ساليسيلات الصوديوم

ساليسيلات الصوديوم (sodium salicylate) مادة من مجموعة الساليسيلات، التي يعدّها دليل MSD البيطري زمرة من مضادات الالتهاب غير الستيرويدية المشتقة من الحمض الكربوكسيلي ويمثّل لها بالأسبرين، وتصف دراسة منشورة في مجلة Journal of Swine Health and Production الساليسيلات بأنه المشتق الاستقلابي للأسبرين. ترى الوكالة الأوروبية للأدوية (EMA)، في رأي صدر عام 2008، أن ساليسيلات الصوديوم أثبت فعاليته علاجًا داعمًا في عدوى الجهاز التنفسي لدى العجول والخنازير، وأن فائدته في علاج الالتهاب مع المضادات الحيوية كانت واضحة.

آلية العمل

يحتفظ الساليسيلات، المشتق الاستقلابي للأسبرين، بأفعال مضادة للالتهاب رغم أنه لا يُبدي نشاطًا عمليًا ضد إنزيم الأكسدة الحلقية، بحسب دراسة نشرتها مجلة Journal of Swine Health and Production عام 2007. يصف دليل MSD البيطري حمض الساليسيليك، المستقلب النشط للأسبرين، بأنه مثبط تنافسي عكوس لإنزيم الأكسدة الحلقية تتحدد مدة تثبيطه أساسًا بحرائك إطراحه، وبأن نشاطه موزع بين COX-1 وCOX-2 بتوازن أكبر من الأسبرين الذي يتجه أساسًا إلى COX-1. يذكر دليل MSD البيطري أن الأسبرين والساليسيلات ينتشران بعد امتصاصهما في معظم أنسجة الجسم وسوائله، ويعبران الحاجز المشيمي بسهولة.

الأنواع الحيوانية

خلص رأي الوكالة الأوروبية للأدوية (EMA) الصادر عام 2008 إلى أن التراكيز العلاجية لساليسيلات الصوديوم تتحقق وتستمر بعد استعماله فمويًا في العجول والخنازير. تفيد دراسة مجلة Journal of Swine Health and Production بأن ساليسيلات الصوديوم المعطى عبر نظام لتدوية ماء الشرب يُمتص ويبلغ في بلازما خنازير الحضانة تراكيز قابلة للقياس. يذكر دليل MSD البيطري أن القطط تستقلب الساليسيلات ببطء، وهي حيوانات تفتقر إلى إنزيم ناقلة الغلوكورونيل.

السلامة

قد تتبع إزالة الساليسيلات من البلازما، عند فرط التعرض للأسبرين، حرائك من الرتبة الصفرية أبطأ بحسب دليل MSD البيطري، الذي يصف استقلاب الساليسيلات بأنه قابل للتشبع. في الطب البشري، يذكر دليل MSD البيطري أن الأسيتامينوفين أزاح الأسبرين والساليسيلات إلى حد بعيد عن دور المسكّن لدى البشر، لأسباب أهمها قلة خطر تقرح المعدة معه.

الوضع التنظيمي

شملت إحالة قدّمتها أيرلندا إلى الوكالة الأوروبية للأدوية (EMA) في نوفمبر 2007، بموجب المادة 35 من التوجيه 2001/82/EC، كل المساحيق الفموية الذوابة المحتوية على ساليسيلات الصوديوم والمستطبة للعجول والخنازير.

The text below is quoted verbatim from approved veterinary drug labels published by the US FDA (Animal Drugs @ FDA) and DailyMed.

Indications (6)

Species not stated (6)
  • For use in the drinking water of poultry and swine as an aid in reducing pain, fever and inflammation CALF LABEL CLAIM Indications For Use, Calves: Supportive treatment of pyrexia in acute respiratory disease, in combination with appropriate (e.g., anti-infective) therapy if necessary. Contraindications, Calves: Do not use Sodium Salicylate in neonates or calves less than 2 weeks of age Dosage, Calves: 40 mg Sodium Salicylate per kg body weight once daily, for 1-3 days. Administer orally in drinking water or milk (replacer). Recommended withdrawal period for all food animals following use at “usual dosages”: meat 24 hours.

    AquaPrime Liquid Sodium Salicylate

  • Supportive treatment of pyrexia in acute respiratory disease, in combination with appropriate (e.g., anti-infective) therapy if necessary.

    ORAL-PRO® Sodium Salicylate Concentrate 48.6% w/v

  • For use in the drinking water of poultry and swine as an aid in reducing pain, fever and inflammation.

