituted. Concomitant use of drugs known to induce ototoxicity should be avoided. Observe patients for signs of adrenocorticoid overdosage. The antibiotic susceptibility of the pathogenic organism should be determined prior to use of this preparation. Administration of recommended doses beyond 7 days may result in delayed wound healing. Animals treated longer than 7 days should be monitored closely. For use by or on the order of a licensed veterinarian.

Topagen® Ointment

The drug is used or indicated for use in dogs in the treatment of acute and chronic canine otitis externa.

If hypersensitivity to any of the components occurs, treatment should be discontinued and appropriate therapy instituted. Concomitant use of drugs known to induce ototoxicity should be avoided. Observe patients for signs of adrenocorticoid overdosage. The antibiotic susceptibility of the pathogenic organism should be determined prior to use of this preparation. Administration of recommended doses beyond 7 days may result in delayed wound healing. Animals treated longer than 7 days should be monitored closely. For use by or on the order of a licensed veterinarian.

Topagen® Ointment

For the treatment of acute and chronic otitis externa caused by bacteria sensitive to gentamicin in dogs.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Gentocin® Otic Solution

For the treatment of infected superficial lesions in dogs caused by bacteria susceptible to gentamicin.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

GB Topical Spray

For the treatment of canine superficial infected lesions caused by bacteria sensitive to gentamicin.

If hypersensitivity to any of the components occurs treatment with this product should be discontinued and appropriate therapy instituted. Concomitant use with other drugs known to induce ototoxicity is not recommended. This preparation should not be used in conditions where corticosteroids are contraindicated. Do not administer parenteral corticosteroids during treatment with this drug. The antibiotic sensitivity of the pathogenic organism should be determined prior to use of this preparation. For use by or on the order of a licensed veterinarian.

VET BETA-GEN®

The drug is used for topical treatment of conjunctivitis caused by susceptible bacteria.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Vetro-Gen™ Veterinary Ophthalmic Ointment

Swine (neonatal, 1 to 3 days of age)

For the control and treatment of colibacillosis in neonatal pigs 1-3 days of age, caused by strains of E. coli sensitive to gentamicin.

Gentamicin Sulfate Pig Pump Oral Solution

In piglets up to 3 days old for treatment of porcine colibacillosis caused by strains of E. coli sensitive to gentamicin.

For single intramuscular dose in pigs up to 3 days of age only. Do not slaughter treated animals for food for at least 40 days following treatment.

Garacin® Piglet Injection

In swine for control and treatment of swine dysentery associated with Brachyspira hyodysenteriae.

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. For use in swine drinking water only. Do not store or offer medicated drinking water in rusty containers since the drug is quickly destroyed in such containers. Medicated drinking water should be prepared daily and be the sole source of drinking water for 3 consecutive days. Treatment may be repeated if dysentery recurs. Do not slaughter treated swine for food for at least 3 days following treatment.

GENTORAL®

For the control and treatment of swine dysentery associated with Treponema hyodysenteriae.

For use in swine drinking water only. Do not store or offer medicated drinking water in rusty containers since the drug is quickly destroyed in such containers. Medicated drinking water should be prepared daily and be the sole source of drinking water. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

GentaMed™

Swine (weanling)

For the control and treatment of colibacillosis in weaning swine caused by strains of Escherichia coli sensitive to gentamicin.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

GentaMed™

Swine (weanling)

In weanling swine for control and treatment of colibacillosis caused by strains of E. coli sensitive to gentamicin.

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. For use in swine drinking water only. Do not store or offer medicated drinking water in rusty containers since the drug is quickly destroyed in such containers. Medicated drinking water should be prepared daily and be the sole source of drinking water for 3 consecutive days. Treatment may be repeated if dysentery recurs. Do not slaughter treated swine for food for at least 3 days following treatment.

GENTORAL®

Swine (neonatal)

In neonatal swine 1 to 3 days of age for control and treatment of colibacillosis caused by strains of E. coli sensitive to gentamicin.

For use in neonatal swine only.

Garacin® Pig Pump Oral Solution

For the treatment of infections of urinary tract (cystitis, nephritis), respiratory tract (pneumonitis pneumonia, upper respiratory tract infections), skin and soft tissue (wounds, lacerations, peritonitis), and as supportive therapy for secondary bacterial infections associated with panleucopenia.

If response is not noted after 7 days, the antibiotic sensitivity of the infecting organism should be retested. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Gentocin® Solution

GENTOCIN® Ophthalmic Solution is indicated for topical treatment of conjunctivitis caused by susceptible bacteria in dogs and cats

Gentocin® Ophthalmic Solution

For the treatment of acute and chronic canine otitis externa caused by bacteria sensitive to gentamicin.

If hypersensitivity to any of the components occurs treatment with this product should be discontinued and appropriate therapy instituted. Concomitant use with other drugs known to induce ototoxicity is not recommended. This preparation should not be used in conditions where corticosteroids are contraindicated. Do not administer parenteral corticosteroids during treatment with this drug. The antibiotic sensitivity of the pathogenic organism should be determined prior to use of this preparation. For use by or on the order of a licensed veterinarian.

VET BETA-GEN®

For the treatment of feline superficial infected lesions caused by bacteria sensitive to gentamicin.

If hypersensitivity to any of the components occurs treatment with this product should be discontinued and appropriate therapy instituted. Concomitant use with other drugs known to induce ototoxicity is not recommended. This preparation should not be used in conditions where corticosteroids are contraindicated. Do not administer parenteral corticosteroids during treatment with this drug. The antibiotic sensitivity of the pathogenic organism should be determined prior to use of this preparation. For use by or on the order of a licensed veterinarian.

VET BETA-GEN®

The drug is used for topical treatment of conjunctivitis caused by susceptible bacteria.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Vetro-Gen™ Veterinary Ophthalmic Ointment

Turkey (eggs)

The drug is recommended as an aid in the reduction or elimination of the following microorganisms from turkey-hatching eggs: Arizona hinshawii (paracolon), Salmonella st. paul, and Mycoplasma meleagris.

For use in the dipping treatment of turkey-hatching eggs only. Eggs which have been dipped in the drug shall not be used for food.

Gentasol

Turkeys (1 to 3 day old poults)

As an aid in the prevention of early mortality due to Arizona paracolon infections susceptible to gentamicin.

For 1 to 3 day old turkey poults. Administer subcutaneously in the neck. Injected poults must not be slaughtered for food for at least 9 weeks after treatment.

Genta-Ject®

Turkeys (1- to 3-day old poults)

As an aid in the prevention of early mortality due to Arizona paracolon infections susceptible to gentamicin.

For 1- to 3-day old turkey poults.

Garasol® Injection

Turkeys (1- to 3-day-old poults)

As an aid in the prevention of early mortality due to Arizona paracolon infections susceptible to gentamicin sulfate.

Injected poults must not be slaughtered for food for at least 9 weeks after treatment.

Garasol®

As an aid in the prevention of early mortality of 1 to 3-day-old turkeys associated with Arizona paracolon infections susceptible to gentamicin sulfate.

GentaMed™-P

Chickens (day-old)

For prevention of early mortality caused by Escherichia coli. Salmonella typhimurium, and Pseudomonas aeruginosa that are susceptible to gentamicin.

Do not slaughter treated animals for food for at least 5 weeks after treatment. Administer aseptically injecting the diluted product subcutaneously in the neck.

Genta-Ject®

Chickens (1 day old chicks)

For prevention of early mortality caused by Escherichia coli. Salmonella typhimurium, and Pseudomonas aeruginosa that are susceptible to gentamicin.

Do not slaughter treated animals for food for at least 5 weeks after treatment. Administer aseptically injecting the diluted product subcutaneously in the neck.

GentaPoult

For the prevention of early mortality in day-old chickens associated with Escherichia coli, Salmonella typhimurium, and Pseudomonas aeruginosa susceptible to gentamicin sulfate.

GentaMed™-P

Horses (mares)

The drug is indicated for use for control of bacterial infections of the uterus in horses (metritis) and as an aid in improving conception in mares with uterine infections caused by bacteria sensitive to gentamicin.

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption.

Gentamex™ 100

The drug is indicated for use for control of bacterial infections of the uterus in horses (metritis) and as an aid in improving conception in mares with uterine infections caused by bacteria sensitive to gentamicin.

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption

Gentamicin Sulfate Solution

The drug is indicated for the treatment of pink eye in cattle (infectious bovine keratoconjunctivitis) caused by Moraxella bovis.

