فيرجينياميسين

Used for:Liver abscess

ينتمي الفيرجينياميسين (virginiamycin) إلى مجموعة الستربتوغرامينات، وهي ببتيدات حلقية تنتجها أنواع من جنس Streptomyces، ومنها Streptomyces virginae، بوصفها مستقلبات ثانوية، بحسب تقرير الوكالة الأوروبية للأدوية (EMA) عن تقييم الفيرجينياميسين في الدواجن. في الدجاج اللاحم يُراد بالفيرجينياميسين، بحسب تقرير الوكالة الأوروبية للأدوية (EMA)، علاج التهاب الأمعاء النخري، وهو مرض معوي شائع في الدواجن كثيراً ما يودي بحياتها، وتتسبب فيه سلالات من Clostridium perfringens تنتج الذيفان.

ما هو الدواء وإلى أي صنف ينتمي

تنفرد الستربتوغرامينات بين المضادات الحيوية، بحسب تقرير الوكالة الأوروبية للأدوية (EMA)، بأن كل عضو فيها يتكوّن من جزيئين غير متشابهين بنيوياً على الأقل؛ ومن الفيرجينياميسين يمثل العامل M1 المركّب A، وهو لاكتون كبير، ويمثل العامل S1 المركّب B، وهو ببتيد دبسي حلقي سداسي. يميّز دليل MSD البيطري ضمن الستربتوغرامينات، التي يضم إليها الفيرجينياميسين، مجموعتين: A وحلقتها غير المشبعة ذات ثلاثة وعشرين عضواً، وB وهي الدبسيات الببتيدية.

آلية العمل

يذكر تقرير الوكالة الأوروبية للأدوية (EMA) أن هدف مكوّني الفيرجينياميسين كليهما هو الوحدة 50S من ريبوسوم البكتيريا. يمنع المكوّن A (M1) تعلّق الحمض النووي الريبي الناقل بموقعي المستقبِل والمانح في الريبوسوم، إذ يرتبط بجيب ضيق داخل المركز الحفزي لإنزيم ببتيديل ترانسفيراز، بحسب تقرير الوكالة الأوروبية للأدوية (EMA). على خلاف المكوّن A، لا يؤثر المكوّن B (S1) في تفاعل ببتيديل ترانسفيراز، بل يرتبط بالحمض النووي الريبي الريبوسومي 23S في نفق الخروج من الريبوسوم فيعطّل استطالة الببتيد بعد دورات قليلة من تكوين الرابطة الببتيدية، كما يذكر تقرير الوكالة الأوروبية للأدوية (EMA). يضيف تقرير الوكالة الأوروبية للأدوية (EMA) أن البنية التركيبية للمعقد الريبوسومي مهمة، لأن المكوّن S1 من الفيرجينياميسين يعمل تآزرياً مع التغير في شكل مركز ببتيديل ترانسفيراز في الوحدة 50S الذي يحدثه المكوّن M1. تصف دراسة عن أثر إضافة الفلافوفوسفوليبول والفيرجينياميسين في ميكروبيوتا الدجاج اللاحم الفيرجينياميسين بأنه من الستربتوغرامينات ويتألف من مكوّنين فعالين يكبحان تخليق البروتين بالارتباط بالحمض النووي الريبي الريبوسومي 23S في الوحدة 50S. يذكر دليل MSD البيطري أن المكوّنين A وB يعملان كلٌّ منهما منفرداً بصورة كابحة لنمو البكتيريا، أما معاً فتزداد ألفتهما للريبوسوم فيصبحان قاتلين للبكتيريا. يذكر تقرير الوكالة الأوروبية للأدوية (EMA) أن المتبقيات القابلة للاستخلاص من الفيرجينياميسين تتكون من مكونات متعددة، ما يدل على أنه يُستقلب استقلاباً واسعاً في الأنسجة.

الاستعمالات البيطرية

يذكر تقرير الوكالة الأوروبية للأدوية (EMA) أن الفيرجينياميسين معروف، إضافة إلى أثره المضاد للميكروبات، بتأثيره في وزن الجسم وكفاءة العلف. تذكر دراسة ميكروبيوتا الدجاج اللاحم أن محفّزات النمو المضادة للحيوية، ومنها الفلافوفوسفوليبول والفيرجينياميسين، استُعملت على نطاق واسع منذ عقود في إنتاج حيوانات الغذاء.

السلامة

يخلص تقرير الوكالة الأوروبية للأدوية (EMA) إلى أن الفيرجينياميسين غير سام للجينات في الجسم الحي. جاء في ملخص حرية المعلومات الخاص بمستحضر فيرجينياميسين للأبقار، الذي أعده مركز الطب البيطري في إدارة الغذاء والدواء الأمريكية (FDA CVM)، أنه لم تُلاحظ تفاعلات ضائرة تُعزى إلى الفيرجينياميسين. تذكر دراسة ميكروبيوتا الدجاج اللاحم أن الدجاج المضاف إليه الفيرجينياميسين أظهر زيادة في استعمار بكتيريا يُحتمل أن تكون ممرضة، هي Clostridium perfringens وCampylobacter وأنواع Escherichia وShigella. تشير دراسة ميكروبيوتا الدجاج اللاحم كذلك إلى أن دراسات أخرى أظهرت ارتباطاً قوياً بين استعمال الفيرجينياميسين وزيادة استعمار ممرضات انتهازية مثل Clostridium perfringens، مرتبطة بارتفاع معدلات النفوق.

الوضع التنظيمي

يذكر تقرير الوكالة الأوروبية للأدوية (EMA) أن الفيرجينياميسين يُستعمل في إنتاج الحيوانات منذ عام 1975. يذكر تقرير الوكالة الأوروبية للأدوية (EMA) أن الفيرجينياميسين كان يُستعمل سابقاً في الاتحاد الأوروبي إضافةً علفية، وأن هذا الاستعمال بقصد تحفيز النمو حُظر عام 1998 بموجب لائحة المجلس رقم 2821/98.

مقاومة المضادات الحيوية

يذكر دليل MSD البيطري في فصل الماكروليدات أن المثيلة اللاحقة للترجمة تفضي إلى مقاومة متصالبة تجاه اللينكوزاميدات والستربتوغرامينات، وتُعرف بمقاومة الماكروليدات واللينكوزاميدات والستربتوغرامين ب.

The text below is quoted verbatim from approved veterinary drug labels published by the US FDA (Animal Drugs @ FDA) and DailyMed.

Indications (46)

Chickens (21)

  • Chickens (broilers)

    For prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati, including some field strains of E. tenella which are more susceptible to roxarsone combined with salinomycin than to roxarsone alone, and for improved feed efficiency.

    Feed continuously as sole ration. Withdraw 5 days prior to slaughter. Use as sole source of organic arsenic. Not approved for use with pellet binders. Do not feed to layers. May be fatal if accidentally fed to adult turkeys or horses.