    Aspen Sodium Salicylate 60% with Caffeine 5.7%

  • Pro-Prin is designed to provide Sodium Salicylate through the animals drinking water.

    Pro-Prin

  • For use in the drinking water of poultry and swine as an

    UNI-SOL® 60Liquid Concentrate for Drinking Water Solutions

  • Dogs Greater 1 Year of Age and over 6lbs

    DailyMed e94c39be-1c1e-493b-be00-e45063230121

Contraindications (1)

Species not stated (1)
  • Do not use Sodium Salicylate in neonates or calves less than 2 weeks of age.

    ORAL-PRO® Sodium Salicylate Concentrate 48.6% w/v

Warnings (9)

Species not stated (9)
  • Not proven safe in pregnant animals or those intended for breeding. Avoid in dogs sensitive to aspirin, with gastrointestinal issues, ulcers, bleeding liver or kidney problems. Stop usc if lameness persists after 3 days: consult Vet for vomiting, diarrhea, depression, loss of appetite, or darkened stools. ONLY FOR DOGS; GIVE WITH A MEAL. Do not mix with other anti-inflammatory drugs. Contact professional in case of overdose. Not for puppies under six months old. Keep away from children and pets.

    DailyMed e94c39be-1c1e-493b-be00-e45063230121

  • Keep container closed when not in use. Product may solidify at cold storage temperatures. Place container in room temperature storage, which will thaw the solution. If precipitate remains after thawing, place in warm water. Gently invert container to ensure dissolution and uniformity of product. Gradual darkening will not affect product stability. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

    SaliGard™ Sodium Salicylate Concentrate 60% w/v

  • Not for use in lactating dairy cattle. A withdrawal period of 24 hours is recommended in meat. Not for human use. Keep container tightly closed. Keep out of reach of children. Store at room temperature. Warning: Do not administer concentrated solution by direct oral administration — gastrointestinal irritation or overdose may occur. Do not use in piglets less than 4 weeks of age. Store at controlled room temperature between 15°-30° C (59°-86° F).

    AquaPrime Liquid Sodium Salicylate

  • Not for use in lactating dairy cattle. Do not administer concentrated solution by direct oral administration — gastro-intestinal irritation or overdose may occur. Do not use in piglets less than 3 weeks of age.

    ORAL-PRO® Sodium Salicylate Concentrate 48.6% w/v

  • Not for use in lactating dairy cattle. A withdrawal period of 24 hours is recommended in meat. Not for human use. Keep container tightly closed. Keep out of reach of children. Store at room temperature.

    AquaPrime Liquid Sodium Salicylate with Caffeine

  • CAUTION: THIS PRODUCT IS DESINGED FOR USE IN SWINE AND POULTRY ONLY. WARNINGS: DO NOT USE IN PIGLETS LESS THAN 3 WEEKS OF AGE NOT FOR HUMAN USE KEEP OUT OF THE REACH OF CHILDREN

    Pro-Prin

  • Do not administer concentrated solution by direct oral administration — gastro-intestinal irritation or overdose may occur. Do not use in piglets less than 3 weeks of age.

    ORAL-PRO® Sodium Salicylate Concentrate 60% w/v with Caffeine 5.7% w/v

  • Not for use in lactating dairy cattle Not for human use Keep out of reach of children Keep tightly closed Store at Room Temperature

    DailyMed 83a84194-1cd3-4730-bf38-225bce86bc14

  • Do not administer concentrated solution by direct oral administration — gastro-intestinal irritation or overdose may occur.

    SaliGard™ Sodium Salicylate Concentrate 60% w/v

Dosage (6)

Species not stated (6)
  • To reconstitute add 1 scoop (approximately 20 ounces) to 5 gallons of water to make stock solution. Meter 1:128 (1 fluid ounce per gallon) of drinking water. Prepare fresh stock solution daily. Repeat as needed. WATER PROPORTIONER USE: Add 20 ounces (1 scoop) of Pro-Prin to make 5 gallons of stock solution and administer through a medicator metered at 1:128 (1 ounce per gallon). THis will achieve a target does of 22.7 mg/lb (50 mg/kg) body weight daily. FOR ANTI-INFLAMMATORY/ANTI-PROSTAGLANDIN USE - DAY 1 WATER PROPROPORTIONER USE: Add 40 ounces (2 scoops) of Pro-Prin to make 5 gallons of stock solution and administer through a medicator metered at 1:128 (1 ounce per gallon). This will achieve a target does of 22.7 mg/lb (50 mg/kg) body weight daily. DAY 2 THROUGH 7 WATER PROPORTIONER USE: Add 25 ounces (1.25 scoop) of Pro-Prin to make 5 gallon of stock solution and administer through a medicator metered at 1:128 (1 ounce per gallon). This will achieve a target dose of 13.6 mg/lb (30 mg/kg) body weight daily.

