تايلوزين

Growing beef steers and heifers on pasture (stocker, feeder, and slaughter)

For increased rate of weight gain in growing beef steers and heifers on pasture (stocker, feeder, and slaughter). Not approved for repeated implantation (reimplantation) with this or any other cattle ear implant in growing beef steers and heifers on pasture (stocker, feeder, and slaughter). Safety and effectiveness following reimplantation have not been evaluated.

Component™ TE-G with Tylan™

Growing beef steers and heifers on pasture (stocker, feeder, and slaughter)

For increased rate of weight gain. Not approved for repeated implantation (reimplantation) with this or any other cattle ear implant in growing beef steers and heifers on pasture (stocker, feeder, and slaughter). Safety and effectiveness following reimplantation have not been evaluated.

Implant subcutaneously in ear only. Do not use in animals intended for subsequent breeding or in dairy animals. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component™ TE-G

Cattle (steers fed in confinement for slaughter excluding veal)

For increased rate of weight gain and improved feed efficiency.

Implant subcutaneously in ear only. Do not use in animals intended for subsequent breeding or in dairy animals. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component™ TE-IS

Cattle (slaughter, stocker, feeder steers, and heifers)

For increased rate of weight gain.

Implant subcutaneously in ear only. Do not use in animals intended for subsequent breeding or in dairy animals. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component™ TE-IS

Growing beef steers fed in confinement for slaughter

For increased rate of weight gain and improved feed efficiency in growing beef steers fed in confinement for slaughter. Not approved for repeated implantation (reimplantation) with this or any other cattle ear implant in growing beef steers fed in confinement for slaughter. Safety and effectiveness following reimplantation have not been evaluated.

Component™ TE-IS with Tylan™

Cattle (heifers fed in confinement for slaughter)

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, prevention and control of coccidiosis due to Eimeria bovis and E. zuernii and reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes, and for suppression of estrus (heat) in heifers fed in confinement for slaughter for the last 28 to 42 days on feed.

Melengestrol acetate is not effective in steers and spayed heifers. Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at time of loading. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Ractopamine HCl is not for animals intended for breeding.Special considerations:Mixing directions for liquid melengestrol acetate Type C feeds stored in recirculation tank systems, labeling indicates: “Recirculate immediately prior to use for no less than 10 minutes, moving not less than 1 percent of the tank contents from the bottom of the tank to the top. Recirculate daily, as directed in this paragraph even when the Type C feed is not used.” For liquid melengestrol Type C feeds stored in mechanical, air or other agitation-type tank systems: “Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily, as directed in this paragraph, even when the Type C feed is not used.”

Optaflexx™ and Rumensin™ and Tylan™and MGA®

Cattle (heifers fed in confinement for slaughter)

Increased rate of weight gain, improved feed efficiency, suppression of estrus (heat), prevention and control of coccidiosis due to Eimeria bovis and Eimeria zuernii, reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium pyogenes in heifers fed in confinement for slaughter.

Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Feed continuously as sole ration to heifers at a rate of 0.5 to 2.0 pounds per head per day to provide 0.25 to 0.5 mg/head/day melengestrol acetate and 0.14 to 0.42 mg monensin/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/head/day and 60 to 90 mg/head/day tylosin. The melengestrol acetate portion of this Type C medicated feed must be mixed into the complete feed containing 10 to 40 g/ton monensin and 8 to 10 g/ton tylosin at feeding into the amount of complete feed consumed by an animal per day. Melengestrol acetate is for use only in heifers being fed in confinement for slaughter. Not effective in steers or spayed heifers. Heifers fed in confinement for slaughter: Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at the time of loading. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle and goat feed is safe for use in cattle and goats only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

HeifermaX™ 500 / Rumensin™ / Tylan™

Cattle (heifers fed in confinement for slaughter)

For increased rate of weight gain, improved feed efficiency, suppression of estrus (heat), for the prevention and control of coccidiosis due to Eimeria bovis and Eimeria zuernii; and for reduced incidence of liver abscesses caused by Fusobacterium necrophorum and Actinomyces (Corynebacterium) pyogenes.

For heifers fed in confinement for slaughter.

MGA® 100 / Rumensin® / Tylan®

Cattle (heifers fed in confinement for slaughter)

For increased rate of weight gain and improved feed efficiency.

Implant subcutaneously in ear only. Do not use in animals intended for subsequent breeding or in dairy animals. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component® T-H with Tylan®

Cattle (heifers)

For increased rate of weight gain, improved feed efficiency, suppression of estrus (heat), and for reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterium pyogenes in heifers fed in confinement for slaughter.

When tylosin is fed in combination with melengestrol acetate and lasalocid, the level of tylosin is limited to 90 mg/hd/day. For use only in heifers being fed in confinement for slaughter. Not effective in steers and spayed heifers. This combination may only be marketed as a pelleted product. Do not allow horses or other equines access to premixes or supplements containing lasalocid, as ingestion may be fatal. The safety of lasalocid in unapproved species has not been established. Mixing errors resulting in excessive concentrations of lasalocid could be fatal to cattle and sheep. When mixing and handling lasalocid, use protective clothing, impervious gloves and a dust mask, avoid contact with eyes. Operators should wash hands thoroughly with soap and water after handling. Use melengestrol acetate only as directed.

MGA® and Bovatec® and Tylan™

Cattle (heifers)

For increased rate of weight gain, improved feed efficiency, suppression of estrus (heat), and reduced incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterium pyogenes.

Feed continuously as sole ration. MGA is for use only in heifers being fed in confinement for slaughter. Not effective in steers and spayed heifers. When mixing and handling tylosin, use protective clothing, impervious gloves and a dust mask. Operators should wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Heifermax™ 500 Liquid Premix and Tylan®

Cattle (heifers)

For increased rate of weight gain, improved feed efficiency, and suppression of estrus (heat) in heifers fed in confinement for slaughter.

When tylosin is fed in combination with melengestrol acetate and lasalocid, the level of tylosin is limited to 90 mg/hd/day. Melengestrol acetate is only for use in heifers being fed in confinement for slaughter. Not effective in steers and spayed heifers. This combination may only be marketed as a pelleted product. Do not allow horses or other equines access to premixes or supplements containing lasalocid, as ingestion may be fatal. The safety of lasalocid in unapproved species has not been established. Mixing errors resulting in excessive lasalocid concentrations could be fatal to cattle and sheep. When mixing and handling lasalocid, use protective clothing, impervious gloves and a dust mask, avoid contact with eyes. Operators should wash hands thoroughly with soap and water after handling. Use melengestrol acetate only as directed.

MGA® and Bovatec® and Tylan™

Cattle (fed in confinement for slaughter)

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, prevention and control of coccidiosis due to Eimeria bovis and E. zuernii, and reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes in cattle fed in confinement for slaughter for the last 20 to 40 days on feed.

Feed continuously during the last 20 to 40 days on feed. Do not allow horses or other equines access to feed containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.Zilpaterol hydrochloride is not for use in animals intended for breeding. Do not allow horses or other equines access to feed containing zilpaterol. Do not use in veal calves. Animals receiving zilpaterol hydrochloride may exhibit increased respiratory rate aswell as elevated levels of creatine phosphokinase (CPK) and creatine.Special considerations:1) Labeling for Type B feeds used to manufacture Type C complete feeds must bear the caution statement: Not to be fed to cattle in excess of 90 mg/head/day in complete feed. If pen consumption of complete feed exceeds 26.5 lb/head/day (90 percent dry matter basis), zilpaterol should not be fed in complete feed. 2) Type B Liquid Feeds can be manufactured containing 68 to 680 g zilpaterol hydrochloride/ton. Inadequate mixing (recirculation or agitation) of monensin liquid Type B or Type C medicated feeds has resulted in increased monensin concentration, which has been fatal to cattle. For liquid feeds stored in recirculating tank systems: Recirculate immediately prior to use for not less than 10 minutes, moving not less than 1 percent of the tank contents per minute from the bottom of the tank to the top. Recirculate daily as described even when not used. For liquid feeds stored in mechanical, air or other agitation-type tank systems: Agitate immediately prior to use for not less than 10 minutes, creating turbulence at the bottom of the tank that is visible at the top. Agitate daily as described even when not used.3) All labeling for Type B and Type C feeds provides the warning: The active ingredient in Zilmax® is zilpaterol hydrochloride, a beta2-adrenergic agonist. Not for use in humans. An anti-dust process has been applied to the drug product, Zilmax®, in order to greatly reduce inhalation risk. Extended handling tasks with the potential for dust generation require respiratory protection. Wear appropriate skin protection (e.g., impervious gloves, apron, overalls), if there is a potential for extended skin contact. Wear protective eyewear, if there is a potential for eye contact. If accidental eye contact occurs, immediately rinse with water and consult a physician.

Zilmax® and Rumensin™ and Tylan™

Cattle fed in confinement for slaughter

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, prevention and control of coccidiosis due to Eimeria bovis and E. zuernii, and reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes in cattle fed in confinement for slaughter for the last 28 to 42 days on feed.

Feed continuously as sole ration to provide 90 to 430 mg ractopamine per hd/day and 0.14 to 0.42 mg monensin per lb body weight/day (depending on severity of coccidiosis challenge, up to 480 mg/hd/day), and 60 to 90 mg tylosin per hd/day for the last 28 to 42 days on feed. Labeling: The labeling of dry Type B feeds containing ractopamine, monensin, and tylosin intended for use in cattle shall bear the following caution statements: Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Ractopamine HCl is not for animals intended for breeding. The labeling of liquid Type B feeds containing ractopamine, monensin and tylosin intended for use in cattle shall bear the following caution statements: Inadequate mixing (recirculation or agitation) of monensin liquid Type B medicated feed has resulted in increased monensin concentration, which has been fatal to cattle. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Feeding undiluted or mixing errors resulting in high concentrations of monensin has been fatal to cattle. Must be thoroughly mixed in feeds before use. Do not feed undiluted. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any liquid feed containing sodium metabisulfite or in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Expiration Date: 31 days after the date of manufacture. Ractopamine HCl is not for animals intended for breeding. The labeling of all Type C feeds containing ractopamine, monensin, and tylosin intended for use in cattle shall bear the following caution statements: Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Ractopamine HCl is not for animals intended for breeding.

Optaflexx™ and Rumensin™ and Tylan™

Cattle fed in confinement for slaughter

For improved feed efficiency, prevention and control of coccidiosis due to Eimeria bovis and E. zuernii, and reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes in cattle being fed in confinement for slaughter.

Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Rumensin® plus Tylovet® 100

Cattle fed in confinement for slaughter

For prevention and control of coccidiosis due to Eimeria bovis and E. zuernii, and reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes.

Rumensin™ and Tylan™

Cattle fed in confinement for slaughter

For improved feed efficiency and reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes in cattle fed in confinement for slaughter.

Monovet® and Tylovet®

Cattle fed in confinement for slaughter

For improved feed efficiency and reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes.

Feed only to cattle being fed in confinement for slaughter. Feed continuously as sole ration to provide 50 to 480 monensin mg/hd/day and 60 to 90 tylosin mg/hd/day. No additional improvement in feed efficiency has been shown from feeding monensin at levels greater than 30 g/ton (360 mg monensin per head per day).

Rumensin™ and Tylan™

Cattle fed in confinement for slaughter

For increased rate of weight gain and improved feed efficiency in cattle fed in confinement for slaughter during the last 28 to 42 days on feed.

Optaflexx™and Monovet® and Tylovet®

Cattle fed in confinement for slaughter

For reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes.

Optigrid® and Monovet® and Tylovet®

Cattle fed in confinement for slaughter

For improved feed efficiency and for the prevention and control of coccidiosis due to Eimeria bovis and E. zuernii.

Optigrid® and Monovet® and Tylovet®

Cattle fed in confinement for slaughter

For increased rate of weight gain, improved feed efficiency, and increased carcass leanness.

Optigrid® and Monovet® and Tylovet®

Cattle fed in confinement for slaughter

For increased rate of weight gain and improved feed efficiency.

Optigrid® and Monovet® and Tylovet®

Growing beef steers and heifers fed in confinement for slaughter

For increased rate of weight gain and improved feed efficiency in growing beef steers and heifers fed in confinement for slaughter. Not approved for repeated implantation (reimplantation) with this or any other cattle ear implant in growing beef steers and heifers fed in confinement for slaughter. Safety and effectiveness following reimplantation have not been evaluated.

Component™ TE-200 with Tylan™

Growing beef steers and heifers fed in confinement for slaughter

For the prevention of coccidiosis caused by Eimeria bovis and E. zuernii , for improved feed efficiency, and for reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterium pyogenes in growing beef steers and heifers fed in confinement for slaughter.

Deccox® and Rumensin™ and Tylovet®

Cattle (steers fed in confinement for slaughter)

For improved feed efficiency.

Implant subcutaneously in ear only. Do not use in animals intended for subsequent breeding or in dairy animals. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component® T-S with Tylan®

Cattle (beef)

For reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes.

Each animal must receive not more than 90 milligrams per day and not less than 60 milligrams per day. Feed continuously as sole ration.

Purina® Hog Plus II

Cattle (beef)

For reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterium pyogenes.

As tylosin phosphate. Each animal must receive not more than 90 mg/head/day and not less than 60 mg/head/day. Feed continuously as sole ration.

TYLAN™ 40

Beef Cattle

For reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Actinomyces (Corynebacterium) pyogenes.

As tylosin phosphate. Each animal must receive not more than 90 milligrams per day and not less than 60 milligrams per day. Feed continuously as sole ration.

Tylan® 100 Premix

Beef Cattle

For reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterioum pyogenes.

Tylovet® 100

Beef heifers fed in confinement for slaughter

For increased rate of weight gain, improved feed efficiency, suppression of estrus (heat), and reduced incidence of liver abscesses caused by Fusobacterium Necrophorum and Arcanobacterium (Actinomyces) pyogenes in heifers fed in confinement for slaughter.

Feed continuously as sole ration. Melengestrol acetate is for use only in heifers being fed in confinement for slaughter. Not effective in steers or spayed heifers. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

MGA® plus Tylovet® 100

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, prevention and control of coccidiosis due to Eimeria bovis and E. zuernii and reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes in cattle fed in confinement for slaughter for the last 28 to 42 days on feed.

Feed continuously as sole ration to provide 90 to 430 mg/hd/day ractopamine and 0.14 to 0.42 mg monensin/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/hd/day and 60 to 90 mg/hd/day tylosin for the last 28 to 42 days on feed.

Actogain® and Rumensin™ and Tylan™

For increased rate of weight gain, improved feed efficiency, suppression of estrus (heat), and for reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterium pyogenes in heifers fed in confinement for slaughter.

When tylosin is fed in combination with melengestrol acetate and lasalocid, the level of tylosin is limited to 90 mg/hd/day. For use only in heifers being fed in confinement for slaughter. Not effective in steers and spayed heifers. This combination may only be marketed as a pelleted product. Do not allow horses or other equines access to premixes or supplements containing lasalocid, as ingestion may be fatal. The safety of lasalocid in unapproved species has not been established. Mixing errors resulting in excessive concentrations of lasalocid could be fatal to cattle and sheep. When mixing and handling lasalocid, use protective clothing, impervious gloves and a dust mask, avoid contact with eyes. Operators should wash hands thoroughly with soap and water after handling. Use melengestrol acetate only as directed.

MGA®/ Bovatec®/ Tylovet® 100

For increased rate of weight gain, improved feed efficiency, and suppression of estrus (heat) in heifers fed in confinement for slaughter.

When tylosin is fed in combination with melengestrol acetate and lasalocid, the level of tylosin is limited to 90 mg/hd/day. Melengestrol acetate is only for use in heifers being fed in confinement for slaughter. Not effective in steers and spayed heifers. This combination may only be marketed as a pelleted product. Do not allow horses or other equines access to premixes or supplements containing lasalocid, as ingestion may be fatal. The safety of lasalocid in unapproved species has not been established. Mixing errors resulting in excessive lasalocid concentrations could be fatal to cattle and sheep. When mixing and handling lasalocid, use protective clothing, impervious gloves and a dust mask, avoid contact with eyes. Operators should wash hands thoroughly with soap and water after handling. Use melengestrol acetate only as directed.

MGA®/ Bovatec®/ Tylovet® 100

Cattle (Beef)

For reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Actinomyces (Corynebacterium) pyogenes.

As tylosin phosphate. Each animal must receive not more than 90 milligrams per day and not less than 60 milligrams per day. Feed continuously as sole ration.

Tylan® 5 Premix

Heifers fed in confinement for slaughter

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, prevention and control of coccidiosis due to Eimeria bovis and E. zuernii and reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes, and for suppression of estrus (heat) in heifers fed in confinement for slaughter for the last 28 to 42 days on feed.

Optigrid® and Monovet® and Tylovet® and CycleGuard®

Heifers fed in confinement for slaughter

For increased rate of weight gain, improved feed efficiency, suppression of estrus (heat), prevention and control of coccidiosis due to Eimeria bovis and Eimeria zuernii, reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium pyogenes in heifers fed in confinement for slaughter.

CycleGuard® and Monovet® and Tylovet®

Heifers fed in confinement for slaughter

For reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes.

Optigrid® and Monovet® and Tylovet® and MGA®

Heifers fed in confinement for slaughter

For improved feed efficiency and for the prevention and control of coccidiosis due to Eimeria bovis and E.zuernii.

Optigrid® and Monovet® and Tylovet® and MGA®

Heifers fed in confinement for slaughter

For increased rate of weight gain, improved feed efficiency and suppression of estrus (heat).

Optaflexx™ and Monovet® and Tylovet® and MGA®

Heifers fed in confinement for slaughter

For increased rate of weight gain, improved feed efficiency, and increased carcass leanness.

Optigrid® and Monovet® and Tylovet® and MGA®

Heifers fed in confinement for slaughter

For increased rate of weight gain and improved feed efficiency.

Implant subcutaneously in ear only. Do not use in animals intended for subsequent breeding or in dairy animals. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component™ TE-H with Tylan™

Growing beef heifers fed in confinement for slaughter

For increased rate of weight gain, improved feed efficiency, suppression of estrus (heat), for reduction of ammonia gas emissions per pound of live weight and hot carcass weight, and for the prevention and control of coccidiosis caused by Eimeria bovis and Eimeria zuernii, and for reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterium pyogenes in growing beef heifers fed in confinement for slaughter during the last 14 to 91 days on feed.

MGA® and Experior™ and Monovet® and Tylovet®

Growing beef heifers fed in confinement for slaughter

For increased rate of weight gain and improved feed efficiency in growing beef heifers fed in confinement for slaughter. Not approved for repeated implantation (reimplantation) with this or any other cattle ear implant in growing beef heifers fed in confinement for slaughter. Safety and effectiveness following reimplantation have not been evaluated.

Component™ TE-IH with Tylan™

Cattle (heifers fed in confinement for slaughter

Increased rate of weight gain, improved feed efficiency, suppression of estrus (heat), prevention and control of coccidiosis due to Eimeria bovis and Eimeria zuernii, reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium pyogenes in heifers fed in confinement for slaughter.

Feed continuously as sole ration to heifers at a rate of 0.5 to 2.0 pounds per head per day to provide 0.25 to 0.5 mg/head/day melengestrol acetate and 0.14 to 0.42 mg monensin/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/head/day and 60 to 90 mg/head/day tylosin. The melengestrol acetate portion of this Type C medicatedfeed must be mixed into the complete feed containing 10 to 40 g/ton monensin and 8 to 10 g/ton tylosin at feeding into the amount of complete feed consumed by an animal per day.Melengestrol acetate is for use only in heifers being fed in confinement for slaughter. Not effective in steers or spayed heifers. Heifers fed in confinement for slaughter: Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at the time of loading.Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle and goat feed is safe for use in cattle and goats only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing.Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

MGA® and Rumensin™ and Tylan™

Cattle (Beef and Non-lactating Dairy)

For use in the treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated with Pasteurella multocida and Arcanobacterium pyogenes; foot rot (necrotic pododermatitis) and calf diphtheria caused by Fusobacterium necrophorum and metritis caused by Arcanobacterium pyogenes.

Do not mix Tylan 200 Injection with other injectable solutions as this may cause a precipitation of the active ingredients. Adverse reactions, including shock and death may result from overdosage in baby pigs. Do not attempt injection into pigs weighing less than 25 pounds (0.5 mL) with the common syringe. It is recommended that Tylan 50 Injection be used in pigs weighing less than 25 pounds. Do not administer to horses or other equines. Injection of tylosin in equines has been fatal.