    3-Nitro® / Bio-Cox® / Stafac® Type A Medicated Articles

  • Chickens (broilers)

    For prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati, including some field strains of Eimeria tenella which are more susceptible to roxarsone combined with salinomycin than to salinomycin alone, and for improved feed.

    Feed continuously as sole ration. Use as sole source of organic arsenic. Do not feed to layers.

    3-Nitro® / Sacox® / Stafac®

  • Chickens (broilers)

    For the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati, and for increased rate or weight gain and improved feed efficiency.

    Feed continuously as sole ration. Do not feed to layers or to chickens over 16 weeks of age.

    Sacox® / Stafac®

  • Chickens (broilers)

    For increase in rate of weight gain; as an aid in the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. maxima, E. brunetti, and E. mivati.

    Do not feed to laying chickens. Feed continuously as the sole ration. Withdraw 5 days before slaughter. As sole source of organic arsenic. As monensin sodium; as roxarsone. Do not allow horses or other equines access to formulations containing monensin. Ingestion of monensin by equines has been fatal.

    3-Nitro® / Stafac® / Coban®

  • Chickens (broilers)

    For prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin in broiler chickens.

    Not for use in layers. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 500

  • Chickens (broilers)

    For increased rate of weight gain and improved feed efficiency in broiler chickens.

    Not for use in layers.

    Stafac®

  • Chickens (broilers)

    For increased rate of weight gain in broiler chickens.

    Not for use in layers.

    Stafac®

  • Broiler Chickens

    For the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mitis (mivati), and E. maxima. Because diclazuril is effective against E. maxima later in its life cycle, subclinical intestinal lesions may be present for a short time after infection. Diclazuril was shown in studies to reduce lesion scores and improve performance and health of birds challenged with E. maxima. For increased rate of weight gain in broiler chickens.

    Feed continuously as the sole ration. Do not use in hens producing eggs for human food.

    Clinacox™ / Stafac®

  • Broiler Chickens

    For the prevention of coccidiosis caused by Eimeria tenella, E. acervulina, E. maxima, E. brunetti, E. necatrix, and E. mivati/E. mitis, and for prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin in broiler chickens.

    Feed continuously as the sole ration. For broiler chickens only. Do not feed to laying hens. Do not administer to chickens producing eggs for human consumption. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Aviax® and Stafac®

  • Broiler Chickens

    For increase rate of weight gain and improved feed efficiency; and as an aid in the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati and E. maxima.

    Feed continuously as the sole ration for broiler chickens. Do not feed to laying chickens. Do not allow horses or other equines access to formulations containing monensin sodium (ingestion of monensin sodium by equines has been fatal).

    Coban® / Stafac®

  • Broiler Chicken

    For the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mitis (mivati), and E. maxima. Because diclazuril is effective against E. maxima later in its life cycle, subclinical intestinal lesions may be present for a short time after infection. Diclazuril was shown in studies to reduce lesion scores and improve performance and health of birds challenged with E. maxima. For increased rate of weight gain and improved feed efficiency in broiler chickens.

    Feed continuously as the sole ration. Do not use in hens producing eggs for human food.

    Clinacox™ / Stafac®

  • Chickens (broilers and fryers)

    For prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. brunetti, E. mivati, and E. maxima, and for increased rate of weight gain and improved feed efficiency

    For broiler and fryer chickens only. Feed continuously as sole ration. Do not feed to laying chickens.

    Avatec® / Stafac®

  • Chickens (boillers)

    As an aid in the prevention of coccidiosis where severe exposure to Eimeria acervulina, E. brunetti, and E. maxima is likely to occur, for increased rate of weight gain and improved feed efficiency

    Feed continuously as sole ration. Do not feed to laying hens. Not for chickens over 16 weeks of age. As sole source of amprolium. Do not use in Type B or Type C medicated feeds containing bentonite.

    Amprol HI-E® / Stafac®

  • Chickens (Broilers)

    For the prevention of coccidiosis caused by Eimeria tenella, E. acervulina, E. maxima, E. brunetti, E. necatrix, and E. mitis and for prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin in broiler chickens.

    Feed continuously as the sole ration. Withdraw one day before slaughter. Not for human use. For broiler chickens only. Do not feed to laying hens. Do not administer to chickens producing eggs for human consumption. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Aviax II® plus Stafac®

  • Chickens (Broiler)

    For prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin and as an aid in the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati, and E. maxima.

    Feed continuously as the sole ration for broiler chickens. Do not feed to laying chickens. Do not administer to chickens producing eggs for human consumption. The use of monensin with no withdrawal period may limit feed intake reducing weight gain. Do not allow horses or other equines, mature turkeys, or guinea fowl access to feed containing monensin. Ingestion of monensin by horses and guinea fowl has been fatal. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® and Coban™

  • Broiler and fryer chickens

    For prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin and for the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati.

    Do not feed to laying chickens. Do not feed to chickens over 16 weeks of age. Not approved for use with pellet binders. May be fatal if accidentally fed to adult turkeys or horses. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® and Bio-Cox®

  • Broiler chickens

    For the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. brunetti, E. mitis (mivati) and E. maxima; and for prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin in broiler chickens. Because diclazuril is effective against E. maxima later in its life cycle, subclinical intestinal lesions may be present for a short time after infection. Diclazuril was shown in studies to reduce lesion scores and improve performance and health of birds challenged with E. maxima.

    Clinacox® and Stafac®

  • Broiler chickens

    For prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin and for the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati, and E. maxima in broiler chickens.

    Stafac® and Monteban™

  • Broiler chickens

    For prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin; and for the prevention of coccidiosis where immunity to coccidiosis is not desired in broiler chickens.

    Use as the sole source of amprolium. Do not use in feeds containing bentonite. Do not change the litter while giving this feed unless absolutely necessary. If losses exceed 0.5% in a 2-day period, obtain an accurate diagnosis and follow the instructions of your veterinarian or poultry pathologist. Losses may result from intercurrent disease or other conditions affecting drug intake, which can contribute to the virulence of coccidiosis under field conditions. Increasing levels of amprolium may not prevent coccidiosis caused by strains of Eimeria commonly found to be resistant to amprolium. Not for use in laying chickens. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® and AMPROL®

  • Broiler chickens

    For prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin; and for the prevention of coccidiosis caused by E. tenella in broiler chickens.

    For field conditions where only E. tenella is the major problem, feed continuously as the sole ration. Use as the sole source of amprolium. Do not use in feeds containing bentonite. Do not change the litter while giving this feed unless absolutely necessary. If losses exceed 0.5% in a 2-day period, obtain an accurate diagnosis and follow the instructions of your veterinarian or poultry pathologist. Losses may result from intercurrent disease or other conditions affecting drug intake, which can contribute to the virulence of coccidiosis under field conditions. Increasing levels of amprolium may not prevent coccidiosis caused by strains of Eimeria commonly found to be resistant to amprolium. Not for use in laying chickens. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® and AMPROL®

  • Broiler and fryer Chickens

    For the prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin and for the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. brunetti, E. mivati and E. maxima.

