Ivermectin

For the effective treatment and control of these parasites. Gastrointestinal Roundworms- Ostertagia ostertagi (adults and L4) (including inhibited stage), Haemonchus placei (adults and L4), Trichostrongylus axei (adults and L4), T. colubriformis (adults and L4), Cooperia oncophora. (adults and L4), Cooperia punctata (adults and L4), Cooperia surnabada (adults and L4), Strongyloides papillosus (adults only), Oesophagostomum radiatum (adults and L4), and Trichuris spp. (adults only) Lungworms- Dictyocaulus viviparus (adults and L4) Cattle Grubs (parasitic stages)- Hypoderma bovis and H. lineatum Mites- Sarcoptes scabiei var. bovis Lice- Linognathus vituli, Haematopinus eurysternus, Damalinia bovis, and Solenopotes capillatus Horn Flies- Haematobia irritans Persistent Activity- Privermectin® Pour-On for Cattle (ivermectin) has been proved to effectively control infections and to protect cattle from reinfection with: Oesophagostomum radiatum and Dictyocaulus viviparus for 28 days after treatment; Cooperia punctata and Trichostrongylus axei for 21 days after treatment; Ostertagia ostertagi, Haemonchus placei, Cooperia oncophora and Cooperia surnabada for 14 days after treatment; Damalinia bovis for 56 days after treatment. Treatment of Cattle for Horn Flies- Privermectin® Pour-On for Cattle (ivermectin) controls horn flies (Haematobia irritans) for up to 28 days after dosing.

Do not use on calves to be processed for veal.

Privermectin®

It is used topically for the treatment and control of: Gastrointestinal roundworms (adults and fourth-stage larvae) Ostertagia ostertagi (including inhibited stage), Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, Cooperia punctata, Cooperia surnabada, Oesophagostomum radiatum; (adults) O. venulosum, Strongyloides papillosus, Trichuris species; lungworms (adults and fourth-stage larvae) Dictyocaulus viviparus; cattle grubs (parasitic stages) Hypoderma bovis, H. lineatum; mites Chorioptes bovis, Sarcoptes scabei var. bovis; lice Linognathus vituli, Haematopinus eurysternus, Damalinia bovis, Solenoptes capillatus; horn flies Haematobia irritans. It is also used to control infections of gastrointestinal roundworms O. ostertagi, O. radiatum, H. placei, T. axei, Cooperia punctata, and C. oncophora for 14 days after treatment. It has been proven to effectively control infections and to protect cattle from re-infection with: Oesophagostomum radiatum and Dictyocaulus viviparous for 28 days after treatment; Cooperia punctata and Trichostrongylus axei for 21 days after treatment; Ostertagia ostertagi, Haemonchus placei, Cooperia oncophora and Cooperia surnabada for 14 days after treatment; Damalinia bovis for 56 days after treatment.

Do not treat cattle within 48 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product on preruminating cales. Do not use on calves to be processed for veal.

Bimectin® Pour-On

SparMectin Plus Clorsulon is indicated for the effective treatment and control of the following parasites of cattle: Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi (including inhibited O. ostertagi) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis Cooperia oncophora C. punctata C. pectinata Bunostomum phlebotomum Nematodirus helvetianus (adults only) N. spathiger (adults only) Oesophagostomum radiatum Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus Liver Flukes: Fasciola hepatica (adults only) Cattle Grubs (parasitic stages): Hypoderma bovis H. lineatum Sucking Lice: Linognathus vituli Haematopinus eurysternus Solenopotes capillatus Mange Mites: (cattle scab*): Psoroptes ovis (syn. P. communis var. bovis) Sarcoptes scabiei var. bovis SparMectin Plus Clorsulon has been proved to effectively control infections and to protect cattle from reinfection with Dictyocaulus viviparus and Oesophagostomum radiatum for 28 days after treatment; Ostertagia ostertagi, Trichostrongylus axei and Cooperia punctata for 21 days after treatment; Haemonchus placei, and Cooperia oncophora for 14 days after treatment.

For subcutaneous use only. Not for intravenous or intramuscular use. Do not use in other animal species because severe adverse reactions, including fatalities in dogs, may result.

SparMectin Plus Clorsulon

It is used for the treatment and control of gastrointestinal nematodes (adults and fourth-stage larvae) (Haemonchus placei, Ostertagia ostertagi (including inhibited larvae), O. lyrata, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, C. pectinata, Oesophagostomum radiatum, Nematodirus helvetianus (adults only), N. spathiger (adults only), Bunostomum phlebotomum; lungworms (adults and fourth-stage larvae) (Dictyocaulus viviparus); liver flukes (adults only) (Fasciola hepatica); grubs (parasitic stages) (Hypoderma bovis, H. lineatum); lice (Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus); mites (Psoroptes ovis (syn. P. communis var. bovis), Sarcoptes scabiei var. bovis). It is also used to control infections of D. viviparus and O. radiatum for 28 days after treatment and O. ostertagi, T. axei and C. punctata for 21 days after treatment, and H. placei and C. oncophora, for 14 days after treatment.

For subcutaneous use only. Not for intravenous or intramuscular use. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. Do not use in other animal species because severe adverse reactions, including fatalities in dogs, may result. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Noromectin® Plus

For the treatment and control of gastrointestinal roundworms (adults and fourth-stage larvae) (Haemonchus placei, Ostertagia ostertagi (including inhibited larvae), O. lyrata, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, C. pectinata, Oesophagostomum radiatum, Nematodirus helvetianus (adults only), N. spathiger (adults only), Bunostomum phlebotomum; lungworms (adults and fourth-stage larvae) Dictyocaulus viviparus; grubs (parasitic stages) (Hypoderma bovis, H. lineatum); sucking lice (Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus); mites (scabies) (Psoroptes ovis (syn. P. communis var. bovis), Sarcoptes scabiei var. bovis). Persistent activity: For control of infections and to protect from reinfection with D. viviparus and O. radiatum for 28 days after treatment; O. ostertagi , T. axei, and C. punctata for 21 days after treatment; H. placei and C. oncophora for 14 days after treatment.

Do not use in calves to be processed for veal. For subcutaneous use only.

Phoenectin®

For the treatment and control of: Gastrointestinal roundworms (adults and fourth-stage larvae) Ostertagia ostertagi (including inhibited stage), Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, C. surnabada, Oesophagostomum radiatum; (adults) Strongyloides papillosus, Trichuris spp. ; lungworms (adults and fourth-stage larvae) Dictyocaulus viviparus; cattle grubs (parasitic stages) Hypoderma bovis, H. lineatum; mites Sarcoptes scabiei var. bovis; lice Linognathus vituli, Haematopinus eurysternus, Damalinia bovis, Solenoptes capillatus; and horn flies Haematobia irritans. It controls infections and prevents reinfection with O. radiatum and D. viviparus for 28 days after treatment, C. punctata and T. axei for 21 days after treatment, H. placei, C. oncophora, Ostertagia ostertagi, and C. surnabada for 14 days after treatment, and D. bovis for 56 days after treatment.

Do not treat cattle within 48 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product on preruminating cales. Do not use on calves to be processed for veal.

Noromectin® Pour-On for Cattle

It is used topically for the treatment and control of: Gastrointestinal roundworms (adults and fourth-stage larvae) Ostertagia ostertagi (including inhibited stage), Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia species, Oesophagostomum radiatum; (adults), Strongyloides papillosus, Trichuris species; lungworms (adults and fourth-stage larvae) Dictyocaulus viviparous; cattle grubs (parasitic stages) Hypoderma bovis, H. lineatum; mites Sarcoptes scabei var. bovis; lice Linognathus vituli, Haematopinus eurysternus, Damalinia bovis, Solenoptes capillatus; horn flies Haematobia irritans. It also controls infections and prevents reinfection with O. radiatum and D. viviparous for 28 days after treatment, C. punctate and T. axei for 21 days after treatment, H. placei, C. oncophora, and C. surnabada for 14 days after treatment, and D. bovis for 56 days after treatment.

Do not treat cattle within 48 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product on preruminating cales. Do not use on calves to be processed for veal.

Ivomec® Pour-On

It is used topically for the treatment and control of: Gastrointestinal roundworms (adults and fourth-stage larvae) Ostertagia ostertagi (including inhibited stage), Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia (Cooperia oncophora , C. punctata , C. surnabada), Oesophagostomum radiatum; (adults) O. venulosum, Strongyloides papillosus, Trichuris species; lungworms (adults and fourth-stage larvae) Dictyocaulus viviparus; cattle grubs (parasitic stages) Hypoderma bovis, H. lineatum; mites Chorioptes bovis, Sarcoptes scabei var. bovis; lice Linognathus vituli, Haematopinus eurysternus, Damalinia bovis, Solenoptes capillatus; horn flies Haematobia irritans. It is also used to control infections of gastrointestinal roundworms O. ostertagi, O. radiatum, H. placei, T. axei, Cooperia punctata, and C. oncophora for 14 days after treatment.

Do not treat cattle within 48 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product on preruminating calves. Do not use on calves to be processed for veal.

Ivermectin Pour-On for Cattle

It is used in cattle for the treatment and control of gastrointestinal roundworms (adults and fourth-stage larvae) (Ostertagia ostertagi (including inhibited forms), O. lyrata, Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, Nematodirus helvetianus, Bunostomum phlebotomum, Strongyloides papillosus (adults only), Oesophagostomum radiatum, Trichuris ovis (adults only)); lungworms (adults and fourth-stage larvae) (Dictyocaulus viviparus); grubs (first, second and third instars) (Hypoderma bovis, H. lineatum); and sucking lice (Linognathus vituli, Haematopinus eurysternus).

For oral use only. Do not treat cattle within 24 days of slaughter. Because withdrawal time in milk has not been established, do not use in female dairy of breeding age. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

Ivomec® Cattle Paste 0.153%

Cattle, excluding veal calves

For the treatment and control of gastrointestinal nematodes (adults and fourth-stage larvae) (Haemonchus placei, Ostertagia ostertagi (including inhibited larvae), O. lyrata, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, C. pectinata, Oesophagostomum radiatum, Nematodirus helvetianus (adults only), N. spathiger (adults only), Bunostomum phlebotomum); lungworms (adults and fourth-stage larvae) Dictyocaulus viviparus); grubs (parasitic stages) (Hypoderma bovis, H. lineatum); sucking lice (Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus); mites (scabies) (Psoroptes ovis (syn. P. communis var. bovis), Sarcoptes scabiei var. bovis). To control infections and to protect from reinfection with D. viviparus and O. radiatum for 28 days after treatment; O. ostertagi, T. axei, and C. punctata for 21 days after treatment; H. placei and C. oncophora for 14 days after treatment.

Do not treat cattle within 35 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Noromectin®

Cattle (Calves, Ruminating)

For treatment and control, throughout the grazing season (approximately 130 days), of gastrointestinal roundworms Haemonchus placei, Ostertagia ostertagi (including inhibited fourth-stage larvae), Trichostrongylus axei, T. colubriformis, Cooperia species, Nematodirus helvetianus, Bunostomum phlebotomum, Oesophagostomum radiatum; lungworms Dictyocaulus viviparous; grub Hypoderma species; sucking lice Linognathus vituli, Solenopotes capillatus; mange mites Psoroptes ovis, Sarcoptes scabiei, and ticks Amblyomma americanum.

The bolus was specifically designed for use in cattle. Do not use in other animal species. Calves must be ruminating and older than 12 weeks of age. Do not administer to calves weighing less than 275 pounds (125 kilograms). Do not administer a damaged bolus. Because a milk withdrawal time has not been established, do not use in female dairy cattle of breeding age. Do not slaughter within 180 days of treatment. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

Ivomec® Sustained-Release Bolus for Cattle

Beef cattle and dairy cattle (except dairy cows)

It is used topically for the treatment and control of: Gastrointestinal roundworms (adults and fourth-stage larvae) Ostertagia ostertagi (including inhibited stage), Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, C. surnabada, Oesophagostomum radiatum; (adults) Strongyloides papillosus, Trichuris spp.; lungworms (adults and fourth-stage larvae) Dictyocaulus viviparus; cattle grubs (parasitic stages) Hypoderma bovis, H. lineatum; mites Sarcoptes scabiei var. bovis; lice Linognathus vituli, Haematopinus eurysternus, Damalinia bovis, Solenopotes capillatus; horn flies Haematobia irritans. It controls infections and prevents reinfection with O. radiatum and D. viviparus for 28 days after treatment, C. punctata and T. axei for 21 days after treatment, O. ostertagi, H. placei, C. oncophora, and C. surnabada for 14 days after treatment, and D. bovis for 56 days after treatment.

Ecomectin

Cattle (excluding veal calves)

For the treatment and control of gastrointestinal nematodes (adults and fourth-stage larvae) (Haemonchus placei, Ostertagia ostertagi (including inhibited larvae), O. lyrata, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, C. pectinata, Oesophagostomum radiatum, Nematodirus helvetianus (adults only), N. spathiger (adults only), Bunostomum phlebotomum); lungworms (adults and fourth-stage larvae) (Dictyocaulus viviparus); grubs (parasitic stages) (Hypoderma bovis, H. lineatum); sucking lice (Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus); mites (scabies) (Psoroptes ovis (syn. P. communis var. bovis), Sarcoptes scabiei var. bovis). For control of infections and to protect from reinfection with D. viviparus and O. radiatum for 28 days after treatment; O. ostertagi, T. axei, and C. punctata for 21 days after treatment; H. placei and C. oncophora for 14 days after treatment. Limitations: Do not use in calves to be processed for veal.

Do not use in calves to be processed for veal.

Ivermectin Injection

For the treatment and control of gastrointestinal roundworms (Ascaris suum, adults and fourth-stage larvae; Ascarops strongylina, adults; Hyostrongylus rubidus, adults and fourth-stage larvae; Oesophagostomum species, adults and fourth-stage larvae), kidneyworms (Stephanurus dentatus, adults and fourth-stage larvae), lungworms (Metastrongylus species, adults), lice (Haematopinus suis), and mange mites (Sarcoptes scabiei var. suis). For control of swine dysentery; for use in swine on premises with a history of swine dysentery, but where symptoms have not yet occurred.

Feed as the only feed for 7 consecutive days. Continue by feeding a separate feed containing 40 grams lincomycin/ton to complete the lincomycin treatment. Withdraw 5 days before slaughter. Not to be fed to swine that weigh more than 250 pounds. This product is for use in swine only. This product should not be used for other animal species. Occasionally swine fed lincomycin may within the first two days after the onset of treatment develop diarrhea and/or swelling of the anus. On rare occasions, some pigs may show reddening of the skin and irritable behavior. These conditions have been self-correcting within five to eight days without discontinuing the lincomycin treatment. Do not allow rabbits, hamsters, guinea pigs, horses, or ruminants access to feeds containing lincomycin. Ingestion by these species may result in severe gastrointestinal effects.

IVOMEC® plus LINCOMIX®

For the treatment and control of gastrointestinal roundworms (Ascaris suum, adults and fourth-stage larvae; Ascarops strongylina, adults; Hyostrongylus rubidus, adults and fourth-stage larvae; Oesophagostomum spp., adult and fourth-stage larvae), kidneyworms (Stephanurus dentatus, adults and fourth-stage larvae), lungworms (Metastrongylus spp., adults);lice (Haematopinus suis) and mange mites (Sarcoptes scabiei var. suis). For reduction in severity of swine mycoplasmal pneumonia caused by Mycoplasma hyopneumoniae.

Feed as the only feed for 7 consecutive days. Follow by a separate feed containing 200 grams per ton lincomycin for an additional 14 days to complete the lincomycin treatment. Withdraw 6 days before slaughter. Not to be fed to swine that weigh more than 250 pounds. This product is for use in swine only. This product should not be used for other animal species. Occasionally swine fed lincomycin may within the first two days after the onset of treatment develop diarrhea and/or swelling of the anus. On rare occasions, some pigs may show reddening of the skin and irritable behavior. These conditions have been self-correcting within five to eight days without discontinuing the lincomycin treatment. Do not allow rabbits, hamsters, guinea pigs, horses, or ruminants access to feeds containing lincomycin. Ingestion by these species may result in severe gastrointestinal effects.

IVOMEC® plus LINCOMIX®

Used in swine for treatment and control of gastrointestinal roundworms (adults and fourth-stage larvae) (large roundworm, Ascaris suum; red stomach worm, Hyostrongylus rubidus; nodular worm, Oesophagostomum species; threadworm, Strongyloides ransomi (adults only)); somatic roundworm larvae (threadworm, Strongyloides ransomi (somatic larvae)); lungworms (Metastrongylus species (adults only)); lice (Haematopinus suis); and mites (Sarcoptes scabiei var. suis).

Do not treat swine within 18 days of slaughter.

Noromectin®

For the treatment and control of gastrointestinal roundworms (Ascaris suum, adults and fourth-stage larvae; Ascarops strongylina, adults; Hyostrongylus rubidus, adults and fourth-stage larvae; Oesophagostomum spp., adult and fourth-stage larvae), kidneyworms (Stephanurus dentatus, adults and fourth-stage larvae), lungworms (Metastrongylus spp., adults); lice (Haematopinus suis) and mange mites (Sarcoptes scabiei var. suis). Treatment of swine dysentery.

Feed as the only feed for 7 consecutive days. Continue by feeding a separate feed containing 100 grams lincomycin/ton to complete the lincomycin treatment. Withdraw 6 days before slaughter. Not to be fed to swine that weigh more than 250 pounds. This product is for use in swine only. This product should not be used for other animal species. Occasionally swine fed lincomycin may within the first two days after the onset of treatment develop diarrhea and/or swelling of the anus. On rare occasions, some pigs may show reddening of the skin and irritable behavior. These conditions have been self-correcting within five to eight days without discontinuing the lincomycin treatment. Do not allow rabbits, hamsters, guinea pigs, horses, or ruminants access to feeds containing lincomycin. Ingestion by these species may result in severe gastrointestinal effects.

IVOMEC® plus LINCOMIX®

For the treatment and control of gastrointestinal roundworms (adults and fourth-stage larvae) (large roundworm, Ascaris suum; red stomach worm, Hyostrongylus rubidus; nodular worm, Oesophagostomum spp.; threadworm, Strongyloides ransomi (adults only)); somatic roundworm larvae (threadworm, S. ransomi (somatic larvae)); lungworms (Metastrongylus spp. (adults only)); lice (H. suis); and mites (S. scabiei var. suis).

Ivermectin Injection

Swine (Growing-Finishing)

For the treatment and control of gastrointestinal roundworms (Ascaris suum, adults and fourth-stage larvae; Ascarops strongylina, adults; Hyostrongylus rubidus, adults and fourth-stage larvae; Oesophagostomum species, adults and fourth-stage larvae), kidneyworms (Stephanurus dentatus, adults and fourth-stage larvae), lungworms (Metastrongylus species, adults), lice (Haematopinus suis); and mange mites (Sarcoptes scabiei var. suis).

Feed as the only feed for 7 consecutive days. For use in swine only. Withdraw 5 days before slaughter.

Ivomec® Premix for Swine

Swine (Mature and Breeding)

For the treatment and control of gastrointestinal roundworms (Ascaris suum, adults and fourth-stage larvae; Ascarops strongylina, adults; Hyostrongylus rubidus, adults and fourth-stage larvae; Oesophagostomum species, adults and fourth-stage larvae), kidneyworms (Stephanurus dentatus, adults and fourth-stage larvae), lungworms (Metastrongylus species, adults), lice (Haematopinus suis); and mange mites (Sarcoptes scabiei var. suis).

