amikacin

For treating genital tract infections (endometritis, metritis, and pyometra) in mares caused by susceptible organisms including Escherichia coli, Pseudomonas spp., and Klebsiella spp.

Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

AmiMax™ E Solution

Horses (mares)

For treating genital tract infections (endometritis, metritis, and pyometra) in mares when caused by susceptible organisms including E. coli, Pseudomonas species, and Klebsiella species.

For intrauterine infusion in the horse only. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Amiglyde-V

The drug is used in dogs for treatment of genitourinary tract infections (cystitis) caused by susceptible strains of Escherichia coli and Proteus species and skin and soft tissue infections caused by susceptible strains of Pseudomonas species and E. coli.

The drug is administered intramuscularly or subcutaneously. Treat dogs with skin and soft tissue infections for a minimum of 7 days and those with genitourinary infections for 78 to 21 days or until culture is negative and asymptomatic. If no response is observed after 3 days of treatment, therapy should be discontinued and the case reevaluated. Maximum duration of therapy should not exceed 30 days. Systemic aminoglycoside therapy is contraindicated in dogs with seriously impaired renal function. Not for use in breeding dogs as reproductive studies have not been conducted. Use with extreme caution in dogs in which hearing acuity is required for functioning. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Amiglyde-V

AMIGLYDE-V is indicated for the treatment of uterine infections (endometritis, metritis and pyometra) in mares, when caused by susceptible organisms including Escherichia coli, Pseudomonas sp and Klebsiella sp. The use of AMIGLYDE-V in eliminating infections caused by the above organisms has been shown clinically to improve fertility in infected mares. While nearly all strains of Escherichia coli, Pseudomonas sp and Klebsiella sp, including those that are resistant to gentamicin, kanamycin or other aminoglycosides, are susceptible to amikacin at levels achieved following treatment, it is recommended that the invading organism be cultured and its susceptibility demonstrated as a guide to therapy. Amikacin susceptibility discs, 30 mcg, should be used for determining in vitro susceptibility.

Amiglyde-V® (amikacin sulfate injection)Veterinary SolutionEquivalent to 250 mg amikacin per mL

Endometrial Tissue Concentrations Comparisons of amikacin activity in endometrial biopsy tissue following intrauterine infusion with that following intramuscular injection of AMIGLYDE-V in mares demonstrate superior endometrial tissue concentrations when the drug is administered by the intrauterine route. Intrauterine infusion of 2 grams AMIGLYDE-V daily for three consecutive days in mares results in peak concentrations typically exceeding 40 mcg/g of endometrial biopsy tissue within one hour after infusion. Twenty-four hours after each treatment amikacin activity is still detectable at concentrations averaging 2 to 4 mcg/g. However, the drug is not appreciably absorbed systemically following intrauterine infusion. Endometrial tissue concentrations following intramuscular injection are roughly parallel, but are typically somewhat lower than corresponding serum concentrations of amikacin.

Amiglyde-V® (amikacin sulfate injection)Veterinary SolutionEquivalent to 250 mg amikacin per mL

There are no known contraindications for the use of AMIGLYDE-V in horses other than a history of hypersensitivity to amikacin.

Amiglyde-V® (amikacin sulfate injection)Veterinary SolutionEquivalent to 250 mg amikacin per mL

Do not use in horses intended for human consumption. In vitro studies have demonstrated that when sperm are exposed to the preservative which is present in the 48 mL vials (250 mg/mL) sperm viability is impaired.

Amiglyde-V® (amikacin sulfate injection)Veterinary SolutionEquivalent to 250 mg amikacin per mL

No adverse reactions or other side effects have been reported.

Amiglyde-V® (amikacin sulfate injection)Veterinary SolutionEquivalent to 250 mg amikacin per mL

5 milligrams per pound of body weight twice daily. The drug is administered intramuscularly or subcutaneously.

Intramuscular, Subcutaneous

Treat dogs with skin and soft tissue infections for a minimum of 7 days and those with genitourinary infections for 78 to 21 days or until culture is negative and asymptomatic. If no response is observed after 3 days of treatment, therapy should be discontinued and the case reevaluated. Maximum duration of therapy should not exceed 30 days. Systemic aminoglycoside therapy is contraindicated in dogs with seriously impaired renal function. Not for use in breeding dogs as reproductive studies have not been conducted. Use with extreme caution in dogs in which hearing acuity is required for functioning. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Amikacin Sulfate Injection

5 milligrams per pound of body weight twice daily.

Intramuscular, Intrauterine, Subcutaneous

The drug is administered intramuscularly or subcutaneously. Treat dogs with skin and soft tissue infections for a minimum of 7 days and those with genitourinary infections for 78 to 21 days or until culture is negative and asymptomatic. If no response is observed after 3 days of treatment, therapy should be discontinued and the case reevaluated. Maximum duration of therapy should not exceed 30 days. Systemic aminoglycoside therapy is contraindicated in dogs with seriously impaired renal function. Not for use in breeding dogs as reproductive studies have not been conducted. Use with extreme caution in dogs in which hearing acuity is required for functioning. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Amiglyde-V

2 grams (8 milliliters) diluted with 200 milliliters of sterile physiological saline per day for 3 consecutive days.

Intrauterine

Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

AmiMax™ E Solution

Horses (mares)

Two grams (8 milliliters) diluted with 200 milliliters of sterile physiological saline per day for 3 consecutive days.

Intramuscular, Intrauterine, Subcutaneous

For intrauterine infusion in the horse only. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Amiglyde-V

For treatment of uterine infections in mares, 2 grams (8 mL) of AMIGLYDE-V, mixed with 200 mL 0.9% Sodium chloride injection, USP and aseptically infused into the uterus daily for three consecutive days, has been found to be the most efficacious dosage.

INTRAUTERINE

Amiglyde-V® (amikacin sulfate injection)Veterinary SolutionEquivalent to 250 mg amikacin per mL