Gentocin® Pink Eye Spray

GENTAMAX® 100 (Gentamicin Sulfate Solution) is recommended for the control of bacterial infections of the uterus (metritis) in horses and as an aid in improving conception in mares with uterine infections caused by bacteria sensitive to gentamicin. Bacteriologic studies should be conducted to identify the causative organism and to determine its sensitivity to gentamicin sulfate. Sensitivity discs of the drug are available for this purpose.

GENTAMAX® 100 (GENTAMICIN SULFATE SOLUTION) 100 mg/mL

INDICATIONS GENTOCIN DURAFILM Ophthalmic Solution is indicated for the treatment of external eye infections and inflammation in dogs. Clinical reports indicate it is useful for the management of some cases of pigmentary keratitis and pannus. Temporary remission of some of the pathological lesions of the aforementioned conditions have been noted following therapy with GENTOCIN DURAFILM Ophthalmic Solution.

Gentocin® Durafilm® (gentamicin sulfate and betamethasone acetate ophthalmic solution)

INDICATIONS Day-old chickens – GARASOL Injection is recommended for the prevention of early mortality associated with Escherichia coli, Salmonella typhimurium, and Pseudomonas aeruginosa susceptible to gentamicin sulfate. Turkeys – As an aid in the prevention of early mortality of 1- to 3-day-old turkeys associated with Arizona paracolon infections susceptible to gentamicin sulfate.

Garasol® (gentamicin injection)

INDICATIONS: Mometavet™ Otic Suspension is indicated for the treatment of otitis externa in dogs caused by susceptible strains of yeast (Malassezia pachydermatis) and bacteria (Pseudomonas spp. [including P . aeruginosa], coagulase-positive staphylococci, Enterococcus faecalis, Proteus mirabilis, and beta-hemolytic streptococci).

MOMETAVETTM (gentamicin sulfate, mometasone furoate anhydrous, and clotriamzole Otic Suspension)

INDICATIONS: MOMETAMAX Otic Suspension is indicated for the treatment of otitis externa in dogs caused by susceptible strains of yeast (Malassezia pachydermatis) and bacteria (Pseudomonas spp. [including P. aeruginosa], coagulase-positive staphylococci, Enterococcus faecalis, Proteus mirabilis, and beta-hemolytic streptococci).

MOMETAMAX® (GENTAMICIN SULFATE, MOMETASONE FUROATE MONOHYDRATE, AND CLOTRIMAZOLE, OTIC SUSPENSION)

INDICATIONS MotaZol™ Otic Suspension is indicated for the treatment of otitis externa in dogs caused by susceptible strains of yeast (Malassezia pachydermatis) and bacteria (Pseudomonas spp. [including P. aeruginosa], coagulasepositive staphylococci, Enterococcus faecalis, Proteus mirabilis, and beta-hemolytic streptococci).

VET one® MotaZol™ (GENTAMICIN SULFATE, MOMETASONE FUROATE MONOHYDRATE, AND CLOTRIMAZOLE, OTIC SUSPENSION)

For use in swine drinking water only. INDICATIONS: GEN-GARD Soluble Powder is recommended for the control and treatment of colibacillosis in weanling swine caused by strains of E. coli sensitive to gentamicin, and for the control and treatment of swine dysentery associated with Brachyspira hyodysenteriae.

FDA application 200-185

INDICATIONS: GentaMed™ Soluble Powder is recommended for the control and treatment of colibacillosis in weanling swine caused by strains of E. coli sensitive to gentamicin and for the control and treatment of swine dysentery associated with Brachyspira hyodysenteriae.

FDA application 200-494

INDICATIONS: Mometamax Single is indicated for the treatment of otitis externa associated with susceptible strains of yeast (Malassezia pachydermatis) and bacteria (Staphylococcus pseudintermedius and Pseudomonas aeruginosa) in dogs.

Mometamax Single™ (gentamicin, posaconazole, andmometasone furoate otic suspension)

INDICATIONS: OTOMAX ointment is indicated for the treatment of canine acute and chronic otitis externa associated with yeast (Malassezia pachydermatis, formerly Pityrosporum canis) and/or bacteria susceptible to gentamicin.

Otomax® (GENTAMICIN SULFATE, BETAMETHASONE VALERATE, AND CLOTRIMAZOLE, OINTMENT)

EASOTIC Otic Suspension is indicated for the treatment of otitis externa in dogs associated with susceptible strains of yeast (Malassezia pachydermatis) and bacteria (Staphylococcus pseudintermedius).

EASOTIC® (hydrocortisone aceponate, miconazole nitrate, gentamicin sulfate) Otic Suspension for Dogs

For Otic Use in Dogs Only. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Keep this and all drugs out of the reach of children.

Otomax® (GENTAMICIN SULFATE, BETAMETHASONE VALERATE, AND CLOTRIMAZOLE, OINTMENT)

For topical use in dogs only. For the treatment of infected superficial lesions in dogs caused by bacteria susceptible to gentamicin. Read accompanying directions carefully.

GENTACALM®​ Topical Spray

Gentamicin Piglet Injection is recommended for the treatment of porcine colibacillosis caused by strains of E. coli sensitive to gentamicin.

Gentamicin Piglet Injection (GENTAMICIN SULFATE, USP) Piglet Injection - 5 mg/mL

For the treatment of infected superficial lesions in dogs caused by bacteria susceptible to gentamicin. Keep Out of Reach of Children.

GenOne™ Spray

For the treatment of infected superficial lesions in dogs caused by bacteria susceptible to gentamicin.

GentaVed Topical Spray Gentamicin Sulfate With Betamethasone Valerate TOPICAL SPRAY

Gentamicin Sulfate, USP With Betamethasone Valerate, USP Veterinary For Topical Use in Dogs Only

GENTACALM®​ Topical Spray

For the topical treatment of conjunctivitis caused by susceptible bacteria in dogs and cats

Federal law restricts this drug to use by or on the order of a licensed veterinarian

Gentamicin Sulfate Ophthalmic Solution

For treatment of external eye infections and inflammation in dogs.

Gentocin® Durafilm®

PHARMACOLOGY: Gentamicin: Gentamicin sulfate is an aminoglycoside antibiotic active against a wide variety of gram-negative and gram-positive bacteria. In vitro tests have determined that gentamicin is bactericidal and acts by inhibiting normal protein synthesis in susceptible microorganisms. In clinical trials, gentamicin was shown to have a range of activity against the following organisms commonly isolated from infected canine ears: Pseudomonas spp. (including P. aeruginosa), coagulase-positive staphylococci, Enterococcus faecalis, Proteus mirabilis and beta-hemolytic streptococci. Mometasone: Mometasone furoate anhydrous is a synthetic adrenocorticoid characterized by a novel (2') furoate 17-ester having chlorine at the 9 and 21 positions, which have shown to possess high topical potency. Systemic absorption of mometasone furoate ointment was found to be minimal (2%) over 1 week when applied topically to dogs with intact skin. In a 6-month dermal toxicity study using 0.1% mometasone ointment on healthy intact skin in dogs, systemic effects typical of corticosteroid therapy were noted. The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the integrity of the epidermal barrier. Topical corticosteroids can be absorbed from normal, intact skin. Inflammation can increase percutaneous absorption. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Clotrimazole: Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of dermatophytes and yeast. The primary action of clotrimazole is against dividing and growing organisms. I n vitro, clotrimazole exhibits fungistatic and fungicidal activity against isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida spp., and Malassezia pachydermatis. Resistance to clotrimazole is very rare among the fungi that cause superficial mycoses. In an induced otitis externa study using dogs infected with M alassezia pachydermatis, 1% clotrimazole in the vehicle formulation was effective both microbiologically and clinically in terms of reduction of exudate, odor and swelling. In studies of the mechanism of action, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorus compounds into the ambient medium with concomitant breakdown of cellular nucleic acids and accelerated potassium efflux. These events began rapidly and extensively after addition of the drug. Clotrimazole is very poorly absorbed following dermal application. G e n t am i cin- M o m e t a s o n e - Clo t ri m a z o l e : By virtue of its three active ingredients, gentamicin, mometasone, and clotrimazole otic suspension has antibacterial, anti-inflammatory, and antifungal activity. In clinical field trials, gentamicin, mometasone, and clotrimazole otic suspension was effective in the treatment of otitis externa associated with bacteria and Malassezia pachydermatis. Gentamicin, mometasone, and clotrimazole otic suspension reduced discomfort, redness, swelling, exudate, and odor.