    Do not feed to laying chickens. For broiler or fryer chickens only. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® and Avatec®

Swine (11)

  • Swine (under 120 pounds)

    As an aid in control of dysentery in swine up to 120 pounds. For use in animals or on premises with a history of swine dysentery but where symptoms have not yet occurred.

    Not for use in breeding swine over 120 pounds. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 500

  • Swine (under 120 pounds)

    For treatment and control of swine dysentery in swine up to 120 pounds.

    Not for use in breeding swine over 120 pounds. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 500

  • Swine (under 120 pounds)

    For increased rate of weight gain and improved feed efficiency.

    For continuous use from weaning to market weight.

    Stafac® 10

  • Swine (over 120 pounds)

    For treatment of swine dysentery in non-breeding swine over 120 pounds.

    Not for use in breeding swine over 120 pounds. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 500

  • Swine (over 120 pounds)

    For increased rate of weight gain.

    For continuous use from weaning to market weight. Not for use in breeding swine over 120 pounds.

    Stafac®

  • Swine (over 120 pounds)

    For treatment of swine dysentery.

    Not for use in breeding swine over 120 pounds.

    Stafac®

  • Swine (up to 120 lbs)

    As an aid in control of dysentery in swine up to 120 pounds. For use in animals or on premises with a history of swine dysentery but where symptoms have not yet occurred.

    Not for use in breeding swine over 120 pounds. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 10

  • Swine (up to 120 lbs)

    For treatment and control of swine dysentery in swine up to 120 pounds.

    Not for use in breeding swine over 120 pounds. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 10

  • Swine (over 120 lbs)

    For treatment of swine dysentery in nonbreeding swine over 120 pounds.

    Not for use in breeding swine over 120 pounds. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 20

  • Swine (up to 120 pounds)

    As an aid in control of dysentery. For use in animals or on premises with a history of swine dysentery but where symptoms have not yet occurred.

    Stafac®

  • Swine (up to 120 pounds)

    For increased rate of weight gain and improved feed efficiency.

    For continuous use from weaning to market weight.

    Stafac®

Cattle (7)

  • Cattle Fed in Confinement for Slaughter

    For reduction of incidence of liver abscesses.

    Feed continuously as sole ration to cattle fed in confinement for slaughter. Not for use in animals intended for breeding. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    V-Max®

  • Cattle/growing beef steers and heifers fed in confinement for slaughter

    For increased rate of weight gain and improved feed efficiency, the prevention and control of coccidiosis caused by Eimeria bovis and Eimeria zuernii, and reduction of incidence of liver abscesses in growing beef steers and heifers fed in confinement for slaughter during the last 28 to 42 days on feed when ractopamine hydrochloride is used as a top dress with rations containing monensin and virginiamycin.

    Optaflexx™ and Rumensin™ and V-Max®

  • Cattle/growing beef steers and heifers fed in confinement for slaughter

    For increased rate of weight gain, improved feed efficiency, increased carcass leanness, the prevention and control of coccidiosis caused by Eimeria bovis and Eimeria zuernii, and reduction of incidence of liver abscesses in growing beef steers and heifers fed in confinement for slaughter during the last 28 to 42 days on feed.

    Optaflexx™ and Rumensin™ and V-Max®

  • Cattle/growing beef steers and heifers fed in confinement for slaughter

    For reduction of ammonia gas emissions per pound of live weight and hot carcass weight, the prevention and control of coccidiosis caused by Eimeria bovis and Eimeria zuernii, and reduction of incidence of liver abscesses in growing beef steers and heifers fed in confinement for slaughter during the last 14 to 91 days on feed.

    Experior™ and Rumensin™ and V-Max®

  • Cattle/growing beef steers and heifers fed in confinement for slaughter

    For reduction of ammonia gas emissions per pound of live weight and hot carcass weight, improved feed efficiency, and reduction of incidence of liver abscesses in growing beef steers and heifers fed in confinement for slaughter during the last 14 to 91 days on feed.

    Experior™ and Rumensin™ and V-Max®

  • Cattle/growing beef steers and heifers fed in confinement for slaughter

    For the prevention and control of coccidiosis caused by Eimeria bovis and Eimeria zuernii, and reduction of incidence of liver abscesses in growing beef steers and heifers fed in confinement for slaughter.

    Rumensin™ and V-Max®

  • Cattle/growing beef steers and heifers fed in confinement for slaughter

    For improved feed efficiency and reduction of incidence of liver abscesses in growing beef steers and heifers fed in confinement for slaughter.

    Rumensin™ and V-Max®

Turkeys (2)

  • For the prevention of coccidiosis caused by Eimeria meleagrimitis, E. gallopavonis, and E. adenoeides, and for increased rate of weight gain and improved feed efficiency in growing turkeys.

    Feed continuously as the sole ration For growing turkeys only.

    Avatec® / Stafac®

  • Growing Turkeys

    For the prevention of coccidiosis caused by Eimeria adenoeides, E. meleagrimitis, and E. gallopavonis, and for increased rate of weight gain and improved feed efficiency in growing turkeys.

    For growing turkeys only. Feed continuously as sole ration. Do not allow horses, other equines, mature turkeys, or guinea fowl access to feed containing monensin. Ingestion of monensin by horses, mature turkeys, and guinea fowl has been fatal. Some strains of turkey coccidia may be monensin tolerant or resistant. Monensin may interfere with development of immunity to turkey coccidiosis. Do not allow horses, other equines, mature turkeys, or guinea fowl access to feed containing monensin. Ingestion of monensin by horses, mature turkeys, and guinea fowl has been fatal. Some strains of turkey coccidia may be monensin tolerant or resistant. Monensin may interfere with development of immunity to turkey coccidiosis.