Tylan™ 200 Injection

Beef calves 45 days of age and older and weighing up to 400 lbs

For increased rate of weight gain in beef calves 45 days of age and older and weighing up to 400 lbs. This implant is not approved for repeated implantation (reimplantation) with this or any other cattle ear implant as safety and effectiveness has not been evaluated.

Component™ E-C with Tylan™

Cattle (suckling beef calves)

Increased rate of weight gain.

For use in suckling beef calves (at least 45 days of age) up to 400 pounds of body weight. For subcutaneous ear implantation, one dose per animal. Do not use in bull calves intended for reproduction. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component™ E-S with Tylan™

Growing beef steers weighing 400 lbs or more

For increased rate of weight gain and improved feed efficiency

Component™ E-S with Tylan™

Growing beef heifers weighing 400 lbs or more

For increased rate of weight gain and improved feed efficiency.

Component™ E-H with Tylan™

Cattle (Heifer)

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, prevention and control of coccidiosis due to Eimeria bovis and E. zuernii, reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes and suppression of estrus (heat) in heifers fed in confinement for slaughter for the last 20 to 40 days on feed.

Feed continuously as the sole ration for the final 20 to 40 days. Do not use in calves to be processed for veal. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feeds is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Zilpaterol hydrochloride is not for use in animals intended for breeding. Do not allow horses or other equines access to feed containing zilpaterol. Do not use in veal calves. Not to be fed to cattle in excess of 90 mg zilpaterol/head/day in complete feed. If pen consumption of complete feed exceeds 26.5 lb/head/day (90% dry matter basis), zilpaterol should not be fed in complete feed. Melengestrol acetate is not effective in steers and spayed heifers. Withdrawal periods of three to five days or more should be avoided to prevent the possibility that the heifers may come into estrus (heat) at loading time. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Special considerations: 1) For liquid melengestrol acetate Type C feeds stored in recirculation tank systems, labeling indicates: “Recirculate immediately prior to use for no less than 10 minutes, moving not less than 1 percent of the tank contents from the bottom of the tank to the top. Recirculate daily, as directed in this paragraph even when the Type C feed is not used.” For liquid melengestrol Type C feeds stored in mechanical, air or other agitation-type tank systems: “Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily, as directed in this paragraph, even when the Type C feed is not used.” 2) All labeling for Type C feeds containing zilpaterol hydrochloride provides the warning: The active ingredient in Zilmax® is zilpaterol hydrochloride, a beta2-adrenergic agonist. Not for use in humans. An anti-dust process has been applied to the drug product, Zilmax®, in order to greatly reduce inhalation risk. Extended handling tasks with the potential for dust generation require respiratory protection. Wear appropriate skin protection (e.g., impervious gloves, apron, overalls), if there is a potential for extended skin contact. Wear protective eyewear, if there is a potential for eye contact. If accidental eye contact occurs, immediately rinse with water and consult a physician.

Heifermax® 500/Zilmax®/Rumensin®/Tylan®

Beef cattle

For reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterioum pyogenes.

Tylovet® 40

Cattle, Beef, Heifers fed in confinement for slaughter

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, prevention and control of coccidiosis due to Eimeria bovis and E. zuernii and reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes, and for suppression of estrus (heat) in heifers fed in confinement for slaughter for the last 28 to 42 days on feed.

Melengestrol acetate is not effective in steers and spayed heifers. Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at time of loading. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Ractopamine HCl is not for animals intended for breeding. Special considerations: Mixing directions for liquid melengestrol acetate Type C feeds stored in recirculation tank systems, labeling indicates: “Recirculate immediately prior to use for no less than 10 minutes, moving not less than 1 percent of the tank contents from the bottom of the tank to the top. Recirculate daily, as directed in this paragraph even when the Type C feed is not used.” For liquid melengestrol Type C feeds stored in mechanical, air or other agitation-type tank systems: “Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily, as directed in this paragraph, even when the Type C feed is not used.”

Optaflexx™ 45/Rumensin®/Tylovet® 100/MGA®

Cattle, Beef, Heifers fed in confinement for slaughter

For increased rate of weight gain, improved feed efficiency, suppression of estrus (heat), prevention and control of coccidiosis due to Eimeria bovis and Eimeria zuernii, reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium pyogenes in heifers fed in confinement for slaughter

Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle and goat feed is safe for use in cattle and goats only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Feed only to cattle being fed in confinement for slaughter. Feed continuously as sole ration. A withdrawal time has not been established in pre-ruminating calves. Do not use in calves to be processed for veal.

MGA®, Rumensin™ and Tylovet® 100

Cattle, Beef heifers fed in confinement for slaughter

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, prevention and control of coccidiosis due to Eimeria bovis and E. zuernii, reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes and suppression of estrus (heat) in heifers fed in confinement for slaughter for the last 28 to 42 days on feed.

Feed continuously as sole ration during the last 28 to 42 days on feed. Not for animals intended for breeding. Do not use in calves to be processed for veal.Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Actogain™ 45/Rumensin®/Tylan®/MGA®

Cattle, Beef fed in confinement for slaughter

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, prevention and control of coccidiosis due to Eimeria bovis and E. zuernii and reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes in cattle fed in confinement for slaughter for the last 28 to 42 days on feed.

Feed a minimum of 1.0 lb/hd/day continuously to cattle fed in confinement for slaughter, to provide 70 to 400 mg/head/day ractopamine for the last 28 to 42 days on feed. Feed on top of a ration containing 10 to 40 g/ton monensin and 8 to 10 g/ton tylosin phosphate, to provide 0.14 to 0.42 mg monensin/lb body weight/day (depending on the severity of the coccidiosis challenge, up to 480 mg/hd/day), and 60 to 90 mg/hd/day tylosin. Ractopamine HCl is not for animals intended for breeding. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Optaflexx™ 45/Rumensin®/Tylovet® 100

Cattle (Heifers)

For increased rate of weight gain, improved feed efficiency, suppression of estrus (heat), and reduced incidence of liver abscesses.

For heifers being fed in confinement for slaughter.

Bovatec® / MGA® 100 / Tylan®

Cattle (beef and nonlactating dairy)

Treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated with Pasteurella multocida and Actinomyces pyogenes; foot rot (necrotic pododermatitis) and calf diphtheria caused by Fusobacterium necrophorum and metritis caused by Actinomyces pyogenes.

Treatment should be continued 24 hours after symptoms of the disease have stopped, not to exceed 5 days. Continue treatment 24 hours after symptoms disappear. Do not inject more than 10 milliliters per site. Do not use in lactating dairy cattle. Use a 50-milligram-per-milliliter solution for calves weighing less than 200 pounds. Do not administer within 21 days of slaughter. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Tylovet® 200 mg/mL Injection

Beef steers and heifers fed in confinement for slaughter

For reduction of ammonia gas emissions per pound of live weight and hot carcass weight, prevention and control of coccidiosis caused by Eimeria bovis and Eimeria zuernii, and reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterium pyogenes in beef steers and heifers fed in confinement for slaughter during the last 14 to 91 days on feed.

Experior™ and Rumensin™ and Tylan™

Beef steers and heifers fed in confinement for slaughter

For reduction of ammonia gas emissions per pound of live weight and hot carcass weight, improved feed efficiency, and reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterium pyogenes in beef steers and heifers fed in confinement for slaughter during the last 14 to 91 days on feed.

Experior™ and Rumensin™ and Tylan™

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, the treatment and control of swine dysentery associated with Brachyspira hyodysenteriae, and control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis immediately after medicating with tylosin in drinking water in finishing swine weighing at least 150 lbs and fed a complete ration containing at least 16% crude protein for the last 45 to 90 lbs of gain prior to slaughter. Not for use in swine intended for breeding.

Feed as the sole ration to finishing swine weighing at least 150 lbs for the last 45 to 90 lbs (group average) of weight gain prior to slaughter. Feed 40 to 100 grams of tylosin per ton of complete feed for 2 to 6 weeks immediately after medicating with tylosin in drinking water (250 mg tylosin per gallon) for 3 to 10 days. Ractopamine hydrochloride use may increase the number of injured, lame, and/or fatigued pigs during marketing. Behavioral signs such as hyperactivity, anxiety, and aggression have been reported in pigs fed ractopamine hydrochloride. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

Paylean™ and Tylan™

For reduction in the severity of effects of atrophic rhinitis; lowering the incidence and severity of Bordetella bronchiseptica rhinitis; prevention of swine dysentery associated with Brachyspira hyodysenteriae; control of swine pneumonias caused by bacterial pathogens (Pasteurella multocida and/or Arcanobacterium pyogenes); and reducing the incidence of cervical lymphadenitis (jowl abscesses) caused by Group E Streptococci. Only the sulfamethazine portion of this combination is active in controlling jowl abscesses.

Withdraw 15 days before swine are slaughtered.

Tylan™ 5 Sulfa-G™

For the treatment and control of swine dysentery associated with Brachyspira hyodysenteriae. For the treatment and control of swine dysentery associated with Brachyspira hyodysenteriae when followed immediately by tylosin phosphate Type A medicated article in feed. For the control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis when followed immediately by tylosin phosphate Type A medicated article in feed.

Only medicated water (250 mg tylosin per gallon) should be available while medicating with BiloVet. Swine must not be slaughtered for food within 48 hours after treatment.

BiloVet®

For the treatment and control of swine dysentery (SD) associated with Brachyspira hyodysenteriae. For the treatment and control of SD associated with Brachyspira hyodysenteriae when followed immediately by Tylovet Type A medicated article in feed. For the control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis when followed immediately by Tylovet Type A medicated article in feed.

Tylovet® Soluble

For the treatment and control of swine dysentery (SD) associated with Brachyspira hyodysenteriae. For the treatment and control of SD associated with Brachyspira hyodysenteriae when followed immediately by Tylan Type A medicated article in feed. For the control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis when followed immediately by Tylan Type A medicated article in feed.

Only medicated water should be available to swine while medicating with Tylan Soluble.

Tylan Soluble™

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, and control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis in finishing swine weighing at least 150 lbs and fed a complete ration containing at least 16% crude protein for the last 45 to 90 lbs of gain prior to slaughter. Not for use in swine intended for breeding.

Feed as the sole ration to finishing swine weighing at least 150 lbs for the last 45 to 90 lbs (group average) of weight gain prior to slaughter. Feed 100 g of tylosin per ton of complete feed for 21 days. Ractopamine hydrochloride use may increase the number of injured, lame, and/or fatigued pigs during marketing. Behavioral signs such as hyperactivity, anxiety, and aggression have been reported in pigs fed ractopamine hydrochloride. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

Paylean™ and Tylan™

Treatment of swine arthritis caused by Mycoplasma hyosynoviae; swine pneumonia caused by Pasteurella species; swine erysipelas caused by Erysipelothrix rhusiopathiae; acute swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae when followed by appropriate medication in the drinking water and/or feed.

Treatment should be continued 24 hours after symptoms of the disease have stopped, not to exceed 3 days. Continue treatment 24 hours after symptoms disappear. Do not inject more than 5 milliliters per site. Do not administer within 14 days of slaughter. If tylosin medicated drinking water is used as followup treatment for swine dysentery, the animal should thereafter receive feed containing 40 to 100 grams of tylosin per ton for 2 weeks to assure depletion of tissue residues.

Tylovet® 200 mg/mL Injection

For reduction in the severity of effects of atrophic rhinitis; lowering the incidence and severity of Bordetella bronchiseptica rhinitis; prevention of swine dysentery associated with Brachyspira hyodysenteriae; and control of swine pneumonias caused by bacterial pathogens (Pasteurella multocida and/or Arcanobacterium pyogenes).

Withdraw 15 days before swine are slaughtered. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Tylan® 10 Sulfa-G™

Indicated for use in the treatment of swine arthritis caused by Mycoplasma hyosynoviae; swine pneumonia caused by Pasteurella spp.; swine erysipelas caused by Erysipelothrix rhusiopathiae; swine dysentery associated with Treponema hyodysenteriae when followed by appropriate medication in the drinking water and/or feed.

Do not mix Tylan 200 Injection with other injectable solutions as this may cause a precipitation of the active ingredients. Adverse reactions, including shock and death may result from overdosage in baby pigs. Do not attempt injection into pigs weighing less than 25 pounds (0.5 mL) with the common syringe. It is recommended that Tylan 50 Injection be used in pigs weighing less than 25 pounds. Do not administer to horses or other equines. Injection of tylosin in equines has been fatal.

Tylan™ 200 Injection

Maintaining weight gains and feed efficiency in the presence of atrophic rhinitis; lowering the incidence and severity of Bordetella bronchiseptica rhinitis; prevention of swine dysentery (vibrionic); and control of swine pneumonias caused by bacterial pathogens (Pasteurella multocida and/or Corynebacterium pyogenes).

As tylosin phosphate. Withdraw 15 days before slaughter.

Mill Co Medicator TS-40 Premix

For treatment and control of swine dysentery (vibrionic); immediately after medicating with tylosin in drinking water; aid in the prevention of migration and establishment of large roundworm (Ascaris suum) infections; and as an aid in the prevention of establishment of nodular worm (Oesophagostomum) infections.

Feed 40 or 100 g of tylosin per ton of complete feed continuously as the sole ration for 2 to 6 weeks after treatment with tylosin in drinking water (250 mg tylosin per gallon) for 3 to 10 days. Do not use in any finished feed (supplement, concentrate or complete feed) containing bentonite. Withdraw 24 hours prior to slaughter.

Tylan™ and Banminth®

For prevention of swine dysentery (vibrionic); aid in the prevention of migration and establishment of large roundworms (Ascaris suum) infections; and as an aid in the prevention of establishment of nodular worm (Oesophagostomum) infections.

Feed continuously as the sole ration until market weight. This feed is for use following the feeding of 100 g per ton tylosin for at least 3 weeks. Do not use in any finished feed (supplement, concentrate or complete feed) containing bentonite. Withdraw 24 hours prior to slaughter.

Tylan™ and Banminth®

For the treatment and control of swine dysentery associated with Brachyspira hyodysenteriae, and for control of porcine proliferative enteropathies (ileitis) associated with Lawsonia intracellularis.

Administer as tylosin phosphate in feed for 2 to 6 weeks, immediately after treatment with tylosin tartrate in drinking water.

Purina® Hog Plus II

Control of infestations of large roundworms (Ascaris suis), nodular worms Oesophagostomum dentatum), and whipworms (Trichuris suis); growth promotion and feed efficiency.

As tylosin phosphate. Feed continuously.

Tylosin® / Hygromix

For the treatment and control of swine dysentery associated with Brachyspira hyodysenteriae immediately after medicating with Tylan Soluble (tylosin) drinking water.

Tylan® 40

For control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis.

Use 100 grams per ton for at least 3 weeks followed by 40 grams per ton until market weight. As tylosin phosphate.

TYLAN™ 20

Feed 100 g of tylosin per ton (2.5 pounds Tylan 40 per ton) of complete feed. Feed as the sole ration.

Tylan® 40

Maintaining weight gains and feed efficiency in the presence of atrophic rhinitis

As tylosin phosphate.

Vigorena Feeds Hy-Ty Premix

For treatment and control of swine dysentery associated with B. hyodysenteriae.

Administer as tylosin phosphate in feed for 2 to 6 weeks, immediately after treatment with tylosin tartrate in drinking water at 250 milligrams per gallon in drinking water for 3 to 10 days.

TYLAN™ 20

For control of swine dysentery associated with Brachyspira hyodysenteriae.

Use 100 grams per ton for at least 3 weeks followed by 40 grams per ton until market weight. As tylosin phosphate.

TYLAN™ 20

For control of porcine proliferative enteropathies (PPE, ileitis).

Tylovet® 40

For increased rate of weight gain and improved feed efficiency.

As tylosin phosphate. Continuous use.

Tylan® 10 Premix

For the reduction in severity of effects of atrophic rhinitis.

As tylosin phosphate.

TYLAN™ 20

As tylosin phosphate. Withdraw 15 days before slaughter.

Tylan® 5 Sulfa Premix

Treatment and control of swine dysentery (vibrionic).

Administer in feed as tylosin phosphate after treatment with tylosin in drinking water as tylosin base; 0.25 gram per gallon in drinking water for 3- 10 days, 40- 100 grams per ton in feed for 2- 6 weeks.

Tylan® 10 Premix

For the treatment and control of swine dysentery.

Tylovet® 40

Prevention of swine dysentery (vibrionic).

As tylosin phosphate.

Tylan® 10 Premix

Tylosin, 40-100 grams per ton of feed.

Administer in feed as tylosin phosphate after treatment with tylosin in drinking water as tylosin base; 0.25 grams per gallon in drinking water for 3-10 days, 40-100 grams per ton in feed for 2-6 weeks.

Vigorena Feeds Hy-Ty Premix

For control of swine dysentery.

Tylovet® 40

Finishing Swine

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, the treatment and control of swine dysentery associated with Brachyspira hyodysenteriae, and control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis immediately after medicating with tylosin in drinking water in finishing swine weighing at least 150 lbs and fed a complete ration containing at least 16% crude protein for the last 45 to 90 lbs of gain prior to slaughter. Not for use in swine intended for breeding.

Engain™ and Tylan™

Finishing Swine

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, and control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis in finishing swine weighing at least 150 lbs and fed a complete ration containing at least 16% crude protein for the last 45 to 90 lbs of gain prior to slaughter. Not for use in swine intended for breeding.

Engain™ and Tylan™

Broiler Chickens

For increased rate of weight gain and improved feed efficiency, and as an aid in the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati in broiler chickens.

For broiler chickens only. Do not feed to laying hens. Not approved for use with pellet binders. May be fatal if accidentally fed to adult turkeys or horses.

Tylan® / Bio-Cox®

Broiler Chickens

For the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati, and E. maxima, and for increased rate of weight gain and improved feed efficiency in broiler chickens.

For broiler chickens only. Feed continuously as sole ration. Do not allow adult turkeys, horses, or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal.

Monteban® / Tylan®

Broiler Chickens

As an aid in the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunette, E. mivati, and E. maxima, for increased rate of weight gain, and improved feed efficiency.

Feed continuously as sole ration. In the absence of coccidiosis, the use of monensin with no withdrawal period may limit feed intake resulting in reduced weight gain. Do not feed to laying chickens. Do not allow horses or other equines access to formulations containing monensin. Ingestion of monensin by equines has been fatal. Must be thoroughly mixed in feeds before use. Do not feed undiluted.

Coban® / Tylan®

Broiler Chickens

To aid in the control of chronic respiratory disease caused by Mycoplasma galisepticum.

Withdraw 5 days before slaughter.

Quali-Tech Tylan®-10 Premix

Chickens (broilers)

To aid in the control of chronic respiratory disease caused by Mycoplasma gallisepticum.

Withdraw 5 days before slaughter.

Purina® Hog Plus II

As an aid in the treatment of chronic respiratory disease (CRD) associated with Mycoplasma gallisepticum in broiler and replacement chickens. For the control of CRD associated with Mycoplasma gallisepticum at the time of vaccination or other stress in chickens. For the control of CRD associated with Mycoplasma synoviae in broiler chickens.

Tylovet® Soluble

Control of infestations of large roundworms (Ascaris galli) cecal worms (Heterakis gallinae,), and capillary worms (Capillaria obsignata); growth promotion and feed efficiency.

As tylosin phosphate.

Hygromix-Tylan® Premix

For the control of mortality caused by necrotic enteritis (NE) associated with Clostridium perfringens in broiler chickens.

Only medicated water should be available to the birds.

Tylan Soluble™

For increased rate of weight gain and improved feed efficiency.

As tylosin phosphate.

Tylan® 10 Premix

Tylosin, 4- 50 grams per ton of feed.

As tylosin phosphate.

Seeco Inc T-10 Premix

Chickens (laying)

For improved feed efficiency.

As tylosin phosphate.

Tylan® 10 Premix

Chickens (replacements)

Tylosin, 1,000 grams per ton of feed. Administer in feed to chickens 0 to 5 days of age, follow with second administration in feed for 24 to 48 hours at 3 to 5 weeks of age.

As tylosin phosphate. Withdraw 5 days before slaughter.

Seeco Inc T-10 Premix

Chickens (replacements)

To aid in the control of chronic respiratory disease caused by Mycoplasma gallisepticum.

Purina® Hog Plus II

Chickens (Replacements)

To aid in the control of chronic respiratory disease caused by Mycoplasma gallisepticum.

As tylosin phosphate. Withdraw 5 days before slaughter.