    ORAL

    Pro-Prin

  • Mix the following amounts of Uni-Sol 60 into the drinking water daily as analgesic/antipyretic or anti-inflammatory for: Growing swine - ages wean to market Growing chickens - ages 0-15 weeks Growing turkeys - ages 0-24 weeks Analgesic and Antipyretic: Mix 0.6 ounces of Uni-Sol 60 per 1000 lb bodyweight (42 ml per 1000 Kg) into the drinking water daily to provide the target dose of 25 mg sodium salicylate per Kg bodyweight. Anti-Inflammatory/ Anti-prostaglandin Effect: First day- Mix 1.2 ounces of Uni-Sol 60 per 1000 lb bodyweight (84 ml per 1000 Kg) into the drinking water daily to provide the target dose of 50 mg sodium salicylate per Kg bodyweight. Following days- Mix 0.7 ounce of Uni-Sol 60 per 1000 lb bodyweight (50 ml per 1000 Kg) into the drinking water daily to provide the target dose of 30 mg sodium salicylate per Kg bodyweight. Prepare fresh solutions daily. Repeat as necessary.

    ORAL

    UNI-SOL® 60Liquid Concentrate for Drinking Water Solutions

  • Mix the following amounts of Uni-Sol® into the drinking water daily as analgesic/antipyretic or anti-inflammatory for: Growing swine - ages wean to market Growing chickens - ages 0-15 week Growing turkeys - ages 0-24 weeks Analgesic and Antipyretic: Mix 0.8 ounces of Uni-Sol® per 1000 lb bodyweight (52 ml per 1000 Kg) into th drinking water daily to provide the target dose of 25 mg sodium salicylate per Kg bodyweight. Anti-inflammatory/Anti-prostaglandin Effect: First day- Mix 1.6 ounces of Uni-Sol® per 1000 lb bodyweight (104 ml per 1000 Kg) into the drinking water daily to provide the target dose of 50 mg sodium salicylate per Kg bodyweight. Following days- Mix 1 ounce of Uni-Sol® per 1000 lb bodyweight (65 ml per 1000 Kg) into the drinking water daily to provide the target dose of 30 mg sodium salicylate per Kg bodyweight. Prepare fresh solutions daily. Repeat as necessary.

    ORAL

    UNISOL

  • Mix the following amounts of Uni-Sol into the drinking daily as analgesic/antipyretic or anti-inflammatory for: Growing Swine - ages wean to market Growing chickens - ages 0-15 weeks Growing turkeys - ages 0-24 weeks Analgesic and Antipyretic: Mix 0.8 otmces ofUni-Sol per 1000 lb bodyweight (52 ml per 1000 Kg) into the drinking water to provide the target dose of 25 mg of sodium Salicylate per Kg bodyweight. Anti-inflammatory / Anti-prostaglandin Effect: First day - Mix 1.6 ounces of Uni-Sol per 1000 lb bodyweight (65 ml per 1000 Kg) into the drinking water daily to provide the target dose of 30 mg soditm1 salicylate per Kg bodyweight. Prepare fresh solutions daily. Repeat as necessary.

    ORAL

    DailyMed 83a84194-1cd3-4730-bf38-225bce86bc14

  • Dispense Aspirin Food Topper on dog food twice daily. Refer to dosage chart based on dog's weight on label. DOG WEIGHT DOSAGE FOR EACH MEAL LESS THAN 10 LBS 1/2 PUMP (APPROXIMATELY 1ML) 10 LBS 1 PUMP (APPROXIMATELY 2 ML) 20 LBS 2 PUMP (APPROXIMATELY 4 ML) 30 LBS 3 PUMP (APPROXIMATELY 6 ML) 40 LBS 4 PUMP (APPROXIMATELY 8 ML) Over 40 LBS 1 PUMP PER 10 LBS OF BODY WEIGHT

    ORAL

    DailyMed e94c39be-1c1e-493b-be00-e45063230121

  • 40 mg Sodium Salicylate per kg body weight (4 mL per 100 lbs.) once daily, for 1–3 days. Administer orally in drinking water or milk (replacer).

    ORAL

    ORAL-PRO® Sodium Salicylate Concentrate 48.6% w/v

Available strengths (6)

ProductDosage formAvailable strengths
——28.3 g / 28.3 g
——600000 mg / 1 L
——486000 mg / 1 L
——42 mg / 1 mL
——48.6 g / 100 mL
——486 g / 1000 mL