Oxytetracycline

Cattle (calves, beef, and nonlactating dairy)

For treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline.

Feed continuously for 7 to 14 days. Zero-day withdrawal time.

Terramycin® 10

Cattle (calves, beef, and nonlactating dairy)

For growing cattle (over 400 lb) for the reduction of the incidence of liver abscesses.

Feed continuously.

Terramycin® 10

Cattle (calves, beef, and nonlactating dairy)

For prevention and treatment of the early stages of shipping fever complex.

Feed 3 to 5 days before and after arrival in feedlots.

Terramycin® 10

Cattle (beef, nonlactating dairy, and beef and dairy calves [excluding veal])

Treatment of bacterial pneumonia and shipping fever complex associated with Pasteurella spp.; bacterial enteritis (scours) caused by Escherichia coli; necrotic pododermatitis (foot rot) and calf diphtheria caused by Fusobacterium necrophorum; wooden tongue caused by Actinobacillus lignieresi; and wound infections, acute metritis, and traumatic injury caused by oxytetracycline-susceptible staphylococcal and streptococcal organisms.

Medamycin® 100

Cattle (beef, non-lactating dairy, and beef and dairy calves [excluding veal])

Treatment of bacterial pneumonia and shipping fever complex associated with Pasteurella spp.; bacterial enteritis (scours) caused by Escherichia coli; necrotic pododermatitis (foot rot) and calf diphtheria caused by Fusobacterium necrophorum; wooden tongue caused by Actinobacillus lignieresi; and wound infections, acute metritis, and traumatic injury caused by oxytetracycline susceptible staphylococcal and streptococcal organisms.

MAXIM 100

Cattle (beef and nonlactating dairy)

Treatment of diseases due to oxytetracycline-susceptible organisms as follows: Pneumonia and shipping fever complex associated with Pasteurella species and Hemophilus species, foot-rot and diphtheria caused by Fusobacterium necrophorum, bacterial enteritis (scours) caused by Escherichia coli, wooden tongue caused by Actinobacillus lignieresii, leptospirosis caused by Leptospira pomona, and wound infections and acute metritis caused by Staphylococcus species and Streptococcus species. If labeled for use by or on the order of a licensed veterinarian, it may be used for the treatment of anaplasmosis caused by Anaplasma marginale and anthrax caused by Bacillus anthracis.

Treatment of all diseases should be instituted early and continue for 24 to 48 hours beyond remission of disease symptoms but not to exceed a total of 4 consecutive days. Consult your veterinarian if no improvement is noted within 48 hours. Do not inject more than 10 milliliters per site in adult cattle, reducing the volume according to age and body size to 1 to 2 milliliters in small calves. Exceeding the highest recommended dose of 5 milligrams per pound of body weight, administering at recommended levels for more than 4 consecutive days, and/or exceeding 10 milliliters intramuscularly per injection site may result in antibiotic residues beyond the withdrawal time. Discontinue treatment at least 15 days prior to slaughter. Not for use in lactating dairy cattle.

Rachelle Oxyvet Injection

Cattle (beef and nonlactating dairy)

Treatment of diseases due to oxytetracycline-susceptible organisms as follows: Pneumonia and shipping fever complex associated with Pasteurella species, Hemophilus species, and Klebsiella species, foot-rot and diphtheria caused by Spherophorus necrophorus, bacterial enteritis (scours) caused by Escherichia coli, wooden tongue caused by Actinobacillus lignieresi, leptospirosis caused by Leptospira pomona, and wound infections and acute metritis caused by Staphylococcus species and Streptococcus species. If labeled for use by or on the order of a licensed veterinarian, it may be used for the treatment of anaplasmosis caused by Anaplasma marginale.

Treatment of all diseases should be instituted early and continue for 24 to 48 hours beyond remission of disease symptoms, but not to exceed a total of 4 consecutive days. Consult your veterinarian if no improvement is noted within 48 hours. Do not inject more than 10 milliliters per site in adult cattle, reducing the volume according to age and body size to 0.5 to 2 milliliters in small calves. Exceeding the highest recommended dose of 5 milligrams per pound of body weight, administering at recommended levels for more than 4 consecutive days, and/or exceeding 10 milliliters intramuscularly per injection site may result in antibiotic residues beyond the withdrawal time. Discontinue treatment at least 18 days prior to slaughter. Not for use in lactating dairy cattle. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and /or in calves born to these cows.

Bio-Mycin C

Cattle (beef and nonlactating dairy)

The drug is intended for use in the treatment of disease due to oxytetracycline-susceptible organisms in beef cattle and non-lactating dairy cattle. It is indicated in the treatment of pneumonia and shipping fever complex associated with Pasteurella species, Hemophilus species, Klebsiella species, foot-rot and diphtheria caused by Spherophorus necrophorus, bacterial enteritis (scours) caused by Escherichia coli, wooden tongue caused by Actinobacillus lignieresi, acute metritis, and wound infections caused by staphylococcal and streptococcal organisms.

Not for use in lactating dairy cattle. Discontinue treatment at least 19 days prior to slaughter. When administered intramuscularly within 30 days of slaughter, muscle discoloration may necessitate trimming of the injection site and surrounding tissues.

Aquachel-100

Cattle (beef and nonlactating dairy)

For the treatment of pneumonia and shipping fever complex associated with Pasteurella spp. and Hemophilus spp.; infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis; foot rot and diphtheria caused by Fusobacterium necrophorum; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresii; leptospirosis caused by Leptospira pomona; and wound infections and acute metritis caused by strains of staphylococci and streptococci organisms sensitive to oxytetracycline.

Oxytetracycline Injection

Cattle (beef and nonlactating dairy)

Treatment of pneumonia and shipping fever complex associated with Pasteurella sp., Hemophilus sp., and Klebsiella sp., foot rot and diphtheria caused by Spherophorus necrophorus, bacterial enteritis (scours) caused by Escherichia coli, wooden tongue caused by Actinobacillus lignieresi, leptospirosis caused by Leptospira pomona, acute metritis, anaplasmosis caused by Anaplasma marginale, and wound infections caused by Staphylococcal and Streptococcal organisms.

Bio-Mycin®

Cattle (beef and nonlactating dairy)

It is used for the treatment of pneumonia and shipping fever complex associated with Pasteurella species and Hemophilus species; foot-rot and diphtheria caused by Spherophorus necrophorus; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresi; leptospirosis caused by Leptospira pomona; wound infections and acute metritis caused by staphylococcal and streptococcal organisms.

Treatment of all diseases should be instituted early. Treatment should continue for 24 to 48 hours beyond the remission of disease symptoms, but not exceed a total of 4 consecutive days. If no improvement is noted within 24 to 48 hours, diagnosis and therapy should be reevaluated. When injecting intramuscularly in adult livestock, do not inject more than 10 milliliters at any one site. The volume administered per injection site should be reduced according to age and body size so that 1 or 2 milliliters are injected in smaller animals such as small calves. Intravenous administration is recommended in cattle when daily dosage exceeds 50 milliliters. Treatment must be discontinued at least 22 days prior to slaughter for cattle. When administered intramuscularly to animals within 30 days of slaughter, muscle discoloration may necessitate trimming of the injection site(s) and surrounding tissues during the dressing procedure. Not for use in lactating dairy animals.

Liquamycin® Injectable

Cattle (beef and nonlactating dairy)

For the treatment of the following conditions : 1) bacterial pneumonia caused by Pasteurella spp. (shipping fever) in yearlings, where re-treatment is impractical due to husbandry conditions, such as cattle on range, or where repeated restraint is inadvisable; 2) infectious bovine keratoconjunctivitis (pinkeye) cause by Moraxella bovis.

Oxytetracycline Injection

Cattle (calves, beef and nonlactating dairy)

Control and treatment of bacterial enteritis caused by E. coli and bacterial pneumonia (shipping fever complex) caused by P. multocida susceptible to oxytetracycline.

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Prepare a fresh solution daily. Administer up to 14 days. Do not use for more than 14 consecutive days. Use as sole source of oxytetracycline. Do not administer this product with milk or milk replacers. Administer 1 hour before or 2 hours after feeding milk or milk replacers. Withdraw 5 days prior to slaughter. A milk discard period has not been established for this product in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older.

Tetroxy® 25

Cattle (beef cattle; dairy cattle; calves, including preruminating (veal) calves)

For the treatment of pneumonia and shipping fever complex associated with Pasteurella spp. and Hemophilus spp; infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis; foot-rot and diphtheria caused by Fusobacterium necrophorum; bacterial bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresii; leptospirosis caused by Leptospira pomona; and wound infections and acute metritis caused by strains of staphylococci and streptococci organisms sensitive to oxytetracycline.

MAXIM-200

Cattle (beef cattle; dairy cattle; calves, including preruminating (veal) calves)

For the treatment of the following conditions: 1) bacterial pneumonia caused by Pasteurella spp. (shipping fever) in calves and yearlings, where retreatment is impractical due to husbandry conditions, such as cattle on range, or where repeated restraint is inadvisable; 2) infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis.

MAXIM-200

Beef cattle, dairy cattle, and calves including prerumenative (veal) calves

For the treatment of pneumonia and shipping fever complex associated with Pasteurella spp. and Hemophilus spp.; infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis; foot rot and diphtheria caused by Fusobacterium necrophorum; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresii; leptospirosis caused by Leptospira pomona; anaplasmosis caused by Anaplasma marginale; anthrax caused by Bacillus anthracis; and wound infections and acute metritis caused by strains of staphylococci and streptococci organisms sensitive to oxytetracycline.

Liquamycin® LA-200®

Beef cattle, dairy cattle, and calves including prerumenative (veal) calves

Treatment of infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis; and in the treatment of the following conditions where retreatment is impractical due to husbandry conditions, such as cattle on range, or where their repeated restraint is inadvisable: bacterial pneumonia caused by Pasteurella spp. (shipping fever) in calves and yearlings, and anaplasmosis caused by Anaplasma marginale.

Liquamycin® LA-200®

Beef cattle, dairy cattle, and calves including prerumenative (veal) calves

For the treatment of the following conditions: 1) bacterial pneumonia caused by Pasteurella spp. (shipping fever) in calves and yearlings, where retreatment is impractical due to husbandry conditions, such as cattle on range, or where repeated restraint is inadvisable; 2) infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis.

AGRIMYCIN® 200

Cattle (beef and dairy)

For the treatment of pneumonia and shipping fever complex associated with Pasteurella spp. and Haemophilus spp.; infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis; foot-rot and diphtheria caused by Fusobacterium necrophorum; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresii; leptospirosis caused by Leptospira pomona; and wound infections and acute metritis caused by strains of staphylococci and streptococci organisms sensitive to oxytetracycline.

Bio-Mycin® 200

Cattle (beef and dairy)

For the treatment of the following conditions : 1) bacterial pneumonia caused by Pasteurella spp. (shipping fever) in yearlings, where re-treatment is impractical due to husbandry conditions, such as cattle on range, or where repeated restraint is inadvisable; 2) infectious bovine keratoconjunctivitis (pinkeye) cause by Moraxella bovis.

Bio-Mycin® 200

Beef Cattle, Non-lactating Dairy Cattle, and Calves including Pre-ruminating (Veal) Calves

For treatment of pneumonia and shipping fever complex associated with Pasteurella species and Histophilus species, foot-rot and diphtheria caused by Fusobacterium necrophorum, bacterial enteritis (scours) caused by Escherichia coli, wooden tongue caused by Actinobacillus lignieresii, leptospirosis caused by Leptospira pomona, and wound infections and acute metritis caused by strains of staphylococcal and streptococcal organisms sensitive to oxytetracycline.

Noromycin® 300 LA

Beef Cattle, Non-lactating Dairy Cattle, and Calves including Pre-ruminating (Veal) Calves

For treatment of bacterial pneumonia caused by Pasteurella species (shipping fever) in calves and yearlings where treatment is impractical due to husbandry conditions, such as cattle on range, or where their repeated restraint is inadvisable; or for treatment of infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis.

Noromycin® 300 LA

Beef Cattle, Non-lactating Dairy Cattle, and Calves including Pre-ruminating (Veal) Calves

For control of respiratory disease in cattle at high risk of developing bovine respiratory disease associated with Mannheimia (Pasteurella) haemolytica.

Noromycin® 300 LA

Cattle (calves, beef, and non lactating dairy)

Control and treatment of bacterial enteritis caused by E. coli and bacterial pneumonia (shipping fever complex) caused by P. multocida susceptible to oxytetracycline.

Prepare a fresh solution daily. Administer up to 14 days. Do not use for more than 14 consecutive days. Use as sole source of oxytetracycline. Do not administer this product with milk or milk replacers. Administer 1 hour before or 2 hours after feeding milk or milk replacers. Withdraw 5 days prior to slaughter. A milk discard period has not been established for this product in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older.

TERRAMYCIN-343®

Terramycin® is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A.aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions whichmay occur secondary to other infectious diseases in the above species.

Terramycin®

For the prevention and treatment of the early stages of shipping fever complex.

Feed 3-5 days before and after arrival in feedlots. A withdrawal period has not been established for use in pre-ruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older.

Neo-Oxy 100/100 MR®

Cattle (beef and non-lactating dairy: growing cattle over 400 pounds)

For the reduction of the incidence of liver abscesses.

Feed continuously.

TM-50®

Cattle (calves including veal calves, beef, and non-lactating dairy)

Treatment of bacterial enteritis caused by E. coli and bacterial pneumonia (shipping fever complex) caused by P. multocida susceptible to oxytetracycline).

Feed continuously for 7 to 14 days. Withdraw 0 days before slaughter.

TM-50®

Cattle (calves including veal calves, beef, and non-lactating dairy)

For prevention and treatment of the early stages of shipping fever complex.

Feed 3 to 5 days before and after arrival in feedlots.

TM-50®

Cattle (calves including veal calves, beef, and non-lactating dairy)

Treatment of bacterial enteritis caused by E. coli.

Feed continuously for 7 to 14 days. In milk replacer or starter feed. Withdraw 0 days before slaughter. When used in milk replacers, the treatment claim (10 mg/lb) is limited to bacterial enteritis caused by E. coli only.

TM-50®

Cattle (beef and dairy calves)

For treatment of bacterial enteritis caused by Salmonella typhimurium and Escherichia coli (colibacillosis) and bacterial pneumonia (shipping fever complex, pasteurellosis) caused by Pasteurella multocida.

Terramycin® Scours Tablets

Cattle (beef and non-lactating dairy, beef and dairy calves)

Treatment of pneumonia and shipping fever complex associated with Pasteurella sp., Hemophilus sp., and Klebsiella sp., bacterial enteritis (scours) caused by Escherichia coli, foot rot and diphtheria caused by Spherophorus necrophorus, wooden tongue caused by Actinobacillus lignieresi, leptospirosis caused by Leptospira pomona, and wound infections, acute metritis, and traumatic injury caused by a variety of bacterial organisms (such as streptococcal and staphylococcal organisms.

Oxyject®

Cattle (heifers fed in confinement for slaughter)

For increased rate of weight gain, improved feed efficiency, suppression of estrus (heat) and for the reduction of incidence of liver abscesses in heifers being fed in confinement for slaughter.

Not effective in steers and spayed heifers. Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at the time of loading. Do not mix with oxytetracycline as a common liquid feed supplement. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

MGA® (liquid) and TM®

Cattle (heifers fed in confinement for slaughter)

For increased rate of weight gain, improved feed efficiency, and suppression of estrus (heat, and reduction of liver condemnation due to liver abscesses.

Add at the rate of 0.5 to 2.0 pounds per head per day a medicated feed (liquid or dry) containing 0.125 to 1.0 milligram of melengestrol acetate per pound to a feed containing 6 to 10 grams of oxytetracycline per ton; or add at the rate of 0.5 to 2.0 pounds per head per day a dry medicated feed containing 0.125 to 1.0 milligram of melengestrol acetate plus 37.5 to 150 milligrams of oxytetracycline per pound to provide 0.25 to 0.5 milligram of melengestrol acetate and 75 milligrams of oxytetracycline per head per day. Liquid melengestrol acetate may not be mixed with oxytetracycline in a common liquid feed supplement.

MGA® (liquid) and TM®

Cattle (heifers in confinement fed for slaughter)

For increased rate of weight gain, improved feed efficiency, suppression of estrus (heat) and for the reduction of incidence of liver abscesses in heifers being fed in confinement for slaughter.

Not effective in steers and spayed heifers. Withdrawal periods of three to five days should be avoided to prevent thepossibility that the heifers may come into estrus (heat) at the time of loading.Do not mix with oxytetracycline as a common liquid feed supplement. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

MGA® and TM®

Cattle (beef, beef calves, nonlactating dairy, dairy calves)

The drug is used for treatment of bacterial pneumonia and shipping fever complex associated with Pasteurella species; foot-rot and diphtheria caused by Spherophorus necrophorus; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresi; wound infections and acute metritis caused by staphylococcal and streptococcal organisms susceptible to oxytetracycline.

If no improvement is noted within 24 to 48 hours, consult a veterinarian for diagnosis and therapy. In adult livestock, do not inject more than 10 milliliters at any one site. Rapid intravenous administration may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least5 minutes.

Oxytetracycline-50

Cattle (calves)

For treatment of bacterial enteritis caused by Escherichia coli organisms susceptible to oxytetracycline.

Pennox 100-MR®

Calves, Beef Cattle, and Non-Lactating Dairy Cattle

For treatment of bacterial enteritis caused by E. coli and bacterial pneumonia (shipping fever complex) caused by P. multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin.

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100D

Calves, Beef Cattle, and Non-Lactating Dairy Cattle

Treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline

Feed continuously for 7-14 days

Terramycin® 200

Calves, Beef Cattle, and Non-Lactating Dairy Cattle

For growing cattle (over 400 lb) for the reduction of the incidence of liver abscesses.

Feed continuously.

Terramycin® 200

Calves, Beef Cattle, and Non-Lactating Dairy Cattle

Prevention and treatment of the early stages of shipping fever complex.

Feed 3-5 days before and after arrival in feedlots.

Terramycin® 200

Cattle (beef,dairy excluding lactating animals, and calves, including preruminating veal calves)

For treatment of pneumonia and shipping fever complex associated with Pasteurella species and Haemophilus species, foot-rot and diphtheria caused by Fusobacterium necrophorum, bacterial enteritis (scours) caused by Escherichia coli, wooden tongue caused by Actinobacillus lignieresii, leptospirosis caused by Leptospira pomona, wound infections and acute metritis caused by Staphylococcus species and Streptococcus species, and anthrax caused by Bacillus anthracis.

Administer intramuscularly, subcutaneously, or intravenously. Exceeding the highest recommended level of drug per pound of bodyweight per day, administering more than the recommended number of treatments, and/or exceeding 10 mL intramuscularly or subcutaneously per injection site may result in antibiotic residues beyond the withdrawal time. Rapid intravenous administration in cattle may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes. Discontinue treatment at least 28 days prior to slaughter. Not for use in lactating dairy animals. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Geomycin 200

Cattle (beef,dairy excluding lactating animals, and calves, including preruminating veal calves)

Where retreatment of calves and yearlings for bacterial pneumonia is impractical, for treatment of infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis, or where retreatment for anaplasmosis is impractical.

Administer intramuscularly or intravenously. Exceeding the highest recommended level of drug per pound of bodyweight per day, administering more than the recommended number of treatments, and/or exceeding 10 mL intramuscularly or subcutaneously per injection site may result in antibiotic residues beyond the withdrawal time. Rapid intravenous administration in cattle may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes. Discontinue treatment at least 28 days prior to slaughter. Not for use in lactating dairy animals. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Geomycin 200

Cattle (beef,dairy excluding lactating animals, and calves, including preruminating veal calves)

For treatment of anaplasmosis, severe foot-rot and advanced cases of other indicated diseases.

Administer intramuscularly, subcutaneously, or intravenously. Exceeding the highest recommended level of drug per pound of bodyweight per day, administering more than the recommended number of treatments, and/or exceeding 10 mL intramuscularly or subcutaneously per injection site may result in antibiotic residues beyond the withdrawal time. Rapid intravenous administration in cattle may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes. Discontinue treatment at least 28 days prior to slaughter. Not for use in lactating dairy animals.

Geomycin 200

Beef cattle; dairy cattle; and calves, including preruminating (veal) calves

For the treatment of pneumonia and shipping fever complex associated with Pasteurella spp. and Haemophilus spp; infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis; foot rot and diphtheria caused by Fusobacterium necrophorum; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresii; leptospirosis caused by Leptospira pomona; and wound infections and acute metritis caused by strains of staphylococci and streptococci organisms sensitive to oxytetracycline.

Oxytetracycline Injection 200

Beef cattle; dairy cattle; and calves, including preruminating (veal) calves

For the treatment of the following conditions: 1) bacterial pneumonia caused by Pasteurella spp. (shipping fever) in calves and yearlings, where retreatment is impractical due to husbandry conditions, such as cattle on range, or where repeated restraint is inadvisable; 2) infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis.

Oxytetracycline Injection 200

Beef and Dairy Calves

For treatment of bacterial enteritis caused by Salmonella typhimurium and Escherichia coli (colibacillosis) and bacterial pneumonia (shipping fever complex, pasteurellosis) caused by Pasteurella multocida.

Dosage should continue until the animal returns to normal and for 24 hours to 48 hours after symptoms have subsided. Treatment should not exceed 4 consecutive days. Do not exceed 500 milligrams per 100 pounds of body weight every 12 hours (10 milligrams per pound daily). Discontinue treatment 7 days prior to slaughter. Not for use in lactating dairy cattle. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

OXY 1000 Calf Bolus

Cattle (beef and nonlactating dairy, beef and dairy calves [excluding veal calves])

Treatment of pneumonia and shipping fever complex associated with Pasteurella spp., Haemophilus spp., and Klebsiella spp.

OXYJECT® 100

Calves (Up to 250 Lbs)

For treatment of bacterial enteritis caused by E. coli susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin.

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

Growing Cattle (Over 400 Lbs)

For reduction of liver condemnation due to liver abscesses.

Feed continuously. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100

Calves, Beef Cattle, and Non-Lactating Dairy

Calves and beef and non-lactating dairy cattle: For treatment of bacterial enteritis caused by E. coli and bacterial pneumonia (shipping fever complex) caused by P. multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin.