Tylan® 5 Premix

Chickens (Broilers)

To aid in the control of chronic respiratory disease caused by Mycoplasma gallisepticum.

As tylosin phosphate. Withdraw 5 days before slaughter.'

Tylan® 5 Premix

Chickens (Layers)

For improved feed efficiency.

As tylosin phosphate.

Hy-Con Tylan® Premix

Replacement Chickens

To aid in the control of chronic respiratory disease caused by Mycoplasma galisepticum.

Withdraw 5 days before slaughter.

Quali-Tech Tylan®-10 Premix

Laying Chickens

For improved feed efficiency.

As tylosin phosphate.

Tylan® 10 Premix

Chickens (Laying)

For improved feed efficiency.

As tylosin phosphate.

Tylan® 5 Premix

Chickens (broiler)

To aid in the control of chronic respiratory disease caused by Mycoplasma

As tylosin phosphate. Withdraw 5 days before slaughter.

McNess Custom Premix L200

Broiler and replacement chickens

As an aid in the treatment of chronic respiratory disease (CRD) associated with Mycoplasma gallisepticum sensitive to tylosin in broiler and replacement chickens. For the control of CRD associated with Mycoplasma gallisepticum sensitive to tylosin at the time of vaccination or other stress in chickens. For the control of CRD associated with Mycoplasma synoviae sensitive to tylosin in broiler chickens.

Only medicated water should be available to birds. Chickens must not be slaughtered for food within 24 hours after treatment. Do not use in layers producing eggs for human consumption.

BiloVet®

Broiler chickens

For the control of mortality caused by necrotic enteritis (NE) associated with Clostridium perfringens in broiler chickens.

BiloVet®

Honey Bees

For the control of American Foulbrood (Paenibacillus larvae).

Tylan Soluble™

For the control of American Foulbrood (Paenibacillus larvae).

Tylovet® Soluble

For the reduction in severity of effects of infectious sinusitis associated with Mycoplasma gallisepticum.

Only medicated water should be available to the birds.

Tylan Soluble™

Please see NADA 139-192 for more information.

Please see NADA 139-192 for more information.

MGA® and Tylan™

Tylovet®100 Tylosin Phosphate Directions for Use Read All Directions Carefully Before Mixing and Feeding Tylovet® 100 Type A Medicated Article Net Weight: 50 lbs Do Not Feed Undiluted. (22.68 kg) CAUTION: Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Active Drug Ingredient: Tylosin (as tylosin phosphate)...100 g per lb Ingredients: Roughage products, pregelatanized starch and dipotassium phosphate. Caution: To ensure adequate mixing, an intermediate blending step should be used prior to manufacturing a complete feed. Do not use in any liquid feed containing sodium metabisulfite or in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Warning: Tylovet 100 may be irritating to unprotected skin and eyes. When mixing and handling Tylovet 100 use protective clothing, impervious gloves and a dust respirator. In case of accidental exposure, flush eyes with plenty of water. Exposed skin should be washed with plenty of soap and water. Remove and wash contaminated clothing. Seek medical attention if irritation becomes severe or persists. The safety data sheet (SDS) contains more detailed occupational safety information. To report adverse effects, access medical information, or obtain additional product information, call 1-877-994-4883. For the reduction in severity of effects of atrophic rhinitis. Feed 100 g of tylosin per ton (1.0 pound Tylovet 100 per ton) of complete feed. Feed continuously as the sole ration. For control of swine dysentery. Feed 100 g of tylosin per ton (1.0 pound Tylovet 100 per ton) of complete feed for at least three weeks. Follow with 40 g tylosin per ton (0.4 pounds Tylovet 100 per ton) of complete feed until pigs reach market weight. For the treatment and control of swine dysentery. Feed 40 to 100 grams of tylosin (0.4 to 1.0 pounds of Tylovet 100) per ton of complete feed for 2 to 6 weeks immediately after medicating with 250 mg tylosin (as Tylosin Soluble) per gallon in drinking water for 3 to 10 days. For the control of porcine proliferative enteropathies (PPE, ileitis). Feed 100 g tylosin per ton (1.0 pound Tylovet 100 per ton) of complete feed for 21 days. Alternatively, feed 100 g of tylosin per ton (1.0 pound Tylovet 100 per ton) of complete feed for at least three weeks, followed by 40 g tylosin per ton of complete feed until pigs reach market weight. Alternatively, feed 40 to 100 grams of tylosin (0.4 to 1.0 pounds of Tylovet 100) per ton of complete feed for 2 to 6 weeks immediately after medicating with 250 mg tylosin (as Tylovet Soluble) per gallon in drinking water for 3 to 10 days. Feed continuously as the sole ration when feeding Tylovet. NOTICE: Organisms vary in their degree of susceptibility to any chemotherapeutic. If no improvement is observed after recommended treatment, diagnosis and susceptibility should be reconfirmed. Mixing and Feeding Directions for Beef Cattle Feeds For reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterium pyogenes Tylovet 100 per Ton of Type C Feed Tylosin Per Ton of Type C Feed 0.08 to 0.10 lbs To be fed so that each animal receives not more than 90 mg per head per day and not less than 60 mg per head per day. Feed continuously as the sole ration. 8 to 10 g Mixing Directions for Liquid Type B Cattle Feeds LIMITATIONS: 1. pH must be between 4.5 and 6.0 2. For liquid feeds stored in recirculating tank systems: Recirculate immediately prior to use for not less than 10 minutes, moving not less than 1 percent of the tank contents per minute from the bottom of the tank to the top. Recirculate daily as described even when not used. 3. For liquid feeds stored in mechanical, air, or other agitation - type tank systems: Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily as described even when not used. 4. Liquid Type B Cattle Feeds must bear an expiration date of 31 days after the date of manufacture.

FDA application 200-484

Directions for Use Read All Directions Carefully Before Mixing and Feeding Tylovet® 40 Type A Medicated Article Net Weight: 50 lbs Do Not Feed Undiluted. (22.68 kgs) CAUTION: Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Active Drug Ingredient: Tylosin (as tylosin phosphate)...40 g per lb Ingredients: Roughage products, pregelatanized starch and dipotassium phosphate. Caution: To ensure adequate mixing, an intermediate blending step should be used prior to manufacturing a complete feed. Do not use in any liquid feed containing sodium metabisulfite or in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Warning: Tylovet 40 may be irritating to unprotected skin and eyes. When mixing and handling Tylovet 40 use protective clothing, impervious gloves and a dust respirator. In case of accidental eye exposure, flush eyes with plenty of water. Exposed skin should be washed with plenty of soap and water. Remove and wash contaminated clothing. Seek medical attention if irritation becomes severe or persists. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report adverse effects, access medical information, or obtain additional product information, call 1-877-994-4883. For reduction in severity of effects of atrophic rhinitis. Feed 100 g of tylosin per ton (2.5 pounds Tylovet 40 per ton) of complete feed. Feed continuously as the sole ration. For control of swine dysentery. Feed 100 g of tylosin per ton (2.5 pounds Tylovet 40 per ton) of complete feed for at least three weeks. Follow with 40 g tylosin per ton (1.0 pound Tylovet 40 per ton) of complete feed until pigs reach market weight. For the treatment and control of swine dysentery. Feed 40 to 100 grams of tylosin (1.0 to 2.5 pounds of Tylovet 40) per ton of complete feed for 2 to 6 weeks immediately after medicating with 250 mg tylosin (as Tylovet Soluble) per gallon in drinking water for 3 to 10 days. For the control of porcine proliferative enteropathies (PPE, ileitis). Feed 100 g tylosin per ton (2.5 pound Tylovet 40 per ton) of complete feed for 21 days. Alternatively, feed 100 g of tylosin per ton (2.5 pound Tylovet 40 per ton) of complete feed for at least three weeks, followed by 40 g tylosin per ton of complete feed until pigs reach market weight. Alternatively, feed 40 to 100 grams of tylosin (1.0 to 2.5 pounds of Tylovet 40) per ton of complete feed for 2 to 6 weeks immediately after medicating with 250 mg tylosin (as Tylovet Soluble) per gallon in drinking water for 3 to 10 days. Feed continuously as the sole ration when feeding Tylovet. NOTICE: Organisms vary in their degree of susceptibility to any chemotherapeutic. If no improvement is observed after recommended treatment, diagnosis and susceptibility should be reconfirmed. Mixing and Feeding Directions for Beef Cattle Feeds For reduction of incidence of liver abscesses in beef cattle associated with Fusobacterium necrophorum and Arcanobacterium pyogenes Tylovet 40 per Ton Of Type C Feed Tylosin Per Ton of Type C Feed 0.2 to 0.25 lbs To be fed so that each animal receives not more than 90 mg per head per day and not less than 60 mg per head per day. Feed continuously as the sole ration. 8 to 10 g Mixing Directions for Liquid Type B Cattle Feeds LIMITATIONS: 1. pH must be between 4.5 and 6.0. 2. For liquid feeds stored in recirculating tank systems: Recirculate immediately prior to use for not less than 10 minutes, moving not less than 1 percent of the tank contents per minute from the bottom of the tank to the top. Recirculate daily as described even when not used. 3. For liquid feeds stored in mechanical, air, or other agitation-type tank systems: Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily as described even when not used. 4. Liquid Type B Cattle Feeds must bear an expiration date of 31 days after the date of manufacture.

FDA application 200-484

For oral use in chickens, turkeys, swine, and honey bees Macrolide Antibiotic Indications: Chickens: For the control of mortality caused by necrotic enteritis (NE) associated with Clostridium perfringens in broiler chickens. As an aid in the treatment of chronic respiratory disease (CRD) associated with Mycoplasma gallisepticum in broiler and replacement chickens. For the control of CRD associated with Mycoplasma gallisepticum at the time of vaccination or other stress in chickens. For the control of CRD associated with Mycoplasma synoviae in broiler chickens. Turkeys: For the reduction in severity of effects of infectious sinusitis associated with Mycoplasma gallisepticum. Swine: For the treatment and control of swine dysentery (SD) associated with Brachyspira hyodysenteriae. For the treatment and control of SD associated with Brachyspira hyodysenteriae when followed immediately by tylosin phosphate Type A medicated article in feed. For the control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis when followed immediately by tylosin phosphate Type A medicated article in feed. Honey Bees: For the control of American Foulbrood (Paenibacillus larvae).

FDA application 200-455

Indications Chickens: For the control of mortality caused by necrotic enteritis (NE) associated with Clostridium perfringens in broiler chickens. As an aid in the treatment of chronic respiratory disease (CRD) associated with Mycoplasma gallisepticum in broiler and replacement chickens. For the control of CRD associated with Mycoplasma gallisepticum at the time of vaccination or other stress in chickens. For the control of CRD associated with Mycoplasma synoviae in broiler chickens. Turkeys: For the reduction in severity of effects of infectious sinusitis associated with Mycoplasma gallisepticum. Swine: For the treatment and control of swine dysentery (SD) associated with Brachyspira hyodysenteriae. For the treatment and control of SD associated with Brachyspira hyodysenteriae when followed immediately by Tylovet Type A medicated article in feed. For the control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis when followed immediately by Tylovet Type A medicated article in feed. Honey Bees: For the control of American Foulbrood (Paenibacillus larvae). Ingredients Tylosin (as tylosin tartrate) ………………………………………… 100 g

FDA application 200-473

En ganado vacuno y vacas lecheras no lactantes, Tylan 200 Inyectable se indica para el tratamiento del complejo respiratorio bovino (fiebre de embarque, neumonía), generalmente asociado con Pasteurella multocida y Arcanobacterium pyogenes, pietín (pododermatitis necrótica), difteria de los terneros provocada por Fusobacterium necrophorum y metritis provocada por Arcanobacterium pyogenes. En cerdos, Tylan 200 Inyectable se indica para el tratamiento de artritis en cerdos provocada por Mycoplasma hyosynoviae, neumonía porcina causada por Pasteurella spp., erisipelas porcinas provocadas por Erysipelothrix rhusiopathiae, disentería porcina asociada con Treponema hyodysenteriae cuando es tratada con el medicamento apropiado a través del alimento y/o el agua para beber. Cada ml contiene 200 mg de actividad de tilosina (como tilosina base) en propilenglicol al 50 por ciento, alcohol bencílico al 4 por ciento y agua para inyección.

FDA application 012-965

En ganado vacuno y vacas lecheras no lactantes, Tylan 50 INYECTABLE se indica para el tratamiento del complejo respiratorio bovino (fiebre de embarque, neumonía), generalmente asociado con Pasteurella multicida y Arcanobacterium pyogenes, pietín (pododermatitis necrótica), difteria de los terneros provocada por Fusobacterium necrophorum y metritis provocada por Arcanobacterium pyogenes. En cerdos, Tylan 50 INYECTABLE se indica para el tratamiento de artritis en cerdos provocada por Mycoplasma hyosynoviae, neumonía porcina causada por Pasteurella spp., erisipelas porcinas provocadas por Erysipelothrix rhusiopathiae, disentería porcina asociada con Treponema hyodysenteriae cuando es tratada con el medicamento apropiado a través del alimento y/o el agua para beber. Cada ml contiene 50 mg de actividad de tilosina (como tilosina base) en propilenglicol al 50 por ciento, alcohol bencílico al 4 por ciento y agua para inyección.

FDA application 012-965

INDICATIONS: In Beef Cattle and Non-lactating Dairy Cattle, BiloVet is indicated for use in the treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated with Pasteurella multocida and Arcanobacterium pyogenes; foot rot (necrotic pododermatitis) and calf diphtheria caused by Fusobacterium necrophorum and metritis caused by Arcanobacterium pyogenes. In Swine, BiloVet is indicated for use in the treatment of swine arthritis caused by Mycoplasma hyosynoviae; swine pneumonia caused by Pasteurella spp.; swine erysipelas caused by Erysipelothrix rhusiopathiae; swine dysentery associated with Treponema hyodysenteriae when followed by appropriate medication in the drinking water and/or feed. Each mL contains 200 mg of tylosin activity (as tylosin base) in 50% propylene glycol with 4% benzyl alcohol, water for injection and hydrochloric acid for pH adjustment.

BiloVet® (tylosin injection)For Use In Cattle and Swine OnlyUse automatic syringe equipment only200 mg per mLAn Antibiotic

In Beef Cattle and Non-lactating Dairy Cattle, Tylan 200 Injection is indicated for use in the treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated with Pasteurella multocida and Arcanobacterium pyogenes; foot rot (necrotic pododermatitis) and calf diphtheria caused by Fusobacterium necrophorum and metritis caused by Arcanobacterium pyogenes. In Swine, Tylan 200 Injection is indicated for use in the treatment of swine arthritis caused by Mycoplasma hyosynoviae; swine pneumonia caused by Pasteurella spp.; swine erysipelas caused by Erysipelothrix rhusiopathiae; swine dysentery associated with Treponema hyodysenteriae when followed by appropriate medication in the drinking water and/or feed. Each mL contains 200 mg of tylosin activity (as tylosin base) in 50 percent propylene glycol with 4 percent benzyl alcohol and water for injection.

FDA application 012-965

In Beef Cattle and Non-lactating Dairy Cattle, Tylan 50 Injection is indicated for use in the treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated with Pasteurella multocida and Arcanobacterium pyogenes; foot rot (necrotic pododermatitis) and calf diphtheria caused by Fusobacterium necrophorum and metritis caused by Arcanobacterium pyogenes. In Swine, Tylan 50 Injection is indicated for use in the treatment of swine arthritis caused by Mycoplasma hyosynoviae; swine pneumonia caused by Pasteurella spp.; swine erysipelas caused by Erysipelothrix rhusiopathiae; swine dysentery associated with Treponema hyodysenteriae when followed by appropriate medication in the drinking water and/or feed. Each mL contains 50 mg of tylosin activity (as tylosin base) in 50 percent propylene glycol with 4 percent benzyl alcohol and water for injection.

FDA application 012-965

Equivalent to 100 g Tylosin per Pound Swine: For the reduction in severity of effects of atrophic rhinitis. For control of swine dysentery associated with Brachyspira hyodysenteriae. For the treatment and control of swine dysentery associated with Brachyspira hyodysenteriae immediately after medicating with Tylovet Soluble (tylosin) drinking water. For control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis. For control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis immediately after medicating with Tylovet Soluble (tylosin) in drinking water. Beef Cattle: For reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterium pyogenes.

FDA application 200-484

For increased rate of weight gain and improved feed efficiency in growing beef heifers fed in confinement for slaughter. Not approved for repeated implantation (reimplantation) with this or any other cattle ear implant in growing beef heifers fed in confinement for slaughter. Safety and effectiveness following re-implantation have not been evaluated. Do not use in beef calves less than 2 months of age, dairy calves, and veal calves because effectiveness and safety have not been established. Do not use in animals intended for subsequent breeding, or in dairy cows. NOTE: Studies have demonstrated that administration of Component TE-IH can result in decreased marbling scores when compared to non-implanted heifers.

FDA application 200-346

For increased rate of weight gain in growing beef steers and heifers on pasture (stocker, feeder, and slaughter). Not approved for repeated implantation (re-implantation) with this or any other cattle ear implant in growing beef steers and heifers on pasture (stocker, feeder, and slaughter). Safety and effectiveness following re-implantation have not been evaluated. Do not use in beef calves less than 2 months of age, dairy calves, and veal calves because effectiveness and safety have not been established. Do not use in animals intended for subsequent breeding, or in dairy cows.

FDA application 200-221

For increased rate of weight gain and improved feed efficiency in growing beef steers fed in confinement for slaughter. Not approved for repeated implantation (re-implantation) with this or any other cattle ear implant in growing beef steers fed in confinement for slaughter. Safety and effectiveness following re-implantation have not been evaluated. Do not use in beef calves less than 2 months of age, dairy calves, and veal calves because effectiveness and safety have not been established. Do not use in animals intended for subsequent breeding, or in dairy cows.

FDA application 200-221

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, the treatment and control of swine dysentery associated with Brachyspira hyodysenteriae, and control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis immediately after medicating with tylosin in drinking water in finishing swine weighing at least 150 lbs and fed a complete ration containing at least 16% crude protein for the last 45 to 90 lbs of gain prior to slaughter. Not for use in swine intended for breeding.

Engain™ and Tylovet®

For increased rate of weight gain and improved feed efficiency in growing beef steers and heifers fed in confinement for slaughter. Not approved for repeated implantation (reimplantation) with this or any other cattle ear implant in growing beef steers and heifers fed in confinement for slaughter. Do not use in beef calves less than 2 months of age, dairy calves, and veal calves because effectiveness and safety have not been evaluated. Do not use in animals intended for subsequent breeding, or in dairy cows.

FDA application 200-346

For increased rate of weight gain in beef calves 45 days of age and older and weighing up to 400 lbs. This implant is not approved for repeated implantation (reimplantation) with this or any other cattle ear implant as safety and effectiveness has not been evaluated. Do not use in calves less than 45 days of age or veal calves because effectiveness and safety have not been evaluated. Do not use in animals intended for subsequent breeding, or in dairy cows.

FDA application 110-315

For increased rate of weight gain and improved feed efficiency, and as an aid in the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati in broiler chickens. <span style="font-size: 10pt; font-family: 'Verdana','sans-serif'; line-height: 115%; mso-fareast-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: EN-US;

For broiler chickens only. Feed continuously as sole ration. Do not feed to laying hens. Not approved for use with pellet binders. May be fatal if accidentally fed to adult turkeys or horses.

Tylovet®100 plus Bio-cox®

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, and control of porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis in finishing swine weighing at least 150 lbs and fed a complete ration containing at least 16% crude protein for the last 45 to 90 lbs of gain prior to slaughter. Not for use in swine intended for breeding.

Engain™ and Tylovet®

For increased rate of weight gain, improved feed efficiency, increased carcass leanness, prevention and control of coccidiosis due to Eimeria bovis and E. zuernii, reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes and suppression of estrus (heat) in heifers fed in confinement for slaughter for the last 20 to 40 days on feed.