    Coban® / Stafac®

Species not stated (5)

  • Important: Must be diluted in feed before use Follow Directions on Back Panel V-Max is a registered trademark of Phibro Animal Health Corporation Phibro Animal Health Corporation, Teaneck, NJ 07666 Approved by FDA under NADA # 140-998 8812000 101-9141-06 NET CONTENTS: 50 lb (22.7 kg) Distributed by: PHIBRO ANIMAL HEALTH, INC. Teaneck, NJ 07666, USA

    V-MaxTM 50 (Virginiamycin) TYPE A MEDICATED ARTICLE

  • NOT FOR HUMAN USE RESTRICTED DRUG (CALIFORNIA) – USE ONLY AS DIRECTED HeplafleX, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates. Approved by FDA under NADA # 140-998 8812000 101-9142-01A Distributed by: Elanco US Inc. Indianapolis, IN 46221

    HepafleXTM 50 (Virginiamycin) TYPE A MEDICATED ARTICLE

  • (20 g virginiamycin activity per lb) For use in swine and poultry feeds as specified below

    Stafac® 20 (virginiamycin) TYPE A MEDICATED ARTICLE

  • NOT FOR HUMAN USE RESTRICTED DRUG (CALIFORNIA) – USE ONLY AS DIRECTED

    V-MaxTM 50 (Virginiamycin) TYPE A MEDICATED ARTICLE

  • Important: Must be diluted in feed before use

    HepafleXTM 50 (Virginiamycin) TYPE A MEDICATED ARTICLE

Warnings (4)

Species not stated (4)

  • CAUTION: Federal law restricts medicated feed containing this veterinary feed directive drug to use by or on the order of a licensed veterinarian. For further manufacture only. Follow Directions on Back Panel Stafac is registered trademark of Phibro Animal Health Corporation Phibro Animal Health Corporation, Teaneck, NJ 07666 Net Weight 50 lb (22.6 kg) Distributed by: Phibro Animal Health Corporation Teaneck, NJ 07666 Approved by FDA under NADA # 091-467 9910000 101-9107-10

    Stafac® 50 (virginiamycin) TYPE A MEDICATED ARTICLE

  • CAUTION: Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    V-MaxTM 50 (Virginiamycin) TYPE A MEDICATED ARTICLE

  • NOT FOR HUMAN USE Restricted Drug (California) – Use Only as Directed

    Stafac® 20 (virginiamycin) TYPE A MEDICATED ARTICLE

  • To be mixed in cattle feed

    HepafleXTM (virginiamycin) Type A Medicated Article

Dosage (51)

Chickens (22)

  • Chickens (broilers)

    Salinomycin 40 to 60 grams per ton of feed, virginiamycin 5 grams per ton of feed, and roxarsone 45.4 grams per ton of feed.

    Oral

    Feed continuously as sole ration. Use as sole source of organic arsenic. Do not feed to layers.

    3-Nitro® / Sacox® / Stafac®

  • Chickens (broilers)

    Halofuginone 2.72 grams (0.0003 percent) per ton of feed plus virginiamycin 5 to 15 grams per ton of feed.

    Oral

    Feed continuously as sole ration. Withdraw 6 days before slaughter. Do not feed to layers.

    Stafac® / Stenorol®

  • Chickens (broilers)

    Monensin 90 to 110 grams, plus virginiamycin, 5 to 15 grams, and roxarsone, 22.7 grams (0.0025 percent).

    Oral

    Do not feed to laying chickens. Feed continuously as the sole ration. Withdraw 5 days before slaughter. As sole source of organic arsenic. As monensin sodium; as roxarsone. Do not allow horses or other equines access to formulations containing monensin. Ingestion of monensin by equines has been fatal.

    3-Nitro® / Stafac® / Coban®

  • Chickens (broilers)

    Salinomycin 40 to 60 grams and virginiamycin 5 to 15 grams per ton of feed.

    Oral

    Feed continuously as sole ration. Do not feed to layers or to chickens over 16 weeks of age.

    Bio-Cox® / Stafac® 10 Type A Medicated Article

  • Chickens (broilers)

    Salinomycin 40 to 60 grams and virginiamycin 5 to 15 grams.

    Oral

    Feed continuously as sole ration. Do not feed to layers or to chickens over 16 weeks of age.

    Sacox® / Stafac®

  • Chickens (broilers)

    5 to 15 grams per ton of feed.

    Oral

    Not for use in layers.

    Stafac®

  • Chickens (broilers)

    20 grams per ton of feed.

    Oral

    Not for use in layers.

    Stafac®

  • Chickens (broilers)

    20 grams per ton

    Oral

    Not for use in layers. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 500

  • Broiler Chickens

    22.7 grams semduramicin and 20 grams ton virginiamycin per ton of Type C medicated feed

    Oral

    Feed continuously as the sole ration. For broiler chickens only. Do not feed to laying hens. Do not administer to chickens producing eggs for human consumption. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Aviax® and Stafac®

  • Broiler Chickens

    Diclazuril: 0.91 g/ton (1 ppm) Virginiamycin: 5 to 15 g/ton

    Oral

    Feed continuously as the sole ration. Do not use in hens producing eggs for human food.

    Clinacox™ / Stafac®

  • Broiler Chickens

    Virginiamycin: 5 - 15 g/ton Monensin sodium: 90 - 110 g/ton

    Oral

    Feed continuously as the sole ration for broiler chickens. Do not feed to laying chickens. Do not allow horses or other equines access to formulations containing monensin sodium (ingestion of monensin sodium by equines has been fatal).

    Coban® / Stafac®

  • Broiler Chicken

    Diclazuril: 0.91 g/ton (1 ppm) Virginiamycin: 5 g/ton

    Oral

    Feed continuously as the sole ration. Do not use in hens producing eggs for human food.

    Clinacox™ / Stafac®

  • Chickens (broilers and fryers)

    68 (0.0075 percent) to 113 (0.0125 percent) grams Lasalocid sodium per ton of feed in combination with Virginiamycin 20 grams per ton of feed.

    Oral

    For broiler and fryer chickens only. Feed continuously as sole ration. Do not feed to laying chickens.

    Avatec® / Stafac®

  • Chickens (boillers)

    Amprolium 113.5 (0.0125 percent) grams per ton of feed and ethopabate 36.3 (0.004 percent) grams per ton of feed in combination with Virginiamycin, 5 to 15 grams per ton of feed.

    Oral

    Feed continuously as sole ration. Do not feed to laying hens. Not for chickens over 16 weeks of age. As sole source of amprolium. Do not use in Type B or Type C medicated feeds containing bentonite.

    Amprol HI-E® / Stafac®

  • Chickens (Broilers)

    22.7 grams semduramicin and 20 grams virginiamycin per ton of Type C medicated feed

    Oral

    Feed continuously as the sole ration. Withdraw one day before slaughter. Not for human use. For broiler chickens only. Do not feed to laying hens. Do not administer to chickens producing eggs for human consumption. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Aviax II® plus Stafac®

  • Chickens (Broiler)

    Feed 20 g virginiamycin and 90 to 110 g monensin per ton of feed continuously as the sole ration for broiler chickens.

    Oral

    Feed continuously as the sole ration for broiler chickens. Do not feed to laying chickens. Do not administer to chickens producing eggs for human consumption. The use of monensin with no withdrawal period may limit feed intake reducing weight gain. Do not allow horses or other equines, mature turkeys, or guinea fowl access to feed containing monensin. Ingestion of monensin by horses and guinea fowl has been fatal. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® and Coban™

  • Broiler and fryer chickens

    Feed continuously 20 g virginiamycin and 40 to 60 g salinomycin per ton of Type C medicated feed to broiler and fryer chickens.