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100

Calves (up to 250 Lbs)

For treatment of bacterial enteritis caused by E. coli susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin.

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100D

Growing cattle (over 400 lb)

For reduction of liver condemnation due to liver abscesses.

Feed continuously. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

Calves, Beef Cattle, and Non-lactating Dairy Cattle

Treatment of bacterial enteritis caused by E. coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

Cattle (Beef and Non-Lactating Dairy)

Treatment of diseases due to oxytetracycline-susceptible organisms as follows: pneumonia and shipping fever complex associated with Pasteurella species and Hemophilus species; foot rot and diphtheria caused by Fusobacterium necrophorum; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresii; leptospirosis caused by Leptospira Pomona; acute metritis and wound infections caused by staphylococcal and streptococcal organisms; if labeled for use by or on the order of a licensed veterinarian, it may be used for treatment of anaplasmosis caused by Anaplasma marginale and anthrax caused by Bacillus anthracis.

Treatment should be continued 24 to 48 hours following remission of disease symptoms, but not to exceed a total of 4 consecutive days. If no improvement occurs within 24 to 48 hours, reevaluate diagnosis and therapy. Discontinue use at least 19 days prior to slaughter. This drug product is not approved for use in female dairy cattle 20months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows.

Biocyl-50

Cattle (Beef, Non-Lactating Dairy, Calves, Yearlings)

For the treatment of bacterial pneumonia associated with Pasteurella spp. and for the control of associated pyrexia in beef and non-lactating dairy cattle

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intramuscular or subcutaneous use in beef and non-lactating dairy cattle, calves and yearlings. Not for use in female dairy cattle 20 months of age or older, including dry dairy cows, bulls intended for breeding, and calves intended to be processed for veal. Do not use in animals showing hypersensitivity to either flunixin meglumine or oxytetracycline.

Hexasol® Injection

Cattle (calves up to 250 lbs)

For treatment of bacterial enteritis caused by Escherichia coli susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by Escherichia coli susceptible to neomycin.

Feed continuously for 7 to 14 days; in milk replacers or starter feed. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in pre-ruminating calves. Do not use in calves to be processed for veal.

Neo-Oxy 100/100 MR®

Growing cattle (over 400 lbs)

For the reduction of the incidence of liver abscesses.

Feed continuously.

Neo-Oxy 100/100 MR®

Cattle (calves and beef and nonlactating dairy cattle)

For treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by Escherichia coli susceptible to neomycin.

Feed continuously for 7-14 days in feed or milk replacers. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in pre-ruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter.

Neo-Oxy 100/100 MR®

Cattle (calves, beef, nonlactating dairy)

For treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline.

Pennox 50®

Cattle (growing, over 400 pounds body weight)

For reduction of the incidence of liver abscesses.

Pennox 50®

Cattle (beef, dairy, and calves including preruminating (veal) calves)

For the treatment of pneumonia and shipping fever complex associated with Pasteurella spp. and Haemophilus spp.; infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis; foot rot and diphtheria caused by Fusobacterium necrophorum; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresii; leptospirosis caused by Leptospira pomona; and wound infections and acute metritis caused by strains of staphylococci and streptococci organisms sensitive to oxytetracycline.

Tetroxy®-LA

Cattle (beef, dairy, and calves including preruminating (veal) calves)

For the treatment of the following conditions : 1) bacterial pneumonia caused by Pasteurella spp. (shipping fever) in calves and yearlings, where retreatment is impractical due to husbandry conditions, such as cattle on range, or where repeated restraint is inadvisable; 2) infectious bovine keratoconjunctivitis (pinkeye) cause by Moraxella bovis.

Tetroxy®-LA

Treatment of bacterial enteritis caused by E. coli and Salmonella choleraesuis susceptible to oxytetracycline and treatment of bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin.

Feed continuously for 7-14 days. 5-day withdrawal before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100

For treatment of bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis and treatment of bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by Escherichia coli susceptible to neomycin.

Feed continuously for 7 to 14 days; withdraw 5 days before slaughter.

Neo-Oxy 100/100 MR®

For treatment of bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis susceptible to oxytetracycline and treatment of bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline and increased rate of weight gain and improved feed efficiency.

Feed continuously as the sole ration for 7 to 14 days. Not for use in pregnant swine or swine intended for breeding purposes. Do not mix in feeds containing bentonite. Do not feed to swine within 42 days of slaughter.

Mecadox® and Terramycin®

Where re-treatment for pneumonia is impractical. For the treatment of bacterial pneumonia caused by Pasteurella multocida, where re-treatment is impractical due to husbandry conditions or where repeated restraint is inadvisable.

MAXIM-200

For treatment of bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis susceptible to oxytetracycline and treatment of bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline.

Feed continuously for 7 to 14 days.

Terramycin® 10

For treatment of bacterial enteritis caused by E. coli and Salmonella choleraesuis susceptible to oxytetracycline and treatment of bacterial pneumonia caused by P. multocida susceptible to oxytetracycline.

Feed continuously for 7 to 14 days.

TM-50®

For the control and treatment of bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis and bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline.

Prepare a fresh solution daily. Use as the sole source of oxytetracycline. Administer up to 5 days; do not use for more than 5 consecutive days. Use as sole source of drinking water. Do not mix this product directly with milk or milk replacers. Administer one hour before or two hours after feeding milk or milk replacers. Withdraw zero days prior to slaughter. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

AGRIMYCIN®-343

It is used for the treatment of bacterial enteritis (scours, colibacillosis) caused by Escherichia coli; pneumonia caused by Pasteurella multocida; and leptospirosis caused by Leptospira pomona.

Treatment of all diseases should be instituted early. Treatment should continue for 24 to 48 hours beyond the remission of disease symptoms, but not exceed a total of 4 consecutive days. If no improvement is noted within 24 to 48 hours, diagnosis and therapy should be reevaluated. When injecting intramuscularly in adult livestock, do not inject more than 10 milliliters at any one site. The volume administered per injection site should be reduced according to age and body size so that 1 or 2 milliliters are injected in smaller animals such as young pigs. Treatment must be discontinued at least 22 days prior to slaughter for swine. When administered intramuscularly to animals within 30 days of slaughter, muscle discoloration may necessitate trimming of the injection site(s) and surrounding tissues during the dressing procedure.

Liquamycin® Injectable

For the treatment of bacterial pneumonia caused by Pasteurella multocida, where re-treatment is impractical due to husbandry conditions or where repeated restraint is inadvisable.

Oxytetracycline Injection

For treatment of pneumonia caused by Pasteurella multocida where retreatment for pneumonia is impractical.

Noromycin® 300 LA

Where re-treatment for pneumonia is impractical.

Administer intramuscularly. Do not inject more than 5 mL per site in adult swine. Discontinue treatment at least 28 days prior to slaughter.

Geomycin 200

Swine (breeding stock)

For the control and treatment of leptospirosis (reducing the incidence of abortions and shedding of leptospira) caused by Leptospira pomona susceptible to oxytetracycline.

Prepare a fresh solution daily. Use as the sole source of oxytetracycline. Administer up to 5 days; do not use for more than 5 consecutive days. Use as sole source of drinking water. Do not mix this product directly with milk or milk replacers. Administer one hour before or two hours after feeding milk or milk replacers. Withdraw zero days prior to slaughter. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

AGRIMYCIN®-343

Sows

As an aid in the control of infectious enteritis (baby pig scours, colibacillosis) in suckling pigs caused by Escherichia coli.

MAXIM-200

Swine (sows)

As an aid in the control of infectious enteritis (baby pig scours, colibacillosis) in suckling pigs caused by Escherichia coli.

AGRIMYCIN® 200

Swine (Sows)

As an aid in control of infectious enteritis (baby pig scours, colibacillosis) in suckling pigs caused by Escherichia coli.

Noromycin® 300 LA

Swine (Sows)

As an aid in control of porcine colibacillosis (baby pig scours) in suckling pigs caused by Escherichia coli.

OXYJECT® 100

Breeding Swine

For breeding swine for control and treatment of Leptospirosis (reducing the incidence of abortion and shedding of leptospirae) caused by Leptospira pomona susceptible to oxytetracycline

Feed continuously for not more than 14 days

Terramycin® 200

Swine (sows about to farrow or just farrowed).

Administered to sows as an aid in the control of infectious enteritis (baby pig scours, colibacillosis) in suckling pigs caused by Escherichia coli.

Treatment of all diseases should be instituted early. Treatment should continue for 24 to 48 hours beyond the remission of disease symptoms, but not exceed a total of 4 consecutive days. If no improvement is noted within 24 to 48 hours, diagnosis and therapy should be reevaluated. When injecting intramuscularly in adult livestock, do not inject more than 10 milliliters at any one site. The volume administered per injection site should be reduced according to age and body size so that 1 or 2 milliliters are injected in smaller animals such as young pigs. Treatment must be discontinued at least 22 days prior to slaughter for swine. When administered intramuscularly to animals within 30 days of slaughter, muscle discoloration may necessitate trimming of the injection site(s) and surrounding tissues during the dressing procedure.

Liquamycin® Injectable

Swine (Breeding)

For control and treatment of leptospirosis (reducing the incidence of abortion and shedding of leptospirae) caused by Leptospira pomona susceptible to oxytetracycline.

Feed continuously for not more than 14 days.

TM-50®

Swine (breeding)

For control and treatment of leptospirosis (reducing the incidence of abortion and shedding of leptospirae) caused by Leptospira pomona susceptible to oxytetracycline.

Feed continuously for not more than 14 days.

TM-100®

Swine (sows with litters or about to farrow)

As an aid in control of infections enteritis (baby pig scours, colibacillosis) in suckling pigs caused by Escherichia coli.

Do not inject more than 5 milliliters per site in adult swine, reducing the volume according to age and body size to 1 to 2 milliliters in young pigs. Discontinue treatment at least 22 days prior to slaughter.

Liquamycin® 100

Breeding swine

For control and treatment of leptospirosis (reducing the incidence of abortion and shedding of leptospirae) caused by Leptospira Pomona susceptible to oxytetracycline.

Feed continuously for not more than 14 days; withdraw 5 days before slaughter.

Neo-Oxy 50/50®

For the control of chronic respiratory disease (CRD) and air sac infections caused by Mycoplasma gallisepticum and E. coli susceptible to oxytetracycline; for the control of fowl cholera caused by Pasteurella multocida susceptible to oxytetracycline.

Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption. Use as the sole source of oxytetracycline. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

AGRIMYCIN®-343

As an aid in the prevention and treatment of complicated chronic respiratory disease (air-sac infection) caused by Mycoplasma gallisepticum and secondary bacterial organisms associated with chronic respiratory disease such as E. coli.

Administer for not more than 5 days. Not for use in chickens producing eggs for human consumption. Withdraw 24 hours before slaughter.

MAGNA-TERRAMYCIN® Soluble Powder

Control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and E. coli susceptible to oxytetracycline; control of fowl cholera caused by Pasteurella multocida susceptible to oxytetracycline.

Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption.

TERRAMYCIN-343®

Control of chronic respiratory disease (CRD) and air sac infections caused by Mycoplasma gallisepticum and E. coli and fowl cholera caused by Pasteurella multocida.

Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption.

OXY WS™

For control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and Escherichia coli susceptible to oxytetracycline.

Feed continuously for 7 to 14 days. At 500 g/ton level, withdraw 24 hours before slaughter. Zero-day withdrawal period for lower use levels. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Do not administer to chickens producing eggs for human consumption.

Terramycin® 10

For control of infectious synovitis caused by Mycoplasma synoviae; control of fowl cholera caused by Pasteurella multocida susceptible to oxytetracycline.

Feed continuously for 7 to 14 days. At 500 g/ton level,withdraw 24 hours before slaughter. Zero-day withdrawal period for lower use levels. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Do not administer to chickens producing eggs for human consumption.

Terramycin® 10

For reduction of mortality due to air sacculitis (air-sac-infection) caused by Escherichia coli susceptible to oxytetracycline.

Feed continuously for 5 days. At 500 g/ton level, withdraw 24 hours before slaughter. Zero-day withdrawal period for lower use levels. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Do not administer to chickens producing eggs for human consumption.

Terramycin® 10

For the control of infectious synovitis caused by Mycoplasma synoviae susceptible to oxytetracycline.

Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption. Use as the sole source of oxytetracycline. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

AGRIMYCIN®-343

Chickens (broilers)

For chickens for control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and Escherichia coli susceptible to oxytetracycline, and as an aid in the prevention of coccidiosis caused by Eimeria necatrix, Eimeria tenella, Eimeria acervulina, Eirmeria brunetti, Eimeria mivati, and Eimeria maxima.

Feed continuously for 7 to 14 days. Do not feed to chickens producing eggs for human consumption. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Withdraw 5 days before slaughter. Feed must be used within 50 days from date of manufacture. Do not use in feeds containing bentonite.

TM® plus Robenz®

Chickens (broilers)

As an aid in the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati, and E. maxima; and for the control of complicated chronic respiratory disease (CRD or air-sac infection) caused by Mycoplasma gallisepticum and Escherichia coli in broiler chickens.

Feed continuously as sole ration. Withdraw 72 hours before slaughter. Do not feed to laying chickens. Do not feed to chickens over 16 weeks of age. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Do not allow horses other equines, mature turkeys, or guinea fowl access to feed containing monensin. Ingestion of monensin by horses andguinea fowl has been fatal. In the absence of coccidiosis in broiler chickens, use of monensin with no withdrawal period may limit feed intake, resulting in reduced weight gain. Not for replacement chickens intended to become breeding chickens.

Coban™/TM®

Chickens (broilers)

As an aid in the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati, and E. maxima; and as an aid in the reduction of mortality due to air-sacculitis (air-sac infection) caused by Escherichia coli sensitive to oxytetracycline in broiler chickens.

Feed for 5 days as the sole ration. Treat at first clinical signs of disease. Withdraw 72 hours before slaughter. Do not feed to laying chickens. Do not feed to chickens over 16 weeks of age. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Do not allow horses other equines, mature turkeys, or guinea fowl access to feed containing monensin. Ingestion of monensin by horses and guinea fowl has been fatal. In the absence of cocciodiosis in broiler chickens, use of monensin with no withdrawal period may limit feed intake, resulting in reduced weight gain. Not for replacement chickens intended to become breeding chickens.

Coban™/TM®

Chickens (broilers)

As an aid in the reduction of mortality due to air-sacculitis (air-sac infection) caused by Escherichia coli sensitive to oxytetracycline; for the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti E. mivati, and E. maxima.

Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Feed for 5 days as sole ration. Treat at first clinical signs of disease. Do not feed to laying chickens. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Withdraw 24 hours prior to slaughter. Do not use in feeds containing pellet binders. May be fatal if accidentally fed to adult turkeys or to horses.

Sacox® / Terramycin®

Chickens (broilers)

As an aid in the reduction of mortality due to air-sacculitis (air-sac-infection) caused by Escherichia coli sensitive to oxytetracycline.

Feed for 5 days as sole ration. Treat at first clinical signs of disease. Do not feed to laying hens. Withdraw 24 hours prior to slaughter.

Terramycin® Premix

Chickens (broilers and breeding chickens)

It is used for the treatment of air sacculitis (air-sac disease chronic respiratory disease) caused by Mycoplasma gallisepticum and Escherichia coli; fowl cholera caused by Pasteurella multocida; infectious sinusitis caused by Mycoplasma gallisepticum; and infectious synovitis caused by Mycoplasma synoviae.

Treatment of all diseases should be instituted early. Treatment should continue for 24 to 48 hours beyond the remission of disease symptoms, but not exceed a total of 4 consecutive days. If no improvement is noted within 24 to 48 hours, diagnosis and therapy should be reevaluated. Treatment must be discontinued at least 5 days prior to slaughter for chickens. Do not administer to laying hens unless the eggs are used for hatching only.

Liquamycin® Injectable

Chickens (broiler)

For chickens as an aid in the reduction of mortality due to air-sacculitis (air-sac infection) caused by Escherichia coli sensitive to oxytetracycline and for the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti E. mivati, and E. maxima.

Feed for 5 days as sole ration. Treat at first clinical signs of disease. Do not feed to laying chickens. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Withdraw 24 hours before to slaughter. Do not use in feeds containing pellet binders. May be fatal if accidentally fed to adult turkeys or to horses.

TM® plus Bio-Cox®

Broiler chickens

For reduction of mortality due to air sacculitis (air-sac-infection) caused by E. coli susceptible to oxytetracycline.

Pennox 50®

It is used for the treatment of air sacculitis (air-sac disease chronic respiratory disease) caused by Mycoplasma gallisepticum and Escherichia coli; fowl cholera caused by Pasteurella multocida; infectious sinusitis caused by Mycoplasma gallisepticum; and infectious synovitis caused by Mycoplasma synoviae.

Treatment of all diseases should be instituted early. Treatment should continue for 24 to 48 hours beyond the remission of disease symptoms, but not exceed a total of 4 consecutive days. If no improvement is noted within 24 to 48 hours, diagnosis and therapy should be reevaluated. Treatment must be discontinued at least 5 days prior to slaughter for turkeys. Do not administer to laying hens unless the eggs are used for hatching only.

Liquamycin® Injectable

For control of complicating bacterial organisms associated with bluecomb (transmissible enteritis; coronaviral enteritis) susceptible to oxytetracycline.

Feed continuously for 7 to 14 days. Withdraw 5 days before slaughter. Do not administer to turkeys producing eggs for human consumption.

TM-50®

Control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis).

Administer for 7 to 14 days; do not slaughter for food within 4 days of treatment; not for use in turkeys producing eggs for human consumption; prepare a fresh solution daily; use as the sole source of tetracycline.

OXY WS™

For the control of infectious synovitis caused by Mycoplasma synoviae susceptible to oxytetracycline.

Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption. Use as the sole source of oxytetracycline. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

AGRIMYCIN®-343

For the control of hexamitiasis caused by Hexamita meleagridis susceptible to oxytetracycline.

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of oxytetracycline. Use as a sole source of drinking water. Do not use in birds producing eggs for human consumption. Withdraw 5 days before slaughter.

Tetroxy® 343

Turkeys (growing)

For the control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis) susceptible to oxytetracycline.

Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption. Use as the sole source of oxytetracycline. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

AGRIMYCIN®-343

Turkeys (growing)

For control of hexamitiasis caused by Hexamita meleagridis susceptible to oxytetracycline.

Feed continuously for 7 to 14 days. Do not administer to turkeys producing eggs for human consumption.

TM-50® D

Turkeys (growing)

For control of infectious synovitis caused by M. synoviae susceptible to oxytetracycline.

Feed continuously for 7 to 14 days. Withdraw 5 days before slaughter. Do not administer to turkeys producing eggs for human consumption.

TM-50® D

Turkeys (Growing)

Control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis) susceptible to oxytetracycline.

Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption.

TERRAMYCIN-343®

Finfish fry and fingerlings

For skeletal marking of finfish fry and fingerlings.

Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

Tetroxy® 343

Finfish

For skeletal marking of finfish fry and fingerlings.

Solution should be tested on a small number of fish before full-scale use. Do not discharge marking immersion water containing oxytetracycline into surface waters. Oxytetracycline HCl will acidify the water. The pH should be maintained at an acceptable level for fish by the addition of a buffer. Monitor water quality and temperature.

TERRAMYCIN-343®

Pacific Salmon

For marking of skeletal tissue.

For salmon not over 30 grams body weight. Administer as sole ration for 4 consecutive days.

Terramycin® 100 for Fish

Freshwater-reared salmonids

Control of ulcer disease caused by Haemophilus piscium, furunculosis caused by Aeromonas salmonicida, bacterial hemorrhagic septicemia caused by Aeromonas hydrophila, and pseudomonas disease.

Administer in mixed ration for 10 days.

Terramycin® 100 for Fish

Freshwater-reared salmonids

Control of mortality due to coldwater disease associated with Flavobacterium psychrophilum.

Administer in mixed ration for 10 days.

Terramycin® 100 for Fish

Freshwater-reared salmonids

Control of mortality due to columnaris disease associated with Flavobacterium columnare.

Administer in mixed ration for 10 days.

Terramycin® 100 for Fish

Catfish

Control of bacterial hemorrhagic septicemia caused by Aeromonas hydrophila and pseudomonas disease.

Administer in mixed ration for 10 days. Do not administer when water temperature is below 16.7 degrees C (62 degrees F).

Terramycin® 100 for Fish

Catfish

Control of mortality due to columnaris disease associated with Flavobacterium columnare

Terramycin® 100 for Fish

Freshwater-reared salmonids weighing up to 55 grams

For marking the skeletal tissue.

Terramycin® 200 for Fish

Terramycin Ophthalmic Ointment with Polymyxin B Sulfate is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A. aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions which may occur secondary to other infectious diseases in the above species.

Terramycin®

For treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by Escherichia coli susceptible to neomycin.

Feed continuously for 7-14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. Withdraw 5 days before slaughter.

Neo-Oxy 100/100 MR®

Treatment of bacterial enteritis caused by E. coli and bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin.

Feed continuously for 7-14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100

For treatment of bacterial enteritis caused by E. coli and bacterial pneumonia caused by P. multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin.

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

Control and treatment of bacterial enteritis caused by E. coli and bacterial pneumonia (shipping fever complex) caused by P. multocida susceptible to oxytetracycline.

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Prepare a fresh solution daily. Administer up to 14 days. Do not use for more than 14 consecutive days. Use as a sole source of oxytetracycline. Withdraw 5 days prior to slaughter.

Tetroxy® 343

For treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline.

Feed continuously for 7 to 14 days. Withdrawal 5 days before slaughter.

Terramycin® 10

For control of American Foulbrood caused by Paenibacillus larvae, and European Foulbrood caused by Melissococcus plutonius susceptible to oxytetracycline.

Terramycin® 100MR

Control of American foul brood caused by Paenibacillus larvae susceptible to oxytetracycline.

Tetroxy® 343

Honey Bees

For control of American Foulbrood caused by Paenibacillus larvae and European Foulbrood caused by Melissococcus plutonius susceptible to oxytetracycline.

Remove at least 6 weeks prior to main honey flow.

TM-50® D

Honey Bees

Control of American foul brood caused by Paenibacillus larvae susceptible to oxytetracycline.