Feed continuously as sole ration during the last 20 to 40 days on feed. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Zilpaterol hydrochloride is not for use in animals intended for breeding. Do not allow horses or other equines access to feed containing zilpaterol. Do not use in veal calves. Not to be fed to cattle in excess of 90 mg/head/day in complete feed. If pen consumption of complete feed exceeds 26.5 lb/head/day (90 percent dry matter basis), zilpaterol should not be fed in complete feed. Animals receiving zilpaterol hydrochloride may exhibit increased respiratory rate as well as elevated levels of creatine phosphokinase (CPK) and creatine. Melengestrol acetate is not effective in steers and spayed heifers. Withdrawal periods of three to five days or more should be avoided to prevent the possibility that the heifers may come into estrus (heat) at loading time. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Special considerations: 1) For liquid melengestrol acetate Type C feeds stored in recirculation tank systems, labeling indicates: “Recirculate immediately prior to use for no less than 10 minutes, moving not less than 1 percent of the tank contents from the bottom of the tank to the top. Recirculate daily, as directed in this paragraph even when the Type C feed is not used.” For liquid melengestrol Type C feeds stored in mechanical, air or other agitation-type tank systems: “Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily, as directed in this paragraph, even when the Type C feed is not used.” 2) All labeling for Type C feeds containing zilpaterol hydrochloride provides the warning: The active ingredient in Zilmax® is zilpaterol hydrochloride, a beta2-adrenergic agonist. Not for use in humans. An anti-dust process has been applied to the drug product, Zilmax®, in order to greatly reduce inhalation risk. Extended handling tasks with the potential for dust generation require respiratory protection. Wear appropriate skin protection (e.g., impervious gloves, apron, overalls), if there is a potential for extended skin contact. Wear protective eyewear, if there is a potential for eye contact. If accidental eye contact occurs, immediately rinse with water and consult a physician.

Zilmax®/Rumensin®/Tylovet® 100/MGA®

Read All Directions Carefully Before Mixing and Feeding Tylan™ 40 Type A Medicated Article Do Not Feed Undiluted. Net Weight: 50 lbs (22.68 kg) Caution: Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

FDA application 012-491

For increased rate of weight gain and improved feed efficiency, and as an aid in the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati in broiler chickens.

For broiler chickens only. Feed continuously as sole ration. Do not feed to laying hens. Not approved for use with pellet binders. May be fatal if accidentally fed to adult turkeys or horses.

Tylan® plus Sacox®

Warning: Tylan 40 may be irritating to unprotected skin and eyes. When mixing and handling Tylan 40 use protective clothing, impervious gloves and a dust respirator. In case of accidental eye exposure, flush eyes with plenty of water. Exposed skin should be washed with plenty of soap and water. Remove and wash contaminated clothing. Seek medical attention if irritation becomes severe or persists. The material safety data sheet (MSDS) contains more detailed occupational safety information. To report adverse effects, access medical information, or obtain additional product information, call 1-800-428-4441. For reduction in severity of effects of atrophic rhinitis. Feed 100 g of tylosin per ton (2.5 pounds Tylan 40 per ton) of complete feed. Feed continuously as the sole ration. For control of swine dysentery. Feed 100 g of tylosin per ton (2.5 pounds Tylan 40 per ton) of complete feed for at least three weeks. Follow with 40 g tylosin per ton (1 pound Tylan 40 per ton) of complete feed until pigs reach market weight. For the treatment and control of swine dysentery. Feed 40 to 100 grams of tylosin (1.0 to 2.5 pounds of Tylan 40) per ton of complete feed for 2 to 6 weeks immediately after medicating with 250 mg tylosin (as Tylan Soluble) per gallon in drinking water for 3 to 10 days. For control of porcine proliferative enteropathies (PPE, ileitis). Feed 100 g of tylosin per ton (2.5 pounds Tylan 40 per ton) of complete feed for 21 days. Alternatively, feed 100 g of tylosin per ton (2.5 pounds Tylan 40 per ton) of complete feed for at least three weeks, followed by 40 g tylosin per ton of complete feed until pigs reach market weight. Alternatively, feed 40 to 100 grams of tylosin (1.0 to 2.5 pounds of Tylan 40) per ton of complete feed for 2 to 6 weeks immediately after medicating with 250 mg tylosin (as Tylan Soluble) per gallon in drinking water for 3 to 10 days. Feed continuously as the sole ration when feeding Tylan. NOTICE: Organisms vary in their degree of susceptibility to any chemotherapeutic. If no improvement is observed after recommended treatment, diagnosis and susceptibility should be reconfirmed. Mixing and Feeding Directions for Beef Cattle Feeds For reduction of incidence of liver abscesses in beef cattle associated with Fusobacterium necrophorum and Arcanobacterium pyogenes. Tylan 40 Per Ton Of Type C Feed Tylosin Per Ton Of Type C Feed 0.2 to 0.25 Ibs 8 to 10 g To be fed so that each animal receives not more than 90 mg per head per day and not less than 60 mg per head per day. Feed continuously as the sole ration. Mixing Directions for Liquid Type B Cattle Feeds LIMITATIONS: 1.pH must be between 4.5 and 6.0. 2.For liquid feeds stored in recirculating tank systems: Recirculate immediately prior to use for not less than 10 minutes, moving not less than 1 percent of the tank contents per minute from the bottom of the tank to the top. Recirculate daily as described even when not used. 3.For liquid feeds stored in mechanical, air, or other agitation-type tank system: Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily as described even when not used. 4.Liquid Type B Cattle Feeds must bear an expiration date of 31 days after the date of manufacture. NOT FOR HUMAN USE Store at Room Temperature, 25°C (77ºF). Avoid moisture. Not to be used after the date printed on the bottom of the bag.

FDA application 012-491

This product is intended for use in cattle at high risk of developing ear abscesses. Not recommended for use in cattle at low risk of developing ear abscesses (e.g., dry, clean cattle). The benefit of using a cattle ear implant containing a tylosin tartrate pellet when animals receive a concomitant antimicrobial product has not been evaluated. Withdrawal Periods and Residue Warnings No withdrawal period is required when used according to labeling. Do not use in beef calves less than 2 months of age, dairy calves, and veal calves. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in dairy cows or in animals intended for subsequent breeding. Use in these cattle may cause drug residues in milk and/or calves born to these cows. Implant pellets subcutaneously in ear only. Any other location is a violation of Federal law. Do not attempt salvage of implanted site for human or animal food. USER SAFETY WARNINGS Not for human use. Keep out of reach of children. Restricted Drug (California) - use only as directed.

FDA application 200-346

Ganado bovino: el ganado bovino previsto para consumo humano no se debe faenar durante los 21 días posteriores al último uso de este producto farmacológico. Este producto farmacológico no está aprobado para su uso en ganado bovino lechero hembra de 20 meses de edad o más, incluidas las vacas lecheras secas. El uso en este ganado bovino puede producir residuos farmacológicos en la leche y/o en los terneros nacidos de estas vacas. Este producto no está aprobado para el uso en terneros que se procesarán para carne de ternera. No se ha establecido un período de retiro del fármaco en terneros prerrumiantes. Si se suministra agua para beber con tilosina como tratamiento de seguimiento para la disentería porcina, el animal debe recibir posteriormente alimento que contenga entre 40 y 100 gramos de tilosina por tonelada durante 2 semanas para garantizar la depleción de los residuos de tejidos.

FDA application 012-965

RESIDUE WARNING: Cattle: Cattle intended for human consumption must not be slaughtered within 21 days of the last use of this drug product. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. This product is not approved for use in calves intended to be processed for veal. A withdrawal period has not been established in pre-ruminating calves. If tylosin medicated drinking water is used as a follow-up treatment for swine dysentery, the animal should thereafter receive feed containing 40 to 100 grams of tylosin per ton for 2 weeks to assure depletion of tissue residues.

BiloVet® (tylosin injection)For Use In Cattle and Swine OnlyUse automatic syringe equipment only200 mg per mLAn Antibiotic

Warning: Tylan 100 may be irritating to unprotected skin and eyes. When mixing and handling Tylan 100 use protective clothing, impervious gloves and a dust respirator. In case of accidental eye exposure, flush eyes with plenty of water. Exposed skin should be washed with plenty of soap and water. Remove and wash contaminated clothing. Seek medical attention if irritation becomes severe or persists. The material safety data sheet (MSDS) contains more detailed occupational safety information. To report adverse effects, access medical information, or obtain additional product information, call 1-800-428-4441.

FDA application 012-491

Residue Warnings: Chickens must not be slaughtered for food within 24 hours after treatment. Do not use in layers producing eggs for human consumption. Turkeys must not be slaughtered for food within five days after treatment. Do not use in layers producing eggs for human consumption. Swine must not be slaughtered for food within 48 hours after treatment. Honey Bees: The drug should be fed early in the spring or fall and consumed by the bees before the main honey flow begins, to avoid contamination of production honey. Complete treatments at least 4 weeks prior to main honey flow.

FDA application 200-455

No withdrawal period is required when used according to labeling. Do not use in beef calves less than 2 months of age, dairy calves, and veal calves. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in dairy cows or in animals intended for subsequent breeding. Use in these cattle may cause drug residues in milk and/or calves born to these cows. Implant pellets subcutaneously in ear only. Any other location is a violation of Federal law. Do not attempt salvage of implanted site for human or animal food.

FDA application 200-346

ESTE PRODUCTO NO DEBE UTILIZARSE EN SERES HUMANOS. MANTENER FUERA DEL ALCANCE DE LOS NIÑOS. Pueden ocurrir reacciones adversas, incluidos shock y muerte, en caso de sobredosis en crías de cerdos. No administrar la inyección a cerdos que pesen menos de 25 libras (0.5 ml) con la jeringa común. Se recomienda usar la inyección Tylan 50 en cerdos que pesen menos de 25 libras. No administrar a caballos u otros equinos. La inyección de tilosina en equinos ha resultado mortal.

FDA application 012-965

ESTE PRODUCTO NO DEBE UTILIZARSE EN SERES HUMANOS. MANTENER FUERA DEL ALCANCE DE LOS NIÑOS. Pueden ocurrir reacciones adversas, incluidos shock y muerte, en caso de sobredosis en crías de cerdos. No administrar la inyección a cerdos que pesen menos de 6.25 libras (0.5 ml) a menos que la jeringa pueda administrar 0.1 ml de forma precisa. No administrar a caballos u otros equinos. La inyección de tilosina en equinos ha resultado mortal.

FDA application 012-965

WARNINGS: NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN. Adverse reactions, including shock and death may result from overdosage in baby pigs. Do not attempt injection into pigs weighing less than 25 pounds (0.5 mL) with the common syringe. It is recommended that tylosin 50 mg/mL injection be used in pigs weighing less than 25 lbs. Do not administer to horses or other equines. Injection of tylosin in equines has been fatal.

BiloVet® (tylosin injection)For Use In Cattle and Swine OnlyUse automatic syringe equipment only200 mg per mLAn Antibiotic

NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN. Adverse reactions, including shock and death, may result from overdosage in baby pigs. Do not attempt injection into pigs weighing less than 6.25 pounds (0.5 mL) unless the syringe is capable of accurately delivering 0.1 mL. Do not administer to horses or other equines. Injection of tylosin in equines has been fatal.

FDA application 012-965

This product is intended for use in cattle at high risk of developing ear abscesses. Not recommended for use in cattle at low risk of developing ear abscesses (e.g., dry, clean cattle). The benefit of using a cattle ear implant containing a tylosin tartrate pellet when animals receive a concomitant antimicrobial product has not been evaluated.

FDA application 200-346

Ganado porcino: el ganado porcino previsto para consumo humano no se debe faenar durante los 14 días posteriores al último uso de este producto farmacológico.

FDA application 012-965

Warnings User Safety Warnings: Not for Human Use. Keep out of Reach of Children. Avoid contact with human skin. Exposure to tylosin may cause a rash.

FDA application 200-455

RESIDUE WARNING: Swine: Swine intended for human consumption must not be slaughtered within 14 days of the last use of this drug product.

FDA application 012-965

Not for use in humans. Keep out of reach of children. Restricted Drug (California) - use only as directed.

FDA application 200-346

To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae. Approved by FDA under ANADA # 200-455 Distributed by: MWI Boise, ID 83705 www.VetOne.net

FDA application 200-455

To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Huvepharma, Inc., at 1-877-994-4883 or www.huvepharma.us. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae. Net Weight: 50 lbs (22.68 kg)

FDA application 200-484

Growing beef steers and heifers on pasture (stocker, feeder, and slaughter)

Administer one implant containing 40 mg trenbolone acetate, 8 mg estradiol, and 29 mg tylosin tartrate (3 pellets) to each steer or heifer by subcutaneous implantation in the middle-third of the ear.

Subcutaneous

Component™ TE-G with Tylan™

Cattle (steers fed in confinement for slaughter excluding veal)

80 mg trenbolone acetate and 16 mg estradiol (one implant consisting of 5 pellets, each of 4 pellets containing 20 mg trenbolone acetate and 4 mg estradiol, and 1 pellet containing 29 mg tylosin tartrate) per implant dose.

Subcutaneous

Implant subcutaneously in ear only. Do not use in animals intended for subsequent breeding or in dairy animals. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component™ TE-IS

Cattle (steers fed in confinement for slaughter excluding veal)

120 milligrams (mg) trenbolone acetate and 24 mg estradiol (one implant consisting of 6 pellets, each pellet containing 20 mg trenbolone acetate and 4 mg estradiol) per implant dose.

Subcutaneous

Implant subcutaneously in ear only. Do not use in animals intended for subsequent breeding or in dairy animals. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component™ TE-IS

Cattle (slaughter, stocker, feeder steers, and heifers)

40 mg trenbolone acetate and 8 mg estradiol (one implant consisting of 2 pellets, each pellet containing 20 mg trenbolone acetate and 4 mg estradiol) per implant dose.

Subcutaneous

Implant subcutaneously in ear only. Do not use in animals intended for subsequent breeding or in dairy animals. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component™ TE-IS

Growing beef steers fed in confinement for slaughter

Administer one implant containing 120 mg trenbolone acetate, 24 mg estradiol, and 29 mg tylosin tartrate (7 pellets) to each steer by subcutaneous implantation in the middle-third of the ear.

Subcutaneous

Component™ TE-S with Tylan™

Cattle (heifers fed in confinement for slaughter)

Melengestrol acetate, 0.25 to 0.50 milligram per head per day, plus monensin (as monensin sodium) at 50 to 360 milligrams per head per day, plus tylosin (as tylosin phosphate), 90 milligrams per head per day. To attain these amounts: Add 0.5 to 2.0 pounds per head per day of a liquid or dry medicated feed containing 0.125 to 1.0 milligram of melengestrol acetate per pound to a medicated feed containing 5 to 30 grams of monensin and 8 to 10 grams of tylosin per ton; or; Add 0.5 to 2.0 pounds per head per day of a liquid or dry medicated feed containing 0.125 to 1.0 milligram of melengestrol acetate plus 25 to 720 milligrams of monensin per pound to 4.5 to 18 pounds of a dry medicated feed containing 10 to 40 grams of tylosin per ton; or; Add 0.5 to 2.0 pounds per head per day of a dry medicated feed containing 0.125 to 1.0 milligram of melengestrol acetate (from a dry Type A article), 25 to 600 milligrams of monensin, plus 45 to 180 milligrams of tylosin per pound to a ration of non-medicated feed.

Oral

For heifers fed in confinement for slaughter.

MGA® 100 / Rumensin® / Tylan®

Cattle (heifers fed in confinement for slaughter)

Feed continuously as sole rotation containing 9.8 to 24.6 grams/ton ractopamine to provide 90 to 430 mg/hd/day ractopamine; combined with monensin 10 to 40 grams per ton to provide 0.14 to 0.42 mg monensin/lb of body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/head/day; tylosin 8 to 10 grams per ton to provide 60 to 90 mg/head/day tylosin for the last 28 to 42 days on feed. Mix or top dress with medicated feed containing 0.125 to 1.0 mg melengestrol acetate per pound fed at the rate of 0.5 to 2.0 lb/head/day to provide 0.25 to 0.5 milligrams per head per day for the last 28 to 42 days on feed.

Oral

Melengestrol acetate is not effective in steers and spayed heifers. Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at time of loading. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Ractopamine HCl is not for animals intended for breeding. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Special considerations: Mixing directions for liquid melengestrol acetate Type C feeds storedin recirculation tank systems, labeling indicates: “Recirculate immediately prior to use for no less than 10 minutes, moving not less than 1 percent of the tank contents from the bottom of the tankto the top. Recirculate daily, as directed in this paragraph evenwhen the Type C feed is not used." For liquid melengestrol Type C feeds stored in mechanical, air or other agitation-type tank systems:“Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily, as directed in this paragraph, even when the Type C feed is not used.”

Heifermax™ / Optaflexx® / Rumensin® / Tylan®

Cattle (heifers fed in confinement for slaughter)

Complete feed: Feed continuously as sole ration containing 9.8 to 24.6 g/ton ractopamine to provide 90 to 430 mg/hd/day ractopamine; 10 to 40 g/ton monensin to provide 0.14 to 0.42 mg monensin/lb of body weight per day, depending on severity of coccidiosis challenge, up to 480 mg/head/day; 8 to 10 g/ton tylosin to provide 60 to 90 mg/head/day tylosin for the last 28 to 42 days on feed. Mix or top dress with medicated feed containing 0.125 to 1.0 mg melengestrol acetate per pound fed at the rate of 0.5 to 2.0 lb/head/day to provide 0.25 to 0.5 mg melengestrol acetate per head per day for the last 28 to 42 days on feed.

Oral

Melengestrol acetate is not effective in steers and spayed heifers. Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at time of loading. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Ractopamine HCl is not for animals intended for breeding.Special considerations:Mixing directions for liquid melengestrol acetate Type C feeds stored in recirculation tank systems, labeling indicates: “Recirculate immediately prior to use for no less than 10 minutes, moving not less than 1 percent of the tank contents from the bottom of the tank to the top. Recirculate daily, as directed in this paragraph even when the Type C feed is not used.” For liquid melengestrol Type C feeds stored in mechanical, air or other agitation-type tank systems: “Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily, as directed in this paragraph, even when the Type C feed is not used.”

Optaflexx™ and Rumensin™ and Tylan™and MGA®

Cattle (heifers fed in confinement for slaughter)

Component Feed: 6.8 to 24 g/ton zilpaterol to provide 60 mg/head/day zilpaterol; 10 to 40 g/ton monensin, to provide 0.14 to 0.42 mg/lb body weight/day monensin, depending on the severity of the coccidiosis challenge, up to 480 mg/head/day monensin; and 8 to 10 g/ton tylosin to provide 60 to 90 mg/head/day tylosin; mixed or top dressed with medicated feed containing 0.125 to 1.0 mg melengestrol acetate per pound fed at the rate of 0.5 to 2.0 lb/head/day to provide 0.25 to 0.5 mg melengestrol acetate/head/day.

Oral

Feed continuously to cattle during the last 20 to 40 dayson feed. Do not allow horses or other equines access to feed containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Zilpaterol hydrochloride is not for use in animals intended for breeding. Do not allow horses or other equines access to feed containing zilpaterol. Do not use in veal calves. Animals receiving zilpaterol hydrochloride may exhibit increased respiratory rate as well as elevated levels of creatine phosphokinase (CPK) and creatine. Melengestrol acetate is not effective in steers and spayed heifers. Withdrawal periods of three to five days or more should be avoided to prevent the possibility that the heifers may come into estrus (heat) at loading time. Special considerations:1) For liquid melengestrol acetate Type C feeds stored in recirculation tank systems, labeling indicates: “Recirculate immediately prior to use for no less than 10 minutes, moving not less than 1 percent of the tank contents from the bottom of the tank to the top. Recirculate daily, as directed in this paragraph even when the Type C feed is not used.” For liquid melengestrol Type C feeds stored in mechanical, air or other agitation-type tank systems: “Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily, as directed in this paragraph, even when the Type C feed is not used.”2) All labeling for Type C feeds containing zilpaterol hydrochloride provides the warning: The active ingredient in Zilmax® is zilpaterol hydrochloride, a beta2-adrenergic agonist. Not for use in humans. An anti-dust process has been applied to the drug product, Zilmax®, in order to greatly reduce inhalation risk. Extended handling tasks with the potential for dust generation require respiratory protection. Wear appropriate skin protection (e.g., impervious gloves, apron, overalls), if there is a potential for extended skin contact. Wear protective eyewear, if there is a potential for eye contact. If accidental eye contact occurs, immediately rinse with water and consult a physician.

Zilmax® and Rumensin™ and Tylan™ and MGA®

Cattle (heifers fed in confinement for slaughter)

200 mg of trenbolone acetate (one implant consisting of 11 pellets, each of 10 pellets containing 20 mg of trenbolone acetate, and 1 pellet containing 29 mg of tylosin tartrate) per implant dose. Use last 63 days before slaughter.

