selamectin

Cats (8 Weeks of Age and Older)

Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the preventionand control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilariaimmitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolution is also indicatedfor the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme)infections in cats.

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Revolution®

revolution® PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis, the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections, and the treatment and control of ear mite (Otodectes cynotis) infestations. revolution® PLUS kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated cat, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Ixodes scapularis (black-legged tick) for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

revolution® PLUS

In cats eight weeks of age and older, kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

SelaSpot™

Cats 8 weeks of age and older

Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and treatment and control of ear mite (Otodectes cynotis) infestations. Treatment and control of intestinal hookworm (Ancylostoma tubaeforme) and roundworm (Toxocara cati) infections.

Selarid®

Dogs (6 Weeks of Age or Older)

Revolution kills adult fleas and prevents flea eggs from hatching for one month andis indicated for the prevention and control of flea infestations (Ctenocephalidesfelis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment andcontrol of ear mite (Otodectes cynotis) infestations. Revolution also is indicated forthe treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the controlof tick infestations due to Dermacentor variabilis.

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Revolution®

Dogs (6 Weeks of Age or Older)

Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis. .

Selamectin

Dogs 6 weeks of age and older

Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and treatment and control of ear mite (Otodectes cynotis) infestations. Treatment and control of sarcoptic mange (Sarcoptes scabiei) and control of tick infestations due to Dermacentor variabilis.

Selarid®

In dogs six weeks of age or older, kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

SelaSpot™

INDICATIONS: SelaSpot is recommended for use in dogs six weeks of age or older and cats eight weeks of age and older for the following parasites and indications: Dogs: SelaSpot kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. SelaSpot also is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis. Cats: SelaSpot kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. SelaSpot is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

SelaSpot™ (selamectin)

Revolt is recommended for use in dogs six weeks of age or older and cats eight weeks of age and older for the following parasites and indications: Dogs: Revolt kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolt also is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis. Cats: Revolt kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolt is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

Revolt® (selamectin)Topical Parasiticide for Dogs and Cats

REVOLUTION PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis, the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections, and the treatment and control of ear mite (Otodectes cynotis) infestations. REVOLUTION PLUS kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated cat, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Ixodes scapularis (black-legged tick) for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

revolution® PLUS

Revolution is recommended for use in dogs six weeks of age or older and cats eight weeks of age and older for the following parasites and indications:

REVOLUTION® (selamectin)

Following topical administration of REVOLUTION PLUS both selamectin and sarolaner are well absorbed with mean absolute bioavailability of 40.5% and 57.9%, respectively, and distribute systemically. In cats, selamectin and sarolaner are low clearance compounds with a long half-life of 12.5 days and 41.5 days following topical administration, respectively. Following IV dose, the total body clearance for selamectin was 10.2 mL/kg/hr and for sarolaner was 3.41 mL/kg/hr. The volume of distribution at steady state was 1.26 L/kg for selamectin and 3.87 L/kg for sarolaner. The primary route of elimination for both drugs is hepatobiliary excretion (approximately 50% of dose excreted in feces). Following repeated monthly doses of REVOLUTION PLUS, there was a less than dose proportional increase in the Cmax and AUC of sarolaner and selamectin. The accumulation of both sarolaner and selamectin was observed with Cmax plateauing after the 6th dose for sarolaner and the 3rd dose for selamectin.

revolution® PLUS

Human warnings: Not for human use. Keep this and all drugs out of the reach of children. Do not come into contact with or allow children to contact the application site until 4 hours post application. In humans, REVOLUTION PLUS may be irritating to skin and eyes. REVOLUTION PLUS and selamectin topical solution contain isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Reactions such as hives, itching and skin redness have been reported in humans after accidental dermal contact with selamectin topical solution. Individuals with known hypersensitivity to selamectin topical solution should use caution or consult a health care professional before applying this product on a cat. Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water; if wearing contact lenses, rinse the eyes first then remove contact lenses and continue to rinse for 5 – 10 minutes and seek medical attention. In case of ingestion by a human, contact a physician immediately. The safety data sheet (SDS) provides more detailed occupational safety information. For a copy of the SDS or to report a suspected adverse reaction, call Zoetis at 1-888-963-8471. Flammable - Keep away from heat, sparks, open flames or other sources of ignition.

revolution® PLUS

Not for human use. Keep out of the reach of children. In humans, SENERGY may be irritating to skin and eyes. Reactions such as hives, itching and skin redness have been reported in humans in rare instances. Individuals with known hypersensitivity to SENERGY should use the product with caution or consult a health care professional. SENERGY contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water. In case of ingestion by a human, contact a physician immediately. The safety data sheet (SDS) provides more detailed occupational safety information. To report suspected adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Virbac AH, Inc. at 1-800-338-3659 or us.virbac.com. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae. Flammable - Keep away from heat, sparks, open flames or other sources of ignition. Do not use in sick, debilitated, or underweight animals (see SAFETY).