MOMETAVETTM (gentamicin sulfate, mometasone furoate anhydrous, and clotriamzole Otic Suspension)

CLINICAL PHARMACOLOGY GENTOCIN DURAFILM Ophthalmic Solution incorporates polyoxyl 40 stearate and polyethoxy 35 castor oil which provide a colloidal dispersion of active ingredients. This aqueous colloidal solution offers specific advantages in treating eye conditions. DURAFILM covers the conjunctiva with a thin, clear, quickly spreading film which carries therapeutic components to accessible structures and maintains prolonged contact. GENTOCIN DURAFILM Ophthalmic Solution provides the antibacterial properties of gentamicin sulfate plus the anti-inflammatory action of betamethasone acetate. Gentamicin sulfate, a wide-spectrum antibiotic, is a highly effective topical treatment in primary and secondary bacterial infections of the eye and surrounding tissues. Gentamicin is bactericidal in vitro against a wide variety of gram-positive and gram-negative bacteria. Concentrations of gentamicin sulfate required to inhibit growth of gram positive and gram-negative clinical and laboratory strains of bacteria tested were less than those of neomycin in most instances.1. Gentamicin is active against most gram-negative bacteria including Pseudomonas aeruginosa, indole positive and negative Proteus species, Escherichia coli, Kiebsiella pneumoniae, Aerobacter aerogenes, and Neisseria. Gentamicin is also active against strains of gram-positive bacteria including Staphylococcus species and Group A Beta-Hemolytic Streptococci. Betamethasone produces hormonal and metabolic effects common to all adrenocortical steroids, and in low dosage affords anti-inflammatory, anti-allergic, and anti-rheumatic effects. Studies in man show the glucocorticoid activity of betamethasone to be 10 to 15 times greater than prednisone. Betamethasone helps control excessive tissue reaction to infections, allergens, and trauma. The corticoids control the inflammatory and exudate phases of eye conditions, particularly those affecting the anterior chamber and external structure of the eye. However, they do not curtail the growth of the causative organisms. Betamethasone therapy may reduce the damaging sequelae in certain eye diseases and injuries as well as scarring and vascularization, and appears to alter the usual tissue response to injury. In initial acute phases of inflammation, local application of betamethasone provides prompt, symptomatic relief, accomplishing temporary control of the exudative phase, whether of bacterial, allergic, or traumatic origin. Betamethasone also inhibits fibroblast formation during tissue repair.

Gentocin® Durafilm® (gentamicin sulfate and betamethasone acetate ophthalmic solution)

CHEMISTRY Gentamicin is a mixture of aminoglycoside antibiotics derived from the fermentation of Micromonospora purpurea. Gentamicin sulfate is a mixture of sulfate salts of the antibiotics produced in this fermentation. The salts are weakly acidic and freely soluble in water. Gentamicin sulfate contains not less than 500 micrograms of gentamicin base per milligram. Betamethasone valerate is a synthetic glucocorticoid. PHARMACOLOGY Gentamicin, a broad-spectrum antibiotic, is a highly effective topical treatment for bacterial infections of the skin. In vitro, gentamicin is bactericidal against a wide variety of gram-positive and gram-negative bacteria isolated from domestic animals.1,2 Specifically, gentamicin is active against the following organisms isolated from canine skin: Alcaligenes sp., Citrobacter sp., Klebsiella sp., Pseudomonas aeruginosa, indole-positive and negative Proteus sp., Escherichia coli, Enterobacter sp., Staphylococcus sp., and Streptococcus sp. Betamethasone valerate emerged from intensive research as the most promising of some 50 newly synthesized corticosteroids in the experimental model described by McKenzie3, et al. This human bioassay technique has been found reliable for evaluating the vasoconstrictor properties of new topical corticosteroids and is useful in predicting clinical efficacy. Betamethasone valerate in veterinary medicine has been shown to provide anti-inflammatory and antipruritic activity in the topical management of corticosteroid-responsive infected superficial lesions in dogs.

GentaVed Topical Spray Gentamicin Sulfate With Betamethasone Valerate TOPICAL SPRAY

Gentamicin, a broad-spectrum antibiotic, is a highly effective topical treatment for bacterial infections of the skin. In vitro, gentamicin is bactericidal against a wide variety of gram-positive and gram-negative bacteria isolated from domestic animals.1,2 Specifically, gentamicin is active against the following organisms isolated from canine skin: Alcaligenes sp., Citrobacter sp., Klebsiella sp., Pseudomonas aeruginosa, indole-positive and -negative Proteus sp., Escherichia coli, Enterobacter sp., Staphylococcus sp., and Streptococcus sp. Betamethasone valerate emerged from intensive research as the most promising of some 50 newly synthesized corticosteroids in the experimental model described by McKenzie,3 et al. This human bioassay technique has been found reliable for evaluating the vasoconstrictor properties of new topical corticosteroids and is useful in predicting clinical efficacy. Betamethasone valerate in veterinary medicine has been shown to provide anti-inflammatory and antipruritic activity in the topical management of corticosteroid-responsive infected superficial lesions in dogs.

GENTACALM®​ Topical Spray

CLINICAL PHARMACOLOGY: Mometamax Single is a combination of three active ingredients: gentamicin (antibacterial), posaconazole (antifungal), and mometasone furoate (steroidal anti-inflammatory). Gentamicin is an aminoglycoside bactericidal antibiotic which acts by binding to the 30S ribosomal subunit leading to inhibition of bacterial protein synthesis. Posaconazole is a triazole antifungal which selectively inhibits an enzyme involved in the biosynthesis of ergosterol. Mometasone furoate is a corticosteroid that binds to glucocorticoid receptors resulting in anti-inflammatory activity.

Mometamax Single™ (gentamicin, posaconazole, andmometasone furoate otic suspension)

Hydrocortisone aceponate is a glucocorticoid with anti-inflammatory effects. Miconazole nitrate is an imidazole antifungal. Gentamicin sulfate is an aminoglycoside antibiotic. In the target animal safety study, hydrocortisone aceponate, miconazole and gentamicin were shown to be systemically absorbed from the ears of healthy dogs (see ANIMAL SAFETY ); increased systemic absorption may be observed in inflamed ears.

EASOTIC® (hydrocortisone aceponate, miconazole nitrate, gentamicin sulfate) Otic Suspension for Dogs

CONTRAINDICATIONS: There are no known contraindications to this drug when used as directed. To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae.

FDA application 200-494

CONTRAINDICATIONS Corticosteroids are contraindicated in initial treatment of corneal ulcers. GENTOCIN DURAFILM Ophthalmic Solution is contraindicated in ocular conditions where there is deep ulceration without vascularization and in conditions of viral origin before healing has commenced.

Gentocin® Durafilm® (gentamicin sulfate and betamethasone acetate ophthalmic solution)

CONTRAINDICATIONS: If hypersensitivity to any of the components occurs, treatment should be discontinued and appropriate therapy instituted. Concomitant use of drugs known to induce ototoxicity should be avoided. Do not use in dogs with known perforation of eardrums.

MOMETAVETTM (gentamicin sulfate, mometasone furoate anhydrous, and clotriamzole Otic Suspension)

CONTRAINDICATIONS: Do not use in dogs with known tympanic membrane perforation (see Animal Safety Warnings and Precautions ). Do not use in dogs with known or suspected hypersensitivity to gentamicin, posaconazole, or mometasone furoate.

Mometamax Single™ (gentamicin, posaconazole, andmometasone furoate otic suspension)

Do not use in dogs with known tympanic membrane perforation. EASOTIC Otic Suspension is contraindicated in dogs with known or suspected hypersensitivity to corticosteroids, imidazole antifungals, or aminoglycoside antibiotics.

EASOTIC® (hydrocortisone aceponate, miconazole nitrate, gentamicin sulfate) Otic Suspension for Dogs

If hypersensitivity to any of the components occurs, discontinue treatment and institute appropriate therapy.

GenOne™ Spray

CONTRAINDICATIONS: There are no known contraindications to this drug when used as directed.

FDA application 200-185

There are no known contraindications to this drug when used as directed.