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. The drug is administered in 3 applications of sugar syrup or 3 dustings at 4- to 5- days intervals. The drug should be fed early in the spring or fall and consumed by the bees before main honey flow begins to avoid contamination of production honey. Remove at least 6 weeks prior to main honey flow. Dusting of uncapped brood cells has been reported to cause death of larval honey bees. Do not dust uncapped brood cells.

Pennox 343®

Honey Bees

Control and treatment of American foul brood caused by Paenibacillus larvae.

The drug is administered in 3 applications of sugar syrup or 3 dustings at 4- to 5- day intervals. The drug should be fed early in the spring or fall and consumed by the bees before main honey flow begins to avoid contamination of production honey. Remove at least 6 weeks prior to main honey flow. Dusting of uncapped brood cells has been reported to cause death of larval honey bees. Do not dust uncapped brood cells.

TERRAMYCIN-343®

Honey Bees

Control of American foul brood caused by Paenibacillus larvae.

The drug is administered in 3 applications of sugar syrup or 3 dustings at 4- to 5- day intervals. The drug should be fed early in the spring or fall and consumed by the bees before main honey flow begins to avoid contamination of production honey. Remove at least 6 weeks prior to main honey flow. Dusting of uncapped brood cells has been reported to cause death of larval honey bees. Do not dust uncapped brood cells.

TERRAMYCIN®

It is used in dogs for the treatment of bacterial pneumonia caused by Brucella bronchiseptica, tonsillitis caused by Streptococcus hemolyticus, bacterial enteritis caused by Escherichia coli, urinary tract infections caused by Escherichia coli, and wound infections caused by Staphylococcus aureus. The drug can be used for continuation of compatible antibiotic therapy following parenteral oxytetracycline administration where rapidly attained, sustained antibiotic blood levels are required. The duration of treatment required to obtain favorable response will depend to some extent on the severity and degree of involvement and the susceptibility of the infectious agent. Clinical response to antibiotic therapy usually occurs within 48 to 72 hours. If improvement is not observed within that period, the diagnosis and course of treatment should be reconsidered. To assure adequate treatment, administration of the drug should continue for at least 48 hours following favorable clinical response.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Terramycin® Vet Capsules

Terramycin Ophthalmic Ointment with Polymyxin B Sulfate is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A. aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions which may occur secondary to other infectious diseases in the above species.

Terramycin®

The drug is indicated for use in the treatment of diseases of dogs caused by pathogens sensitive to oxytetracycline hydrochloride including treatment for the following conditions in dogs caused by susceptible microorganisms: Bacterial infections of the urinary tract caused by Hemolytic Staphylococcus species, Streptococcus species, Bacterial pulmonary infections caused by Brucella bronchiseptica, Streptococcus pyogenes, Staphylococcus aureus, secondary bacterial infections caused by Micrococcus pyogenes var. albus, Brucella bronchiseptica, Streptococcus species.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Aquachel 100 mg

The drug is indicated for relief of discomfort and continued treatment of many allergic, infectious, and traumatic skin conditions. The indications include prevention of bacterial infections in superficial wounds, cuts, and abrasions, treatment of allergic dermatoses, including urticaria, eczemas, insect bites, and cutaneous drug reactions, infections associated with minor burns and wounds, and nonspecific pruritus in dogs.

Keep away from eyes or other mucous membranes. Avoid inhaling. Use with adequate ventilation. In case of deep or puncture wounds or serious burns, consult a veterinarian.

Liqua-Cortril Spray

It is used in cats for the treatment of bacterial pneumonia caused by Brucella bronchiseptica, tonsillitis caused by Streptococcus hemolyticus, bacterial enteritis caused by Escherichia coli, urinary tract infections caused by Escherichia coli, and wound infections caused by Staphylococcus aureus. The drug can be used for continuation of compatible antibiotic therapy following parenteral oxytetracycline administration where rapidly attained, sustained antibiotic blood levels are required. The duration of treatment required to obtain favorable response will depend to some extent on the severity and degree of involvement and the susceptibility of the infectious agent. Clinical response to antibiotic therapy usually occurs within 48 to 72 hours. If improvement is not observed within that period, the diagnosis and course of treatment should be reconsidered. To assure adequate treatment, administration of the drug should continue for at least 48 hours following favorable clinical response.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Terramycin® Vet Capsules

Terramycin Ophthalmic Ointment with Polymyxin B Sulfate is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A. aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions which may occur secondary to other infectious diseases in the above species.

Terramycin®

The drug is indicated for relief of discomfort and continued treatment of many allergic, infectious, and traumatic skin conditions. The indications include prevention of bacterial infections in superficial wounds, cuts, and abrasions, treatment of allergic dermatoses, including urticaria, eczemas, insect bites, and cutaneous drug reactions, infections associated with minor burns and wounds, and nonspecific pruritus in cats.

Keep away from eyes or other mucous membranes. Avoid inhaling. Use with adequate ventilation. In case of deep or puncture wounds or serious burns, consult a veterinarian.

Liqua-Cortril Spray

Lobster

Control of gaffkemia caused by Aerococcus viridans.

Administer as sole ration for 5 consecutive days.

Terramycin® 100 for Fish

Lobsters

For control of gaffkemia caused by Aerococcus viridans.

Administer as sole ration for 5 consecutive days. Withdraw medicated feed 30 days before harvesting lobsters.

TM-50®

Terramycin Ophthalmic Ointment with Polymyxin B Sulfate is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A. aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions which may occur secondary to other infectious diseases in the above species.

Terramycin®

INDICATIONS FOR USE Use Level of Oxytetracycline lbs. of Pennox 100 Hi-Flo® per ton Approved by FDA under NADA # 138-938 Pennox 100 Hi-Flo® is the registered trademark of Pharmgate Inc. Chickens For Chickens: Control of infectious synovitis caused by Mycoplasma synoviae, control of fowl cholera caused by Pasteurella multocida sensitive to oxytetracycline. (Feed continuously for 7 - 14 days) 100-200 g/ton 1.0 – 2.0 For Chickens: Control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and Escherichia coli susceptible to oxytetracycline. (Feed continuously for 7 - 14 days). 400 g/ton 4.0 For Broiler Chickens: Reduction of mortality due to air sacculitis (air sac infection) caused by Escherichia coli susceptible to oxytetracycline (Feed continuously for 5 days). 500 g/ton 5.0 Withdrawal Periods and Residue Warnings: Do not feed to chickens producing eggs for human consumption. Do not use in low calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. 24 hour withdrawal period at 500 g/ton use levels. No withdrawal period is required when used according to labeling at 100 – 200 g/ton and 400 g/ton use levels. Turkeys For Turkeys: Control of hexamitiasis caused by Hexamita meleagridis susceptible to oxytetracycline. (Feed continuously for 7 - 14 days). 100 g/ton 1.0 For Turkeys: Control of infectious synovitis caused by Mycoplasma synoviae susceptible to oxytetracycline (Feed continuously for 7 - 14 days) 200g/ton 2.0 For Turkeys: Control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis) susceptible to oxytetracycline. (Feed continuously for 7 - 14 days) 25 mg/lb. body weight/day Withdrawal Periods and Residue Warnings: Do not feed to turkeys producing eggs for human consumption. Zero-day withdrawal period. Swine For Swine: Treatment of bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis susceptible to oxytetracycline and treatment of bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline. (Feed continuously for 7-14 days.) Feed approximately 400 g/t, varying with body weight and feed consumption to provide 10 mg/lb. body weight/ day For Breeding Swine: Control and treatment of leptospirosis (reducing the incidence of abortion and shedding of leptospirae) caused by Leptospira pomona susceptible to oxytetracycline. (Feed continuously for 14 days) Feed approximately 400 g/t, varying with body weight and feed consumption to provide 10 mg/lb. body weight/ day Withdrawal Periods: Zero-day withdrawal period. Calves, Beef Cattle, and Nonlactating Dairy Cattle For Growing cattle (over 400 lbs.): For the reduction of the incidence of liver abscesses. (Use continuously) 75 mg/head/day For Cattle: For the prevention and treatment of the early stages of the shipping fever complex. (Feed 3-5 days before and after arrival in feedlots.) 0.5-2.0g/head/day For Calves, Beef Cattle, and Nonlactating Dairy Cattle: Treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline. (Feed continuously for 7-14 days) 10 mg/lb. body weight/day Withdrawal Periods and Residue Warnings: This drug product is not approved for use in female cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residue in milk and/or in calves born to these cows. 5-day withdrawal period at 10 mg/lb. body weight/day use level. No withdrawal period is required when used according to labeling at 75 mg/head/day and 0.5-2.0g/head/day use levels. Sheep For Sheep: Treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline. (Feed continuously for 7-14 days) 10 mg/lb. body weight/day Withdrawal Periods: 5-day withdrawal period. Honey Bees Control of American Foulbrood caused by Paenibacillus larvae and European Foulbrood caused by Melissococcus plutonius susceptible to oxytetracycline. 200 mg/oz (Dusting) 200 mg/5 lb (Syrup) 800 mg/patty (Extender Patty) See Mixing, Preparation and Feeding Directions below. Mixing Directions for Honey Bees To manufacture a Type B medicated feed containing 20g/lb of oxytetracycline hydrochloride activity, mix 5 lb of Pennox 100 Hi-Flo with 20 lb of powdered sugar (for a total of 25 lb.) To manufacture a Type C medicated feed containing 200 mg of oxytetracycline hydrochloride activity per oz (dusting Type C medicated feed), mix 7 lb of Pennox 100 Hi-Flo with 211 lb of powdered sugar (for a total of 218 lb). The resulting Type C medicated feed is fed as-is for dusting, or is used to prepare syrup and extender patty feeds. Feeding Directions for Dusting: Dusting: Apply 1 oz (200 mg oxytetracycline) of dusting Type C medicated feed per colony every 4 to 5 days for a total of 3 applications. Apply the dust on the outer parts or ends of the frames. Caution: Dusting of uncapped brood cells has been reported to cause death of larval honey bees. Do not dust uncapped brood cells. Preparation and Feeding Directions for Syrup: Preparation: First dissolve 1 oz (200 mg oxytetracycline) of the dusting Type C medicated feed in a small quantity of water, then mix into 5 lb of 1:1 sugar syrup (equal parts sugar and water, w/w). Feeding: Feed 5 lb of syrup (200 mg oxytetracycline) per colony every 4 to 5 days for a total of 3 applications. Bulk feed the syrup using feeder pails, or division board feeders, or by filling the combs. Prepare fresh syrup for each application. Preparation and Feeding Directions for Extender Patty: Preparation: Make one patty by mixing 4 oz (800 mg oxytetracycline) of the dusting Type C medicated feed with 5.8 oz (165 g) of vegetable shortening and 11.6 oz (330 g) of sugar. Feeding: Place one patty per colony on the top bars of the brood nest frames in a single application. Warnings: Withdrawal Periods and Residue Warnings: Remove at least 6 weeks prior to main honey flow. Type C medicated feeds should be fed in the spring or fall and consumed by the bees before main honey flow begins to avoid contamination of production honey. Honey stored during medication periods in combs for surplus honey should be removed following final mediation of the bee colony and must not be used for human food. Waring: Do not use in a manner contrary to state apiary laws and regulations. Each state has specific regulations relative to disease control and medication. Contact the appropriate official or state departments of agriculture for specific inter- and intrastate laws and regulations.

Pennox 100 Hi-Flo®

Indications For Use Use Level of Oxytetracycline and Neomycin Sulfate lbs. of Neo-Oxy 50/50® per ton of Type C Medicated Feed Chickens For control of infectious synovitis caused by Mycoplasma synoviae, control of fowl cholera caused by Pasteurella multocida susceptible to oxytetracycline. Feed continuously for 7-14 days. 100-200g/ton 2.0-4.0 For control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and Escherichia coli susceptible to oxytetracycline. Feed continuously for 7-14 days. 400g/ton 8.0 For reduction of mortality due to air sacculitis (air sac infection) caused by Escherichia coli susceptible to oxytetracycline. Feed continuously for 5 days. 500g/ton 10.0 RESIDUE WARNING: AT 500 G/TON LEVEL, WITHDRAW 24 HOURS BEFORE SLAUGHTER. ZERO-DAY WITHDRAWAL PERIOD FOR LOWER USE LEVELS. IN LOW CALCIUM FEEDS WITHDRAW 3 DAYS BEFORE SLAUGHTER. DO NOT FEED TO CHICKENS PRODUCING EGGS FOR HUMAN CONSUMPTION. Turkeys For control of hexamitiasis caused by Hexamita meleagridis susceptible to oxytetracycline. Feed continuously for 7-14 days. 100g/ton 2.0 For control of infectious synovitis caused by Mycoplasma synoviae susceptible to oxytetracycline. Feed continuously for 7-14 days. 200g/ton 4.0 For control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis) susceptible to oxytetracycline. Feed continuously for 7-14 days. 25 mg/lb body weight/day 16.7If bird weighs 10 lb, consuming 0.6 lb of complete feed per day RESIDUE WARNING: AT 200 G/TON USE LEVEL OR HIGHER, WITHDRAW 5 DAYS BEFORE SLAUGHTER. ZERO-DAY WITHDRAWAL PERIOD AT 100G/TON USE LEVELS. DO NOT FEED TO TURKEYS PRODUCING EGGS FOR HUMAN CONSUMPTION. Sheep For treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by Escherichia coli susceptible to neomycin. Feed continuously for 7-14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. 10 mg/lb body weight/day 24If lamb weighs 60 lb, consuming 1 lb of supplement per head per day RESIDUE WARNING: WITHDRAW 5 DAYS BEFORE SLAUGHTER AT 10 MG/LB DOSAGE. Swine For Swine: For treatment of bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis and treatment of bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by Escherichia coli susceptible to neomycin. Feed continuously for 7-14 days. 10 mg/lb body weight/day 10If pig weighs 100 lb, consuming 4 lb of complete feed per day For Breeding Swine: For control and treatment of leptospirosis (reducing the incidence of abortion and shedding of leptospirae) caused by Leptospira pomona susceptible to oxytetracycline. Feed continuously for not more than 14 days. 10 mg/lb body weight/day 10 RESIDUE WARNING: WITHDRAW 5 DAYS BEFORE SLAUGHTER AT 10 MG/LB DOSAGE. Calves, Beef Cattle, and Nonlactating Dairy Cattle For Calves (up to 250 lbs.): For treatment of bacterial enteritis caused by Escherichia coli susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by Escherichia coli susceptible to neomycin. Feed continuously for 7 to 14 days in starter feed. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. 10 mg/lb body weight/day 20If calf weighs 100 lb, consuming 2 lb of complete starter feed per day For Growing Cattle (over 400 lbs.): For the reduction of the incidence of liver abscesses. Feed continuously. 75mg/head/day 1.5Include in feed supplement based on consumption of 2 lb of supplement per head per day For prevention and treatment of the early stages of shipping fever complex. Feed 3-5 days before and after arrival in feedlots. 0.5-2.0g/head/day 10-40 For treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by Escherichia coli susceptible to neomycin. Feed continuously for 7-14 days in feed. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. 10 mg/lb body weight/day 100If animal weighs 500 lb, consuming 2 lb of supplement per head per day RESIDUE WARNING: AT 0.5-2.0 G/HEAD/DAY AND 10 MG/LB DOSAGES: A WITHDRAWAL PERIOD HAS NOT BEEN ESTABLISHED FOR USE IN PRE-RUMINATING CALVES. DO NOT USE IN CALVES TO BE PROCESSED FOR VEAL. AT 0.5-2.0 G/HEAD/DAY AND 10 MG/LB DOSAGES: A MILK DISCARD TIME HAS NOT BEEN ESTABLISHED FOR USE IN LACTATING DAIRY CATTLE. DO NOT USE IN FEMALE DAIRY CATTLE 20 MONTHS OF AGE OR OLDER. AT 10 MG/LB DOSAGE, WITHDRAW 5 DAYS BEFORE SLAUGHTER. USE OF MORE THAN ONE PRODUCT CONTAINING NEOMYCIN OR FAILURE TO FOLLOW WITHDRAWAL TIMES MAY RESULT IN ILLEGAL DRUG RESIDUES. Store at or below 25°C (77°F) with excursions permitted to 37°C (98.6°F) Approved by FDA under NADA # 138-939

Neo-Oxy 50/50®

Indications and Directions For Use For the control of the following poultry diseases caused by organisms susceptible to oxytetracycline. Add the following amount to ten gallons of stock solution when proportioner is set to meter at the rate of one ounce per gallon. Chickens Dosage Packs/10 Gallons Stock Solution Infectious synovitis caused by Mycoplasma synoviae 200-400 mg/gal ½ - 1 Chronic respiratory disease (CRD) and air-sac infection caused by Mycoplasma gallisepticum and Escherichia coli 400-800 mg/gal 1-2 Fowl cholera caused by Pasteurella multocida 400-800 mg/gal 1-2 Turkeys Hexamitiasis caused by Hexamita meleagridis 200-400 mg/gal ½ - 1 Infectious synovitis caused by Mycoplasma synoviae 400 mg/gal 1 Growing Turkeys – Complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis) 25 mg/lb body weight daily Varies with age & water consumption (1 pack will treat 20,480 lbs of turkeys) Medicate continuously at the first clinical signs of disease and continue for 7-14 consecutive days. If improvement is not noted within 24-48 hours, consult a veterinarian or a diagnostic laboratory to determine diagnosis and advice on dosage. See Residue Warnings. Finfish For the marking of skeletal tissues in finfish fry and fingerlings. Immerse in 200-700mg oxytetracycline HCl (buffered)/L of water for 2-6 hours. Solution should be tested on a small number of fish before full-scale use. See Residue Warnings. DISPOSAL OF TREATED WATERS: Do not discharge marking immersion water containing oxytetracycline into surface waters. ADVERSE REACTIONS: Oxytetracycline HCl will acidify the water. The pH should be maintained at an acceptable level for fish by the addition of a buffer. Monitor water quality and temperature. Swine Dosage Bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis Bacterial pneumonia caused by Pasteurella multocida For Breeding Swine: Leptospirosis (reducing the incidence of abortions and shedding of leptospira) caused by Leptospira Pomona Administer in the drinking water at a level of 10 mg oxytetracycline HCl per lb of body weight daily. Administer up to 5 days. See Residue Warnings. Calves, Beef Cattle and Non-Lactating Dairy Cattle Bacterial enteritis caused by Escherichia coli Bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida Do not mix this product with milk or milk replacers. Administer one hour before or two hours after feeding milk or milk replacers. Administer in the drinking water at a level of 10mg oxytetracycline HCl per lb of body weight daily. Administer up to 5 days. See Residue Warnings. Sheep Bacterial enteritis caused by Escherichia coli Bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida Administer in the drinking water at a level of 10mg oxytetracycline HCl per lb of body weight daily. Administer up to 5 days. See Residue Warnings. This packet will treat 51,200 lbs of swine, cattle or sheep at 10 mg/lb. Honey Bees For control of American Foulbrood caused by Paenibacillus larvae susceptible to oxytetracycline. CONTRAINDICATION: Dusting of uncapped brood cells has been reported to cause death of larval honey bees. Do not dust uncapped brood cells. 200 mg/colony Administer in 3 applications of 1:1 sugar syrup (equal parts of sugar and water weight to weight) or 3 dustings at 4-5 day intervals. Apply dust on the outer parts or ends of the frames. See Residue Warnings.

Pennox 343® (oxytetracycline HCl) Soluble Powder

Mixing and Use Directions Mix Neo-Oxy 100/100 MR® with non-medicated milk replacer to provide the following concentrations: INDICATIONS FOR USE Use Level of Oxytetracycline and Neomycin lbs. of Neo-Oxy 100/100 MR per ton of Type C Medicated Feed Mixing directions are for example only and are based on mixing 1 lb of dry milk replacer with 1 gallon of water. Calves (milk replacer) For Calves (up to 250 lb): For treatment of bacterial enteritis caused by Escherichia coli susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by Escherichia coli susceptible by neomycin. Feed continuously for 7-14 days in milk replacer or starter feed. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. 10 mg/lb body weight/day 20If calf weighs 100 lb, consuming 1 gallon of milk replacer per day. RESIDUE WARNING: A WITHDRAWAL PERIOD HAS NOT BEEN ESTABLISHED FOR USE IN PRERUMINATING CALVES. DO NOT USE IN CALVES TO BE PROCESSED FOR VEAL. A MILK DISCARD TIME HAS NOT BEEN ESTABLISHED FOR USE IN LACTATING DAIRY CATTLE. DO NOT USE IN FEMALE DAIRY CATTLE 20 MONTHS OR OLDER, INCLUDING DRY DAIRY COWS. USE IN THESE CATTLE MAY CAUSE DRUG RESIDUES IN MILK AND/OR IN CALVES BORN TO THESE COWS. WITHDRAW 5 DAYS BEFORE SLAUGHTER. USE OF MORE THAN ONE PRODUCT CONTAINING NEOMYCIN OR FAILURE TO FOLLOW WITHDRAWAL TIMES MAY RESULT IN ILLEGAL DRUG RESIDUES Calves, Beef Cattle, and Nonlactating Dairy Cattle For treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by Escherichia coli susceptible by neomycin. Feed continuously for 7-14 days in feed or milk replacers. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. 10 mg/lb body weight/day 20 RESIDUE WARNINGS: A WITHDRAWAL PERIOD HAS NOT BEEN ESTABLISHED FOR USE IN PRERUMINATING CALVES. DO NOT USE IN CALVES TO BE PROCESSED FOR VEAL. A MILK DISCARD TIME HAS NOT BEEN ESTABLISHED FOR USE IN LACTATING DAIRY CATTLE. DO NOT USE IN FEMALE DAIRY CATTLE 20 MONTHS OR OLDER, INCLUDING DRY DAIRY COWS. USE IN THESE CATTLE MAY CAUSE DRUG RESIDUES IN MILK AND/OR IN CALVES BORN TO THESE COWS. WITHDRAW 5 DAYS BEFORE SLAUGHTER. USE OF MORE THAN ONE PRODUCT CONTAINING NEOMYCIN OR FAILURE TO FOLLOW WITHDRAWAL TIMES MAY RESULT IN ILLEGAL DRUG RESIDUES Store at or below 25°C (77°F) with excursions permitted to 37°C (98.6°F). Approved by FDA under NADA # 138-939

Neo-Oxy 100/100 MR®

Medicate continuously at the first clinical signs of disease and continue for 7 to 14 consecutive days. If improvement is not noted within 24-48 hours, consult a poultry diagnostic laboratory or poultry pathologist to determine diagnosis and advice on dosage. See Residue Warnings. For the control and treatment of the following diseases caused by organisms susceptible to oxytetracycline: SWINE DOSAGE Bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis. Bacterial pneumonia caused by Pasteurella multocida. For Breeding Swine: Leptospirosis (reducing the incidence of abortions and shedding of leptospira) caused by Leptospira pomona. Administer in the drinking water at a level of 10 mg oxytetracycline hydrochloride per pound of body weight daily. Administer up to 14 days. See Residue Warnings. CALVES, BEEF CATTLE AND NON-LACTATING CATTLE DOSAGE Bacterial enteritis caused by Escherichia coli. Bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida. Administer in the drinking water at a level of 10 mg oxytetracycline hydrochloride per pound of body weight daily. Administer up to 14 days. See Residue Warnings. SHEEP DOSAGE Bacterial enteritis caused by Escherichia coli. Bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida. Administer in the drinking water at a level of 10 mg oxytetracycline hydrochloride per pound of body weight daily. Administer up to 14 days. See Residue Warnings. This bucket will treat 171,500 pounds of swine, cattle or sheep at 10 mg/pound. HONEY BEES DOSAGE For control of American Foulbrood caused by Paenibacillus larvae susceptible to oxytetracycline. 200 mg/colony Administer in 3 applications of sugar syrup or 3 dustings at 4 to 5 day intervals. Apply dust on the outer parts or ends of the frames. See Residue Warnings. CONTRAINDICATION: Dusting of uncapped brood cells has been reported to cause death of larval honey bees. Do not dust uncapped brood cells. FISH DOSAGE For the marking of skeletal tissues in finfish fry and fingerlings as an aid in identification. Immerse fry or fingerling finfish in 200 to 700 mg OTC (buffered)/liter of water for 2-6 hours. Solution should be tested on a small number of fish before full-scale use. Once mixed with water, solution should be used immediately. See Residue Warnings.