    Oral

    Do not feed to laying chickens. Do not feed to chickens over 16 weeks of age. Not approved for use with pellet binders. May be fatal if accidentally fed to adult turkeys or horses. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® and Bio-Cox®

  • Broiler chickens

    20 g/ton of virginiamycin (as Stafac®) and 54 to 90 g/ton of narasin and nicarbazin (as Maxiban™; 27 to 45 g/ton narasin and 27 to 45 g/ton nicarbazin, in a 1:1 ratio to create 54 to 90 g/ton). Feed as the sole ration.

    Oral

    Stafac® and Maxiban™

  • Broiler chickens

    0.91 grams (1 ppm) diclazuril and 20 grams virginiamycin per ton of Type C medicated feed.Feed as the sole ration.

    Oral

    Clinacox® and Stafac®

  • Broiler chickens

    20 g/ton of virginiamycin (as Stafac®) and 54 to 90 g/ton of narasin (as Monteban™). Feed as the sole ration.

    Oral

    Stafac® and Monteban™

  • Broiler chickens

    20 grams virginiamycin and 72.6 to 113.5 grams amprolium per ton of Type C medicated feed.

    Oral

    For field conditions where only E. tenella is the major problem, feed continuously as the sole ration. Use as the sole source of amprolium. Do not use in feeds containing bentonite. Do not change the litter while giving this feed unless absolutely necessary. If losses exceed 0.5% in a 2-day period, obtain an accurate diagnosis and follow the instructions of your veterinarian or poultry pathologist. Losses may result from intercurrent disease or other conditions affecting drug intake, which can contribute to the virulence of coccidiosis under field conditions. Increasing levels of amprolium may not prevent coccidiosis caused by strains of Eimeria commonly found to be resistant to amprolium. Not for use in laying chickens. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® and AMPROL®

  • Broiler and fryer Chickens

    Feed continuously as the sole ration 20 g virginiamycin and 68 to 113 g lasalocid sodium per ton of Type C medicated feed for broiler and fryer chickens.

    Oral

    Do not feed to laying chickens. For broiler or fryer chickens only. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® and Avatec®

Swine (13)

  • Swine (under 120 pounds)

    100 grams per ton of feed for 2 weeks, 50 grams per ton of feed thereafter.

    Oral

    Stafac®

  • Swine (under 120 pounds)

    100 grams per ton for 2 weeks, 50 grams per ton thereafter

    Oral

    Not for use in breeding swine over 120 pounds. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 500

  • Swine (under 120 pounds)

    10 grams per ton of feed from weaning up to 120 pounds.

    Oral

    For continuous use from weaning to market weight.

    Stafac® 10

  • Swine (under 120 pounds)

    25 grams per ton

    Oral

    Not for use in breeding swine over 120 pounds. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 500

  • Swine (over 120 pounds)

    5 to 10 grams per ton of feed from 120 pounds to market weight.

    Oral

    For continuous use from weaning to market weight. Not for use in breeding swine over 120 pounds.

    Stafac®

  • Swine (over 120 pounds)

    5 to 10 grams per ton of feed to market weight.

    Oral

    For continuous use from weaning to market weight. Not for use in breeding swine over 120 pounds.

    Stafac® 10

  • Swine (over 120 pounds)

    100 grams per ton of feed for 2 weeks.

    Oral

    Not for use in breeding swine over 120 pounds.

    Stafac®

  • Swine (over 120 pounds)

    100 grams per ton for 2 weeks

    Oral

    Not for use in breeding swine over 120 pounds. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 500

  • Swine (up to 120 lbs)

    100 grams per ton for 2 weeks, 50 grams per ton thereafter

    Oral

    Not for use in breeding swine over 120 pounds. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 10

  • Swine (up to 120 lbs)

    25 grams per ton

    Oral

    Not for use in breeding swine over 120 pounds. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 10

  • Swine (over 120 lbs)

    100 grams per ton for 2 weeks

    Oral

    Not for use in breeding swine over 120 pounds. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    Stafac® 20

  • Swine (up to 120 pounds)

    10 grams per ton of feed from weaning up to 120 pounds.

    Oral

    For continuous use from weaning to market weight.

    Stafac®

  • Swine (up to 120 pounds)

    25 grams per ton of feed.

    Oral

    Stafac®

Cattle (7)

  • Cattle Fed in Confinement for Slaughter

    13.5 to 16.0 grams per ton to provide 85 to 240 milligrams per head per day in feed.

    Oral

    Feed continuously as sole ration to cattle fed in confinement for slaughter. Not for use in animals intended for breeding. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

    V-Max®

  • Cattle/growing beef steers and heifers fed in confinement for slaughter

    8.2 to 24.6 g/ton of ractopamine hydrochloride (as Optaflexx™) to provide 70 to 400 mg/head/day of ractopamine hydrochloride, 10 to 40 g/ton of monensin (as Rumensin™) to provide 0.14 to 0.42 mg/lb body weight per day, depending on the severity of coccidiosis challenge, up to 480 mg/head/day of monensin, and 13.5 to 16 g/ton of virginiamycin (as V-Max®) to provide 85 to 240 mg/head/day of virginiamycin. Feed a minimum of 1.0 lb per head per day of this Type C top-dress medicated feed during the last 28 to 42 days on feed.

    Oral

    Optaflexx™ and Rumensin™ and V-Max®

  • Cattle/growing beef steers and heifers fed in confinement for slaughter

    8.2 to 24.6 g/ton of ractopamine hydrochloride (as Optaflexx™) to provide 70 to 430 mg/head/day of ractopamine hydrochloride, 10 to 40 g/ton of monensin (as Rumensin™) to provide 0.14 to 0.42 mg/lb body weight per day, depending on the severity of coccidiosis challenge, up to 480 mg/head/day of monensin, and 13.5 to 16 g/ton of virginiamycin (as V-Max®) to provide 85 to 240 mg/head/day of virginiamycin. Feed at every feeding as a sole ration during the last 28 to 42 days on feed.

    Oral

    Optaflexx™ and Rumensin™ and V-Max®

  • Cattle/growing beef steers and heifers fed in confinement for slaughter

    1.25 to 4.54 g/ton of lubabegron (as lubabegron fumarate) (as Experior™) to provide 13 to 90 mg/head/day of lubabegron, 10 to 40 g/ton of monensin (as Rumensin™) to provide 0.14 to 0.42 mg/lb body weight per day, depending on the severity of coccidiosis challenge, up to 480 mg/head/day of monensin, and 13.5 to 16 g/ton of virginiamycin (as V-Max®) to provide 85 to 240 mg/head/day of virginiamycin. Feed at every feeding as sole ration during the last 14 to 91 days on feed.