Subcutaneous

Implant subcutaneously in ear only. Do not use in animals intended for subsequent breeding or in dairy animals. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component® T-H with Tylan®

Cattle (heifers fed in confinement for slaughter)

Melengestrol acetate (0.25 to 2 g/ton) in combination with monensin (10 to 40 g/ton) and tylosin (8 to 10 g/ton).

Oral

Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Feed continuously as sole ration to heifers at a rate of 0.5 to 2.0 pounds per head per day to provide 0.25 to 0.5 mg/head/day melengestrol acetate and 0.14 to 0.42 mg monensin/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/head/day and 60 to 90 mg/head/day tylosin. The melengestrol acetate portion of this Type C medicated feed must be mixed into the complete feed containing 10 to 40 g/ton monensin and 8 to 10 g/ton tylosin at feeding into the amount of complete feed consumed by an animal per day. Melengestrol acetate is for use only in heifers being fed in confinement for slaughter. Not effective in steers or spayed heifers. Heifers fed in confinement for slaughter: Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at the time of loading. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle and goat feed is safe for use in cattle and goats only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

HeifermaX™ 500 / Rumensin™ / Tylan™

Cattle (heifers)

Melengestrol acetate, 0.25 to 0.50 milligram per head per day, plus tylosin (as tylosin phosphate) at 60 to 90 milligrams per head per day. To attain this amount: Add 0.5 to 2.0 pounds per head per day of a liquid or dry medicated feed containing 0.125 to 1.0 milligram of melengestrol acetate per pound to a medicated feed containing 8 to 10 grams of tylosin per ton; Add 0.5 to 2.0 pounds per head per day of a liquid or dry medicated feed containing 0.125 to 1.0 milligram of melengestrol acetate per pound to 4.5 to 18 pounds of a dry medicated feed containing 10 to 40 grams of tylosin per ton; or Add 0.5 to 2.0 lb/head/day of a liquid or dry medicated feed containing 0.125 to 1.0 mg melengestrol acetate plus 45 to 180 mg tylosin/ lb to a ration of nonmedicated feed.

Oral

Feed continuously as sole ration. MGA is for use only in heifers being fed in confinement for slaughter. Not effective in steers and spayed heifers. When mixing and handling tylosin, use protective clothing, impervious gloves and a dust mask. Operators should wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Heifermax™ 500 Liquid Premix and Tylan®

Cattle (heifers)

Melengestrol acetate, 0.25 to 0.50 milligram per head per day, plus lasalocid (as lasalocid sodium), 100 to 360 milligrams per head per day, and tylosin (as tylosin phosphate), 90 milligrams per head per day. To attain this amount:Add 0.5 to 2.0 pounds per head per day of a liquid or dry medicated feed containing 0.125 to 1.0 milligram of melengestrol acetate per pound to a medicated feed containing 10 to 30 grams of lasalocid and 8 to 10 grams of tylosin per ton; or Add 0.5 to 2.0 pounds per head per day of a liquid or dry medicated feed containing 0.125 to 1.0 milligram of melengestrol acetate per pound plus 50 to 720 milligrams of lasalocid per pound to 8 to 10 grams of tylosin per ton.

Oral

For heifers being fed in confinement for slaughter. Not effective in steers and spayed heifers. This combination may only be marketed as a pelleted product. Do not allow horses or other equines access to premixes or supplements containing lasalocid, as ingestion may be fatal. The safety of lasalocid in unapproved species has not been established. Mixing errors resulting in excessive concentrations of lasalocid could be fatal to cattle and sheep. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

HeifermaX® 500 plus Bovatec® and Tylan™

Cattle (heifers)

Feed 0.25 to 2.0 g/ton melengestrol acetate to heifers at the rate of 0.5 to 2.0 lb/hd/day as a top dress or mixed into a complete feed to provide 0.25 to 0.5 mg melengestrol acetate per head per day and 100 to 1440 g/ton lasalocid to provide 100 to 360 mg lasalocid per head per day. Melengestrol acetate and lasalocid may be fed continuously throughout the time the heifers are being grown and finished for slaughter. May be fed to heifers in combination with a complete feed containing 8 to 10 g of tylosin per ton for reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterium pyogenes.

Oral

When tylosin is fed in combination with melengestrol acetate and lasalocid, the level of tylosin is limited to 90 mg/hd/day. Melengestrol acetate is only for use in heifers being fed in confinement for slaughter. Not effective in steers and spayed heifers. This combination may only be marketed as a pelleted product. Do not allow horses or other equines access to premixes or supplements containing lasalocid, as ingestion may be fatal. The safety of lasalocid in unapproved species has not been established. Mixing errors resulting in excessive lasalocid concentrations could be fatal to cattle and sheep. When mixing and handling lasalocid, use protective clothing, impervious gloves and a dust mask, avoid contact with eyes. Operators should wash hands thoroughly with soap and water after handling. Use melengestrol acetate only as directed.

MGA® and Bovatec® and Tylan™

Cattle (heifers)

Feed 0.25 to 2.0 g/ton melengestrol acetate to heifers at the rate of 0.5 to 2.0 lb/hd/day as a top dress or mixed into a complete feed to provide 0.25 to 0.5 mg melengestrol acetate per head lasalocid per day and 100 to 1440 g/ton lasalocid to provide 100 to 360 mg lasalocid per head per day and 90 to 360 g/ton tylosin to provide 90 mg tylosin per head per day. Melengestrol acetate, lasalocid, and tylosin may be fed continuously throughout the time the heifers are being grown and finished for slaughter.

Oral

When tylosin is fed in combination with melengestrol acetate and lasalocid, the level of tylosin is limited to 90 mg/hd/day. For use only in heifers being fed in confinement for slaughter. Not effective in steers and spayed heifers. This combination may only be marketed as a pelleted product. Do not allow horses or other equines access to premixes or supplements containing lasalocid, as ingestion may be fatal. The safety of lasalocid in unapproved species has not been established. Mixing errors resulting in excessive concentrations of lasalocid could be fatal to cattle and sheep. When mixing and handling lasalocid, use protective clothing, impervious gloves and a dust mask, avoid contact with eyes. Operators should wash hands thoroughly with soap and water after handling. Use melengestrol acetate only as directed.

MGA® and Bovatec® and Tylan™

Cattle (fed in confinement for slaughter)

Component Feed: 6.8 to 24 g/ton zilpaterol to provide 60 mg/head/day zilpaterol; 10 to 40 g/ton monensin, to provide 0.14 to 0.42 mg/lb body weight/day monensin, depending on the severity of the coccidiosis challenge, up to 480 mg/head/day monensin; and 8 to 10 g/ton tylosin to provide 60 to 90 mg/head/day tylosin.

Oral

Feed continuously during the last 20 to 40 days on feed. Do not allow horses or other equines access to feed containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.Zilpaterol hydrochloride is not for use in animals intended for breeding. Do not allow horses or other equines access to feed containing zilpaterol. Do not use in veal calves. Animals receiving zilpaterol hydrochloride may exhibit increased respiratory rate aswell as elevated levels of creatine phosphokinase (CPK) and creatine.Special considerations:1) Labeling for Type B feeds used to manufacture Type C complete feeds must bear the caution statement: Not to be fed to cattle in excess of 90 mg/head/day in complete feed. If pen consumption of complete feed exceeds 26.5 lb/head/day (90 percent dry matter basis), zilpaterol should not be fed in complete feed. 2) Type B Liquid Feeds can be manufactured containing 68 to 680 g zilpaterol hydrochloride/ton. Inadequate mixing (recirculation or agitation) of monensin liquid Type B or Type C medicated feeds has resulted in increased monensin concentration, which has been fatal to cattle. For liquid feeds stored in recirculating tank systems: Recirculate immediately prior to use for not less than 10 minutes, moving not less than 1 percent of the tank contents per minute from the bottom of the tank to the top. Recirculate daily as described even when not used. For liquid feeds stored in mechanical, air or other agitation-type tank systems: Agitate immediately prior to use for not less than 10 minutes, creating turbulence at the bottom of the tank that is visible at the top. Agitate daily as described even when not used.3) All labeling for Type B and Type C feeds provides the warning: The active ingredient in Zilmax® is zilpaterol hydrochloride, a beta2-adrenergic agonist. Not for use in humans. An anti-dust process has been applied to the drug product, Zilmax®, in order to greatly reduce inhalation risk. Extended handling tasks with the potential for dust generation require respiratory protection. Wear appropriate skin protection (e.g., impervious gloves, apron, overalls), if there is a potential for extended skin contact. Wear protective eyewear, if there is a potential for eye contact. If accidental eye contact occurs, immediately rinse with water and consult a physician.

Zilmax® and Rumensin™ and Tylan™

Cattle (fed in confinement for slaughter)

Complete feed: 6.8 g/ton zilpaterol to provide 60 to 90 mg/head/day zilpaterol; 10 to 40 g/ton monensin, to provide 0.14 to 0.42 mg/lb body weight/day monensin, depending on the severity of the coccidiosis challenge, up to 480 mg/head/day monensin; and 8 to 10 g/ton tylosin to provide 60 to 90 mg/head/day tylosin.

Oral

Feed continuously as sole ration during the last 20 to 40 days on feed. Do not allow horses or other equines access to feedscontaining monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.Zilpaterol hydrochloride is not for use in animals intended for breeding. Do not allow horses or other equines access to feed containing zilpaterol. Do not use in veal calves. Not to be fed to cattle in excess of 90 mg/head/day in complete feed. If pen consumption of complete feed exceeds 26.5 lb/head/day (90 percent dry matter basis), zilpaterol should not be fed in complete feed. Animals receiving zilpaterol hydrochloride may exhibit increased respiratory rate as well as elevated levels of creatine phosphokinase (CPK) and creatine.

Zilmax® and Rumensin™ and Tylan™

Cattle fed in confinement for slaughter

Monensin is added to feedlot cattle diets at concentrations of 10 to 40 g of monensin USP per ton of complete feed at a rate of 0.14 to 0.42 mg monensin/lb of body weight, depending on severity of coccidiosis challenge, up to 480 mg monensin/head/day.Monensin is added to feedlot cattle diets at concentrations of 5 to 40 g of monensin USP per ton of complete feed for improved feed efficiency to provide 50 to 480 mg monensin/head/day.Tylosin is added to the cattle diets at concentrations of 8 to 10 g of tylosin phosphate per ton of complete feed to provide 60 to 90 mg tylosin/head/day.

Oral

Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Rumensin® plus Tylovet® 100

Cattle fed in confinement for slaughter

Not to exceed 800 g/ton Optaflexx™. Feed a minimum of 1.0 lb/hd/day Ractopamine Type C Top Dress TD + MT continuously to cattle fed in confinement for slaughter, to provide 70 to 400 mg/head/day ractopamine for the last 28 to 42 days on feed. Feed on top of a ration containing 10 to 40 g/ton monensin and 8 to 10 g/ton tylosin phosphate, to provide 0.14 to 0.42 mg monensin/lb body weight/day, depending on the severity of the coccidiosis challenge, up to 480 mg/hd/day and 60 to 90 mg/hd/day tylosin.

Oral

Optaflexx™and Monovet® and Tylovet®

Cattle fed in confinement for slaughter

8.2 to 24.6 g/ton of Optaflexx™, 10 to 40 g/ton of Monovet®, and 8 to 10 g/ton of Tylovet®. Feed continuously as sole ration to provide 70 to 430 mg/hd/day ractopamine and 0.14 to 0.42 mg monensin/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/hd/day and 60 to 90 mg/hd/day tylosin for the last 28 to 42 days on feed.

Oral

Optaflexx™and Monovet® and Tylovet®

Cattle fed in confinement for slaughter

9.8 to 24.6 g/ton Optaflexx™, 10 to 40 g/ton Monovet®, and 8 to 10 g/ton Tylovet®. Feed continuously as sole ration to provide 90 to 430 mg/hd/day ractopamine and 0.14 to 0.42 mg monensin/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/hd/day and 60 to 90 mg/hd/day tylosin for the last 28 to 42 days on feed.

Oral

Optaflexx™and Monovet® and Tylovet®

Cattle fed in confinement for slaughter

5 to 40 g/ton of Monovet® and 8 to 10 g/ton of Tylovet®. Feed continuously as sole ration to provide 50 to 480 mg/hd/day monensin and 60 to 90 mg/hd/day tylosin. No additional improvement in feed efficiency has been shown from feeding monensin at levels greater than 30 g/ton (360 mg monensin per head per day).

Oral

Monovet® and Tylovet®

Cattle fed in confinement for slaughter

10 to 40 g/ton of Monovet® and 8 to 10 g/ton of Tylovet®. Feed continuously as sole ration to provide 0.14 to 0.42 mg monensin/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/hd/day and 60 to 90 mg/hd/day tylosin.

Oral

Monovet® and Tylovet®

Cattle fed in confinement for slaughter

10 to 40 g/ton to provide 0.14 to 0.42 mg/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/head/day, of monensin (as Monovet®). Feed continuously as sole ration for the last 28 to 42 days on feed.

Oral

Optigrid® and Monovet® and Tylovet®

Cattle fed in confinement for slaughter

Not to exceed 800 g/ton feeding a minimum of 1.0 lb/head/day to provide 70 to 400 mg/head/day of ractopamine hydrochloride (as Optigrid®). Feed continuously for the last 28 to 42 days on feed.

Oral

Optigrid® and Monovet® and Tylovet®

Cattle fed in confinement for slaughter

8.2 to 24.6 g/ton to provide 70 to 430 mg/head/day of ractopamine hydrochloride (as Optigrid®). Feed continuously as sole ration for the last 28 to 42 days on feed.

Oral

Optigrid® and Monovet® and Tylovet®

Cattle fed in confinement for slaughter

Ractopamine hydrochloride top dress (not to exceed 800 g/ton) to be fed with a ration containing 10 to 40 g/ton monensin and 8 to 10 g/ton tylosin phosphate.

Oral

Feed a minimum of 1.0 lb/hd/day continuously to cattle fed in confinement for slaughter, to provide 70 to 400 mg/head/day ractopamine for the last 28 to 42 days on feed. Feed on top of a ration containing 10 to 40 g/ton monensin and 8 to 10 g/ton tylosin phosphate, to provide 0.14 to 0.42 mg monensin/lb body weight/day (depending on the severity of the coccidiosis challenge, up to 480 mg/hd/day), and 60 to 90 mg/hd/day tylosin.

Optaflexx™ and Rumensin™ and Tylan™

Cattle fed in confinement for slaughter

8 to 10 g/ton to provide 60 to 90 mg/head/day of tylosin phosphate (as Tylovet®). Feed continuously as sole ration for the last 28 to 42 days on feed.

Oral

Optigrid® and Monovet® and Tylovet®

Cattle fed in confinement for slaughter

Ractopamine hydrochloride (8.2 to 24.6 g/ton) in combination with monensin (10 to 40 g/ton), and tylosin phosphate (8 to 10 g/ton).

Oral

Feed continuously as sole ration to provide 70 to 430 mg ractopamine per hd/day and 0.14 to 0.42 mg monensin per lb body weight/day (depending on severity of coccidiosis challenge, up to 480 mg/hd/day), and 60 to 90 mg tylosin per hd/day for the last 28 to 42 days on feed.

Optaflexx™ and Rumensin™ and Tylan™

Cattle fed in confinement for slaughter

Monensin, 5 to 40 grams per ton of feed, plus tylosin 8 to 10 grams per ton of feed.

Oral

Feed only to cattle being fed in confinement for slaughter. Feed continuously as sole ration to provide 50 to 480 monensin mg/hd/day and 60 to 90 tylosin mg/hd/day. No additional improvement in feed efficiency has been shown from feeding monensin at levels greater than 30 g/ton (360 mg monensin per head per day).

Rumensin™ and Tylan™

Growing beef steers and heifers fed in confinement for slaughter

Feed as the sole ration to provide 22.7 mg of decoquinate per 100 lb. of body weight per day, 50 to 360 mg of monensin per head per day, and 60 to 90 mg tylosin (as tylosin phosphate) per head per day. Feed for at least 28 days during periods of coccidiosis exposure or when experience indicates that coccidiosis is likely to be a hazard.

Oral

Deccox® and Rumensin™ and Tylovet®

Growing beef steers and heifers fed in confinement for slaughter

Administer one implant containing 200 mg trenbolone acetate, 20 mg estradiol, and 29 mg tylosin tartrate (11 pellets) to each steer or heifer by subcutaneous implantation in the middle-third of the ear.

Subcutaneous

Component™ TE-200 with Tylan™

Cattle (steers fed in confinement for slaughter)

140 mg trenbolone acetate (one implant consisting of 8 pellets, each of 7 pellets containing 20 milligrams trenbolone acetate, and 1 pellet containing 29 mg tylosin tartrate) per implant dose. Use 126 days prior to slaughter; should be reimplanted once after 63 days.

Subcutaneous

Implant subcutaneously in ear only. Do not use in animals intended for subsequent breeding or in dairy animals. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component® T-S with Tylan®

Cattle (beef)

8 to 10 grams per ton of feed.

Oral

As tylosin phosphate. Each animal must receive not more than 90 mg/head/day and not less than 60 mg/head/day. Feed continuously as sole ration.

TYLAN™ 40

Beef Cattle

8 to 10 g/ton of tylosin (0.08 to 0.10 lbs of Tylovet 100) to be fed so that each animal receives not more than 90 mg per head per day and not less than 60 mg per head per day. Feed continuously as the sole ration.

Oral

Tylovet® 100

Beef Cattle

8-10 grams per ton of feed. (Not more than 90 mg/head/day and not less than 60 mg/head/day).

Oral

To ensure adequate mixing, an intermediate blending step should be used prior to manufacturing a complete feed. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

Tylan™ 100

Beef Cattle

8 to 10 grams per ton of feed.

Oral

Each animal must not receive not more than 90 milligrams per day and not less than 60 milligrams per day. Feed continuously as sole ration.

TYLAN™ 20

Feed 0.25 to 2.0 g/ton melengestrol acetate to heifers at the rate of 0.5 to 2.0 lb/hd/day as a top dress or mixed into a complete feed to provide 0.25 to 0.5 mg melengestrol acetate per head per day and 100 to 1440 g/ton lasalocid to provide 100 to 360 mg lasalocid per head per day. Melengestrol acetate and lasalocid may be fed continuously throughout the time the heifers are being grown and finished for slaughter. May be fed to heifers in combination with a complete feed containing 8 to 10 g of tylosin per ton for reduction of incidence of liver abscesses associated with Fusobacterium necrophorum and Arcanobacterium pyogenes.

Oral

When tylosin is fed in combination with melengestrol acetate and lasalocid, the level of tylosin is limited to 90 mg/hd/day. Melengestrol acetate is only for use in heifers being fed in confinement for slaughter. Not effective in steers and spayed heifers. This combination may only be marketed as a pelleted product. Do not allow horses or other equines access to premixes or supplements containing lasalocid, as ingestion may be fatal. The safety of lasalocid in unapproved species has not been established. Mixing errors resulting in excessive lasalocid concentrations could be fatal to cattle and sheep. When mixing and handling lasalocid, use protective clothing, impervious gloves and a dust mask, avoid contact with eyes. Operators should wash hands thoroughly with soap and water after handling. Use melengestrol acetate only as directed.

MGA®/ Bovatec®/ Tylovet® 100

Feed 0.25 to 2.0 g/ton melengestrol acetate to heifers at the rate of 0.5 to 2.0 lb/hd/day as a top dress or mixed into a complete feed to provide 0.25 to 0.5 mg melengestrol acetate per head lasalocid per day and 100 to 1440 g/ton lasalocid to provide 100 to 360 mg lasalocid per head per day and 90 to 360 g/ton tylosin to provide 90 mg tylosin per head per day. Melengestrol acetate, lasalocid, and tylosin may be fed continuously throughout the time the heifers are being grown and finished for slaughter.

Oral

When tylosin is fed in combination with melengestrol acetate and lasalocid, the level of tylosin is limited to 90 mg/hd/day. For use only in heifers being fed in confinement for slaughter. Not effective in steers and spayed heifers. This combination may only be marketed as a pelleted product. Do not allow horses or other equines access to premixes or supplements containing lasalocid, as ingestion may be fatal. The safety of lasalocid in unapproved species has not been established. Mixing errors resulting in excessive concentrations of lasalocid could be fatal to cattle and sheep. When mixing and handling lasalocid, use protective clothing, impervious gloves and a dust mask, avoid contact with eyes. Operators should wash hands thoroughly with soap and water after handling. Use melengestrol acetate only as directed.