FDA application 200-247

INDICATIONS: Vetrimycin™ 200 (oxytetracycline injection) is intended for use in the treatment of the following diseases in beef cattle; dairy cattle; calves, including preruminating (veal) calves; and swine when due to oxytetracycline-susceptible organisms: Cattle: Vetrimycin™ 200 (oxytetracycline injection) is indicated in the treatment of pneumonia and shipping fever complex associated with Pasteurella spp. and Haemophilus spp; infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis; foot rot and diphtheria caused by Fusobacterium necrophorum; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresii; leptospirosis caused by Leptospira pomona; and wound infections and acute metritis caused by strains of staphylococci and streptococci organisms sensitive to oxytetracycline. Swine: Vetrimycin™ 200 is indicated in the treatment of bacterial enteritis (scours, colibacillosis) caused by Escherichia coli; pneumonia caused by Pasteurella multocida; and leptospirosis caused by Leptospira pomona. In sows, Vetrimycin™ 200 is indicated as an aid in the control of infectious enteritis (baby pig scours, colibacillosis) in suckling pigs caused by Escherichia coli.

FDA application 200-128

INDICATIONS AND DIRECTIONS FOR USE: POULTRY For the control of the following poultry diseases caused by organisms susceptible to oxytetracycline: Add the following amount to two gallons of stock solution when proportioner is set to meter at the rate of one ounce per gallon. The enclosed measuring cup holds 68 g (2.4 oz) of product when leveled at the 80 mL mark. CHICKENS DOSAGE SCOOPS/2 GALLONS STOCK SOLUTION Infectious synovitis caused by Mycoplasma synoviae. 200-400 mg/gal 1-2 Chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and Escherichia coli. 400-800 mg/gal 2-4 Fowl cholera caused by Pasteurella multocida. 400-800 mg/gal 2-4 TURKEYS Hexamitiasis caused by Hexamita meleagridis. 200-400 mg/gal 1-2 Infectious synovitis caused by Mycoplasma synoviae. 400 mg/gal 2 Growing Turkeys-Complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis). 25 mg/lb body weight daily varies with age & water consumption (1 pound will treat 13,720 pounds of turkeys.)

FDA application 200-247

Noromycin 300 LA is intended for use in treatment for the following diseases when due to oxytetracycline-susceptible organisms: Beef cattle, non-lactating dairy cattle, calves, including pre-ruminating (veal) calves: Noromycin 300 LA is indicated in the treatment of pneumonia and shipping fever complex associated with Pasteurella spp., and Histophilus spp. Noromycin 300 LA is indicated for the treatment of infectious bovine keratoconjunctivitis (pink eye) caused by Moraxella bovis, foot-rot and diphtheria caused by Fusobacterium necrophorum; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresii; leptospirosis caused by Leptospira pomona; and wound infections and acute metritis caused by strains of staphylococcal and streptococcal organisms sensitive to oxytetracycline. Also, it is indicated for the control of respiratory disease in cattle at high risk of developing BRD associated with Mannheimia (Pasteurella) haemolytica.

FDA application 141-143

USE DIRECTIONS: Mix fresh solutions daily. Use as the sole source of drinking water. Do not mix this product directly with milk or milk replacers. Administer 1 hour before or 2 hours after feeding milk or milk replacers. As a generalization, 200 chickens will drink 1 gallon of water per day for each week of age. Turkeys will consume twice that amount. Administer up to 5 days to swine and 7 to 14 days for chickens and turkeys. NOTE: The concentration of drug required in medicated water must be adequate to compensate for variation in the age of the animal, feed consumption rate, and the environmental temperatures and humidity, each of which affects water consumption.

FDA application 130-435

Terramycin is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A. aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions which may occur secondary to other infectious diseases in the above species.

Terramycin®

Terramycin Scours Tablets are recommended for oral administration for the control and treatment of the following diseases in beef and dairy calves caused by organisms sensitive to oxytetracycline: bacterial enteritis caused by Salmonella typhimurium and Escherichia coli (colibacillosis) and bacterial pneumonia (shipping fever complex, pasteurellosis) caused by Pasteurella multocida.

Terramycin® Scours Tablets

Oxytetracycline Injection 200 is intended for use in the treatment of the following diseases in beef cattle; dairy cattle; calves, including preruminating (veal) calves; and swine when due to oxytetracycline-susceptible organisms:

OXYTETRACYCLINE INJECTION 200(oxytetracycline injection)

FOR USE IN ANIMAL FEEDS ONLY NOT FOR HUMAN USE RESTRICTED DRUG (CALIFORNIA) – USE ONLY AS DIRECTED

Neo-Terramycin® 100/100 (neomycin-oxytetracycline) TYPE A MEDICATED ARTICLE

NOT FOR HUMAN USE RESTRICTED DRUG (CALIFORNIA) – USE ONLY AS DIRECTED

Terramycin® 200 for Fish TYPE A MEDICATED ARTICLE

FOR USE IN THE MANUFACTURE OF MEDICATED ANIMAL FEEDS

Neo-Oxy 50/50®

NOT FOR HUMAN USE

Terramycin® 200 (oxytetracycline) TYPE A MEDICATED ARTICLE

Oxytetracycline is derived from the metabolic activity of the actinomycete, Streptomyces rimosus. Oxytetracycline is an antimicrobial agent that is effective in the treatment of a wide range of diseases caused by susceptible gram-positive and gram-negative bacteria. The antibiotic activity of oxytetracycline is not appreciably diminished in the presence of body fluids, serum or exudates. Studies have shown that the half-life of oxytetracycline in blood following intramuscular treatment with Noromycin 300 LA at 5 mg per pound of bodyweight is approximately 23 hours in cattle and 18 hours in swine. Studies have shown when Noromycin 300 LA is administered once intramuscularly to cattle or swine at 9 mg per pound of bodyweight, blood oxytetracycline concentration of greater than 0.2 mcg/mL have been observed for 3 to 4 days. Studies have shown when Noromycin 300 LA is administered once intramuscularly or subcutaneously to cattle at 13.6 mg per pound of bodyweight, blood oxytetracycline concentration of greater than 0.2 mcg/mL have been observed for at least 7 to 8 days.

FDA application 141-143

CAUTION: When administered to cattle, muscle discoloration may necessitate trimming of the injection site(s) and surrounding tissues during the dressing procedure. WARNINGS: Discontinue treatment at least 28 days prior to slaughter of cattle and swine. Milk taken from animals during treatment and for 96 hours after the last treatment must not be used for food. Rapid intravenous administration may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes. PRECAUTIONS: Exceeding the highest recommended dosage level of drug per lb of body weight per day, administering more than the recommended number of treatments, and/or exceeding 10 mL subcutaneously per injection site in adult beef and dairy cattle, and 5 mL intramuscularly per injection site in adult swine, may result in antibiotic residues beyond the withdrawal period. At the first sign of any adverse reaction, discontinue use of the product and seek the advice of your veterinarian. Some of the reactions may be attributed either to anaphylaxis (an allergic reaction) or to cardiovascular collapse of unknown cause. Shortly after injection, treated animals may have transient hemoglobinuria resulting in darkened urine. As with all antibiotic preparations, use of this drug may result in overgrowth of non-susceptible organisms, including fungi. A lack of response by the treated animal, or the development of new signs, may suggest that an overgrowth of nonsusceptible organisms has occurred. If any of these conditions occur, consult your veterinarian. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving Terra-Vet® 200 (oxytetracycline injection) in conjunction with penicillin.

FDA application 200-128

RESIDUE WARNINGS: Use as sole source of oxytetracycline. Do not administer to turkeys, cattle or sheep within 5 days of slaughter. Zero-day slaughter withdrawal in swine. Do not administer to chickens or turkeys producing eggs for human consumption. Do not administer this product with milk or milk replacers. Administer 1 hour before or 2 hours after feeding milk or milk replacers. A milk discard period has not been established for this product in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. An additional withdrawal time beyond the grow-out period is not needed for fish. For honey bees, the drug should be fed early in the spring or fall and consumed by the bees before main honey flow begins to avoid contamination of production honey. Remove at least 6 weeks prior to main honey flow. CONTACT INFORMATION: To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae

FDA application 200-247

CAUTION: Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. CAUTION: For use in manufacturing medicated fish and lobster feeds only. For use in dry feeds only. Not for use in liquid feed supplements. CAUTION: Certain components of animal feeds, including medicated premixes, possess properties that may be a potential health hazard or a source of personal discomfort to certain individuals who are exposed to them. Human exposure should, therefore, be minimized by observing the general industry standards for occupational health and safety. Precautions such as the following should be considered: dust masks or respirators and protective clothing should be worn; dust-arresting equipment and adequate ventilation should be utilized; personal hygiene should be observed; wash before eating or leaving a work site; be alert for signs of allergic reactions—seek prompt medical treatment if such reactions are suspected.

Terramycin® 200 for Fish TYPE A MEDICATED ARTICLE

CAUTION: For use in manufacturing medicated animal feeds only. For use in dry milk replacers only. CAUTION: Certain components of animal feeds, including medicated premixes, possess properties that may be a potential hazard or a source of personal discomfort to certain individuals who are exposed to them. Human exposure should, therefore, be minimized by observing the general industry standards for occupational health and safety. Precautions such as the following should be considered: dust masks or respirators and protective clothing should be worn; dust-arresting equipment and adequate ventilation should be utilized; personal hygiene should be observed; wash before eating or leaving a work site; be alert for signs of allergic reactions—seek prompt medical treatment if such reactions are suspected.

Terramycin® 100MR (oxytetracycline) TYPE A MEDICATED ARTICLE

►Withdrawal Periods and Residue Warnings: Remove at least 6 weeks prior to main honey flow. Type C medicated feeds should be fed in the spring or fall and consumed by the bees before main honey begins to avoid contamination of production honey. Honey stored during medication periods in combs for surplus honey should be removed following final medication of the bee colony and must not be used for human food. Warning: Do not use in a manner contrary to state apiary laws and regulations. Each state has specific regulations relative to disease control and medications. Contact the appropriate official or state departments of agriculture for specific inter- and intrastate laws and regulations. NOT FOR HUMAN USE. RESTRICTED DRUG (CALIFORNIA) – USE ONLY AS DIRECTED.

Terramycin® 100MR (oxytetracycline) TYPE A MEDICATED ARTICLE

CAUTION: When administered to cattle, muscle discoloration may necessitate trimming of the injection site(s) and surrounding tissues during the dressing procedure. Warnings: Discontinue treatment at least 28 days prior to slaughter of cattle and swine. Milk taken from animals during treatment and for 96 hours after the last treatment must not be used for food. Precautions: Exceeding the highest recommended level of drug per lb of body weight per day, administering more than the recommended number of treatments, and/or exceeding 10 mL subcutaneously per injection site in adult beef and dairy cattle, and 5 mL intramuscularly per injection site in adult swine, may result in antibiotic residues beyond the withdrawal period.

FDA application 200-128

RESIDUE WARNINGS: Do not administer to cattle or sheep within 5 days of slaughter. Zero day withdrawal in chickens, turkeys and swine. Do not administer to chickens or turkeys producing eggs for human consumption. A milk discard period has not been established for this product in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. An additional withdrawal time beyond the grow-out period is not needed for finfish. For honey bees, the drug should be fed early in the spring or fall and consumed by the bees before main honey flow begins to avoid contamination of production honey. Remove at least 6 weeks prior to main honey flow.

Pennox 343® (oxytetracycline HCl) Soluble Powder

Serious, life threatening, hypersensitivity (anaphylactic) reactions have been reported in some cats following application of antibiotic ophthalmic preparations. If your cat has swelling of the face, itching, appears weak, vomits, or has difficulty breathing within 4 hours of application you should discontinue treatment and contact your veterinarian immediately. Note: The use of oxytetracycline and other antibiotics may result in an overgrowth of resistant organisms such as Monilia, staphylococci, and other species of bacteria. If new infections due to nonsensitive bacteria or fungi appear during therapy, appropriate measures should be taken.

Terramycin®

WARNINGS: Discontinue treatment at least 28 days prior to slaughter of cattle and swine. Not for use in lactating dairy animals. Rapid intravenous administration may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Norbrook at 1-866-591-5777.

FDA application 141-143

Discontinue treatment at least 28 days prior to slaughter of cattle and swine. Milk taken from animals during treatment and for 96 hours after the last treatment must not be used for food. Rapid intravenous administration may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes.

VETone®Vetrimycin ™ 200

Discontinue treatment at least 7 days prior to slaughter. Not for use in lactating dairy cattle. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

Terramycin® Scours Tablets

CAUTION: Use as the sole source of oxytetracycline. Not to be used for more than 5 consecutive days in swine or 14 consecutive days in chickens and turkeys. WARNING - Do not feed to birds producing eggs for human consumption.

FDA application 130-435

CAUTION: Use as the sole source of oxytetracycline. Not to be used for more than 5 consecutive days in swine or 14 consecutive days in chickens and turkeys.

FDA application 130-435

WARNING: Do not feed to birds producing eggs for human consumption.

FDA application 200-144

Not For Human Use Approved by FDA under ANADA # 200-128

FDA application 200-128

Reports of adverse reactions associated with oxytetracycline administration include injection site swelling, restlessness, ataxia, trembling, swelling of eyelids, ears, muzzle, anus and vulva (or scrotum and sheath in males), respiratory abnormalities (labored breathing), frothing at the mouth, collapse and possibly death. Some of these reactions may be attributed to anaphylaxis (an allergic reaction) or to cardiovascular collapse of unknown cause. To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Norbrook at 1-866-591-5777. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae.

OXYTETRACYCLINE INJECTION 200(oxytetracycline injection)

Reports of adverse reactions associated with oxytetracycline administration include injection site swelling, restlessness, ataxia, trembling, swelling of eyelids, ears, muzzle, anus and vulva (or scrotum and sheath in males), respiratory abnormalities (labored breathing), frothing at the mouth, collapse and possibly death. Some of these reactions may be attributed either to anaphylaxis (an allergic reaction) or to cardiovascular collapse of unknown cause. To report a suspected adverse reaction call 1-866-591-5777.

FDA application 141-143

Questions/Comments?: For technical assistance or to report side effects, contact Huvepharma, Inc. at 1-877-994-4883 or www.huvepharma.com. For additional information about reporting side effects for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae Restricted Drug (California) - Use only as directed. KCP-S00066 (Rev. 04-2026) Approved by the FDA under NADA # 130-435

FDA application 130-435

ADVERSE REACTIONS: Oxytetracycline hydrochloride will acidify the water. The pH should be maintained at an acceptable level for fish by the addition of a buffer. Monitor water quality and temperature. DISPOSAL OF TREATED WATER: Do not discharge marking immersion water containing oxytetracycline into surface waters.

FDA application 200-247

Cattle (calves, beef, and nonlactating dairy)

10 milligrams per pound of body weight daily in drinking water.

Immersion, Oral

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Prepare a fresh solution daily. Administer up to 5 days. Do not use for more than 5 consecutive days. Use as sole source of oxytetracycline. Do not administer this product with milk or milk replacers. Administer 1 hour before or 2 hours after feeding milk or milk replacers. Withdraw 5 days prior to slaughter. A milk discard period has not been established for this product in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older.

Pennox 343®

Cattle (calves, beef, and nonlactating dairy)

10 milligrams per pound of body weight daily.

Oral

Feed continuously for 7 to 14 days. Zero-day withdrawal time.

Terramycin® 10

Cattle (calves, beef, and nonlactating dairy)

0.5 to 2.0 grams per head per day.

Oral

Feed 3 to 5 days before and after arrival in feedlots.

Terramycin® 10

Cattle (calves, beef, and nonlactating dairy)

75 milligrams per head per day.

Oral

Feed continuously.

Terramycin® 10

Cattle (beef, nonlactating dairy, and beef and dairy calves [excluding veal])

3 to 5 milligrams of oxytetracycline per pound of body weight per day (6 to 10 mL per 100 pounds of body weight) by intramuscular injection. Severe foot rot and the severe forms of the indicated diseases should be treated with 5 mg per pound of body weight. Treatment should be continued 24 to 48 hours following remission of disease symptoms, not to exceed a total of 4 consecutive days.

Intramuscular

MEDAMYCIN®

Cattle (beef, non-lactating dairy, and beef and dairy calves [excluding veal])

3 to 5 milligrams of oxytetracycline per pound of body weight per day (3 to 5 mL per 100 pounds of body weight) by intravenous injection. Severe foot rot and the severe forms of the indicated diseases should be treated with 5 mg per pound of body weight. Treatment should be continued 24 to 48 hours following remission of disease symptoms, not to exceed a total of 4 consecutive days.

Intravenous

MAXIM 100

Cattle (beef and nonlactating dairy)

Administer by intravenous or intramuscular injection at 3 to 5 milligrams of oxytetracycline per pound of body weight per day. In the treatment of severe foot-rot and severe forms of the indicated diseases, a dosage level of 5 milligrams per pound of body weight per day is recommended. If the labeling of the drug bears the statement ``Federal law restricts this drug to use by or on the order of a licensed veterinarian,'' it may include additional directions for use in beef cattle and nonlactating dairy cattle for the treatment of anaplasmosis caused by Anaplasma marginale and anthrax caused by Bacillus anthracis in which case the drug is given at 3 to 5 milligrams of oxytetracycline per pound of body weight per day for anthrax, and at 5 milligrams per pound of body weight per day for anaplasmosis.

Intravenous, Intramuscular, Subcutaneous

Treatment of all diseases should be instituted early. Treatment should continue for 24 to 48 hours beyond the remission of disease symptoms, but not exceed a total of 4 consecutive days. If no improvement is noted within 24 to 48 hours, diagnosis and therapy should be reevaluated. When injecting intramuscularly in adult livestock, do not inject more than 10 milliliters at any one site. The volume administered per injection site should be reduced according to age and body size so that 1 or 2 milliliters are injected in smaller animals such as small calves. Intravenous administration is recommended in cattle when daily dosage exceeds 50 milliliters. Treatment must be discontinued at least 22 days prior to slaughter for cattle. When administered intramuscularly to animals within 30 days of slaughter, muscle discoloration may necessitate trimming of the injection site(s) and surrounding tissues during the dressing procedure. Not for use in lactating dairy animals.

Liquamycin® Injectable

Cattle (beef and nonlactating dairy)

It is administered to cattle at a dosage level of 3 to 5 milligrams per pound of body weight per day. It is administered intravenously from a 100 milligram per milliliter solution. Severe foot-rot and the severe forms of the indicated diseases should be treated with 5 milligrams per pound of body weight. Treatment should be continued 24 to 48 hours following remission of disease symptoms, however, not to exceed a total of 4 consecutive days. If no improvement is noted within 24 hours consult a veterinarian. When injecting the drug intramuscularly do not inject more than 10 milliliters per site in adult cattle. Reduce the amount injected at each site according to the size of the animal. For very small calves do not use more than 2 milliliters per injection site.

Intravenous

Not for use in lactating dairy cattle. Discontinue treatment at least 19 days prior to slaughter. When administered intramuscularly within 30 days of slaughter, muscle discoloration may necessitate trimming of the injection site and surrounding tissues.

Aquachel-100

Cattle (beef and nonlactating dairy)

3 to 5 milligrams of oxytetracycline per pound of body weight per day, administered by intravenous or intramuscular injection. In the treatment of severe foot rot and advanced cases of other indicated diseases, a dosage level of 5 milligrams per pound of body weight per day is recommended. Treatment should be continued 24 to 48 hours following remission of disease signs, however, not to exceed a total of four consecutive days. Consult your veterinarian if improvement is not noted within 24 to 48 hours of the beginning of treatment.

Intravenous, Intramuscular

Oxytetracycline Injection

Cattle (beef and nonlactating dairy)

3 to 5 milligrams of oxytetracycline per pound of body weight per day (6 to 10 mL per 100 pounds of body weight) by intramuscular or intravenous injection. In severe forms of foot rot, anaplasmosis, and other severe disease forms, 5 milligrams per pound of body weight per day (10 mL per 100 pounds of body weight). Treatment should be continued 24 to 48 hours following remission of disease symptoms, not to exceed a total of 4 days.

Intramuscular, Intravenous

Bio-Mycin®

Cattle (beef and nonlactating dairy)

Three to 5 milligrams of oxytetracycline per pound of body weight per day; 5 milligrams per pound of body weight per day for the treatment of anaplasmosis, severe foot-rot, and severe cases of other indicated diseases. For 100-milligram-per-milliliter solution, administer intramuscularly.