    Oral

    Experior™ and Rumensin™ and V-Max®

  • Cattle/growing beef steers and heifers fed in confinement for slaughter

    1.25 to 4.54 g/ton of lubabegron (as lubabegron fumarate) (as Experior™) to provide 13 to 90 mg/head/day of lubabegron, 5 to 40 g/ton of monensin (as Rumensin™) to provide 50 to 480 mg/head/day of monensin, and 13.5 to 16 g/ton of virginiamycin (as V-Max®) to provide 85 to 240 mg/head/day of virginiamycin. Feed at every feeding as sole ration during the last 14 to 91 days on feed.

    Oral

    Experior™ and Rumensin™ and V-Max®

  • Cattle/growing beef steers and heifers fed in confinement for slaughter

    10 to 40 g/ton of monensin (as Rumensin™) to provide 0.14 to 0.42 mg/lb body weight per day, depending on the severity of coccidiosis challenge, up to 480 mg/head/day of monensin and 13.5 to 16 g/ton of virginiamycin (as V-Max®) to provide 85 to 240 mg/head/day of virginiamycin. Feed at every feeding.

    Oral

    Rumensin™ and V-Max®

  • Cattle/growing beef steers and heifers fed in confinement for slaughter

    5 to 40 g/ton of monensin (as Rumensin™) to provide 50 to 480 mg/head/day of monensin and 13.5 to 16 g/ton of virginiamycin (as V-Max®) to provide 85 to 240 mg/head/day of virginiamycin. Feed at every feeding.

    Oral

    Rumensin™ and V-Max®

Turkeys (2)

  • Lasalocid: 68 to 113 glton Virginiamycin :10 to 20 g/ton

    Oral

    Feed continuously as the sole ration For growing turkeys only.

    Avatec® / Stafac®

  • Growing Turkeys

    Monensin, 54 to 90 grams, with virginiamycin, 10 to 20 grams.

    Oral

    For growing turkeys only. Feed continuously as sole ration. Do not allow horses, other equines, mature turkeys, or guinea fowl access to feed containing monensin. Ingestion of monensin by horses, mature turkeys, and guinea fowl has been fatal. Some strains of turkey coccidia may be monensin tolerant or resistant. Monensin may interfere with development of immunity to turkey coccidiosis. Do not allow horses, other equines, mature turkeys, or guinea fowl access to feed containing monensin. Ingestion of monensin by horses, mature turkeys, and guinea fowl has been fatal. Some strains of turkey coccidia may be monensin tolerant or resistant. Monensin may interfere with development of immunity to turkey coccidiosis.

    Coban® / Stafac®

Species not stated (7)

  • Preparation ofType B Medicated Feeds for cattle fed in confinement for slaughter—Thoroughly mix the following amounts of V-Max 50 Type A Medicated Article to make 1 ton of Type B Medicated Feed to provide the concentrations shown in Table 1. An intermediate blending step, consistent with the mixing equipment specifications, should be performed to ensure adequate mixing. Table 1. Type B Medicated Feed lb of V-Max 50 Type A Medicated Article per ton of supplement Virginiamycin concentration in Type B Medicated Feed (g/ton) 5 10 20 40 100 200 250 500 1,000 2,000 5,000 10,000 Preparation of Type C Medicated Feed for cattle fed in confinement for slaughter: From Type B Medicated Feed: The Type B Medicated Feed must be diluted to a Type C Medicated Feed before being fed. Prepare a Type B Medicated Feed as described above. Thoroughly mix the V-Max 50 Type B Medicated Feed to make 1 ton of Type C Medicated Feed to provide 13.5 16.0 g of virginiamycin per ton of complete feed on a 90% dry matter basis using the examples provided in Table 2. Table 2. Type C Medicated Feed prepared from V-Max 50 Type B Medicated Feed lb of a 500g/ton Type B Medicated Feed per ton of complete feed lb of a 1,000 g/ton Type B Medicated Feed per ton of complete feed lb of a 5,000 g/ton Type B Medicated Feed per ton of complete feed lb of a 10,000 g/ton Type B Medicated Feed per ton of complete feed Virginiamycin concentration in complete feed 90% dry matter basis (g/ton) 54 27 5.4 2.7 13.5 64 32 6.4 3.2 16.0 From Type A Medicated Article: V-Max 50 Type A Medicated Article must be diluted to a Type C Medicated Feed before being fed. Thoroughly mix the Type A Medicated Article to make 1 ton of Type C Medicated Feed to provide 13.5 – 16.0 g of virginiamycin per ton of complete feed on a 90% dry matter basis using the examples provided in Table 3. An intermediate blending step, consistent with the blending equipment specifications, should be performed to ensure adequate mixing. Table 3. Type C Medicated Feed prepared from V-Max 50 Type A Medicated Article lb of V-Max 50 Type A Medicated Article per ton of complete feed Virginiamycin concentration in complete feed 90% dry matter basis (g/ton) 0.27 0.32 13.5 16.0 Feed continuously as sole ration

    ORAL

    V-MaxTM 50 (Virginiamycin) TYPE A MEDICATED ARTICLE

  • Preparation ofType B Medicated Feeds for cattle fed in confinement for slaughter: Thoroughly mix 20 lb of HeplafleX 50 Type A Medicated Article per ton of Type B medicated feed to provide 1,000 g/ton virginiamycin. An intermediate blending step, consistent with the mixing equipment specifications, should be performed to ensure adequate mixing. Preparation of Type C Medicated Feed for cattle fed in confinement for slaughter: From Type B Medicated Feed: The Type B Medicated Feed must be diluted to a Type C medicated feed before being fed. Prepare a Type B Medicated Feed as described above. Thoroughly mix the Type B medicated feed to make 1 ton of Type C medicated feed to provide 13.5 - 16.0 g of virginiamycin per ton of complete feed on a 90% dry matter basis using the examples provided in Table 1. Table 1. Type Cmedicated feed prepared from Type B medicated feed lb of 1,000 g/ton Type B medicated feed per ton of complete feed Virginiamycin concentration in complete feed 90% dry matter basis (g/ton) 27 32 13.5 16.0 From Type A Medicated Article: HeplafleX 50 Type A Medicated Feed must be diluted to a Type C medicated feed before being fed. Thoroughly mix the Type A medicated feed to make 1 ton of Type C medicated feed to provide 13.5 - 16.0 g of virginiamycin per ton of complete feed on a 90% dry matter basis using the examples provided in Table 2. An intermediate blending step, consistent with the mixing equipment specifications, should be performed to ensure adequate mixing. Table 2. Type C medicated feed prepared from HepafleX 50 Type A medicated feed lb of 1,000 g/ton Type B medicated feed per ton of complete feed Virginiamycin concentration in complete feed 90% dry matter basis (g/ton) 0.27 0.32 13.5 16.0