MGA®/ Bovatec®/ Tylovet® 100

Ractopamine hydrochloride top dress (not to exceed 800 g/ton) to be fed with a ration containing 10 to 40 g/ton monensin and 8 to 10 g/ton tylosin phosphate.

Oral

Feed a minimum of 1.0 lb/hd/day Ractopamine Type C Top Dress TD + MT continuously to cattle fed in confinement for slaughter, to provide 70 to 400 mg/head/day ractopamine for the last 28 to 42 days on feed. Feed on top of a ration containing 10 to 40 g/ton monensin and 8 to 10 g/ton tylosin phosphate, to provide 0.14 to 0.42 mg monensin/lb body weight/day, depending on the severity of the coccidiosis challenge, up to 480 mg/hd/day and 60 to 90 mg/hd/day tylosin. Do not allow horses or other equines access to feed containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Ractopamine HCl is not for animals intended for breeding.

Actogain® and Rumensin™ and Tylan™

Ractopamine hydrochloride (9.8 to 24.6 g/ton) in combination with monensin sodium (10 to 40 g/ton) and tylosin phosphate (8 to 10 g/ton).

Oral

Feed continuously as sole ration to provide 90 to 430 mg/hd/day ractopamine and 0.14 to 0.42 mg monensin/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/hd/day and 60 to 90 mg/hd/day tylosin for the last 28 to 42 days on feed.

Actogain® and Rumensin™ and Tylan™

Cattle (Beef)

8- 10 grams per ton of feed.

Oral

As tylosin phosphate. Each animal must receive not more than 90 milligrams per day and not less than 60 milligrams per day. Feed continuously as sole ration.

Hy-Con Tylan® Premix

Heifers fed in confinement for slaughter

0.25 to 2 g/ton (0.0000276 to 0.00022%) of MGA®, 10 to 40 g/ton of Monovet®, and 8 to 10 g/ton of Tylovet®. Feed continuously as sole ration to heifers at a rate of 0.5 to 2.0 pounds per head per day to provide 0.25 to 0.5 mg/head/day melengestrol acetate and 0.14 to 0.42 mg monensin/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/head/day and 60 to 90 mg/head/day tylosin. The melengestrol acetate portion of this Type C medicated feed must be mixed into the complete feed containing 10 to 40 g/ton monensin and 8 to 10 g/ton tylosin at feeding into the amount of complete feed consumed by an animal per day.

Oral

MGA® and Monovet® and Tylovet®

Heifers fed in confinement for slaughter

Feed continuously as sole ration containing 9.8 to 24.6 g/ton ractopamine hydrochloride to provide 90 to 430 mg/head/day ractopamine hydrochloride; 10 to 40 g/ton monensin to provide 0.14 to 0.42 mg monensin/lb of body weight per day, depending on severity of coccidiosis challenge, up to 480 mg/head/day; 8 to 10 g/ton tylosin to provide 60 to 90 mg/head/day tylosin for the last 28 to 42 days on feed. Mix or top dress with medicated feed containing 0.125 to 1.0 mg melengestrol acetate per pound fed at the rate of 0.5 to 2.0 lb/head/day to provide 0.25 to 0.5 mg melengestrol acetate per head per day for the last 28 to 42 days on feed.

Oral

Optigrid® and Monovet® and Tylovet® and CycleGuard®

Heifers fed in confinement for slaughter

0.125 to 1.0 mg/lb of MGA® for increased rate of weight gain, improved feed efficiency and suppression of estrus (heat) in heifers fed in confinement for slaughter. Must be top dressed or mixed with a complete ration containing monensin (10 to 40 g/ton), tylosin (8 to 10 g/ton) and ractopamine (9.8 to 24.6 g/ton). Feed at the rate of 0.5-2.0 pound(s) per head per day (specify one level) to provide 0.25-0.5 mg melengestrol acetate per head per day (specify one level). Feed melengestrol acetate in this combination for the final 28 to 42 days on feed.

Oral

Optaflexx™ and Monovet® and Tylan™ and MGA®

Heifers fed in confinement for slaughter

0.125 to 1.0 mg/lb of MGA®. Must be top dressed or mixed with a complete ration containing monensin (10 to 40 g/ton), tylosin (8 to 10 g/ton) and ractopamine (9.8 to 24.6 g/ton). Feed at the rate of 0.5-2.0 pound(s) per head per day (specify one level) to provide 0.25-0.5 mg melengestrol acetate per head per day (specify one level). Feed melengestrol acetate in this combination for the final 28 to 42 days on feed.

Oral

Optaflexx™ and Monovet® and Tylovet® and MGA®

Heifers fed in confinement for slaughter

9.8 to 24.6 g/ton of Optaflexx™, 10 to 40 g/ton of Monovet®, and 8 to 10 g/ton of Tylovet®. Feed continuously as sole ration to provide 90 to 430 mg/hd/day ractopamine and 0.14 to 0.42 mg monensin/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/hd/day and 60 to 90 mg/hd/day tylosin for the last 28 to 42 days on feed.

Oral

Optaflexx™ and Monovet® and Tylovet® and MGA®

Heifers fed in confinement for slaughter

0.125 to 1.0 mg/lb fed at the rate of 0.5 to 2.0 lb/head/day (specify one level) to provide 0.25 to 0.5 mg/head/day (specify one level) of melengestrol acetate (as MGA®). Feed continuously as sole ration for the final 28 to 42 days on feed.

Oral

Optigrid® and Monovet® and Tylovet® and MGA®

Heifers fed in confinement for slaughter

10 to 40 g/ton to provide 0.14 to 0.42 mg/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480mg/head/day, of monensin (as Monovet®). Feed continuously as sole ration for the final 28 to 42 days on feed.

Oral

Optigrid® and Monovet® and Tylovet® and MGA®

Heifers fed in confinement for slaughter

9.8 to 24.6 g/ton to provide 90 to 430 mg/head/day of ractopamine hydrochloride (as Optigrid®). Feed continuously as sole ration for the final 28 to 42 days on feed.

Oral

Optigrid® and Monovet® and Tylovet® and MGA®

Heifers fed in confinement for slaughter

8 to 10 g/ton to provide 60 to 90 mg/head/day of tylosin phosphate (as Tylovet®). Feed continuously as sole ration for the final 28 to 42 days on feed.

Oral

Optigrid® and Monovet® and Tylovet® and MGA®

Heifers fed in confinement for slaughter

Administer 1 implant per anima

Subcutaneous

Implant subcutaneously in ear only. Do not use in animals intended for subsequent breeding or in dairy animals. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component™ TE-H with Tylan™

Growing beef heifers fed in confinement for slaughter

0.25 to 2 g/ton of melengestrol acetate (as MGA® 200 or MGA® 500) to provide 0.25 to 0.5 mg melengestrol acetate per head per day, 1.25 to 4.54 g/ton of lubabegron (as lubabegron fumarate) (as Experior™) to provide 13 to 90 mg lubabegron per head per day, 10 to 40 g/ton of monensin (as Rumensin™) to provide 0.14 to 0.42 mg monensin per pound of body weight per day, depending upon severity of challenge, up to a maximum of 480 mg monensin per head per day, and 8 to 10 g/ton of tylosin (as tylosin phosphate) (as Tylan™) to provide 60 to 90 mg tylosin per head per day. The melengestrol acetate Type C top-dress medicated feed (0.5 to 2 lb(s) per head per day) must be top dressed onto or mixed at feeding with a Type C medicated feed containing lubabegron and monensin and tylosin. Feed as the sole ration during the last 14 to 91 days on feed.

Oral

MGA® and Experior™ and Rumensin™ and Tylan™

Growing beef heifers fed in confinement for slaughter

Administer one implant containing 80 mg trenbolone acetate, 8 mg estradiol, and 29 mg tylosin tartrate (5 pellets) to each steer or heifer by subcutaneous implantation in the middlethird of the ear.

Subcutaneous

Component™ TE-IH with Tylan™

Cattle (heifers fed in confinement for slaughter

Melengestrol acetate (0.25 to 2 g/ton) in combination with monensin (10 to 40 g/ton) and tylosin (8 to 10 g/ton).

Oral

Feed continuously as sole ration to heifers at a rate of 0.5 to 2.0 pounds per head per day to provide 0.25 to 0.5 mg/head/day melengestrol acetate and 0.14 to 0.42 mg monensin/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/head/day and 60 to 90 mg/head/day tylosin. The melengestrol acetate portion of this Type C medicatedfeed must be mixed into the complete feed containing 10 to 40 g/ton monensin and 8 to 10 g/ton tylosin at feeding into the amount of complete feed consumed by an animal per day.Melengestrol acetate is for use only in heifers being fed in confinement for slaughter. Not effective in steers or spayed heifers. Heifers fed in confinement for slaughter: Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at the time of loading.Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle and goat feed is safe for use in cattle and goats only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing.Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

MGA® and Rumensin™ and Tylan™

Cattle (Beef and Non-lactating Dairy)

Administer 8 mg per pound of body weight (1 mL per 25 pounds) by intramuscular injection once daily.

Intramuscular

Do not inject more than 10 mL per site. Use a 50 mg/mL solution for calves weighing less than 200 pounds. Cattle intended for human consumption must not be slaughtered within 21 days of the last use of this drug product. This drug is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. This product is not approved for use in calves intended to be processed for veal. A withdrawal period has not been established in pre-ruminating calves.

BiloVet®

Cattle (Beef and Non-lactating Dairy)

8 mg per pound of body weight one time daily (1 mL per 25 pounds); not to exceed 5 days.

Intramuscular

Do not mix Tylan 200 Injection with other injectable solutions as this may cause a precipitation of the active ingredients. Adverse reactions, including shock and death may result from overdosage in baby pigs. Do not attempt injection into pigs weighing less than 25 pounds (0.5 mL) with the common syringe. It is recommended that Tylan 50 Injection be used in pigs weighing less than 25 pounds. Do not administer to horses or other equines. Injection of tylosin in equines has been fatal.

Tylan™ 200 Injection

Beef calves 45 days of age and older and weighing up to 400 lbs

Administer one implant containing 100 mg progesterone, 10 mg estradiol benzoate, and 29 mg tylosin tartrate (5 pellets) to each calf by subcutaneous implantation in the middle-third of the ear

Subcutaneous

Component™ E-C with Tylan™

Cattle (suckling beef calves)

100 milligrams progesterone and 10 milligrams estradiol benzoate (one implant consisting of 4 pellets, each pellet containing 25 milligrams progesterone and 2.5 milligrams estradiol benzoate) per implant dose.

Subcutaneous

For use in suckling beef calves (at least 45 days of age) up to 400 pounds of body weight. For subcutaneous ear implantation, one dose per animal. Do not use in bull calves intended for reproduction. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Component™ E-S with Tylan™

Growing beef steers weighing 400 lbs or more

Administer 1 implant —the entire contents of one cartridge cell (9 pellets) subcutaneously in the back of the middle third of the ear.

Subcutaneous

Component™ E-S with Tylan™

Growing beef heifers weighing 400 lbs or more

Administer 1 implant --the entire contents of one cartridge cell (9 pellets) – subcutaneously in the back of the middle third of the ear.

Subcutaneous

Component™ E-H with Tylan™

Cattle (Heifer)

Melengestrol acetate (0.125 to 1. 0 mg/lb is top dressed or mixed with a complete ration containing monensin (10 to 40 g/ton), tylosin (8 to 10 g/ton), and zilpaterol (6.8 g/ton).

Oral

Feed continuously as the sole ration for the final 20 to 40 days. Do not use in calves to be processed for veal. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feeds is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Zilpaterol hydrochloride is not for use in animals intended for breeding. Do not allow horses or other equines access to feed containing zilpaterol. Do not use in veal calves. Not to be fed to cattle in excess of 90 mg zilpaterol/head/day in complete feed. If pen consumption of complete feed exceeds 26.5 lb/head/day (90% dry matter basis), zilpaterol should not be fed in complete feed. Melengestrol acetate is not effective in steers and spayed heifers. Withdrawal periods of three to five days or more should be avoided to prevent the possibility that the heifers may come into estrus (heat) at loading time. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Special considerations: 1) For liquid melengestrol acetate Type C feeds stored in recirculation tank systems, labeling indicates: “Recirculate immediately prior to use for no less than 10 minutes, moving not less than 1 percent of the tank contents from the bottom of the tank to the top. Recirculate daily, as directed in this paragraph even when the Type C feed is not used.” For liquid melengestrol Type C feeds stored in mechanical, air or other agitation-type tank systems: “Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily, as directed in this paragraph, even when the Type C feed is not used.” 2) All labeling for Type C feeds containing zilpaterol hydrochloride provides the warning: The active ingredient in Zilmax® is zilpaterol hydrochloride, a beta2-adrenergic agonist. Not for use in humans. An anti-dust process has been applied to the drug product, Zilmax®, in order to greatly reduce inhalation risk. Extended handling tasks with the potential for dust generation require respiratory protection. Wear appropriate skin protection (e.g., impervious gloves, apron, overalls), if there is a potential for extended skin contact. Wear protective eyewear, if there is a potential for eye contact. If accidental eye contact occurs, immediately rinse with water and consult a physician.

Heifermax® 500/Zilmax®/Rumensin®/Tylan®

Beef cattle

8 to 10 g/ton of tylosin (0.08 to 0.10 lbs of Tylovet 100) to be fed so that each animal receives not more than 90 mg per head per day and not less than 60 mg per head per day. Feed continuously as the sole ration.

Oral

Tylovet® 40

Cattle, Beef, Heifers fed in confinement for slaughter

Melengestrol acetate is added to the diet of heifers at 0.5 to 2.0 pounds per head per day of medicated feed containing 0.125 to 1.0 mg melengestrol acetate per pound to provide 0.25 to 0.5 mg melengestrol acetate per head per day. Monensin is added to feedlot cattle diets at concentrations of 10 to 40 g of monensin per ton of complete feed at a rate of 0.14 mg to 0.42 mg monensin per pound of body weight depending on the severity of coccidiosis challenge up to 480 mg per head per day. Tylosin is added to the cattle diets at concentrations of 8 to 10 g of tylosin phosphate per ton of complete feed to provide 60 to 90 mg tylosin per head per day.

Oral

Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle and goat feed is safe for use in cattle and goats only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Feed only to cattle being fed in confinement for slaughter. Feed continuously as sole ration. A withdrawal time has not been established in pre-ruminating calves. Do not use in calves to be processed for veal.

MGA®, Rumensin™ and Tylovet® 100

Cattle, Beef, Heifers fed in confinement for slaughter

Feed continuously as sole ration containing 9.8 to 24.6 g/ton ractopamine to provide 90 to 430 mg/hd/day ractopamine; 10 to 40 g/ton monensin to provide 0.14 to 0.42 mg monensin/lb of body weight per day, depending on severity of coccidiosis challenge, up to 480 mg/head/day; 8 to 10 g/ton tylosin to provide 60 to 90 mg/head/day tylosin for the last 28 to 42 days on feed. Mix or top dress with medicated feed containing 0.125 to 1.0 mg melengestrol acetate per pound fed at the rate of 0.5 to 2.0 lb/head/day to provide 0.25 to 0.5 mg melengestrol acetate per head per day for the last 28 to 42 days on feed.

Oral

Melengestrol acetate is not effective in steers and spayed heifers. Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at time of loading. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Ractopamine HCl is not for animals intended for breeding. Special considerations: Mixing directions for liquid melengestrol acetate Type C feeds stored in recirculation tank systems, labeling indicates: “Recirculate immediately prior to use for no less than 10 minutes, moving not less than 1 percent of the tank contents from the bottom of the tank to the top. Recirculate daily, as directed in this paragraph even when the Type C feed is not used.” For liquid melengestrol Type C feeds stored in mechanical, air or other agitation-type tank systems: “Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily, as directed in this paragraph, even when the Type C feed is not used.”

Optaflexx™ 45/Rumensin®/Tylovet® 100/MGA®

Cattle, Beef, Heifers fed in confinement for slaughter

Melengestrol acetate (0.25 to 2 g/ton) in combination with monensin (10 to 40 g/ton) and tylosin (8 to 10 g/ton).

Oral

Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Feed continuously as sole ration to heifers at a rate of 0.5 to 2.0 pounds per head per day to provide 0.25 to 0.5 mg/head/day melengestrol acetate and 0.14 to 0.42 mg monensin/lb body weight per day, depending on the severity of the coccidiosis challenge, up to 480 mg/head/day and 60 to 90 mg/head/day tylosin. The melengestrol acetate portion of this Type C medicated feed must be mixed into the complete feed containing 10 to 40 g/ton monensin and 8 to 10 g/ton tylosin at feeding into the amount of complete feed consumed by an animal per day. Melengestrol acetate is for use only in heifers being fed in confinement for slaughter. Not effective in steers or spayed heifers. Heifers fed in confinement for slaughter: Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at the time of loading. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle and goat feed is safe for use in cattle and goats only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

MGA®, Rumensin™ and Tylovet® 100

Cattle, Beef heifers fed in confinement for slaughter

Ractopamine is fed at concentrations of 9.8 to 24.6 g of ractopamine hydrochloride per ton of complete feed (based on 90% dry matter basis) to provide 90 to 430 mg ractopamine/head/day in cattle fed in confinement for slaughter during the last 28 to 42 days on feed. Monensin is added to feedlot cattle diets at concentrations of 10 to 40 g of monensin USP per ton of complete feed at a rate of 0.14 to 0.42 mg monensin/lb of body weight, depending on severity of coccidiosis challenge, up to 480 mg/head/day. Tylosin is added to the cattle diets at concentrations of 8 to 10 g of tylosin phosphate per ton of complete feed to provide 60 to 90 mg tylosin/head/day. Melengestrol acetate is added to the diet of heifers at 0.5 to 2.0 pounds per head per day of medicated feed containing 0.125 to 1.0 mg melengestrol acetate per pound to provide 0.25 to 0.5 mg melengestrol acetate/head/day in heifers being fed for slaughter.

Oral

Feed continuously as sole ration during the last 28 to 42 days on feed. Not for animals intended for breeding. Do not use in calves to be processed for veal.Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Actogain™ 45/Rumensin®/Tylan®/MGA®

Cattle, Beef fed in confinement for slaughter

Ractopamine hydrochloride top dress (not to exceed 800 g/ton) to be fed with a ration containing 10 to 40 g/ton monensin in combination with 8 to 10 g/ton tylosin phosphate.

Oral

Feed continuously as sole ration during the last 28 to 42 days on feed. Do not use in calves to be processed for veal. Ractopamine HCl is not for animals intended for breeding. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Actogain™ 45/Rumensin®/Tylovet® 100

Cattle, Beef fed in confinement for slaughter

Ractopamine hydrochloride (8.2 to 24.6 g/ton) in combination with monensin USP (10 to 40 g/ton) and tylosin phosphate (8 to 10 g/ton).

Oral

Feed continuously as sole ration to provide 70 to 430 mg ractopamine per hd/day and 0.14 to 0.42 mg monensin per lb body weight/day (depending on severity of coccidiosis challenge, up to 480 mg/hd/day), and 60 to 90 mg tylosin per hd/day for the last 28 to 42 days on feed. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Ractopamine HCl is not for animals intended for breeding. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Optaflexx™ 45/Rumensin®/Tylovet® 100

Cattle (Heifers)

Melengestrol acetate, 0.25 to 0.50 milligram per head per day, plus lasalocid (as lasalocid sodium), 100 to 360 milligrams per head per day, and tylosin (as tylosin phosphate), 90 milligrams per head per day. To attain this amount: Add 0.5 to 2.0 pounds per head per day of a liquid or dry medicated feed containing 0.125 to 1.0 milligram of melengestrol acetate per pound to a medicated feed containing 10 to 30 grams of lasalocid and 8 to 10 grams of tylosin per ton; or Add 0.5 to 2.0 pounds per head per day of a liquid or dry medicated feed containing 0.125 to 1.0 milligram of melengestrol acetate per pound plus 50 to 720 milligrams of lasalocid per pound to 4.5 to 18 pounds of a dry medicated feed containing 10 to 40 grams of tylosin per ton; or Add 0.5 to 2.0 pounds per head per day of a dry pelleted medicated feed containing 0.125 to 1.0 milligram of melengestrol acetate (from a dry Type A article), 50 to 720 milligrams of lasalocid, and 45 to 180 milligrams of tylosin per pound to a ration of non-medicated feed.

Oral

For heifers being fed in confinement for slaughter.

Bovatec® / MGA® 100 / Tylan®

Cattle (beef and nonlactating dairy)

8 milligrams per pound of body weight intramuscularly, once daily.