Intramuscular

Treatment of all diseases should be instituted early and continue for 24 to 48 hours beyond remission of disease symptoms, but not to exceed a total of 4 consecutive days. Consult your veterinarian if no improvement is noted within 48 hours. Do not inject more than 10 milliliters per site in adult cattle, reducing the volume according to age and body size to 0.5 to 2 milliliters in small calves. Exceeding the highest recommended dose of 5 milligrams per pound of body weight, administering at recommended levels for more than 4 consecutive days, and/or exceeding 10 milliliters intramuscularly per injection site may result in antibiotic residues beyond the withdrawal time. Discontinue treatment at least 18 days prior to slaughter. Not for use in lactating dairy cattle. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and /or in calves born to these cows.

Bio-Mycin C

Cattle (beef and nonlactating dairy)

3 to 5 milligrams of oxytetracycline per pound of body weight per day; 5 milligrams per pound of body weight per day for treatment of anaplasmosis, severe foot-rot, and severe cases of other indicated diseases. Administer intramuscularly.

Intramuscular

Treatment of all diseases should be instituted early and continue for 24 to 48 hours beyond remission of disease symptoms but not to exceed a total of 4 consecutive days. Consult your veterinarian if no improvement is noted within 48 hours. Do not inject more than 10 milliliters per site in adult cattle, reducing the volume according to age and body size to 1 to 2 milliliters in small calves. Exceeding the highest recommended dose of 5 milligrams per pound of body weight, administering at recommended levels for more than 4 consecutive days, and/or exceeding 10 milliliters intramuscularly per injection site may result in antibiotic residues beyond the withdrawal time. Discontinue treatment at least 15 days prior to slaughter. Not for use in lactating dairy cattle.

Liquamycin® 100

Cattle (beef and nonlactating dairy)

A single dosage of 9 milligrams per pound of body weight administered intramuscularly.

Intravenous, Intramuscular

Oxytetracycline Injection

Cattle (calves, beef and nonlactating dairy)

10 milligrams per pound of body weight in drinking water.

Oral

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Prepare a fresh solution daily. Administer up to 14 days. Do not use for more than 14 consecutive days. Use as sole source of oxytetracycline. Do not administer this product with milk or milk replacers. Administer 1 hour before or 2 hours after feeding milk or milk replacers. Withdraw 5 days prior to slaughter. A milk discard period has not been established for this product in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older.

Tetroxy® 25

Cattle (beef cattle; dairy cattle; calves, including preruminating (veal) calves)

3 to 5 milligrams of oxytetracycline per pound of body weight per day, administered by intravenous, subcutaneous, or intramuscular injection. In the treatment of severe foot-rot and advanced cases of other indicated diseases, a dosage of 5 milligrams per pound of body weight per day is recommended. Treatment should be continued 24 to 48 hours following remission of disease signs, however, not to exceed a total of four consecutive days. Consult your veterinarian if improvement is not noted within 24 to 48 hours of the beginning of treatment.

Subcutaneous, Intravenous, Intramuscular

MAXIM-200

Cattle (beef cattle; dairy cattle; calves, including preruminating (veal) calves)

A single dosage of 9 milligrams oxytetracycline per pound of body weight administered intramuscularly or subcutaneously.

Subcutaneous, Intravenous, Intramuscular

MAXIM-200

Beef cattle, dairy cattle, and calves including prerumenative (veal) calves

3 to 5 milligrams of oxytetracycline per pound of body weight per day, administered by intravenous, subcutaneous, or intramuscular injection. In the treatment of severe foot-rot and advanced cases of other indicated diseases, a dosage of 5 milligrams per pound of body weight per day is recommended. Treatment should be continued 24 to 48 hours following remission of disease signs, however, not to exceed a total of four consecutive days. Consult your veterinarian if improvement is not noted within 24 to 48 hours of the beginning of treatment.

Subcutaneous, Intravenous, Intramuscular

Liquamycin® LA-200®

Beef cattle, dairy cattle, and calves including prerumenative (veal) calves

A single dosage of 9 milligrams oxytetracycline per pound of body weight administered intramuscularly or subcutaneously.

Subcutaneous, Intravenous, Intramuscular

Liquamycin® LA-200®

Cattle (beef and dairy)

3 to 5 milligrams of oxytetracycline per pound of body weight per day, administered by intravenous, subcutaneous, or intramuscular injection. In the treatment of severe foot rot and advanced cases of other indicated diseases, a dosage level of 5 milligrams per pound of body weight per day is recommended. Treatment should be continued 24 to 48 hours following remission of disease signs, however, not to exceed a total of four consecutive days. Consult your veterinarian if improvement is not noted within 24 to 48 hours of the beginning of treatment. Intramuscular administration is not recommended according to Beef Quality Assurance Guidelines.

Subcutaneous, Intramuscular, Intravenous

Bio-Mycin® 200

Cattle (beef and dairy)

A single dosage of 9 milligrams per pound of body weight administered intramuscularly or subcutaneously. Intramuscular administration is not recommended according to Beef Quality Assurance Guidelines.

Subcutaneous, Intramuscular, Intravenous

Bio-Mycin® 200

Beef Cattle, Non-lactating Dairy Cattle, and Calves including Pre-ruminating (Veal) Calves

3 to 5 milligrams per pound of body weight per day. For treatment of severe foot-rot and advanced cases of other indicated diseases, 5 milligrams per pound of body weight per day. Administer intramuscularly, subcutaneously, or intravenously. Treatment should be continued 24 to 48 hours following remission of disease signs, however, not to exceed a total of four consecutive days.

Intravenous, Subcutaneous, Intramuscular

Noromycin® 300 LA

Beef Cattle, Non-lactating Dairy Cattle, and Calves including Pre-ruminating (Veal) Calves

9 to 13.6 milligrams per pound of body weight. Administer once intramuscularly or subcutaneously.

Intravenous, Subcutaneous, Intramuscular

Noromycin® 300 LA

Cattle (calves, beef, and non lactating dairy)

10 milligrams per pound of body weight

Oral, Immersion

Prepare a fresh solution daily. Administer up to 14 days. Do not use for more than 14 consecutive days. Use as sole source of oxytetracycline. Do not administer this product with milk or milk replacers. Administer 1 hour before or 2 hours after feeding milk or milk replacers. Withdraw 5 days prior to slaughter. A milk discard period has not been established for this product in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older.

TERRAMYCIN-343®

0.5 to 2.0 grams per head per day in feed. Feed 3 to 5 days before and after arrival in feedlots.

Oral

Pennox 50®

Administered topically to the eye 2-4 times daily.

Ophthalmic

Terramycin®

0.5 to 2.0 g/head/day

Oral

Feed 3 to 5 days before and after arrival in feedlots. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100

Cattle (beef and non-lactating dairy: growing cattle over 400 pounds)

75 milligrams per head per day.

Oral

Feed continuously.

TM-50®

Cattle (calves including veal calves, beef, and non-lactating dairy)

10 milligrams per pound of body weight daily.

Oral

Feed continuously for 7 to 14 days. In milk replacer or starter feed. Withdraw 0 days before slaughter. When used in milk replacers, the treatment claim (10 mg/lb) is limited to bacterial enteritis caused by E. coli only.

TM-50®

Cattle (calves including veal calves, beef, and non-lactating dairy)

0.5 - 2.0 grams per head per day in feed.

Oral

Feed 3 to 5 days before and after arrival in feedlots.

TM-50®

Cattle (beef and dairy calves)

Orally administer 2 tablets per 100 lb of body weight every 12 hours (10 mg/lb of body weight daily in divided doses) for up to 4 consecutive days. Dosage should continue until the animal returns to normal and for 24-48 hours after symptoms have subsided. Treatment should not exceed 4 consecutive days.

Oral

Terramycin® Scours Tablets

Cattle (beef and non-lactating dairy, beef and dairy calves)

3 to 5 milligrams of oxytetracycline per pound of body weight per day (6 to 10 mL per 100 pounds of body weight) by intramuscular injection. For leptospirosis, severe foot rot and severe forms of the indicated diseases, 5 milligrams per pound of body weight per day. Treatment should be continued 24 to 48 hours following remission of disease symptoms, not to exceed a total of 4 consecutive days.

Intramuscular

Oxyject®

Cattle (heifers fed in confinement for slaughter)

Feed 0.25 to 2.0 g/ton melengestrol acetate to heifers at a rate of 0.5 to 2.0 lb/hd/day as a top dress or mixed into a complete feed to provide 0.25 to 0.5 mg melengestrol acetate per head per day and 75 to 300 g/ton oxytetracycline to provide 75 mg oxytetracycline per head per day. Continue feeding throughout the time the heifers are being grown and finished for slaughter.

Oral

Not effective in steers and spayed heifers. Withdrawal periods of three to five days should be avoided to prevent the possibility that the heifers may come into estrus (heat) at the time of loading. Do not mix with oxytetracycline as a common liquid feed supplement. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

MGA® (liquid) and TM®

Cattle (heifers fed in confinement for slaughter)

Melengestrol acetate, 0.25 to 0.50 milligram per head per day, plus oxytetracycline, 75 milligrams per head per day.

Oral

Add at the rate of 0.5 to 2.0 pounds per head per day a medicated feed (liquid or dry) containing 0.125 to 1.0 milligram of melengestrol acetate per pound to a feed containing 6 to 10 grams of oxytetracycline per ton; or add at the rate of 0.5 to 2.0 pounds per head per day a dry medicated feed containing 0.125 to 1.0 milligram of melengestrol acetate plus 37.5 to 150 milligrams of oxytetracycline per pound to provide 0.25 to 0.5 milligram of melengestrol acetate and 75 milligrams of oxytetracycline per head per day. Liquid melengestrol acetate may not be mixed with oxytetracycline in a common liquid feed supplement.

MGA® (liquid) and TM®

Cattle (heifers in confinement fed for slaughter)

Feed 0.25 to 2.0 g/ton melengestrol acetate to heifers at a rate of 0.5 to 2.0 lb/hd/day as a top dress or mixed into a complete feed to provide 0.25 to 0.5 mg melengestrol acetate per head per day and 75 to 300 g/ton oxytetracycline to provide 75 mg oxytetracycline per head per day. Melengestrol acetate and oxytetracycline may be fed continuously throughout the time the heifers are being grown and finished for slaughter.

Oral

Not effective in steers and spayed heifers. Withdrawal periods of three to five days should be avoided to prevent thepossibility that the heifers may come into estrus (heat) at the time of loading.Do not mix with oxytetracycline as a common liquid feed supplement. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

MGA® and TM®

Cattle (beef, beef calves, nonlactating dairy, dairy calves)

Administer 3 to 5 milligrams of the oxytetracycline hydrochloride intramuscularly per pound of body weight per day. In severe forms of the indicated diseases, administer the equivalent of 5 milligrams of oxytetracycline hydrochloride per pound of body weight per day. Continue treatment 24 to 48 hours following remission of disease symptoms, not to exceed a total of 4 consecutive days. Reduce the volume administered per injection site according to age and body size. In calves weighing 100 pounds or less inject only 2 milliliters per site.

Intramuscular

If no improvement is noted within 24 to 48 hours, consult a veterinarian for diagnosis and therapy. In adult livestock, do not inject more than 10 milliliters at any one site. Rapid intravenous administration may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least5 minutes.

Oxytetracycline-50

Cattle (calves)

10 mg oxytetracycline per pound body weight per day in milk replacer or starter feed. Feed continuously for 7-14 days.

Oral

Pennox 100-MR®

Cattle (calves)

10 milligrams per pound of body weight daily. Feed continuously for 7 to 14 days.

Oral

Terramycin® 100MR

Cattle (calves)

10 milligrams per pound of body weight daily.

Oral

Feed continuously for 7 to 14 days in milk replacer or starter feed. Zero-day withdrawal time.

Terramycin® 10

Calves, Beef Cattle, and Non-Lactating Dairy Cattle

75 milligrams per head per day.

Oral

Feed continuously.

Terramycin® 200

Calves, Beef Cattle, and Non-Lactating Dairy Cattle

10 mg/lb of body weight daily

Oral

Feed continuously for 7-14 days

Terramycin® 200

Calves, Beef Cattle, and Non-Lactating Dairy Cattle

10 mg/lb of body weight

Oral

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100D

Calves, Beef Cattle, and Non-Lactating Dairy Cattle

0.5-2.0 g/head/day

Oral

Feed 3-5 days before and after arrival in feedlots.

Terramycin® 200

Cattle (beef,dairy excluding lactating animals, and calves, including preruminating veal calves)

9 milligrams per pound of body weight intramuscularly or subcutaneously as a single dose.

Subcutaneous, Intramuscular, Intravenous

Administer intramuscularly or intravenously. Exceeding the highest recommended level of drug per pound of bodyweight per day, administering more than the recommended number of treatments, and/or exceeding 10 mL intramuscularly or subcutaneously per injection site may result in antibiotic residues beyond the withdrawal time. Rapid intravenous administration in cattle may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes. Discontinue treatment at least 28 days prior to slaughter. Not for use in lactating dairy animals. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Geomycin 200

Cattle (beef,dairy excluding lactating animals, and calves, including preruminating veal calves)

3 to 5 milligrams of oxytetracycline per pound of body weight per day.

Subcutaneous, Intramuscular, Intravenous

Administer intramuscularly, subcutaneously, or intravenously. Exceeding the highest recommended level of drug per pound of bodyweight per day, administering more than the recommended number of treatments, and/or exceeding 10 mL intramuscularly or subcutaneously per injection site may result in antibiotic residues beyond the withdrawal time. Rapid intravenous administration in cattle may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes. Discontinue treatment at least 28 days prior to slaughter. Not for use in lactating dairy animals. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Geomycin 200

Cattle (beef,dairy excluding lactating animals, and calves, including preruminating veal calves)

5 milligrams per pound of body weight per day.

Subcutaneous, Intramuscular, Intravenous

Administer intramuscularly, subcutaneously, or intravenously. Exceeding the highest recommended level of drug per pound of bodyweight per day, administering more than the recommended number of treatments, and/or exceeding 10 mL intramuscularly or subcutaneously per injection site may result in antibiotic residues beyond the withdrawal time. Rapid intravenous administration in cattle may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes. Discontinue treatment at least 28 days prior to slaughter. Not for use in lactating dairy animals.

Geomycin 200

Beef cattle; dairy cattle; and calves, including preruminating (veal) calves

3 to 5 milligrams of oxytetracycline per pound of body weight per day, administered by intravenous, subcutaneous, or intramuscular injection. In the treatment of severe foot-rot and advanced cases of other indicated diseases, a dosage of 5 milligrams per pound of body weight per day is recommended. Treatment should be continued 24 to 48 hours following remission of disease signs, however, not to exceed a total of four consecutive days. Consult your veterinarian if improvement is not noted within 24 to 48 hours of the beginning of treatment.

Subcutaneous, Intravenous, Intramuscular

Oxytetracycline Injection 200

Beef cattle; dairy cattle; and calves, including preruminating (veal) calves

A single dosage of 9 milligrams oxytetracycline per pound of body weight administered intramuscularly or subcutaneously.

Subcutaneous, Intravenous, Intramuscular

Oxytetracycline Injection 200

Beef and Dairy Calves

Administer orally half a bolus (250 mg oxytetracycline hydrochloride) per 100 lb of body weight every 12 hours (5 mg/lb body weight in divided doses) for up to four consecutive days.

Oral

OXY 500 Calf Bolus

Beef and Dairy Calves

250 milligrams per 100 pounds of body weight every 12 hours (5 milligrams per pound of body weight daily in two doses) for up to four consecutive days.

Oral

Dosage should continue until the animal returns to normal and for 24 hours to 48 hours after symptoms have subsided. Treatment should not exceed 4 consecutive days. Do not exceed 500 milligrams per 100 pounds of body weight every 12 hours (10 milligrams per pound daily). Discontinue treatment 7 days prior to slaughter. Not for use in lactating dairy cattle. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

OXY 1000 Calf Bolus

Beef and Dairy Calves

500 milligrams per 100 pound of body weight every 12 hours (10 milligrams per pound of body weight daily in two doses).

Oral

Dosage should continue until the animal returns to normal and for 24 hours to 48 hours after symptoms have subsided. Treatment should not exceed 4 consecutive days. Do not exceed 500 milligrams per 100 pounds of body weight every 12 hours (10 milligrams per pound daily). Discontinue treatment 7 days prior to slaughter. Not for use in lactating dairy cattle. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

OXY 1000 Calf Bolus

Cattle (beef and nonlactating dairy, beef and dairy calves [excluding veal calves])

3 to 5 milligrams of oxytetracycline per pound of body weight per day (3 to 5 mL per 100 pounds of body weight) by intramuscular, subcutaneous, or intravenous injection. Treatment should be continued 24 to 48 hours following remission of disease symptoms, not to exceed a total of 4 consecutive days.

Intramuscular

OXYJECT® 100

Calves (Up to 250 Lbs)

10 mg/lb of body weight daily

Oral

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100

Calves (Up to 250 Lbs)

10 mg/lb BW

Oral

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

Growing Cattle (Over 400 Lbs)

75 mg/head/day

Oral

Feed continuously. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100

Calves, Beef Cattle, and Non-Lactating Dairy

10 mg/lb body weight (BW)

Oral

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100

Calves (up to 250 Lbs)

In Milk Replacer: 10 mg/lb of body weight daily

Oral

Feed continuously for 7-14 days If symptoms persist after using for 2 or 3 days, consult a veterinarian. Treatment should continue 24 to 48 hours beyond remission of disease symptoms.

Neo-Terramycin® 50/50D

Calves (up to 250 Lbs)

10 mg/lb of body weight daily

Oral

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100D

Growing cattle (over 400 lb)

75 mg/head/day

Oral

Feed continuously. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

Calves, Beef Cattle, and Non-lactating Dairy Cattle

10 mg/lb of body weight daily

Oral

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

Cattle (Beef and Non-Lactating Dairy)

3 to 5 milligrams per pound of body weight daily, 5 milligrams per pound for anaplasmosis, severe foot rot, and severe forms of other diseases. Administer by intravenous injection.

Intravenous

Treatment should be continued 24 to 48 hours following remission of disease symptoms, but not to exceed a total of 4 consecutive days. If no improvement occurs within 24 to 48 hours, reevaluate diagnosis and therapy. Discontinue use at least 19 days prior to slaughter. This drug product is not approved for use in female dairy cattle 20months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows.

Biocyl-50

Cattle (Beef, Non-Lactating Dairy, Calves, Yearlings)

Administer once as an intramuscular or subcutaneous injection of 1 mL per 22 pounds (lb) body weight (BW) (13.6 mg oxytetracycline and 0.9 mg flunixin per lb BW) where retreatment of calves and yearlings for bacterial pneumonia is impractical due to husbandry conditions, such as cattle on range, or where their repeated restraint is inadvisable

Intramuscular, Subcutaneous

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intramuscular or subcutaneous use in beef and non-lactating dairy cattle, calves and yearlings. Not for use in female dairy cattle 20 months of age or older, including dry dairy cows, bulls intended for breeding, and calves intended to be processed for veal. Do not use in animals showing hypersensitivity to either flunixin meglumine or oxytetracycline.

Hexasol® Injection

Cattle (calves up to 250 lbs)

10 mg/lb body weight/day

Oral

Feed continuously for 7 to 14 days; in milk replacers or starter feed. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in pre-ruminating calves. Do not use in calves to be processed for veal.

Neo-Oxy 100/100 MR®

Growing cattle (over 400 lbs)

75 mg/head/day

Oral

Feed continuously.

Neo-Oxy 100/100 MR®

Cattle (calves and beef and nonlactating dairy cattle)

10 mg/lb body weight/day

Oral

Feed continuously for 7-14 days in feed or milk replacers. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. A withdrawal period has not been established for use in pre-ruminating calves. Do not use in calves to be processed for veal. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. Withdraw 5 days before slaughter.

Neo-Oxy 100/100 MR®

Cattle (calves, beef, nonlactating dairy)

10 milligrams per pound body weight daily in feed. Feed continuously for 7 to 14 days.

Oral

Pennox 50®

Cattle (growing, over 400 pounds body weight)

75 milligrams per head per day in feed. Feed continuously.

Oral

Pennox 100 Hi-Flo®

Cattle (growing, over 400 pounds body weight)

75 milligrams per head per day in feed.

Oral

Pennox 50®

Cattle (beef, dairy, and calves including preruminating (veal) calves)

3 to 5 milligrams of oxytetracycline per pound of body weight per day, administered by subcutaneous or intravenous injection. In the treatment of severe foot rot and advanced cases of other indicated diseases, a dosage level of 5 milligrams per pound of body weight per day is recommended. Treatment should be continued 24 to 48 hours following remission of disease signs, however, not to exceed a total of four consecutive days. Consult your veterinarian if improvement is not noted within 24 to 48 hours of the beginning of treatment.

Intramuscular, Intravenous, Subcutaneous

Tetroxy®-LA

Cattle (beef, dairy, and calves including preruminating (veal) calves)

A single dosage of 9 milligrams per pound of body weight administered by subcutaneous injection.

Intramuscular, Intravenous, Subcutaneous

Tetroxy®-LA

3 to 5 milligrams of oxytetracycline per pound of body weight per day administered by intramuscular injection. Treatment should be continued 24 to 48 hours following remission of disease signs, however, not to exceed a total of four consecutive days. Consult your veterinarian if improvement is not noted within 24 to 48 hours of the beginning of treatment.

Intravenous, Intramuscular

Oxytetracycline Injection

3 to 5 milligrams per pound of body weight per day. Administer intramuscularly. Treatment should be continued 24 to 48 hours following remission of disease signs, however, not to exceed a total of four consecutive days.

Intravenous, Subcutaneous, Intramuscular

Noromycin® 300 LA

10 to 25 grams carbadox and approximately 400 grams of chlortetracycline (varying with body weight and feed consumption to provide 10 milligrams of chlortetracycline per pound of body weight daily).

Oral

Feed continuously as the sole ration for 7 to 14 days. Not for use in pregnant swine or swine intended for breeding purposes. Do not mix in feeds containing bentonite. Do not feed to swine within 42 days of slaughter.