    ORAL

    HepafleXTM 50 (Virginiamycin) TYPE A MEDICATED ARTICLE

  • Mixing Directions—Swine Stafac 50 Type A Medicated Article must be thoroughly mixed in the feed to assure even distribution. Determine the appropriate amount of Stafac 50 required from the table below. Dilute Stafac 50 with a portion of one of the feed ingredients (enough to make a quantity equal to 10 lb per ton) before final mixing. Swine Required level of virginiamycin activity per ton of Type C Medicated Feed (complete feed) Required amount of Stafac 50 per ton of Type C Medicated Feed (complete feed) Amount of virginiamycin activity provided to animal per lb of body weight per day Treatment of swine dysentery in nonbreeding swine weighing over 120 lb 100 g for 2 weeks 2 lb 2.27 mg Treatment and control of swine dysentery in swine weighing up to 120 lb 100 g for 2 weeks followed by 50 g 2 lb 1 lb 2.27 mg 1.14 mg Aid in control of swine dysentery in swine weighing up to 120 lb For use in animals or on premises with a history of swine dysentery but where symptoms have not yet occurred 25 g 8 oz 0.57 mg CAUTION: Not for use in breeding swine over 120 lbs. Mixing Directions—Poultry Mix 1 lb of Stafac 50 with 9 lb of feed ingredients to make 10 lb of an intermediate mix to contain 5 g/lb virginiamycin. Add 1 lb of the intermediate feed premix for each 5 g of virginiamycin needed to medicate a ton of feed. Poultry Required level of virginiamycin activity per ton of Type C Medicated Feed (complete feed) Required amount of Stafac 50 per ton of Type C Medicated Feed (complete feed) For use in broiler chickens Prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin 20 g 180 g Not for Use in Laying Chickens

    ORAL

    Stafac® 50 (virginiamycin) TYPE A MEDICATED ARTICLE

  • Mixing Directions Stafac 20 Type A Medicated Article must be thoroughly mixed in the feed to assure even distribution. Determine the appropriate amount of Stafac 20 required from the table below. Dilute Stafac 20 with a portion of one of the feed ingredients (enough to make a quantity equal to 10 lb per ton) before final mixing. Swine Required level of virginiamycin activity per ton of Type C Medicated Feed (complete feed) Required amount of Stafac 20 per ton of Type C Medicated Feed (complete feed) Amount of virginiamycin activity provided to animal per lb of body weight per day Treatment of swine dysentery in nonbreeding swine weighing over 120 lb 100 g for 2 weeks 5.00 lb 2.27 mg Treatment and control of swine dysentery in swine weighing up to 120 lb 100 g for 2 weeks followed by 50g 5.00 lb 2.50 lb 2.27 mg 1.14 mg Aid in control of swine dysentery in swine weighing up to 120 lb For use in animals or on premises with a history of swine dysentery but where symptoms have not yet occurred 25 g 1.25 lb 0.57 mg CAUTION: Not for use in breeding swine over 120 lbs. Poultry Required level of virginiamycin activity per ton of Type C Medicated Feed (complete feed) Required amount of Stafac 20 per ton of Type C Medicated Feed (complete feed) Prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin Not for Use in Laying Chickens 20 g 1.00 lb Feed Continuously as Sole Ration

    ORAL

    Stafac® 20 (virginiamycin) TYPE A MEDICATED ARTICLE

  • Type B Medicated Feeds for cattle fed in confinement for slaughter—Thoroughly mix the following amounts of V-Max Type A Medicated Article to make 1 ton of Type B Medicated Feed to provide the concentrations shown in Table 1. An intermediate blending step, consistent with the mixing equipment specifications, should be performed to ensure adequate mixing. Table 1. Type B Medicated Feed lb of V-Max Type A Medicated Article per ton of supplement Virginiamycin concentration in Type B Medicated Feed (g/ton) 1.1 2.2 4.4 8.8 22.0 44.0 250 500 1,000 2,000 5,000 10,000 Type C Medicated Feed The Type B Medicated Feed must be diluted to a Type C Medicated Feed before being fed. Prepare a Type B Medicated Feed as described above. Thoroughly mix the V-Max Type B Medicated Feed to make 1 ton of Type C Medicated Feed to provide 13.5 – 16.0 g of virginiamycin per ton of complete feed on a 90% dry matter basis using the examples provided in Table 2. Table 2. Type C Medicated Feed lb of a 500g/ton Type B Medicated Feed per ton of complete feed lb of a 1,000 g/ton Type B Medicated Feed per ton of complete feed lb of a 5,000 g/ton Type B Medicated Feed per ton of complete feed lb of a 10,000 g/ton Type B Medicated Feed per ton of complete feed Virginiamycin concentration in complete feed 90% dry matter basis (g/ton) 54 27 5.4 2.7 13.5 64 32 6.4 3.2 16.0

    ORAL

    V-MaxTM (Virginiamycin) TYPE A MEDICATED ARTICLE

  • Cattle fed in confinement for slaughter Virginiamycin required mg/hd/day Virginiamycin (g/tons) of complete feed (90% dry matter basis) Reduction of incidence of liver abscesses 85-240 13.5-16.0 Caution: Not for use in animals intended for breeding. Mixing Directions Type B medicated feed for cattle fed in confinement for slaughter - Thoroughly mix 4.4 lb of HepafleX Type A Medicated Article per ton of Type B medicated feed to provide 1000 g/ton virginiamycin. An intermediate blending step, consistent with the mixing equipment specifications, should be performed to ensure adequate mixing. Type C medicated feed The Type B medicated feed must be diluted to a Type C medicated feed before being fed. Prepare a Type B medicated feed as described above. Thoroughly mix the Type B medicated feed to make 1 ton of Type C medicated feed to provide 13.5–16.0g of virginiamycin per ton of complete feed on a 90% dry matter basis using the examples provided in Table 1. Table 1. Type C medicated feed lb of a 1,000 g/ton Type B medicated feed per ton of complete feed Virginiamycin concentration in complete feed 90% dry matter basis (g/ton) 27 13.5 32 16.0 Feed continuously as sole ration

    ORAL

    HepafleXTM (virginiamycin) Type A Medicated Article

  • Cattle fed in confinement for slaughter Virginiamycin required mg/hd/day Virginiamycin (g/tons) of complete feed (90% dry matter basis) Reduction of incidence of liver abscesses 85–240 13.5–16.0 Caution: Not for use in animals intended for breeding.