Intramuscular

Treatment should be continued 24 hours after symptoms of the disease have stopped, not to exceed 5 days. Continue treatment 24 hours after symptoms disappear. Do not inject more than 10 milliliters per site. Do not use in lactating dairy cattle. Use a 50-milligram-per-milliliter solution for calves weighing less than 200 pounds. Do not administer within 21 days of slaughter. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Tylovet® 200 mg/mL Injection

Beef steers and heifers fed in confinement for slaughter

1.25 to 4.54 g/ton to provide 13 to 90 mg/hd/day of lubabegron (as Experior™), 10 to 40 g/ton to provide 0.14 to 0.42 mg/lb body weight per day, depending upon severity of coccidiosis challenge, up to 480 mg/hd/day, ofmonensin (as Monovet®), and 8 to 10 g/ton to provide 60 to 90 mg/hd/day of tylosin (as Tylovet®). Feed continuously as the sole ration during the last 14 to 91 days on feed.

Oral

Experior™ and Monovet® and Tylovet®

Beef steers and heifers fed in confinement for slaughter

1.25 to 4.54 g/ton to provide 13 to 90 mg/hd/day of Experior™; 10 to 40 g/ton to provide 0.14 to 0.42 mg/lb body weight per day, depending upon severity of coccidiosis challenge, up to 480 mg/hd/day, of Rumensin™; and 8 to 10 g/ton to provide 60 to 90 mg/hd/day of Tylan™ Feed continuously as sole ration during the last 14 to 91 days on feed.

Oral

Experior™ and Rumensin™ and Tylan™

Beef steers and heifers fed in confinement for slaughter

1.25 to 4.54 g/ton to provide 13 to 90 mg/hd/day of lubabegron (as Experior™), 5 to 40 g/ton to provide 50 to 480 mg/hd/day of monensin (as Monovet®), and 8 to 10 g/ton to provide 60 to 90 mg/hd/day of tylosin (as Tylovet®). Feed continuously as the sole ration during the last 14 to 91 days on feed.

Oral

Experior™ and Monovet® and Tylovet®

Beef steers and heifers fed in confinement for slaughter

1.25 to 4.54 g/ton to provide 13 to 90 mg/hd/day of Experior™; 5 to 40 g/ton to provide 50 to 480 mg/hd/day of Rumensin™; and 8 to 10 g/ton to provide 60 to 90 mg/hd/day of Tylan™. Feed continuously as sole ration during the last 14 to 91 days on feed.

Oral

Experior™ and Rumensin™ and Tylan™

4.5 to 9 g/ton ractopamine hydrochloride and 40 to 100 g/ton tylosin (as tylosin phosphate) per ton of Type C medicated feed. No increased benefit has been shown when ractopamine hydrochloride concentrations in the diet are greater than 4.5 g/ton (5 ppm). Feed as the sole ration to finishing swine weighing at least 150 lbs for the last 45 to 90 lbs (group average) of weight gain prior to slaughter. Feed 40 to 100 grams of tylosin per ton of complete feed for 2 to 6 weeks immediately after medicating with tylosin in drinking water (250 mg tylosin per gallon) for 3 to 10 days. Ractopamine hydrochloride use may increase the number of injured, lame, and/or fatigued pigs during marketing. Behavioral signs such as hyperactivity, anxiety, and aggression have been reported in pigs fed ractopamine hydrochloride. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

Oral

Paylean™ and Tylovet®

4.5 to 9 g/ton ractopamine hydrochloride and 40 or 100 g/ton tylosin (as tylosin phosphate) per ton of Type C medicated feed. No increased benefit has been shown when ractopamine hydrochloride concentrations in the diet are greater than 4.5 g/ton (5 ppm). Feed as the sole ration to finishing swine weighing at least 150 lbs for the last 45 to 90 lbs (group average) of weight gain prior to slaughter. Feed 100 g of tylosin per ton of complete feed for at least three weeks, followed by 40 g tylosin per ton of complete feed until pigs reach market weight. Ractopamine hydrochloride use may increase the number of injured, lame, and/or fatigued pigs during marketing. Behavioral signs such as hyperactivity, anxiety, and aggression have been reported in pigs fed ractopamine hydrochloride. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

Oral

Paylean™ and Tylovet®

For the treatment and control of swine dysentery medicate with 250 mg tylosin per gallon in drinking water for 3 to 10 days, depending upon severity of infection. Alternatively, medicate with 250 mg tylosin per gallon in drinking water for 3 to 10 days, followed by 40 to 100 g of tylosin per ton of complete feed (Type C medicated feed manufactured from tylosin phosphate Type A medicated article) for 2 to 6 weeks. For control of porcine proliferative enteropathies (PPE, ileitis) medicate with 250 mg tylosin per gallon in drinking water for 3 to 10 days, followed by 40 to 100 g of tylosin per ton of complete feed (Type C medicated feed manufactured from tylosin phosphate Type A medicated article) for 2 to 6 weeks. Swine must consume enough medicated water to provide a therapeutic dose.

Oral

Only medicated water (250 mg tylosin per gallon) should be available while medicating with BiloVet. Swine must not be slaughtered for food within 48 hours after treatment.

BiloVet®

250 mg/gallon (66 ppm) in drinking water. Swine dysentery: Administer medicated drinking water for 3 to 10 days, depending upon severity of infection. Alternatively, administer medicated drinking water for 3 to 10 days, followed by 40 to 100 g tylosin per ton of complete feed (Type C medicated feed manufactured from Tylovet Type A medicated article) for 2 to 6 weeks. Only medicated water should be available to swine while medicating with Tylovet Soluble. Porcine proliferative enteropathies: Administer medicated drinking water for 3 to 10 days, followed by 40 to 100 g of tylosin per ton of complete feed (Type C medicated feed manufactured from Tylovet A medicated article) for 2 to 6 weeks. Only medicated water should be available to swine while medicating with Tylovet Soluble.

Oral

Tylovet® Soluble

Feed 100 g of tylosin per ton (1.0 pound Tylovet 100 per ton) of complete feed for 21 days. Alternatively, feed 100 g of tylosin per ton (1.0 pound Tylovet 100 per ton) of complete feed for at least three weeks, followed by 40 g tylosin per ton of complete feed until pigs reach market weight. Alternatively, feed 40 to 100 grams of tylosin (0.4 to 1.0 pounds of Tylovet 100) per ton of complete feed for 2 to 6 weeks immediately after medicating with 250 mg tylosin (as Tylovet Soluble) per gallon in drinking water for 3 to 10 days. Feed continuously as the sole ration when feeding Tylovet.

Oral

Tylovet® 40

Feed 100 g of tylosin per ton (2.5 pounds Tylan 40 per ton) of complete feed for 21 days. Alternatively, feed 100 g of tylosin per ton (2.5 pounds Tylan 40 per ton) of complete feed for at least three weeks, followed by 40 g tylosin per ton of complete feed until pigs reach market weight. Alternatively, feed 40 to 100 grams of tylosin (1.0 to 2.5 pounds of Tylan 40) per ton of complete feed for 2 to 6 weeks immediately after medicating with 250 mg tylosin (as Tylan Soluble) per gallon in drinking water for 3 to 10 days. Feed as the sole ration when feeding Tylan.

Oral

Tylan® 40

Administer 4 mg per pound of body weight (1 mL per 50 pounds) by intramuscular injection twice daily for not more than 3 consecutive days. Continue treatment 24 hours after symptoms disappear. If tylosin medicated drinking water is used as a follow-up treatment for swine dysentery, the animal should thereafter receive feed containing 40 to 100 grams of tylosin per ton for 2 weeks to assure depletion of tissue residues.

Intramuscular

Do not inject more than 5 mL per site. Adverse reactions, including shock and death may result from overdosage in baby pigs. It is recommended that tylosin 50 mg/mL injection be used in pigs weighing less than 25 lbs. Swine intended for human consumption must not be slaughtered within 14 days of the last use of this drug product.

BiloVet®

12 grams per ton of Hygromycin B in combination with 10-100 grams per ton of Tylosin. Up to 40 pounds body weight- 20 to 100 tylosin grams per ton of feed. 41 to 100 pounds body weight- 20 to 40 tylosin grams per ton of feed. 101 to market weight pounds body weight- 10 to 20 tylosin grams per ton of feed.

Oral

As tylosin phosphate. Feed continuously.

Tylosin® / Hygromix

For the treatment and control of swine dysentery. Feed 40 to 100 grams of tylosin (1.0 to 2.5 pounds of Tylan 40) per ton of complete feed for 2 to 6 weeks immediately after medicating with 250 mg tylosin (as Tylan Soluble) per gallon in drinking water for 3 to 10 days.

Oral

Tylan® 40

4.5 to 9 g/ton ractopamine hydrochloride and 40 or 100 g/ton tylosin (as tylosin phosphate) per ton of Type C medicated feed. No increased benefit has been shown when ractopamine hydrochloride concentrations in the diet are greater than 4.5 g/ton (5 ppm).

Oral

Feed as the sole ration to finishing swine weighing at least 150 lbs for the last 45 to 90 lbs (group average) of weight gain prior to slaughter. Feed 100 g of tylosin per ton of complete feed for at least three weeks, followed by 40 g tylosin per ton of complete feed until pigs reach market weight. Ractopamine hydrochloride use may increase the number of injured, lame, and/or fatigued pigs during marketing. Behavioral signs such as hyperactivity, anxiety, and aggression have been reported in pigs fed ractopamine hydrochloride. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

Paylean™ and Tylan™

Feed 40 to 100 g of tylosin (0.4 to 1.0 pounds of Tylovet 100) per ton of complete feed for 2 to 6 weeks immediately after medicating with 250 mg tylosin (as Tylovet Soluble) per gallon in drinking water for 3 to 10 days.

Oral

Tylovet® 40

Feed 100 g of tylosin per ton (1.0 pound Tylovet 100 per ton) of complete feed for at least three weeks. Follow with 40 g tylosin per ton (0.4 pound Tylovet 100 per ton) of complete feed until pigs reach market weight.

Oral

Tylovet® 40

Feed 100 g of tylosin per ton (2.5 pounds Tylan 40 per ton) of complete feed for at least three weeks. Follow with 40 g tylosin per ton (1 pound Tylan 40 per ton) of complete feed until pigs reach market weight.

Oral

Tylan® 40

Tylosin, 10- 100 grams per ton of feed. Pre-starter or starter: 20- 100 grams per ton. Grower: 20- 40, grower grams per ton. Finisher: 10- 20, finisher grams per ton.

Oral

As tylosin phosphate. Continuous use.

Moormaboost TY 4000 Medicated

Tylosin, 10-100 grams per ton of feed. Pre-starter or starter ration: 20-100 grams per ton. Grower ration: 20-40 grams per ton. Finisher ration: 10-20 grams per ton.

Oral

Continuous use.

Quali-Tech Tylan®-10 Premix

Tylosin, 10-100 grams per ton of feed. Continuous use as follows: Grams per ton: 20-100, prestarter or starter; 20-40, grower; 10-20, finisher.

Oral

Purina® Hog Plus II

Tylosin, 40 or 100 grams per ton of feed. Use 100 grams per ton for at least 3 weeks followed by 40 grams per ton until market weight.

Oral

Purina® Hog Plus II

Feed 100 g of tylosin per ton (1.0 pound Tylovet 100 per ton) of complete feed. Feed continuously as the sole ration.

Oral

Tylovet® 40

96 grams (0.0106 percent) pyrantel tartrate and 40 or 100 grams tylosin per ton of Type C medicated feed.

Oral

Feed 40 or 100 g of tylosin per ton of complete feed continuously as the sole ration for 2 to 6 weeks after treatment with tylosin in drinking water (250 mg tylosin per gallon) for 3 to 10 days. Do not use in any finished feed (supplement, concentrate or complete feed) containing bentonite. Withdraw 24 hours prior to slaughter.

Tylan™ and Banminth®

4 mg per pound of body weight (1 mL per 12.5 pounds) twice daily; not to exceed 3 days.

Intramuscular

Do not mix Tylan 50 Injection with other injectable solutions as this may cause a precipitation of the active ingredients. Adverse reactions, including shock and death, may result from overdosage in baby pigs. Do not attempt injection into pigs weighing less than 6.25 pounds (0.5 mL) unless the syringe is capable of accurately delivering 0.1 mL. Do not administer to horses or other equines. Injection of tylosin in equines has been fatal.

Tylan™ 50 Injection

Tylosin, 100 grams per ton of feed plus sulfamethazine, 100 grams per ton of feed.

Oral

Tylan® 5 Sulfa Premix

100 grams tylosin per ton of feed plus 100 grams sulfamethazine per ton of feed.

Oral

Withdraw 15 days before swine are slaughtered. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Tylan® 10 Sulfa-G™

4 milligrams per pound of body weight intramuscularly, twice daily.

Intramuscular

Treatment should be continued 24 hours after symptoms of the disease have stopped, not to exceed 3 days. Continue treatment 24 hours after symptoms disappear. Do not inject more than 5 milliliters per site. Do not administer within 14 days of slaughter. If tylosin medicated drinking water is used as followup treatment for swine dysentery, the animal should thereafter receive feed containing 40 to 100 grams of tylosin per ton for 2 weeks to assure depletion of tissue residues.

Tylovet® 200 mg/mL Injection

Tylosin phosphate (100 g/ton) plus sulfamethazine (100 g/ton).

Oral

Withdraw 15 days before swine are slaughtered.

Tylan™ 5 Sulfa-G™

For reduction in severity of effects of atrophic rhinitis.

Oral

Tylan® 40

Tylosin, 100 grams plus sulfamethazine, 100 grams.

Oral

As tylosin phosphate. Withdraw 15 days before slaughter.

Seeco Tylan®-Sulfa 10 Premix Med.

250 mg/gallon (66 ppm) in drinking water.

Oral

Only medicated water should be available to swine while medicating with Tylan Soluble.

Tylan Soluble™

Tylosin, 40- 100 grams per ton of feed.

Oral

Administer in feed as tylosin phosphate after treatment with tylosin in drinking water as tylosin base; 0.25 gram per gallon in drinking water for 3- 10 days, 40- 100 grams per ton in feed for 2- 6 weeks.

Tylan® 10 Premix

40 to 100 grams per ton of feed.

Oral

Administer as tylosin phosphate in feed for 2 to 6 weeks, immediately after treatment with tylosin tartrate in drinking water at 250 milligrams per gallon in drinking water for 3 to 10 days.

TYLAN™ 20

Tylosin, 40-100 grams per ton.

Oral

Administer as tylosin phosphate in feed for 2 to 6 weeks, immediately after treatment with tylosin tartrate in drinking water.

Purina® Hog Plus II

100 grams per ton of feed.

Oral

As tylosin phosphate. Administer for 21 days.

TYLAN™ 20

Finishing Swine

4.5 to 9 g/ton ractopamine hydrochloride and 40 to 100 g/ton tylosin (as tylosin phosphate) per ton of Type C medicated feed. No increased benefit has been shown when ractopamine hydrochloride concentrations in the diet are greater than 4.5 g/ton (5 ppm). Feed as the sole ration to finishing swine weighing at least 150 lbs for the last 45 to 90 lbs (group average) of weight gain prior to slaughter. Feed 40 to 100 grams of tylosin per ton of complete feed for 2 to 6 weeks immediately after medicating with tylosin in drinking water (250 mg tylosin per gallon) for 3 to 10 days. Ractopamine hydrochloride use may increase the number of injured, lame, and/or fatigued pigs during marketing. Behavioral signs such as hyperactivity, anxiety, and aggression have been reported in pigs fed ractopamine hydrochloride. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

Oral

Engain™ and Tylan™

Finishing Swine

4.5 to 9 g/ton ractopamine hydrochloride and 40 or 100 g/ton tylosin (as tylosin phosphate) per ton of Type C medicated feed. No increased benefit has been shown when ractopamine hydrochloride concentrations in the diet are greater than 4.5 g/ton (5 ppm). Feed as the sole ration to finishing swine weighing at least 150 lbs for the last 45 to 90 lbs (group average) of weight gain prior to slaughter. Feed 100 g of tylosin per ton of complete feed for at least three weeks, followed by 40 g tylosin per ton of complete feed until pigs reach market weight. Ractopamine hydrochloride use may increase the number of injured, lame, and/or fatigued pigs during marketing. Behavioral signs such as hyperactivity, anxiety, and aggression have been reported in pigs fed ractopamine hydrochloride. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

Oral

Engain™ and Tylan™

Broiler Chickens

Tylosin, 800- 1000 grams per ton of feed. Administer in feed to chickens 0 to 5 days of age, follow with second administration in feed for 24- 48 hours at 3 to 5 weeks of age.

Oral

As tylosin phosphate. Withdraw 5 days before slaughter.

Tylan® 10 Premix

Broiler Chickens

Monensin, 90 to 110 grams, plus tylosin phosphate, 4 to 50 grams per ton.

Oral

Feed continuously as sole ration. In the absence of coccidiosis, the use of monensin with no withdrawal period may limit feed intake resulting in reduced weight gain. Do not feed to laying chickens. Do not allow horses or other equines access to formulations containing monensin. Ingestion of monensin by equines has been fatal. Must be thoroughly mixed in feeds before use. Do not feed undiluted.

Coban® / Tylan®

Broiler Chickens

Narasin, 54 to 72 grams, plus tylosin, 4 to 50 grams per ton

Oral

For broiler chickens only. Feed continuously as sole ration. Do not allow adult turkeys, horses, or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal.

Monteban® / Tylan®

Broiler Chickens

Tylosin - 4 to 50 g/ton Salinomycin - 40 to 60 g/ton

Oral

For broiler chickens only. Do not feed to laying hens. Not approved for use with pellet binders. May be fatal if accidentally fed to adult turkeys or horses.

Tylan® / Bio-Cox®

Chickens (broilers)

Tylosin, 800- 1000 grams per ton of feed. Administer in feed to chickens 0 to 5 days of age, follow with second administration in feed for 24- 48 hours at 3 to 5 weeks of age.

Oral

As tylosin phosphate. Withdraw 5 days before slaughter.

Tylan® 10 Premix

2,000 mg/gallon (528 ppm) in drinking water. Administer medicated drinking water for three days; however, medicated water may be administered for one to five days depending upon severity of infection. Treated chickens must consume enough medicated water to provide 50 mg per pound of body weight per day. Only medicated water should be available to the birds.

Oral

Tylovet® Soluble

851 to 1,419 mg/gallon (225 to 375 ppm) in drinking water. Administer medicated drinking water for a single five day period in broiler chickens. To assure all birds receive the intended medication, only medicated water should be available.

Oral

Tylovet® Soluble

8-12 grams per ton of Hygromycin B in combination with 4-50 grams per ton of Tylosin.

Oral

As tylosin phosphate.

Hygromix-Tylan® Premix

851 to 1,419 mg/gallon (225 to 375 ppm) in drinking water.

Oral

Only medicated water should be available to the birds.

Tylan Soluble™

2,000 mg/gallon (528 ppm) in drinking water.

Oral

Only medicated water should be available to the birds.

Tylan Soluble™

Tylosin, 4- 50 grams per ton of feed.

Oral

As tylosin phosphate.

Tylan® 10 Premix

4-50 grams Tylosin per ton of feed.

Oral

As tylosin phosphate.

Tylan® Premix No.10

4-50 grams per ton of feed.

Oral

Gilt Edge Tylan® Mix

Chickens (laying)

Tylosin, 20- 50 grams per ton of feed.

Oral

As tylosin phosphate.

Tylan® 10 Premix

Chickens (laying)

20-50 grams Tylosin per ton of feed.

Oral

As tylosin phosphate.

Tylan® Premix No.10

Chickens (laying)

20- 50 grams per ton of feed.

Oral

Gilt Edge Tylan® Mix

Chickens (replacements)

Tylosin, 1,000 grams per ton of feed. Administer in feed to chickens 0 to 5 days of age, follow with second administration in feed for 24 to 48 hours at 3 to 5 weeks of age.

Oral

As tylosin phosphate. Withdraw 5 days before slaughter.

Tylan® 10 Premix

Chickens (Replacements)

Tylosin, 1,000 grams per ton of feed. Administer in feed to chickens 0 to 5 days of age, follow with second administration in feed for 24 to 48 hours at 3 to 5 weeks of age.

Oral

As tylosin phosphate. Withdraw 5 days before slaughter.

Hy-Con Tylan® Premix

Chickens (Broilers)

Tylosin, 800- 1000 grams per ton of feed. Administer in feed to chickens 0 to 5 days of age, follow with second administration in feed for 24- 48 hours at 3 to 5 weeks of age.