Mecadox® and Terramycin®

3 to 5 milligrams of oxytetracycline per pound of body weight per day (6 to 10 mL per 100 pounds of body weight) by intramuscular injection.

Intramuscular, Intravenous

Bio-Mycin®

Administer by intramuscular injection at 3 to 5 milligrams of oxytetracycline per pound of body weight per day to swine.

Intravenous, Intramuscular, Subcutaneous

Treatment of all diseases should be instituted early. Treatment should continue for 24 to 48 hours beyond the remission of disease symptoms, but not exceed a total of 4 consecutive days. If no improvement is noted within 24 to 48 hours, diagnosis and therapy should be reevaluated. When injecting intramuscularly in adult livestock, do not inject more than 10 milliliters at any one site. The volume administered per injection site should be reduced according to age and body size so that 1 or 2 milliliters are injected in smaller animals such as young pigs. Treatment must be discontinued at least 22 days prior to slaughter for swine. When administered intramuscularly to animals within 30 days of slaughter, muscle discoloration may necessitate trimming of the injection site(s) and surrounding tissues during the dressing procedure.

Liquamycin® Injectable

3 to 5 milligrams of oxytetracycline per pound of body weight per day by intramuscular or intravenous injection.

Intramuscular

OXYJECT® 100

A single dosage of 9 milligrams of oxytetracycline per pound of body weight administered intramuscularly.

Subcutaneous, Intravenous, Intramuscular

Oxytetracycline Injection 200

Three to 5 milligrams of oxytetracycline per pound of body weight per day. Administer intramuscularly.

Intramuscular

Do not inject more than 5 milliliters per site. Do not use for more than 4 consecutive days. Discontinue treatment at least 26 days before slaughter.

Bio-Mycin C

10 milligrams per pound body weight daily in feed. Feed continuously for 7 to 14 days.

Oral

Pennox 50®

Administer 10 milligrams per pound of body weight daily in drinking water.

Oral

Prepare a fresh solution daily. Use as the sole source of oxytetracycline. Administer up to 5 days; do not use for more than 5 consecutive days. Use as sole source of drinking water. Do not mix this product directly with milk or milk replacers. Administer one hour before or two hours after feeding milk or milk replacers. Withdraw zero days prior to slaughter. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

AGRIMYCIN®-343

9 milligrams per pound of body weight. Administer once intramuscularly.

Intravenous, Subcutaneous, Intramuscular

Noromycin® 300 LA

3 to 5 milligrams of oxytetracycline per pound of body weight per day.

Subcutaneous, Intramuscular, Intravenous

Administer intramuscularly. Do not inject more than 5 mL per site in adult swine. Discontinue treatment at least 28 days prior to slaughter.

Geomycin 200

10 milligrams per pound of body weight in drinking water.

Oral, Immersion

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Prepare a fresh solution daily. Administer up to 14 days. Do not use for more than 14 consecutive days. Use as a sole source of oxytetracycline. Zero-day slaughter withdrawal in swine.

Tetroxy® 343

9 milligrams per pound of body weight as a single dosage.

Subcutaneous, Intramuscular, Intravenous

Administer intramuscularly. Do not inject more than 5 mL per site in adult swine. Discontinue treatment at least 28 days prior to slaughter.

Geomycin 200

10 milligrams per pound of body weight daily.

Oral

Feed continuously for 7 to 14 days.

TM-50® D

10 mg/lb of body weight daily.

Oral

Feed continuously for 7-14 days. 5-day withdrawal before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 100/100

10 mg/lb BW

Oral

Feed continuously for 7 to 14 days. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

Swine (breeding stock)

Administer 10 milligrams per pound of body weight daily in drinking water.

Oral

Prepare a fresh solution daily. Use as the sole source of oxytetracycline. Administer up to 5 days; do not use for more than 5 consecutive days. Use as sole source of drinking water. Do not mix this product directly with milk or milk replacers. Administer one hour before or two hours after feeding milk or milk replacers. Withdraw zero days prior to slaughter. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

AGRIMYCIN®-343

Swine (breeding stock)

10 milligrams per pound of body weight.

Oral, Immersion

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Prepare a fresh solution daily. Administer up to 14 days. Do not use for more than 14 consecutive days. Use as a sole source of oxytetracycline. Zero–day slaughter withdrawal in swine.

Tetroxy® 343

Sows

3 mg of oxytetracycline per lb of body weight administered once by intramuscular injection approximately 8 hours before farrowing or immediately after completion of farrowing.

Intravenous, Intramuscular

Oxytetracycline Injection

Sows

3 milligrams per pound of body weight intramuscularly once.

Subcutaneous, Intramuscular, Intravenous

Administer intramuscularly. Do not inject more than 5 mL per site in adult swine. Discontinue treatment at least 28 days prior to slaughter.

Geomycin 200

Swine (sows)

3 mg of oxytetracycline per lb of body weight administered once by intramuscular injection approximately 8 hours before farrowing or immediately after completion of farrowing.

Intravenous, Subcutaneous, Intramuscular

AGRIMYCIN® 200

Swine (sows)

3 milligrams of oxytetracycline per pound of body weight, approximately 8 hours before farrowing or immediately after completion of farrowing. Administer intramuscularly.

Intramuscular

Do not inject more than 5 milliliters per site. Do not use for more than 4 consecutive days. Discontinue treatment at least 26 days before slaughter.

Bio-Mycin C

Swine (Sows)

3 milligrams of oxytetracycline per pound of body weight (6 mL per 100 lbs. body weight), by intramuscular injection, approximately 8 hours before farrowing or immediately after completion of farrowing.

Intramuscular, Intravenous

Bio-Mycin®

Swine (Sows)

3 milligrams per pound of body weight. Administer once intramuscularly approximately 8 hours before farrowing or immediately after completion of farrowing.

Intravenous, Subcutaneous, Intramuscular

Noromycin® 300 LA

Breeding Swine

10 milligrams per pound of body weight.

Oral, Immersion

Prepare a fresh solution daily. Administer up to 14 days. Do not use for more than 14 consecutive days. Use as a sole source of oxytetracycline. Zero–day slaughter withdrawal in swine.

TERRAMYCIN® Soluble Powder Concentrate

Breeding Swine

10 mg/lb of body weight daily.

Oral

Feed continuously for not more than 14 days

Terramycin® 200 Granular

Breeding Swine

10 mg/lb BW

Oral

Feed continuously for not more than 14 days. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

Swine (sows about to farrow or just farrowed).

Administered to sows at 3 milligrams of oxytetracycline per pound of body weight approximately 8 hours before farrowing or immediately after farrowing. Administer intramuscularly.

Intravenous, Intramuscular, Subcutaneous

Treatment of all diseases should be instituted early. Treatment should continue for 24 to 48 hours beyond the remission of disease symptoms, but not exceed a total of 4 consecutive days. If no improvement is noted within 24 to 48 hours, diagnosis and therapy should be reevaluated. When injecting intramuscularly in adult livestock, do not inject more than 10 milliliters at any one site. The volume administered per injection site should be reduced according to age and body size so that 1 or 2 milliliters are injected in smaller animals such as young pigs. Treatment must be discontinued at least 22 days prior to slaughter for swine. When administered intramuscularly to animals within 30 days of slaughter, muscle discoloration may necessitate trimming of the injection site(s) and surrounding tissues during the dressing procedure.

Liquamycin® Injectable

Swine (Breeding)

10 milligrams per pound of body weight daily.

Oral

Feed continuously for not more than 14 days.

TM-50® D

Swine (breeding)

10 milligrams per pound body weight daily in feed. Feed continuously for 7 to 14 days.

Oral

Pennox 50®

Swine (breeding)

10 milligrams per pound of body weight daily.

Oral

Feed continuously for not more than 14 days.

TM-100®

Swine (breeding)

10 mg/lb/body weight/day

Oral

Feed continuously for not more than 14 days; withdraw 5 days before slaughter.

Neo-Oxy 100/100 MR®

Swine (sows with litters or about to farrow)

3 milligrams of oxytetracycline per pound of body weight, administered once, approximately 8 hours before farrowing or immediately after completion of farrowing. Administer intramuscularly.

Intramuscular

Do not inject more than 5 milliliters per site in adult swine, reducing the volume according to age and body size to 1 to 2 milliliters in young pigs. Discontinue treatment at least 22 days prior to slaughter.

Liquamycin® 100

Breeding swine

10 mg/lb/body weight/day

Oral

Feed continuously for not more than 14 days; withdraw 5 days before slaughter.

Neo-Oxy 50/50®

1.0 gram of oxytetracycline as oxytetracycline hydrochloride and 1.0 gram carbomycin as carbomycin base per gallon of drinking water.

Oral

Administer for not more than 5 days. Not for use in chickens producing eggs for human consumption. Withdraw 24 hours before slaughter.

MAGNA-TERRAMYCIN® Soluble Powder

Administer 200 to 400 milligrams of powder per gallon of drinking water.

Oral

Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption. Use as the sole source of oxytetracycline. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

AGRIMYCIN®-343

100 to 200 grams per ton of feed. Feed continuously for 7-14 days.

Oral

Pennox 50®

200 to 400 milligrams per gallon of drinking water.

Oral, Immersion

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption.

Tetroxy® 343

100 to 200 grams per ton of feed.

Oral

Feed continuously for 7 to 14 days. At 500 g/ton level,withdraw 24 hours before slaughter. Zero-day withdrawal period for lower use levels. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Do not administer to chickens producing eggs for human consumption.

Terramycin® 10

500 grams per ton of feed.

Oral

Feed continuously for 5 days. Do not administer to chickens producing eggs for human consumption. Withdraw 24 hours before slaughter. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues.

TM-50®

100 to 200 g/ton

Oral

Feed continuously for 7-14 days; do not feed to chickens producing eggs for human consumption; in low calcium feed, withdraw 3 days before slaughter.

Neo-Oxy 100/100 MR®

100-200 g/ton.

Oral

Feed continuously for 7-14 days. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

500 g/ton.

Oral

Feed continuously for 5 days. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

400 g/ton

Oral

Feed continuously for 7-14 days

Terramycin® 200

Chickens (broilers)

500 grams oxytetracycline and 40 to 60 grams salinomycin sodium per ton of feed of Type C medicated feed.

Oral

Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. Feed for 5 days as sole ration. Treat at first clinical signs of disease. Do not feed to laying chickens. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Withdraw 24 hours prior to slaughter. Do not use in feeds containing pellet binders. May be fatal if accidentally fed to adult turkeys or to horses.

Sacox® / Terramycin®

Chickens (broilers)

30 grams robenidine hydrochloride and 400 grams oxytetracycline per ton of Type C medicated feed.

Oral

Feed continuously for 7 to 14 days. Do not feed to chickens producing eggs for human consumption. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Withdraw 5 days before slaughter. Feed must be used within 50 days from date of manufacture. Do not use in feeds containing bentonite.

TM® plus Robenz®

Chickens (broilers)

90 or 110 grams monensin and 200 grams oxytetracycline per ton of Type C medicated feed.

Oral

Feed continuously as sole ration. Withdraw 72 hours before slaughter. Do not feed to laying chickens. Do not feed to chickens over 16 weeks of age. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Do not allow horses other equines, mature turkeys, or guinea fowl access to feed containing monensin. Ingestion of monensin by horses andguinea fowl has been fatal. In the absence of coccidiosis in broiler chickens, use of monensin with no withdrawal period may limit feed intake, resulting in reduced weight gain. Not for replacement chickens intended to become breeding chickens.

Coban™/TM®

Chickens (broilers)

500 grams per ton of feed.

Oral

Feed for 5 days as sole ration. Treat at first clinical signs of disease. Do not feed to laying hens. Withdraw 24 hours prior to slaughter.

Terramycin® Premix

Chickens (broilers and breeding chickens)

Administered subcutaneously to chickens 1 day to 2 weeks of age at 6.25 milligrams of oxytetracycline per bird per day diluted with 1 part of the drug to 3 parts of sterile water; to chickens 2 to 4 weeks of age using the same diluted product at 12.5 milligrams of oxytetracycline per bird; to chickens 4 to 8 weeks of age without dilution at 25 milligrams of oxytetracycline per bird; to chickens 8 weeks of age (broilers and light pullets) at 50 milligrams of oxytetracycline per bird; to adult chickens at 100 milligrams of oxytetracycline per bird.

Intravenous, Intramuscular, Subcutaneous

Treatment of all diseases should be instituted early. Treatment should continue for 24 to 48 hours beyond the remission of disease symptoms, but not exceed a total of 4 consecutive days. If no improvement is noted within 24 to 48 hours, diagnosis and therapy should be reevaluated. Treatment must be discontinued at least 5 days prior to slaughter for chickens. Do not administer to laying hens unless the eggs are used for hatching only.

Liquamycin® Injectable

Chickens (broiler)

500 grams oxytetracycline and 40 to 60 grams salinomycin sodium per ton of feed of Type C medicated feed.

Oral

Feed for 5 days as sole ration. Treat at first clinical signs of disease. Do not feed to laying chickens. Do not use in low-calcium feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Withdraw 24 hours before to slaughter. Do not use in feeds containing pellet binders. May be fatal if accidentally fed to adult turkeys or to horses.

TM® plus Bio-Cox®

Broiler chickens

500 grams per ton of feed. Feed continuously for 5 days.

Oral

Pennox 50®

Administered subcutaneously to turkeys 1 day to 2 weeks of age and 2 to 4 weeks of age at the same dosage as chickens; to turkeys 4 to 6 weeks of age at 50 milligrams of oxytetracycline as the undiluted product per bird; to turkeys 6 to 9 weeks of age at 100 milligrams of oxytetracycline per bird; to turkeys 9 to 12 weeks of age at 150 milligrams of oxytetracycline per bird; to turkeys 12 weeks of age and older at 200 milligrams of oxytetracycline per bird. In light turkey breeds, no more than 25 milligrams per pound of body weight is administered. For the treatment of infectious sinusitis in turkeys, 1/4 to 1/2 milliliter of the drug is injected directly into each swollen sinus depending upon the age of the bird and the severity of the condition. At the time that the sinuses are treated, the drug should also be administered subcutaneously to the birds according to the dosage schedule stated above for chickens and turkeys. If refilling of the sinuses occurs, the treatment may be repeated in 5 to 7 days.

Intravenous, Intramuscular, Subcutaneous

Treatment of all diseases should be instituted early. Treatment should continue for 24 to 48 hours beyond the remission of disease symptoms, but not exceed a total of 4 consecutive days. If no improvement is noted within 24 to 48 hours, diagnosis and therapy should be reevaluated. Treatment must be discontinued at least 5 days prior to slaughter for turkeys. Do not administer to laying hens unless the eggs are used for hatching only.

Liquamycin® Injectable

25 milligrams per pound body weight daily in feed. Feed continuously for 7 to 14 days.

Oral

Pennox 100 Hi-Flo®

Administer 200 to 400 milligrams of powder per gallon of drinking water.

Oral

Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption. Use as the sole source of oxytetracycline. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

AGRIMYCIN®-343

100 grams per ton of feed. Feed continuously for 7 to 14 days.

Oral

Pennox 50®

200 to 400 milligrams per gallon of drinking water.

Oral

Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption.

Oxytetracycline Hydrochloride Soluble Powder

25 mg/lb of body weight per day in drinking water.

Oral

Administer for 7 to 14 days; do not slaughter for food within 4 days of treatment; not for use in turkeys producing eggs for human consumption; prepare a fresh solution daily; use as the sole source of tetracycline.

OXY WS™

25 milligrams per pound of body weight daily.

Oral

Feed continuously for 7 to 14 days. Withdraw 5 days before slaughter. Do not administer to turkeys producing eggs for human consumption.

Terramycin® 10

25 mg/lb of body weight daily

Oral

Feed continuously for 7-14 days

Terramycin® 200

100 grams per ton of feed.

Oral

Feed continuously for 7 to 14 days. Do not administer to turkeys producing eggs for human consumption.

TM-50®

25 mg/lb BW

Oral

Feed continuously for 7 to 14 days. Withdraw 5 days before slaughter. Do not feed to turkeys producing eggs for human consumption. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

200 g/ton

Oral

Feed continuously for 7-14 days

Terramycin® 200

100 g/ton

Oral

Feed continuously for 7-14 days

Terramycin® 200

Turkeys (growing)

Administer 25 milligrams per pound of body weight in drinking water.

Oral

Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption. Use as the sole source of oxytetracycline. Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

AGRIMYCIN®-343

Turkeys (growing)

25 milligrams per pound of body weight.

Oral

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of oxytetracycline. Use as a sole source of drinking water. Do not use in birds producing eggs for human consumption. Withdraw 5 days prior to slaughter.

Tetroxy® 25

Turkeys (growing)

100 grams per ton of feed.

Oral

Feed continuously for 7 to 14 days. Do not administer to turkeys producing eggs for human consumption.

TM-50® D

Turkeys (Growing)

25 milligrams per pound of body weight daily

Oral, Immersion

Prepare a fresh solution daily. Administer 7 to 14 days. Not to be used for more than 14 consecutive days. Use as sole source of drinking water. Do not use in birds producing eggs for human consumption.

TERRAMYCIN-343®

200 mg/oz (Dusting) – Apply 1 oz (200 mg oxytetracycline) of dusting Type C medicated feed per colony every 4 to 5 days for a total of 3 applications. Apply the dust on the outer parts or ends of the frames. 200 mg/5 lb (Syrup) – Feed 5 lb of syrup (200 mg oxytetracycline) per colony every 4 to 5 days for a total of 3 applications. Bulk feed the syrup using feeder pails, or division board feeders, or by filling the combs. Prepare fresh ssyrup for each application. 800 mg/patty (Extender Patty) – Place one patty per colony on the top bars fo the brood nest frames in a single application.

Oral

Terramycin® 100MR

200 milligrams per colony, administered via either an 1:1 sugar syrup (equal parts of sugar and water weight to weight) or dusting with a powdered sugar mixture.

Oral

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. The drug is administered in 3 applications of sugar syrup or 3 dustings at 4- to 5- days intervals. The drug should be fed early in the spring or fall and consumed by the bees before main honey flow begins to avoid contamination of production honey. Remove at least 6 weeks prior to main honey flow. Dusting of uncapped brood cells has been reported to cause death of larval honey bees. Do not dust uncapped brood cells.

Tetroxy® 25

200 milligrams / oz dusting of Type C medicated feed per colony every 4 to 5 days for a total of 3 applications

Oral

Pennox 50®

200 milligrams / 5 lb syrup per colony every 4 to 5 days for a total of 3 applications

Oral

Pennox 100 Hi-Flo®

200 milligrams / patty per colony as a single application

Oral

Pennox 200 Hi-Flo®

200 milligrams per colony.

Oral

Remove at least 6 weeks prior to main honey flow.

TM-50®

Honey Bees

200 mg/oz (Dusting), 200 mg/5 lb (Syrup), 800 mg/patty (Extender Patty)”. The Withdrawal Periods and Residue Warnings for honey bees should be changed to: “Remove at least 6 weeks prior to main honey flow. Type C medicated feeds should be fed in the spring or fall and consumed by the bees before main honey flow begins to avoid contamination of production honey. Honey stored during medication periods in combs for surplus honey should be removed following final medication of the bee colony and must not be used for human food.

Oral

Remove at least 6 weeks prior to main honey flow.

TM-50® D

Honey Bees

200 milligrams per colony, administered via either a 1:1 sugar syrup (equal parts of sugar and water weight to weight) or dusting with a powdered sugar mixture.

Immersion, Oral

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. The drug is administered in 3 applications of sugar syrup or 3 dustings at 4- to 5- days intervals. The drug should be fed early in the spring or fall and consumed by the bees before main honey flow begins to avoid contamination of production honey. Remove at least 6 weeks prior to main honey flow. Dusting of uncapped brood cells has been reported to cause death of larval honey bees. Do not dust uncapped brood cells.

Pennox 343®

Finfish fry and fingerlings

Immerse fish in a solution containing 200 to 700 mg oxytetracycline hydrochloride (buffered) per liter of water for 2 to 6 hours.

Oral, Immersion

Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

Tetroxy® 343

Finfish

Immerse fish in a solution containing 200 to 700 mg oxytetracycline hydrochloride (buffered) per liter of water for 2 to 6 hours.

Oral, Immersion

Solution should be tested on a small number of fish before full-scale use. Do not discharge marking immersion water containing oxytetracycline into surface waters. Oxytetracycline HCl will acidify the water. The pH should be maintained at an acceptable level for fish by the addition of a buffer. Monitor water quality and temperature.

TERRAMYCIN-343®

Pacific Salmon

250 milligrams of Oxytetracycline per kilogram of fish per day (11.35 grams per 100 pounds of fish per day) in fish feed.

Oral

For salmon not over 30 grams body weight. Administer as sole ration for 4 consecutive days.

Terramycin® 100 for Fish

Freshwater-reared salmonids

2.5 to 3.75 grams Oxytetracycline per 100 pounds of fish per day in fish feed.

Oral

Administer in mixed ration for 10 days.

Terramycin® 100 for Fish

Freshwater-reared salmonids

3.75 g oxytetracycline per 100 lb of fish per day for 10 days.

Oral

Administer in mixed ration for 10 days.

Terramycin® 100 for Fish

Catfish

3.75 g oxytetracycline per 100 lb of fish per day for 10 days. Administer in mixed ration for 10 days. Do not administer when water temperature is below 16.7 degrees C (62 degrees F).

Oral

Terramycin® 100 for Fish

Catfish

2.5 to 3.75 grams Oxytetracycline per 100 pounds of fish per day in fish feed.

Oral

Administer in mixed ration for 10 days. Do not administer when water temperature is below 16.7 degrees C (62 degrees F).

Terramycin® 100 for Fish

Freshwater-reared salmonids weighing up to 55 grams

3.75 g oxytetracycline per 100 lb of fish per day for 10 days. Feed for 10 days.

Oral

Terramycin® 100 for Fish

10 milligrams per pound of body weight daily in feed. Feed continuously for 7 to 14 days.

Oral

Pennox 50®

10 milligrams per pound of body weight in drinking water.

Oral, Immersion

Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Prepare a fresh solution daily. Administer up to 14 days. Do not use for more than 14 consecutive days. Use as a sole source of oxytetracycline. Withdraw 5 days prior to slaughter.

Tetroxy® 343

Administered topically to the eye 2-4 times daily.

Ophthalmic

Terramycin®

10 milligrams per pound of body weight daily.