Feed as the only feed for 7 consecutive days. For use in swine only. Withdraw 5 days before slaughter. in liquid feed supplements.

Ivomec® Premix for Swine

Weaned, Growing and Finishing Pigs

For the treatment and control of gastrointestinal roundworms (Ascaris suum, adults and fourth-stage larvae; Ascarops strongylina, adults; Hyostrongylus rubidus, adult and fourth-stage larvae; Oesophagostomum spp., adult and fourth-stage larvae), kidneyworms (Stephanurus dentatus, adults and fourth-stage larvae), lungworms (Metastrongylus spp., adults), threadworms (Strongyloides ransomi, adults and somatic larvae, and prevention of transmission of infective larvae to piglets, via colostrum or milk, when fed during gestation), lice (Haematopinus suis) and mange mites (Sarcoptes scabiei var. suis).

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.This product contains IVOMEC brand ivermectin and has been formulated specifically for use in swine only. This product should not be used for other animal species. Do not permit water runoff from swine production sites to directly enter lakes, streams, or ponds. Do not contaminate water by direct application or by the improper disposal of drug containers.

BMD® / Ivomec® Premix for Swine

Weaned, Growing and Finishing Pigs

For control of swine dysentery associated with Treponema hyodysenteriae on premises with a history of swine dysentery but where signs of disease have not yet occurred; or following an approved treatment of the disease condition.

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.This product contains IVOMEC brand ivermectin and has been formulated specifically for use in swine only. This product should not be used for other animal species. Do not permit water runoff from swine production sites to directly enter lakes, streams, or ponds. Do not contaminate water by direct application or by the improper disposal of drug containers.

BMD® / Ivomec® Premix for Swine

Weaned, Growing and Finishing Pigs

For increased rate of weight gain and improved feed efficiency in growing and finishing swine.

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.This product contains IVOMEC brand ivermectin and has been formulated specifically for use in swine only. This product should not be used for other animal species. Do not permit water runoff from swine production sites to directly enter lakes, streams, or ponds. Do not contaminate water by direct application or by the improper disposal of drug containers.

BMD® / Ivomec® Premix for Swine

Pregnant Sows

For the treatment and control of gastrointestinal roundworms (Ascaris suum, adults and fourth-stage larvae; Ascarops strongylina, adults; Hyostrongylus rubidus, adult and fourth-stage larvae; Oesophagostomum spp., adult and fourth-stage larvae), kidneyworms (Stephanurus dentatus, adults and fourth-stage larvae), lungworms (Metastrongylus spp., adults), threadworms (Strongyloides ransomi, adults and somatic larvae, and prevention of transmission of infective larvae to piglets, via colostrum or milk, when fed during gestation), lice (Haematopinus suis) and mange mites (Sarcoptes scabiei var. suis).

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.This product contains IVOMEC brand ivermectin and has been formulated specifically for use in swine only. This product should not be used for other animal species. Do not permit water runoff from swine production sites to directly enter lakes, streams, or ponds. Do not contaminate water by direct application or by the improper disposal of drug containers.

BMD® / Ivomec® Premix for Swine

Pregnant Sows

For control of clostridial enteritis caused by C. perfringens in suckling piglets.

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.This product contains IVOMEC brand ivermectin and has been formulated specifically for use in swine only. This product should not be used for other animal species. Do not permit water runoff from swine production sites to directly enter lakes, streams, or ponds. Do not contaminate water by direct application or by the improper disposal of drug containers.

BMD® / Ivomec® Premix for Swine

For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense), and tapeworms (Dipylidium caninum, Taenia pisiformis).

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

IVERHART MAX® Chew

To prevent canine heartworm disease by eliminating the tissue larval stages of Dirofilaria immitis for up to a month (30 days) after infection and treatment and control of adult ascarids Toxocara canis and Toxascaris leonina, and adult hookworms Ancylostoma caninum, A. braziliense, and Uncinaria stenocephala.

Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian.

Iverhart™ Plus Flavored Chewables

To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection. For the treatment and control of ascarids (Toxocara canis, Toxascaris leonine), and hookworms (Ancylostoma caninum, A braziliense, and Uncinaria stenocephala).

Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus.

Heartgard® Plus

Ivermectin: to prevent canine heartworm diseases by eliminating the tissue larval stage of Dirofilaria immitis for a month (30 days) after infection. Pyrantel pamoate: for the treatment and control of adult Toxocara canis, Toxascaris leonina, Ancylostoma caninum, A braziliense, and Uncinaria stenocephala.

Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian.

Tri-Heart Plus Chewable Tablets

For the treatment and control of adult Toxocara canis (roundworm), Ancylostoma caninum (hookworm), Trichuris vulpis (whipworm), and Dipylidium caninum (tapeworm), and for the prevention of heartworm disease caused by Dirofilaria immitis in adult dogs.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Panacur® Plus

For the prevention of heartworm disease caused by Dirofilaria immitis; kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis).

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Advantage® DUO

To prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for 1 month (30 days) after infection.

Use once-a-month. Recommended for dogs 6 weeks of age and older. Initial use within 1 month after first exposure to mosquitoes. Final use within 1 month after last exposure to mosquitoes. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Ivermectin Chewable Tablets

Dogs (12.1 - 25 Lbs)

Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonine), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and tapeworm (Dipylidium caninum, Taenia pisiformis) infections.

For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

IVERHART MAX®

Dogs (6.0 - 12 Lbs)

Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonine), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and tapeworm (Dipylidium caninum, Taenia pisiformis) infections.

For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

IVERHART MAX®

Dogs (50.1 - 100 Lbs)

Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonine), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and tapeworm (Dipylidium caninum, Taenia pisiformis) infections.

For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

IVERHART MAX®

Dogs (25.1 - 50 Lbs)

Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonine), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and tapeworm (Dipylidium caninum, Taenia pisiformis) infections.

For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

IVERHART MAX®

For treatment and control of the following parasites in horses: tapeworms--Anoplocephala perfoliata; large strongyles (adults)-- Strongylus vulgaris (also early forms in blood vessels), S. edentates (also tissue stages), S. equinus, Triodontophorus species including T. brevicauda and T. serratus, and Craterostomum acuticaudatum; small strongyles (adults, including those resistant to some benzimidazole class compounds)--Coronocyclus species including C. coronatus, C. labiatus, and C. labratus, Cyathostomum species including C. catinatum and C. pateratum, Cylicocyclus species including C. insigne, C. leptostomum, C. nassatus, and C. brevicapsulatus, Cylicodontophorus species, Cylicostephanus species including C. calicatus, C. goldi, C. longibursatus, and C. minutus, and Petrovinema poculatum; small strongyles-fourth-stage larvae; pinworms (adults and fourth stage larvae)--Oxyuris equi; Ascarids (adults and third- and fourth-stage larvae)--Parascaris equorum; hairworms (adults)--Trichostrongylus axei; large-mouth stomach worms (adults)--Habronema muscae; bots (oral and gastric stages)--Gasterophilus species including G. intestinalis and G. nasalis; lungworms (adults and fourth-stage larvae)--Dictyocaulus arnfieldi; intestinal threadworms (adults)--Strongyloides westeri; summer sores caused by Habronema and Draschia species cutaneous third-stage larvae; Dermatitis caused by neck threadworm microfilariae, Onchocerca species.

For oral use only. Do not use in horses intended for human consumption. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result.

ZIMECTERIN® Gold Paste

For the treatment and control of the following parasites in horses over 5 months of age: Tapeworms Anoplocephala perfoliata; Large Strongyles (adults) - Strongylus vulgaris (also early forms in blood vessels), S. edentatus (also tissue stages), S. equinus, Triodontophorus spp. including T. brevicauda and T. serratus, and Craterostomum acuticaudatum; Small Strongyles (adults, including those resistant to some benzimidazole class compounds) - Coronocyclus spp. including C. coronatus, C. labiatus and C. labratus; Cyathostomum spp. including C. catinatum and C. pateratum; Cylicocyclus spp. including C. insigne, C. leptostomum, C. nassatus and C. brevicapsulatus; Cylicodontophorus spp. Cylicostephanus spp. including C. calicatus, C. goldi, C. longibursatus and C. minutus, and Petrovinema poculatum; Small Strongyles - Fourth-stage larvae; Pinworms (adults and fourth-stage larvae)- Oxyuris equi; Ascarids (adults and third- and fourth-stage larvae) - Parascaris equorum; Hairworms (adults) - Trichostrongylus axei; Large-mouth Stomach Worms (adults) - Habronema muscae; Bots (oral and gastric stages) - Gasterophilus spp. including G. intestinalis and G. nasalis; Lungworms (adults and fourth-stage larvae) - Dictyocaulus arnfieldi; Intestinal Threadworms (adults) - Strongyloides westeri; Summer Sores caused by Habronema and Draschia spp. cutaneous third-stage larvae; Dermatitis caused by neck threadworm microfilariae, Onchocerca sp.

Do not use in horses intended for human consumption.

Duocare™

For treatment and control of: Large strongyles (adults)--Strongylus vulgaris (also early forms in blood vessels), S. edentatus (also tissue stages), S. equinus, and Triodontophorus spp. including T. brevicauda and T. serratus; Small Strongyles (adults, including those resistant to some benzimidazole class compounds)-- Cyathostomum spp. including C. catinatum and C. pateratum, Cylicocyclus spp. including C. insigne, C. leptostomum, C. nassatus, and C. brevicapsulatus, Cylicodontophorus spp., and Cylicostephanus spp. including C. calicatus, C. goldi, C. longibursatus, and C. minutus; Small Strongyles--fourth-stage larvae; Pinworms (adults and fourth-stage larvae)-- Oxyuris equi; Ascarids (adults and third- and fourth-stage larvae)-- Parascaris equorum; Hairworms (adults)-- Trichostrongylus axei; Large-mouth Stomach Worms (adults)-- Habronema muscae; Bots (oral and gastric stages)-- Gasterophilus spp. including G. intestinalis and G. nasalis; Lungworms (adults and fourth-stage larvae)-- Dictyocaulus arnfieldi; Intestinal Threadworms (adults)-- Strongyloides westeri; Summer Sores caused by Habronema and Draschia spp. cutaneous third-stage larvae; Dermatitis caused by neck threadworm microfilariae, Onchocerca sp.

For oral use only. Do not use in horses intended for human consumption.

Equell®

For treatment and control of the following parasites in horses: Tapeworms--Anoplocephala perfoliata; Large Strongyles (adults)--Strongylus vulgaris (also early forms in blood vessels), S.edentatus (also tissue stages), S. equinus, Triodontophorus spp.; Small Strongyles (adults, including those resistant to some benzimidazole class compounds)--Cyathostomum species, Cylicocyclus species, Cylicostephanus species, Cylicodontophorus species; Small Strongyles--fourth-stage larvae; Pinworms (adults and fourth-stage larvae)--Oxyuris equi; Ascarids (adults and third- and fourth-stage larvae)--Parascaris equorum; Hairworms (adults)--Trichostrongylus axei; Large-mouth Stomach Worms (adults)--Habronema muscae; Bots (oral and gastric stages)--Gasterophilus species; Lungworms (adults and fourth-stage larvae)--Dictyocaulus arnfieldi; Intestinal Threadworms (adults)--Strongyloides westeri; Summer Sores caused by Habronema and Draschia spp. cutaneous third-stage larvae; Dermatitis caused by neck threadworm microfilariae, Onchocerca species.

For oral use in horses only. Do not use in horses intended for human consumption. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result

Equimax®

Large Strongyles (Strongylus equinus (adult), S. vulgaris (adult and arterial larval stages), S. endentatus (adult and migrating tissue stages), Triodontophorus spp. (adult)); Small Strongyles including those resistant to some benzimidazole class compounds (Cyathostomum spp. (adult and fourth-stage larvae), Cylicocyclus spp., Cylicodontophorus spp., Cylicostephanus spp.); Pinworms (Oxyuris equi (adult and fourth-stage larvae)); Ascarids (Parascaris equorum (adult and third- and fourth-stage larvae)); Hairworms (Trichostongylus axei (adult)); Large mouth Stomach Worms (Habronema muscae (adult)); Stomach Bots (Gastrophilus spp. (oral and gastric stages)); Lungworms (Dictyocaulus arnfieldi (adult and fourth-stage larvae)); intestinal threadworms (Strongyloides westeri (adult)); Summer Sores caused by Habronema and Draschia spp. cutaneous third-stage larvae; and Dermatitis caused by neck threadworm microfilariae (Onchocerca spp.).

Do not use in horses intended for human consumption. Federal law restricts this drug to us by or on the order of a licensed veterinarian.

Primectin™ Equine Oral Liquid

It is used in horses for the treatment and control of large strongyles (adult) (Strongylus vulgaris, Strongylus edentatus, Triodontophorus species), small strongyles (adult and fourth stage larvae) (Cyathostomum species, Cylicocyclus species, Cylicostephanus species), pinworms (adult and fourth-stage larvae) (Oxyuris equi), large roundworms (adult) (Parascaris equorum), hairworms (adult) (Trichostrongylus axei), large mouth stomach worms (adult) (Habronema muscae), neck threadworms (microfilariae) (Onchocerca species), and stomach bots (Gastrophilus species).

Do not use intravenously. Not for use in horses intended for food. Effects of this drug on pregnant mares have not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Eqvalan® Injection

Reindeer

It is used in reindeer for treatment and control of warbles (Oedemagena tarandi).

For subcutaneous use only. Not for intramuscular use. Do not treat reindeer within 56 days of slaughter.

Noromectin®

Reindeer

For the treatment and control of warbles (Oedemagena tarandi).

Ivermectin Injection

It is used in Amer ican bison for the treatment and control of grubs (Hypoderma bovis).

For subcutaneous use. Do not slaughter within 56 days of last treatment. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

Bimectin® Injection for Cattle and Swine

For the treatment and control of grubs (Hypoderma bovis).

For subcutaneous use only.

Phoenectin®

Cats and Kittens (4 Weeks of Age and Older)

For the treatment of adult ear mite (Otodectes cynotis) infestations in cats and kittens 4 weeks of age and older. Effectiveness against eggs and immature stages has not been proven.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Acarexx®

Cats (6 Weeks of Age and Older)

To prevent feline heartworm disease by eliminating the tissue stage of heartworm larvae Dirofilaria immitis for a month (30 days) after infection, and for removal and control of adult and immature (L4) hookworms Ancylostoma tubaeforme and A. braziliense.

For use in cats 6 weeks of age and older. Administer once a month. The initial dose must be given within a month after cats first exposure to mosquitoes. The final dose must be given within a month after the cats last exposure to mosquitoes.

Heartgard® for Cats

For treatment and control of the adult and fourth-stage larvae of the following gastrointestinal roundworms - Haemonchus contortus, H. placei (adults only), Ostertagia circumcincta, Trichostrongylus axei, T. colubriformis, Cooperia oncophora (adults only), C. curticei, Oesophagostomum columbianum, O. venulosum (adults only), Nematodirus battus, N. spathiger, S. papillosus (adults only), Chabertia ovina (adult only), Trichuris ovis (adults only); lungworms (D. filaria); and all larval stages of the nasal bot Oestrus ovis.

For use in sheep only. Do not use in other animal species as severe adverse reactions, including fatalities in dogs, may result. Do not treat sheep within 11 days of slaughter.

Privermectin™ Drench for Sheep

For treatment and control of ear mites (Otodectes cynotis).

For subcutaneous use only. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

Ivomec® .27% Injection Grower And Feeder Pigs

For the treatment and control of grubs (Hypoderma bovis).

Ivermectin Injection

INDICATIONS Cattle: Vetrimec 1% Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, grubs, sucking lice, and mange mites in cattle: Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi (including inhibited O. ostertagi), O. lyrata, Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, C. pectinata, Oesophagostomum radiatum, Bunostomum phlebotomum, Nematodirus helvetianus (adults only), N. spathiger (adults only) Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus Cattle Grubs (parasitic stages): Hypoderma bovis, H. lineatum Sucking Lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus Mites (scabies): Psoroptes ovis (syn. P. communis var. bovis), Sarcoptes scabiei var. bovis Persistent Activity Ivermectin injection has been proved to effectively control infections and to protect cattle from reinfection with Dictyocaulus viviparus and Oesophagostomum radiatum for 28 days after treatment; Ostertagia ostertagi, Trichostrongylus axei and Cooperia punctata for 21 days after treatment; Haemonchus placei and Cooperia oncophora for 14 days after treatment. Swine: Vetrimec 1% Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, lice, and mange mites in swine: Gastrointestinal Roundworms: Large roundworms, Ascaris suum (adults and fourth-stage larvae), Red stomach worm, Hyostrongylus rubidus (adults and fourth-stage larvae), Nodular worm, Oesophagostomum spp. (adults and fourth-stage larvae), Threadworm, Strongyloides ransomi (adults) Somatic Roundworm Larvae: Threadworm, Strongyloides ransomi (somatic larvae) Sows must be treated at least seven days before farrowing to prevent infection in piglets. Lungworms: Metastrongylus spp. (adults) Lice: Haematopinus suis Mange Mites: Sarcoptes scabiei var. suis

FDA application 200-447

INDICATIONS Cattle: Bimectin Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, grubs, sucking lice, and mange mites in cattle: Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi (including inhibited O. ostertagi), O. lyrata, Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, C. pectinata, Oesophagostomum radiatum, Bunostomum phlebotomum, Nematodirus helvetianus (adults only), N. spathiger (adults only) Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus Cattle Grubs (parasitic stages): Hypoderma bovis, H. lineatum Sucking Lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus Mites (scabies): Psoroptes ovis (syn. P. communis var. bovis), Sarcoptes scabiei var. bovis Persistent Activity Ivermectin injection has been proved to effectively control infections and to protect cattle from reinfection with Dictyocaulus viviparus and Oesophagostomum radiatum for 28 days after treatment; Ostertagia ostertagi, Trichostrongylus axei and Cooperia punctata for 21 days after treatment; Haemonchus placei and Cooperia oncophora for 14 days after treatment. Swine: Bimectin Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, lice, and mange mites in swine Gastrointestinal Roundworms: Large roundworms, Ascaris suum (adults and fourth-stage larvae), Red stomach worm, Hyostrongylus rubidus (adults and fourth-stage larvae), Nodular worm, Oesophagostomum spp. (adults and fourth-stage larvae), Threadworm, Strongyloides ransomi (adults) Somatic Roundworm Larvae: Threadworm, Strongyloides ransomi (somatic larvae) Sows must be treated at least seven days before farrowing to prevent infection in piglets. Lungworms: Metastrongylus spp. (adults) Lice: Haematopinus suis Mange Mites: Sarcoptes scabiei var. suis

FDA application 200-447

INDICATIONS: Vetrimec™ Plus is indicated for the effective treatment and control of the following parasites in cattle: Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi (including inhibited O. ostertagi) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis Cooperia oncophora C. punctata C. pectinata Bunostomum phlebotomum Nematodirus helvetianus (adults only) N. spathiger (adults only) Oesophagostomum radiatum Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus Liver Flukes: Fasciola hepatica (adults only) Cattle Grubs (parasitic stages): Hypoderma bovis H. lineatum Sucking Lice: Linognathus vituli Haematopinus eurysternus Solenopotes capillatus Mange Mites (Cattle Scab*): Psoroptes ovis (syn. P. communis var. bovis) Sarcoptes scabiei var. bovis Persistent Activity: Ivermectin and clorsulon injection has been proved to effectively control infections and to protect cattle from reinfection with Dictyocaulus viviparus and Oesophagostomum radiatum for 28 days after treatment; Ostertagia ostertagi, Trichostrongylus axei and Cooperia punctata for 21 days after treatment; Haemonchus placei and Cooperia oncophora for 14 days after treatment. *Ivermectin has been approved as a scabicide by USDA/APHIS. Federal regulations require that cattle infested with or exposed to scabies (i.e., infestations with Psoroptes ovis) be treated. Ivermectin when used according to label instructions meets this requirement. Treated cattle may be shipped interstate, but they must not be mixed with other cattle for 14 days following treatment. The federal regulations make no restriction on the movement of cattle not affected with or exposed to scabies. However, individual states have additional regulations to govern the interstate shipment of cattle and the regulatory veterinarian in the state of destination should be consulted for applicable regulations on the use of ivermectin in the control of scabies.