GENTAMAX® 100 (GENTAMICIN SULFATE SOLUTION) 100 mg/mL

WARNINGS: The use of these components has been associated with deafness or partial hearing loss in a small number of sensitive dogs (e.g, geriatric). The hearing deficit is usually temporary. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue use of Mometavet™ Otic Suspension immediately and flush the ear canal thoroughly with a non-toxic solution. Corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Other congenital anomalies including deformed forelegs, phocomelia, and anasarca have been reported in offspring of dogs that received corticosteroids during pregnancy. Field and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. P RE C AUTIONS: Before instilling any medication into the ear, examine the external ear canal thoroughly to be certain the tympanic membrane is not ruptured in order to avoid the possibility of transmitting infection to the middle ear as well as damaging the cochlea or vestibular apparatus from prolonged contact. Administration of recommended doses of Mometavet™ Otic Suspension beyond 7 days may result in delayed wound healing. If overgrowth of non-susceptible bacteria or fungi occurs, treatment should be discontinued and appropriate therapy instituted. Avoid ingestion. Adverse systemic reactions have been observed following the oral ingestion of some topical corticosteroid preparations. Patients should be closely observed for the usual signs of adrenocorticoid overdosage which include sodium retention, potassium loss, fluid retention, weight gain, polydipsia, and/or polyuria. Prolonged use or overdosage may produce adverse immunosuppressive effects. Use of corticosteroids, depending on dose, duration, and specific steroid, may result in endogenous steroid production inhibition following drug withdrawal. In patients presently receiving or recently withdrawn from corticosteroid treatments, therapy with a rapidly acting corticosteroid should be considered in especially stressful situations.

MOMETAVETTM (gentamicin sulfate, mometasone furoate anhydrous, and clotriamzole Otic Suspension)

Human Warnings: Not for use in humans. Keep this and all drugs out of reach of children. In case of accidental skin contact, wash area thoroughly with soap and water. Avoid contact with eyes. Humans with known or suspected hypersensitivity to hydrocortisone, aminoglycoside antibiotics, or azole antifungals should not handle this product. In case of accidental ingestion by humans, contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans. Animal Warnings: As a class, aminoglycoside antibiotics are associated with ototoxicity, vestibular dysfunction and renal toxicity. The use of EASOTIC Otic Suspension in a dog with a damaged tympanic membrane can result in damage to the structures of the ear associated with hearing and balance or in transmission of the infection to the middle or inner ear. Immediately discontinue use of EASOTIC Otic Suspension if hearing loss or signs of vestibular dysfunction are observed during treatment (see ADVERSE REACTIONS).

EASOTIC® (hydrocortisone aceponate, miconazole nitrate, gentamicin sulfate) Otic Suspension for Dogs

WARNINGS: The use of these components has been associated with deafness or partial hearing loss in a small number of sensitive dogs (e.g., geriatric). The hearing deficit is usually temporary. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue use of MOMETAMAX Otic Suspension immediately and flush the ear canal thoroughly with a non-ototoxic solution. Corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Other congenital anomalies including deformed forelegs, phocomelia, and anasarca have been reported in offspring of dogs that received corticosteroids during pregnancy. Field and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis.

MOMETAMAX® (GENTAMICIN SULFATE, MOMETASONE FUROATE MONOHYDRATE, AND CLOTRIMAZOLE, OTIC SUSPENSION)

WARNINGS: The use of OTOMAX ointment has been associated with deafness or partial hearing loss in a small number of sensitive dogs (e.g., geriatric). The hearing deficit is usually temporary. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue use of OTOMAX ointment immediately and flush the ear canal thoroughly with a nonototoxic solution. Corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Other congenital anomalies including deformed forelegs, phocomelia, and anasarca have been reported in offspring of dogs which received corticosteroids during pregnancy. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis.

Otomax® (GENTAMICIN SULFATE, BETAMETHASONE VALERATE, AND CLOTRIMAZOLE, OINTMENT)

WARNINGS Not for human use. Keep this and all drugs out of the reach of children. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Additionally, corticosteroids administered to dogs, rabbits, and rodents during pregnancy have produced cleft palate. Other congenital anomalies including deformed forelegs, phocomelia, and anasarca have been reported in offspring of dogs which received corticosteroids during pregnancy.

Gentocin® Durafilm® (gentamicin sulfate and betamethasone acetate ophthalmic solution)

Clinical and experimental data have demonstrated that corticosteriods administrated orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Additionally, corticosteroids administered to dogs, rabbits and rodents during pregnancy have produced cleft palate. Other congenital abnormalities including deformed forelegs, phocomelia, and anasarca have been reported in offspring of dogs which received corticosteroids during pregnancy.

GentaVed Topical Spray Gentamicin Sulfate With Betamethasone Valerate TOPICAL SPRAY

For use in piglets up to 3 days of age only. Piglets injected with Gentamicin Piglet Injection must not be slaughtered for food for at least forty (40) days following treatment. Use of more than the recommended dose will result in gentamicin tissue residues beyond forty (40) days. Restricted Drug (California)--use only as directed. Read accompanying directions carefully.

Gentamicin Piglet Injection (GENTAMICIN SULFATE, USP) Piglet Injection - 5 mg/mL

Residue Warnings For use in day-old chickens and 1- to 3-day-old turkeys only. Chickens injected with GARASOL Injection must not be slaughtered for food for at least 5 weeks following treatment. Turkeys injected with GARASOL Injection must not be slaughtered for food for at least 9 weeks following treatment.

Garasol® (gentamicin injection)

DESCRIPTION: Each gram of GEN-GARD Soluble Powder contains gentamicin sulfate equivalent to 333.33 mg gentamicin base. RESIDUE WARNING: Swine treated with the recommended dose of GEN-GARD Soluble Powder must not be slaughtered for food for at least ten (10) days following the last treatment.

FDA application 200-185

Each gram contains: gentamicin sulfate equivalent to 333.33 mg gentamicin base. RESIDUE WARNIN G: Swine treated with the recommended dose of GEN-GARD Soluble Powder must not be slaughtered for food for at least ten (10) days following the last treatment.

FDA application 200-185

RESIDUE WARNING: For use in swine drinking water only. Swine treated with the recommended dose of GentaMed™ Soluble Powder must not be slaughtered for food for at least ten (10) days following the last treatment.

FDA application 200-494

CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Keep this and all drugs out of the reach of children.

MOMETAMAX® (GENTAMICIN SULFATE, MOMETASONE FUROATE MONOHYDRATE, AND CLOTRIMAZOLE, OTIC SUSPENSION)

Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Mometamax Single™ (gentamicin, posaconazole, andmometasone furoate otic suspension)

NOT FOR USE IN HUMANS KEEP OUT OF REACH OF CHILDREN

FDA application 200-185

A D VE R S E R E ACTIONS: Ge n tam i ci n : While aminoglycosides are absorbed poorly from skin, intoxication may occur when aminoglycosides are applied topically for prolonged periods of time to large wounds, burns, or any denuded skin, particularly if there is renal insufficiency. All aminoglycosides have the potential to produce reversible and irreversible vestibular, cochlear, and renal toxicity. M o m e t a s o n e : ALP (SAP) and ALT (SGPT) enzyme elevations, weight loss, anorexia, polydipsia, polyuria, neutrophilia, and lymphopenia have occurred following the use of parenteral, high-dose, and/or prolonged or systemic synthetic corticosteroids in dogs. Cushing's syndrome in dogs has been reported in association with prolonged or repeated steroid therapy. Clo t rima z o l e : The following have been reported occasionally in humans in connection with the use of clotrimazole: erythema, stinging, blistering, peeling, edema, pruritus, urticaria, and general irritation of the skin not present before therapy. Mometavet™ Otic Suspension: In field studies following once-daily treatment with gentamicin, mometasone, and clotrimazole otic suspension, ataxia, proprioceptive deficits, and increased water consumption were observed in less than 1% of 164 dogs. In a field study following twice-daily treatment with gentamicin, mometasone, and clotrimazole otic suspension, inflammation of the pinna and diarrhea were observed in less than 1% of 141 dogs. To report suspected adverse drug events, for technical assistance, or to obtain a Safety Data Sheet (SDS), contact Dechra at (866) 933-2472. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/reportanimalae

MOMETAVETTM (gentamicin sulfate, mometasone furoate anhydrous, and clotriamzole Otic Suspension)

ADVERSE REACTIONS SAP and SGPT (ALT) enzyme elevations, polydipsia, and polyuria have occurred following parenteral or systemic use of synthetic corticosteroids in dogs. Vomiting and diarrhea (occasionally bloody) have been observed in dogs. Cushing's syndrome in dogs has been reported in association with prolonged or repeated steroid therapy. A transient stinging sensation, usually expressed as some form of resentment by the animal, following topical application of the drug, has been noted in a small number of cases. Usually this does not require discontinuance of therapy. To report an adverse reaction, product-related problem, or human exposure, please call Merck Animal Health Technical Services at 1-800-224-5318. To obtain a copy of the Material Safety Data Sheet (MSDS), call 1-800-770-8878. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae

Gentocin® Durafilm® (gentamicin sulfate and betamethasone acetate ophthalmic solution)

In a field study conducted in the United States (see EFFECTIVENESS), there were no adverse reactions reported in 145 dogs administered EASOTIC (hydrocortisone aceponate, miconazole nitrate, gentamicin sulfate) Otic Suspension for Dogs. In foreign market experience, reports of hearing loss and application site erythema have been received. In most reported cases, the hearing loss and erythema were transient and resolved with discontinuation of EASOTIC Otic Suspension. CONTACT INFORMATION To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Virbac AH, Inc. at 1-800-338-3659 or us.virbac.com. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae.