FDA application 200-670

User Safety Warnings Not for human use. Keep out of the reach of children. In humans, Revolt may be irritating to skin and eyes. Reactions such as hives, itching and skin redness have been reported in humans. Individuals with known hypersensitivity to Revolt should use the product with caution or consult a health care professional. Revolt contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water; if wearing contact lenses, rinse eyes first then remove contact lenses and continue to rinse for 5-10 minutes and seek medical attention. In case of ingestion by a human, contact a physician immediately. The safety data sheet (SDS) provides more detailed occupational safety information. To obtain a SDS contact Aurora Pharmaceutical at 1-888-215-1256 or www.aurorapharmaceutical.com. Flammable - Keep away from heat, sparks, open flames or other sources of ignition. Animal Safety Warnings Do not use in sick, debilitated or underweight animals (see TARGET ANIMAL SAFETY).

Revolt® (selamectin)Topical Parasiticide for Dogs and Cats

WARNINGS: User Safety Warnings Not for human use. Keep out of the reach of children. In humans, SelaSpot may be irritating to skin and eyes. Reactions such as hives, itching and skin redness have been reported in humans. Individuals with known hypersensitivity to SelaSpot should use the product with caution or consult a health care professional. SelaSpot contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water; if wearing contact lenses, rinse the eyes first then remove contact lenses and continue to rinse for 5-10 minutes and seek medical attention. In case of ingestion by a human, contact a physician immediately. The safety data sheet (SDS) provides more detailed occupational safety information. To obtain a SDS contact Bimeda, Inc. at 1-888-524-6332 or www.bimeda.com. Flammable - Keep away from heat, sparks, open flames or other sources of ignition. Animal Safety Warnings Do not use in sick, debilitated or underweight animals (see TARGET ANIMAL SAFETY).

SelaSpot™ (selamectin)

User Safety Warnings Not for human use. Keep out of reach of children. In humans, Selarid may be irritating to skin and eyes. Reactions such as hives, itching and skin redness have been reported in humans. Individuals with known hypersensitivity to Selarid should use the product with caution or consult a health care professional. Selarid contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water; if wearing contact lenses, rinse the eyes first then remove contact lenses and continue to rinse for 5-10 minutes and seek medical attention. In case of ingestion by a human, contact a physician immediately. The safety data sheet (SDS) provides more detailed occupational safety information. To obtain a SDS contact 1 -866-591 -5777 or www.norbrook.com. Flammable - Keep away from heat, sparks, open flames or other sources of ignition.

FDA application 200-663

In a field safety and effectiveness study, REVOLUTION PLUS was administered to cats with fleas. The study included a total of 430 cats (282 treated with REVOLUTION PLUS and 148 treated with imidacloprid + moxidectin once monthly for three treatments). Over the 90-day study period, all observations of potential adverse reactions were recorded. Reactions reported in the REVOLUTION PLUS group included those presented in the following table. Adverse Reactions by Treatment Group Adverse Reaction REVOLUTION PLUS (n = 282) Imidacloprid + moxidectin (n =148) Lethargy 12 (4.3%) 1 (0.7%) Skin lesions* 10 (3.5%) 3 (2.0%) Anorexia 9 (3.2%) 3 (2.0%) Pruritus 7 (2.5%) 3 (2.0%) Conjunctivitis 7 (2.5%) 1 (0.7%) Sneezing 6 (2.1%) 1 (0.7%) Administration site hair changes (alopecia) 5 (1.8%) 0 (0.0%) Administration site lesions (scabbing) 2 (0.7%) 0 (0.0%) *Lesions not associated with application site. In a second field safety and effectiveness study, REVOLUTION PLUS was administered to 124 cats with ear mites. Adverse reactions in cats treated with REVOLUTION PLUS included emesis, dermatitis and eczema, and pruritus. In a third field safety and effectiveness study, REVOLUTION PLUS was administered to 70 cats with hookworms. Adverse reactions in cats treated with REVOLUTION PLUS included diarrhea, anorexia, emesis, and lethargy. Post-Approval Experience (2022) The following adverse events are based on post-approval adverse drug experience reporting forREVOLUTION PLUS. Not all adverse events are reported to FDA/CVM. It is not always possible to reliably estimate the exposure using these data. The following adverse events reported in cats are listed in decreasing order of reporting frequency: Application site reactions (including alopecia, lesions, erythema, and pruritus), lethargy, anorexia, vomiting, generalized pruritus, behavioral disorders (including hiding, hyperactivity, and vocalization), ataxia, muscle tremor, diarrhea, generalized alopecia, and seizure. Contact Information To report adverse reactions call Zoetis Inc. at 1-888-963-8471. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae.