FDA application 200-450

INDICATIONS ProMectin® B (ivermectin topical solution) Pour-On applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites. Gastrointestinal Roundworms Ostertagia ostertagi (adults and L4) (including inhibited stage) Haemonchus placei (adults and L4) Trichostrongylus axei (adults and L4) T. colubriformis (adults and L4) Cooperia oncophora (adults and L4) Cooperia punctate (adults and L4) Cooperia surnabada (adults and L4) Strongyloides papillosus (adults) Oesophagostomum radiatum (adults and L4) Trichuris spp. (adults) Lungworms Dictyocaulus viviparus (adults and L4) Cattle Grubs (parasitic stages) Hypoderma bovis H. lineatum Mites Sarcoptes scabiei var. bovis Lice Linognathus vituli Haematopinus eurysternus Damalinia bovis Solenopotes capillatus Horn Flies Haematobia irritans PERSISTENT ACTIVITY Ivermectin topical solution has been proved to effectively control infections and to protect cattle from re-infection with: Oesophagostomum radiatum and Dictyocaulus viviparus for 28 days after treatment; Cooperia punctata and Trichostrongylus axei for 21 days after treatment; Ostertagia ostertagi, Haemonchus placei, Cooperia oncophora and Cooperia surnabada for 14 days after treatment; Damalinia bovis for 56 days after treatment. TREATMENT OF CATTLE FOR HORN FLIES ProMectin® B (ivermectin topical solution) Pour-On controls horn flies (Haematobia irritans) for up to 28 days after dosing. For best results ProMectin® B (ivermectin topical solution) Pour-On should be part of a parasite control program for both internal and external parasites based on the epidemiology of these parasites. Consult your veterinarian or an entomologist for the most effective timing of applications.

FDA application 200-318

Ivermax® Pour-On for Cattle applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites. Gastrointestinal Roundworms Ostertagia ostertagi (including inhibited stage) (adults and L4) Haemonchus placei (adults and L4) Trichostrongylus axei (adults and L4) T. colubriformis (adults and L4) Cooperia oncophora (adults and L4) Cooperia punctate (adults and L4) Cooperia surnabada (adults and L4) Strongyloides papillosu (adults) Oesophagostomum radiatum (adults and L4) Trichuris spp. (adults) Lungworms Dictyocaulus viviparus (adults and L4) Cattle Grubs (parasitic stages) Hypoderma bovis H. lineatum Mites S arcoptes scabiei var. Bovis Lice Linognathus vituli Haematopinus eurystemus Damalinia bovis Solenopotes capillatus Horn Flies Haematobia irritan s Persistent Activity Ivermax® Pour-On for Cattle has been proved to effectively control infections and to protect cattle from re-infection with: Oesophagostomum radiatum and Dictyocaulus viviparous for 28 days after treatment; Cooperia punctata and Trichostrongylus axei for 21 days after treatment; Ostertagia ostertagi, Haemonchus placei, Cooperia oncophora and Cooperia surnabada for 14 days after treatment; Damalinia bovis for 56 days after treatment. TREATMENT OF CATTLE FOR HORN FLIES Ivermax® Pour-On for Cattle controls horn flies (Haematobia irritans) for up to 28 days after dosing. For best results Ivermax® Pour-On for Cattle should be part of a parasite control program for both internal and external parasites based on the epidemiology of these parasites. Consult your veterinarian or an entomologist for the most effective timing of applications.

Ivermax® Pour-On for Cattle(ivermectin topical solution)

SparMectin-E (ivermectin) Liquid is indicated for the effective treatment and control of the following parasites in horses. Large Strongyles (adults): Strongylus vulgaris (also early forms in blood vessels) Strongylus edentatus (also tissue stages) Strongylus equinus Triodontophorus spp. including: Triodontophorus brevicauda Triodontophorus serratus Craterostomum acuticaudatum Small Strongyles (adults, including those resistant to some benzimidazole class compounds): Coronocyclus spp. including: Coronocyclus coronatus Coronocyclus labiatus Coronocyclus labratus Cyathostomum spp. including: Cyathostomum catinatum Cyathostomum pateratum Cylicocyclus spp. including: Cylicocyclus insigne Cylicocyclus leptostomum Cylicocyclus nassatus Cylicocyclus brevicapsulatus Cylicodontophorus spp. Cylicostephanus spp. including: Cylicostephanus calicatus Cylicostephanus goldi Cylicostephanus longibursatus Cylicostephanus minutus Petrovinema poculatum Small Strongyles: Fourth-stage larvae Pinworms (adults and fourth-stage larvae) - Oxyuris equi Roundworms or ascarids (adults and third- and fourth-stage larvae) - Parascaris equorum Hairworms (adults) - Trichostrongylus axei Large-mouth Stomach worms (adults) - Habronema muscae Bots (oral and gastric stages) - Gasterophilus spp. including G. intestinalis and G. nasalis Lungworms (adults and fourth-stage larvae) - Dictyocaulus arnfieldi Intestinal threadworms (adults) - Strongyloides westeri Summer sores caused by Habronema and Draschia spp. cutaneous third-stage larvae; dermatitis caused by neck threadworm microfilariae, Onchocerca sp.

SparMectin-E

Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. ZIMECTERIN® GOLD (ivermectin/praziquantel) Paste provides effective treatment and control of the following parasites in horses. Tapeworms – Anoplocephala perfoliata, Large Strongyles (adults) – Strongylus vulgaris (also early forms in blood vessels), S. edentatus (also tissue stages), S. equinus, Triodontophorus spp. including T. brevicauda and T. serratus and Craterostomum acuticaudatum; Small Strongyles (adults, including those resistant to some benzimidazole class compounds) – Coronocyclus spp. including C. coronatus, C. labiatus and C. labratus, Cyathostomum spp. including C. catinatum and C. pateratum, Cylicocyclus spp. including C. insigne, C. leptostomum, C. nassatus, and C. brevicapsulatus, Cylicodontophorus spp., Cylicostephanus spp., including C. calicatus, C. goldi, C. longibursatus and C. minutus, and Petrovinema poculatum; Small Strongyles – Fourth-stage larvae; Pinworms (adults and fourth-stage larvae) – Oxyuris equi; Ascarids (adults and third- and fourth-stage larvae) – Parascaris equorum; Hairworms (adults) – Trichostrongylus axei; Large-mouth Stomach Worms (adults) – Habronema muscae; Bots (oral and gastric stages) – Gasterophilus spp. including G. intestinalis and G. nasalis; Lungworms (adults and fourth-stage larvae) – Dictyocaulus arnfieldi; Intestinal Threadworms (adults) – Strongyloides westeri; Summer Sores caused by Habronema and Draschia spp. cutaneous third-stage larvae; Dermatitis caused by neck threadworm microfilariae, Onchocerca sp.

ZIMECTERIN® GOLD(ivermectin 1.55% / praziquantel 7.75%) Paste

IVOMEC Plus Injection is indicated for the effective treatment and control of the following parasites of cattle: Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi (including inhibited O. ostertagi) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis Cooperia oncophora C. punctata C. pectinata Bunostomum phlebotomum Nematodirus helvetianus (adults only) N. spathiger (adults only) Oesophagostomum radiatum Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus Liver Flukes: Fasciola hepatica (adults only) Cattle Grubs (parasitic stages): Hypoderma bovis H. lineatum Sucking Lice: Linognathus vituli Haematopinus eurysternus Solenopotes capillatus Mange Mites (cattle scabIvermectin has been approved as a scabicide by USDA/APHIS. Federal regulations require that cattle infested with or exposed to scabies (i.e., infestations with Psoroptes ovis) be treated. Ivermectin when used according to label instructions meets this requirement. Treated cattle may be shipped interstate, but they must not be mixed with other cattle for 14 days following treatment. The federal regulations make no restriction on the movement of cattle not affected with or exposed to scabies. However, individual states have additional regulations to govern the interstate shipment of cattle and the regulatory veterinarian in the state of destination should be consulted for applicable regulations on the use of ivermectin in the control of scabies.): Psoroptes ovis (syn. P. communis var. bovis) Sarcoptes scabiei var. bovis

Ivomec® Plus (ivermectin and clorsulon) Injection for Cattle

INDICATIONS: Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Ivermectin paste provides effective treatment and control of the following parasites in horses: large strongyles (adults), including Strongylus vulgaris (including early forms in blood vessels), S. edentatus (including tissue stages), S. equinus, Triodontophorus spp. including T. brevicauda and T. serratus, and Craterostomum acuticaudatum; small strongyles (adults, including those resistant to some benzimidazole-class compounds), including Coronocyclus spp. (C. coronatus, C. labratus, and C. labiatus), Cyathostomum spp. (C. catinatum and C. pateratum), Cylicocyclus spp. (C. insignis, C. leptostomum, C. nassatus, and C. brevicapsulatus), Cylicodontophorus spp., Cylicostephanus spp. (C. calicatus, C. goldi, C. longibursatus, and C. minutus), and Poteriostomum spp.; small strongyles (fourth-stage larvae); pinworms (adults and fourth-stage larvae), Oxyuris equi; ascarids (adults and third- and fourth-stage larvae), Parascaris equorum; hairworms (adults), Trichostrongylus axei; large-mouthed stomach worms (adults), Habronema muscae; bots (oral and gastric stages), Gasterophilus spp. including G. intestinalis and G. nasalis; lungworms (adults and fourth-stage larvae), Dictyocaulus arnfieldi; intestinal threadworms (adults), Strongyloides westeri; summer sores caused by Habronema and Draschia spp. (cutaneous third-stage larvae); and dermatitis caused by neck threadworm microfilariae (Onchocerca spp.).

PawBliss Anthelmintic and BoticideIvermectin Horse Paste 1.87

For the effective treatment and control of the following parasites in cattle: Gastrointestinal Roundworms (adults and fourth-stage larve): Ostertagia ostertagi (including inhibited O. ostertagi) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis Cooperia oncophora C. punctata C. pectinata Bunostomum phlebotomum Nematodirus helvetianus (adults only) N. spathiger (adults only) Oesophagostomum radiatum Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparous Liver Flukes: Fasciola hepatica (adults only) Cattle Grubs (parasitic stages): Hypoderma bovis H. lineatum Sucking Lice: Linognathus vituli Haematopinus eurysternus Solenopotes capillatus Manage Mites (Cattle Scab): Psoroptes ovis (syn. P. communis var. bovis) Sarcoptes scabiei var. bovis Persistent Activity Ivermectin and clorsulon injection has been proven to effectively control infections and to protect cattle from reinfection with Dictyocaulus viviparus and Oesophagostomum radiatum for 28 days after treatment; Ostertagia ostertagi, Trichostronglyus axei and Cooperia punctata for 21 days after treatment; Haemonchus placei and Cooperia oncophora for 14 days after treatment.

Animec™ Plus

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. EQUIMAX (ivermectin/praziquantel) Oral Paste is indicated for the treatment and control of the following parasites: Tapeworms Anoplocephala perfoliata Large Strongyles (adults) Strongylus vulgaris (also early forms in blood vessels) S. edentatus (also tissue stages) S. equinus Triodontophorus spp. Small Strongyles (adults, including those resistant to some benzimidazole class compounds) Cyathostomum spp. Cylicocyclus spp. Cylicostephanus spp. Cylicodontophorus spp. Small Strongyles (fourth-stage larvae) Pinworms (adults and fourth-stage larvae) Oxyuris equi Ascarids (adults and third- and fourth-stage larvae) Parascaris equorum Hairworms (adults) Trichostrongylus axei Large-mouth Stomach Worms (adults) Habronema muscae Bots (oral and gastric stages) Gasterophilus spp. Lungworms (adults and fourth-stage larvae) Dictyocaulus arnfieldi Intestinal Threadworms (adults) Strongyloides westeri Summer Sores caused by Habronema and Draschia spp. cutaneous third-stage larvae Dermatitis caused by Neck Threadworm microfilariae, Onchocerca sp.

Equimax®(ivermectin 1.87% / praziquantel 14.03%) Oral Paste Anthelmintic and Boticide

AGRI-MECTIN® Injection has been proved to effectively control infections and to protect cattle from reinfection with Dictyocaulus viviparus and Oesophagostomum radiatum for 28 days after treatment; Ostertagia ostertagi, Trichostrongylus axei and Cooperia punctata for 21 days after treatment; Haemonchus placei and Cooperia oncophora for 14 days after treatment. Swine: AGRI-MECTIN ® Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, lice and mange mites in swine: Gastrointestinal roundworms Large roundworm, Ascaris suum(adults and fourth-stage larvae) Red stomach worm, Hyostrongylus rubidus (adults and fourth-stage larvae) Nodular worm, Oesophagostomum spp. (adults and fourth-stage larvae) Threadworm, Strongyloides ransomi (adults) Somatic Roundworm Larvae: Threadworm, Strongyloides ransomi (somatic larvae) Sows must be treated at least seven days before farrowing to prevent infection in piglets. Lungworm: Metastrongylus spp. (adults) Lice: Haematopinus suis Mange Mites: Sarcoptes scabiei var. suis

AGRI-MECTIN (ivermectin)

PERSISTENT ACTIVITY Ivermectin topical solution has been proved to effectively control infections and to protect cattle from re-infection with: Oesophagostomum radiatum and Dictyocaulus viviparus for 28 days after treatment; Cooperia punctata and Trichostrongylus axei for 21 days after treatment; Ostertagia ostertagi, Haemonchus placei, Cooperia oncophora and Cooperia surnabada for 14 days after treatment; Damalinia bovis for 56 days after treatment. TREATMENT OF CATTLE FOR HORN FLIES VetrimecTM Pour-On (ivermectin topical solution) controls horn flies (Haematobia irritans) for up to 28 days after dosing. For best results VetrimecTM Pour-On (ivermectin topical solution) should be part of a parasite control program for both internal and external parasites based on the epidemiology of these parasites. Consult your veterinarian or an entomologist for the most effective timing of applications.

FDA application 200-318

Cattle: IVERMECTIN Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, grubs, sucking lice and mange mites in cattle: Gastrointestinal Roundworms(adults and fourth-stage larvae): Ostertagia ostertagi (Including inhibitedO. ostertagi) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis Cooperia oncophora C. punctata C. pectinata Oesophagostomum radiatum Bunostomum phlebotomum Nematodirus helvetianus(adults only) N. spathiger (adults only) Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus Cattle Grubs(parasitic stages): Hypoderma bovisH. lineatum Solenopotes capillatus Sucking Lice: Linognathus vituli Haematopinus eurysternus Solenopotes capillatus Mites Iscabies: Psoroptes ovis (Syn.P. communisvar.bovis) Sarcoptes scabiei var. bovis

IVERMECTIN INJECTION for Cattle and Swine 1% Sterile Solution

Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Emergency Use Authorization (EUA) for Ivermectin Liquid for Horses (ivermectin oral solution) for New World Screwworm The U.S. Food and Drug Administration (FDA) has issued an EUA for the emergency use of Ivermectin Liquid for Horses for short-term prevention of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) when administered within 24 hours of birth or at the time of initial wound care in horses. Ivermectin Oral Liquid for Horses is not approved or conditionally approved for this use. It is a violation of Federal law to use this drug product other than as directed in the fact sheet. Scan the QR code or visit the manufacturer's website to access the fact sheet. Read the fact sheet for full product information.

Ivermectin Liquid for Horses

INDICATIONS Ivermax® (ivermectin topical solution) Pour-On applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites. Gastrointestinal Roundworms Ostertagia ostertagi (including inhibited stage) (adults and L4) Haemonchus placei (adults and L4) Trichostrongylus axei (adults and L4) T. colubriformis (adults and L4) Cooperia oncophora (adults and L4) Cooperia punctata (adults and L4) Cooperia surnabada (adults and L4) Strongyloides papillosus (adults) Oesophagostomum radiatum (adults and L4) Trichuris spp. (adults) Lung Worms Dictyocaulus viviparus (adults and L4) Cattle Grubs (parasitic stages) Hypoderma bovis H. lineatum Mites Sarcoptes scabiei var. bovis Lice Linognathus vituli Haematopinus eurysternus Damalinia bovis Solenopotes capillatus Horn Flies Haematobia irritans

FDA application 200-318

Ivermectin Pour-On (ivermectin topical solution) applied at the recommended dose level of 500 mcg/kg is indicated for the effective control of these parasites. Gastrointestinal Roundworms Ostertagia ostertagi (including inhibited stage) (adults and L4) Haemonchus placei (adults and L4) Trichostrongylus axei (adults and L4) T. colubriformis (adults and L4) Cooperia oncophora (adults and L4) Cooperia punctata (adults and L4) Cooperia surnabada (adults and L4) Strongyloides papillosus (adults) Oesophagostomum radiatum (adults and L4) Trichuris spp. Lungworms (adults) Dictyocaulus viviparus (adults and L4) Cattle Grubs Hypoderma bovis H. lineatum (parasitic stages) Mites Sarcoptes scabiei var. bovis Lice Linognathus vituli Haematopinus eurysternus Damalinia bovis Solenopotes capillatus Horn Flies Haematobia irritans

DurvetIVERMECTIN POUR-ON (ivermectin topical solution) for Cattle

Ivermax ® Plus Injection is indicated for the effective treatment and control of the following parasites in cattle: Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi (including inhibited O. ostertagi ) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis Cooperia oncophora C. punctata C. pectinata Bunostomum phlebotomum Nematodirus helvetianus (adults only) N. spathiger (adults only) Oesophagostomum radiatum Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus Liver Flukes: Fasciola hepatica (adults only) Cattle Grubs (parasitic stages): Hypoderma bovis H. lineatum Sucking Lice: Linognathus vituli Haematopinus eurysternus Solenopotes capillatus Mange Mites (cattle scab*): Psoroptes ovis (syn. P. communis var. bovis) Sarcoptes scabiei var. bovis

IVERMAX® PLUS(ivermectin and clorsulon)INJECTION FOR CATTLE

Privermectin® Drench for Sheep provides treatment and control of adult and fourth-stage larvae of the following parasites: Gastrointestinal Roundworms – Haemonchus contortus, Ostertagia circumcincta, Trichostrongylus axei, T. colubriformis, Cooperia curticei, Nematodirus spathiger, N. battus, and Oesophagostomum columbianum; Lungworms – Dictyocaulus filaria; and all the larval stages of Nasal Bot – Oestrus ovis. It also provides treatment and control of adult forms only of the following Gastrointestinal Roundworms – Haemonchus placei, Cooperia oncophora, Strongyloides papillosus, Oesophagostomum venulosum, Trichuris ovis, and Chabertia ovina.