EASOTIC® (hydrocortisone aceponate, miconazole nitrate, gentamicin sulfate) Otic Suspension for Dogs

SIDE EFFECTS: There have been no reported side effects following the recommended use of GEN-GARD Soluble Powder in swine. To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Huvepharma, Inc. at 1-877-994-4883 or www.huvepharma.us. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae.

FDA application 200-185

ADVERSE REACTIONS: The following adverse reactions were reported during the course of a U.S. field study for treatment of otitis externa in dogs treated with Mometamax Single. Frequency of Adverse Reactions by Treatment Adverse Reaction Mometamax Single (N=245) Control (N=127) Vomiting 21 (8.6%) 4 (3.1%) Decreased appetite 9 (3.7%) 2 (1.6%) Pruritus 8 (3.3%) 2 (1.6%) Ear pruritus 7 (2.9%) 1 (0.8%) Disorientation 3 (1.2%) 0 (0.0%)

Mometamax Single™ (gentamicin, posaconazole, andmometasone furoate otic suspension)

Side effects such as SAP and SGPT enzyme elevations, weight loss, anorexia, polydipsia, and polyuria have occurred following parenteral or systemic use of synthetic corticosteroids in dogs. Vomiting and diarrhea (occasionally bloody) have been observed in dogs. Cushing’s syndrome in dogs has been reported in association with prolonged or repeated steroid therapy.

GenOne™ Spray

To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact First Priority, Inc. at (800) 650-4899 or www.prioritycare.com. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae

GenOne™ Spray

To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Dechra at (866) 933-2472. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/reportanimalae

GENTACALM®​ Topical Spray

There have been no reports of drug hypersensitivity or adverse side effects following the recommended intrauterine infusion of gentamicin sulfate solution combined with sterile physiological saline in mares.

GENTAMICIN SULFATE SOLUTION 100 mg/mL

SIDE EFFECTS: There have been no reported side effects following the recommended use of GentaMed™ Soluble Powder in swine.

FDA application 200-494

From 7.5- or 15-g tube; 10-, 15-, or 25-g bottles install 4 drops of ointment twice daily into the ear canal of dogs weighing less than 30 pounds, instill 8 drops twice daily for dogs weighing 30 pounds or more. From 215-g bottle, instill 2 drops of ointment twice daily into the ear canal of dogs weighing less than 30 pounds, instill 4 drops twice daily for dogs weighing 30 pounds or more. Therapy should continue for 7 consecutive days. The external ear should be cleaned and dried before treatment. Remove foreign material, debris, crusted exudates, etc. with suitable solutions. Excessive hair should be clipped from the treatment area. If hypersensitivity occurs, treatment should be discontinued and alternate therapy instituted.

Topical

Corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Other congenital anomalies including deformed forelegs, phocomelia, and anasarca have been reported in offspring of dogs which received corticosteroids during pregnancy. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition, followed by dystocia, fetal death, retained placenta and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Tri-Otic® Ointment

The drug is administered by instillation of 3 to 8 drops of solution into the ear canal twice daily for 7 to 14 days. Duration of treatment will depend upon the severity of the condition and the response obtained. The duration of treatment and/or frequency of the dosage may be reduced but care should be taken not to discontinue therapy prematurely. The external ear and ear canal should be properly cleaned and dried before treatment. Remove foreign material, debris, crusted exudates, etc., with suitable nonirritating solutions. Excessive hair should be clipped from the treatment area of the external ear.

Topical

If hypersensitivity to any of the components occurs treatment with this product should be discontinued and appropriate therapy instituted. Concomitant use with other drugs known to induce ototoxicity is not recommended. This preparation should not be used in conditions where corticosteroids are contraindicated. Do not administer parenteral corticosteroids during treatment with this drug. The antibiotic sensitivity of the pathogenic organism should be determined prior to use of this preparation. For use by or on the order of a licensed veterinarian.

VET BETA-GEN®

For dogs weighing less than 30 lbs, instill 4 drops from the 7.5 g tubes and bottles, 15 g tubes and bottles, and 30 g bottles (2 drops from the 215 g bottle) once daily in the ear canal. For dogs weighing 30 lbs or more, instill 8 drops from the 7.5 g tubes and bottles, 15 g tubes and bottles, and 30 g bottles (4 drops from the 215 g bottle) once daily in the ear canal. Therapy should continue for 7 consecutive days.

Otic

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Mometavet®

For the treatment of acute and chronic canine otitis externa the drug is administered by instillation of 3 to 8 drops into the ear canal twice daily for 7 days. The external ear and ear canal should properly cleaned and dried before treatment. Remove foreign material, debris, crusted exudates, etc., with suitable nonirritating solutions. Excessive hair should be clipped from the treatment area of the external ear.

Topical

If hypersensitivity to any of the components occurs, treatment should be discontinued and appropriate therapy instituted. Concomitant use of drugs known to induce ototoxicity should be avoided. Observe patients for signs of adrenocorticoid overdosage. The antibiotic susceptibility of the pathogenic organism should be determined prior to use of this preparation. Administration of recommended doses beyond 7 days may result in delayed wound healing. Animals treated longer than 7 days should be monitored closely. For use by or on the order of a licensed veterinarian.

Topagen® Ointment

For the treatment of infected superficial lesions, the lesion and adjacent area should be properly cleaned before treatment. Excessive hair should be removed. Hold bottle upright 3 to 6 inches from the lesion and depress the sprayer head twice. One actuation of the sprayer delivers 0.7 milliliter of the spray. The drug should be administered with two spray actuations 2 to 4 times daily for 7 days.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Gentocin® Topical Spray

Install ointment twice daily into the ear canal. Therapy should continue for 7 consecutive days. From 10-g bottles: 4 drops for dogs weighing less than 30 pounds (lb) or 8 drops for dogs weighing 30 lb or more. From 20-, 40-, or 215-g bottles: 2 drops for dogs weighing less than 30 lb or 4 drops for dogs weighing 30 lb or more.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

GBC Ointment™

For the treatment of canine infected superficial lesions, the lesion and adjacent area should be properly cleaned before treatment. Excessive hair should be removed. A sufficient amount of the drug should be applied to cover the treatment area. The drug should be administered twice daily for 7 to 14 days.

Topical

If hypersensitivity to any of the components occurs, treatment should be discontinued and appropriate therapy instituted. Concomitant use of drugs known to induce ototoxicity should be avoided. Observe patients for signs of adrenocorticoid overdosage. The antibiotic susceptibility of the pathogenic organism should be determined prior to use of this preparation. Administration of recommended doses beyond 7 days may result in delayed wound healing. Animals treated longer than 7 days should be monitored closely. For use by or on the order of a licensed veterinarian.

Topagen® Ointment

For dogs weighing less than 30 lbs, instill 4 drops from the 7.5g, 15g, or 30g bottle into the ear canal (2 drops from the 215g bottle) or, for dogs weighing 30 lbs or more, instill 8 drops from the 7.5g, 15g or 30g bottle into the ear canal (4 drops from the 215g bottle), once daily for 7 days.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Mometamax™ Otic Suspension

The lesion and adjacent area should be properly cleaned before treatment. Excessive hair should be removed. A sufficient amount of the drug should be applied to cover the treatment area. The drug should be administered twice daily for 7 to 14 days.

Topical

If hypersensitivity to any of the components occurs treatment with this product should be discontinued and appropriate therapy instituted. Concomitant use with other drugs known to induce ototoxicity is not recommended. This preparation should not be used in conditions where corticosteroids are contraindicated. Do not administer parenteral corticosteroids during treatment with this drug. The antibiotic sensitivity of the pathogenic organism should be determined prior to use of this preparation. For use by or on the order of a licensed veterinarian.