revolution® PLUS

Pre-approval clinical trials: Following treatment with selamectin, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Other signs observed (≤0.5% of 1743 treated cats and dogs) included vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors. Post-approval experience (2021): The following adverse events are based on post-approval adverse drug experience reporting for selemectin. Not all adverse events are reported to FDA/CVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using this data. The following adverse events reported for dogs are listed in decreasing order of reporting frequency: Lethargy, vomiting, diarrhea, anorexia, generalized pruritus, seizures, application site reactions (including alopecia, lesions, erythema, pruritis, and inflammation), tremors, ataxia, death, and dermatitis. The following adverse events reported for cats are listed in decreasing order of reporting frequency: Application site reactions (including alopecia, lesions, erythema, pruritus, inflammation, vesicles, blisters, and excoriations), lethargy, anorexia, vomiting, death, generalized pruritus, diarrhea, ataxia, fever, generalized alopecia, tremors, hypersalivation, dermatitis, and seizures. Contact Information: To report suspected adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Aurora Pharmaceutical at 1-888-215-1256 or www.aurorapharmaceutical.com. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae

Revolt® (selamectin)Topical Parasiticide for Dogs and Cats

ADVERSE REACTIONS: Pre-Approval Clinical Trials: Following treatment with selamectin, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Other signs observed (≤0.5% of 1743 treated cats and dogs) included vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors. Post-Approval Experience (2021): The following adverse events are based on post-approval adverse drug experience reporting for selamectin. Not all adverse events are reported to FDA/CVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using this data. The following adverse events reported for dogs are listed in decreasing order of reporting frequency: Lethargy, vomiting, diarrhea, anorexia, generalized pruritus, seizures, application site reactions (including alopecia, lesions, erythema, pruritis, and inflammation), tremors, ataxia, death, and dermatitis. The following adverse events reported for cats are listed in decreasing order of reporting frequency: Application site reactions (including alopecia, lesions, erythema, pruritis, inflammation, vesicles, blisters, and excoriations), lethargy, anorexia, vomiting, death, generalized pruritis, diarrhea, ataxia, fever, generalized alopecia, tremors, hypersalivation, dermatitis, and seizures. CONTACT INFORMATION: Contact Bimeda, Inc. at 1-888-524-6332 or www.bimeda.com. To report suspected drug experiences, contact Bimeda, Inc. at 1-888-534-6332. For additional information about reporting adverse drug experiences for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae.

SelaSpot™ (selamectin)

Pre-Approval Clinical Trials: Following treatment with Selamectin, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Other signs observed (≤0.5% of 1743 treated cats and dogs) included vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors. Post-Approval Experience (2021): The following adverse events are based on post-approval adverse drug experience reporting for selamectin. Not all adverse events are reported to FDA/CVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using this data. The following adverse events reported for dogs are listed in decreasing order of reporting frequency: Lethargy, vomiting, diarrhea, anorexia, generalized pruritus, seizures, application site reactions (including alopecia, lesions, erythema, pruritis, and inflammation), tremors, ataxia, death, and dermatitis. The following adverse events reported for cats are listed in decreasing order of reporting frequency: Application site reactions (including alopecia, lesions, erythema, pruritus, inflammation, vesicles, blisters, and excoriations), lethargy, anorexia, vomiting, death, generalized pruritus, diarrhea, ataxia, fever, generalized alopecia, tremors, hypersalivation, dermatitis, and seizures.