Privermectin® Drench for Sheep(ivermectin)

For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense), and tapeworms (Dipylidium caninum, Taenia pisiformis).

IVERHART MAX® Chew (ivermectin/pyrantel pamoate/praziquantel)

For the Treatment and Control of Worms and Bots of Sheep 20- 100 lb Doses (240 mL) 83- 100 lb Doses (960 mL) See booklet for additional information. Restricted Drug (California) - Use Only as Directed For Animal Use Only • Keep Out of Reach of Children Approved by FDA under ANADA # 200-327 Manufactured For: DURVET, INC. Blue Springs, MO U.S.A. www.durvet.com

Ivermectin Sheep Drench(invermectin)0.08% Solution Parasiticide

INDICATIONS: For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxoscaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancyclostoma braziliense).

HeartArmor Plus (ivermectin / pyrantel)

Ivermectin Pour-On for Cattle (ivermectin topical solution) delivers internal and external parasite control in one convenient low-volume application. Ivermectin Pour-On for Cattle contains ivermectin, a unique chemical entity.

IVERMECTIN(ivermectin topical solution)5 mg ivermectin per mLPOUR-ON for Cattle POUR-ON for Cattle

For the Treatment and Control of Worms and Bots of Sheep 20- 100 lb Doses (100 mL) See booklet for additional information. Restricted Drug (California) - Use Only as Directed For Animal Use Only • Keep Out of Reach of Children

Ivermectin Sheep Drench(invermectin)0.08% Solution Parasiticide

Ivermax® Pour-On for Cattle (ivermectin topical solution) delivers internal and external parasite control in one convenient low-volume application. Ivermax® Pour-On for Cattle contains ivermectin, a unique chemical entity.

Ivermax® Pour-On for Cattle(ivermectin topical solution)

For the effective treatment and control of internal parasites, including adult liver flukes, and external parasites. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

Ivomec® Plus (ivermectin and clorsulon) Injection for Cattle

Vetrimec™ Pour-On for Cattle applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites.

Vetrimec™ Pour-On(ivermectin topical solution) for Cattle

ACTIVE INGREDIENT Ivermectin — 18.7 mg/mL (1.87%)

StrideGuardTM (IVERMECTIN) LIQUID 1.87% Oral Solution

Mode of Action: Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the never or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The margin of safety is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactions have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.

SparMectin-E

OTHER WARNINGS: Parasite resistance may develop to any dewormer, and has been reported for most classes of dewormers. Treatment with a dewormer used in conjunction with parasite management practices appropriate to the geographic area and the animal(s) to be treated may slow the development of parasite resistance. Fecal examinations or other diagnostic tests and parasite management history should be used to determine if the product is appropriate for the herd prior to the use of any dewormer. Following the use of any dewormer, effectiveness of treatment should be monitored (for example, with the use of a fecal egg count reduction test or another appropriate method). A decrease in a drug's effectiveness over time as calculated by fecal egg count reduction tests may indicate the development of resistance to the dewormer administered. Your parasite management plan should be adjusted accordingly based on regular monitoring. Environmental Safety: Ivermectin and excreted ivermectin residues may adversely affect aquatic organisms. Do not contaminate ground or surface water. Dispose of the syringe in an approved landfill or by incineration. INFORMATION FOR HORSE OWNERS: Swelling and itching reactions after treatment with IVERMECTIN (ivermectin paste) have occurred in horses carrying heavy infections of neck threadworm (Onchocerca sp.) microfilariae. These reactions were most likely the result of microfilariae dying in large numbers. Symptomatic treatment may be advisable. Consult your veterinarian should any such reactions occur. Healing of summer sores involving extensive tissue changes may require other appropriate therapy in conjunction with treatment with IVERMECTIN. Reinfection, and measures for its prevention, should also be considered. Consult your veterinarian if the condition does not improve.

FDA application 200-326

WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all drugs out of reach of children. Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance, or to obtain a copy of the SDS contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae. PRECAUTIONS: Ivermax (ivermectin paste) has been formulated specifically for use in horses only. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result. OTHER WARNINGS: Parasite resistance may develop to any dewormer, and has been reported for most classes of dewormers. Treatment with a dewormer used in conjunction with parasite management practices appropriate to the geographic area and the animal(s) to be treated may slow the development of parasite resistance. Fecal examinations or other diagnostic tests and parasite management history should be used to determine if the product is appropriate for the herd prior to the use of any dewormer. Following the use of any dewormer, effectiveness of treatment should be monitored (for example, with the use of a fecal egg count reduction test or another appropriate method). A decrease in a drug's effectiveness over time as calculated by fecal egg count reduction tests may indicate the development of resistance to the dewormer administered. Your parasite management plan should be adjusted accordingly based on regular monitoring.

FDA application 200-326

WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all drugs out of reach of children. Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report adverse reactions in users, to obtain more information, or to obtain a SDS, contact Durvet, Inc. at (800) 821-5570. PRECAUTIONS: DURAMECTIN Paste 1.87% has been formulated specifically for use in horses only. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result. OTHER WARNINGS: Parasite resistance may develop to any dewormer, and has been reported for most classes of dewormers. Treatment with a dewormer used in conjunction with parasite management practices appropriate to the geographic area and the animal(s) to be treated may slow the development of parasite resistance. Fecal examinations or other diagnostic tests and parasite management history should be used to determine if the product is appropriate for the herd, prior to the use of any dewormer. Following the use of any dewormer, effectiveness of treatment should be monitored (for example, with the use of a fecal egg count reduction test or another appropriate method). A decrease in a drug's effectiveness over time as calculated by fecal egg count reduction tests may indicate the development of resistance to the dewormer administered. Your parasite management plan should be adjusted accordingly based on regular monitoring.

DuraMectin (ivermectin) Paste

WARNING NOT FOR USE IN HUMANS. Keep this and all drugs out of the reach of children. The Safety Data Sheets (MSDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Bimeda Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae. WARNING! FLAMMABLE! KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION. This product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention. RESIDUE WARNING: Cattle must not be treated within 48 days of slaughter for human consumption. Because a withdrawal period time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

FDA application 200-318

NOT FOR USE IN HUMANS Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety Information. To report suspected adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Norbrook at 1-866-591-5777. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae. WARNING! FLAMMABLE! KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION. This product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention. RESIDUE WARNING: Cattle must not be treated within 48 days of slaughter for human consumption. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Noromectin® Pour-On(ivermectin topical solution) for Cattle

ANIMAL SAFETY Studies conducted in the U.S.A. have demonstrated the safety margin for ivermectin. Based on plasma levels, the topically applied formulation is expected to be at least as well tolerated by breeding animals as is the subcutaneous formulation which had no effect on breeding performance. WARNING NOT FOR USE IN HUMANS. Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae. WARNING! FLAMMABLE! KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION. This product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention.

FDA application 200-318

Parasite resistance may develop to any dewormer, and has been reported for most classes of dewormers. Treatment with a dewormer used in conjunction with parasite management practices appropriate to the geographic area and the animal(s) to be treated may slow the development of parasite resistance. Fecal examinations or other diagnostic tests and parasite management history should be used to determine if the product is appropriate for the herd/flock, prior to the use of any dewormer. Following the use of any dewormer, effectiveness of treatment should be monitored (for example, with the use of a fecal egg count reduction test or another appropriate method). A decrease in a drug's effectiveness over time as calculated by fecal egg count reduction tests may indicate the development of resistance to the dewormer administered. Your parasite management plan should be adjusted accordingly based on regular monitoring. Keep this and all drugs out of reach of children. Refrain from smoking and eating when handling. Avoid contact with eyes. Immediately wash hands and any spills on the skin with plenty of soap and water following use. Restricted Drug (California) - Use only as directed.

ivomec®(ivermectin)

WARNING NOT FOR USE IN HUMANS. Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae. WARNING! FLAMMABLE! KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION. This product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention.

FDA application 200-318

NOT FOR USE IN HUMANS Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety Information. To report suspected adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Norbrook at 1-866-591-5777. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae. WARNING! FLAMMABLE! KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION. This product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention.

DurvetIVERMECTIN POUR-ON (ivermectin topical solution) for Cattle

OTHER WARNINGS Parasite resisitance may develop to any dewormer, and has been reported for most classes of deowrmers. Treatment with a dewormer used in conjunction with parasite management practices appropriate to the geographic area and the animal(s) to be treated may slow the development of parasite resisitance. Fecal examinations or other diagnostic tests and parasite management history should be used to determine if the product is appropriate for the hear/flock, prior to the use of any dewormer. Following the use of any dewormer, effectiveness of treatment should be monitored (for example, with the use of a fecal egg count reduction test or another appropriate method.) A decrease in a drug's effectiveness over time as calculated by fecal egg count reduction tests may indicate the development of resistance to the dewormer administered. Your parasite manangement plan should be adjusted accordingly based on regular monitoring.

FDA application 200-318

WARNING NOT FOR USE IN HUMANS Keep this and all drugs out of the reach of children. To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Huvepharma, Inc. at 1-877-994-4883 or www.huvepharma.us. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae. WARNING! FLAMMABLE! KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION. This product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention.

ECOMECTIN Cattle Pour-On (ivermectin topical solution)

RESIDUE WARNING: Do not treat reindeer or American bison within 8 weeks (56 days) for slaughter. WARNING NOT FOR USE IN HUMANS. Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance, or to obtain a copy of the SDS, contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae. RESIDUE WARNING: Do not treat cattle within 35 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal. Do not treat swine within 18 days of slaughter.

FDA application 200-447

RESIDUE WARNINGS: Do not treat reindeer or American bison within 8 weeks (56 days) of slaughter. WARNING NOT FOR USE IN HUMANS. Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance, or to obtain a copy of the SDS, call 1-866-591-5777. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae. RESIDUE WARNINGS: Do not treat cattle within 35 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal. Do not treat swine within 18 days of slaughter.

IVERMAX® (ivermectin)Injection for Cattle and Swine1% Sterile Solution

NOT FOR USE IN HUMANS. Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance, or to obtain a copy of the Safety Data Sheet (SDS), contact Boehringer Ingelheim Animal Health USA Inc. at 1-888-637-4251. WARNING! FLAMMABLE! KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION. This product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention.

Ivomec® Pour-On (ivermectin topical solution)

WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all drugs out of reach of children. Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance, or to obtain a copy of the SDS contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae. PRECAUTIONS: IVERMECTIN (ivermectin paste) has been formulated specifically for use in horses only. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result.

FDA application 200-326

NOT FOR USE IN HUMANS. Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance, or to obtain a copy of the SDS, contact Norbrook, Inc at 1-866-591-5777. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1 -888-FDA-VETS or http://www.fda.gov/reportanimalae. RESIDUE WARNINGS: Do not treat cattle within 35 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal. Do not treat swine within 18 days of slaughter.

DurvetIvermectin(ivermectin)

WARNING! NOT FOR USE IN HUMANS Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report adverse effects, obtain an SDS or for assistance, contact First Priority, Inc. at 1-800-650-4899. This product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention. WARNING! FLAMMABLE! KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION.

Vetrimec™ Pour-On(ivermectin topical solution) for Cattle

>RESIDUE WARNING: Do not treat reindeer or American bison within 8 weeks (56 days) of slaughter. < WARNING Not for use in humans. Keep this and all drugs out to reach of children. The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information. To report adverse effects, obtain a MSDS or for assistance, contact Sparhawk Laboratories, Inc. at 1-800-255-6368. RESIDUE WARNING: Do not treat cattle within 35 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product n pre-ruminating calves. Do not use in calves to be processed for veal. Do not treat swine within 18 days of slaughter.

IVERMECTIN INJECTION

WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all drugs out of reach of children. Avoid exercise with care see Safety Data Sheet (SDS) contains more detailed occupational safety information. OTHER WARNINGS: Treatment could result complication with resistance appropriate to the geographic area and the animal(s) to be treated may also receive elimination of parasite resistance. Environmental Safety: Ivermectin can excreted in horse manure and excreted ivermectin residues may adversely affect aquatic organisms. INFORMATION FOR HORSE OWNERS: Swelling and itching reactions after treatment with ivermectin (ivermectin paste) have occurred in horses previously hypersensitive to ivermectin.

Ivermectin Paste 1.87%

RESIDUE WARNING: Do not treat reindeer or American bison within 8 weeks (56 days) of slaughter. WARNING Not for use in humans. Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report adverse effects, obtain a SDS or for assistance, contact Huvepharma, Inc. at 1-877-994-4883. RESIDUE WARNING: Do not treat cattle within 35 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal. Do not treat swine within 18 days of slaughter.

AGRI-MECTIN (ivermectin)

WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all drugs out of reach of children. Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance, or to obtain a copy of the SDS contact Durvalis LLC, at +1-(737)-999-0318. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae.

Durvalis (IVERMECTIN) Paste 1.87%

WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all drugs out of reach of children. Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance, or to obtain a copy of the SDS contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae.

FDA application 200-326

WARNING: NOT FOR USE IN HUMANS. Keep this and all drugs out of reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report adverse effects, obtain an SDS or for assistance, contact Bimeda, Inc. at 1-888-524-6332. RESIDUE WARNING: Do not treat cattle within 21 days of slaughter. Because a withdrawal period in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

FDA application 200-450

For use in dogs only. Keep this and all drugs out of reach of children and pets. In safety studies with ivermectin/pyrantel pamoate/praziquantel tablets, testicular hypoplasia was observed in some dogs receiving 3 and 5 times the maximum recommended dose monthly for 6 months (see Animal Safety). In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.

IVERHART MAX® Chew (ivermectin/pyrantel pamoate/praziquantel)

NOT FOR USE IN HUMANS. Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance, or to obtain a copy of the SDS, contact Boehringer Ingelheim Animal Health USA Inc. at 1-888-637-4251. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS, or at www.fda.gov/reportanimalae.

Ivomec® (ivermectin) Injection for Cattle and Swine

Do not use in horses intended for human consumption. Not for use in humans. Keep this and all drugs out of reach of children. Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report adverse reactions in users, to obtain more information, or to obtain an SDS, contact Boehringer Ingelheim Animal Health USA Inc. at 1-888-637-4251.

ZIMECTERIN® (ivermectin paste) 1.87%

WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all drugs out of reach of children. Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report adverse reactions in users, to obtain more information, or to obtain a SDS, contact Farnam Companies, Inc. at (800) 234-2269.

IverCare Paste

ANIMAL SAFETY: IVERMECTIN (ivermectin paste) may be used in horses of all ages, including mares at any stage of pregnancy. Stallions may be treated without adversely affecting their fertility. WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all drugs out of the reach of children. Refrain from smoking or eating when handling this product. Wash hands after use. Avoid contact with eyes.

Vrettsio Ivermectin Horse Paste 1.87%

User Safety Warnings Not for use in humans. Keep out of reach of children. Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes. To obtain a Safety Data Sheet(s), contact Alberta Veterinary Laboratories Ltd at 1-877-456-2755 or solvet-us.com/products/ivermectin-liquid-for-horses. See Fact Sheet for Animal Safety Warnings and Precautions, Environmental Warnings, and Other Warnings.

Ivermectin Liquid for Horses

Not for use in humans. Keep this and all drugs out of the reach of children. Refrain from eating or smoking when handling. Wash hands after use. Avoid contact with eyes. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report adverse reactions in users, to obtain more information, or to obtain a SDS, contact Bimeda Inc. at 1-888-524-6332.

Equimax®(ivermectin 1.87% / praziquantel 14.03%) Oral Paste Anthelmintic and Boticide

RESIDUE WARNING: Do not treat cattle within 35 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal. Do not treat swine within 18 days of slaughter.

FDA application 200-447

RESIDUE WARNING: Cattle must not be treated within 48 days of slaughter for human consumption. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

FDA application 200-318

• For veterinary use only • Not for human use • Not intended for dogs or cats • Do not exceed recommended dosage • Keep out of reach of children Additional Warnings: Not for use in humans. Keep this and all drugs out of reach of children. Refrain from smoking or eating when handling. Wash hands after use. Avoid contact with eyes.

StrideGuardTM (IVERMECTIN) LIQUID 1.87% Oral Solution

NOT FOR USE IN HUMANS. Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance, or to obtain a copy of the SDS, contact Boehringer Ingelheim Animal Health USA Inc. at 1-888-637-4251.

Ivomec® Plus (ivermectin and clorsulon) Injection for Cattle

WARNINGS Not for use in humans. Keep this and all drugs out of the reach of children. Do not use in horses intended for human consumption. Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes. The Safety Data Sheet (SDS) contains more detailed occupational safety information.

SparMectin-E

WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all drugs out of reach of children. Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes. The Safety Data Sheet (SDS) contains more detailed occupational safety information.

Ivermectin Paste

ANIMAL SAFETY Studies conducted in the U.S.A. have demonstrated the safety margin for ivermectin. Based on plasma levels, the topically applied formulation is expected to be at least as well tolerated by breeding animals as is the subcutaneous formulation which had no effect on breeding performance.

Bimeda, Inc. Bimectin Pour-On for Cattle (ivermectin topical solution) ANADA 200-318, Approved by FDA

Do not treat cattle within 21 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Ivomec® Plus (ivermectin and clorsulon) Injection for Cattle

Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.

VetriShield Plus (ivermectin/pyrantel pamoate) Flavored Chewables

WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all drugs out of the reach of children. Refrain from smoking or eating when handling this product. Wash hands after use. Avoid contact with eyes.

PawBliss Anthelmintic and BoticideIvermectin Horse Paste 1.87

Do not treat sheep within 11 days of slaughter. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report adverse effects in users, to obtain an SDS, or for assistance call 1-888-637-4251.

ivomec®(ivermectin)

ANIMAL SAFETY: Vetrimec Paste (ivermectin paste) may be used in horses of all ages, including mares at any stage of pregnancy. Stallions may be treated without adversely affecting their fertility.

FDA application 200-326

The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report adverse effects in users, to obtain an SDS, or for assistance call 1-800-650-4899.

Privermectin® Drench for Sheep(ivermectin)

Not safe or approved for human use. May be used in horses of all ages including mares at any stage of pregnancy. KEEP OUT OF REACH OF CHILDREN.

Vetr Ivermectin (1.87% ivermectin oral paste)

RESIDUE WARNING: Do not treat reindeer or American bison within 8 weeks (56 days) of slaughter.

FDA application 200-447

Use product on or before its expiration date. Discard or return unused tablets.

VetriShield Plus (ivermectin/pyrantel pamoate) Flavored Chewables

Do not use in horses intended for human consumption.

Equimax®(ivermectin 1.87% / praziquantel 14.03%) Oral Paste Anthelmintic and Boticide

Do not treat sheep within 11 days of slaughter.

Ivermectin Sheep Drench(invermectin)0.08% Solution Parasiticide

ADVERSE REACTIONS: In clinical field trials with ivermectin/pyrantel, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). POST-APPROVAL EXPERIENCE: The following adverse events are based on post-approval adverse drug experience reporting for ivermectin/pyrantel. Not all adverse events are reported to FDA/CVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data. The following adverse events reported in dogs are listed in decreasing order of reporting frequency: vomiting, diarrhea, lethargy, anorexia, seizures, ataxia, muscle tremors, and hypersalivation, pruritus. In some cases, choking or intestinal obstruction has been reported after administration of ivermectin/pyrantel. CONTACT INFORMATION: Contact PET’S CHOICE® at 1-866-462-1702 or PetsChoicePharmaceuticals.com. To report suspected adverse drug experiences, contact PET’S CHOICE at 1-866-462-1702. For additional information about reporting adverse drug experiences for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae. To obtain a Safety Data Sheet(s), contact PET’S CHOICE at 1-866-462-1702 or PetsChoicePharmaceuticals.com.