VET BETA-GEN®

Two milligrams of gentamicin per pound of body weight, twice daily on the first day, once daily thereafter, using a 50 milligram-per-milliliter solution. Administer intramuscularly or subcutaneously.

Subcutaneous, Intramuscular

If response is not noted after 7 days, the antibiotic sensitivity of the infecting organism should be retested. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Gentocin® Solution

Verify that the tympanic membrane is intact. Carefully insert the canula into the affected external ear canal(s) and apply 1 mL (a single pump) once per day for 5 days. Wash hands after usage.

Otic

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For Otic Use in Dogs Only. Do not use in dogs with known tympanic membrane perforation.

Easotic®

From 7.5 or 15 gram tubes, install 4 drops of ointment twice daily into the ear canal of dogs weighing less than 30 pounds, instill 8 drops twice daily for dogs weighing 30 pounds or more.

Topical

Install ointment twice daily into the ear canal. Therapy should continue for 7 consecutive days. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Vetro-Max®

Hold bottle upright 3 to 6 inches from the lesion and depress the sprayer head twice. The drug should be administered with two spray actuations 2 to 4 times daily for 7 days.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian

Gentamicin Sulfate Topical Spray

Mometamax Single™ should be administered by veterinary personnel. The dose volume is 0.8 mL per affected ear. Verify the tympanic membrane is intact prior to administration.

Otic

Mometamax Single™

2 milligrams of gentamicin per pound of body weight, twice daily on the first day, then once daily. Administer intramuscularly or subcutaneously.

Intrasynovial, Intramuscular

If no improvement is seen after 3 days treatment should be discontinued and the diagnosis reevaluated. Treatment not to exceed 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Gentamicin Sulfate Inj. Sol.

Hold bottle upright 3 to 6 inches from the lesion and depress the sprayer head twice. Administer 2 to 4 times daily for 7 days.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

GB Topical Spray

Apply a sufficient amount of the drug to cover the treatment area twice daily for 7 to 14 days.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Gentocin® Otic Solution

Instill three to eight drops of solution into the ear canal twice daily for 7 to 14 days.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Gentocin® Otic Solution

Administer two depressions of the sprayer head 2 to 4 times daily for 7 days.

Topical

Gentamicin Topical Spray

Apply approximately a 1/2 inch strip to the affected eye 2 to 4 times a day.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Vetro-Gen™ Veterinary Ophthalmic Ointment

1 or 2 drops instilled into the conjuctival sac 2 to 4 times a day

Ophthalmic

Gentocin® Ophthalmic Solution

Swine (neonatal, 1 to 3 days of age)

Administer 1 mL of pig pump oral solution (5 mg of gentamicin) orally per pig one time.

Oral

Gentamicin Sulfate Pig Pump Oral Solution

50 mg gentamicin per gallon (1 level scoop/120 gallons) for three consecutive days to ensure a gentamicin dosage of approximately 1.0 mg/lb/day. (Note: the jar contains a scoop that provides approximately 18 g of product when level full.) For proportioner use, add 1 level scoop to 1 gallons stock solution and dispense at the rate of 1 oz/gal drinking water (50 mg/gal).

Oral

For use in swine drinking water only. Do not store or offer medicated drinking water in rusty containers since the drug is quickly destroyed in such containers. Medicated drinking water should be prepared daily and be the sole source of drinking water. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

GentaMed™

Administer gentamicin sulfate equivalent to 50 milligrams of gentamicin per gallon of drinking water to provide 1.0 milligram per pound of body weight per day for 3 consecutive days. Treatment may be repeated if dysentery recurs.

Oral

For use in swine drinking water only. Do not store or offer medicated drinking water in rusty containers since the drug is quickly destroyed in such containers. Medicated drinking water should be prepared daily and be the sole source of drinking water for 3 consecutive days. Do not slaughter treated swine for food for at least 10 days following treatment. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

GEN-GARD®

Gentamicin sulfate equivalent to 50 milligrams of gentamicin per gallon of drinking water for 3 consecutive days, to provide 1 milligram per pound of body weight per day.

Oral

For use in swine drinking water only. Do not store or offer medicated drinking water in rusty containers since the drug is quickly destroyed in such containers. Medicated drinking water should be prepared daily and be the sole source of drinking water.

Garacin® Soluble Powder

1 milliliter per 1 gallon of drinking water for 3 consecutive days, to provide 1.0 milligrams per pound per day.

Oral

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. For use in swine drinking water only. Do not store or offer medicated drinking water in rusty containers since the drug is quickly destroyed in such containers. Medicated drinking water should be prepared daily and be the sole source of drinking water for 3 consecutive days. Treatment may be repeated if dysentery recurs. Do not slaughter treated swine for food for at least 3 days following treatment.

GENTORAL®

5 milligrams of gentamicin as a single intramuscular dose using 5 milligram-per-milliliter solution.

Intramuscular

For single intramuscular dose in pigs up to 3 days of age only. Do not slaughter treated animals for food for at least 40 days following treatment

Gentamicin Piglet Injection

Swine (weanling)

25 mg gentamicin per gallon (1 level scoop/240 gallons) of drinking water, for three consecutive days to provide 0.5 mg/lb/day. (Note: the jar contains a scoop that provides approximately 18 g of product when level full.) For proportioner use, add 1 level scoop to 2 gallons stock solution and dispense at the rate of 1 oz/gal drinking water (25 mg/gal).

Oral

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

GentaMed™

Swine (weanling)

Administer gentamicin sulfate equivalent to 25 milligrams of gentamicin per gallon of drinking water to provide 0.5 milligram per pound of body weight per day for 3 consecutive days.

Oral

For use in swine drinking water only. Do not store or offer medicated drinking water in rusty containers since the drug is quickly destroyed in such containers. Medicated drinking water should be prepared daily and be the sole source of drinking water for 3 consecutive days. Do not slaughter treated swine for food for at least 10 days following treatment. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

GEN-GARD®

Swine (weanling)

Gentamicin sulfate equivalent to 25 milligrams of gentamicin per gallon of drinking water for 3 consecutive days, to provide 0.5 milligram per pound of body weight per day.

Oral

Garacin® Soluble Powder

Swine (weanling)

1 milliliter per 2 gallons of drinking water for 3 consecutive days, to provide 0.5 milligrams per pound per day.

Oral

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. For use in swine drinking water only. Do not store or offer medicated drinking water in rusty containers since the drug is quickly destroyed in such containers. Medicated drinking water should be prepared daily and be the sole source of drinking water for 3 consecutive days. Treatment may be repeated if dysentery recurs. Do not slaughter treated swine for food for at least 3 days following treatment.

GENTORAL®

Swine (neonatal)

Administer 1.15 milliliters of pig pump oral solution (5 mg of gentamicin) orally per pig one time.

Oral

For use in neonatal swine only.

Garacin® Pig Pump Oral Solution

The drug is administered by instillation of 3 to 8 drops of solution into the ear canal twice daily for 7 to 14 days. Duration of treatment will depend upon the severity of the condition and the response obtained. The duration of treatment and/or frequency of the dosage may be reduced but care should be taken not to discontinue therapy prematurely. The external ear and ear canal should be properly cleaned and dried before treatment. Remove foreign material, debris, crusted exudates, etc., with suitable nonirritating solutions. Excessive hair should be clipped from the treatment area of the external ear.

Topical

If hypersensitivity to any of the components occurs treatment with this product should be discontinued and appropriate therapy instituted. Concomitant use with other drugs known to induce ototoxicity is not recommended. This preparation should not be used in conditions where corticosteroids are contraindicated. Do not administer parenteral corticosteroids during treatment with this drug. The antibiotic sensitivity of the pathogenic organism should be determined prior to use of this preparation. For use by or on the order of a licensed veterinarian.

VET BETA-GEN®

The lesion and adjacent area should be properly cleaned before treatment. Excessive hair should be removed. A sufficient amount of the drug should be applied to cover the treatment area. The drug should be administered twice daily for 7 to 14 days.

Topical

If hypersensitivity to any of the components occurs treatment with this product should be discontinued and appropriate therapy instituted. Concomitant use with other drugs known to induce ototoxicity is not recommended. This preparation should not be used in conditions where corticosteroids are contraindicated. Do not administer parenteral corticosteroids during treatment with this drug. The antibiotic sensitivity of the pathogenic organism should be determined prior to use of this preparation. For use by or on the order of a licensed veterinarian.