Oral

As tylosin phosphate. Withdraw 5 days before slaughter.

Hy-Con Tylan® Premix

Chickens (Layers)

Tylosin, 20- 50 grams per ton of feed.

Oral

As tylosin phosphate.

Hy-Con Tylan® Premix

Replacement Chickens

Tylosin, 1,000 grams per ton of feed. Administer in feed to chickens 0 to 5 days of age, follow with second administration in feed for 24 to 48 hours at 3 to 5 weeks of age.

Oral

As tylosin phosphate. Withdraw 5 days before slaughter.

Tylan® 10 Premix

Laying Chickens

Tylosin, 20- 50 grams per ton of feed.

Oral

As tylosin phosphate.

Tylan® 10 Premix

Chickens (Laying)

Tylosin, 20-50 grams per ton of feed.

Oral

As tylosin phosphate.

Tylan® 5 Premix

Chickens (broiler)

Tylosin, 800- 1000 grams per ton of feed. Administer in feed to chickens 0 to 5 days of age, follow with second administration in feed for 24- 48 hours at 3 to 5 weeks of age.

Oral

As tylosin phosphate. Withdraw 5 days before slaughter.

McNess Custom Premix L200

Broiler and replacement chickens

2 grams per gallon; should be treated for three days; however, treatment may be administered for one to five days depending on the severity of infection. Treated chickens should consume enough medicated drinking water to provide 50 milligrams (mg) tylosin per pound body weight per day.

Oral

Only medicated water should be available to birds. Chickens must not be slaughtered for food within 24 hours after treatment. Do not use in layers producing eggs for human consumption.

BiloVet®

Broiler chickens

851 to 1,419 mg/gallon (225 to 375 ppm) in drinking water for five consecutive days.

Oral

BiloVet®

Honey Bees

Mix 200 milligrams tylosin in 20 grams confectioners/powdered sugar. Use immediately. Apply (dust) this mixture over the top bars of the brood chamber once weekly for 3 weeks.

Oral

The drug should be fed early in the spring or fall and consumed by the bees before the main honey flow begins, to avoid contamination of production honey. Complete treatments at least 4 weeks prior to main honey flow.

BiloVet®

Honey Bees

200 mg/colony in confectioners/powdered sugar.

Oral

Tylan Soluble™

200 mg/colony in confectioners/powdered sugar. Administer three treatments of medicated confectioners sugar once weekly for 3 weeks. The 200 mg dose is applied (dusted) over the top bars of the brood chamber.

Oral

Tylovet® Soluble

2 grams per gallon; should be treated for three days; however, treatment may be administered for 2 to 5 days depending on the severity of infection. Treated turkeys should consume enough medicated drinking water to provide 60 mg tylosin base per pound body weight per day. Only medicated water should be available to birds.

Oral

Only medicated water should be available to birds. Turkeys must not be slaughtered for food within 5 days after treatment. Do not use in layers producing eggs for human consumption.

BiloVet®

2,000 mg/gallon (528 ppm) in drinking water.

Oral

Only medicated water should be available to the birds.

Tylan Soluble™

Please see NADA 139-192 for more information.

Oral

Please see NADA 139-192 for more information.

MGA® and Tylan™

Dosage and Administration Dosages: Chickens: NE indication: 851 to 1,419 mg/gallon (225 to 375 ppm) in drinking water. CRD indications: 2,000 mg/gallon (528 ppm) in drinking water. Turkeys: 2,000 mg/gallon (528 ppm) in drinking water. Swine: 250 mg/gallon (66 ppm) in drinking water. Honey Bees: 200 mg/colony in confectioners/powdered sugar. Mixing Directions for Medicated Drinking Water: Always add the water to the powder. Do not pour the powder into the water. Prepare a fresh Bilovet solution every three days. When mixing and handling tylosin, use protective clothing and impervious gloves. If using a water medicating pump see table below, otherwise mix as follows: To assure thorough dissolution, first place the contents of one jar/packet in a mixing container and add one gallon of water (3785 mL) to the powder to make a concentrated solution. To make medicated drinking water containing 250 mg/gallon (66 ppm), mix this concentrated solution with water to make 400 gallons (1514 liters) of medicated drinking water. To make medicated drinking water containing 851 to 1,419 mg/gallon (225 to 375 ppm), mix this concentrated solution with water to make from 117 gallons + 51 ounces (444 liters) to 70 gallons + 64 ounces (267 liters) of medicated drinking water, respectively. To make medicated drinking water containing 2,000 mg/gallon (528 ppm), mix this concentrated solution with water to make 50 gallons (189 liters) of medicated drinking water. Mixing Directions for use in Honey Bees: Mix 200 mg tylosin in 20 g confectioners/powdered sugar. Use immediately. Directions for Use Chickens: NE indication: Administer medicated drinking water for a single five day period in broiler chickens. To assure all birds receive the intended medication, only medicated water should be available. These practices should be followed to assure both food safety and responsible antimicrobial drug use in chickens: 1) Use in flocks exhibiting signs of a necrotic enteritis outbreak, for example, increased mortality and lesions characteristic of necrotic enteritis upon necropsy; 2) Administer the full dose and dosing regimen once medication initiated; 3) Use of BiloVet or another macrolide is not advised if additional therapy is needed beyond the original course of medication. Chickens: CRD indications: Administer medicated drinking water for three days; however, medicated water may be administered for one to five days depending upon severity of infection. Treated chickens must consume enough medicated water to provide 50 mg per pound of body weight per day. Only medicated water should be available to the birds. Turkeys: Administer medicated drinking water for three days; however, medicated water may be administered for two to five days depending upon severity of infection. Treated turkeys must consume enough medicated water to provide 60 mg per pound of body weight per day. Only medicated water should be available to the birds. Swine: SD indication: Administer medicated drinking water for 3 to 10 days, depending upon severity of infection. Alternatively, administer medicated drinking water for 3 to 10 days, followed by 40 to 100 g of tylosin per ton of complete feed (Type C medicated feed manufactured from tylosin phosphate Type A medicated article) for 2 to 6 weeks. Only medicated water should be available to swine while medicating with BiloVet. PPE indication: Administer medicated drinking water for 3 to 10 days, followed by 40 to 100 g of tylosin per ton of complete feed (Type C medicated feed manufactured from tylosin phosphate Type A medicated article) for 2 to 6 weeks. Only medicated water should be available to swine while medicating with BiloVet. Honey Bee Colonies: Administer three treatments of medicated confectioners sugar once weekly for 3 weeks. The 200 mg dose is applied (dusted) over the top bars of the brood chamber.

ORAL

FDA application 200-455

DOSAGE AND ADMINISTRATION: Dosages: Chickens: NE indication: 851 to 1,419 mg/gallon (225 to 375 ppm) in drinking water. CRD indications: 2,000 mg/gallon (528 ppm) in drinking water. Turkeys: 2,000 mg/gallon (528 ppm) in drinking water. Swine: 250 mg/gallon (66 ppm) in drinking water. Honey Bees: 200 mg/colony in confectioners/powdered sugar. Mixing Directions for Medicated Drinking Water: Always add the water to the powder. Do not pour the powder into the water. Prepare a fresh Tylosin Soluble Powder solution every three days. When mixing and handling tylosin, use protective clothing and impervious gloves. If using a water medicating pump see table below, otherwise mix as follows: To assure thorough dissolution, first place the contents of one jar/packet in a mixing container and add one gallon of water (3785 mL) to the powder to make a concentrated solution. To make medicated drinking water containing 250 mg/gallon (66 ppm), mix this concentrated solution with water to make 400 gallons (1514 liters) of medicated drinking water. To make medicated drinking water containing 851 to 1,419 mg/gallon (225 to 375 ppm), mix this concentrated solution with water to make from 117 gallons + 51 ounces (444 liters) to 70 gallons + 64 ounces (267 liters) of medicated drinking water, respectively. To make medicated drinking water containing 2,000 mg/gallon (528 ppm), mix this concentrated solution with water to make 50 gallons (189 liters) of medicated drinking water. Mixing Directions for Water Medicating Pump (1 :128 inclusion)* Desired Concentration in Drinking Water Jars/Packets of Tylosin Soluble Powder Volume of water to make Stock Solution 250 mg/gallon (66ppm) 1 3 gallons + 13 ounces 851 mg/gallon (225 ppm) 5 4 gallons + 77 ounces 1,419 mg/gallon (375 ppm) 9 5 gallons + 0 ounces 2,000 mg/gallon (528 ppm) 10 3 gallons + 115 ounces *This table applies only if the water medicating pump is set to deliver 1 ounce of stock solution per gallon of drinking water. Mixing Directions for use in Honey Bees: Mix 200 mg tylosin in 20 g confectioners/powdered sugar. Use immediately.

ORAL

FDA application 200-455

Dosage and Administration Dosages: Chickens: NE indication: 851 to 1,419 mg/gallon (225 to 375 ppm) in drinking water. CRD indications: 2,000 mg/gallon (528 ppm) in drinking water. Turkeys: 2,000 mg/gallon (528 ppm) in drinking water. Swine: 250 mg/gallon (66 ppm) in drinking water. Honey Bees: 200 mg/colony in confectioners/powdered sugar. Mixing Directions for Medicated Drinking Water: Always add the water to the powder. Do not pour the powder into the water. Prepare a fresh Tylovet Soluble solution every three days. When mixing and handling tylosin, use protective clothing and impervious gloves. If using a water medicating pump see table below, otherwise mix as follows: To assure thorough dissolution, first place the contents of one pouch in a mixing container and add one gallon of water (3785 mL) to the powder to make a concentrated solution. To make medicated drinking water containing 250 mg/gallon (66 ppm), mix this concentrated solution with water to make 400 gallons (1514 liters) of medicated drinking water. To make medicated drinking water containing 851 to 1,419 mg/gallon (225 to 375 ppm), mix this concentrated solution with water to make from 117 gallons + 51 ounces (444 liters) to 70 gallons + 64 ounces (267 liters) of medicated drinking water, respectively. To make medicated drinking water containing 2,000 mg/gallon (528 ppm), mix this concentrated solution with water to make 50 gallons (189 liters) of medicated drinking water.

ORAL

FDA application 200-473

Administer 1 implant - the entire contents of one cartridge cell (5 pellets) - subcutaneously in the back of the middle third of the ear. Study and carefully follow at all times the "IMPLANTING INSTRUCTIONS" presented below, avoiding short cuts. Skin infection can be avoided by properly preparing implant site and implanter. During fly season use fly repellent on implant site. One designated team member should always do the implanting. Cleanliness of hands and instruments is important at all times. Withdrawal Periods and Residue Warnings No withdrawal period is required when used according to labeling. Do not use in beef calves less than 45 days of age, dairy calves, and veal calves. Do not use in bull calves intended for reproduction. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in dairy cows or in animals intended for subsequent breeding. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Implant pellets subcutaneously in ear only. Any other location is a violation of Federal law. Do not attempt salvage of implanted site for human or animal food.

SUBCUTANEOUS

FDA application 110-315

Ractopamine is fed at a concentration of 9.8 to 24.6 g of ractopamine per ton of complete feed (based on 90% dry matter basis) to provide 90-430 mg ractopamine/head/day in cattle fed in confinement for slaughter during the last 28 to 42 days on feed. Monensin is added to feedlot cattle diets at concentrations of 10 to 40 g monensin USP per ton of complete feed to provide 0.14 to 0.42 mg monensin/lb of body weight/day, depending on severity of coccidiosis challenge, up to a maximum of 480 mg monensin/head/day. Tylosin is added to the cattle diets at concentrations of 8 to 10 g tylosin phosphate per ton complete feed to provide 60 to 90 mg tylosin/head/day. Melengestrol acetate is added to the diet of heifers at 0.5 to 2.0 pounds per head per day of medicated feed containing 0.125 to 1.0 mg melengestrol acetate per pound to provide 0.25 to 0.5 mg melengestrol acetate per head per day in heifers fed in confinement for slaughter. Feed melengestrol acetate in this combination for the final 28 to 42 days.

Oral

Feed continuously as sole ration during the last 28 to 42 days on feed. Melengestrol acetate is not effective in steers and spayed heifers. Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at time of loading. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite. Ractopamine HCl is not for animals intended for breeding. Do not use in calves to be processed for veal. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Special considerations: Mixing directions for liquid melengestrol acetate Type C feeds stored in recirculation tank systems, labeling indicates: “Recirculate immediately prior to use for no less than 10 minutes, moving not less than 1 percent of the tank contents from the bottom of the tank to the top. Recirculate daily, as directed in this paragraph even when the Type C feed is not used.” For liquid melengestrol Type C feeds stored in mechanical, air or other agitation-type tank systems: “Agitate immediately prior to use for not less than 10 minutes, creating turbulence at the bottom of the tank that is visible at the top. Agitate daily, as directed in this paragraph, even when the Type C feed is not used.”

Actogain™ 45/Rumensin®/Tylovet® 100/MGA®

4.5 to 9 g/ton ractopamine hydrochloride and 40 to 100 g/ton tylosin (as tylosin phosphate) per ton of Type C medicated feed. No increased benefit has been shown when ractopamine hydrochloride concentrations in the diet are greater than 4.5 g/ton (5 ppm). Feed as the sole ration to finishing swine weighing at least 150 lbs for the last 45 to 90 lbs (group average) of weight gain prior to slaughter. Feed 40 to 100 grams of tylosin per ton of complete feed for 2 to 6 weeks immediately after medicating with tylosin in drinking water (250 mg tylosin per gallon) for 3 to 10 days. Ractopamine hydrochloride use may increase the number of injured, lame, and/or fatigued pigs during marketing. Behavioral signs such as hyperactivity, anxiety, and aggression have been reported in pigs fed ractopamine hydrochloride. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

Oral

Engain™ and Tylovet®

4.5 to 9 g/ton ractopamine hydrochloride and 40 or 100 g/ton tylosin (as tylosin phosphate) per ton of Type C medicated feed. No increased benefit has been shown when ractopamine hydrochloride concentrations in the diet are greater than 4.5 g/ton (5 ppm). Feed as the sole ration to finishing swine weighing at least 150 lbs for the last 45 to 90 lbs (group average) of weight gain prior to slaughter. Feed 100 g of tylosin per ton of complete feed for at least three weeks, followed by 40 g tylosin per ton of complete feed until pigs reach market weight. Ractopamine hydrochloride use may increase the number of injured, lame, and/or fatigued pigs during marketing. Behavioral signs such as hyperactivity, anxiety, and aggression have been reported in pigs fed ractopamine hydrochloride. Do not use in any finished feed (supplement, concentrate or complete feed) containing in excess of 2% bentonite.

Oral

Engain™ and Tylovet®

ADMINISTRATION AND DOSAGE: BiloVet is administered intramuscularly. Use automatic syringe equipment only BEEF CATTLE AND NON-LACTATING DAIRY CATTLE: Inject intramuscularly 8 mg per pound of body weight one time daily (1 mL per 25 pounds). Treatment should be continued 24 hours following remission of disease signs, not to exceed 5 days. Do not inject more than 10 mL per site. SWINE: Inject intramuscularly 4 mg per pound of body weight (1 mL per 50 pounds) twice daily. Treatment should be continued 24 hours following remission of disease signs, not to exceed 3 days. Do not inject more than 5 mL per site. Read accompanying directions fully before use. CAUTION: Do not mix BiloVet with other injectable solutions as this may cause a precipitation of the active ingredients.

INTRAMUSCULAR

BiloVet® (tylosin injection)For Use In Cattle and Swine OnlyUse automatic syringe equipment only200 mg per mLAn Antibiotic

Zilpaterol hydrochloride is fed at a concentration of 6.8 g of zilpaterol hydrochloride per ton of complete feed to provide 60 to 90 mg zilpaterol/head/day in cattle fed in confinement for slaughter during the last 20 to 40 days on feed. Monensin USP is added to diets for cattle fed in confinement for slaughter at concentrations of 10 to 40 g of monensin USP per ton of complete feed at a rate of 0.14 to 0.42 mg monensin/lb of body weight, depending on severity of coccidiosis challenge, up to 480 mg/head/day. Tylosin phosphate is added to the cattle diets at concentrations of 8 to 10 g of tylosin phosphate per ton of complete feed to provide 60 to 90 mg tylosin/head/day.

Oral

Do not use in calves to be processed for veal. Feed continuously as the sole ration during the last 20 to 40 days on feed. Not to be fed to cattle in excess of 90 mg zilpaterol/head/day in complete feed. If pen consumption of complete feed exceeds 26.5 lb/head/day (90 percent dry matter basis), zilpaterol should not be fed in complete feed. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Special considerations: 1) Labeling of Type B and Type C cattle feeds shall bear the following: (i) Do not allow horses or other equines access to feed containing monensin. Ingestion of monensin by horses has been fatal. Monensin medicated cattle feed is safe for use in cattle only. Consumption by unapproved species may result in toxic reactions. Do not exceed the levels of monensin recommended in the feeding directions, as reduced average daily gains may result. If feed refusals containing monensin are fed to other groups of cattle, the concentration of monensin in the refusals and amount of refusals fed should be taken into consideration to prevent monensin overdosing. (ii) Zilpaterol hydrochloride is not for use in animals intended for breeding. (iii) Do not allow horses or other equines access to feed containing zilpaterol. (iv) Do not use in veal calves. 2) Type B Liquid Feeds can be manufactured containing 68 to 680 g zilpaterol hydrochloride/ton. The liquid Type B feeds must be maintained at a pH of 3.8 to 7.5. For liquid feeds stored in recirculating tank systems: Recirculate immediately prior to use for not less than 10 minutes, moving not less than 1 percent of the tank contents per minute from the bottom of the tank to the top. Recirculate daily as described even when not used. For liquid feeds stored in mechanical, air or other agitation-type tank systems: Agitate immediately prior to use for not less than 10 minutes, creating turbulence at the bottom of the tank that is visible at the top. Agitate daily as described even when not used.

Zilmax®/Rumensin®/Tylovet® 100

Mixing Directions for Water Medicating Pump (1:128 inclusion)*: Desired Concentration in Drinking water Pouches of Tylovet Soluble Volume of Water to Make Stock Solution 250 mg/gallon (66 ppm) 1 3 gallons + 13 ounces 851 mg/gallon (225 ppm) 5 4 gallons + 77 ounces 1,419 mg/gallon (375 ppm) 9 5 gallons + 0 ounces 2,000 mg/gallon (528 ppm) 10 3 gallons + 115 ounces *This table applies only if the water medicating pump is set to deliver 1 ounce of stock solution per gallon of drinking water. Mixing Directions for use in Honey Bees: Mix 200 mg tylosin in 20 g confectioners/powdered sugar. Use immediately.

ORAL

FDA application 200-473

Tylosin phosphate is added to chicken feed at concentrations of 4 to 50 g/ton for increased rate of weight gain and improved feed efficiency in broiler chickens. Salinomycin sodium is added to chicken feed at concentrations of 40 to 60 g/ton for the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati in broiler chickens

Oral

Feed continuously as sole ration. For broiler chickens only. Do not feed to laying hens. Not approved for use with pellet binders. May be fatal if accidentally fed to adult turkeys or horses

Tylovet® 100 plus Sacox®

: Tylosin phosphate is added to chicken feed at concentrations of 4 to 50 g/ton. Salinomycin sodium is added to chicken feed at concentrations of 40 to 60 g/ton. <span style="font-size: 10pt; font-family: 'Verdana','sans-serif'; line-height: 115%; mso-fareast-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: EN-US;

Oral

For broiler chickens only. Feed continuously as sole ration. Do not feed to laying hens. Not approved for use with pellet binders. May be fatal if accidentally fed to adult turkeys or horses.

Tylovet®100 plus Bio-cox®

: Tylosin phosphate is added to chicken feed at concentrations of 4 to 50 g/ton Salinomycin sodium is added to chicken feed at concentrations of 40 to 60 g/ton <span style="font-size: 10pt; font-family: 'Verdana','sans-serif'; mso-fareast-font-family: Calibri;

Oral

For broiler chickens only. Feed continuously as sole ration. Do not feed to laying hens. Not approved for use with pellet binders. May be fatal if accidentally fed to adult turkeys or horses.

Tylan® plus Sacox®

Tylan 200 Inyectable se administra por vía intramuscular.

INTRAMUSCULAR

FDA application 012-965

Tylan 200 Injection is administered intramuscularly.

INTRAMUSCULAR

FDA application 012-965

Dosages:

ORAL

FDA application 013-076