Oral

Feed continuously for 7 to 14 days. Withdraw 5 days before slaughter.

TM-50®

10 mg/lb of body weight daily

Oral

Feed continuously for 7-14 days

Terramycin® 200

10 mg/lb of body weight

Oral

Feed continuously for 7 to 14 days. Treatment should continue 24 to 48 hours beyond remission of disease symptoms. Withdraw 5 days before slaughter. Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

Neo-Terramycin® 50/50

A small quantity should be sprayed on the affected surface by holding the container about 6 inches from the area to be treated and pressing the nozzle for 1 or 2 seconds. Only sufficient spray to coat the skin thinly is necessary. The application of small amounts at frequent intervals will give best results. Before treating animals with long or matted hair, it may be necessary to clip the affected area or spread the hairs to allow the medication to contact the skin surface. Relief may be noted following the first or second treatment; however, treatment should not be discontinued too soon after the initial favorable response has been obtained.

Topical

Keep away from eyes or other mucous membranes. Avoid inhaling. Use with adequate ventilation. In case of deep or puncture wounds or serious burns, consult a veterinarian.

Liqua-Cortril Spray

The drug is administered intramuscularly at a recommended daily dosage to dogs at 5 milligrams per pound of body weight administered in divided doses at 6 to 12 hour intervals. Therapy should be continued for at least 24 hours after all symptoms have subsided.

Intramuscular

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Aquachel 100 mg

The drug is administered orally to dogs at a dosage level of 25- 50 milligrams per pound of body weight per day in divided doses at 12-hour intervals.

Oral

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Terramycin® Vet Capsules

Administered topically to the eye 2-4 times daily.

Ophthalmic

Terramycin®

A small quantity should be sprayed on the affected surface by holding the container about 6 inches from the area to be treated and pressing the nozzle for 1 or 2 seconds. Only sufficient spray to coat the skin thinly is necessary. The application of small amounts at frequent intervals will give best results. Before treating animals with long or matted hair, it may be necessary to clip the affected area or spread the hairs to allow the medication to contact the skin surface. Relief may be noted following the first or second treatment; however, treatment should not be discontinued too soon after the initial favorable response has been obtained.

Topical

Keep away from eyes or other mucous membranes. Avoid inhaling. Use with adequate ventilation. In case of deep or puncture wounds or serious burns, consult a veterinarian.

Liqua-Cortril Spray

The drug is administered orally to cats at a dosage level of 25- 50 milligrams per pound of body weight per day in divided doses at 12-hour intervals.

Oral

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Terramycin® Vet Capsules

Administered topically to the eye 2-4 times daily.

Ophthalmic

Terramycin®

Lobster

1 gram Oxytetracycline per pound of medicated feed in fish feed.

Oral

Administer as sole ration for 5 consecutive days.

Terramycin® 100 for Fish

Lobsters

1 gram per pound medicated feed.

Oral

Administer as sole ration for 5 consecutive days. Withdraw medicated feed 30 days before harvesting lobsters.

TM-50®

Administered topically to the eye 2-4 times daily.

Ophthalmic

Terramycin®

Thoroughly mix the amount of this Type A Medicated Article according to the directions below withat least an equal amount by weight of feed ingredients prior to blending into a complete feed. Indications for Use Oxytetracycline and Neomycin Amount lb. of Neo-Terramycin 100/100 per ton CHICKENS Control of infectious synovitis caused by Mycoplasma synoviae; control of fowl cholera caused by Pasteurella multocida susceptible to oxytetracycline 100-200 g/ton Feed continuously for 7-14 days 1-2 Control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and E. coli susceptible to oxytetracycline 400 g/ton Feed continuously for 7-14 days 4 Reduction of mortality due to air sacculitis (air sac infection) caused by E. coli susceptible to oxytetracycline 500 g/ton Feed continuously for 5 days 5 WARNING: At 500 g/ton level, withdraw 24 hours before slaughter. Low calcium feeds at 500 g/ton, withdraw 3 days before slaughter. Zero-day withdrawal period for lower use levels. In low calcium feeds withdraw 3 days before slaughter. Do not administer to chickens producing eggs for human consumption. TURKEYS Control of hexamitiasis caused by Hexamita meleagridis susceptible to oxytetracycline 100 g/ton Feed continuously for 7-14 days 1 Control of infectious synovitis caused by Mycoplasma synoviae susceptible to oxytetracycline 200 g/ton Feed continuously for 7-14 days 2 Control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis) susceptible to oxytetracycline 25 mg/lb of body weight daily Feed continuously for 7-14 days 8.351 WARNING: At 200 g/ton use level or higher, withdraw 5 days before slaughter. Zero-day withdrawal period for lower use levels. Do not administer to turkeys producing eggs for human consumption. SWINE Treatment of bacterial enteritis caused by E. coli and Salmonella choleraesuis susceptible to oxytetracycline and treatment of bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin 10 mg/lb of body weight daily Feed continuously for 7-14 days 52 For breeding swine for control and treatment of Leptospirosis (reducing the incidence of abortion and shedding of leptospirae) caused by Leptospira pomona susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for not more than 14 days 52 WARNING: 5-day withdrawal before slaughter at 10 mg/lb dosage. CALVES, BEEF CATTLE, AND NONLACTATING DAIRY CATTLE For growing cattle (over 400 lb) for reduction of liver condemnation due to liver abscesses 75 mg/head/day Feed continuously 0.753 Prevention and treatment of the early stages of shipping fever complex 0.5-2.0 g/head/day Feed 3-5 days before and after arrival in feedlots 5-203 Treatment of bacterial enteritis caused by E. coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin 10 mg/lb of body weight daily Feed continuously for 7-14 days Treatment should continue 24 to 48 hours beyond remission of disease symptoms. 504 For calves (up to 250 lb) for treatment of bacterial enteritis caused by E. coli susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin 10 mg/lb of body weight daily Feed continuously for 7-14 days Treatment should continue 24 to 48 hours beyond remission of disease symptoms. 105 WARNING: A withdrawal period has not been established in preruminating calves; do not use in calves to be processed for veal. At the 0.5-2.0 g/head/day and 10 mg/lb levels: A milk discard time has not been established for use in lactating dairy cattle; do not use in female dairy cattle 20 months of age or older. At the 10 mg/lb level, withdraw 5 days before slaughter. Use of more than one product containing neomycin or failure to follow withdrawal times may result in illegal drug residues. SHEEP Treatment of bacterial enteritis caused by E. coli and bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin 10 mg/lb of body weight daily Feed continuously for 7-14 days Treatment should continue 24 to 48 hours beyond remission of disease symptoms. 126 WARNING: 5-day withdrawal before slaughter at 10 mg/lb dosage. 1If bird weighs 10 lb, consuming 0.6 lb of complete feed per day 2If pig weighs 100 lb, consuming 4 lb of complete feed per day 3Include in feed supplement based on consumption of 2 lb of supplement per head per day 4If animal weighs 500 lb, consuming 2 lb of supplement per head per day 5If calf weighs 100 lb, consuming 2 lb of complete starter feed per day 6If lamb weighs 60 lb, consuming 1 lb of supplement per head per day

ORAL

Neo-Terramycin® 100/100 (neomycin-oxytetracycline) TYPE A MEDICATED ARTICLE

1.Raise the vein. This is accomplished by tying the choke rope tightly around the neck close to the shoulder. The rope should be tied in such a way that it will not come loose and so that it can be untied quickly by pulling the loose end (See Fig. II). In thick-necked animals, a block of wood placed in the jugular groove between the rope and the hide will help considerably in applying the desired pressure at the right point. The vein is a soft flexible tube through which the blood flows back to the heart. Under ordinary conditions, it cannot be seen or felt with the fingers. When the flow of blood is blocked at the base of the neck by the choke rope, the vein becomes enlarged and rigid because of the back pressure. If the choke rope is sufficiently tight, the vein stands out and can be easily seen and felt in thin-necked animals. As a further check in identifying the vein, tap it with the fingers in front of the choke rope. Pulsations that can be seen or felt with the fingers in front of the point being tapped will confirm the fact that the vein is properly distended. It is impossible to put the needle into the vein unless it is distended. Experienced operators are able to raise the vein simply by hand pressure, but the use of a choke rope is more certain. 2.Inserting the needle. This involves three distinct steps. First, insert the needle through the hide. Second, insert the needle into the vein. This may require two or three attempts before the vein is entered. The vein has a tendency to roll away from the point of the needle, especially if the needle is not sharp. The vein can be steadied with the thumb and finger of one hand. With the other hand, the needle point is placed directly over the vein, slanting it so that its direction is along the length of the vein, either toward the head or toward the heart. Properly positioned this way, a quick thrust of the needle will be followed by a spurt of blood through the needle, which indicates that the vein has been entered. Third, once in the vein, the needle should be inserted along the length of the vein all the way to the hub, exercising caution to see that the needle does not penetrate the opposite side of the vein. Continuous steady flow of blood through the needle indicates that the needle is still in the vein. If blood does not flow continuously, the needle is out of the vein (or clogged) and another attempt must be made. If difficulty is encountered, it may be advisable to use the vein on the other side of the neck. 3.While the needle is being placed in proper position in the vein, an assistant should get the medication ready so that the injection can be started without delay after the vein has been entered. 4.Making the injection. With the needle in position as indicated by continuous flow of blood, release the choke rope by a quick pull on the free end. This is essential - the medication cannot flow into the vein while it is blocked. Immediately connect the syringe containing BIO-MYCIN 200 to the needle and slowly depress the plunger. If there is resistance to depression of the plunger, this indicates that the needle has slipped out of the vein (or is clogged) and the procedure will have to be repeated. Watch for any swelling under the skin near the needle, which would indicate that the medication is not going into the vein. Should this occur, it is best to try the vein on the opposite side of the neck. 5.Removing the needle. When injection is complete, remove needle with straight pull. Then apply pressure over area of injection momentarily to control any bleeding through needle puncture, using cotton soaked in alcohol or other suitable antiseptic.

INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS

Bio-Mycin® 200 (oxytetracycline injection)

Mixing and Use Directions Thoroughly mix the amount of this Type A medicated article according to the directions below with at least an equal amount by weight of feed formula ingredients prior to blending into a complete feed. Indications for Use Oxytetracycline Amount lb of Terramycin 100/ton CHICKENS Control of infectious synovitis caused by Mycoplasma synoviae; control of fowl cholera caused by Pasteurella multocida susceptible to oxytetracycline 100-200 g/ton Feed continuously for 7-14 days 1-2 Control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and Escherichia coli susceptible to oxytetracycline 400 g/ton Feed continuously for 7-14 days 4 Reduction of mortality due to air sacculitis (air sac infection) caused by Escherichia coli susceptible to oxytetracycline 500 g/ton Feed continuously for 5 days 5 WARNING: At 500 g/ton level, withdraw 24 hours before slaughter. Zero-day withdrawal period for lower use levels. Do not use in low-calcium feed containing less than 0.55 dietary calcium. Use in such may result in violative residues. Do not administer to chickens producing eggs for human consumption. TURKEYS Control of hexamitiasis caused by Hexamita meleagridis susceptible to oxytetracycline 100 g/ton Feed continuously for 7-14 days 1 Control of infectious synovitis caused by Mycoplasma synoviae susceptible to oxytetracycline 200 g/ton Feed continuously for 7-14 days 2 Control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis) susceptible to oxytetracycline 25 mg/lb of body weight daily Feed continuously for 7-14 days 8.31 WARNING: At 200 g/ton use level or higher, withdraw 5 days before slaughter. Zero-day withdrawal period for lower use levels. Do not administer to turkeys producing eggs for human consumption. SWINE Treatment of bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis susceptible to oxytetracycline and treatment of bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for 7-14 days 52 For breeding swine for control and treatment of Leptospirosis (reducing the incidence of abortion and shedding of leptospirae) caused by Leptospira pomona susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for not more than 14 days 52 CALVES, BEEF CATTLE, AND NONLACTATING DAIRY CATTLE For growing cattle (over 400 lb) for the reduction of the incidence of liver abscesses 75 mg/head/day Feed continuously 0.753 Prevention and treatment of the early stages of shipping fever complex (Feed 3-5 days before and after arrival in feedlots.) 0.5-2.0 g/head/day 5-203 Treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for 7-14 days 504 SHEEP Treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for 7-14 days 125 WARNING: 5-day withdrawal before slaughter. 1If bird weighs 10 lb, consuming 0.6 lb of complete feed per day 2Pig consuming 4 lb of complete feed per 100 lb body weight per day 3Include in feed supplement based on consumption of 2 lb of supplement per head per day 4If animal weighs 500 lb, consuming 2 lb of supplement per head per day 5If lamb weighs 60 lb, consuming 1 b of supplement per head per day RESTRICTED DRUG (CALIFORNIA) – USE ONLY AS DIRECTED NOT FOR HUMAN USE

ORAL

Terramycin® 100 (oxytetracycline) TYPE A MEDICATED ARTICLE

Mixing and Use Directions Thoroughly mix the amount of this Type A medicated article according to the directions below with at least an equal amount by weight of feed formula ingredients prior to blending into a complete feed. Indications for Use Oxytetracycline Amount lb of Terramycin 50/ton CHICKENS Control of infectious synovitis caused by Mycoplasma synoviae; control of fowl cholera caused by Pasteurella multocida susceptible to oxytetracycline 100-200 g/ton Feed continuously for 7-14 days 2-4 Control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasmagallisepticum and Escherichia coli susceptible to oxytetracycline 400 g/ton Feed continuously for 7-14 days 8 Reduction of mortality due to air sacculitis (air sac infection) caused by Escherichia coli susceptible to oxytetracycline 500 g/ton Feed continuously for 5 days 10 WARNING: At 500 g/ton level, withdraw 24 hours before slaughter. Zero-day withdrawal period for lower use levels. Do not use in feed containing less than 0.55% dietary calcium. Use in such feeds may result in violative residues. Do not administer to chickens producing eggs for human consumption. TURKEYS Control of hexamitiasis caused by Hexamitameleagridis susceptible to oxytetracycline 100 g/ton Feed continuously for 7-14 days 2 Control of infectious synovitis caused by Mycoplasma synoviae susceptible to oxytetracycline 200 g/ton Feed continuously for 7-14 days 4 Control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis) susceptible to oxytetracycline 25 mg/lb of body weight daily Feed continuously for 7-14 days 16.7¹ WARNING: At 200 g/ton use level or higher, withdraw 5 days before slaughter. Zero-day withdrawal period for lower use levels. Do not administer to turkeys producing eggs for human consumption. SWINE Treatment of bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis susceptible to oxytetracycline and treatment of bacterial pneumonia caused by Pasteurellamultocida susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for 7-14 days 102 For breeding swine for control and treatment of Leptospirosis (reducing the incidence of abortion and shedding of leptospirae) caused by Leptospira pomona susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for not more than 14 days 102 CALVES, BEEF CATTLE, AND NONLACTATING DAIRY CATTLE For growing cattle (over 400 lb) for the reduction of the incidence of liver abscesses 75 mg/head/day Feed continuously 1.53 Prevention and treatment of the early stages of shipping fever complex. (Feed 3-5 days before and after arrival in feedlots.) 0.5-2.0 g/head/day 10-403 Treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for 7-14 days 1004 SHEEP Treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for 7-14 days 245 WARNING: 5-day withdrawal before slaughter. 1If bird weighs 10 lb, consuming 0.6 lb of complete feed per day 2Pig consuming 4 lb of complete feed per 100 lb body weight per day 3Include in feed supplement based on consumption of 2 lb of supplement per head per day 4If animal weighs 500 lb, consuming 2 lb of supplement per head per day 5If lamb weighs 60 lb, consuming 1 lb of supplement per head per day RESTRICTED DRUG (CALIFORNIA) – USE ONLY AS DIRECTED NOT FOR HUMAN USE

ORAL

Terramycin® 50 (oxytetracycline) TYPE A MEDICATED ARTICLE

Mixing and Use Directions Thoroughly mix the amount of this Type A medicated article according to the directions below with at least an equal amount by weight of feed formula ingredients prior to blending into a complete feed. Indications for Use Oxytetracycline Amount lb of Terramycin 200 Granular /ton CHICKENS Control of infectious synovitis caused by Mycoplasma synoviae; control of fowl cholera caused by Pasteurella multocida susceptible to oxytetracycline 100-200 g/ton Feed continuously for 7-14 days 0.5-1 Control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and Escherichia coli susceptible to oxytetracycline 400 g/ton Feed continuously for 7-14 days 2 Reduction of mortality due to air sacculitis (air sac infection) caused by Escherichia coli susceptible to oxytetracycline 500 g/ton Feed continuously for 5 days 2.5 WARNING: At 500 g/ton level, withdraw 24 hours before slaughter. Zero-day withdrawal period for lower use levels. Do not use in low-calcium feed containing less than 0.55 dietary calcium. Use in such may result in violative residues. Do not administer to chickens producing eggs for human consumption. TURKEYS Control of hexamitiasis caused by Hexamita meleagridis susceptible to oxytetracycline 100 g/ton Feed continuously for 7-14 days 0.5 Control of infectious synovitis caused by Mycoplasma synoviae susceptible to oxytetracycline 200 g/ton Feed continuously for 7-14 days 1 Control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis) susceptible to oxytetracycline 25 mg/lb of body weight daily Feed continuously for 7-14 days 4.151 WARNING: At 200 g/ton use level or higher, withdraw 5 days before slaughter. Zero-day withdrawal period for lower use levels. Do not administer to turkeys producing eggs for human consumption. SWINE Treatment of bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis susceptible to oxytetracycline and treatment of bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for 7-14 days 2.52 For breeding swine for control and treatment of Leptospirosis (reducing the incidence of abortion and shedding of leptospirae) caused by Leptospira pomona susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for not more than 14 days 2.52 CALVES, BEEF CATTLE, AND NONLACTATING DAIRY CATTLE For growing cattle (over 400 lb) for reduction of liver condemnation due to liver abscesses 75 mg/head/day Feed continuously 0.3753 Prevention and treatment of the early stages of shipping fever complex. (Feed 3-5 days before and after arrival in feedlots.) 0.5-2.0 g/head/day 2.5-103 Treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for 7-14 days 254 SHEEP Treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia caused by Pasteurella multocida susceptible to oxytetracycline 10 mg/lb of body weight daily Feed continuously for 7-14 days 65 WARNING: 5-day withdrawal before slaughter. 1If bird weighs 10 lb, consuming 0.6 lb of complete feed per day 2Pig consuming 4 lb of complete feed per 100 lb body weight per day 3Include in feed supplement based on consumption of 2 lb of supplement per head per day 4If animal weighs 500 lb, consuming 2 lb of supplement per head per day 5If lamb weighs 60 lb, consuming 1 lb of supplement per head per day

ORAL

Terramycin® 200 Granular (oxytetracycline) TYPE A MEDICATED ARTICLE

SPECIES INDICATIONS FOR USE FEEDING DIRECTIONS SALMONIDS For control of ulcer disease caused by Hemophilus piscium, furunculosis caused by Aeromonas salmonicida, bacterial hemorrhagic septicemia caused by Aeromonas liquefaciens and pseudomonas disease. Administer medicated feed to provide a dosage of 2.5 - 3.75 g of oxytetracycline per 100 lb of fish daily for 10 days (see finfish mixing directions below). If mortality is not reduced by the fifth day of treatment, the diagnosis should be reexamined. Warning: Do not liberate or slaughter salmonids for food during treatment or for 21 days following last feeding of medicated feed. PACIFIC SALMON WEIGHING UP TO 30 GRAMS For marking of skeletal tissue. Administer medicated feed as the sole ration to provide a dosage of 11.35 g of oxytetracycline per 100 lb of fish (250 mg per kg of fish) daily for 4 consecutive days. Warning: Do not liberate for at least 7 days following last feeding of medicated feed. FRESHWATER-REARED SALMONIDS For the control of mortality in freshwater-reared salmonids due to coldwater disease associated with Flavobacterium psychrophilum. Administer medicated feed to provide a dosage of 3.75 g of oxytetracycline per 100 lb of fish daily for 10 days (see finfish mixing directions below). Warning: Do not liberate or slaughter freshwater-reared salmonids for food during treatment or for 21 days following last feeding of medicated feed. FRESHWATER-REARED SALMONIDS WEIGHING UP TO 55 GRAMS For marking of skeletal tissue. Administer medicated feed to provide a dosage of 3.75 g of oxytetracycline per 100 lb of fish daily for 10 days (see finfish mixing directions below). Warning: Immediate release is permitted following last feeding of medicated feed. FRESHWATER-REARED Oncorhynchus mykiss For the control of mortality in freshwater-reared Oncorhynchus mykiss due to columnaris disease associated with Flavobacterium columnare. Administer medicated feed to provide a dosage of 3.75 g of oxytetracycline per 100 lb of fish daily for 10 days (see finfish mixing directions below). Warning: Do not liberate or slaughter Oncorhynchus mykissfor food during treatment or for 21 days following last feeding of medicated feed. CATFISH For control of bacterial hemorrhagic septicemia caused by Aeromonas liquefaciens and pseudomonas disease. Administer medicated feed to provide a dosage of 2.5 - 3.75 g of oxytetracycline per 100 lb of fish daily for 10 days (see finfish mixing directions below). If mortality is not reduced by the fifth day of treatment, the diagnosis should be reexamined. Warning: Do not liberate or slaughter catfish for food during treatment or for 21 days following last feeding of medicated feed. Do not use when water temperature is below 62°F (16.7°C). LOBSTER For control of gaffkemia caused by Aerococcus viridans. Administer 1 g/lb of medicated feed as sole ration for 5 consecutive days (see lobster mixing directions below). Warning: Withdraw medicated feed 30 days before harvesting lobsters.