VET BETA-GEN®

Two milligrams of gentamicin per pound of body weight, twice daily on the first day, once daily thereafter, using a 50 milligram-per-milliliter solution. Administer intramuscularly or subcutaneously.

Subcutaneous, Intramuscular

If response is not noted after 7 days, the antibiotic sensitivity of the infecting organism should be retested. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Gentocin® Solution

Apply a sufficient amount of the drug to cover the treatment area twice daily for 7 to 14 days.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Gentocin® Otic Solution

Apply approximately a 1/2 inch strip to the affected eye 2 to 4 times a day.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Vetro-Gen™ Veterinary Ophthalmic Ointment

1 or 2 drops instilled into the conjuctival sac 2 to 4 times a day

Ophthalmic

Gentocin® Ophthalmic Solution

Turkey (eggs)

The drug is added to clean water to provide a dip solution with a gentamicin concentration of 250 to 1,000 parts per million. A concentration of 500 parts per million is recommended. Clean eggs should be held submerged in the gentamicin solution under a vacuum of about 27.5 to 38 centimeters of mercury for 5 minutes followed by additional soaking in gentamicin solution for approximately 10 minutes at atmospheric pressure. Eggs can also be treated by warming them for 3 to 6 hours at approximately 100 °F then immediately dipping them in gentamicin solution maintained at about 40 °F, and held completely submerged for 10 to 15minutes.

Immersion

For use in the dipping treatment of turkey-hatching eggs only. Eggs which have been dipped in the drug shall not be used for food.

Garasol® Solution

Turkey (eggs)

The drug is added to clean water to provide a dip solution with a gentamicin concentration of 250 to 1,000 parts per million. A concentration of 500 parts per million is recommended. Clean eggs should be held submerged in the gentamicin solution under a vacuum of about 27.5 to 38 centimeters of mercury for 5 minutes followed by additional soaking in gentamicin solution for approximately 10 minutes at atmospheric pressure. Eggs can also be treated by warming them for 3 to 4 hours at approximately 40 degrees F, keeping eggs submerged for 10- 15 minutes.

Immersion

For use in the dipping treatment of turkey-hatching eggs only. Eggs which have been dipped in the drug shall not be used for food.

Gentasol

Turkeys (1 to 3 day old poults)

One milligram of gentamicin per 0.2 milliliter dose, using the 50-100-milligrams-per-milliliter product diluted with sterile saline to a concentration of 5 milligrams-per-milliliter.

Subcutaneous

For 1 to 3 day old turkey poults. Administer subcutaneously in the neck. Injected poults must not be slaughtered for food for at least 9 weeks after treatment.

Genta-Ject®

Turkeys (1- to 3-day old poults)

One milligram of gentamicin per poult, using a 5 milligram-per-milliliter solution. Administer subcutaneously in the neck.

Subcutaneous

For 1- to 3-day old turkey poults.

Garasol® Injection

Turkeys (1- to 3-day-old poults)

One milligram of gentamicin per poult, using a 5 milligram-per-milliliter solution. Administer subcutaneously in the neck.

Subcutaneous

Injected poults must not be slaughtered for food for at least 9 weeks after treatment.

Garasol®

One (1) milligram of gentamicin per 0.2 milliliter dose.

Subcutaneous

GentaMed™-P

Chickens (day-old)

0.2 milligram of gentamicin per 0.2 milliliter dose, using a 50 milligram-per-milliliter solution diluted with sterile physiological saline to 1.0 milligram per milliliter. Administer aseptically injecting the diluted product subcutaneously in the neck.

Subcutaneous

For use in day-old chickens only. Do not slaughter treated animals for food for at least 5 weeks after treatment.

Garasol®

Chickens (day-old)

0.2 milligram of gentamicin per 0.2 milliliter dose, using a 50 milligram-per-milliliter solution diluted with sterile physiological saline to 1.0 milligram per milliliter.

Subcutaneous

Do not slaughter treated animals for food for at least 5 weeks after treatment. Administer aseptically injecting the diluted product subcutaneously in the neck.

Genta-Ject®

Chickens (1 day old chicks)

0.2 milligram of gentamicin per 0.2 milliliter dose, using a 50 milligram-per-milliliter solution diluted with sterile physiological saline to 1.0 milligram per milliliter.

Subcutaneous

Do not slaughter treated animals for food for at least 5 weeks after treatment. Administer aseptically injecting the diluted product subcutaneously in the neck.

GentaPoult

0.2 milligram of gentamicin per 0.2 milliliter dose.

Subcutaneous

GentaMed™-P

Horses (mares)

It is administered at a dosage level of 2 to 2.5 grams per day for 3 to 5 days during estrus, each dose being diluted with 200 to 500 milliliters of sterile physiological saline before aseptic infusion into the uterus.

Intrauterine

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption.

Gentamex™ 100

It is administered at a dosage level of 2 to 2.5 grams per day for 3 to 5 days during estrus, each dose being diluted with 200 to 500 milliliters of sterile physiological saline before aseptic infusion into the uterus.

Intrauterine

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption

Gentamicin Sulfate Solution

One actuation of the sprayer delivers 0.7 milliliter containing 0.75 milligram gentamicin. The sprayer should be held upright 3 to 6 inches from the affected eye, with the opening directed towards the eye, and pumped once. It is advisable to treat once a day for up to 3 days.

Ophthalmic

Gentocin® Pink Eye Spray

DOSAGE AND ADMINISTRATION: GentaMed Soluble Powder is available in a 360 gram jar. The 360 gram jar contains a scoop that provides approximately 18 grams of product when level full. For Control and treatment of Colibacillosis-Administer GentaMed Soluble Powder in drinking water at the recommended level of 25 mg per gallon (1 scoop/240 gallons) for three consecutive days. For Control and treatment of Swine Dysentery-Administer GentaMed Soluble Powder in drinking water at the recommended level of 50 mg per gallon (1 scoop/120 gallons) for three consecutive days. The concentration of the medication should be adjusted in extremely hot or cold weather to ensure a gentamicin dosage of approximately 0.5 mg/lb/day for 3 days for colibacillosis or 1.0 mg/lb/day for 3 days for swine dysentery. A 50-lb pig will, under average conditions, consume 0.9 gallons of water per day. For swine dysentery, if the condition recurs, the medication may be repeated. Because of the tendency for the disease to recur on a premise with a history of swine dysentery, a control program should be used following treatment. DIRECTIONS FOR USE: To prepare medicated water, mix GentaMed Soluble Powder and drinking water according to the following tables: Proportioner Use: For Control and Treatment of Colibacillosis Add 18 g (1 scoop) GentaMed Soluble Powder to 2 gallons of water to make stock solution and dispense at the rate of one ounce per gallon of drinking water. This will result in drinking water that contains 25 mg/gallon. For Control and Treatment of Swine Dysentery Add 18 g (1 scoop) GentaMed Soluble Powder to 1 gallon of water to make stock solution and dispense at the rate of one ounce per gallon of drinking water. This will result in drinking water that contains 50 mg/gallon. Bulk Preparation: For Control and Treatment of Colibacillosis Add 18 g (1 scoop) GentaMed Soluble Powder to 240 gallons of water. For Control and Treatment of Swine Dysentery Add 18 g (1 scoop) GentaMed Soluble powder to 120 gallons of water. Medicated drinking water should not be stored or offered in rusty containers since the drug is quickly destroyed in such containers. Medicated water should be prepared daily and be the sole source of drinking water for 3 consecutive days. The daily water consumption figures shown below are approximations for mild temperatures and are presented as a guide only. Actual water consumption varies with environmental temperature, humidity, and diet. Approximate Daily Water Consumption Weight of Pig(lb) Gallon for 5 Pigs Gallons for 10 Pigs 25 3.0 6.0 50 4.5 9.0 75 6.0 12.0 100 7.5 15.0

ORAL

FDA application 200-494

DOSAGE AND ADMINISTRATION: Mometamax Single should be administered by veterinary personnel. The dose volume is 0.8 mL per affected ear. Verify the tympanic membrane is intact prior to administration (see Contraindications, Animal Safety Warnings and Precautions ). 1.Clean and dry the external ear canal before administering the product. 2. Shake bottle vigorously for 15 seconds. 3.Before first use, unwrap the syringe with the attached adapter. 4.Remove the cap from the bottle and insert the syringe with the attached adapter by pressing it firmly into the top of the bottle using the attached syringe (see figure A ). 5.Invert the bottle and draw up 0.8 mL (see figure B ). 6.Return the bottle to an upright position and remove the syringe from the adapter. Leave the adapter in place in the bottle for all subsequent uses. 7.Replace the cap on the bottle. 8.Place the tip of the syringe at the entrance of the external ear canal and administer the 0.8 mL dose (see figure C ). The applied dose will flow into the ear canal. 9.Gently massage the base of the ear to ensure distribution of the product throughout the ear canal. 10. Restrain the dog post-application to minimize head shaking and to reduce potential splatter of product and accidental eye exposure in people and dogs. 11.Use a new syringe for each affected ear. Shake the bottle vigorously (with the cap on the bottle to prevent leakage) for 15 seconds before drawing up each new dose. 12.The duration of the effect should last 33 days. Cleaning the ear after dosing may affect product effectiveness. 13.Only twenty doses can be accurately withdrawn from the bottle. Discard the bottle 3 months after opening or after 20 doses, whichever comes first.