    ORAL

    V-MaxTM (Virginiamycin) TYPE A MEDICATED ARTICLE

Available strengths (40)

ProductDosage formAvailable strengths
Avatec® / Stafac®Medicated FeedLasalocid: Type A medicated article in a concentration of 90.7 grams lasalocid activity per pound. Virginiamycin: Type A medicated article in concentrations of 20 and 227 grams of virginiamycin activity per pound.
Clinacox™ / Stafac®Medicated FeedDiclazuril is supplied as a Type A medicated article in a concentration of 0.91 grams diclazuril activity per pound. Virginiamycin is supplied as a Type A medicated article in concentrations of 5, 10, 20, 50, or 227 grams of virginiamycin activity per pound.
Clinacox™ / Stafac®Medicated FeedDiclazuril is supplied as a Type A medicated article in a concentration of 0.91 grams diclazuril activity per pound. Virginiamycin is supplied as a Type A medicated article in concentrations of 5, 10, 20, 50, or 227 grams of virginiamycin activity per pound.
V-Max®Type A Medicated ArticleType A medicated articles containing 50 or 227 grams virginiamycin per pound.
V-Max® 50Type A Medicated ArticleType A medicated articles containing 50 or 227 grams virginiamycin per pound
Coban® / Stafac®Medicated FeedMonensin is supplied as a Type A medicated article in a single concentration of 60 grams of monensin activity per pound. Virginiamycin is supplied as Type A medicated articles in concentrations of 20 and 227 grams of virginiamycin activity per pound.
Stafac® 500Type A Medicated ArticleType A medicated articles containing 10, 20, 50, or 227 grams virginiamycin per pound
Stafac® 500Type A Medicated ArticleType A medicated articles containing 10, 20, 50, or 227 grams virginiamycin per pound
Stafac® 500Type A Medicated ArticleType A medicated articles containing 10, 20, 50, or 227 grams virginiamycin per pound
Stafac® 10Type A Medicated ArticleType A medicated articles containing 10, 20, 50, or 227 grams virginiamycin per pound
Stafac® 20Type A Medicated ArticleType A medicated articles containing 10, 20, 50, or 227 grams virginiamycin per pound
Stafac®Medicated Feed50 g virginiamycin activity per lb
Stafac®Medicated Feed50 g virginiamycin activity per lb
Stafac®Medicated Feed50 g virginiamycin activity per lb
Stafac®Medicated Feed50 g virginiamycin activity per lb
Avatec® / Stafac®Medicated FeedType A medicated articles approved for 15 percent activity.
Amprol HI-E® / Stafac®Medicated FeedType A medicated articles: 25 percent amprolium and 8 percent ethopabate;
Stafac® 10Medicated FeedType A medicated articles: 1.1 percent activity (5 grams per pound); 2.2 percent activity (10 grams per pound).
Stafac® 10Medicated FeedType A medicated articles: 1.1 percent activity (5 grams per pound); 2.2 percent activity (10 grams per pound).
Virginiamycin Type A Medicated ArticleMedicated FeedType A medicated articles: 1.1 percent activity (5 grams per pound); 2.2 percent activity (10 grams per pound). Dilute Type A article with at least 10 pounds of a feed ingredient prior to final mixing in 1 ton of Type C feed.
Virginiamycin Type A Medicated ArticleMedicated FeedType A medicated articles: 1.1 percent activity (5 grams per pound); 2.2 percent activity (10 grams per pound). Dilute Type A article with at least 10 pounds of a feed ingredient prior to final mixing in 1 ton of Type C feed.
Stafac® Swine Pak 10 gMedicated FeedType A medicated articles: 1.1 percent activity (5 grams per pounds); 2.2 percent activity (10 grams per pound). Dilute Type A article with at least 10 pounds of a feed ingredient prior to final mixing in 1 ton of Type C feed.
Stafac® Swine Pak 10 gMedicated FeedType A medicated articles: 1.1 percent activity (5 grams per pounds); 2.2 percent activity (10 grams per pound). Dilute Type A article with at least 10 pounds of a feed ingredient prior to final mixing in 1 ton of Type C feed.
Aviax® and Stafac®Type A Medicated ArticleType A medicated articles containing 22.7 grams per pound semduramicin sodium. Type A medicated articles containing 10, 20, 50, or 227 grams per pound virginiamycin.
3-Nitro® / Stafac® / Coban®Medicated FeedMonensin as the base or the sodium salt, contains a minimum of 90 percent monensin activity derived from monensin A and a minimum of 95 percent derived from monensin A plus B. Approvals for Type A medicated articles containing 45 and 60 grams per pound, as monensin sodium.
Aviax II® plus Stafac®Type A Medicated ArticleType A medicated articles containing semduramicin sodium biomass (22.7 g/lb) and virginiamycin (20 g/lb, 50 g/lb, or 227 g/lb)
Stafac® and Coban™Type A Medicated ArticleVirginiamycin (20 g per ton of feed) to be supplied by: 20, 50, or 227 g/lb Type A medicated article Monensin (90 to 110 g per ton of feed) to be supplied by: 90 g/lb Type A medicated article
Coban® / Stafac®Medicated FeedApprovals for Type A medicated articles containing: 45 and 60 grams per pound.
Stafac® and Bio-Cox®Type A Medicated ArticleVirginiamycin: 20, 50, or 227 g/lb virginiamycin. Salinomycin sodium: 30 or 60 g/lb salinomycin.
Clinacox® and Stafac®Type A Medicated ArticleDiclazuril: 0.2% diclazuril. Virginiamycin: 10, 20, 50, or 227 g/lb. virginiamycin
Stafac® and AMPROL®Type A Medicated ArticleVirginiamycin: 10, 20, 50, or 227 g/lb. Amprolium: 25% amprolium
Stafac® and Avatec®Type A Medicated ArticleVirginiamycin: 10, 20, 50, or 227 g/lb. virginiamycin. Lasalocid sodium: 90.7 g/lb. lasalocid sodium
Stafac® and Monteban™Type A medicated articles to be used in the manufacture of Type C medicated feedsStafac®: 20, 50, or 227 g/lb of virginiamycin; Monteban™: 45 g/lb of narasin
Stafac® and Maxiban™Type A medicated articles to be used in the manufacture of Type C medicated feedsStafac®: 20, 50, or 227 g/lb of virginiamycin; Maxiban™: 36 g/lb narasin and 36 g/lb nicarbazin
Rumensin™ and V-Max®Type A medicated articles for use in the manufacture of Type B and Type C medicated feedsRumensin™: 90.7 g/lb of monensin USP; V-Max®: 50 g/lb and 227 g/lb of virginiamycin
Experior™ and Rumensin™ and V-Max®Type A medicated articles for use in the manufacture of Type B and Type C medicated feedsExperior™: 10 g/kg (4.54 g/lb) and 50 g/kg (22.7 g/lb) of lubabegron (as lubabegron fumarate); Rumensin™: 90.7 g/lb of monensin USP; V-Max®: 50 g/lb and 227 g/lb of virginiamycin
Optaflexx™ and Rumensin™ and V-Max®Type A medicated articles for use in the manufacture of Type B and Type C medicated feedsOptaflexx™: 45.4 g/lb of ractopamine hydrochloride; Rumensin™: 90.7 g/lb of monensin USP; V-Max®: 50 g/lb and 227 g/lb of virginiamycin
——20 g / 0.45 kg
——227 g / 0.45 kg
——50 g / 0.45 kg