SelamectinTopical Parasiticide For Dogs and Cats

Pre-approval clinical trials: Following treatment with selamectin, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Other signs observed rarely (≤0.5% of 1743 treated cats and dogs) included vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors. Post-approval experience: In addition to the aforementioned clinical signs that were reported in pre-approval clinical trials, there have been reports of pruritus, urticaria, erythema, ataxia, fever, and rare reports of death. There have also been rare reports of seizures in dogs (see WARNINGS).

FDA application 200-670

Cats (8 Weeks of Age and Older)

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Revolution®

The recommended minimum dosage is 2.7 mg selamectin per pound (6.0 mg/kg) of body weight in combination with 0.45 mg sarolaner per pound (1.0 mg/kg) of body weight administered monthly.

Topical

revolution® PLUS

Administer topically 2.7 mg of selamectin per pound (6 mg per kilogram) of body weight.

Topical

SelaSpot™

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Topical

SENERGY™

Cats 8 weeks of age and older

2.7 milligrams of selamectin, topically, per pound (6 milligrams per kilogram) of body weight.

Topical

Selarid®

Dogs (6 Weeks of Age or Older)

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Topical

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Revolution®

Dogs 6 weeks of age and older

2.7 milligrams of selamectin, topically, per pound (6 milligrams per kilogram) of body weight.

Topical

Selarid®

Administer topically 2.7 mg of selamectin per pound (6 mg per kilogram) of body weight.

Topical

SelaSpot™

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Topical

SENERGY™

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight. Administer the entire contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Selamectin topically in accordance with the following tables. Cats (lb) Package color mg per tube Potency (mg/mL) Administered volume (mL) Up to 5 Mauve 15 mg 60 0.25 5.1–15 Blue 45 mg 60 0.75 15.1–22 Taupe 60 mg 60 1.0 For cats over 22 lbs use the appropriate combination of tubes. Dogs (lb) Package color mg per tube Potency (mg/mL) Administered volume (mL) Up to 5 Mauve 15 mg 60 0.25 5.1–10 Purple 30 mg 120 0.25 10.1–20 Brown 60 mg 120 0.5 20.1–40 Red 120 mg 120 1.0 40.1–85 Teal 240 mg 120 2.0 85.1–130 Plum 360 mg 120 3.0 For dogs over 130 lbs use the appropriate combination of tubes. Recommended for use in dogs 6 weeks of age and older and in cats 8 weeks of age and older. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Selamectin topically to dogs and cats prior to first use. Firmly press the cap down to puncture the seal on the Selamectin tube; a clicking sound will confirm that the cap has successfully punctured the seal. Remove the cap and check to ensure that the tip of the tube is open. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty. Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of Selamectin against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of Selamectin against fleas. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness of Selamectin against heartworm. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse. Flea Control in Dogs and Cats For the prevention and control of flea infestations, Selamectin should be administered at monthly intervals throughout the flea season, starting one month before fleas become active. In controlled laboratory studies >98% of fleas were killed within 36 hours. Results of clinical field studies using selamectin monthly demonstrated >90% control of flea infestations within 30 days of the first dose. Dogs and cats treated with selamectin, including those with pre-existing flea allergy dermatitis, showed improvement in clinical signs associated with fleas as a direct result of eliminating the fleas from the animals and their environment. If the dog or cat is already infested with fleas when the first dose of Selamectin is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. However, an environmental infestation of fleas may persist for a short time after beginning treatment with Selamectin because of the emergence of adult fleas from pupae. Heartworm Prevention in Dogs and Cats For the prevention of heartworm disease, Selamectin must be administered on a monthly basis. Selamectin may be administered year-round or at least within one month after the animal's first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose is missed and a monthly interval between dosing is exceeded then immediate administration of Selamectin and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of Selamectin must be given within a month of the last dose of the former medication. Selamectin, the active ingredient in Selamectin, is a macrocyclic lactone compound. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. Thus, in heartworm endemic regions, delaying initiation of heartworm prevention using Selamectin beyond 2 months of first exposure to infective larvae (e.g., starting puppies and kittens at >8 weeks of age), or gaps of >2 months in the administration of Selamectin during periods of heartworm transmission, increases the risk of the animal acquiring heartworms. Animals with unknown heartworm history that test negative for heartworms prior to the initiation of Selamectin may be harboring pre-patent infections at the time Selamectin was started. Testing such animals 3–4 months after initiation of Selamectin would be necessary to confirm their negative heartworm status. At the discretion of the veterinarian, cats ≥6 months of age may be tested to determine the presence of existing heartworm infections before beginning treatment with Selamectin. Cats already infected with adult heartworms can be given Selamectin monthly to prevent further infections. Ear Mite Treatment in Dogs and Cats For the treatment of ear mite (O. cynotis) infestations in dogs and cats, Selamectin should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of Selamectin will control any subsequent ear mite infestations. In the clinical field trials ears were not cleaned, and many animals still had debris in their ears after the second dose. Cleansing of the infested ears is recommended to remove the debris. Sarcoptic Mange Treatment in Dogs For the treatment of sarcoptic mange (S. scabiei) in dogs, Selamectin should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of Selamectin will control any subsequent sarcoptic mange mite infestations. Because of the difficulty in finding sarcoptic mange mites on skin scrapings, effectiveness assessments also were based on resolution of clinical signs. Resolution of the pruritus associated with the mite infestations was observed in approximately 50% of the dogs 30 days after the first treatment and in approximately 90% of the dogs 30 days after the second monthly treatment. Tick Control in Dogs For the control of tick (Dermacentor variabilis) infestations in dogs, Selamectin should be administered on a monthly basis. In heavy tick infestations, complete efficacy may not be achieved after the first dose. In these cases, one additional dose may be administered two weeks after the previous dose, with monthly dosing continued thereafter. Nematode Treatment in Cats For the treatment and control of intestinal hookworm (A. tubaeforme) and roundworm (T. cati) infections, Selamectin should be applied once as a single topical dose.