AURICULAR (OTIC)

Mometamax Single™ (gentamicin, posaconazole, andmometasone furoate otic suspension)

DOSAGE AND ADMINISTRATION: GEN-GARD Soluble Powder is available in a 360 gram jar. The 360 gram jar contains a scoop that provides approximately 18 grams of product when level full. For Control and Treatment of Colibacillosis - Administer GEN-GARD Soluble Powder in drinking water at the recommended level of 25 mg per gallon (1 scoop/240 gallons) for three consecutive days. For Control and Treatment of Swine Dysentery - Administer GEN-GARD Soluble Powder in drinking water at the recommended level of 50 mg per gallon (1 scoop/120 gallons) for three consecutive days. The concentration of the medication should be adjusted in extremely hot or cold weather to ensure a gentamicin dosage of approximately 0.5 mg/lb/day for 3 days for colibacillosis or 1.0 mg/lb/day for 3 days for swine dysentery. A 50-lb pig will, under average conditions, consume 0.9 gallon of water per day. For swine dysentery, if the condition recurs, the medication may be repeated. Because of the tendency for the disease to recur on a premise with a history of swine dysentery, a control program should be used following treatment.

oral

FDA application 200-185

DOSAGE AND ADMINISTRATION: The external ear should be thoroughly cleaned and dried before treatment. Remove foreign material, debris, crusted exudates, etc., with suitable nonirritating solutions. Excessive hair should be clipped from the treatment area. After verifying that the eardrum is intact, instill 4 drops from the 7.5 g and 15 g tube, and 15 g and 30 g bottle (2 drops from the 215 g bottle) of OTOMAX ointment twice daily into the ear canal of dogs weighing less than 30 lbs. Instill 8 drops from the 7.5 g and 15 g tube, and 15 g and 30 g bottle (4 drops from the 215 g bottle) twice daily into the ear canal of dogs weighing 30 lbs or more. Massage external ear canal carefully after instillation to ensure appropriate distribution of medication. Therapy should continue for 7 consecutive days.

AURICULAR (OTIC)

Otomax® (GENTAMICIN SULFATE, BETAMETHASONE VALERATE, AND CLOTRIMAZOLE, OINTMENT)

DOS AGE AN D ADMINISTRATION: The external ear canal should be thoroughly cleaned and dried before treatment. Verify that the eardrum is intact. For dogs weighing less than 30 lbs, instill 4 drops from the 7.5 g tubes and bottles, 15 g tubes and bottles, and 30 g bottles (2 drops from the 215 g bottle) of Mometavet™ Otic Suspension once daily into the ear canal. For dogs weighing 30 lbs or more, instill 8 drops from the 7.5 g tubes and bottles, 15 g tubes and bottles, and 30 g bottles (4 drops from the 215 g bottle) once daily into the ear canal. Therapy should continue for 7 consecutive days.

AURICULAR (OTIC)

MOMETAVETTM (gentamicin sulfate, mometasone furoate anhydrous, and clotriamzole Otic Suspension)

DOSAGE AND ADMINISTRATION The topical application of GENTOCIN DURAFILM Ophthalmic Solution should, in each instance, be administered to meet the specific needs of the individual case. One or two drops of the solution may be instilled into the conjunctival sac three or four times a day. Thereafter, the frequency of the dosage may be reduced but care should be taken not to discontinue therapy prematurely. In chronic conditions, withdrawal of treatment should be carried out by gradually decreasing the frequency of application.

OPHTHALMIC

Gentocin® Durafilm® (gentamicin sulfate and betamethasone acetate ophthalmic solution)

Verify that the tympanic membrane is intact. Shake well before each use. Priming the canister: Prior to the first use of the dosing container, press firmly on the pump several times, ensuring the pump goes all the way down, until the nozzle (cannula) fills with a full dose of product. Once the nozzle is filled with product it is ready for administration. Carefully insert the cannula into the aected external ear canal(s) and apply 1 mL (a single pump) of EASOTIC Otic Suspension once per day for 5 days. Wash hands aer usage.

AURICULAR (OTIC)

EASOTIC® (hydrocortisone aceponate, miconazole nitrate, gentamicin sulfate) Otic Suspension for Dogs

The recommended dose is 1 mL (5 mg) administered intramuscularly. Gentamicin Piglet Injection is not to be used more than once in each piglet. If piglets do not respond to treatment with Gentamicin Piglet Injection, diagnosis should be reevaluated. Clean and sterilize needles and syringes by boiling in water for 15 minutes prior to use. Prior to injection, disinfect the injection site and top the vial with a suitable disinfectant, such as 70% alcohol. Use all precautions to prevent contamination of vial contents.

INTRAMUSCULAR

Gentamicin Piglet Injection (GENTAMICIN SULFATE, USP) Piglet Injection - 5 mg/mL

The external ear canal should be thoroughly cleaned and dried before treatment. Verify that the eardrum is intact. For dogs weighing less than 30 lbs, instill 4 drops from the 7.5 g, 15 g, and 30 g bottles (2 drops from the 215 g bottle) of MotaZol™ Otic Suspension once daily into the ear canal. For dogs weighing 30 lbs or more, instill 8 drops from the 7.5 g, 15 g, and 30 g bottles (4 drops from the 215 g bottle) once daily into the ear canal. Therapy should continue for 7 consecutive days.

AURICULAR (OTIC)

VET one® MotaZol™ (GENTAMICIN SULFATE, MOMETASONE FUROATE MONOHYDRATE, AND CLOTRIMAZOLE, OTIC SUSPENSION)

DOSE: Colibacillosis - 1 level scoop per 240 gallons of drinking water for 3 consecutive days, 0.5 mg/lb/day. For proportioner use, add 1 level scoop to 2 gallons stock solution and dispense at the rate of 1 oz./gal. drinking water (25 mg/gal.). Swine Dysentery - 1 level scoop per 120 gallons of drinking water for 3 consecutive days, 1.0 mg/lb/day. For proportioner use, add 1 level scoop to 1 gallon stock solution and dispense at the rate of 1 oz./gal. drinking water (50 mg/gal.).

oral

FDA application 200-185

FOR TOPICAL USE IN DOGS ONLY Prior to treatment, remove excessive hair and clean the lesion and adjacent area. Hold bottle upright 3 to 6 inches from the lesion and depress the sprayer head twice. Administer 2 to 4 times daily for 7 days. Each depression of the sprayer head delivers 0.7 mL of Gentamicin sulfate, USP with betamethasone valerate, USP.

TOPICAL

Gentamicin Sulfate With Betamethasone Valerate TOPICAL SPRAY

Prior to treatment, remove excessive hair and clean the lesion and adjacent area. Hold bottle upright 3 to 6 inches from the lesion and depress the sprayer head twice. Administer 2 to 4 times daily for 7 days. Each depression of the sprayer head delivers 0.7 mL of GENTACALM® Topical Spray.

TOPICAL

GENTACALM®​ Topical Spray

The recommended dose is 20 to 25 mL (2.0 - 2.5 grams) gentamicin sulfate solution per day for 3 to 5 days during estrus. Each dose should be diluted with 200-500 mL of sterile physiological saline before aseptic uterine infusion.

INTRAUTERINE

GENTAMICIN SULFATE SOLUTION 100 mg/mL

Usual Dosage: Two depressions of the sprayer head 2 to 4 times daily for 7 days.

TOPICAL

GENTACALM®​ Topical Spray

Instill 1 or 2 drops into the conjunctival sac 2 to 4 times a day

Ophthalmic

Federal law restricts this drug to use by or on the order of a licensed veterinarian

Gentamicin Sulfate Ophthalmic Solution