HeartArmor Plus (ivermectin / pyrantel)

ADVERSE REACTIONS: In clinical field trials with ivermectin/pyrantel, vomiting or diarrhea within 24 hours of dosing was observed (1.1% of administered doses). ​POST-APPROVAL EXPERIENCE:​ The following adverse events are based on post-approval adverse drug experience reporting for ivermectin/pyrantel. Not all adverse events are reported to FDA/CVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data. The following adverse events reported in dogs are listed in decreasing order of reporting frequency: Vomiting, diarrhea, lethargy, anorexia, seizures, ataxia, muscle tremors, hypersalivation, pruritus. In some cases, choking or intestinal obstruction has been reported after administration of ivermectin/pyrantel. Contact Information: Contact Merck Animal Health at 1-800-224-5318 or www.TriHeartPlus.com. To report suspected adverse drug experiences, contact Merck Animal Health at 1-800-224-5318. For additional information about reporting adverse drug experiences for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae To obtain a Safety Data Sheet(s), contact Merck Animal Health at 1-800-224-5318 or www.Tri-HeartPlus.com.

Tri-Heart Plus (Ivermectin and Pyrantel)

In a field study with IVERHART MAX Chew, self-limiting adverse reactions, including vomiting, diarrhea, lethargy, difficulty swallowing, excessive salivation, increased water consumption, and coughing were reported. Self-limiting adverse reactions, including lethargy, limpness, salivation, shaking, diarrhea, decreased appetite, licking lips, and belching were reported between 20 minutes and 72 hours following treatment in a field study with ivermectin/pyrantel pamoate/praziquantel tablets. In field studies with ivermectin/pyrantel/praziquantel pamoate tablets, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported in dogs following the use of ivermectin products: depression/lethargy, vomiting,anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions, and hypersalivation. To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Virbac AH, Inc. at 1-800-338-3659 or us.virbac.com. For additional information about adverse drug experience reporting for animal drugs, contact the FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae.

IVERHART MAX® Chew (ivermectin/pyrantel pamoate/praziquantel)

In clinical field trials with HEARTGARD® PLUS, vomiting or diarrhea within 24 hours of dosing was observed (1.1% of administered doses). Post-Approval Experience (2022): The following adverse events are based on post-approval adverse drug experience reporting for HEARTGARD® PLUS. Not all adverse events are reported to FDA/CVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data. The following adverse events reported in dogs are listed in decreasing order of reporting frequency: Vomiting, diarrhea, lethargy, anorexia, seizures, ataxia, muscle tremors, hypersalivation, pruritus. In some cases, choking or intestinal obstruction has been reported after administration of HEARTGARD® PLUS. Contact Information: To report suspected adverse drug events, for technical assistance, or to obtain a copy of the Safety Data Sheet (SDS), contact Boehringer Ingelheim Animal Health USA Inc. at 1-888-637-4251. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS, or www.fda.gov/reportanimalae.

HEARTGARD® PLUS (ivermectin/pyrantel)

ADVERSE REACTIONS: In clinical trials with ivermectin/pyrantel, vomiting or diarrhea within 24 hours of dosing was observed (1.1% of administered doses). POST-APPROVAL EXPERIENCE (2022): The following adverse events are based on post-approval adverse drug experience reporting for ivermectin/pyrantel. Not all adverse events are reported to FDA/CVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data. The following adverse events reported in dogs are listed in decreasing order of reporting frequency: Vomiting, diarrhea, lethargy, anorexia, seizures, ataxia, muscle tremors, hypersalivation, pruritus. In some cases, choking or intestinal obstruction has been reported after administration of ivermectin/pyrantel. CONTACT INFORMATION: To report suspected adverse drug events, for technical assistance, or to obtain a copy of the Safety Data Sheet (SDS), contact Virbac AH, Inc. at 1-800-338-3659. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS, or www.fda.gov/reportanimalae.

IVERHART PLUS® (ivermectin/pyrantel) Flavored Chewables

In clinical trials with ivermectin/pyrantel, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of ivermectin: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation. To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Virbac AH, Inc at 1-800-338-3659 or us.virbac.com. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae.

VetriShield Plus (ivermectin/pyrantel pamoate) Flavored Chewables

The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report adverse effects in users, to obtain an SDS, or for assistance call 1-800-650-4899.

Ivermectin Sheep Drench(invermectin)0.08% Solution Parasiticide

Give only by subcutaneous injection at a dose volume of 1 mL (10 milligrams of ivermectin and 100 milligrams of clorsulon) per 110 pounds (50 kg) body weight.

Subcutaneous

ivomec® Plus

1 milliliter (10 milligrams of ivermectin and 100 milligrams of clorsulon) per 50 kilograms (110 pounds). For subcutaneous use.

Subcutaneous

For subcutaneous use only. Not for intravenous or intramuscular use. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. Do not use in other animal species because severe adverse reactions, including fatalities in dogs, may result. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Noromectin® Plus

1 mL for each 110 lbs (50 kg) body weight. This volume will deliver 10 mg ivermectin and 100 mg clorsulon.

Subcutaneous

Bimectin® Plus

Administer 1 mL per 110 lb (50 kg) body weight. This delivers 10 mg ivermectin and 100 mg clorsulon.

Subcutaneous

For subcutaneous use only. Not for intravenous or intramuscular use. Do not use in other animal species because severe adverse reactions, including fatalities in dogs, may result.

SparMectin Plus Clorsulon

1 mL per 110 lb (200 micrograms ivermectin per kilogram) body weight subcutaneously .

Subcutaneous

Do not use in calves to be processed for veal. For subcutaneous use only.

Phoenectin®

1 mL for each 22 lb of body weight (500 mcg/kg).

Topical

Do not use on calves to be processed for veal.

Privermectin®

One milliliter per 22 pounds of body weight.

Topical

Do not treat cattle within 48 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product on preruminating calves. Do not use on calves to be processed for veal.

Ivermectin Pour-On for Cattle

23 milligrams per 250 pounds of body weight.

Oral

For oral use only. Do not treat cattle within 24 days of slaughter. Because withdrawal time in milk has not been established, do not use in female dairy of breeding age. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

Ivomec® Cattle Paste 0.153%

Cattle, excluding veal calves

200 micrograms per kilogram of body weight.

Subcutaneous

Do not treat cattle within 35 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Noromectin®

Cattle (Calves, Ruminating)

Administer one bolus per calf weighing at least 275 pounds (125 kilograms) and not more than 660 pound (300 kilograms) on the day of administration.

Oral

The bolus was specifically designed for use in cattle. Do not use in other animal species. Calves must be ruminating and older than 12 weeks of age. Do not administer to calves weighing less than 275 pounds (125 kilograms). Do not administer a damaged bolus. Because a milk withdrawal time has not been established, do not use in female dairy cattle of breeding age. Do not slaughter within 180 days of treatment. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

Ivomec® Sustained-Release Bolus for Cattle

Beef cattle and dairy cattle (except dairy cows)

One milliliter per 22 pounds of body weight.

Topical

Ecomectin

Cattle (excluding veal calves)

200 micrograms ivermectin per kilogram of body weight (1 mL per 50 kg of body weight).

Subcutaneous

Do not use in calves to be processed for veal.

Ivermectin Injection

Administer orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb), and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight, as follows: 6.0 to 12 pounds- one tablet containing 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel 12.1 to 25 pounds- one tablet containing 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel 25.1 to 50 pounds- one tablet containing 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel 50.1 to 100 one tablet containing 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel

Oral

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

IVERHART MAX® Chew

A minimum of 6 micrograms of ivermectin and 5 milligrams of pyrantel (as pamoate salt) per kilogram (2.72 micrograms and 2.27 milligrams per pound) of body weight. up to 25 pounds: 68 micrograms ivermectin and 57 milligrams pyrantel pamoate 26 to 50 pounds: 136 micrograms ivermectin and 114 milligrams pyrantel pamoate 51 to 100 pounds: 272 micrograms ivermectin and 227 milligrams pyrantel pamoate

Oral

Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian.

Tri-Heart Plus Chewable Tablets

6.0 micrograms per kilogram body weight (2.72 micrograms per pound), minimum. up to 25 pounds, 68 micrograms; 26 to 50 pounds 136 micrograms; 51 to 100 pounds, 272 micrograms; over 100 pounds, a combination of the appropriate tablets. The drug is administered at monthly dosing intervals.

Oral

Use once-a-month. Recommended for dogs 6 weeks of age and older. Initial use within 1 month after first exposure to mosquitoes. Final use within 1 month after last exposure to mosquitoes. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Heartgard 30®

6.0 micrograms per kilogram body weight (2.72 micrograms per pound), minimum. up to 25 pounds, 68 micrograms; 26 to 50 pounds 136 micrograms; 51 to 100 pounds, 272 micrograms; 100 pounds, a combination of the appropriate tablets.

Oral

Use once-a-month. Recommended for dogs 6 weeks of age and older. Initial use within 1 month after first exposure to mosquitoes. Final use within 1 month after last exposure to mosquitoes. All dogs should be tested for existing heartworm infection before starting treatment with HEARGARD which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae prior to initiating a program with HEARGARD. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Heartgard® Chewables For Dogs

The recommended minimum dosage is 4.5 milligram per pound (10 milligram per kilogram) of imidacloprid and 36.4 micrograms per pound (80 micrograms per kilogram) of ivermectin, topically once a month.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Advantage® DUO

Administer orally at monthly intervals at the recommended minimum dose level of 100 mg fenbendazole, 6 mcg ivermectin, and 5 mg praziquantel per kg of body weight.

Oral

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Panacur® Plus

Administer a minimum of 6 micrograms of ivermectin and 5 mg of pyrantel per kilogram (2.72 micrograms and 2.27 mg per pound) of body weight monthly.

Oral

Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian.

Iverhart™ Plus Flavored Chewables

Dogs (12.1 - 25 Lbs)

Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight. (One table monthly containing 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel)

Oral

For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

IVERHART MAX®

Dogs (6.0 - 12 Lbs)

Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight. (One tablet monthly containing 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel)

Oral

For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

IVERHART MAX®

Dogs (50.1 - 100 Lbs)

Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight. (One tablet monthly containing 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel)

Oral

For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

IVERHART MAX®

Dogs (25.1 - 50 Lbs)

Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight. (One tablet monthly containing 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel)

Oral

For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

IVERHART MAX®

Administer 136 micrograms ivermectin per pound of body weight (300 micrograms per kilogram) as a single dose on approximately 2 pounds grain or sweet feed.

Oral

Do not use in horses intended for human consumption.

Zimecterin-EZ™

200 microgram per kilogram ivermectin (91 microgram per pound) and 1.5 milligram per kilogram praziquantel (.68 milligram per pound) body weight.

Oral

For oral use in horses only. Do not use in horses intended for human consumption. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result

Equimax®

200 micrograms (mcg) per kilogram (/kg) of body weight as a single dose by stomach tube or as an oral drench.

Oral, Nasogastric

Do not use in horses intended for human consumption. Federal law restricts this drug to us by or on the order of a licensed veterinarian.

Iversol Liquid for Horses

91 mcg ivermectin per pound (200 micrograms per kilogram) of body weight as a single dose.

Nasogastric, Oral

Do not use in horses intended for human consumption. Federal law restricts this drug to us by or on the order of a licensed veterinarian.

Eqvalan® Oral Liquid For Horses

20 milligrams per 100 kilograms (220 pounds) of body weight. For intramuscular use.

Intramuscular

Do not use intravenously. Not for use in horses intended for food. Effects of this drug on pregnant mares have not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Eqvalan® Injection

200 mcg/kg ivermectin (91 mcg/lb) and 2.5 mg/kg praziquantel (1.14 mg/lb).

Oral

Do not use in horses intended for human consumption.

Duocare™

200 micrograms per kilogram (91 micrograms per pound) of body weight.

Oral

For oral use only. Do not use in horses intended for human consumption.

Equell®

200 micrograms per kilogram of body weight as a single dose.

Oral, Nasogastric

Do not use in horses intended for human consumption. Federal law restricts this drug to us by or on the order of a licensed veterinarian.

Primectin™ Equine Oral Liquid

1.8 grams of ivermectin (to provide 0.1 milligram per kilogram of body weight per day) and 100 grams of lincomycin per ton of feed Type C medicated feed.

Oral

Feed as the only feed for 7 consecutive days. Continue by feeding a separate feed containing 100 grams lincomycin/ton to complete the lincomycin treatment. Withdraw 6 days before slaughter. Not to be fed to swine that weigh more than 250 pounds. This product is for use in swine only. This product should not be used for other animal species. Occasionally swine fed lincomycin may within the first two days after the onset of treatment develop diarrhea and/or swelling of the anus. On rare occasions, some pigs may show reddening of the skin and irritable behavior. These conditions have been self-correcting within five to eight days without discontinuing the lincomycin treatment. Do not allow rabbits, hamsters, guinea pigs, horses, or ruminants access to feeds containing lincomycin. Ingestion by these species may result in severe gastrointestinal effects.

IVOMEC® plus LINCOMIX®

300 micrograms ivermectin per kilogram of body weight (1 mL per 33 kg of body weight).

Subcutaneous

Ivermectin Injection

1 mL per 75 lb (300 micrograms ivermectin per kilogram) body weight subcutaneously.

Subcutaneous

For subcutaneous use in the neck only.

Phoenectin®

300 micrograms per kilogram (2.2 pounds) subcutaneously.

Subcutaneous

Do not treat swine within 18 days of slaughter.

Noromectin®

Swine (Growing-Finishing)

1.8 grams of ivermectin per ton. Feed to provide 0.1 milligram per kilogram of body weight per day.

Oral

Feed as the only feed for 7 consecutive days. For use in swine only. Withdraw 5 days before slaughter.

Ivomec® Premix for Swine

Swine (Mature and Breeding)

1.8 to 11.8 grams of ivermectin per ton or 18.2 to 120 grams of ivermectin per ton as a top-dress on the daily feed ration (to provide 0.1 milligram per kilogram of body weight per day.

Oral

Feed as the only feed for 7 consecutive days. For use in swine only. Withdraw 5 days before slaughter. in liquid feed supplements.

Ivomec® Premix for Swine

Weaned, Growing and Finishing Pigs

Ivermectin: 1.8 g/ton Bacitracin methylene disalicylate: 250 g/ton

Oral

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.This product contains IVOMEC brand ivermectin and has been formulated specifically for use in swine only. This product should not be used for other animal species. Do not permit water runoff from swine production sites to directly enter lakes, streams, or ponds. Do not contaminate water by direct application or by the improper disposal of drug containers.

BMD® / Ivomec® Premix for Swine

Pregnant Sows

Ivermectin: 1.8 g/ton Bacitracin methylene disalicylate: 250 g/ton

Oral

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.This product contains IVOMEC brand ivermectin and has been formulated specifically for use in swine only. This product should not be used for other animal species. Do not permit water runoff from swine production sites to directly enter lakes, streams, or ponds. Do not contaminate water by direct application or by the improper disposal of drug containers.

BMD® / Ivomec® Premix for Swine

Reindeer

200 micrograms ivermectin per kilogram of body weight (1 mL per 50 kg of body weight).

Subcutaneous

Ivermectin Injection

Reindeer

200 micrograms per kilogram (10 milligrams per 110 pounds) body weight subcutaneously.

Subcutaneous

For subcutaneous use only. Not for intramuscular use. Do not treat reindeer within 56 days of slaughter. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Bimectin® Injection for Cattle and Swine

Reindeer

1 milliliter per 50 kilograms (110 ponds) body weight subcutaneously.

Subcutaneous

For subcutaneous use only. Not for intramuscular use. Do not treat reindeer within 56 days of slaughter. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Ivomec® .27% Injection Grower And Feeder Pigs

Reindeer

200 micrograms ivermectin per kg body weight subcutaneously.

Subcutaneous

For subcutaneous use only.

Phoenectin®

Reindeer

200 micrograms per kilogram of body weight subcutaneously.

Subcutaneous

For subcutaneous use only. Not for intramuscular use. Do not treat reindeer within 56 days of slaughter.

Noromectin®

200 micrograms per kilogram (10 milligrams per 110 pounds) of body weight subcutaneously.

Subcutaneous

For subcutaneous use. Do not slaughter within 56 days of last treatment.

Noromectin®

200 micrograms ivermectin per kilogram of body weight subcutaneously.

Subcutaneous

For subcutaneous use only.

Phoenectin®

Cats and Kittens (4 Weeks of Age and Older)

Administer the contents of one 0.5-milliliter tube topically into each external ear canal.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Acarexx®

Cats (6 Weeks of Age and Older)

Up to 2.3 kilograms (up to 5 pounds), 55 micrograms; 2.3 - 6.8 kilograms (5 to 15 pounds), 165 micrograms; over 6.8 kilograms (15 pounds), a combination of appropriate chewables (recommended minimum dose of 24 micrograms of ivermectin per kilogram of body weight (10.9 micrograms per pound).

Oral

For use in cats 6 weeks of age and older. Administer once a month. The initial dose must be given within a month after cats first exposure to mosquitoes. The final dose must be given within a month after the cats last exposure to mosquitoes.

Heartgard® for Cats

200 micrograms per kilogram (3 milliliter per 26 pounds) of body weight as a single dose oral drench.

Oral

For use in sheep only. Do not use in other animal species as severe adverse reactions, including fatalities in dogs, may result. Do not treat sheep within 11 days of slaughter.

Privermectin™ Drench for Sheep

200 micrograms per kilogram body weight subcutaneously. Repeat in 3 weeks.

Subcutaneous

For subcutaneous use only. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

Ivomec® .27% Injection Grower And Feeder Pigs

200 micrograms ivermectin per kilogram of body weight (1 mL per 50 kg of body weight).