TOPICAL

SelamectinTopical Parasiticide For Dogs and Cats

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight. Administer the entire contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Revolt topically in accordance with the following tables. Cats (lb) Package Color mg per tube Potency (mg/mL) Administered volume (mL) Up to 5 Rose 15 mg 60 0.25 5.1-15 Blue 45 mg 60 0.75 15.1-22 Taupe 60 mg 60 1.0 For cats over 22 lbs use the appropriate combination of tubes. Dogs (lb) Package Color mg per tube Potency (mg/mL) Administered volume (mL) Up to 5 Rose 15 mg 60 0.25 5.1-10 Purple 30 mg 120 0.25 10.1-20 Brown 60 mg 120 0.5 20.1-40 Maroon 120 mg 120 1.0 40.1-85 Teal 240 mg 120 2.0 85.1-130 Plum 360 mg 120 3.0 For dogs over 130 lbs use the appropriate combination of tubes. Recommended for use in dogs 6 weeks of age and older and in cats 8 weeks of age and older. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Revolt topically to dogs and cats prior to first use. While holding the tube in an upright position, twist the cap to break the seal. The cap will remain on the tube. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty. Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of Revolt against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of Revolt against fleas. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness of Revolt against heartworm. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse. Flea Control in Dogs and Cats For the prevention and control of flea infestations, Revolt should be administered at monthly intervals throughout the flea season, starting one month before fleas become active. In controlled laboratory studies >98% of fleas were killed within 36 hours. Results of clinical field studies using selamectin monthly demonstrated >90% control of flea infestations within 30 days of the first dose. Dogs and cats treated with selamectin, including those with pre-existing flea allergy dermatitis, showed improvement in clinical signs associated with fleas as a direct result of eliminating the fleas from the animals and their environment. If the dog or cat is already infested with fleas when the first dose of Revolt is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. However, an environmental infestation of fleas may persist for a short time after beginning treatment with Revolt because of the emergence of adult fleas from pupae. Heartworm Prevention in Dogs and Cats For the prevention of heartworm disease, Revolt must be administered on a monthly basis. Revolt may be administered year-round or at least within one month after the animal’s first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose is missed and a monthly interval between dosing is exceeded then immediate administration of Revolt and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of Revolt must be given within a month of the last dose of the former medication. Selamectin, the active ingredient in Revolt, is a macrocyclic lactone compound. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. Thus, in heartworm endemic regions, delaying initiation of heartworm prevention using Revolt beyond 2 months of first exposure to infective larvae (e.g., starting puppies and kittens at >8 weeks of age), or gaps of >2 months in the administration of Revolt during periods of heartworm transmission, increases the risk of the animal acquiring heartworms. Animals with unknown heartworm history that test negative for heartworms prior to the initiation of Revolt may be harboring pre-patent infections at the time Revolt was started. Testing such animals 3–4 months after initiation of Revolt would be necessary to confirm their negative heartworm status. At the discretion of the veterinarian, cats ≥ 6 months of age may be tested to determine the presence of existing heartworm infections before beginning treatment with Revolt. Cats already infected with adult heartworms can be given Revolt monthly to prevent further infections. Ear Mite Treatment in Dogs and Cats For the treatment of ear mite (O. cynotis) infestations in dogs and cats, Revolt should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of Revolt will control any subsequent ear mite infestations. In the clinical field trials ears were not cleaned, and many animals still had debris in their ears after the second dose. Cleansing of the infested ears is recommended to remove the debris. Sarcoptic Mange Treatment in Dogs For the treatment of sarcoptic mange (S. scabiei) in dogs, Revolt should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of Revolt will control any subsequent sarcoptic mange mite infestations. Because of the difficulty in finding sarcoptic mange mites on skin scrapings, effectiveness assessments also were based on resolution of clinical signs. Resolution of the pruritus associated with the mite infestations was observed in approximately 50% of the dogs 30 days after the first treatment and in approximately 90% of the dogs 30 days after the second monthly treatment. Tick Control in Dogs For the control of tick (Dermacentor variabilis) infestations in dogs, Revolt should be administered on a monthly basis. In heavy tick infestations, complete efficacy may not be achieved after the first dose. In these cases, one additional dose may be administered two weeks after the previous dose, with monthly dosing continued thereafter. Nematode Treatment in Cats For the treatment and control of intestinal hookworm (A. tubaeforme) and roundworm (T. cati) infections, Revolt should be applied once as a single topical dose.