ORAL

Terramycin® 200 for Fish TYPE A MEDICATED ARTICLE

Cattle: BIO-MYCIN 200 is to be administered by intramuscular, subcutaneous, or intravenous injection. Intramuscular administration is not recommended according to Beef Quality Assurance Guidelines. A single dosage of 9 milligrams of BIO-MYCIN 200 per pound of body weight administered intramuscularly or subcutaneously is recommended in the treatment of the following conditions: 1) bacterial pneumonia caused by Pasteurella spp. (shipping fever) in calves and yearlings, where retreatment is impractical due to husbandry conditions, such as cattle on range, or where their repeated restraint is inadvisable; 2) infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis. Discontinue treatment at least 28 days prior to slaughter of cattle. Milk taken from animals during treatment and for 96 hours after the last treatment must not be used for food. BIO-MYCIN 200 can also be administered by intravenous, subcutaneous, or intramuscular injection at a level of 3 to 5 milligrams of oxytetracycline per pound of body weight per day. In the treatment of severe foot-rot and advanced cases of other indicated diseases, a dosage level of 5 milligrams per pound of body weight per day is recommended. Treatment should be continued 24 to 48 hours following remission of disease signs; however, not to exceed a total of four consecutive days. Consult your veterinarian if improvement is not noted within 24 to 48 hours of the beginning of treatment. Swine: In swine a single dosage of 9 milligrams of BIO-MYCIN 200 per pound of body weight administered intramuscularly is recommended in the treatment of bacterial pneumonia caused by Pasteurella multocida in swine, where retreatment is impractical due to husbandry conditions or where repeated restraint is inadvisable. Discontinue treatment 28 days prior to slaughter of swine. BIO-MYCIN 200 can also be administered by intramuscular injection at a level of 3 to 5 milligrams of oxytetracycline per pound of body weight per day. Treatment should be continued 24 to 48 hours following remission of disease signs; however, not to exceed a total of four consecutive days. Consult your veterinarian if improvement is not noted within 24 to 48 hours of the beginning of treatment. For sows, administer once intramuscularly 3 milligrams of oxytetracycline per pound of body weight approximately 8 hours before farrowing or immediately after completion of farrowing. For swine weighing 25 lb of body weight and under, BIO-MYCIN 200 should be administered undiluted for treatment at 9 mg/lb but should be administered diluted for treatment at 3 or 5 mg/lb.

INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS

Bio-Mycin® 200 (oxytetracycline injection)

FOR TYPE A MEDICATED ARTICLE QUANTITIES LESS THAN ONE POUND. MIX THE PROPER AMOUNT OF TYPE A MEDICATED ARTICLE WITH AT LEAST TEN POUNDS OF FEED INGREDIENTS TO MAKE A PREBLEND. ADD THE PREBLEND TO THE REMAINING FEED INGREDIENTS AND MIX THOROUGHLY. INDICATIONS FOR USE Use Level of Terramycin LB OF Terramycin 100MR/TON CALVES - MILK REPLACERS Treatment of bacterial enteritis caused by Escherichia coli susceptible to oxytetracycline 10 mg/lb body weight daily Feed continuously for 7-14 days 201 1Calf weighing 100 lbs. consuming 1 lb. of dry milk replacer mixed with one gallon water. HONEY BEES Control of American Foulbrood caused by Paenibacillus larvae, and European Foulbrood caused by Melissococcus plutonius susceptible to oxytetracycline 200 mg/oz (Dusting) 200 mg/5 lb (Syrup) 800 mg/patty (Extender Patty) See Mixing, Preparation, and Feeding Directions below Mixing and Use Directions for Honey Bees To manufacture a Type C medicated feed containing 200 mg of oxytetracycline hydrochloride activity per oz (dusting Type C Medicated feed) mix 7 lb of Terramycin 100MR with 211 lb of powdered sugar (for a total of 218 lb). The resulting Type C medicated is fed as-is for dusting or may be used to prepare syrup and extender patty feeds. Feeding Directions for Dusting: Dusting: Apply 1 oz (200 mg oxytetracycline) of dusting Type C medicated feed per colony every 4 to 5 days for a total of 3 applications. Apply the dust on the outer parts or ends of the frames. Caution: Dusting of uncapped brood cells has been reported to cause death of larval honey bees. Do not dust uncapped brood cells. Preparation and Feeding Directions for Syrup: Preparation: First dissolve 1 oz (200 mg oxytetracycline) of the dusting Type C medicated feed in a small quantity of water, then mix into 5 lb of 1:1 sugar syrup (equal parts sugar and water. w/w). Feeding: Feed 5 lb of syrup (200 mg oxytetracycline) per colony every 4 to 5 days for a total of 3 applications. Bulk feed the syrup using feeder pails, or division board feeders, or by filling the combs. Prepare fresh syrup for each application. Preparation and Feeding Directions for Extender Patty: Preparation: Make one patty by mixing 4 oz (800 mg oxytetracycline) of the dusting Type C medicated with 5.8 oz. (165 g) of vegetable shortening and 11.6 oz (330 g) of sugar. Feeding: Place one patty per colony on the top bars of the brood nest frames in a single application.

ORAL

Terramycin® 100MR (oxytetracycline) TYPE A MEDICATED ARTICLE

DOSAGE: Cattle: AGRIMYCIN® 200 is to be administered by subcutaneous (SC, under the skin) or intravenous injection according to Beef Quality Assurance Guidelines. A single dosage of 9 mg of AGRIMYCIN® 200 per lb of body weight administered subcutaneously is recommended in the treatment of the following conditions: 1) bacterial pneumonia caused by Pasteurella spp. (shipping fever) in calves and yearlings, where retreatment is impractical due to husbandry conditions, such as cattle on range, or where their repeated restraint is inadvisable; 2) infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis. AGRIMYCIN® 200 can also be administered by subcutaneous or intravenous injection at a level of 3-5 mg of oxytetracycline per lb of body weight per day. In the treatment of severe foot rot and advanced cases of other indicated diseases, a dosage level of 5 mg/lb of body weight per day is recommended. Treatment should be continued 24-48 hours following remission of disease signs; however, not to exceed a total of 4 consecutive days. Consult your veterinarian if improvement is not noted within 24-48 hours of the beginning of treatment. Swine: A single dosage of 9 mg of AGRIMYCIN® 200 per lb of body weight administered intramuscularly in the neck region is recommended in the treatment of bacterial pneumonia caused by Pasteurella multocida in swine, where retreatment is impractical due to husbandry conditions or where repeated restraint is inadvisable. AGRIMYCIN® 200 can also be administered by intramuscular injection at a level of 3-5 mg of oxytetracycline per lb of body weight per day. Treatment should be continued 24-48 hours following remission of disease signs; however, not to exceed a total of 4 consecutive days. Consult your veterinarian if improvement is not noted within 24-48 hours of the beginning of treatment. For sows, administer once intramuscularly in the neck region 3 mg of oxytetracycline per lb of body weight approximately 8 hours before farrowing or immediately after completion of farrowing. For swine weighing 25 lb of body weight and under, AGRIMYCIN® 200 should be administered undiluted for treatment at 9 mg/lb but should be administered diluted for treatment at 3 or 5 mg/lb. * To prepare dilution, add 1 part AGRIMYCIN® 200 to 3, 5 or 7 parts of sterile water, or 5% dextrose solution as indicated; the diluted product should be used immediately.

SUBCUTANEOUS, INTRAMUSCULAR, INTRAVENOUS

FDA application 200-128

Note that feeding rates may vary depending on the size and health of the fish. Feeding rates should be chosen to ensure that all fish in the rearing unit are adequately medicated. Use the table below to calculate the amount of Terramycin 200 for Fish to use at your feeding rate. Feeding Rate* To achieve a dose rate of 2.5 – 3.75 g/100 pounds of fish pounds/100 pounds (%) Terramycin concentration Type C Medicated Feed Terramycin 200 for Fish per ton of feed Total biomass that one ton of medicated feed will treat** 1 2 3 4 5 6 7 8 9 10 15 (g/ton) 5,000 – 7,500 2,500 – 3,750 1,667 – 2,500 1,250 – 1,875 1,000 – 1,500 833 – 1,250 714 – 1071 625 – 938 556 – 833 500 – 750 333 – 500 (pounds) 25.00 – 37.50 12.50 – 18.75 8.33 – 12.50 6.25 – 9.38 5.00 – 7.50 4.17 – 6.25 3.57 – 5.36 3.13 – 4.69 2.78 – 4.17 2.50 – 3.75 1.67 – 2.50 (pounds) 200,000 100,000 66,667 50,000 40,000 33,333 28,571 25,000 22,222 20,000 13,333 * To calculate g Terramycin per ton finished feed at other feeding rates: (desired dose rate/feeding rate) x 2000 To calculate Terramycin 200 for Fish per ton at other feeding rates: g Terramycin per ton finished feed/200 Example: at a feeding rate of 2.5% (2.5 pounds per 100 pounds), with a desired dose of 3.75 g/100 pounds: 3.75 g per 100 lb/2.5 lb per 100 lb = 1.5 g per lb x 2000 lb = 3000 g Terramycin/ton 3000 g Terramycin per ton/200 g Terramycin per lb of Terramycin 200 for Fish = 15 pounds Terramycin per ton of feed ** To calculate total required medicated feed for the 10 day treatment period, multiply total estimated rearing unit biomass by 10 and divide by the pounds of medicated feed needed at your feeding rate Example: at a feeding rate of 2% in a unit containing 5,000 pounds of fish biomass: 5,000 lb x 10 = 50,000 lb/100,000 lb per ton = 0.5 tons

ORAL

Terramycin® 200 for Fish TYPE A MEDICATED ARTICLE

Beef cattle, non-lactating dairy cattle, calves, including pre-ruminating (veal) calves: A single intramuscular or subcutaneous dosage of 13.6 mg of oxytetracycline per pound of bodyweight, Noromycin 300 LA is recommended for the control of respiratory disease in cattle at high risk of developing BRD associated with Mannheimia (Pasteurella) haemolytica. At a single intramuscular or subcutaneous dose range of 9 to 13.6 mg of oxytetracycline per pound of bodyweight, Noromycin 300 LA is recommended in the treatment of the following conditions: Bacterial pneumonia caused by Pasteurella spp (shipping fever) in calves and yearlings where retreatment is impractical due to husbandry conditions, such as cattle on range, or where their repeated restraint is inadvisable. Infectious bovine kertaconjunctivitis (pink eye) caused by Moraxella bovis. For other indications Noromycin 300 LA is to be administered intramuscularly, subcutaneously or intravenously at a level of 3 to 5 mg of oxytetracycline per pound of bodyweight per day. In treatment of foot-rot and advanced cases of other indicated diseases, a dosage level of 5 mg per pound of bodyweight per day is recommended. Treatment should be continued 24 to 48 hours following remission of disease signs, however, not to exceed a total of four (4) consecutive days. If improvement is not noted within 24 to 48 hours of the beginning of treatment, diagnosis and therapy should be re-evaluated. Do not administer intramuscularly in the neck of small calves due to lack of sufficient muscle mass. Use extreme care when administering this product by intravenous injection. Perivascular injection or leakage from an intravenous injection may cause severe swelling at the injection site.

INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS

FDA application 141-143

MIXING DIRECTIONS FOR WATER MEDICATION CHICKENS — TURKEYS — SWINE Dosage and indications for use in water proportioners - Add the following amount to 1 gallon of stock solution when proportioner is set to meter at the rate of 1 oz per gallon. C H I C K E N S Disease Treatment Level Pack/Gallon Stock Control of infectious synovitis caused by Mycoplasma synoviae, susceptible to oxytetracycline. 200 - 400 mg ¼ - ½ (70 - 140 g) Control of chronic respiratory disease (CRD) and air sac infections caused by Mycoplasma gallisepticum and Escherichia coli, susceptible to oxytetracycline. 400 - 800 mg ½ - 1 (140 - 280 g) Control of fowl cholera caused by Pasteurella multocida, susceptible to oxytetracycline. 400 - 800 mg ½ - 1 (140 - 280 g) T U R K E Y S Control of hexamitiasis caused by Hexamita meleagridis, susceptible to oxytetracycline. 200 - 400 mg ¼ - ½ (70 - 140 g) Control of infectious synovitis caused by Mycoplasma synoviae, susceptible to oxytetracycline. 400 mg ½ (140 g) GROWING TURKEYS — Control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis), susceptible to oxytetracycline. 25 mg/lb body weight Varies with age & water consumption S W I N E FOR THE CONTROL AND TREATMENT OF THE FOLLOWING DISEASES IN SWINE – Bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis, susceptible to oxytetracycline. Bacterial pneumonia caused by Pasteurella multocida, susceptible to oxytetracycline. FOR BREEDING SWINE: Leptospirosis (reducing the incidence of abortions and shedding of leptospira) caused by Leptospira pomona, susceptible to oxytetracycline. 10 mg/lb body weight Varies with age & water consumption

ORAL

FDA application 130-435

MIXING DIRECTIONS FOR WATER MEDICATION CHICKENS — TURKEYS — SWINE Dosage and indications for use in water proportioners - Add 1 pack to the following amount of water to make a stock solution for use in a proportioner set to meter at the rate of one ounce per gallon. C H I C K E N S Disease Treatment Level Gallons Stock/Pack Control of infectious synovitis caused by Mycoplasma synoviae, susceptible to oxytetracycline. 200 - 400 mg 25.3 - 12.6 Control of chronic respiratory disease (CRD) and air sac infections caused by Mycoplasma gallisepticum and Escherichia coli, susceptible to oxytetracycline. 400 - 800 mg 12.6 - 6.3 Control of fowl cholera caused by Pasteurella multocida, susceptible to oxytetracycline. 400 - 800 mg 12.6 - 6.3 T U R K E Y S Control of hexamitiasis caused by Hexamita meleagridis, susceptible to oxytetracycline. 200 - 400 mg 25.3 - 12.6 Control of infectious synovitis caused by Mycoplasma synoviae, susceptible to oxytetracycline. 400 mg 12.6 GROWING TURKEYS — Control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis), susceptible to oxytetracycline. 25 mg/lb body weight Varies with age & water consumption S W I N E FOR THE CONTROL AND TREATMENT OF THE FOLLOWING DISEASES IN SWINE – Bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis, susceptible to oxytetracycline. Bacterial pneumonia caused by Pasteurella multocida, susceptible to oxytetracycline. FOR BREEDING SWINE: Leptospirosis (reducing the incidence of abortions and shedding of leptospira) caused by Leptospira pomona, susceptible to oxytetracycline. 10 mg/lb body weight Varies with age & water consumption

ORAL

FDA application 130-435

Mix Neo-Terramycin 100/100D with nonmedicated milk replacer to provide the following drug concentrations: Indications for Use Oxytetracycline and Neomycin Amount lb. of Neo-Terramycin 100/100D per ton1 CALVES (milk replacer) For calves (up to 250 lb) for treatment of bacterial enteritis caused by E. coli susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin 10 mg/lb of body weight daily Feed continuously for 7-14 days Treatment should continue 24 to 48 hours beyond remission of disease symptoms. 202 CALVES, BEEF CATTLE, AND NONLACTATING DAIRY CATTLE Treatment of bacterial enteritis caused by E. coli and bacterial pneumonia (shipping fever complex) caused by Pasteurella multocida susceptible to oxytetracycline; treatment and control of colibacillosis (bacterial enteritis) caused by E. coli susceptible to neomycin 10 mg/lb of body weight daily Feed continuously for 7-14 days Treatment should continue 24 to 48 hours beyond remission of disease symptoms. 202 WARNING: A withdrawal period has not been established in preruminating calves; do not use in calves to be processed for veal. At the 10 mg/lb level, withdraw 5 days before slaughter. Use of more than one product containing neomycin or failure to follow withdrawal times may result in illegal drug residues. A milk discard time has not been established for use in lactating dairy cattle. Do not use in female dairy cattle 20 months of age or older. 1Mixing directions are for example only and are based on mixing 1 lb of dry milk replacer with 1 gallon of water. 2If calf weighs 100 lb, consuming 1 gallon of milk replacer per day.

ORAL

Neo-Terramycin® 100/100D (neomycin-oxytetracycline) TYPE A MEDICATED ARTICLE

MIXING DIRECTIONS FOR WATER MEDICATION CHICKENS — TURKEYS — SWINE Dosage and indications for use in water proportioners - Add 1 pack to the following amount of water to make a stock solution for use in a proportioner set to meter at the rate of one ounce per gallon. C H I C K E N S Disease Treatment Level Gallons Stock/Pack Control of infectious synovitis caused by Mycoplasma synoviae, susceptible to oxytetracycline. 200 - 400 mg 20 - 10 Control of chronic respiratory disease (CRD) and air sac infections caused by Mycoplasma gallisepticum and Escherichia coli, susceptible to oxytetracycline. 400 - 800 mg 10 - 5 Control of fowl cholera caused by Pasteurella multocida, susceptible to oxytetracycline. 400 - 800 mg 10 - 5 T U R K E Y S Control of hexamitiasis caused by Hexamita meleagridis, susceptible to oxytetracycline. 200 - 400 mg 20 - 10 Control of infectious synovitis caused by Mycoplasma synoviae, susceptible to oxytetracycline. 400 mg 10 GROWING TURKEYS — Control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis), susceptible to oxytetracycline. 25 mg/lb body weight Varies with age & water consumption S W I N E FOR THE CONTROL AND TREATMENT OF THE FOLLOWING DISEASES IN SWINE – Bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis, susceptible to oxytetracycline. Bacterial pneumonia caused by Pasteurella multocida, susceptible to oxytetracycline. FOR BREEDING SWINE: Leptospirosis (reducing the incidence of abortions and shedding of leptospira) caused by Leptospira pomona, susceptible to oxytetracycline. 10 mg/lb body weight Varies with age &water consumption

ORAL

FDA application 130-435

1.Approximate location of vein. The jugular vein runs in the jugular groove on each side of the neck from the angle of the jaw to just above the brisket and slightly above and to the side of the windpipe. (See Fig. I). 2.Restraint. A stanchion or chute is ideal for restraining the animal. With a halter, rope, or cattle leader (nose tongs), pull the animal’s head around the side of the stanchion, cattle chute, or post in such a manner to form a bow in the neck (See Fig. II), then snub the head securely to prevent movement. By forming the bow in the neck, the outside curvature of the bow tends to expose the jugular vein and make it easily accessible. Caution: Avoid restraining the animal with a tight rope or halter around the throat or upper neck which might impede blood flow. Animals that are down present no problem as far as restraint is concerned. 3.Clip hair in area where injection is to be made (over the vein in the upper third of the neck). Clean and disinfect the skin with alcohol or other suitable antiseptic. Fig. I Fig. I Figure II

INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS

Bio-Mycin® 200 (oxytetracycline injection)

Subcutaneous injections in beef cattle and dairy cattle should be made by directing the needle of suitable gauge and length through the loose folds of the neck skin in front of the shoulder. Care should be taken to ensure that the tip of the needle has penetrated the skin but is not lodged in muscle. Before injecting the solution, pull back gently on the plunger. If blood appears in the syringe, a blood vessel has been entered; withdraw the needle and select a different site. The solution should be injected slowly into the area between the skin and muscles. No more than 10 mL should be injected subcutaneously at any one site in adult beef cattle and dairy cattle; rotate injection sites for each succeeding treatment. The volume administered per injection site should be reduced according to age and body size so that 1 to 2 mL per site is injected in small calves.

INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS

Bio-Mycin® 200 (oxytetracycline injection)

Dosage: Cattle: A single dosage of 9 mg of oxytetracycline per lb of body weight (4.5 mL/100 lb) administered subcutaneously is recommended in the treatment of the following conditions: 1) bacterial pneumonia caused by Pasteurella spp. (shipping fever) in calves and yearlings, where retreatment is impractical due to husbandry conditions, such as cattle on range, or where repeated restraint is inadvisable; 2) infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis. Swine: A single dosage of 9 mg of oxytetracycline per lb of body weight (4.5 mL/100 lb) administered intramuscularly is recommended in the treatment of bacterial pneumonia caused by Pasteurella multocida in swine, where retreatment is impractical due to husbandry conditions or where repeated restraint is inadvisable. Refer to Package Onsert for Complete Directions.

SUBCUTANEOUS, INTRAMUSCULAR, INTRAVENOUS

FDA application 200-128

Intramuscular injections should be made by directing the needle of suitable gauge and length into the fleshy part of a thick muscle in the neck region; avoid blood vessels and major nerves. Before injecting the solution, pull back gently on the plunger. If blood appears in the syringe, a blood vessel has been entered; withdraw the needle and select a different site. In cattle, intramuscular administration is not recommended according to Beef Quality Assurance Guidelines. No more than 10 mL should be injected intramuscularly at any one site in adult beef cattle and dairy cattle, and not more than 5 mL per site in adult swine; rotate injection sites for each succeeding treatment. The volume administered per injection site should be reduced according to age and body size so that 1 to 2 mL per site is injected in small calves.

INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS

Bio-Mycin® 200 (oxytetracycline injection)

Liquamycin LA-200 is intended for use in the treatment of disease due to oxytetracycline-susceptible organisms in beef cattle; dairy cattle; calves, including preruminating (veal) calves; and swine. A thoroughly cleaned, sterile needle and syringe should be used for each injection (needles and syringes may be sterilized by boiling in water for 15 minutes). In cold weather, Liquamycin LA-200 should be warmed to room temperature before administration to animals. Before withdrawing the solution from the bottle, disinfect the rubber cap on the bottle with suitable disinfectant, such as 70% alcohol. The injection site should be similarly cleaned with the disinfectant. Needles of 16–18 gauge and 1–1½ inches long are adequate for intramuscular and subcutaneous injections. Needles 2–3 inches are recommended for intravenous use.

INTRAVENOUS, SUBCUTANEOUS

Liquamycin® LA-200®

For control of bacterial enteritis and bacterial pneumonia orally administer 1 tablet per 100 lb of body weight every 12 hours (5 mg/ lb of body weight daily in divided doses) for up to 4 consecutive days. For treatment of bacterial enteritis and bacterial pneumonia orally administer 2 tablets per 100 lb of body weight every 12 hours (10 mg/lb of body weight daily in divided doses) for up to 4 consecutive days. Dosage should continue until the animal returns to normal and for 24–48 hours after symptoms have subsided. Treatment should not exceed 4 consecutive days.

ORAL

Terramycin® Scours Tablets

BIO-MYCIN 200 (oxytetracycline injection) may be administered intravenously to beef cattle and dairy cattle. As with all highly concentrated materials, BIO-MYCIN 200 should be administered slowly by the intravenous route.

INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS

Bio-Mycin® 200 (oxytetracycline injection)

Terramycin (Oxytetracycline Hydrochloride and Polymyxin B Sulfate Ophthalmic Ointment) should be administered topically to the eye 2–4 times daily.

TOPICAL

Terramycin®