Subcutaneous

Ivermectin Injection

DOSAGE Cattle: Ivermectin Injection should be given only by subcutaneous injection under the loose skin in front of or behind the shoulder at the recommended dose level of 200 mcg of ivermectin per kilogram of body weight. Each mL of Ivermectin contains 10 mg of ivermectin, sufficient to treat 110 lb (50 kg) of body weight (maximum 10 mL per injection site). Body Weight (lb) Dose Volume (mL) 220 2 330 3 440 4 550 5 660 6 770 7 880 8 990 9 1100 10 Swine: Ivermectin Injection should be given only by subcutaneous injection in the neck of swine at the recommended dose level of 300 mcg of ivermectin per kilogram (2.2 lb) of body weight. Each mL of Ivermectin contains 10 mg of ivermectin, sufficient to treat 75 lb of body weight. Body Weight (lb) Dose Volume (mL) Growing Pigs 19 1/4 38 1/2 75 1 150 2 Breeding Animals 225 3 (Sow, Gilts, and 300 4 Boars) 375 5 450 6 Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. ADMINISTRATION Cattle: Ivermectin Injection is to be given subcutaneously only, to reduce risk of potentially fatal clostridial infection of the injection site. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16-gauge, 1/2 to 3/4" needle is suggested. Inject under the loose skin in front of or behind the shoulder (see illustration). When using the 50 mL, 250 mL, 500 mL or 1000 mL package size, use only automatic syringe equipment. Use sterile equipment and sanitize the injection site by applying a suitable disinfectant. Clean, properly disinfected needles should be used to reduce the potential for injection site infections. No special handling or protective clothing is necessary. Swine: Ivermectin (ivermectin) Injection is to be given subcutaneously in the neck. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16- or 18- gauge needle is suggested for sows and boars, while an 18- or 20- gauge needle may be appropriate for young animals. Inject under the skin, immediately behind the ear (see illustration). When using the 50 mL, 250 mL, 500 mL or 1000 mL package size, use only automatic syringe equipment. As with any injection, sterile equipment should be used. The injection site should be cleaned and disinfected with alcohol before injection. The rubber stopper should also be disinfected with alcohol to prevent contamination of the contents. Mild and transient pain reactions may be seen in some swine following subcutaneous administration. Recommended Treatment Program Swine: At the time of initiating any parasite control program, it is important to treat all breeding animals in the herd. After the initial treatment, use Ivermectin (ivermectin) Injection regularly as follows: BREEDING ANIMALS Sows: Treat prior to farrowing, preferably 7-14 days before, to minimize infection of piglets. Gilts: Treat 7-14 days prior to breeding. Treat 7-14 days prior to farrowing. Boars: Frequency and need for treatments are dependent upon exposure. Treat at least two times a year. FEEDER PIGS (Weaners/Growers/Finishers) All weaner/feeder pigs should be treated before placement in clean quarters. Pigs exposed to contaminated soil or pasture may need retreatment if reinfection occurs. NOTE: (1) Ivermectin Injection has a persistent drug level sufficient to control mite infestations throughout the egg to adult life cycle. However, since the ivermectin effect is not immediate, care must be taken to prevent reinfestation from exposure to untreated animals or contaminated facilities. Generally, pigs should not be moved to clean quarters or exposed to uninfested pigs for approximately one week after treatment. Sows should be treated at least one week before farrowing to minimize transfer of mites to newborn baby pigs. (2) Louse eggs are unaffected by Ivermectin Injection and may require up to three weeks to hatch. Louse infestations developing from hatching eggs may require retreatment. (3) Consult a veterinarian for aid in the diagnosis and control of internal and external parasites of swine. Special Minor Use Reindeer: For the treatment and control of warbles (Oedemagena tarandi) in reindeer, inject 200 micrograms ivermectin per kilogram of body weight, subcutaneously. Follow use directions for cattle as described under ADMINISTRATION. American Bison: For the treatment and control of grubs (Hypoderma bovis) in American bison, inject 200 micrograms ivermectin per kilogram of body weight, subcutaneously. Follow use directions for cattle as described under ADMINISTRATION.

SUBCUTANEOUS

FDA application 200-447

DOSAGE: Cattle: Ivermax® Injection should be given only by subcutaneous injection under the loose skin in front of or behind the shoulder at the recommended dose level of 200 mcg of ivermectin per kilogram of body weight. Each mL of Ivermax® contains 10 mg of ivermectin, sufficient to treat 110 lb (50 kg) of body weight (maximum 10 mL per injection site). Body Weight (lb) Dose Volume (mL) 220 2 330 3 440 4 550 5 660 6 770 7 880 8 990 9 1100 10 Swine: Ivermax® Injection should be given only by subcutaneous injection in the neck of swine at the recommended dose level of 300 mcg of ivermectin per kilogram (2.2 lb) of body weight. Each mL of Ivermax® contains 10 mg of ivermectin, sufficient to treat 75 lb of body weight. Body Weight (lb) Dose Volume (mL) Growing Pigs 19 1/4 38 1/2 75 1 150 2 Breeding Animals (Sows,Gilts, and Boars) 225 3 300 4 375 5 450 6 Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. ADMINISTRATION Cattle: Ivermax® Injection is to be given subcutaneously only, to reduce risk of potentially fatal clostridial infection of the injection site. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16-gauge, 1/2 to 3/4" needle is suggested. Inject under the loose skin in front of or behind the shoulder (see illustration). When using the 50 mL, 250 mL, 500 mL or 1000 mL package size, use only automatic syringe equipment. Use sterile equipment and sanitize the injection site by applying a suitable disinfectant. Clean, properly disinfected needles should be used to reduce the potential for injection site infections. No special handling or protective clothing is necessary. Swine: Ivermax® (ivermectin) Injection is to be given subcutaneously in the neck. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16- or 18- gauge needle is suggested for sows and boars, while an 18- or 20- gauge needle may be appropriate for young animals. Inject under the skin, immediately behind the ear (see illustration). When using the 50 mL, 250 mL, 500 mL or 1000 mL package size, use only automatic syringe equipment. As with any injection, sterile equipment should be used. The injection site should be cleaned and disinfected with alcohol before injection. The rubber stopper should also be disinfected with alcohol to prevent contamination of the contents. Mild and transient pain reactions may be seen in some swine following subcutaneous administration. Recommended Treatment Program Swine: At the time of initiating any parasite control program, it is important to treat all breeding animals in the herd. After the initial treatment, use Ivermax® (ivermectin) Injection regularly as follows: BREEDING ANIMALS Sows: Treat prior to farrowing, preferably 7-14 days before, to minimize infection of piglets. Gilts: Treat 7-14 days prior to breeding. Treat 7-14 days prior to farrowing. Boars: Frequency and need for treatments are dependent upon exposure. Treat at least two times a year. FEEDER PIGS (Weaners/Growers/Finishers) All weaner/feeder pigs should be treated before placement in clean quarters. Pigs exposed to contaminated soil or pasture may need retreatment if reinfection occurs. NOTE: (1) Ivermax® Injection has a persistent drug level sufficient to control mite infestations throughout the egg to adult life cycle. However, since the ivermectin effect is not immediate, care must be taken to prevent reinfestation from exposure to untreated animals or contaminated facilities. Generally, pigs should not be moved to clean quarters or exposed to uninfested pigs for approximately one week after treatment. Sows should be treated at least one week before farrowing to minimize transfer of mites to newborn baby pigs. (2) Louse eggs are unaffected by Ivermax® Injection and may require up to three weeks to hatch. Louse infestations developing from hatching eggs may require retreatment. (3) Consult a veterinarian for aid in the diagnosis and control of internal and external parasites of swine. Special Minor Use Reindeer: For the treatment and control of warbles (Oedemagena tarandi) in reindeer, inject 200 micrograms ivermectin per kilogram of body weight, subcutaneously. Follow use directions for cattle as described under ADMINISTRATION. American Bison: For the treatment and control of grubs (Hypoderma bovis) in American bison, inject 200 micrograms ivermectin per kilogram of body weight, subcutaneously. Follow use directions for cattle as described under ADMINISTRATION.

SUBCUTANEOUS

FDA application 200-447

PERSISTENT ACTIVITY Ivermectin topical solution has been proved to effectively control infections and to protect cattle from re-infection with: Oesophagostomum radiatum and Dictyocaulus viviparus for 28 days after treatment; Cooperia punctata and Trichostrongylus axei for 21 days after treatment; Ostertagia ostertagi, Haemonchus placei, Cooperia oncophora and Cooperia surnabada for 14 days after treatment; Damalinia bovis for 56 days after treatment. TREATMENT OF CATTLE FOR HORN FLIES Ivermax® (ivermectin topical solution) Pour-On controls horn flies (Haematobia irritans) for up to 28 days after dosing. For best results Ivermax® (ivermectin topical solution) Pour-On should be part of a parasite control program for both internal and external parasites based on the epidemiology of these parasites. Consult your veterinarian or an entomologist for the most effective timing of applications. DOSAGE The dose rate is 1 mL for each 22 lb of body weight. The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. ADMINISTRATION Measure-Squeeze-Pour System (33.8 fl oz 1/Liter Bottle with 25 mL Measuring Cap) This pack contains 1 measuring cap and 1 dip tube. Insert the dip tube into the base of the measuring cap. Leave the “slotted end” of the dip tube exposed in the bottom of the container. Unscrew shipping cap from container top. Screw measuring cap onto container top. Measure: To select the correct dose rate, rotate the adjuster cap (top) in either direction to position the dose indicator to the weight of the animal you want to treat. When body weight is between markings, use the higher setting. Squeeze the container gently to fill the measuring cap to the required dose. Release your grip and any excess will return to the container. Pour: Apply the full dose by tipping and pouring along the backline of the animal until the measuring cap is empty. Storage:The measuring cap should not remain attached to the container when not in use. Detach the measuring cap after each use and replace the shipping cap to close the container top. BackPack (84.5 fl oz/2.5 Liter Pack and 169 fl oz/5 Liter Pack) Connect the applicator gun to the backpack as follows: Attach the open end of the draw-off tubing to the dosing equipment. (Because of the solvents used in the formulation, only the Protector Drench Gun from Instrument Supplies Limited, or equivalent, is recommended. Other applicators may exhibit compatibility problems resulting in locking, incorrect dosage or leakage). Replace the shipping cap with the draw-off cap and tighten down. Attach draw-off tubing to the draw-off cap. Gently prime the applicator gun, checking for leaks. Follow the manufacturer's directions for adjusting the dose. When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container. To prevent removal of special lubricants from the Protector Drench Gun, the gun and tubing must not be washed. Free standing bottle (338 fl oz/10 Liter Bottle and 676 fl oz/20 Liter Bottle) Use dosing equipment (applicator, draw-off tubing, cap with stem) compatible with Ivermax® (ivermectin topical solution) Pour-On. Other dosing equipment may be incompatible, resulting in locking, incorrect dosage and leakage. Follow the dosing equipment manufacturer's directions for adjusting the dose and maintenance of the dosing equipment. Connect the dosing applicator and the draw-off tubing to the bottle as follows: Attach the open end of the draw-off tubing to an appropriate dosing applicator. Attach draw-off tubing to the cap with the stem. Replace the shipping cap with the cap having the draw-off tubing. Gently prime the applicator gun, checking for leaks. When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun, draw-off tubing and cap with stem from the product container and empty the product from the gun and the tubing back into the product container and replace the shipping cap.

TOPICAL

FDA application 200-318

Any single-dose syringe or standard automatic syringe equipment may be used with the 50 mL bottle. Use the 50 mL bottle within 6 months of first puncture and puncture a maximum of 12 times. If more than 12 punctures are anticipated, the use of multi-dosing equipment is recommended. When using a draw-off spike or needle with bore diameter larger than 16-gauge, discard any product remaining in the bottle immediately after use. When using the 200 mL, 500 mL or 1000 mL pack size, use only automatic syringe equipment. Discard any product remaining in the pack immediately after use. Use sterile equipment and sanitize the injection site by applying a suitable disinfectant. Clean, properly disinfected needles should be used to reduce the potential for injection site infections. The rubber stopper should also be disinfected with alcohol to prevent contamination of the contents. No special handling or protective clothing is necessary. Cattle: IVOMEC (ivermectin) Injection is to be given subcutaneously only, to reduce risk of potentially fatal clostridial infection of the injection site. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16-gauge, 1/2 to 3/4" needle is suggested. Inject under the loose skin in front of or behind the shoulder (see illustration). Swine: IVOMEC Injection is to be given subcutaneously in the neck. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16- or 18-gauge needle is suggested for sows and boars, while an 18- or 20-gauge needle may be appropriate for young animals. Inject under the skin, immediately behind the ear (see illustration). Mild and transient pain reactions may be seen in some swine following subcutaneous administration. Recommended Treatment Program Swine: At the time of initiating any parasite control program, it is important to treat all breeding animals in the herd. After the initial treatment, use IVOMEC Injection regularly as follows: BREEDING ANIMALS Sows: Treat prior to farrowing, preferably 7–14 days before, to minimize infection of piglets. Gilts: Treat 7–14 days prior to breeding. Treat 7–14 days prior to farrowing. Boars: Frequency and need for treatments are dependent upon exposure. Treat at least two times a year. FEEDER PIGS (Weaners/Growers/Finishers) All weaner/feeder pigs should be treated before placement in clean quarters. Pigs exposed to contaminated soil or pasture may need retreatment if reinfection occurs. NOTE: (1)IVOMEC Injection has a persistent drug level sufficient to control mite infestations throughout the egg to adult life cycle. However, since the ivermectin effect is not immediate, care must be taken to prevent reinfestation from exposure to untreated animals or contaminated facilities. Generally, pigs should not be moved to clean quarters or exposed to uninfested pigs for approximately one week after treatment. Sows should be treated at least one week before farrowing to minimize transfer of mites to newborn baby pigs. (2)Louse eggs are unaffected by IVOMEC Injection and may require up to three weeks to hatch. Louse infestations developing from hatching eggs may require retreatment. (3)Consult a veterinarian for aid in the diagnosis and control of internal and external parasites of swine. Special Minor Use Reindeer: For the treatment and control of warbles (Oedemagena tarandi) in reindeer, inject 200 micrograms ivermectin per kilogram of body weight, subcutaneously. Follow use directions for cattle as described under ADMINISTRATION. American Bison: For the treatment and control of grubs (Hypoderma bovis) in American bison, inject 200 micrograms ivermectin per kilogram of body weight, subcutaneously. Follow use directions for cattle as described under ADMINISTRATION.

SUBCUTANEOUS

Ivomec® (ivermectin) Injection for Cattle and Swine

DOSAGE The dose rate is 1 mL for each 22 lb of body weight. The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. ADMINISTRATION Measure-Squeeze-Pour System (33.8 fl oz 1/Liter Bottle with 25 mL Measuring Cap) This pack contains 1 measuring cap and 1 dip tube. Insert the dip tube into the base of the measuring cap. Leave the “slotted end” of the dip tube exposed in the bottom of the container. Unscrew shipping cap from container top. Screw measuring cap onto container top. Measure: To select the correct dose rate, rotate the adjuster cap (top) in either direction to position the dose indicator to the weight of the animal you want to treat. When body weight is between markings, use the higher setting. Squeeze the container gently to fill the measuring cap to the required dose. Release your grip and any excess will return to the container. Pour: Apply the full dose by tipping and pouring along the backline of the animal until the measuring cap is empty. Storage:The measuring cap should not remain attached to the container when not in use. Detach the measuring cap after each use and replace the shipping cap to close the container top. BackPack (84.5 fl oz/2.5 Liter Pack and 169 fl oz/5 Liter Pack) Connect the applicator gun to the backpack as follows: Attach the open end of the draw-off tubing to the dosing equipment. (Because of the solvents used in the formulation, only the Protector Drench Gun from Instrument Supplies Limited, or equivalent, is recommended. Other applicators may exhibit compatibility problems resulting in locking, incorrect dosage or leakage). Replace the shipping cap with the draw-off cap and tighten down. Attach draw-off tubing to the draw-off cap. Gently prime the applicator gun, checking for leaks. Follow the manufacturer's directions for adjusting the dose. When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container. To prevent removal of special lubricants from the Protector Drench Gun, the gun and tubing must not be washed. Free standing bottle (338 fl oz/10 Liter Bottle and 676 fl oz/20 Liter Bottle) Use dosing equipment (applicator, draw-off tubing, cap with stem) compatible with VetrimecTM Pour-On (ivermectin topical solution). Other dosing equipment may be incompatible, resulting in locking, incorrect dosage and leakage. Follow the dosing equipment manufacturer's directions for adjusting the dose and maintenance of the dosing equipment. Connect the dosing applicator and the draw-off tubing to the bottle as follows: Attach the open end of the draw-off tubing to an appropriate dosing applicator. Attach draw-off tubing to the cap with the stem. Replace the shipping cap with the cap having the draw-off tubing. Gently prime the applicator gun, checking for leaks. When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun, draw-off tubing and cap with stem from the product container and empty the product from the gun and the tubing back into the product container and replace the shipping cap.

TOPICAL

FDA application 200-318

DOSAGE: IVERHART PLUS® (ivermectin/pyrantel) Flavored Chewables should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of roundworms and hookworms is as follows: Dog Weight Flavored Chewable Per Month Ivermectin Content Pyrantel Content Color Coding on Carton 0-25 lbs 1 68 mcg 57 mg Blue 26-50 lbs 1 136 mcg 114 mg Green 51-100 lbs 1 272 mcg 227 mg Brown IVERHART PLUS Flavored Chewables are recommended for dogs 6 weeks of age and older. For dogs over 100 lbs use the appropriate combination of these flavored chewables. ADMINISTRATION: Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find IVERHART PLUS Flavored Chewables palatable, the product can be ordered to the dog by hand. To avoid the risk of choking or intestinal obstruction, the chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing (see PRECAUTIONS and POST-APPROVAL EXPERIENCE). Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Alternatively, it may be added intact to a small amount of dog food to encourage chewing, but care should be taken to ensure that the dog consumes the complete dose at one time. Treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended. IVERHART PLUS Flavored Chewables should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dogs first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dogs last exposure to mosquitoes. When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of IVERHART PLUS Flavored Chewables must be given within a month (30 days) of the last dose of the former medication. If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the flavored chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with IVERHART PLUS Flavored Chewables and resumption of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms. Monthly treatment with IVERHART PLUS Flavored Chewables also provides effective treatment and control of roundworms (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

oral

IVERHART PLUS® (ivermectin/pyrantel) Flavored Chewables

Metering Cup with Measure-Squeeze-Pour System (250 mL Container with 25 mL Metering Cup and 1 Liter Container with 60 mL Metering Cup) This pack contains 1 Metering Cup and 1 dip tube 1.Insert the dip tube into base of the Metering Cup. Leave the "slotted end" of the dip tube exposed in the bottom of the container. 2.Unscrew shipping cap from container top. 3.Screw the Metering Cup onto container top. 4. Measure: To select the correct dose rate, rotate the adjuster cap (top) in either direction to position the dose indicator to the weight of the animal you want to treat. When body weight is between markings, use the higher setting. 5. Squeeze the container gently to fill the Metering Cup to the required dose. Release your grip and any excess will return to the container. 6. Pour: Apply the full dose by tipping and pouring along the backline of the animal until the Metering Cup is empty. 7. Storage: The Metering Cup should not remain attached to the container when not in use. Detach the Metering Cup after each use and replace the shipping cap to close the container top. Collapsible Pack (2.5 L Pack and 5 L Pack) Connect the applicator gun to the collapsible pack as follows: •Attach the open end of the draw-off tubing to the dosing equipment. (Because of the solvents used in the formulation, only the Protector Drench Gun from Instrument Supplies Limited, or equivalent, is recommended. Other applicators may exhibit compatibility problems resulting in locking, incorrect dosage or leakage.) •Replace the shipping cap with the draw-off cap and tighten down. Attach draw-off tubing to the draw-off cap. •Gently prime the applicator gun, checking for leaks. •Follow the manufacturer's directions for adjusting the dose. •When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container. To prevent removal of special lubricants from the Protector Drench Gun, the gun and tubing must not be washed. 20 Liter Pack Use dosing equipment (applicator, draw-off tubing, cap with stem) compatible with IVOMEC Pour-On (ivermectin topical solution). Other dosing equipment may be incompatible, resulting in locking, incorrect dosage and leakage. Follow the dosing equipment manufacturer's directions for adjusting the dose and proper use and maintenance of the dosing equipment. Connect the dosing applicator and the draw-off tubing to the container as follows: •Attach the open end of the draw-off tubing to an appropriate dosing applicator. Attach draw-off tubing to the cap with the stem. Replace the shipping cap with the cap having the draw-off tubing. Gently prime the dosing applicator, checking for leaks. •When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun, draw-off tubing and cap with stem from the product container, empty the product from the gun and tubing back into the product container and replace the shipping cap.