TOPICAL

Revolt® (selamectin)Topical Parasiticide for Dogs and Cats

DOSAGE AND ADMINISTRATION: The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying SelaSpot topically to dogs and cats prior to first use. Firmly press the cap down to puncture the seal on the SelaSpot tube; a clicking sound will confirm that the cap has successfully punctured the seal. Remove the cap and check to ensure that the tip of the tube is open. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty. Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of SelaSpot against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of SelaSpot against fleas. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness of SelaSpot against heartworm. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse. Flea Control in Dogs and Cats For the prevention and control of flea infestations, SelaSpot should be administered at monthly intervals throughout the flea season, starting one month before fleas become active. In controlled laboratory studies >98% of fleas were killed within 36 hours. Results of clinical field studies using selamectin monthly demonstrated >90% control of flea infestations within 30 days of the first dose. Dogs and cats treated with selamectin, including those with pre-existing flea allergy dermatitis, showed improvement in clinical signs associated with fleas as a direct result of eliminating the fleas from the animals and their environment. If the dog or cat is already infested with fleas when the first dose of SelaSpot is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. However, an environmental infestation of fleas may persist for a short time after beginning treatment with SelaSpot because of the emergence of adult fleas from pupae. Heartworm Prevention in Dogs and Cats For the prevention of heartworm disease, SelaSpot must be administered on a monthly basis. SelaSpot may be administered year-round or at least within one month after the animal's first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose is missed and a monthly interval between dosing is exceeded then immediate administration of SelaSpot and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of SelaSpot must be given within a month of the last dose of the former medication. Selamectin, the active ingredient in SelaSpot, is a macrocyclic lactone compound. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. Thus, in heartworm endemic regions, delaying initiation of heartworm prevention using SelaSpot beyond 2 months of first exposure to infective larvae (e.g., starting puppies and kittens at >8 weeks of age), or gaps of >2 months in the administration of SelaSpot during periods of heartworm transmission, increases the risk of the animal acquiring heartworms. Animals with unknown heartworm history that test negative for heartworms prior to the initiation of SelaSpot may be harboring pre-patent infections at the time SelaSpot was started. Testing such animals 3–4 months after initiation of SelaSpot would be necessary to confirm their negative heartworm status. At the discretion of the veterinarian, cats ≥6 months of age may be tested to determine the presence of existing heartworm infections before beginning treatment with SelaSpot. Cats already infected with adult heartworms can be given SelaSpot monthly to prevent further infections. Ear Mite Treatment in Dogs and Cats For the treatment of ear mite (O. cynotis) infestations in dogs and cats, SelaSpot should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of SelaSpot will control any subsequent ear mite infestations. In the clinical field trials ears were not cleaned, and many animals still had debris in their ears after the second dose. Cleansing of the infested ears is recommended to remove the debris. Sarcoptic Mange Treatment in Dogs For the treatment of sarcoptic mange (S. scabiei) in dogs, SelaSpot should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of SelaSpot will control any subsequent sarcoptic mange mite infestations. Because of the difficulty in finding sarcoptic mange mites on skin scrapings, effectiveness assessments also were based on resolution of clinical signs. Resolution of the pruritus associated with the mite infestations was observed in approximately 50% of the dogs 30 days after the first treatment and in approximately 90% of the dogs 30 days after the second monthly treatment. Tick Control in Dogs For the control of tick (Dermacentor variabilis) infestations in dogs, SelaSpot should be administered on a monthly basis. In heavy tick infestations, complete efficacy may not be achieved after the first dose. In these cases, one additional dose may be administered two weeks after the previous dose, with monthly dosing continued thereafter. Nematode Treatment in Cats For the treatment and control of intestinal hookworm (A. tubaeforme) and roundworm (T. cati) infections, SelaSpot should be applied once as a single topical dose.