TOPICAL

Ivomec® Pour-On (ivermectin topical solution)

DOSAGE: Tri-Heart® Plus should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of roundworms and hookworms is as follows: Dog Weight Chewable Tablets per Month Ivermectin Content Pyrantel Content Color Coding on Blister Card and Carton Up to 25 lbs. 1 68 mcg 57 mg Blue 26 to 50 lbs. 1 136 mcg 114 mg Green 51 to 100 lbs. 1 272 mcg 227 mg Brown Tri-Heart® Plus is recommended for dogs 6 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these tablets. ADMINISTRATION: Remove only one chewable tablet at a time from the blister card. Because most dogs find Tri-Heart® Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dry food or placed in the back of the dog’s mouth for forced swallowing. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended. Tri-Heart® Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes. When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Tri-Heart® Plus must be given within a month (30 days) of the last dose of the former medication. If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable tablet must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with Tri-Heart® Plus and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms. Monthly treatment with Tri-Heart® Plus also provides effective treatment and control of roundworms (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

ORAL

Tri-Heart Plus (Ivermectin and Pyrantel)

DOSAGE SparMectin-E Liquid for Horses is formulated for administration by stomach tube (nasogastric intubation) or as an oral drench. The recommended dose is 91 mcg of ivermectin per lb (200 mcg/kg) of body weight. Each mL contains sufficient ivermectin to treat 110 lb (50 kg) of body weight: 10 mL will treat an 1100 lb (500 Kg) horse. ADMINISTRATION Use a calibrated dosing syringe inserted into the bottle of measure the appropriate dose, or pour the SparMectin-E Liquid into a graduated cylinder for dose measurement. Use a clean syringe if accessing the bottle to avoid contaminating the remaining product. Special consideration should be given to effects of potential for injury from handling, restraint, and placement of the stomach tube during administration of SparMectin-E Liquid. SparMectin-E Liquid should be administered by drench if the risks associated with tubing are of concern. Due to the potential consequences of improper administration, SparMectin-E Liquid is intended for use by a veterinarian only and is not recommended for dispensing. SparMectin-E Liquid in 1 to 20 and 1 to 40 dilutions with tap water has been shown to be stable for 72 hours under the conditions recommended for the product (i.e., at room temperature, in a tightly closed container, protected from light). The diluted product does not promote the growth of common organisms. However, prolonged storage of the diluted product cannot be recommended, as the effects of possible contaminations and interactions with untested materials are unknown. Administration by stomach tube (gravity or positive flow): The recommended dose can be used undiluted or diluted up to 40 times with clean tepid water. Use tepid water to flush any drug remaining in the tube into the horse's stomach. Administration by drench: For administration of SparMectin-E by drench, an undiluted dose is recommended. Clear the horse's mouth of any food material, elevate the horse's head, and using a syringe, deposit the appropriated dose in the back of the mouth. In order to avoid unnecessary coughing or the potential for material to enter the trachea and lungs, do not use excessive pressure (squirting), do not use a large (diluted) dose volume, and do not deposit the dose in the laryngeal area. Increased dose rejection may occur if the dose is deposited in the buccal space. Keep horse's head elevated and observe the horse to insure the dose is retained.

ORAL

SparMectin-E

IVERHART MAX Chew should be administered orally at monthly intervals and the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/ lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb), and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight, as follows: Dosing Schedule Dog Weight Pounds Chew per Month Chew Size Ivermectin Content Pyrantel Pamoate Content Praziquantel Content 6.0 to 12 1 Toy 34 mcg 28.5 mg 28.5 mg 12.1 to 25 1 Small 68 mcg 57 mg 57 mg 25.1 to 50 1 Medium 136 mcg 114 mg 114 mg 50.1 to 100 1 Large 272 mcg 228 mg 228 mg IVERHART MAX Chew is recommended for dogs 8 weeks of age or older. For dogs over 100 lbs, use the appropriate combination of these chews. Remove only one dose at a time from the packaging. Return the remaining chew(s) to their box to protect from light. The chew can be offered to the dog by hand or added, intact, to a small amount of dog food. Care should be taken to ensure that the dog consumes the complete dose. The treated dog should be observed for a few minutes after administration to confirm that none of the dose has been lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended. IVERHART MAX Chew should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes. When replacing another heartworm preventative product in a heartworm disease prevention program, the first dose of IVERHART MAX Chew must be given within a month (30 days) after the last dose of the former medication. A heartworm test should be performed prior to and 6 months after switching heartworm preventative products. If the interval between doses exceeds a month (30 days), the effectiveness of ivermectin can be reduced. Therefore, for optimal performance, the chew must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with IVERHART MAX Chew and resumption of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms.

ORAL

IVERHART MAX® Chew (ivermectin/pyrantel pamoate/praziquantel)

Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find VetriShield Plus™ Flavored Chewables palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended. VetriShield Plus™ Flavored Chewables should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes. When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of VetriShield Plus™ Flavored Chewables must be given within a month (30 days) of the last dose of the former medication. If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the flavored chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with VetriShield Plus™ Flavored Chewables and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms. Monthly treatment with VetriShield Plus™ Flavored Chewables also provides effective treatment and control of roundworms (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

oral

VetriShield Plus (ivermectin/pyrantel pamoate) Flavored Chewables

DOSAGE: Ivermectin Paste Net Wt: 0.21 oz (6.08 g) This syringe contains sufficient paste to treat one 1250 lb horse at the recommended dose rate of 91 mcg ivermectin per lb (200 mcg/kg) body weight. Each weight marking on the syringe plunger delivers enough paste to treat 250 lb body weight. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. ADMINISTRATION: (1) While holding plunger, turn the knurled ring on the plunger to the right to move it up towards the barrel until the side nearest the barrel aligns with the line at the prescribed weight marking, as shown in the pictogram. (2) Ensure the ring is secured at the appropriate weight by turning the ring 1/4 turn to the left. (3) Make sure that the horse's mouth contains no feed. (4) Remove the cover from the tip of the syringe. (5) Insert the syringe tip into the horse's mouth at the space between the teeth. (6) Depress the plunger as far as it will go, depositing paste on the back of the tongue. (7) Immediately raise the horse's head for a few seconds after dosing. PARASITE CONTROL PROGRAM : All horses should be included in a regular parasite control program with particular attention being paid to mares, foals and yearlings. Foals should be treated initially at 6 to 8 weeks of age, and routine treatment repeated as appropriate. Consult your veterinarian for a control program to meet your specific needs. Ivermectin Paste 1.87% effectively controls gastrointestinal nematodes and bots of horses. Regular treatment will reduce the chances of verminous arteritis caused by Strongylus vulgaris . PRODUCT ADVANTAGES: Broad-spectrum Control– Ivermectin Paste 1.87% kills important internal parasites, including bots and the arterial stages of S. vulgaris, with a single dose. Ivermectin Paste 1.87% is a potent antiparasitic agent that is neither a benzimidazole nor an organophosphate. ANIMAL SAFETY: Ivermectin Paste 1.87% may be used in horses of all ages, including mares at any stage of pregnancy. Stallions may be treated without adversely affecting their fertility.

ORAL

IverCare Paste

DOSAGE The dose rate is 1 mL for each 22 lb of body weight. The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead. ADMINISTRATION Measure-Squeeze-Pour System (33.8 fl oz/1 Liter Bottle with 25 mL Measuring Cap) 1. Insert the dip tube into the base if the measuring cap. Leave the "slotted end' of the dip tube exposed in the bottom of the container. 2. Unscrew shipping cap from container top. 3. Screw measuring cap onto container top. 4. Measure: To select the correct dose rate, rotate the adjuster cap (top) in either direction to position the dose indicator to the weight of the animal you want to treat. When the body weight is between markings, use the higher setting. 5. Squeeze the container gently to fill the measuring cap to the required dose. Relese your grip and any excess will return to the container. 6. Pour: Apply the full dose by tipping and pouring along the backline of the animal until the measuring cap is empty. 7. Storage: The measuring cap should not remain attached tot eh container when not in use. Detach the measuring cap after each use and replace the shipping cap to close the container top. BackPack (84.5 fl oz/2.5 Liter Pack and 169 fl. oz/5 Liter Pack) Connect the applicator gun to the backpack as follows: Attach the open end of the draw-off tubing to the dosing equipment. (Because of the solvents used in the formulation, only the Protector Drench Gun from Instrument Supplies Limited, or equivalent, is recommended. Other applicators may exhibit compatibility problems resulting in locking, incorrect dosage or leakage). Replace the shipping cap with the draw-off cap and tighten down. Attach draw-off tubing to the draw-off cap. Gently prime the applicator gun, checking for leaks. Follow the manufacturer's directions for adjusting the dose. When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container. To prevent removal of special lubricants from the Protector Drench Gun, the gun and tubing must not be washed.

TOPICAL

FDA application 200-318

Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find HEARTGARD® PLUS palatable, the product can be offered to the dog by hand. To avoid the risk of choking or intestinal obstruction, the chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing (see Precautions and Post-Approval Experience). Alternatively, it may be added intact to a small amount of dog food to encourage chewing, but care should be taken to ensure that the dog consumes the complete dose at one time. Treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended. HEARTGARD® PLUS should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes. When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of HEARTGARD® PLUS must be given within a month (30 days) of the last dose of the former medication. If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD® PLUS and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms. Monthly treatment with HEARTGARD® PLUS also provides effective treatment and control of roundworms (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

ORAL

HEARTGARD® PLUS (ivermectin/pyrantel)

Metering Cup with Measure-Squeeze-Pour System (1 Liter (33.8 fl oz) Container with 25 mL Metering Cup) This pack contains 1 Metering Cup and 1 dip tube Insert the dip tube into base of the Metering Cup. Leave the “slotted end” of the dip tube exposed in the bottom of the container. Unscrew shipping cap from container top. Screw the Metering Cup onto container top Measure: To select the correct dose rate, rotate the adjuster cap (top) in either direction to position the dose indicator to the weight of the animal you want to treat. When body weight is between markings, use the higher setting. Squeeze the container gently to fill the Metering Cup to the required dose. Release your grip and any excess will return to the container. Pour: Apply the full dose by tipping and pouring along the backline of the animal until the Metering Cup is empty. Storage: The Metering Cup should not remain attached to the container when not in use. Detach the Metering Cup after each use and replace the shipping cap to close the container top. Collapsible Pack (84.5 fl oz/2.5 L Pack and 169 fl oz/5 L Pack) Connect the applicator gun to the collapsible pack as follows: Attach the open end of the draw-off tubing to the dosing equipment. (Because of the solvents used in the formulation, only the Simcro Tech gun, or equivalent, is recommended. Other applicators may exhibit compatibility problems resulting in locking, incorrect dosage or leakage.) Replace the shipping cap with the draw-off cap and tighten down. Attach draw-off tubing to the draw-off cap. Gently prime the applicator gun, checking for leaks. Follow the manufacturer's directions for adjusting the dose When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container. To prevent removal of special lubricants from the Simcro Tech gun, the gun and tubing must not be washed.

TOPICAL

IVERMAX® POUR-ON(ivermectin topical solution) for Cattle

DOSAGE: This syringe contains sufficient paste to treat one 1250 lb horse at the recommended dose rate of 91 mcg ivermectin per lb (200 mcg/kg) body weight. Each weight marking on the syringe plunger delivers enough paste to treat 250 lb body weight. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. PARASITE CONTROL PROGRAM: All horses should be included in a regular parasite control program with particular attention being paid to mares, foals and yearlings. Foals should be treated initially at 6 to 8 weeks of age, and routine treatment repeated as appropriate. Consult your veterinarian for a control program to meet your specific needs. IVERMECTIN (ivermectin paste) effectively controls gastrointestinal nematodes and bots of horses. Regular treatment will reduce the chances of verminous arteritis caused by Strongylus vulgaris. PRODUCT ADVANTAGES: Broad-spectrum Control - IVERMECTIN controls important internal parasites, including bots and the arterial stages of S. vulgaris, with a single dose. IVERMECTIN is a potent antiparasitic agent that is neither a benzimidazole nor an organophosphate. ADMINISTRATION: (1) While holding plunger, turn the knurled ring on the plunger 1/4 turn to the left and slide it so the side nearest the barrel is at the prescribed weight marking, aligning the arrow on the ring to the line between the weight and lbs, as shown in the pictogram. (2) Lock the ring in place by making a 1/4 turn to the right. Ensure it is locked (it should no longer slide). (3) Make sure that the horse's mouth contains no feed. (4) Remove the cover from the tip of the syringe. (5) Insert the syringe tip into the horse's mouth at the space between the teeth. (6) Depress the plunger as far as it will go, depositing paste on the back of the tongue. (7) Immediately raise the horse's head for a few seconds after dosing.

ORAL

Vrettsio Ivermectin Horse Paste 1.87%

This syringe contains sufficient paste to treat one 1320-lb horse at the recommended dose rate of 91 mcg ivermectin per lb (200 mcg/kg) and 0.68 mg praziquantel per lb (1.5 mg/kg) of body weight. Each weight marking on the syringe plunger delivers enough paste to treat 220 lb (100 kg) of body weight. 1. While holding plunger, turn the knurled ring on the plunger 1/4 turn to the left and slide it so the side nearest the barrel is at the prescribed weight marking. 2. Lock the ring in place by making a 1/4 turn to the right. 3. Make sure that the horse’s mouth contains no feed. 4. Remove the cover from the tip of the syringe. 5. Insert the syringe tip into the horse’s mouth at the space between the teeth. 6. Depress the plunger as far as it will go, depositing paste on the back of the tongue. 7. Immediately raise the horse’s head for a few seconds after dosing. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. Parasite Control Program: All horses should be included in a regular parasite control program with particular attention being paid to mares, foals, and yearlings. Foals should be treated initially at 4 weeks of age, and routine treatment repeated as appropriate. Consult your veterinarian for a control program to meet your specific needs. EQUIMAX Oral Paste effectively controls gastrointestinal nematodes, cestodes and bots of horses. Regular treatment will reduce the chances of colic caused by Anoplocephala perfoliata and verminous arteritis caused by Strongylus vulgaris. Product Advantages: Broad-spectrum Control: EQUIMAX Oral Paste kills important internal parasites, including tapeworms, bots and the arterial stages of S. vulgaris, with a single dose. EQUIMAX Oral Paste contains two potent antiparasitic agents that are neither benzimidazoles nor organophosphates.

ORAL

Equimax®(ivermectin 1.87% / praziquantel 14.03%) Oral Paste Anthelmintic and Boticide

DOSAGE: Ivermectin Paste 1.87% Net Wt: 0.21 oz (6.08 g) This syringe contains sufficient paste to treat one 1250 lb horse at the recommended dose rate of 91 mcg Ivermectin per lb (200 mcg/kg) body weight. Each weight marking on the syringe plunger delivers enough paste to treat 250 lb body weight. ADMINISTRATION: (1) While holding plunger, turn the knurled ring on the plunger 1/4 turn to the left and slide it so the side nearest the barrel is at the prescribed weight marking. (2) Lock the ring in place by making a 1/4 turn to the right. (3) Make sure that the horse's mouth contains no feed. (4) Remove the cover from the tip of the syringe. (5) Insert the syringe tip into the horse's mouth at the space between the teeth. (6) Depress the plunger as far as it will go, depositing paste on the back of the tongue. (7) Immediately raise the horse's head for a few seconds after dosing. PARASITE CONTROL PROGRAM : All horses should be included in a regular parasite control program with particular attention being paid to mares, foals and yearlings. Foals should be treated initially at 6 to 8 weeks of age, and routine treatment repeated as appropriate. Consult your veterinarian for a control program to meet your specific needs. Ivermectin Paste effectively controls gastrointestinal nematodes and bots of horses. Regular treatment will reduce the chances of verminous arteritis caused by Strongylus vulgaris . PRODUCT ADVANTAGES: Broad-spectrum Control– Ivermectin Paste 1.87% kills important internal parasites, including bots and the arterial stages of S. vulgaris, with a single dose. Ivermectin Paste is a potent antiparasitic agent that is neither a benzimidazole nor an organophosphate. ANIMAL SAFETY: Ivermectin Paste 1.87% may be used in horses of all ages, including mares at any stage of pregnancy. Stallions may be treated without adversely affecting their fertility.

ORAL

Ivermectin Paste

DOSAGE The dose rate is 1 mL for each 22 lb of body weight. The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. ADMINISTRATION Collapsible packs (1L, 4L, 10L and 20L) Connect the applicator gun to the collapsible pack as follows: 1. Attach the open end of the draw-off tubing to the dosing gun and attach draw-off tubing to the self-venting cap with the stem. (Because of the solvents used in Ecomectin Pour-On for Cattle (ivermectin topical solution), use dosing equipment compatible with Ecomectin Pour-On for Cattle. Follow manufacturers directions for use and care of the equipment. Other dosing equipment may be incompatible resulting in locking, incorrect dosage and leakage. 2. Replace the shipping cap with the self-venting draw-off cap which has the stem and tighten this cap. 3. Invert the pack and gently prime the dosing gun, check for leaks. 4. Follow the manufacturer’s directions for adjusting the dose. 5. When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container. 6. Follow the applicator gun manufacturer’s directions for priming the gun, adjusting the dose, and care of the applicator gun following use. Weight Dose 220 lb (100 kg) 10 mL 330 lb (150 kg) 15 mL 440 lb (200 kg) 20 mL 550 lb (250 kg) 25 mL 660 lb (300 kg) 30 mL 770 lb (350 kg) 35 mL 880 lb (400 kg) 40 mL 990 lb (450 kg) 45 mL 1100 lb (500 kg) 50 mL

TOPICAL

ECOMECTIN Cattle Pour-On (ivermectin topical solution)

Cattle: AGRI-MECTIN ® Injection is to be given subcutaneously only, to reduce risk of potentially fatal clostridial infection of the injection site.Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16-gauge, 1/2 to 3/4" needle is suggested. Inject under the loose skin in front of or behind the shoulder (see illustration). When using the 200 mL or 500 mL size, use only automatic syringe equipment. Use sterile equipment and sanitize the injection site by applying a suitable disinfectant. Clean, properly disinfected needles should be used to reduce the potential for injection site infections. No special handling or protective clothing is necessary. Swine: AGRI-MECTIN ® Injection is to be given subcutaneously in the neck. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16- or 18-gauge needle is suggested for sows and boars, while an 18- or 20-gauge needle may be appropriate for young animals. Inject under the skin, immediately behind the ear (see illustration). When using the 200 mL or 500 mL size, use only automatic syringe equipment. As with any injection, sterile equipment should be used. The injection site should be cleaned and disinfected with alcohol before injection. The rubber stopper should also be disinfected with alcohol to prevent contamination of the contents. Mild and transient pain reactions may be seen in some swine following subcutaneous administration.