TOPICAL

SelaSpot™ (selamectin)

A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying SENERGY topically to dogs and cats prior to first use. Remove the tube from the package and hold upright with the lot and expiration at the bottom. Bend the tip back until it snaps off. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty. Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of SENERGY against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of SENERGY against fleas. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness of SENERGY against heartworm. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse. Flea Control in Dogs and Cats For the prevention and control of flea infestations, SENERGY should be administered at monthly intervals throughout the flea season, starting one month before fleas become active. In controlled laboratory studies >98% of fleas were killed within 36 hours. Results of clinical field studies using selamectin monthly demonstrated >90% control of flea infestations within 30 days of the first dose. Dogs and cats treated with selamectin, including those with pre-existing flea allergy dermatitis, showed improvement in clinical signs associated with fleas as a direct result of eliminating the fleas from the animals and their environment. If the dog or cat is already infested with fleas when the first dose of selamectin is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. However, an environmental infestation of fleas may persist for a short time after beginning treatment with selamectin because of the emergence of adult fleas from pupae. Heartworm Prevention in Dogs and Cats For the prevention of heartworm disease, SENERGY must be administered on a monthly basis. SENERGY may be administered year-round or at least within one month after the animal's first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose is missed and a monthly interval between dosing is exceeded then immediate administration of SENERGY and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of SENERGY must be given within a month of the last dose of the former medication. Selamectin, the active ingredient in SENERGY, is a macrocyclic lactone compound. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. Thus, in heartworm endemic regions, delaying initiation of heartworm prevention using SENERGY beyond 2 months of first exposure to infective larvae (e.g., starting puppies and kittens at >8 weeks of age), or gaps of >2 months in the administration of SENERGY during periods of heartworm transmission, increases the risk of the animal acquiring heartworms. Animals with unknown heartworm history that test negative for heartworms prior to the initiation of SENERGY may be harboring pre-patent infections at the time SENERGY was started. Testing such animals 3–4 months after initiation of SENERGY would be necessary to confirm their negative heartworm status. At the discretion of the veterinarian, cats ≥6 months of age may be tested to determine the presence of existing heartworm infections before beginning treatment with SENERGY. Cats already infected with adult heartworms can be given SENERGY monthly to prevent further infections. Ear Mite Treatment in Dogs and Cats For the treatment of ear mite (O. cynotis) infestations in dogs and cats, SENERGY should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of SENERGY will control any subsequent ear mite infestations. In the clinical field trials ears were not cleaned, and many animals still had debris in their ears after the second dose. Cleansing of the infested ears is recommended to remove the debris. Sarcoptic Mange Treatment in Dogs For the treatment of sarcoptic mange (S. scabiei) in dogs, SENERGY should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of SENERGY will control any subsequent sarcoptic mange mite infestations. Because of the difficulty in finding sarcoptic mange mites on skin scrapings, effectiveness assessments also were based on resolution of clinical signs. Resolution of the pruritus associated with the mite infestations was observed in approximately 50% of the dogs 30 days after the first treatment and in approximately 90% of the dogs 30 days after the second monthly treatment. Tick Control in Dogs For the control of tick (Dermacentor variabilis) infestations in dogs, SENERGY should be administered on a monthly basis. In heavy tick infestations, complete efficacy may not be achieved after the first dose. In these cases, one additional dose may be administered two weeks after the previous dose, with monthly dosing continued thereafter. Nematode Treatment in Cats For the treatment and control of intestinal hookworm (A. tubaeforme) and roundworm (T. cati) infections, SENERGY should be applied once as a single topical dose.

TOPICAL

FDA application 200-670

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight. Administer the entire contents of a single dose applicator (or two applicators used in combination for dogs weighing over 130 pounds) of Selarid topically in accordance with the following tables. Cats (lb) Package color mg per applicator Potency (mg/mL) Administered volume (mL) Up to 5 Mauve 15 mg 60 0.25 5.1 – 15 Blue 45 mg 60 0.75 15.1 - 22 Taupe 60 mg 60 1.0 For cats over 22 lbs use the appropriate combination of applicators Dogs (lb) Package color mg per applicator Potency (mg/mL) Administered volume (mL) Up to 5 Mauve 15 mg 60 0.25 5.1 – 10 Purple 30 mg 120 0.25 10.1 – 20 Brown 60 mg 120 0.5 20.1 – 40 Red 120 mg 120 1.0 40.1 – 85 Teal 240 mg 120 2.0 85.1 - 130 Plum 360 mg 120 3.0 For dogs over 130 lbs use the appropriate combination of applicators. Recommended for use in dogs 6 weeks of age and older and in cats 8 weeks of age and older. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Selarid topically to dogs and cats prior to first use. Remove the applicator from the outer pouch using scissors or fold along diagonal line to expose nick; tear back at nick. Hold the applicator upright. Tap the narrow part of the applicator to ensure the contents remain within the main body of the applicator. Twist or snap back the tip. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the applicator on the skin and squeeze the applicator 3 or 4 times to empty its entire contents directly onto the skin in one spot. Keeping the applicator squeezed, drag it away from the liquid and lift to remove. Check the applicator to ensure that it is empty. Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of Selarid against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of Selarid against fleas. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness of Selarid against heartworm. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty applicators in your ordinary household refuse.

TOPICAL

Selarid ®

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight. Administer the entire contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Revolution topically in accordance with the following tables. Cats (lb) Package color mg per tube Potency (mg/mL) Administered volume (mL) Up to 5 Mauve 15 mg 60 0.25 5.1–15 Blue 45 mg 60 0.75 15.1–22 Taupe 60 mg 60 1.0 For cats over 22 lbs use the appropriate combination of tubes. Dogs (lb) Package color mg per tube Potency (mg/mL) Administered volume (mL) Up to 5 Mauve 15 mg 60 0.25 5.1–10 Purple 30 mg 120 0.25 10.1–20 Brown 60 mg 120 0.5 20.1–40 Red 120 mg 120 1.0 40.1–85 Teal 240 mg 120 2.0 85.1–130 Plum 360 mg 120 3.0 For dogs over 130 lbs use the appropriate combination of tubes. Recommended for use in dogs 6 weeks of age and older and in cats 8 weeks of age and older. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Revolution topically to dogs and cats prior to first use. Firmly press the cap down to puncture the seal on the Revolution tube; a clicking sound will confirm that the cap has successfully punctured the seal. Remove the cap and check to ensure that the tip of the tube is open. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty. Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of Revolution against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of Revolution against fleas. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness of Revolution against heartworm. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse.

TOPICAL

REVOLUTION® (selamectin)

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight. Administer the entire contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of SENERGY topically in accordance with the following tables. (See ADMINISTRATION for the recommended treatment intervals.) Cats (lb) Package Color mg per tube Potency (mg/mL) Administered volume (mL) Up to 5 Mauve 15 mg 60 0.25 5.1–15 Blue 45 mg 60 0.75 15.1–22 Taupe 60 mg 60 1.0 For cats over 22 lbs use the appropriate combination of tubes. Dogs (lb) Package Color mg per tube Potency (mg/mL) Administered volume (mL) Up to 5 Mauve 15 mg 60 0.25 5.1–10 Lavender 30 mg 120 0.25 10.1–20 Brown 60 mg 120 0.5 20.1–40 Red 120 mg 120 1.0 40.1–85 Teal 240 mg 120 2.0 85.1–130 Plum 360 mg 120 3.0 For dogs over 130 lbs use the appropriate combination of tubes. Recommended for use in dogs 6 weeks of age and older and in cats 8 weeks of age and older.

TOPICAL

FDA application 200-670