SUBCUTANEOUS

AGRI-MECTIN (ivermectin)

DOSAGE Bimectin® Plus should be given only by subcutaneous injection at a dose volume of 1 mL per 110 lb. (50 kg) body weight. This volume will deliver 10 mg ivermectin and 100 mg clorsulon. For example: Body Weight (lb) Dose Volume (mL) 220 2 330 3 440 4 550 5 660 6 770 7 880 8 990 9 1100 10 ADMINISTRATION Bimectin® Plus (ivermectin and clorsulon) is to be given subcutaneously only. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16-gauge, ½” to ¾” sterile needle is recommended. Inject the solution subcutaneously (under the skin) behind the shoulder (see illustration). When using the 250 mL, 500 mL or 1000 mL package size, use only automatic syringe equipment. Use sterile equipment and sanitize the injection site by applying a suitable disinfectant. Clean, properly disinfected needles should be used to reduce the potential for injection site infections. No special handling or protective clothing is necessary. The viscosity of the product increases in cool temperatures. Administering Bimectin® Plus at temperatures of 5°C (41°F) or below may be difficult. Users can make dosing easier by warming both the product and injection equipment to about 15°C (59°F). Use within 28 days of first puncture and puncture a maximum of 14 times with a dosage delivery device. ANIMAL SAFETY In breeding animals (bulls and cows), ivermectin and clorsulon used at the recommended level had no effect on breeding performance.

SUBCUTANEOUS

FDA application 200-450

DOSAGE: This syringe contains sufficient paste to treat one 1250 lb horse at the recommended dose rate of 91 mcg Ivermectin per lb (200 mcg/kg) body weight. Each weight marking on the syringe plunger delivers enough paste to treat 250 lb body weight. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. PARASITE CONTROL PROGRAM: All horses should be included in a regular parasite control program with particular attention being paid to mares, foals and yearlings. Foals should be treated initially at 6 to 8 weeks of age, and routine treatment repeated as appropriate. Consult your veterinarian for a control program to meet your specific needs. DURAMECTIN Paste 1.87% effectively controls gastrointestinal nematodes and bots of horses. Regular treatment will reduce the chances of verminous arteritis caused by Strongylus vulgaris. PRODUCT ADVANTAGES: Broad-spectrum Control– DURAMECTIN Paste 1.87% kills important internal parasites, including bots and the arterial stages of S. vulgaris, with a single dose. DURAMECTIN Paste 1.87% is a potent antiparasitic agent that is neither a benzimidazole nor an organophosphate. ANIMAL SAFETY: DURAMECTIN Paste 1.87% may be used in horses of all ages, including mares at any stage of pregnancy. Stallions may be treated without adversely affecting their fertility.

Oral

DuraMectin (ivermectin) Paste

IVOMEC Plus (ivermectin and clorsulon) Injection is to be given subcutaneously only. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16-gauge, 1/2" to 3/4" sterile needle is recommended. Inject the solution subcutaneously (under the skin) behind the shoulder (see illustration). Any single-dose syringe or standard automatic syringe equipment may be used with the 50 mL bottle. Use the 50 mL bottle within 6 months of first puncture and puncture a maximum of 12 times. If more than 12 punctures are anticipated, the use of multi-dosing equipment is recommended. When using a draw-off spike or needle with bore diameter larger than 16-gauge, discard any product remaining in the bottle immediately after use. When using the 200 mL, 500 mL or 1000 mL pack size, use only automatic syringe equipment. Discard any product remaining in the pack immediately after use. Use sterile equipment and sanitize the injection site by applying a suitable disinfectant. Clean, properly disinfected needles should be used to reduce the potential for injection site infections. No special handling or protective clothing is necessary. The viscosity of the product increases in cool temperatures. Administering IVOMEC® Plus at temperatures of 5°C (41°F) or below may be difficult. Users can make dosing easier by warming both the product and injection equipment to about 15°C (59°F).

SUBCUTANEOUS

Ivomec® Plus (ivermectin and clorsulon) Injection for Cattle

DOSAGE The dose rate is 1 mL for each 22 lb of body weight. The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. ADMINISTRATION BackPack (5 Liter Pack) Connect the applicator gun to the backpack as follows: • Attach the open end of the draw-off tubing to the dosing equipment. (Because of the solvents used in the formulation, only the Protector Drench Gun from Instrument Supplies Limited, or equivalent, is recommended. Other applicators may exhibit compatibility problems resulting in locking, incorrect dosage or leakage). • Replace the shipping cap with the draw-off cap and tighten down. Attach draw-off tubing to the draw-off cap. • Gently prime the applicator gun, checking for leaks. • Follow the manufacturer’s directions for adjusting the dose. • When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container. To prevent removal of special lubricants from the Protector Drench Gun, the gun and tubing must not be washed.

TOPICAL

FDA application 200-318

DOSAGE: This syringe contains sufficient paste to treat one 1,250 lb horse at the recommended dose rate of 91 mcg ivermectin per lb (200 mcg/kg) of body weight. Each weight marking on the syringe plunger delivers sufficient paste to treat 250 lb of body weight. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment and may encourage the development of parasite resistance. PARASITE CONTROL PROGRAM: All horses should be included in a regular parasite control program, with particular attention given to mares, foals, and yearlings. Foals should be treated initially at 6 to 8 weeks of age, with routine treatments repeated as appropriate. Consult your veterinarian to develop a parasite control program that meets your specific needs. Ivermectin paste effectively controls gastrointestinal nematodes and bots of horses. Regular treatment reduces the likelihood of verminous arteritis caused by Strongylus vulgaris. PRODUCT ADVANTAGES: Broad-spectrum control — ivermectin paste eliminates important internal parasites of horses, including bots and the arterial stages of Strongylus vulgaris, with a single dose. Ivermectin is a potent antiparasitic agent that is neither a benzimidazole nor an organophosphate.

ORAL

PawBliss Anthelmintic and BoticideIvermectin Horse Paste 1.87

DOSAGE: This syringe contains sufficient paste to treat one 1250 lb horse at the recommended dose rate of 91 mcg ivermectin per lb (200 mcg/kg) body weight. Each weight marking on the syringe plunger delivers enough paste to treat 250 lb body weight. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. PARASITE CONTROL PROGRAM: All horses should be included in a regular parasite control program with particular attention being paid to mares, foals and yearlings. Foals should be treated initially at 6 to 8 weeks of age, and routine treatment repeated as appropriate. Consult your veterinarian for a control program to meet your specific needs. IVERMECTIN (ivermectin paste) effectively controls gastrointestinal nematodes and bots of horses. Regular treatment will reduce the chances of verminous arteritis caused by Strongylus vulgaris. PRODUCT ADVANTAGES: Broad-spectrum Control - IVERMECTIN controls important internal parasites, including bots and the arterial stages of S. vulgaris, with a single dose. IVERMECTIN is a potent antiparasitic agent that is neither a benzimidazole nor an organophosphate.

ORAL

Zimorven Ivermectin Horse Paste 1.87

Cattle: IVOMEC Injection should be given only by subcutaneous injection under the loose skin in front of or behind the shoulder at the recommended dose level of 200 mcg of ivermectin per kilogram of body weight. Each mL of IVOMEC contains 10 mg of ivermectin, sufficient to treat 110 lb (50 kg) of body weight (maximum 10 mL per injection site). Body Weight (lb) Dose Volume (mL) 220 2 330 3 440 4 550 5 660 6 770 7 880 8 990 9 1100 10 Swine: IVOMEC Injection should be given only by subcutaneous injection in the neck of swine at the recommended dose level of 300 mcg of ivermectin per kilogram (2.2 lb) of body weight. Each mL of IVOMEC contains 10 mg of ivermectin, sufficient to treat 75 lb of body weight. Body Weight (lb) Dose Volume (mL) Growing Pigs 19 1/4 38 1/2 75 1 150 2 Breeding Animals 225 3 (Sows, Gilts, and Boars) 300 4 375 5 450 6 Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.

SUBCUTANEOUS

Ivomec® (ivermectin) Injection for Cattle and Swine

Noromectin Plus (ivermectin and clorsulon) Injection is to be given subcutaneously only. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16-gauge, 1/2" to 3/4" sterile needle is recommended. Inject the solution subcutaneously (under the skin) behind the shoulder (see illustration). Any single-dose syringe or standard automatic syringe equipment may be used with the 50 mL or 100 mL pack size. When using the 250 mL, 500 mL or 1000 mL pack size, use only automatic syringe equipment. Use sterile equipment and sanitize the injection site by applying a suitable disinfectant. Clean, properly disinfected needles should be used to reduce the potential for injection site infections. No special handling or protective clothing is necessary. The viscosity of the product increases in cool temperatures. Administering Noromectin Plus at temperatures of 41°F (5°C) or below may be difficult. Users can make dosing easier by warming both the product and injection equipment to about 59°F (15°C).

SUBCUTANEOUS

Noromectin ® (ivermectin and clorsulon) PLUS

DOSAGE: This syringe contains sufficient paste to treat one 1250 lb horse at the recommended dose rate of 91 mcg ivermectin per lb (200 mcg/kg) body weight. Each weight marking on the syringe plunger delivers enough paste to treat 250 lb body weight. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. PARASITE CONTROL PROGRAM: All horses should be included in a regular parasite control program with particular attention being paid to mares, foals and yearlings. Foals should be treated initially at 6 to 8 weeks of age, and routine treatment repeated as appropriate. Consult your veterinarian for a control program to meet your specific needs. Vetrimec Paste (ivermectin paste) effectively controls gastrointestinal nematodes and bots of horses. Regular treatment will reduce the chances of verminous arteritis caused by Strongylus vulgaris.

ORAL

FDA application 200-326

Cattle: Vetrimec ™ 1% Injection is to be given subcutaneously only, to reduce risk of potentially fatal clostridial infection of the injection site. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16-gauge, ½ to ¾ inch needle is suggested. Inject under the loose skin in front of or behind the shoulder (see illustration). Any single-dose syringe or standard automatic syringe equipment may be used with the 50 mL, 100 mL, or 250 mL pack size. When using the 500 or 1000 mL pack size, use only automatic syringe equipment. Use sterile equipment and sanitize the injection site by applying a suitable disinfectant. Clean, properly disinfected needles should be used to reduce the potential for injection site infections. No special handling or protective clothing is necessary.

SUBCUTANEOUS

FDA application 200-437

Cattle: IVERMECTIN should be given only by subcutaneous injection under the loose skin in front of or behind the shoulder at the recommended dose level of 200 mcg ivermectin per kilogram of body weight. Each mL of IVERMECTIN contains 10 mg of ivermectin, sufficient to treat 110 lb (50 kg) of body weight (maximum 10 mL per injection site.). Swine : IVERMECTIN should be given only by subcutaneous injection in the neck of swine at the recommended dose level of 300 mcg ivermectin per kilogram (2.2 lb) of body weight. Each mL of IVERMECTIN contains 10 mg of ivermectin, sufficient to treat 75 lb of body weight. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment and encourage the development of parasite resistance.

SUBCUTANEOUS

IVERMECTIN INJECTION for Cattle and Swine 1% Sterile Solution

INDICATIONS For the treatment and control of internal and external parasites in livestock and horses. Also indicated for: • Large Strongyles • Small Strongyles • Pinworms • Roundworms (Ascarids) • Hairworms • Neck Threadworms • Large-mouth Stomach Worms • Bots Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. DOSAGE AND ADMINISTRATION Administer orally according to body weight: • Horses: 1 mL per 100 kg body weight • Cattle: 1 mL per 50 kg body weight • Sheep: 1 mL per 50 kg body weight • Goats: 1 mL per 40 kg body weight • Swine: 1 mL per 33 kg body weight Dosing Guidance: Use as needed based on animal condition and veterinary advice. Do not rely on fixed dosing intervals. Dosage may vary depending on parasite type and veterinary guidance.

ORAL

StrideGuardTM (IVERMECTIN) LIQUID 1.87% Oral Solution

VetriShield Plus™ (ivermectin/pyrantel) Flavored Chewables should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of roundworms and hookworms is as follows: Dog Weight Flavored Chewable Per Month Ivermectin Content Pyrantel Content Up to 25 lbs 1 68 mcg 57 mg 26 to 50 lbs 1 136 mcg 114 mg 51 to 100 lbs 1 272 mcg 227 mg VetriShield Plus™ Flavored Chewables are recommended for dogs 6 weeks of age and older. For dogs over 100 lbs use the appropriate combination of these Flavored Chewables.

oral

VetriShield Plus (ivermectin/pyrantel pamoate) Flavored Chewables

ADMINISTRATION: While holding the plunger, turn the knurled ring on the plunger one-quarter (1/4) turn to the left and slide it to the position corresponding to the prescribed weight, aligning the arrow on the ring with the line between the weight marking and “lb,” as shown in the pictogram. Lock the ring in place by making a one-quarter (1/4) turn to the right. Ensure that it is locked and no longer slides. Ensure that the horse’s mouth contains no feed. Remove the cover from the tip of the syringe. Insert the syringe tip into the horse’s mouth at the space between the teeth. Depress the plunger as far as it will go, depositing the paste on the back of the tongue. Immediately raise the horse’s head for a few seconds after dosing.

ORAL

PawBliss Anthelmintic and BoticideIvermectin Horse Paste 1.87

ADMINISTRATION: (1) While holding plunger, turn the knurled ring on the plunger 1/4 turn to the left and slide it so the side nearest the barrel is at the prescribed weight marking, aligning the arrow on the ring to the line between the weight and lbs, as shown in the pictogram. (2) Lock the ring in place by making a 1/4 turn to the right. Ensure it is locked (it should no longer slide). (3) Make sure that the horse's mouth contains no feed. (4) Remove the cover from the tip of the syringe. (5) Insert the syringe tip into the horse's mouth at the space between the teeth. (6) Depress the plunger as far as it will go, depositing paste on the back of the tongue. (7) Immediately raise the horse's head for a few seconds after dosing.

ORAL

FDA application 200-326

HEARTGARD® PLUS should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of roundworms and hookworms is as follows: HEARTGARD® PLUS is recommended for dogs 6 weeks of age and older. For dogs over 100 lbs use the appropriate combination of these chewables. Dog Weight Chewables Per Month Ivermectin Content Pyrantel Content Color Coding on Foil Backing and Carton 0 - 25 lbs 1 68 mcg 57 mg Blue 26 - 50 lbs 1 136 mcg 114 mg Green 51 - 100 lbs 1 272 mcg 227 mg Brown

ORAL

HEARTGARD® PLUS (ivermectin/pyrantel)

The dose rate is 1 mL for each 22 lb of body weight. The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead. ADMINISTRATION For the 250 mL and 1 Liter containers, see the diagram on the last page of this insert. Each 5 mL will treat 110 lbs body weight. When body weight requires a drug product volume that is between the measuring markings, use the next higher increment. Applicator Gun (2.5 L, 5 L and 5 gallon bottles) Because of the solvents used in Ivermectin Pour-On for Cattle, an applicator gun is recommended. Follow the applicator gun manufacturer’s directions for priming the gun, adjusting the dose, and care of the applicator gun following use.

TOPICAL

IVERMECTIN(ivermectin topical solution)5 mg ivermectin per mLPOUR-ON for Cattle POUR-ON for Cattle

Cattle : IVERMECTIN should be given only by subcutaneous injection under the loose skin in front of or behind the shoulder at the recommended dose level of 200 mcg ivermectin per kilogram of body weight. Each mL of IVERMECTIN contains 10 mg of ivermectin, sufficient to treat 110 lb (50 kg) of body weight (maximum 10 mL per injection site.). Swine : IVERMECTIN should be given only by subcutaneous injection in the neck of swine at the recommended dose level of 300 mcg ivermectin per kilogram (2.2 lb) of body weight. Each mL of IVERMECTIN contains 10 mg of ivermectin, sufficient to treat 75 lb of body weight.

SUBCUTANEOUS

IVERMECTIN INJECTION

Privermectin® Drench for Sheep may be used in any standard drenching equipment or in any equipment which provides a consistent dose volume. Privermectin® Drench for Sheep is administered orally at a dose of 3.0 mL (2.4 mg ivermectin) per 26 lbs body weight or 200 mcg ivermectin per kilogram of body weight. Coughing may be observed in some animals during and for several minutes following drenching. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.

ORAL

Privermectin® Drench for Sheep(ivermectin)

This syringe contains sufficient paste to treat one 1250 lb horse at the recommended dose rate of 91 mcg ivermectin per lb (200 mcg/kg) body weight and 454 mcg praziquantel per lb (1 mg/kg) body weight. Each weight marking on the syringe plunger delivers enough paste to treat 250 lb body weight. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.

ORAL

ZIMECTERIN® GOLD(ivermectin 1.55% / praziquantel 7.75%) Paste

Ivermax ® Plus should be given only by subcutaneous injection at a dose volume of 1 mL per 110 lb (50 kg) body weight. This volume will deliver 10 mg ivermectin and 100 mg clorsulon. For example: Body Weight (lb) Dose (mL) 220 2 330 3 440 4 550 5 660 6 770 7 880 8 990 9 1100 10 Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.

SUBCUTANEOUS

IVERMAX® PLUS(ivermectin and clorsulon)INJECTION FOR CATTLE

Weight/Dose Chart Weight Dose 220 lb (100 kg) 10 mL 330 lb (150 kg) 15 mL 440 lb (200 kg) 20 mL 550 lb (250 kg) 25 mL 660 lb (300 kg) 30 mL 770 lb (350 kg) 35 mL 880 lb (400 kg) 40 mL 990 lb (450 kg) 45 mL 1100 lb (500 kg) 50 mL Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment and encourage the development of parasite resistance.

TOPICAL

Vetrimec™ Pour-On(ivermectin topical solution) for Cattle

Weight Dose 220 lb (100 kg) 10 mL 330 lb (150kg) 15 mL 440 lb (200 kg) 20 mL 550 lb (250 kg) 25 mL 660 lb (300 kg) 30 mL 770 lb (350 kg) 35 mL 880 lb (400 kg) 40 mL 990 lb (450 kg) 45 mL 1100 lb (500 kg) 50 mL Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.

TOPICAL

IVERMECTIN(ivermectin topical solution)5 mg ivermectin per mLPOUR-ON for Cattle POUR-ON for Cattle

The dose rate is 1 mL for each 22 lb of body weight. The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.

TOPICAL

Ivomec® Pour-On (ivermectin topical solution)

One syringe contains sufficient paste to treat one 1250 lb horse at the recommended dose rate (0.2 mg/kg) body weight. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.

Oral

Vetr Ivermectin (1.87% ivermectin oral paste)

(2.5 L, 5 L and 5 gallon bottles) Because of the solvents used in Vetrimec™ Pour-On for Cattle, an applicator gun is recommended. Follow the applicator gun manufacturer’s directions for priming the gun, adjusting the dose, and care of the applicator gun following use.

TOPICAL

Vetrimec™ Pour-On(ivermectin topical solution) for Cattle

For the 250 mL and 1 Liter containers, see the diagram on the last page of this insert. Each 5 mL will treat 110 lbs body weight. When body weight requires a drug product volume that is between the measuring markings, use the next higher increment.

TOPICAL

Vetrimec™ Pour-On(ivermectin topical solution) for Cattle

The dose rate is 1 mL for each 22 lb of body weight. The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead.

TOPICAL

Vetrimec™ Pour-On(ivermectin topical solution) for Cattle

Each syringe contains sufficient paste to treat one 1250 lb horse at the recommended dose rate of 91 mcg ivermectin per lb (200 mcg/kg) body weight

Oral

For oral use only. Do not use in horses intended for human consumption. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism

Ivermectin Paste 1.87%

See Fact Sheet. Each mL treats 110 lb (50 kg) of body weight; 10 mL will treat an 1100 lb (500 kg) horse. Do not underdose.

ORAL

Ivermectin Liquid for Horses

1 mL for each 110 lbs (50 kg) body weight. This volume will deliver 10 mg ivermectin and 100 mg clorsulon.

Subcutaneous

Animec™ Plus